Eur J Vasc Endovasc Surg 2021 May 1. Epub 2021 May 1.
Department of Cardiac, Thoracic and Vascular Surgery, Odense University Hospital, Odense, Denmark; Vascular Research Unit, Regional Hospital Central Denmark, Viborg, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Objective: Inactivation of matrix Gla protein (MGP), using vitamin K antagonists or vitamin K deficiency results in increased vascular calcification, which has been associated with increased risk of symptomatic or ruptured abdominal aortic aneurysm (AAA). Insufficient activation of MGP leads to increased levels of undercarboxylated forms of MGP, measured as a dephosphorylated, undercarboxylated MGP (dp-ucMGP) in plasma. This study aimed to investigate whether the level of inactivated MGP influenced the risk of having an AAA, the risk of AAA progression, and overall mortality. Read More