2,942 results match your criteria absent uptake

A Striking Case of Perfusion-Metabolism "Flip-Flop" in a Patient With Left Anterior Descending Artery Total Occlusion.

Clin Nucl Med 2021 Jul 26. Epub 2021 Jul 26.

From the Department of Radiology and Nuclear Medicine, School of Medicine, University of Jordan Department of Nuclear Medicine, Royal Medical Services, Amman, Jordan.

Abstract: A 57-year-old man diagnosed with left anterior descending artery chronic total occlusion underwent rest gated 99mTc-MIBI scan showing moderately to markedly decreased perfusion with abnormal wall motion in the apex, anterior, anteroseptal, and apical anterolateral walls. 18F-FDG PET showed a "flip-flop" phenomenon with markedly increased FDG uptake in the hypoperfused regions and absent/markedly decreased uptake in the normally perfused, normokinetic myocardium, presumably due to the predominant use of free fatty acids under normoxic conditions. After coronary artery bypass grafting, left ventricular motion normalized except for surgery-related paradoxical septal motion and the left ventricular ejection fraction improved from 52% to 68%. Read More

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Novel Homozygous Truncating Variant Widens the Spectrum of Early-Onset Multisystemic SYNE1 Ataxia.

Cerebellum 2021 Jul 28. Epub 2021 Jul 28.

Department of Neurology, University of Copenhagen, Rigshospitalet, Inge Lehmanns Vej 8, 2100, Copenhagen, Denmark.

Pathogenic variants in the SYNE1 gene are associated with a phenotypic spectrum spanning from late-onset, slowly progressive, relatively pure ataxia to early-onset, fast progressive multisystemic disease. Since its first description in 2007 as an adult-onset ataxia in French Canadian families, subsequent identification of patients worldwide has widened the clinical spectrum and increased the number of identified pathogenic variants. We report a 20-year-old Faroese female with early-onset progressive gait problems, weakness, dysphagia, slurred speech, orthostatic dizziness, and urge incontinence. Read More

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A novel synthesis of a chlorophyll b-gold nanoconjugate used for enhancing photodynamic therapy: In vitro study.

Photodiagnosis Photodyn Ther 2021 Jul 17;35:102444. Epub 2021 Jul 17.

National Institute of Laser Enhanced Science, Cairo University, Egypt. Electronic address:

Chlorophyll, the essential green pigment in plants, is considered a promising natural photosensitizer (PS) for photodynamic therapy (PDT). However, it suffers from lower stability in the physiological conditions that depress its efficacy in the PDT. The combination of nanotechnology and PDT is becoming a promising approach to combat tumors. Read More

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Effect of Diet on Physiological Bowel F-FDG Uptake.

J Nucl Med Technol 2021 Jul 9. Epub 2021 Jul 9.

Tehran University of Medical Sceinces, Iran, Islamic Republic of.

Intestinal F-FDG uptake is variable in whole body PET/CT scan. In cancer patients, in particular those suspected for relapse or metastasis, F-FDG absorption might interfere with scan interpretation. This study was conducted in order to evaluate the effect of the diet on intestinal F-FDG absorption. Read More

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Stable isotope fractionation reveals similar atomic level controls during aerobic and anaerobic microbial Hg transformation pathways.

Appl Environ Microbiol 2021 Jul 7:AEM0067821. Epub 2021 Jul 7.

Biology Department, University of Ottawa, 30 Marie Curie, Ottawa, ON, K1N 6N5, Canada.

Mercury (Hg) is a global pollutant and potent neurotoxin that bioaccumulates in food webs as monomethylmercury (MeHg). The production of MeHg is driven by anaerobic and Hg redox cycling pathways such as Hg reduction, which control the availability of Hg to methylators. Anaerobes play an important role in Hg reduction in methylation hotspots, yet their contributions remain underappreciated due to how challenging these pathways are to study in the absence of dedicated genetic targets and low levels of Hg in anoxic environments. Read More

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Histological changes at the commissure of the lip on approaching from its cutaneous to the mucosa region in males.

Natl J Maxillofac Surg 2021 Jan-Apr;12(1):88-92. Epub 2021 Mar 16.

Department of Anatomy, King George's Medical University, Lucknow, Uttar Pradesh, India.

Introduction: The morphology of the epithelium of the oral lips comprised keratinized external epithelium (anteriorly) and nonkeratinized or sometimes parakeratinized mucous membrane epithelium (posteriorly). Knowledge of morphometry of the lip lining helps in deciding the best site for choosing graft for its better uptake during several dermal grafting procedures following trauma or tumor excision following craniofacial cancers or cosmetic procedures.

Materials And Methods: Ten human male cadavers were procured at the Department of Anatomy King George's Medical University, Lucknow, Uttar Pradesh. Read More

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The value of [68Ga]Ga-DOTA-TATE PET/CT in diagnosis and management of suspected pituitary tumors.

Eur J Hybrid Imaging 2021 May 24;5(1):10. Epub 2021 May 24.

Institute of Nuclear Medicine, University College London Hospital, London, UK.

Background: Gallium 68-tetraazacyclododecane-tetraacetic acid-octreotate ([68Ga]Ga-DOTA-TATE) is a selective somatostatin analogue ligand, which shows increased affinity for somatostatin receptor subtype (SSTR) 2 and has been used routinely for imaging neuroendocrine tumors with PET/CT. We investigated the utility of [68Ga]Ga-DOTA-TATE positron emission tomography/computed tomography (PET/CT) in patients with suspected pituitary pathology. We reviewed imaging for twenty consecutive patients (8 men, 12 women, mean age of 48. Read More

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SARS-CoV-2-Related Subacute Thyroiditis, Myocarditis, and Hepatitis After Full Resolution of COVID-19 Serum Markers.

Am J Case Rep 2021 Jun 17;22:e932321. Epub 2021 Jun 17.

Department of Biochemistry and Medicine, La Salle University School of Medicine, Mexico City, Mexico.

BACKGROUND Subacute thyroiditis, myocarditis, and hepatitis are inflammatory disorders that may develop after viral infections, including SARS-CoV-2. These entities may appear after resolution of the respiratory syndrome. CASE REPORT A previously healthy 64-year-old male patient came to the hospital reporting severe chest pain. Read More

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Exocrine pancreas proteases regulate β-cell proliferation in zebrafish ciliopathy models and in murine systems.

Biol Open 2021 Jun 14;10(6). Epub 2021 Jun 14.

Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.

Pancreatic β-cells are a critical cell type in the pathology of diabetes. Models of genetic syndromes featuring diabetes can provide novel mechanistic insights into regulation of β-cells in the context of disease. We previously examined β-cell mass in models of two ciliopathies, Alström Syndrome (AS) and Bardet-Biedl Syndrome (BBS), which are similar in the presence of metabolic phenotypes, including obesity, but exhibit strikingly different rates of diabetes. Read More

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Escherichia coli Dcu C-dicarboxylate transporters dependent proton and potassium fluxes and FF-ATPase activity during glucose fermentation at pH 7.5.

Bioelectrochemistry 2021 Jun 4;141:107867. Epub 2021 Jun 4.

Department of Biochemistry, Microbiology and Biotechnology, Faculty of Biology, Yerevan State University, 1 A. Manoogian str., 0025 Yerevan, Armenia; Scientific-Research Institute of Biology, Yerevan State University, 1 A. Manoogian str., 0025 Yerevan, Armenia; Microbial Biotechnologies and Biofuel Innovation Center, Yerevan State University, 1 A. Manoogian str., 0025 Yerevan, Armenia. Electronic address:

During fermentation in Escherichia coli succinate is transported via Dcu transporters, encoded dcuA, dcuB, dcuC and dcuD although the role of DcuD protein has not been elucidated yet. It has been shown contribution of Dcu transporters in the N,N'-dicyclohexylcarbodiimide (DCCD) sensitive proton and potassium transport through the cytoplasmic membrane and membrane-associated ATPase activity. Total H efflux was decreased ~ 40% while K uptake was absent in dcuD mutant. Read More

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Photoinduced Electron-Transfer (PIET) Strategy for Selective Adsorption of CO over C H in a MOF.

Angew Chem Int Ed Engl 2021 Jun 10. Epub 2021 Jun 10.

State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 155 Yangqiao Road West, Fuzhou, Fujian, 350002, P. R. China.

Similarities in sizes, shapes, and physical properties between carbon dioxide (CO ) and acetylene (C H ) make it a great challenge to separate the major impurity CO from products in C H production. The use of porous materials is an appealing path to replace current very costly and energy-consuming technologies, such as solvent extraction and cryogenic distillation; however, high CO /C H uptake ratio with minor adsorption of C H at standard pressure was only unexpectedly observed in scarce examples in recent years although the related research started early at 1950s, and general design strategies to realize this aim are still absent. This work has successfully developed an efficient PIET strategy and obtained the second highest CO /C H adsorption ratio for porous materials in a proof-of-concept MOF with a photochromism-active bipyridinium zwitterion. Read More

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Using a household-structured branching process to analyse contact tracing in the SARS-CoV-2 pandemic.

Philos Trans R Soc Lond B Biol Sci 2021 07 31;376(1829):20200267. Epub 2021 May 31.

Department of Mathematics, University of Manchester, Manchester M13 9PY, UK.

We explore strategies of contact tracing, case isolation and quarantine of exposed contacts to control the SARS-CoV-2 epidemic using a branching process model with household structure. This structure reflects higher transmission risks among household members than among non-household members. We explore strategic implementation choices that make use of household structure, and investigate strategies including two-step tracing, backwards tracing, smartphone tracing and tracing upon symptom report rather than test results. Read More

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Infants Diagnosed with Athyreosis on Scintigraphy May Have a Gland Present on Ultrasound and Have Transient Congenital Hypothyroidism.

Horm Res Paediatr 2021 27;94(1-2):36-43. Epub 2021 May 27.

Department of Paediatric Endocrinology, Children's Health Ireland at Temple St, Dublin, Ireland.

Scintigraphy using technetium-99m (99mTc) is the gold standard for imaging the thyroid gland in infants with congenital hypothyroidism (CHT) and is the most reliable method of diagnosing an ectopic thyroid gland. One of the limitations of scintigraphy is the possibility that no uptake is detected despite the presence of thyroid tissue, leading to the spurious diagnosis of athyreosis. Thyroid ultrasound is a useful adjunct to detect thyroid tissue in the absence of 99mTc uptake. Read More

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Case Report: Clinical Remission in a Cat With Severe Bilateral Eosinophilic Keratitis Receiving Combined Immunosuppressive Therapy (Triamcinolone Acetonide and Tacrolimus).

Front Vet Sci 2021 30;8:580396. Epub 2021 Apr 30.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, United States.

A 2-year-old domestic shorthair cat was examined for severe keratitis of 10 months duration, non-responsive to 0.1% dexamethasone q8-12h. Patient and owner compliance were poor given ocular discomfort and hiding behavior. Read More

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Necrosis binding of Ac-Lys(IRDye800CW)-Tyr-octreotate: a consequence from cyanine-labeling of small molecules.

EJNMMI Res 2021 May 10;11(1):47. Epub 2021 May 10.

Department of Radiology and Nuclear Medicine/Molecular Genetics, Erasmus Medical Centre, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands.

Background: There is a growing body of nuclear contrast agents that are repurposed for fluorescence-guided surgery. New contrast agents are obtained by substituting the radioactive tag with, or adding a fluorescent cyanine to the molecular structure of antibodies or peptides. This enables intra-operative fluorescent detection of cancerous tissue, leading to more complete tumor resection. Read More

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Couples' decision-making on post-partum family planning and antenatal counselling in Uganda: A qualitative study.

PLoS One 2021 5;16(5):e0251190. Epub 2021 May 5.

Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.

Background: Although health workers have been trained to provide post-partum family planning (PPFP), uptake remains low in Uganda. An important reason is that women want the agreement of their partner, who is often absent at the time of delivery. In order to address this, we aimed to understand the views of couples and explore barriers and facilitators to implementation of antenatal couples' counselling on PPFP in Uganda. Read More

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Macrophage Proteome Analysis at Different Stages of Subspecies Infection Reveals a Mechanism of Pathogen Dissemination.

Proteomes 2021 Apr 30;9(2). Epub 2021 Apr 30.

Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA.

Johne's disease is a chronic and usually fatal enteric infection of ruminants caused by subspecies (MAP) and is responsible for hundreds of millions of dollars in losses for the agricultural industry. Natural infection typically begins with bacterial uptake and translocation through the epithelium of the small intestine, followed by ingestion by tissue macrophages and dissemination via the lymphatic or blood system throughout the body. To gain insights into the host responses and adaptation of MAP within phagocytic cells, we utilized the previously developed cell culture passage model, and mass spectrometric-based quantitative proteomic approach. Read More

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Patient-Specific Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells as a Model to Study Autosomal Recessive Hypercholesterolemia.

Stem Cells Dev 2021 Jul 8;30(14):714-724. Epub 2021 Jun 8.

Stem Cell Institute, Department of Development and Regeneration, University of Leuven (KULeuven), Leuven, Belgium.

Autosomal recessive hypercholesterolemia (ARH) is a rare monogenic disorder caused by pathogenic variants in the low-density lipoprotein receptor (LDLR) adaptor protein 1 () gene, encoding for the LDLRAP1 protein, which impairs internalization of hepatic LDLR. There are variable responses of ARH patients to treatment and the pathophysiological mechanism(s) for this variability remains unclear. This is in part caused by absence of reliable cellular models to evaluate the effect of mutations on the LDLRAP1 protein function and its role in LDLR internalization. Read More

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Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion.

Mol Metab 2021 Apr 28;51:101239. Epub 2021 Apr 28.

Unit of Molecular Metabolism, Lund University Diabetes Center, Lund University, Malmö SE-205 02, Sweden. Electronic address:

Objective: Transport of Ca into pancreatic β cell mitochondria facilitates nutrient-mediated insulin secretion. However, the underlying mechanism is unclear. Recent establishment of the molecular identity of the mitochondrial Ca uniporter (MCU) and associated proteins allows modification of mitochondrial Ca transport in intact cells. Read More

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Enhancing Value and Uptake for Whole-Population Cohorts of Children and Parents: Methods to Integrate Registries into the Generation Victoria Cohort.

Children (Basel) 2021 Apr 7;8(4). Epub 2021 Apr 7.

Murdoch Children's Research Institute, Melbourne 3052, Australia.

Health registries are critical to understanding, benchmarking and improving quality of care for specific diseases and conditions, but face hurdles including funding, bias towards clinical rather than population samples, lack of pre-morbid and outcomes data, and absent cross-registry harmonisation and coordination. Children are particularly under-represented in registry research. This paper lays out novel principles, methods and governance to integrate diverse registries within or alongside a planned children's mega-cohort to rapidly generate translatable evidence. Read More

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False positive technetium-99m pyrophosphate scintigraphy in a patient with cardiac amyloidosis light chain: Case report.

Medicine (Baltimore) 2021 Apr;100(17):e25582

Nuclear Medicine.

Introduction: Patients with cardiac amyloidosis light chain (AL) present with negative Tc-99m pyrophosphate (PYP) scintigraphy (absent or mild heart uptake). On the contrary, patients with cardiac amyloidosis transthyretin (ATTR) present with positive Tc-99m PYP scanning (intensive heart uptake). We present a false positive Tc-99m PYP scintigraphy (grade 2, the heart-to-contralateral ratio is 1. Read More

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Black soldier fly reared on pig manure: Bioconversion efficiencies, nutrients in the residual material, greenhouse gas and ammonia emissions.

Waste Manag 2021 May 16;126:674-683. Epub 2021 Apr 16.

Farming Systems Ecology Group, Wageningen University & Research, PO Box 430, 6700 AK Wageningen, the Netherlands.

There is an increased interest for using insects, such as the black soldier fly, to treat surplus manure and upcycle nutrients into the food system. Understanding the influence that BSFL have on nutrient flows and nutrient losses during manure bioconversion is key for sustainability assessments. Here we quantified and compared nutrient balances, nutrient levels in residual materials and emissions of greenhouse gases and ammonia between manure incubated with black soldier fly larvae (BSFL) and manure without BSFL, during a 9-day experimental period. Read More

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Quantification and exposure assessment of microplastics in Australian indoor house dust.

Environ Pollut 2021 Aug 1;283:117064. Epub 2021 Apr 1.

Department of Earth and Environmental Sciences, Faculty of Science & Engineering, Macquarie University, Sydney, NSW, 2109, Australia.

Limited attention has been given to the presence of MPs in the atmospheric environment, particularly in indoor environments where people spend about 90% of their time. This study quantitatively assesses the prevalence, source and type of MPs in Australian homes with the goal of evaluating human health exposure potential. Thirty-two airborne indoor deposited dust samples were collected in glass Petri dishes from Sydney (Australia) homes, over a one-month period in 2019. Read More

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Absent Exercise-Induced Improvements in Fat Oxidation in Women With Polycystic Ovary Syndrome After High-Intensity Interval Training.

Front Physiol 2021 24;12:649794. Epub 2021 Mar 24.

Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.

Polycystic ovary syndrome (PCOS) and metabolic inflexibility are linked to insulin resistance, and women with PCOS appear to be metabolic inflexible in the rested, insulin-stimulated state. Exercise training is a primary lifestyle intervention in PCOS. Exercise training improves whole-body fat oxidation during submaximal exercise in healthy women, yet little is known about the effect on this outcome in women with PCOS. Read More

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68Ga-PSMA PET/CT Scan on Postoperative Assessment of Sinonasal Glomangiopericytoma.

Clin Nucl Med 2021 Apr 5. Epub 2021 Apr 5.

From the Departments of Otorhinolaryngology & Head and Neck Surgery Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.

Abstract: Prostate-specific membrane antigen (PSMA) is expressed on the endothelial cells of tumor-associated neovasculature of various nonprostatic benign and malignant neoplasms. Positive intense uptake on PET/CT imaging with 68Ga-labeled PSMA is noted in a patient with sinonasal glomangiopericytoma, and the same is noted to be absent following complete surgical excision. 68Ga-PSMA PET/CT may be a useful tool for early recurrence identification, differentiating recurrence from surgical site reparative tissues, and peptide receptor radionuclide therapy of residual lesions. Read More

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Three-Dimensional Tumor Spheroids as a Tool for Reliable Investigation of Combined Gold Nanoparticle and Docetaxel Treatment.

Cancers (Basel) 2021 Mar 23;13(6). Epub 2021 Mar 23.

Department of Physics and Astronomy, University of Victoria, Victoria, BC V8P 5C2, Canada.

Radiotherapy and chemotherapy are the gold standard for treating patients with cancer in the clinic but, despite modern advances, are limited by normal tissue toxicity. The use of nanomaterials, such as gold nanoparticles (GNPs), to improve radiosensitivity and act as drug delivery systems can mitigate toxicity while increasing deposited tumor dose. To expedite a quicker clinical translation, three-dimensional (3D) tumor spheroid models that can better approximate the tumor environment compared to a two-dimensional (2D) monolayer model have been used. Read More

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Novelty-induced hyperactivity and suppressed cocaine induced locomotor activation in mice lacking threonine 53 phosphorylation of dopamine transporter.

Behav Brain Res 2021 Jun 29;408:113267. Epub 2021 Mar 29.

Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, 23298, USA. Electronic address:

Dopamine (DA) transporter (DAT) is dynamically regulated by several protein kinases and the Thr53 phosphorylation of DAT (pT53-DAT) is documented in heterologous cell models and in rat brain. However, the role of endogenous pT53-DAT in living animals has never been addressed. Here we generated and studied the pT53-lacking DAT mouse model (DAT-Ala53) by CRISPR/Cas9 technology. Read More

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SERCA2a stimulation by istaroxime improves intracellular Ca2+ handling and diastolic dysfunction in a model of diabetic cardiomyopathy.

Cardiovasc Res 2021 Apr 1. Epub 2021 Apr 1.

Department of Biotechnology and Biosciences, Università degli Studi di Milano-Bicocca, Milan, Italy.

Aims: Diabetic cardiomyopathy is a multifactorial disease characterized by an early onset of diastolic dysfunction (DD) that precedes the development of systolic impairment. Mechanisms that can restore cardiac relaxation improving intracellular Ca2+ dynamics represent a promising therapeutic approach for cardiovascular diseases associated to DD. Istaroxime has the dual properties to accelerate Ca2+ uptake into sarcoplasmic reticulum (SR) through the SR Ca2+ pump (SERCA2a) stimulation and to inhibit Na+/K+ ATPase (NKA). Read More

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Crop uptake of heavy metals in response to the environment and agronomic practices on land near mine tailings in the Zambian Copperbelt Province.

Environ Geochem Health 2021 Mar 9. Epub 2021 Mar 9.

Inorganic Geochemistry, Centre for Environmental Geochemistry, British Geological Survey, Nottingham, NG12 5GG, UK.

A field experiment was undertaken on farmers' fields adjacent to a large mine tailings dam in the Zambian mining town of Kitwe. Experimental plots were located close to the tailings (≤ 200 m) or further away (300-400 m) within the demarcated land farmed by the same community. This study evaluated the uptake of Cd, Cu, Ni, Pb and Zn by pumpkin leaves and maize grown in soil amended with lime and manure applied at agronomic rates, and the subsequent risk of dietary exposure to the local community, typical of many similar situations across the Zambian Copperbelt. Read More

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Absent Cortical Venous Filling Is Associated with Aggravated Brain Edema in Acute Ischemic Stroke.

AJNR Am J Neuroradiol 2021 06 18;42(6):1023-1029. Epub 2021 Mar 18.

Department of Radiology (H.S., S.H., M.Z., W.H., Z.Z., Y.X., P.F., W.C.), The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

Background And Purpose: Predicting malignant cerebral edema can help identify patients who may benefit from appropriate evidence-based interventions. We investigated whether absent cortical venous filling is associated with more pronounced early brain edema, which leads to malignant cerebral edema.

Materials And Methods: Patients with acute ischemic stroke caused by large-vessel occlusion in the MCA territory who presented between July 2017 and September 2019 to our hospital were included. Read More

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