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Effects of permanent cardiac pacing on ventricular repolarization when compared to cardioneuroablation.

J Electrocardiol 2021 Apr 21;67:13-18. Epub 2021 Apr 21.

Kansas City Heart Rhythm Institute and Research Foundation, Overland Park, KS, USA.

Introduction: The impact of cardioneuroablation (CNA) on ventricular repolarization by using corrected QT interval (QTc) measurements has been recently demonstrated. The effects of cardiac pacing (CP) on ventricular repolarization have not been studied in patients with vasovagal syncope (VVS). We sought to compare ventricular repolarization effects of CNA (group 1) with CP (group 2) in patients with VVS. Read More

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Interatrial Septal Tachycardias Following Atrial Fibrillation Ablation or Cardiac Surgery: Electrophysiologic Features and Ablation Outcomes.

Heart Rhythm 2021 May 10. Epub 2021 May 10.

Electrophysiology Section, Hospital of the University of Pennsylvania, Philadelphia, USA. Electronic address:

Background: Interatrial septal tachycardias (IAS-AT) following atrial fibrillation (AF) ablation or cardiac surgery are rare and their management is challenging.

Objective: To investigate the electrophysiologic features and outcomes associated with catheter ablation of IAS-AT.

Methods: We screened 338 patients undergoing catheter ablation of ATs following AF ablation or cardiac surgery. Read More

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Generation of mitochondrial reactive oxygen species is controlled by ATPase inhibitory factor 1 and regulates cognition.

PLoS Biol 2021 May 13;19(5):e3001252. Epub 2021 May 13.

Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain.

The mitochondrial ATP synthase emerges as key hub of cellular functions controlling the production of ATP, cellular signaling, and fate. It is regulated by the ATPase inhibitory factor 1 (IF1), which is highly abundant in neurons. Herein, we ablated or overexpressed IF1 in mouse neurons to show that IF1 dose defines the fraction of active/inactive enzyme in vivo, thereby controlling mitochondrial function and the production of mitochondrial reactive oxygen species (mtROS). Read More

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Integrative methylome-transcriptome analysis unravels cancer cell vulnerabilities in infant MLL-rearranged B-cell acute lymphoblastic leukemia.

J Clin Invest 2021 May 13. Epub 2021 May 13.

Josep Carreras Leukemia Research Institute-Campus Clinic, University of Barcelona, Barcelona, Spain.

B-cell acute lymphoblastic leukemia (B-ALL) is the most common childhood cancer. As predicated by its prenatal origin, infant B-ALL (iB-ALL) shows an exceptionally silent DNA mutational landscape, suggesting that alternative epigenetic mechanisms may substantially contribute to its leukemogenesis. Here, we have integrated genome-wide DNA methylome and transcriptome data from 69 patients with de novo MLL-rearranged (MLLr) and non-MLLr iB-ALL leukemias uniformly treated according to Interfant-99/06 protocol. Read More

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A stereotactic frame-based drill guide-aided setting for laser interstitial thermal therapy.

Acta Neurochir (Wien) 2021 May 13. Epub 2021 May 13.

Department of Neurosurgery, University Hospital Zurich, Frauenklinikstrasse 10, 8091, Zurich, Switzerland.

Background: Magnetic resonance imaging (MRI)-guided laser interstitial thermal therapy (MRIgLITT) was demonstrated to be a viable neurosurgical tool. Apart from its variety of indications, different operative and technical nuances exist. In the present report, for the first time, the use and ability of a traditional Riechert-Mundinger (RM) stereotactic system combined with a novel drill guide kit for MRIgLITT are described. Read More

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Association between functional mitral regurgitation and recurrence of paroxysmal atrial fibrillation following catheter ablation: a prospective cohort study.

J Int Med Res 2021 May;49(5):3000605211014375

Department of Cardiology, Shanghai General Hospital, Shanghai, China.

Objective: The present study aimed to investigate the effect of functional mitral regurgitation (FMR) on recurrence of paroxysmal atrial fibrillation (PAF) in patients undergoing radiofrequency catheter ablation.

Methods: This prospective cohort study comprised 107 patients with PAF. The patients were divided into the FMR and non-FMR groups. Read More

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Tissue Systems Pathology Test Objectively Risk Stratifies Barrett's Esophagus Patients With Low-Grade Dysplasia.

Am J Gastroenterol 2021 Apr;116(4):675-682

1Department of Gastroenterology & Hepatology, Amsterdam University Medical Centers, location Academic Medical Center, Amsterdam, the Netherlands; 2Cernostics, Pittsburgh, Pennsylvania, USA; 3Department of Gastroenterology & Hepatology, Amsterdam University Medical Centers, location VUmc, Amsterdam, the Netherlands; 4Department of Pathology, University Medical Center, Utrecht, the Netherlands; 5Department of Pathology, Pathology DNA-BV, St. Antonius Hospital, Nieuwegein, the Netherlands; 6Department of Pathology, Amsterdam University Medical Centers, location Academic Medical Center, Amsterdam, the Netherlands.

Introduction: Low-grade dysplasia (LGD) is the best predictor of neoplastic progression in Barrett's esophagus (BE). Most LGD cases are downstaged to nondysplastic (ND) BE on expert pathologist review, which is prone to interobserver variation and not widely available. Recent studies indicate that a risk prediction assay (TissueCypher) risk stratifies patients with NDBE for neoplastic progression. Read More

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A near-infrared light-excitable immunomodulating nano-photosensitizer for effective photoimmunotherapy.

Biomater Sci 2021 May 13. Epub 2021 May 13.

Key Laboratory of Functional Polymer Materials of Ministry of Education, College of Chemistry, Nankai University; State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China.

Photodynamic therapy has great potential for tumor ablation and the activation of antitumor immune responses. However, its overall therapeutic efficiency is often limited by the immunosuppressive tumor microenvironment. We developed a near-infrared light-excitable immunomodulating nano-photosensitizer (NeINP) that can improve reactive oxygen species production and regulate the immunosuppressive TME to improve photoimmunotherapy. Read More

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Is cardiac magnetic resonance imaging a game changer in re-ablation of atrial fibrillation?-Authors' reply.

Europace 2021 May 13. Epub 2021 May 13.

Department of Cardiology, Cardiovascular Clinical Institute, UFA (Unitat de Fibril.laciò Auricular de l'Hospital Clìnic), Hospital Clìnic, Universitat de Barcelona, C/Villarroel 170, 08036 Barcelona, Spain.

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Genetics of atrial fibrillation - practical applications for clinical management: If not now, when and how?

Cardiovasc Res 2021 May 12. Epub 2021 May 12.

Department of Cardiology, University Heart and Vascular Center, University Medical Center Hamburg Eppendorf, Hamburg, Germany.

The prevalence and economic burden of atrial fibrillation (AF) are predicted to more than double over the next few decades. In addition to anticoagulation and treatment of concomitant cardiovascular conditions, early and standardized rhythm control therapy reduces cardiovascular outcomes as compared with a rate control approach, favoring the restoration and maintenance of sinus rhythm safely. Current therapies for rhythm control of AF include anti-arrhythmic drugs (AAD) and catheter ablation (CA). Read More

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Is cardiac magnetic resonance imaging a game changer in re-ablation of atrial fibrillation?

Europace 2021 May 13. Epub 2021 May 13.

Département de Cardiologie, University Hospital Nancy, CHRU Nancy-Rue du Morvan- 54500 Vandoeuvre-les-Nancy, Nancy, France.

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Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine.

Nature 2021 May 12. Epub 2021 May 12.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.

Adaptive thermogenesis has attracted much attention because of its ability to increase systemic energy expenditure and to counter obesity and diabetes. Recent data have indicated that thermogenic fat cells use creatine to stimulate futile substrate cycling, dissipating chemical energy as heat. This model was based on the super-stoichiometric relationship between the amount of creatine added to mitochondria and the quantity of oxygen consumed. Read More

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Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to SLC7A11 inhibition.

Cancer Res 2021 May 12. Epub 2021 May 12.

Personalised Cancer Therapeutics, Cancer Division, The Kinghorn Cancer Centre, The Garvan Institute of Medical Research.

Cancer-Associated Fibroblasts (CAF) are major contributors to pancreatic ductal adenocarcinoma (PDAC) progression through pro-tumor signaling and the generation of fibrosis that creates a physical barrier to drugs. CAF inhibition is thus an ideal component of any therapeutic approach for PDAC. SLC7A11, a cystine transporter, has been identified as a potential therapeutic target in PDAC cells. Read More

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A Simple and Low-Cost Method for Fabrication of Polydimethylsiloxane Microfludic Chips.

J Nanosci Nanotechnol 2021 Nov;21(11):5635-5641

Key Laboratory of Computerized Numerical Control Equipment Reliability, Ministry of Education, School of Mechanical and Aerospace Engineering, Jilin University, Changchun 130012, China.

The conventional fabrication methods for enrichment microfluidic devices require cleanroom, which are costly and time-consuming. Developing a facile and low-cost method to fabricate microfluidic chips could stimulate the progress of the applications of those chips. Here, we present an easy method for fabrication of a complete PDMS (Polydimethylsiloxane) microfluidic chip used for ion and protein enrichment. Read More

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November 2021

Nanoparticles Determination by Laser Ablation Inductively Coupled Plasma Mass Spectrometry.

J Nanosci Nanotechnol 2021 Nov;21(11):5436-5442

CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, CAS-HKU Joint Laboratory of Metallomics on Health & Environment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.

Quantitatively studying the biodistribution and transformation of nanomaterials is of great importance for nanotoxicological evaluation. Recently, laser ablation inductively coupled plasma mass spectrometry has been employed to distinguish nanoparticles (NPs) with their dissolved ions in biological samples. The principle of the proposal is based on a hypothesis that the intact NPs sampled by laser ablation will generate discrete sharp pulses of signals in ICP-MS measurement, being totally different from the continuous, relatively lower signals generated by ions. Read More

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November 2021

Comparison between radiofrequency ablation combined with mifepristone and radiofrequency ablation for large uterine fibroids.

Int J Hyperthermia 2021 ;38(1):777-780

Department of Ultrasound, Beijing Chaoyang Hospital Capital Medical University, Beijing, PR China.

Objective: To evaluate the clinical outcomes of transvaginal ultrasound-guided (US-guided) radiofrequency ablation (RFA) combined with mifepristone for the treatment of large uterine fibroids.

Methods: Between June 2016 and December 2018, a total of 30 patients with symptomatic uterine fibroids (≥5cm) who underwent transvaginal US-guided RFA combined with mifepristone were included in this retrospective study. A matching cohort of 30 patients underwent transvaginal US-guided RFA without mifepristone as controls. Read More

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January 2021

Blocking FcγRIIB in Smooth Muscle Cells Reduces Hypertension.

Circ Res 2021 May 13. Epub 2021 May 13.

Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, CHINA.

Hypertension is a common chronic disease and its prevalence is increasing. Immunoglobulins (Igs) play crucial roles in adaptive immune response and have been implicated in the pathogenesis of hypertension. However, which Igs and receptors as well as underlying mechanisms participating in hypertension remains unknown. Read More

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Verapamil-sensitive idiopathic left ventricular tachycardia and concomitant atrioventricular nodal reentrant tachycardia.

J Electrocardiol 2021 Apr 21;67:7-10. Epub 2021 Apr 21.

Cardiology Department, Asklepeion General Hospital, Athens, Greece.

We describe the case of a young patient with runs of repetitive monomorphic left ventricular tachycardia. He was diagnosed with verapamil-sensitive, idiopathic left ventricular tachycardia (ILVT) and underwent an electrophysiological study, in which dual atrioventricular (AV) nodal physiology was evident, with an AV nodal reentrant tachycardia (AVNRT) being easily and reproducibly induced. Both the AVNRT and the ILVT were successfully ablated using high-density electroanatomical mapping and an open-irrigation catheter. Read More

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Efficient generation of isogenic primary human myeloid cells using CRISPR-Cas9 ribonucleoproteins.

Cell Rep 2021 May;35(6):109105

J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Parker Institute for Cancer Immunotherapy, San Francisco, CA 94129, USA; UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA. Electronic address:

Genome engineering of primary human cells with CRISPR-Cas9 has revolutionized experimental and therapeutic approaches to cell biology, but human myeloid-lineage cells have remained largely genetically intractable. We present a method for the delivery of CRISPR-Cas9 ribonucleoprotein (RNP) complexes by nucleofection directly into CD14 human monocytes purified from peripheral blood, leading to high rates of precise gene knockout. These cells can be efficiently differentiated into monocyte-derived macrophages or dendritic cells. Read More

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Brain Damage and Patterns of Neurovascular Disorder after Ionizing Irradiation. Complications in Radiotherapy and Radiation Combined Injury.

Radiat Res 2021 May 12. Epub 2021 May 12.

Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland.

Exposure to ionizing radiation, mechanical trauma, toxic chemicals or infections, or combinations thereof (i.e., combined injury) can induce organic injury to brain tissues, the structural disarrangement of interactive networks of neurovascular and glial cells, as well as on arrays of the paracrine and systemic destruction. Read More

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Spatially and size-resolved analysis of gold nanoparticles in rat spleen after intratracheal instillation by laser ablation-inductively coupled plasma-mass spectrometry.

Metallomics 2021 May 12. Epub 2021 May 12.

University of Münster, Institute of Inorganic and Analytical Chemistry, Corrensstraße 30, 48149 Münster, Germany.

In a dual approach, laser ablation-inductively coupled plasma-mass spectrometry was applied to investigate spleen samples of rats after intratracheal instillation of polyvinylpyrrolidone-coated gold nanoparticles. First, spatially resolved imaging analysis was deployed to investigate gold translocation from the lungs to the spleen and to investigate the distribution pattern of gold in the spleen parenchyma itself. Using the same instrumental setup, laser ablation-inductively coupled plasma-mass spectrometry in single particle mode was applied to determine the species of translocated gold. Read More

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Demise of nociceptive Schwann cells causes nerve retraction and pain hyperalgesia.

Pain 2021 Jun;162(6):1816-1827

Department of Medical Biochemistry and Biophysics, Division of Molecular Neurobiology, Karolinska Institutet, Stockholm, Sweden.

Abstract: Recent findings indicate that nociceptive nerves are not "free", but similar to touch and pressure sensitive nerves, terminate in an end-organ in mice. This sensory structure consists of the nociceptive nerves and specialized nociceptive Schwann cells forming a mesh-like organ in subepidermis with pain transduction initiated at both these cellular constituents. The intimate relation of nociceptive nerves with nociceptive Schwann cells in mice raises the question whether defects in nociceptive Schwann cells can by itself contribute to pain hyperalgesia, nerve retraction, and peripheral neuropathy. Read More

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The perils of dressings: a cautionary tale of ischaemia.

J Wound Care 2021 May;30(5):420-422

Queen Victoria Hospital, East Grinstead, UK.

A cohort of patients presented to Queen Victoria Hospital, UK, with iatrogenic toe ischaemia following application of a different, newly available post-procedure dressing with different properties to those usually used. This resulted in ischaemia with extensive skin and soft tissue damage, requiring debridement surgery and, in some cases, skin grafting. We aim to highlight the risk of morbidity from dressing application to the digits. Read More

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Long-term survival of 11 years with multidisciplinary therapy for hepatocellular carcinoma metastasis to the ovary and peritoneum: a case report.

Clin J Gastroenterol 2021 May 12. Epub 2021 May 12.

Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Niigata, Japan.

We herein report a rare case of HCC metastases to the ovary and peritoneum in a 61-year-old female patient who has achieved 11-year survival with multidisciplinary therapy. The patient was diagnosed with HCC during balloon angioplasty performed for Budd-Chiari syndrome in 1994 and underwent partial hepatectomy twice. Five years after the second hepatectomy, allochronic recurrence of a single nodule detected in S8 was treated by radiofrequency ablation, followed by percutaneous ethanol injection therapy and stereotactic body radiotherapy. Read More

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Vascular Sema3E-Plexin-D1 Signaling Reactivation Promotes Post-stroke Recovery through VEGF Downregulation in Mice.

Transl Stroke Res 2021 May 12. Epub 2021 May 12.

Neurovascular Biology Laboratory, Neurovascular Unit Research Group, Korea Brain Research Institute, Daegu, 41062, Republic of Korea.

Post-stroke vascular remodeling, including angiogenesis, facilitates functional recovery. Proper vascular repair is important for efficient post-stroke recovery; however, the underlying mechanisms coordinating the diverse signaling pathways involved in vascular remodeling remain largely unknown. Recently, axon guidance molecules were revealed as key players in injured vessel remodeling. Read More

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Response factors associated with electrocautery treatment of intra-anal high-grade squamous intraepithelial lesions in a population of HIV-positive men who have sex with men.

Int J STD AIDS 2021 May 12:9564624211017005. Epub 2021 May 12.

Department of Infectious Diseases, 16493Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain.

Background: Ablative treatment of anal high-grade squamous intraepithelial lesions (HSIL) reduces the risk of progression to anal squamous cell carcinoma.

Objectives: To identify factors that influence the response to treatment of anal HSIL by electrocautery ablation (ECA) in a population of HIV-positive men who have sex with men (MSM).

Design: Retrospective study of ECA treatment response in a prospectively followed anal dysplasia cohort. Read More

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Effects of acupuncture on pain and levels of IL-17 and IL-23 in the treatment of non-thermal endovenous ablation: A randomized clinical trial.

Vascular 2021 May 12:17085381211013980. Epub 2021 May 12.

Department of Medical Pharmacology, Faculty of Medicine, Sivas Cumhuriyet University, Sivas, Turkey.

Objectives: Acupuncture is one of the oldest therapeutic interventions in the world for the treatment of pain, musculoskeletal diseases, and inflammation. This study aimed to investigate the effect of acupuncture on pain and IL-17 and IL-23 levels in the treatment of endovenous ablation.

Methods: The study was a randomized controlled trial. Read More

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Biosense Webster's QDOT Micro™ radiofrequency ablation catheter.

Future Cardiol 2021 May 12. Epub 2021 May 12.

Department of Cardiology, Sint-Jan Hospital, Bruges, Belgium.

The QDOT Micro™ catheter (Biosense Webster, Inc., CA, USA) is a new radiofrequency ablation catheter based on the SmartTouch SF™ (Biosense Webster, Inc.). Read More

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Prostate minimally invasive procedures: complications and normal vs. abnormal findings on multiparametric magnetic resonance imaging (mpMRI).

Abdom Radiol (NY) 2021 May 11. Epub 2021 May 11.

Department of Radiological Sciences, University of California, Irvine, Orange, CA, 92868-3201, USA.

Minimally invasive alternatives to traditional prostate surgery are increasingly utilized to treat benign prostatic hyperplasia and localized prostate cancer in select patients. Advantages of these treatments over prostatectomy include lower risk of complication, shorter length of hospital stay, and a more favorable safety profile. Multiparametric magnetic resonance imaging (mpMRI) has become a widely accepted imaging modality for evaluation of the prostate gland and provides both anatomical and functional information. Read More

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Results from a real-time dosimetry study during left atrial ablations performed with ultra-low dose radiation settings.

Herzschrittmacherther Elektrophysiol 2021 May 11. Epub 2021 May 11.

Department of Cardiology, Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 3, 12203, Berlin, Germany.

Background: Three-dimensional mapping systems and the use of ultra-low dose radiation protocols have supported minimization of radiation dose during left atrial ablation procedures. By using optimal shielding, scattered radiation reaching the operator can be further reduced. This prospective study was designed to determine the remaining operator radiation exposure during left atrial catheter ablations using real-time dosimetry. Read More

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