4 results match your criteria abortive rabv

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Evidence of Arctic Fox Survival following Exposure to Rabies Virus.

J Wildl Dis 2021 Nov 23. Epub 2021 Nov 23.

US Department of Agriculture, National Wildlife Research Center, 4101 Laporte Avenue, Fort Collins, Colorado 80521, USA.

The arctic fox variant of the rabies virus (RABV) is enzootic in the circumpolar north. Reports of abortive RABV exposures motivated a retrospective analysis of sera from 41 arctic foxes captured at Karrak Lake in Nunavut, Canada, during 2011-2015. Estimated RABV antibody prevalence among foxes was 14% (95% confidence interval, 7-28%). Read More

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November 2021

Astrocyte Infection during Rabies Encephalitis Depends on the Virus Strain and Infection Route as Demonstrated by Novel Quantitative 3D Analysis of Cell Tropism.

Cells 2020 02 11;9(2). Epub 2020 Feb 11.

Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health, Institute of Molecular Virology and Cell Biology, 17493 Greifswald-Insel Riems, Germany.

Although conventional immunohistochemistry for neurotropic rabies virus (RABV) usually shows high preference for neurons, non-neuronal cells are also potential targets, and abortive astrocyte infection is considered a main trigger of innate immunity in the CNS. While in vitro studies indicated differences between field and less virulent lab-adapted RABVs, a systematic, quantitative comparison of astrocyte tropism in vivo is lacking. Here, solvent-based tissue clearing was used to measure RABV cell tropism in infected brains. Read More

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February 2020

Lab-Attenuated Rabies Virus Causes Abortive Infection and Induces Cytokine Expression in Astrocytes by Activating Mitochondrial Antiviral-Signaling Protein Signaling Pathway.

Front Immunol 2017 19;8:2011. Epub 2018 Jan 19.

State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.

Rabies is an ancient disease but remains endemic in most parts of the world and causes approximately 59,000 deaths annually. The mechanism through which the causative agent, rabies virus (RABV), evades the host immune response and infects the host central nervous system (CNS) has not been completely elucidated thus far. Our previous studies have shown that lab-attenuated, but not wild-type (wt), RABV activates the innate immune response in the mouse and dog models. Read More

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January 2018

Host immunity to repeated rabies virus infection in big brown bats.

J Gen Virol 2010 Sep 2;91(Pt 9):2360-6. Epub 2010 Jun 2.

Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention , Atlanta, GA 30333, USA.

Bats are natural reservoirs for the majority of lyssaviruses globally, and are unique among mammals in having exceptional sociality and longevity. Given these facets, and the recognized status of bats as reservoirs for rabies viruses (RABVs) in the Americas, individual bats may experience repeated exposure to RABV during their lifetime. Nevertheless, little information exists with regard to within-host infection dynamics and the role of immunological memory that may result from abortive RABV infection in bats. Read More

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September 2010
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