Sci Rep 2017 10 19;7(1):13562. Epub 2017 Oct 19.
Institute for Lasers, Photonics, and Biophotonics and Department of Chemistry, University at Buffalo, State University of New York, Buffalo, New York, 14260, United States.
An organic-inorganic hybrid core-shell nanostructure, based on mesoporous silica coated upconversion core-shell nanoparticles (NaGdF:Yb,[email protected]:[email protected] abbreviated here as [email protected]) that stably incorporates dopamine (Dopa) in the silica layer was introduced as a theranostic nanoplatform for optical imaging guided photothermal therapy (PTT) using NIR excitation. Silica-attaching polyethylenimine make the Dopa transforms into an active form (transferred Dopa) that strongly absorbs light under single 980 nm irradiation. We show that the activated [email protected] nanoplatform is able to produce a pronounced photothermal effect, that elevates water temperature from room temperature to 41. Read More