Eur J Pharmacol 2019 Apr 25;848:70-79. Epub 2019 Jan 25.
Department of Physiology and Pharmacology, Des Moines University Osteopathic Medical Center, Ryan Hall 258, 3200 Grand Avenue, Des Moines, IA 50312, United States. Electronic address:
Cardiovascular functions are mediated by multiple 7-pass transmembrane receptors whose activation promotes contraction or relaxation of the tissues. The α adrenoceptor type 1A plays important roles in the control of vascular tone and myocardial contractility via Ca-dependent actions. Here, using novel FRET-based biosensors, we identified a novel Ca-dependent interaction between calmodulin (CaM) and the human α adrenoceptor at the juxtamembranous region of its 4th submembrane domain (SMD4, a. Read More