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Circ_0017956 promotes the proliferation and metastasis of non-small cell lung cancer through regulating miR-515-5p/ITGB8 axis.

Authors:
Na Li Dan Zhu

Cell Cycle 2021 May 4:1-13. Epub 2021 May 4.

Department of Respiratory, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.

Circular RNAs (circRNAs) have been reported to exert vital roles in the tumorigenesis of non-small cell lung cancer (NSCLC). The study aimed to probe the function of circ_0017956 in NSCLC development. The expression of circ_0017956, microRNA (miR)-515-5p and integrin subunit beta 8 (ITGB8) was gauged by quantitative real-time polymerase chain reaction (qRT-PCR) or western blot. Read More

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Bias and blindsight: A reply to Michel and Lau (2021).

Authors:
Ian Phillips

Psychol Rev 2021 Apr;128(3):592-595

William H. Miller III Department of Philosophy, Johns Hopkins University.

According to the textbooks, blindsight is a neuropsychological condition characterized by preserved capacities for voluntary visual discrimination unaccompanied by visual awareness. So construed, blindsight precipitated a revolution in theorizing consciousness. In Phillips (Psychological Review, 2021), I argued that the textbooks are wrong and the revolution ill-founded. Read More

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Diagnosability of Synthetic Retinal Fundus Images for Plus Disease Detection in Retinopathy of Prematurity.

AMIA Annu Symp Proc 2020 25;2020:329-337. Epub 2021 Jan 25.

Medical Informatics & Clinical Epidemiology.

Advances in generative adversarial networks have allowed for engineering of highly-realistic images. Many studies have applied these techniques to medical images. However, evaluation of generated medical images often relies upon image quality and reconstruction metrics, and subjective evaluation by laypersons. Read More

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January 2021

Candidate Molecular Biomarkers for the Non- Invasive Detection of Colorectal Cancer using Gene Expression Profiling.

Iran J Pathol 2021 2;16(2):205-214. Epub 2021 Mar 2.

Gastrointestinal and Liver Disease Research Center (GILDRC), Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.

Background & Objective: olorectal Cancer (CRC) is the third most common cancer after prostate (breast in women) and lung cancer; it is also the third cause of cancer deaths reported in both men and women in 2020. Currently, the most commonly used diagnostic tools for CRC are colonoscopy, serological methods, and other imaging techniques. Despite the benefits and abilities of these methods, each of them has disadvantages that reduce its functionality and acceptance. Read More

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Connecting the Dots: a cluster-randomized clinical trial integrating standardized autism spectrum disorders screening, high-quality treatment, and long-term outcomes.

Trials 2021 May 2;22(1):319. Epub 2021 May 2.

AJ Drexel Autism Institute, Drexel University, 3020 Market Street, Philadelphia, PA, 19104, USA.

Background: Autism spectrum disorder (ASD) affects one in 54 children in the United States of America, and supporting people with ASD across the lifespan presents challenges that impact individuals, families, and communities and can be quite costly. The American Academy of Pediatrics has issued recommendations for routine ASD screening at 18 and 24 months, but some research suggests that few pediatricians perform high-fidelity, standardized screening universally. Furthermore, the United States Preventive Services Task Force (USPSTF) found insufficient evidence to recommend for or against universal ASD screening. Read More

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An Efficient Anomaly Recognition Framework Using an Attention Residual LSTM in Surveillance Videos.

Sensors (Basel) 2021 Apr 16;21(8). Epub 2021 Apr 16.

Sejong University, Seoul 143-747, Korea.

Video anomaly recognition in smart cities is an important computer vision task that plays a vital role in smart surveillance and public safety but is challenging due to its diverse, complex, and infrequent occurrence in real-time surveillance environments. Various deep learning models use significant amounts of training data without generalization abilities and with huge time complexity. To overcome these problems, in the current work, we present an efficient light-weight convolutional neural network (CNN)-based anomaly recognition framework that is functional in a surveillance environment with reduced time complexity. Read More

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The Role and Impact of Deep Learning Methods in Computer-Aided Diagnosis Using Gastrointestinal Endoscopy.

Diagnostics (Basel) 2021 Apr 14;11(4). Epub 2021 Apr 14.

School of Computer Science, University of Nottingham, Nottingham NG7 2RD, UK.

At present, the application of artificial intelligence (AI) based on deep learning in the medical field has become more extensive and suitable for clinical practice compared with traditional machine learning. The application of traditional machine learning approaches to clinical practice is very challenging because medical data are usually uncharacteristic. However, deep learning methods with self-learning abilities can effectively make use of excellent computing abilities to learn intricate and abstract features. Read More

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Protective Football Headgear and Peripheral Visuomotor Ability in NCAA Football Athletes: The Role of Facemasks and Visors.

J Funct Morphol Kinesiol 2021 Apr 8;6(2). Epub 2021 Apr 8.

Department of Kinesiology, Samford University, Birmingham, AL 35229, USA.

The purpose of this investigation was to determine the effects of varying facemask reinforcement and visor tint on peripheral visuomotor abilities in collegiate football players. Division I NCAA football players ( = 14) completed two peripheral visuomotor experiments: (1) Varying facemask reinforcement, (2) Varying visor tinting. In experiment 1, participants were tested under the following conditions: baseline (no helmet; BL), helmet + light (HL), helmet + medium (HM), helmet + heavy (HH), and helmet + extra heavy (HXH) reinforced facemasks. Read More

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Network ecology in dynamic landscapes.

Proc Biol Sci 2021 Apr 28;288(1949):20201889. Epub 2021 Apr 28.

Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada.

Network ecology is an emerging field that allows researchers to conceptualize and analyse ecological networks and their dynamics. Here, we focus on the dynamics of ecological networks in response to environmental changes. Specifically, we formalize how network topologies constrain the dynamics of ecological systems into a unifying framework in network ecology that we refer to as the 'ecological network dynamics framework'. Read More

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Microfluidic particle accumulation for visual quantitation of copper ions.

Mikrochim Acta 2021 Apr 27;188(5):176. Epub 2021 Apr 27.

Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, Hong Kong.

A portable biosensor has been developed based on microfluidic particle accumulation for visual quantification of copper ions. A copper-dependent DNAzyme is used to connect magnetic microparticles (MMPs) and polystyrene microparticles (PMPs), forming "MMPs-DNAzyme-PMPs." When copper ions are present, the DNAzyme is cleaved, allowing free PMPs to be released from the MMPs-DNAzyme-PMP complex. Read More

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The Measurement of Everyday Cognition (ECog): Revisions and Updates.

Alzheimer Dis Assoc Disord 2021 Apr 26. Epub 2021 Apr 26.

Departments of Neurology Public Health, University of California, Davis, Davis, CA Eli Lilly and Company, Indianapolis, IN.

Introduction: The Everyday Cognition scale (ECog), a measure of everyday functioning developed in 2008, is sensitive to early detection and progression of neurodegenerative disease. The goal was to update ECog item content to ensure relevancy to contemporary older adults from diverse backgrounds.

Methods: Participants included 44 culturally diverse older adults (18 with normal cognition, 11 with mild cognitive impairment) and their study partners. Read More

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A sulfamethoxazole molecularly imprinted two-dimensional photonic crystal hydrogel sensor.

Soft Matter 2021 Apr 26. Epub 2021 Apr 26.

School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi'an 710129, P. R. China.

In this paper, a molecularly imprinted two-dimensional photonic crystal hydrogel sensor (SMZ-MIPCH) for the sensitive and label-free recognition of sulfamethoxazole (SMZ) was prepared. The SMZ-MIPCH sensor response performance was investigated via measuring the diameter of the Debye ring (D). When the SMZ-MIPCH sensor recognized SMZ, the diameter of the Debye ring gradually decreased and the particle spacing (d) of the photonic crystals gradually increased. Read More

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Long Non-coding RNA LINC02474 Affects Metastasis and Apoptosis of Colorectal Cancer by Inhibiting the Expression of GZMB.

Front Oncol 2021 9;11:651796. Epub 2021 Apr 9.

Department of Clinical Laboratory, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Background: Colorectal cancer (CRC) is one of the most frequently diagnosed malignancies. Metastasis is the main event that impedes the therapeutic effect on CRC, and its underlying mechanisms remain largely unclear. LINC02474 is a novel long noncoding RNA (lncRNA) associated with metastasis of CRC, while little is known about how LINC02474 regulates these malignant characteristics. Read More

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Multilevel Pathways of Colorectal Cancer Screening Among Low-Income Vietnamese Americans: A Structural Equation Modeling Analysis.

Cancer Control 2021 Jan-Dec;28:10732748211011077

Center for Asian Health, 12314Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.

Background: Colorectal cancer (CRC) disproportionately affects Vietnamese Americans, especially those with low income and were born outside of the United States. CRC screening tests are crucial for prevention and early detection. Despite the availability of noninvasive, simple-to-conduct tests, CRC screening rates in Asian Americans, particularly Vietnamese Americans, remain suboptimal. Read More

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A fluorescence aptasensor for the sensitive detection of T-2 toxin based on FRET by adjusting the surface electric potentials of UCNPs and MIL-101.

Anal Chim Acta 2021 May 26;1160:338450. Epub 2021 Mar 26.

Tianjin Key Laboratory of Risk Assessment and Control Technology for Environment and Food Safety, Tianjin Institute of Environmental and Operational Medicine, Tianjin, 300050, PR China. Electronic address:

T-2 toxin is a class A trichothecene mycotoxin produced by Fusarium, which exhibits genotoxic, cytotoxic, and immunotoxic effects in animals and humans. In this study, we developed an aptasensor for the sensitive detection of T-2 toxin, which was based on fluorescence resonance energy transfer (FRET), and acted by adjusting the electric potential on the surface of upconversion nanoparticles (UCNPs) and MIL-101(Cr). In addition, it combined the excellent spectral properties of UCNPs with the good adsorption quenching abilities of metal organic frameworks (MOFs). Read More

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Ratiometric Fluorescent DNA Nanostructure for Mitochondrial ATP Imaging in Living Cells Based on Hybridization Chain Reaction.

Anal Chem 2021 May 22;93(17):6715-6722. Epub 2021 Apr 22.

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha 410082, China.

For intracellular molecular detection, the appropriate probes should include the abilities to enter target cells noninvasively, target specific sites, and then respond to the analytes reliably. Herein, a ratiometric fluorescent DNA nanostructure (RFDN) was designed for mitochondrial adenosine triphosphate (ATP) imaging in living cells. The DNA nanostructure was constructed by continuous hybridization of two hairpin DNA strands (HS1-Cy3 and HS2-Cy5) under the initiation of the trigger. Read More

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Perceptions Among Medical Staff in Community Health Centres of Coping Capacity Regarding Infectious Disease Epidemics: A Cross-Sectional Study in Shanghai, China.

Int J Gen Med 2021 13;14:1251-1261. Epub 2021 Apr 13.

Department of General Practice, Yangpu Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.

Background: With the increasing risk of infectious disease outbreaks around the world, the role of community health centres (CHCs) in the prevention and control of epidemics has become increasingly prominent. This study aimed to examine the capacities, vulnerabilities, and obstacles related to coping with infectious disease epidemics in Chinese CHCs.

Methods: A cross-sectional study was conducted in Shanghai CHCs. Read More

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Artificial Intelligence-based methods in head and neck cancer diagnosis: an overview.

Br J Cancer 2021 Apr 19. Epub 2021 Apr 19.

Unit of Oral & Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, UK.

Background: This paper reviews recent literature employing Artificial Intelligence/Machine Learning (AI/ML) methods for diagnostic evaluation of head and neck cancers (HNC) using automated image analysis.

Methods: Electronic database searches using MEDLINE via OVID, EMBASE and Google Scholar were conducted to retrieve articles using AI/ML for diagnostic evaluation of HNC (2009-2020). No restrictions were placed on the AI/ML method or imaging modality used. Read More

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Detecting Progression in Patients with Different Clinical Presentations of Primary Open-angle Glaucoma.

J Glaucoma 2021 Apr 12. Epub 2021 Apr 12.

Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, AL 35233, USA Computational Optometry, Atarfe, Spain.

Prcis: Glaucoma progression was more frequently identified by assessing retinal fiber layer thickness than by monitoring visual field loss for different baseline classifications in primary open-angle glaucoma.

Purpose: To compare the detection of glaucoma progression by retinal nerve fiber layer thickness (RNFLT) and visual field (VF) assessments for different baseline classifications of primary open-angle glaucoma (POAG).

Methods: This study included 194 eyes from 194 patients with a minimum of 9 follow-up visits selected from the Diagnostic Innovation in Glaucoma Study and the African Descent and Glaucoma Evaluation Study. Read More

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Iodide/metal-organic frameworks (MOF) -mediated signal amplification strategy for the colorimetric detection of HO, CrO and HS.

Anal Chim Acta 2021 May 12;1159:338378. Epub 2021 Mar 12.

College of Chemistry and Chemical Engineering, Yunnan Normal University, Yunnan, Kunming, 650092, PR China. Electronic address:

The analytical methods based on colorimetric detection of various analytes have attracted intensive interest. However, most of them display relatively low sensitivity. Herein, a novel colorimetric strategy based on iodide/metal-organic frameworks (MOF)-mediated amplification was developed for low-cost, naked-eye detection and quantification of HO,CrO, and HS. Read More

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Surface-Radical Mobility Test by Self-Sorted Recombination: Symmetrical Product upon Recombination (SPR).

J Phys Chem B 2021 Apr 15;125(16):4212-4220. Epub 2021 Apr 15.

Department of Chemistry, Brooklyn College, 2900 Bedford Avenue, Brooklyn, New York 11210, United States.

We describe here a study of the mobility of the alkoxy radical on a surface by detection of its recombination product. A novel method called symmetrical product recombination (SRP) uses an unsymmetrical peroxide that upon sensitized homolysis recombines to a symmetrical product [R'OOR → R'O↑ + OR → ROOR]. This allows for self-sorting of the radical to enhance the recombination path to a symmetrical product, which has been used to deduce surface migratory aptitude. Read More

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Mechanism Across Scales: A Holistic Modeling Framework Integrating Laboratory and Field Studies for Microbial Ecology.

Front Microbiol 2021 24;12:642422. Epub 2021 Mar 24.

Division of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA, United States.

Over the last century, leaps in technology for imaging, sampling, detection, high-throughput sequencing, and -omics analyses have revolutionized microbial ecology to enable rapid acquisition of extensive datasets for microbial communities across the ever-increasing temporal and spatial scales. The present challenge is capitalizing on our enhanced abilities of observation and integrating diverse data types from different scales, resolutions, and disciplines to reach a causal and mechanistic understanding of how microbial communities transform and respond to perturbations in the environment. This type of causal and mechanistic understanding will make predictions of microbial community behavior more robust and actionable in addressing microbially mediated global problems. Read More

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Glucose metabolism in the right middle temporal gyrus could be a potential biomarker for subjective cognitive decline: a study of a Han population.

Alzheimers Res Ther 2021 04 7;13(1):74. Epub 2021 Apr 7.

Key laboratory of Specialty Fiber Optics and Optical Access Networks, Joint International Research Laboratory of Specialty Fiber Optics and Advanced Communication, School of Information and Communication Engineering, Shanghai University, Shanghai, China.

Introduction: Subjective cognitive decline (SCD) represents a cognitively normal state but at an increased risk for developing Alzheimer's disease (AD). Recognizing the glucose metabolic biomarkers of SCD could facilitate the location of areas with metabolic changes at an ultra-early stage. The objective of this study was to explore glucose metabolic biomarkers of SCD at the region of interest (ROI) level. Read More

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Transglycosylation abilities of β-d-galactosidases from GH family 2.

3 Biotech 2021 Apr 15;11(4):168. Epub 2021 Mar 15.

Department of Biochemistry and Microbiology, University of Chemistry and Technology, Prague, Technická 5, Prague 6, 166 28 Czech Republic.

The ability to predict the transglycosylation activity of glycosidases by in silico analysis was investigated. The transglycosylation abilities of 7 different β-d-galactosidases from GH family 2 were tested experimentally using 7 different acceptors and -nitrophenyl-β-d-galactopyranoside as a donor of galactosyl moiety. Similar transglycosylation abilities were confirmed for all enzymes originating from bacteria belonging to , which were able to use all tested acceptor molecules. Read More

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DailyCog: A Real-World Functional Cognitive Mobile Application for Evaluating Mild Cognitive Impairment (MCI) in Parkinson's Disease.

Sensors (Basel) 2021 Mar 4;21(5). Epub 2021 Mar 4.

Movement Disorders Institute, Sheba Medical Center, Ramat-Gan 5262000, Israel.

Parkinson's disease (PD) is the second most common progressive neurodegenerative disorder affecting patient functioning and quality of life. Aside from the motor symptoms of PD, cognitive impairment may occur at early stages of PD and has a substantial impact on patient emotional and physical health. Detecting these early signs through actual daily functioning while the patient is still functionally independent is challenging. Read More

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Does DDI-Predictor Help Pharmacists to Detect Drug-Drug Interactions and Resolve Medication Issues More Effectively?

Metabolites 2021 Mar 17;11(3). Epub 2021 Mar 17.

Institut de Pharmacie, CHU Lille, F-59000 Lille, France.

The characterization of drug-drug interactions (DDIs) may require the use of several different tools, such as the thesaurus issued by our national health agency (i.e., ANSM), the metabolic pathways table from the Geneva University Hospital (GUH), and DDI-Predictor (DDI-P). Read More

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Characteristics of Physical Exercise Programs for Older Adults in Latin America: A Systematic Review of Randomized Controlled Trials.

Int J Environ Res Public Health 2021 03 10;18(6). Epub 2021 Mar 10.

Escuela de Kinesiología, Facultad de Salud, Universidad Santo Tomás, Los Ángeles 4440000, Chile.

Aim: To characterize physical exercise programs for older adults in Latin America.

Methods: This review was conducted in accordance with the PRISMA statement. A search for randomized controlled trials (RCTs) published between the years 2015 and 2020 was performed in the Scopus, MedLine and SciELO databases. Read More

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Effects of medical resource capacities and intensities of public mitigation measures on outcomes of COVID-19 outbreaks.

BMC Public Health 2021 03 29;21(1):605. Epub 2021 Mar 29.

Department of Applied Mathematics, Xi'an Jiaotong University, Xi'an, 710049, P.R. China.

Background: The COVID-19 pandemic is complex and is developing in different ways according to the country involved.

Methods: To identify the key parameters or processes that have the greatest effects on the pandemic and reveal the different progressions of epidemics in different countries, we quantified enhanced control measures and the dynamics of the production and provision of medical resources. We then nested these within a COVID-19 epidemic transmission model, which is parameterized by multi-source data. Read More

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Evaluation of the role of staphylococci in the pathomechanism of conjunctivitis.

Int Ophthalmol 2021 Mar 28. Epub 2021 Mar 28.

Chair and Department of Medical Microbiology, Medical University of Lublin, Lublin, Poland.

Purpose: Determination of the association between ica genes and phenotypic biofilm formation in staphylococcal isolates involved in conjunctivitis, their antibiotic resistance as well as detection of selected virulence characteristics: adhesion to epithelial cells and in vitro cytotoxicity.

Methods: The study included 26 Staphylococcus aureus (SA) and 26 Staphylococcus epidermidis (SE) isolates. The presence of icaAD genes and ica operon was determined by the PCR assay. Read More

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