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Management of Hypertension and Blood Pressure Dysregulation in Patients with Parkinson's Disease-a Systematic Review.

Curr Hypertens Rep 2021 May 7;23(5):26. Epub 2021 May 7.

Cardiology Department, Hippokration General Hospital, Athens, Greece.

Purpose Of Review: The aim of this review article was to summarize the cardiovascular and blood pressure profile regarding Parkinson disease patients and to provide an update on the recent advancements in the field of the diagnosis and management of blood pressure abnormalities in these patients. Our goal was to guide physicians to avoid pitfalls in current practice while treating patients with Parkinson disease and blood pressure abnormalities. For this purpose, we searched bibliographic databases (PubMed, Google Scholar) for all publications published on blood pressure effects in Parkinson disease until May 2020. Read More

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Pediatric dental outcomes among children exposed to chemotherapy in utero.

Int J Paediatr Dent 2021 May 7. Epub 2021 May 7.

Department of Obstetrics and Gynecology, Cooper University Hospital, 1 Cooper Plaza, Camden, NJ, 08103, USA.

Aim: Our study prospectively evaluated dental development in children exposed to chemotherapy in utero compared to unexposed controls.

Design: Women who received chemotherapy while pregnant were enrolled in a research registry. After age two years, each child's dentist was asked to complete a questionnaire about dental abnormalities and malformations as well as for their unexposed siblings. Read More

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Suspected acquired narcolepsy in 8 dogs.

J Vet Intern Med 2021 May 7. Epub 2021 May 7.

Evidensia Small Animal Hospital 'Hart van Brabant', Waalwijk, The Netherlands.

Background: Acquired narcolepsy has rarely been reported in veterinary medicine.

Objective: To describe the presentation, clinicopathological features, diagnostic imaging findings, and management of dogs with suspected-acquired narcolepsy.

Animals: Eight dogs with clinical features consistent with acquired narcolepsy. Read More

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[Treatment and prevention of chronic cystitis in women].

Urologiia 2021 May(2):51-56

FGBOU VO Altai State Medical University of the Ministry of Health of Russia, Barnaul, Russia.

Aim: to evaluate the efficiency of the dietary supplement NefroBest in women with chronic cystitis.

Materials And Methods: On the basis of the Department of Urology and Nephrology of the Altai State Medical University and the urological department of the NUZ CH "RJD Medicine", Barnaul, from September 2019 to August 2020 a total of 40 women with chronic cystitis were treaeted. Depending on the type of treatment, all women were divided into the main and control groups, each of 20 people. Read More

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Porcine Acellular Dermal Matrix Increases Fat Survival Rate after Fat Grafting in Nude Mice.

Aesthetic Plast Surg 2021 May 6. Epub 2021 May 6.

Department of Burn and Plastic Surgery, Second People's Hospital of Shenzhen, First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, 518000, Guangdong, China.

Background: Autologous fat grafts have been widely in use for reconstruction, contour abnormalities, and cosmetic surgeries. However, the grafted fat one-year survival rate is unpredictable and always low (20%-80%). Standardizing the existing transplantation technology is difficult due to the limiting conditions. Read More

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Peripheral Gangerene, an Unusual Presentation of Infantile Kawasaki: A Case Report and Literature Review.

Case Rep Rheumatol 2021 13;2021:6629405. Epub 2021 Apr 13.

Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Diagnosing infantile Kawasaki disease with atypical symptoms is difficult, and it also has higher risk of coronary abnormalities which is one of the most common complications of KD. Other complications such as pericardial effusion, mitral insufficiency, congestive heart failure, myocardial systolic dysfunction, and systemic vasculitis were also reported. Peripheral gangrene and necrosis are among the rare complications of this systemic vasculitis. Read More

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The Architecture of Circulating Immune Cells Is Dysregulated in People Living With HIV on Long Term Antiretroviral Treatment and Relates With Markers of the HIV-1 Reservoir, Cytomegalovirus, and Microbial Translocation.

Front Immunol 2021 19;12:661990. Epub 2021 Apr 19.

Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.

Long-term changes in the immune system of successfully treated people living with HIV (PLHIV) remain incompletely understood. In this study, we assessed 108 white blood cell (WBC) populations in a cohort of 211 PLHIV on stable antiretroviral therapy and in 56 HIV-uninfected controls using flow cytometry. We show that marked differences exist in T cell maturation and differentiation between PLHIV and HIV-uninfected controls: PLHIV had reduced percentages of CD4+ T cells and naïve T cells and increased percentages of CD8+ T cells, effector T cells, and T helper 17 (Th17) cells, together with increased Th17/regulatory T cell (Treg) ratios. Read More

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The Updated Role of Ultrasound in Assessing Dermatological Manifestations in Systemic Sclerosis.

Open Access Rheumatol 2021 28;13:79-91. Epub 2021 Apr 28.

Unit of Pulmonology, University Hospital of Trieste, Trieste, Italy.

Systemic sclerosis (SSc), an autoimmune connective tissue disease, characterized by skin fibrosis, increased dermal thickness and microvascular involvement. Fibroblasts and myofibroblasts deposit excessive amounts of collagenous and non-collagenous extracellular matrix components in the skin. This leads to microvascular abnormalities and Raynaud's phenomenon, with painful digital ulcers (DU) at the fingertips adding to patient discomfort. Read More

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The long-term prognosis of hippocampal neurogenesis and behavioral changes of offspring from rats exposed to valproic acid during pregnancy.

Neuropsychopharmacol Rep 2021 May 5. Epub 2021 May 5.

Department of Psychiatry, Juntendo Koshigaya Hospital, Saitama, Japan.

Aim: In pregnant women with epilepsy, it is essential to balance maternal safety and the potential teratogenicity of anticonvulsants. Recently, growing evidence has indicated that valproic acid (VPA) can produce postnatal congenital malformations and impair cognitive function. However, the mechanisms underlying cognitive dysfunction in long-term prognoses remain unclear. Read More

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Wernicke Encephalopathy in an Elderly Patient Due to Chronic Malnutrition From an Atypical Diet.

Cureus 2021 Mar 31;13(3):e14210. Epub 2021 Mar 31.

Psychiatry, Lewis Gale Medical Center, Salem, USA.

Wernicke encephalopathy has traditionally been associated with chronic alcohol abuse leading to thiamine deficiency. Clinical symptoms include mentation change, gait ataxia, and oculomotor abnormalities. However, it is often an underdiagnosed condition in patients suffering from chronic malnutrition, especially in the West. Read More

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Validation of CIP2A as a Biomarker of Subsequent Disease Progression and Treatment Failure in Chronic Myeloid Leukaemia.

Cancers (Basel) 2021 Apr 29;13(9). Epub 2021 Apr 29.

Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool L69 3GA, UK.

Background: It would be clinically useful to prospectively identify the risk of disease progression in chronic myeloid leukaemia (CML). Overexpression of cancerous inhibitor of protein phosphatase 2A (PP2A) (CIP2A) protein is an adverse prognostic indicator in many cancers.

Methods: We examined CIP2A protein levels in diagnostic samples from the SPIRIT2 trial in 172 unselected patients, of whom 90 received imatinib and 82 dasatinib as first-line treatment. Read More

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Safety, Tolerability, and Effect of Nusinersen in Non-ambulatory Adults With Spinal Muscular Atrophy.

Front Neurol 2021 16;12:650532. Epub 2021 Apr 16.

Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, United States.

Investigation of the safety, tolerability, and treatment effect of nusinersen treatment in non-ambulatory adults with spinal muscular atrophy (SMA). Non-ambulatory individuals, aged 18 years or older with genetically confirmed 5q SMA were enrolled. In participants with spinal fusion, fluoroscopy guided cervical C1-C2 lateral approach was used. Read More

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Emerging Disease-Modifying Therapies in Neurodegeneration With Brain Iron Accumulation (NBIA) Disorders.

Front Neurol 2021 15;12:629414. Epub 2021 Apr 15.

Department of Neurology With Friedrich Baur Institute, University Hospital of Ludwig-Maximilians-Universität München, Munich, Germany.

Neurodegeneration with Brain Iron Accumulation (NBIA) is a heterogeneous group of progressive neurodegenerative diseases characterized by iron deposition in the globus pallidus and the substantia nigra. As of today, 15 distinct monogenetic disease entities have been identified. The four most common forms are pantothenate kinase-associated neurodegeneration (PKAN), phospholipase A2 group VI (PLA2G6)-associated neurodegeneration (PLAN), beta-propeller protein-associated neurodegeneration (BPAN) and mitochondrial membrane protein-associated neurodegeneration (MPAN). Read More

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Plasma Ferritin as Marker of Macrophage Activation-Like Syndrome in Critically Ill Patients With Community-Acquired Pneumonia.

Crit Care Med 2021 May 3. Epub 2021 May 3.

Center for Experimental and Molecular Medicine (CEMM), Amsterdam University Medical Centers - Location AMC, University of Amsterdam, Amsterdam, The Netherlands. Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Centers, Amsterdam, The Netherlands. Respiratory Medicine and Experimental Immunology, Amsterdam University Medical Centers - Location AMC, University of Amsterdam, Amsterdam, The Netherlands. Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht, the Netherlands. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands. Julius Center for Health Sciences and Primary Care, University of Utrecht, Utrecht, The Netherlands. Department of Intensive Care & Laboratory of Experimental Intensive Care and Anesthesiology, Amsterdam University Medical Centers - Location AMC, University of Amsterdam, Amsterdam, The Netherlands. Mahidol-Oxford Tropical Medicine Research Unit (MORU), Mahidol University, Bangkok, Thailand. Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom. Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam University Medical Centers - Location AMC, University of Amsterdam, Amsterdam, The Netherlands. Division of Infectious Diseases, Amsterdam University Medical Centers - Location AMC, University of Amsterdam, Amsterdam, The Netherlands.

Objectives: Plasma ferritin levels above 4,420 ng/mL have been proposed as a diagnostic marker for macrophage activation-like syndrome in sepsis and used for selection of sepsis patients for anti-inflammatory therapy. We here sought to determine the frequency, presentation, outcome, and host response aberrations of macrophage activation-like syndrome, as defined by admission ferritin levels above 4,420 ng/mL, in critically ill patients with community-acquired pneumonia.

Design: A prospective observational cohort study. Read More

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Application of ultrasound elastography in obstetrics and gynecology

Orv Hetil 2021 05 2;162(18):690-695. Epub 2021 May 2.

3 Eastern Virginia Medical School, Department of Obstetrics and Gynecology, Division of Female Pelvic Medicine and Reconstructive Surgery, Norfolk, VA, United States of America.

Összefoglaló. Az ultrahang-elasztográfia az elmúlt évek során egyre növekvő figyelmet kapott a lágyszövetek elaszticitásának vizsgálatában. A módszer használatát az teszi szükségessé, hogy egyes, a mechanikai tulajdonságaikban különböző szövetek hasonló echogenitásúak lehetnek, valamint hogy egy adott szövet megváltozott struktúrája vagy mechanikai tulajdonsága nem minden esetben jár együtt a szövet hagyományos ultrahangképének megváltozásával. Read More

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Motor speech disorders in the nonfluent, semantic and logopenic variants of primary progressive aphasia.

Cortex 2021 Apr 2;140:66-79. Epub 2021 Apr 2.

Center for Cognitive Disorders, Department of Psychiatry and Psychotherapy, Technische Universität München, München, Germany; Munich Cluster for Systems Neurology (SyNergy), München, Germany.

Objective: Motor speech disorders (MSDs) are characteristic for nonfluent primary progressive aphasia (nfvPPA). In primary progressive aphasia (PPA) of the semantic (svPPA) and of the logopenic type (lvPPA), speech motor function is considered typically intact. However, knowledge on the prevalence of MSDs in svPPA and lvPPA is mainly based on studies with a priori knowledge of PPA syndrome diagnosis. Read More

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Real-World Outcomes of Patients with Acute Myeloid Leukemia in Taiwan: A Nationwide Population-Based Study, 2011-2015.

Clin Lymphoma Myeloma Leuk 2021 Mar 29. Epub 2021 Mar 29.

Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Department of Hematological Oncology, National Taiwan University Cancer Center, Taipei, Taiwan. Electronic address:

Background: Acute myeloid leukemia (AML) is a hematological malignancy originating from myeloid precursor cells, with different cytogenetic abnormalities, genetic mutations and diverse clinical prognoses. We investigated the clinical characteristics, treatment patterns, and outcomes of adult AML patients in Taiwan.

Materials And Methods: We retrospectively included 3851 patients with AML in the Taiwan Cancer Registry Database from 2011 to 2015. Read More

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Repair of Defects in the Scalp and Face With Expanded Superficial Temporal Artery Flaps: A Single-Center Retrospective Study.

J Craniofac Surg 2021 Feb 9. Epub 2021 Feb 9.

*Department of Plastic Surgery, Jinling Hospital, Bengbu Medical College, Bengbu, Anhui †Department of Burn and Plastic Surgery and Vascular Biology Lab, Jinling Hospital ‡Department of Burn and Plastic Surgery and Vascular Biology Lab, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.

Background And Objective: Defects resulted from the removal of large scars, benign tumors, severe pigmentation abnormalities, and vascular malformations, etc., in the scalp and face need to be repaired to restore the appearance. Here, the authors introduced the application of various expanded superficial temporal artery (STA) flaps in the repair of above defects. Read More

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February 2021

A Case of Extreme Skeletal Class III Malocclusion Beyond the Envelope of Discrepancy, Managed Effectively by a Modified Ortho-Surgical Protocol.

J Maxillofac Oral Surg 2021 Jun 27;20(2):201-218. Epub 2020 Mar 27.

Command Military Dental Centre (Northern Command), Udhampur, Jammu and Kashmir India.

Introduction: Correction of a severe anteroposterior skeletal discrepancy, as described in this case of extreme skeletal class III malocclusion, can be quite challenging and fraught with difficulties. Conventional, single-stage bi-jaw orthognathic surgery with pre-and post-surgical orthodontics is associated with drawbacks such as the risk of relapse and an unsatisfactory overall long-term outcome, with persisting occlusal discrepancies and skeletal abnormalities, especially when the magnitude of skeletal correction required is large. Excessive mandibular setback can restrict tongue space, cause narrowing of posterior airway and pharyngeal space, and be prone to relapse from the forward pterygomasseteric muscle pull, while large maxillary advancements are often accompanied by wound dehiscence and bone exposure at the site of pterygomaxillary disjunction, delayed union or malunion at the osteotomy and disjunction sites, and risk of relapse due to backward palatopharyngeal muscle pull. Read More

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Dravet Syndrome-The Polish Family's Perspective Study.

J Clin Med 2021 Apr 28;10(9). Epub 2021 Apr 28.

Clinic of Paediatric Neurology, National Research Institute of Mother and Child, 01-211 Warsaw, Poland.

Aim: The aim of the paper is to study the prevalence of Dravet Syndrome (DS) in the Polish population and indicate different factors other than seizures reducing the quality of life in such patients.

Method: A survey was conducted among caregivers of patients with DS by the members of the Polish support group of the Association for People with Severe Refractory Epilepsy DRAVET.PL. Read More

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Feasibility and safety of Remdesivir in SARS-CoV2 infected renal transplant recipients: A retrospective cohort from a developing nation.

Transpl Infect Dis 2021 Apr 29:e13629. Epub 2021 Apr 29.

Department of Nephrology and Clinical Transplantation, Institute of Kidney Diseases and Research Center, Dr HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad, India.

Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection has drastically impacted the transplant communities. Remdesivir (RDV) has shown some promising results in coronavirus disease (COVID-19) albeit with low certainty. Data in kidney transplant recipients (KTR) is still lacking. Read More

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Krebs von den Lungen 6 (KL-6) as a marker for disease severity and persistent radiological abnormalities following COVID-19 infection at 12 weeks.

PLoS One 2021 29;16(4):e0249607. Epub 2021 Apr 29.

Academic Respiratory Unit, North Bristol NHS Trust, Bristol, United Kingdom.

Introduction: Acute presentations of COVID-19 infection vary, ranging from asymptomatic carriage through to severe clinical manifestations including acute respiratory distress syndrome (ARDS). Longer term sequelae of COVID-19 infection includes lung fibrosis in a proportion of patients. Krebs von den Lungen 6 (KL-6) is a mucin like glycoprotein that has been proposed as a marker of pulmonary epithelial cell injury. Read More

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Genetic etiologies associated with infantile hydrocephalus in a Chinese infantile cohort.

World J Pediatr 2021 Apr 29. Epub 2021 Apr 29.

Department of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.

Background: Infantile hydrocephalus (IHC) is commonly related to other central nervous system diseases, which may have adverse effects on prognosis. The causes of IHC are heterogeneous, and the genetic etiologies are not fully understood. This study aimed to analyze the genetic etiologies of an IHC cohort. Read More

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Is the Psychopathic Brain an Artifact of Coding Bias? A Systematic Review.

Front Psychol 2021 12;12:654336. Epub 2021 Apr 12.

Irving K. Barber School of Arts and Sciences, University of British Columbia, Kelowna, BC, Canada.

Questionable research practices are a well-recognized problem in psychology. Coding bias, or the tendency of review studies to disproportionately cite positive findings from original research, has received comparatively little attention. Coding bias is more likely to occur when original research, such as neuroimaging, includes large numbers of effects, and is most concerning in applied contexts. Read More

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Utilisation of optical coherence tomography and optical coherence tomography angiography to assess retinal neovascularisation in diabetic retinopathy.

Eye (Lond) 2021 Apr 28. Epub 2021 Apr 28.

Newcastle Eye Centre, Royal Victoria Infirmary, Newcastle, UK.

Purpose: To evaluate the use of optical coherence tomography angiography (OCTA), structural OCT and fundus fluorescein angiography (FFA) to distinguish neovascularisation elsewhere (NVE) from intra retinal microvascular abnormalities (IRMA) and their use in early detection and possible risk assessment for vitreous haemorrhage.

Methods: A cross-sectional study of a consecutive series of patients with suspected NVE and IRMA using clinical examination and FFA, were examined further with OCT and OCTA. Treated and untreated eyes were also compared. Read More

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Neonatal hyperinsulinism in transient and classical forms of tyrosinemia.

Orphanet J Rare Dis 2021 Apr 28;16(1):190. Epub 2021 Apr 28.

Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, Box 1616, New York, NY, 10029, USA.

Background: The spectrum of disorders associated with hyperinsulinemic hypoglycemia (HHI) has vastly increased over the past 20 years with identification of molecular, metabolic and cellular pathways involved in the regulation of insulin secretion and its actions. Hereditary tyrosinemia (HT1) is a rare metabolic disorder associated with accumulation of toxic metabolites of the tyrosine pathway due to a genetically mediated enzyme defect of fumarylacetoacetate hydrolase. Transient tyrosinemia of the newborn (TTN) is a benign condition with a maturational defect of the enzymes associated with tyrosine metabolism without any genetic abnormalities. Read More

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Ellagic Acid Prevents Ca Dysregulation and Improves Functional Abnormalities of Ventricular Myocytes via Attenuation of Oxidative Stress in Pathological Cardiac Hypertrophy.

Cardiovasc Toxicol 2021 Apr 28. Epub 2021 Apr 28.

Department of Biophysics, Akdeniz University Faculty of Medicine, Antalya, Turkey.

The aim of this study was to investigate whether ellagic acid (EA) treatment can prevent changes in contractile function and Ca regulation of cardiomyocytes in pathologic cardiac hypertrophy. Groups were assigned as Con group; an ISO group in which the rats received isoproterenol alone (5 mg/kg/day); and an ISO + EA group in which the rats received isoproterenol and EA (20 mg/kg/day) for 4 weeks. Subsequently, fractional shortening, intracellular Ca signals, and L-type Ca currents of isolated ventricular myocytes were recorded. Read More

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Policaptil Gel Retard in adult subjects with the metabolic syndrome: Efficacy, safety, and tolerability compared to metformin.

Diabetes Metab Syndr 2021 Apr 8;15(3):901-907. Epub 2021 Apr 8.

Campania University "Luigi Vanvitelli", Naples, Italy; Nefrocenter Research Network & Nyx Research Start-Up, Naples, Italy.

Background: Policaptil Gel Retard® (PGR), is a new macromolecule complex based on polysaccharides slowing the rate of carbohydrate and fat absorption. It proved to significantly reduce body weight, acanthosis nigricans expression, HbA1c levels, and glucose metabolism abnormalities in obese, hyper-insulinemic adolescents. No such data are available for adults. Read More

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ELECTROPHYSIOLOGICAL STUDY OF THE TIBIAL NERVE ACROSS THE TARSAL TUNNEL IN DISTAL SYMMETRIC DIABETIC POLYNEUROPATHY.

Am J Phys Med Rehabil 2021 Apr 14. Epub 2021 Apr 14.

EMG Service, Local Health Unit Toscana Sud Est, Siena, Italy Department of Medical, Surgical and Neurological Sciences, University of Siena, Italy.

Objective: To demonstrate abnormalities of motor conduction of the tibial nerve across the tarsal tunnel (TT) in type 2 diabetes.

Design: 124 consecutive patients (mean age 66.6 years, 62. Read More

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Nusinersen treatment in adult patients with spinal muscular atrophy: a safety analysis of laboratory parameters.

J Neurol 2021 Apr 25. Epub 2021 Apr 25.

Department of Neurology, University Hospital Essen, Hufelandstr. 55, 45147, Essen, Germany.

Background: Nusinersen is an intrathecally administered antisense oligonucleotide (ASO) that improves motor function in patients with spinal muscular atrophy (SMA). In addition to efficacy, the safety of a therapy is the decisive factor for the success of the treatment. For some ASOs, various organ toxicities have been described, such as thrombocytopenia, renal and liver impairment, or coagulation abnormalities. Read More

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