4,726 results match your criteria absence coronavirus

Chlorine dioxide is a more potent antiviral agent against SARS-CoV-2 than sodium hypochlorite.

J Hosp Infect 2021 Sep 15. Epub 2021 Sep 15.

Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58, Rinkuourai-kita, Izumisano, Osaka 598-8531, Japan; Asian Health Science Research Institute, Osaka Prefecture University, 1-58, Rinkuourai-kita, Izumisano, Osaka 598-8531, Japan; Osaka International Research Center for Infectious Diseases, Osaka Prefecture University, 1-58, Rinkuourai-kita, Izumisano, Osaka 598-8531, Japan. Electronic address:

A new coronavirus (SARS-CoV-2) abruptly emerged in Wuhan, China in 2019 and rapidly spread globally to cause the COVID-19 pandemic. In this study, we examined the anti-SARS-CoV-2 activity of the potent disinfectant Cleverin, the major disinfecting component of which is chlorine dioxide (ClO) and the results were compared with that of sodium hypochlorite in the presence or absence of 0.5% or 1. Read More

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September 2021

Vaccine-induced immune thrombotic thrombocytopenia presenting with normal platelet count.

Res Pract Thromb Haemost 2021 Aug 14;5(6):e12596. Epub 2021 Sep 14.

Division of Hematology Department of Medicine University of Alberta Edmonton AB Canada.

Adenoviral-vector based vaccines for coronavirus disease 2019 (COVID-19) have been linked with a thrombotic syndrome, vaccine-induced thrombotic thrombocytopenia (VITT). A key clinical question is whether VITT can be reliably ruled out by the absence of thrombocytopenia. We report on three patients who presented to our institute with this syndrome. Read More

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Associations Between Movement Behaviors and Emotional Changes in Toddlers and Preschoolers During Early Stages of the COVID-19 Pandemic in Chile.

Front Pediatr 2021 31;9:667362. Epub 2021 Aug 31.

School of Health and Society and Early Start, Faculty of Arts, Social Sciences and Humanities, Australia and Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia.

There is limited evidence about emotional and behavioral responses in toddlers and preschoolers during the novel coronavirus (COVID-19) pandemic, particularly in Latin America. To assess associations between changes in movement behaviors (physical activity, screen time and sleeping) and emotional changes in toddlers and preschoolers during early stages of the pandemic in Chile. A cross-sectional study conducted from March 30th to April 27th, 2020. Read More

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Host Genetics and Antiviral Immune Responses in Adult Patients With Multisystem Inflammatory Syndrome.

Front Immunol 2021 31;12:718744. Epub 2021 Aug 31.

Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.

COVID-19 associated multisystem inflammatory syndrome (MIS) is a rare condition mostly affecting children but also adults (MIS-A). Although severe systemic inflammation and multiorgan dysfunction are hallmarks of the syndrome, the underlying pathogenesis is unclear. We aimed to provide novel immunological and genetic descriptions of MIS-A patients. Read More

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The Burden of Respiratory Viruses and Their Prevalence in Different Geographical Regions of India: 1970-2020.

Front Microbiol 2021 31;12:723850. Epub 2021 Aug 31.

Division of Molecular Biology, ICMR-National AIDS Research Institute, Pune, India.

As per the 2019 report of the National Health Portal of India, 41,996,260 cases and 3,740 deaths from respiratory infections were recorded across India in 2018. India contributes to 18% of the global population, with severe acute respiratory infection (SARI) as one of the prominent causes of mortality in children >5 years of age. Measures in terms of the diagnosis and surveillance of respiratory infections are taken up globally to discover their circulating types, detect outbreaks, and estimate the disease burden. Read More

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Animal Models for COVID-19: Hamsters, Mouse, Ferret, Mink, Tree Shrew, and Non-human Primates.

Front Microbiol 2021 31;12:626553. Epub 2021 Aug 31.

Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Fudan University, Shanghai, China.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus causing acute respiratory tract infection in humans. The virus has the characteristics of rapid transmission, long incubation period and strong pathogenicity, and has spread all over the world. Therefore, it is of great significance to select appropriate animal models for antiviral drug development and therapeutic effect evaluation. Read More

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Early COVID-19 Government Communication Is Associated With Reduced Interest in the QAnon Conspiracy Theory.

Front Psychol 2021 31;12:681975. Epub 2021 Aug 31.

Queensland University of Technology, Brisbane, QLD, Australia.

Does inadequate risk communication during uncertain times trigger the rise of conspiratorial ideas? We hypothesize that, where government COVID-19 risk communication started early, as measured by the number of days between the start of the communication campaign and the first case in the country, citizens are less likely to turn to conspiratorial explanations for the pandemic, which typically assign blame to powerful actors with secret interests. In Study 1a, we find strong support for our hypothesis in a global sample of 111 countries, using daily Google search volumes for QAnon as a measure of interest in QAnon, which is a conspiracy theory contending, among other things, that COVID-19 is a conspiracy orchestrated by powerful actors and aimed at repressing civil liberties. The effect is robust to a variety of sensitivity checks. Read More

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Anxious and Angry: Emotional Responses to the COVID-19 Threat.

Front Psychol 2021 31;12:676116. Epub 2021 Aug 31.

Department of Psychology, University of Amsterdam, Amsterdam, Netherlands.

The current coronavirus disease 2019 (COVID-19) pandemic elicits a vast amount of anxiety. In the current study, we investigated how anxiety related to COVID-19 is associated with support for and compliance with governmental hygiene measures, and how these are influenced by populist attitudes, anger at the government, and conspiracy mentalities. We conducted an online survey in April 2020 in four different countries (Germany, the Netherlands, Spain, and the UK; = 2,031) using a cross-sectional design. Read More

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Observing the Working Alliance in Videoconferencing Psychotherapy for Alcohol Addiction: Reliability and Validity of the Working Alliance Inventory Short Revised Observer.

Front Psychol 2021 31;12:647814. Epub 2021 Aug 31.

Human Sciences Institute, Psychology Department, Center for Research, Intervention, and Evaluation for Alcohol and Drugs, Federal University of Juiz de Fora, Juiz de Fora, Brazil.

The coronavirus disease-2019 (COVID-19) pandemic has affected the mental health and alcohol consumption of individuals. Videoconferencing psychotherapy has become a fundamental mode of treatment for people with alcohol use disorders. However, there are still doubts about its effectiveness and the therapeutic relationship. Read More

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The Gaps Between the Self and Professional Evaluation in Mental Health Assessment of COVID-19 Cluster Cases.

Front Psychol 2021 31;12:614193. Epub 2021 Aug 31.

Department of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China.

To analyze the discrepancy between self-rating and professional evaluation of mental health status in coronavirus disease 2019 (COVID-19) cluster cases. A total of 65 COVID-19 cluster cases admitted to Beijing Ditan Hospital Capital Medical University from June 14, 2020 to June 16, 2020 were included in the study. Mental health assessment was completed by self-rating and professional evaluation. Read More

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Progress in Traditional Chinese Medicine Against Respiratory Viruses: A Review.

Front Pharmacol 2021 31;12:743623. Epub 2021 Aug 31.

Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.

Respiratory viruses, such as severe acute respiratory syndrome coronavirus (SARS-CoV)-1, SARS-CoV-2, influenza A viruses, and respiratory syncytial virus, pose a serious threat to society. Based on the guiding principles of "holism" and "syndrome differentiation and treatment", traditional Chinese medicine (TCM) has unique advantages in the treatment of respiratory virus diseases owing to the synergistic effect of multiple components and targets, which prevents drug resistance from arising. According to TCM theory, there are two main strategies in antiviral treatments, namely "dispelling evil" and "fu zheng". Read More

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Identification of Novel Gene Signatures using Next-Generation Sequencing Data from COVID-19 Infection Models: Focus on Neuro-COVID and Potential Therapeutics.

Front Pharmacol 2021 31;12:688227. Epub 2021 Aug 31.

Center of Excellence in Genomic Medicine Research, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.

SARS-CoV-2 is the causative agent for coronavirus disease-19 (COVID-19) and belongs to the family Coronaviridae that causes sickness varying from the common cold to more severe illnesses such as severe acute respiratory syndrome, sudden stroke, neurological complications (Neuro-COVID), multiple organ failure, and mortality in some patients. The gene expression profiles of COVID-19 infection models can be used to decipher potential therapeutics for COVID-19 and related pathologies, such as Neuro-COVID. Here, we used the raw RNA-seq reads (Single-End) in quadruplicates derived using Illumina Next Seq 500 from SARS-CoV-infected primary human bronchial epithelium (NHBE) and mock-treated NHBE cells obtained from the Gene Expression Omnibus (GEO) (GSE147507), and the quality control (QC) was evaluated using the CLC Genomics Workbench 20. Read More

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Cardiovascular disease and COVID-19: a consensus paper from the ESC Working Group on Coronary Pathophysiology & Microcirculation, ESC Working Group on Thrombosis and the Association for Acute CardioVascular Care (ACVC), in collaboration with the European Heart Rhythm Association (EHRA).

Cardiovasc Res 2021 Sep 16. Epub 2021 Sep 16.

Department of Cardiology, 'Hippokration' General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.

The cardiovascular system is significantly affected in coronavirus disease-19 (COVID-19). Microvascular injury, endothelial dysfunction and thrombosis resulting from viral infection or indirectly related to the intense systemic inflammatory and immune responses are characteristic features of severe COVID-19. Pre-existing cardiovascular disease and viral load are linked to myocardial injury and worse outcomes. Read More

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September 2021

Host Serine Proteases: A Potential Targeted Therapy for COVID-19 and Influenza.

Front Mol Biosci 2021 30;8:725528. Epub 2021 Aug 30.

Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

The ongoing pandemic illustrates limited therapeutic options for controlling SARS-CoV-2 infections, calling a need for additional therapeutic targets. The viral spike S glycoprotein binds to the human receptor angiotensin-converting enzyme 2 (ACE2) and then is activated by the host proteases. Based on the accessibility of the cellular proteases needed for SARS-S activation, SARS-CoV-2 entrance and activation can be mediated by endosomal (such as cathepsin L) and non-endosomal pathways. Read More

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Models and Processes to Extract Drug-like Molecules From Natural Language Text.

Front Mol Biosci 2021 30;8:636077. Epub 2021 Aug 30.

Department of Computer Science, University of Chicago, Chicago, IL, United States.

Researchers worldwide are seeking to repurpose existing drugs or discover new drugs to counter the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A promising source of candidates for such studies is molecules that have been reported in the scientific literature to be drug-like in the context of viral research. However, this literature is too large for human review and features unusual vocabularies for which existing named entity recognition (NER) models are ineffective. Read More

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Dietary Habits and Lifestyle During Coronavirus Pandemic Lockdown: Experience From Lebanon.

Front Nutr 2021 30;8:730425. Epub 2021 Aug 30.

Department of Nutrition and Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.

This study aimed to examine the impact of quarantine on eating habits and lifestyle behaviors among the Lebanese adult population. A cross-sectional study was conducted using an online questionnaire designed on Google Forms between 3 June and 28 June 2020. The survey questions were adapted from the Short Food Frequency Questionnaire, the International Physical Activity Questionnaire Short Form, and the second version of the Copenhagen Psychosocial Questionnaire. Read More

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Food Safety Knowledge, Attitudes, and Practices Among Jordan Universities Students During the COVID-19 Pandemic.

Front Public Health 2021 30;9:729816. Epub 2021 Aug 30.

Department of Nutrition and Food Technology, Faculty of Agriculture, Jordan University of Science and Technology, Irbid, Jordan.

This study aimed to evaluate food safety knowledge, attitudes and practices (KAP) amongst university students in Jordan and changes in food-related behaviors during the COVID-19 pandemic. Correlation between food safety KAP scores and general characteristics of university students was also evaluated. A cross-sectional study was conducted where an Internet-based questionnaire was distributed through social media platforms. Read More

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Infodemic vs. Pandemic Factors Associated to Public Anxiety in the Early Stage of the COVID-19 Outbreak: A Cross-Sectional Study in China.

Jian Xu Cong Liu

Front Public Health 2021 30;9:723648. Epub 2021 Aug 30.

School of Media and Communication, Shanghai Jiao Tong University, Shanghai, China.

Every outbreak of an epidemic or pandemic disease is accompanied by the tsunami of information, which is also known as the infodemic. Infodemic makes it hard for people to find trustworthy sources and reliable guidance when they need it, and causes social panic about health, widens the gaps between races and regions, and even brings the social chaos all over the world. While most researchers and related parties made efforts to control the inaccurate information spreading online during the COVID-19 pandemic, the infodemic influence caused by the overload of accurate information were almost or completely ignored, and this will hinder the control of infodemic in future public health crises. Read More

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Effectiveness and Preparedness of Institutions' E-Learning Methods During the COVID-19 Pandemic for Residents' Medical Training in Saudi Arabia: A Pilot Study.

Front Public Health 2021 30;9:707833. Epub 2021 Aug 30.

Health and Welfare Units Administration, Technological, Educational Institute of Peloponnese, Kalamata, Greece.

Under the urgent circumstances of the COVID-19 pandemic, higher education institutions of an international scale have resorted to online education methods, exclusive or not. Among those, medical institutions are under double pressure, fighting the pandemic's effects and, at the same time providing efficient clinical training to their residents. The main aim of the study is to evaluate the preparedness of the educational institutions for the e-learning platform transition for the delivery of medical training and also to evaluate the overall satisfaction level of the participants with their e-learning experience. Read More

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Artemether, Artesunate, Arteannuin B, Echinatin, Licochalcone B and Andrographolide Effectively Inhibit SARS-CoV-2 and Related Viruses .

Front Cell Infect Microbiol 2021 30;11:680127. Epub 2021 Aug 30.

Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.

Since the first reported case caused by the novel coronavirus SARS-CoV-2 infection in Wuhan, COVID-19 has caused serious deaths and an ongoing global pandemic, and it is still raging in more than 200 countries and regions around the world and many new variants have appeared in the process of continuous transmission. In the early stage of the epidemic prevention and control and clinical treatment, traditional Chinese medicine played a huge role in China. Here, we screened out six monomer compounds, including artemether, artesunate, arteannuin B, echinatin, licochalcone B and andrographolide, with excellent anti-SARS-CoV-2 and anti-GX_P2V activity from Anti-COVID-19 Traditional Chinese Medicine Compound Library containing 389 monomer compounds extracted from traditional Chinese medicine prescriptions "three formulas and three drugs". Read More

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A Case of Multisystem Inflammatory Syndrome in a Pediatric Patient With Acute Appendicitis.

Cureus 2021 Aug 11;13(8):e17084. Epub 2021 Aug 11.

Pediatrics, Elmhurst Hospital Center, Icahn School of Medicine at Mount Sinai, New York, USA.

This case report details the clinical course of a 7-year-old patient with an initial presentation of acute appendicitis, who developed symptoms highly concerning multisystem inflammatory syndrome in children (MIS-C) after appendectomy. Despite appropriate management, the patient went on to develop left main coronary artery dilatation. Given the spectrum of clinical presentations and absence of pathognomonic findings or diagnostic tests for MIS-C, it is essential to maintain a high index of suspicion for MIS-C when pediatric patients first present with nonspecific gastrointestinal symptoms and recent exposure to coronavirus disease 2019 (COVID-19). Read More

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Editorial: Coronavirus Disease (COVID-19): Psychological Reactions to the Pandemic.

Front Psychol 2021 30;12:745941. Epub 2021 Aug 30.

Department of Economic Psychology, Johannes Kepler University of Linz, Linz, Austria.

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Patients' impressions of after-hours house-call services during the COVID-19 pandemic in Japan: a questionnaire-based observational study.

BMC Fam Pract 2021 Sep 15;22(1):184. Epub 2021 Sep 15.

Department of Health Services Research, University of Tsukuba, 1-1-1 Tenno-dai, Tsukuba, Ibaraki, 305-8575, Japan.

Background: Access to healthcare has been strongly affected by the coronavirus disease 2019 (COVID-19) pandemic, which has raised concerns about the increased risk of delays in receiving medical care. This study aimed to assess the patients' impressions of after-hour house-call (AHHC) medical services during the COVID-19 pandemic using a patient questionnaire.

Methods: This was a cross-sectional observational study of anonymized medical record data and internet-based questionnaires from patients who used AHHC medical services from April 2020 to January 2021. Read More

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September 2021

Laboratory-Generated DNA Can Cause Anomalous Pathogen Diagnostic Test Results.

Microbiol Spectr 2021 Sep 15:e0031321. Epub 2021 Sep 15.

Department of Genetics, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.

The coronavirus disease 2019 (COVID-19) pandemic has brought about the unprecedented expansion of highly sensitive molecular diagnostics as a primary infection control strategy. At the same time, many laboratories have shifted focus to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) research and diagnostic development, leading to large-scale production of SARS-CoV-2 nucleic acids that can interfere with these tests. We have identified multiple instances, in independent laboratories, in which nucleic acids generated in research settings are suspected to have caused researchers to test positive for SARS-CoV-2 in surveillance testing. Read More

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September 2021

UK Healthcare Workers' Experiences of Major System Change in Elective Surgery During the COVID-19 Pandemic: Reflections on Rapid Service Adaptation.

Int J Health Policy Manag 2021 Sep 1. Epub 2021 Sep 1.

Department of Targeted Intervention, University College London, London, UK.

Background: The coronavirus disease 2019 (COVID-19) pandemic disrupted the delivery of elective surgery in the United Kingdom. The majority of planned surgery was cancelled or postponed in March 2020 for the duration of the first wave of the pandemic. We investigated the experiences of staff responsible for delivering rapid changes to surgical services during the first wave of the pandemic in the United Kingdom, with the aim of developing lessons for future major systems change (MSC). Read More

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September 2021

Bilateral Facial Nerve Palsy and COVID-19 Vaccination: Causation or Coincidence?

Cureus 2021 Aug 31;13(8):e17602. Epub 2021 Aug 31.

Neuro-endovascular Surgery, Southeast Health Medical Center, Dothan, USA.

Bell's palsy is a mononeuropathy of the facial nerve that typically causes unilateral facial paralysis. The incidence of unilateral Bell's palsy is not uncommon, but sequential or simultaneous bilateral Bell's palsy is exceedingly rare. While unilateral Bell's palsy is oftentimes idiopathic, bilateral Bell's palsy is almost exclusively explained by an identifiable trigger. Read More

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The association between the belief in coronavirus conspiracy theories, miracles, and the susceptibility to conjunction fallacy.

Appl Cogn Psychol 2021 Sep-Oct;35(5):1344-1348. Epub 2021 Jul 6.

Institute of Psychology University of Graz Graz Austria.

Previous research has shown that people who endorse conspiracy theories are more prone to the conjunction fallacy: the tendency to perceive conjunct events as more probable than constituent events. The present study examined the relationship between specific beliefs (belief in conspiracy theories, religiosity) and the susceptibility to conjunction errors (CEs) in specific domains. A total of 500 participants was presented with brief scenarios from the domains "coronavirus conspiracy," "miraculous healing," and a control condition. Read More

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COVID-19 Infection in Octagenarian Patients: Imaging Aspects and Clinical Correlations.

Gerontology 2021 Aug 5:1-11. Epub 2021 Aug 5.

Department of Radiology and Diagnostic Imaging at Prevent Senior, São Paulo, Brazil.

Introduction: Computed tomography (CT) of the chest, although not a screening test or diagnosis of infection with the new coronavirus, has a fundamental role in assessing the extent of lung involvement and complications such as pleural effusion. Considering the higher morbidity and mortality of elderly patients due to this infection, the objective of this study was to evaluate the imaging aspects and clinical correlations of an extreme age (≥80 years) with a confirmed diagnosis for COVID-19.

Methods: This was a retrospective and single-center cohort study. Read More

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How is the COVID-19 pandemic shaping transportation access to health care?

Transp Res Interdiscip Perspect 2021 Jun 12;10:100338. Epub 2021 Mar 12.

Department of Health Policy & Management, UCLA Fielding School of Public Health, Los Angeles, CA, USA.

The Coronavirus disease 19 (COVID-19) pandemic has disrupted both transportation and health systems. While about 40% of Americans have delayed seeking medical care during the pandemic, it remains unclear to what extent transportation is contributing to missed care. To understand the relationship between transportation and unmet health care needs during the pandemic, this paper synthesizes existing knowledge on transportation patterns and barriers across five types of health care needs. Read More

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Methods to Identify Immunogenic Peptides in SARS-CoV-2 Spike and Protective Monoclonal Antibodies in COVID-19 Patients.

Small Methods 2021 Jul 19;5(7):2100058. Epub 2021 Jun 19.

Department of Microbiology Immunology & Molecular Genetics University of California Los Angeles Los Angeles CA 90095 USA.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the associated COVID-19 diseases are an emerging threat to global public health. Although considerable scientific research on the immune, especially antibody, responses to SARS-CoV-2 infection have been conducted, additional dominant epitopes and protective antibodies are needed for diagnosis and treatment of COVID-19 patients. Here, two different phage libraries are used to identify immunogenic epitopes across the spike protein and monoclonal antibodies from COVID-19 patients. Read More

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