4,429 results match your criteria Zygomycosis


A Rhinofacial Fungal Infection Presenting as an Intranasal Tumour.

Sultan Qaboos Univ Med J 2018 Nov 28;18(4):e549-e552. Epub 2019 Mar 28.

Center of Advanced Research in Medical Mycology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

Conidiobolomycosis is a rare fungal infection that affects adults in tropical regions. We report a 42-year-old male patient who was referred to the Sulaiman Al Habib Hospital, Dubai, United Arab Emirates (UAE), in 2013 with excessive nasal bleeding and a suspected nasal tumour. He reported having briefly visited central India nine months previously. Read More

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https://journals.squ.edu.om/index.php/squmj/article/view/300
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http://dx.doi.org/10.18295/squmj.2018.18.04.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443265PMC
November 2018
2 Reads

Invasive fungal consecutive infections in a patient with acute myeloid leukaemia.

Niger J Clin Pract 2019 Apr;22(4):582-584

Department of Infectious Diseases, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

A woman with AML who became febrile and neutropenic after chemotherapy. At the first, Aspergillus was isolated from a sinus biopsy. After 4 weeks, while she was taking voriconazole, another episode of fever combined with dry coughs was detected. Read More

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http://dx.doi.org/10.4103/njcp.njcp_359_17DOI Listing
April 2019
2 Reads

Sources of microbial oils with emphasis to Mortierella (Umbelopsis) isabellina fungus.

World J Microbiol Biotechnol 2019 Mar 28;35(4):63. Epub 2019 Mar 28.

Unit of Microbiology, Department of Biology, Division of Genetics, Cell Biology and Development, University of Patras, 26504, Patras, Greece.

The last years a constantly rising number of publications have appeared in the literature in relation to the production of oils and fats deriving from microbial sources (the "single cell oils"-SCOs). SCOs can be used as precursors for the synthesis of lipid-based biofuels or employed as substitutes of expensive oils rarely found in the plant or animal kingdom. In the present review-article, aspects concerning SCOs (economics, biochemistry, substrates, technology, scale-up), with emphasis on the potential of Mortierella isabellina were presented. Read More

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http://dx.doi.org/10.1007/s11274-019-2631-zDOI Listing

Gastrointestinal pythiosis with concurrent presumptive gastrointestinal basidiobolomycosis in a Boxer dog.

Vet Clin Pathol 2019 Mar 21;48(1):83-88. Epub 2019 Mar 21.

Departments of Small Animal Clinical Sciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas.

A 2-year-old female spayed Boxer dog was presented for a 1-month history of progressive hemorrhagic diarrhea with tenesmus and weight loss despite trial courses of antibiotics and diet change. Abdominal ultrasound revealed severe, focal thickening, and loss of normal architecture of the colonic wall with abdominal lymphadenomegaly. Dry-mount fecal cytology, performed on several consecutive days, consistently revealed numerous, round, 16-20 μm structures with basophilic, granular content, and a thin cell wall. Read More

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http://dx.doi.org/10.1111/vcp.12720DOI Listing
March 2019
1.273 Impact Factor

Fatal renal mucormycosis with Apophysomyces elegans in an apparently healthy male.

Aging Male 2019 Mar 16:1-4. Epub 2019 Mar 16.

a Department of Laboratory Medicine and Pathology , Hamad General Hospital , Doha , Qatar.

Mucor is an angioinvasive fungus that was reported mainly in immunocompromised patients. It usually presents as rhino-orbital, pulmonary, gastrointestinal, and disseminated disease. Isolated renal mucormycosis is an extremely rare infection in immunocompetent patients and is associated with high fatality rate. Read More

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http://dx.doi.org/10.1080/13685538.2019.1586871DOI Listing
March 2019
2 Reads

Posaconazole salvage therapy: The Posifi study.

Mycoses 2019 Mar 12. Epub 2019 Mar 12.

Infectious Diseases Department, Hospital Ramón y Cajal, IRYCIS (Instituto Ramón y Cajal de Investigación Sanitaria), Universidad de Alcalá, Madrid, Spain.

Background: Posaconazole (PCZ) is used mainly for the prevention of invasive fungal infection (IFI).

Methods: A multicentre retrospective, investigational study using a non-randomized, single-arm design carried out in six tertiary hospitals in Spain to evaluate the use of PCZ in different forms of administration in the (non-prophylactic) treatment of IFI.

Results: Over an eight-year-period, 67 patients were included in this study. Read More

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http://dx.doi.org/10.1111/myc.12911DOI Listing
March 2019
10 Reads

An instance of excellent response of subcutaneous zygomycosis to itraconazole monotherapy.

Med Mycol Case Rep 2019 Jun 14;24:13-17. Epub 2019 Feb 14.

Department of Pathology, All India Institute of Medical Sciences, Raipur, 492099, India.

Subcutaneous zygomycosis is a rare fungal infection caused by . This entity is usually endemic in South India and only limited numbers of cases have been reported from central India. We report a case of 4-year-old male child from Chhattisgarh, who presented with a painless, non-tender, large, subcutaneous swelling of 4 months duration on the right upper arm, which was initially misdiagnosed as benign spindle cell tumor and advised surgical resection. Read More

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http://dx.doi.org/10.1016/j.mmcr.2019.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395828PMC
June 2019
1 Read

Pathogenicity patterns of mucormycosis: epidemiology, interaction with immune cells and virulence factors.

Med Mycol 2019 Apr;57(Supplement_2):S245-S256

Jena Microbial Resource Collection, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Adolf-Reichwein-Strasse 23, 07745 Jena, Germany.

Fungi of the basal lineage order Mucorales are able to cause infections in animals and humans. Mucormycosis is a well-known, life-threatening disease especially in patients with a compromised immune system. The rate of mortality and morbidity caused by mucormycosis has increased rapidly during the last decades, especially in developing countries. Read More

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http://dx.doi.org/10.1093/mmy/myz011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394756PMC
April 2019
3 Reads

Contrasts between mucormycosis and aspergillosis in oncohematological patients.

Med Mycol 2019 Apr;57(Supplement_2):S138-S144

I.P.Pavlov First Saint Petersburg State Medical University, 6-8 L'va Tolstogo str., Saint Petersburg, Russian Federation, 197022.

In retrospective multicenter study from years 2007-2017, we evaluated 59 oncohematological patients with mucormycosis and 541 with invasive aspergillosis (IA). Mucormycosis developed more often in children and adolescents (P = .001), as well as after the emergence of graft versus host disease (P = . Read More

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http://dx.doi.org/10.1093/mmy/myy116DOI Listing
April 2019
6 Reads

Severe facial necrosis in a type 1 diabetic patient secondary to mucormycosis masquerading as an internal maxillary artery occlusion: a case report.

BMC Infect Dis 2019 Feb 22;19(1):184. Epub 2019 Feb 22.

Alberta Health Services, Calgary, Canada.

Background: Mucormycosis is a group of rare but life threatening angioinvasive infections caused by fungi of the order Mucorales that often occurs in immunocompromised patients and individuals with poorly controlled diabetes. Rhinocerebral mucormycosis can mimic sinusitis but can rapidly progress to deeper disease and cause facial necrosis. Facial vascular thrombosis is a rare complication of mucormycosis and can confound diagnosis of the disease. Read More

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http://dx.doi.org/10.1186/s12879-019-3822-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387511PMC
February 2019
3 Reads

Pulmonary Mucormycosis (Zygomycosis) Presenting as an Infective Exacerbation of Chronic Obstructive Pulmonary Disease.

Eur J Case Rep Intern Med 2018 27;5(12):000995. Epub 2018 Dec 27.

Department of Respiratory Medicine, Nicosia General Hospital, Cyprus.

Mucormycosis is a life-threatening fungal infection whose incidence has been rising recently, mainly due to the increasing use of immunosuppressive and corticosteroid treatment. In previous decades, mucormycosis was associated with a very poor prognosis as mortality was approximately 100%. Mortality rates reported in recent literature have only slightly improved despite the availability of targeted therapy with amphotericin B. Read More

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http://dx.doi.org/10.12890/2018_000995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346968PMC
December 2018
7 Reads

Cost-effectiveness analysis of isavuconazole versus voriconazole for the treatment of patients with possible invasive aspergillosis in Sweden.

BMC Infect Dis 2019 Feb 11;19(1):134. Epub 2019 Feb 11.

Department of Medical Sciences, Infectious Diseases, Uppsala University, Uppsala, Sweden.

Background: Voriconazole is well established as standard treatment for invasive aspergillosis (IA). In 2017, isavuconazole, a new antifungal from the azole class, with a broader pathogen spectrum, was introduced in Sweden. A model has therefore been developed to compare the cost-effectiveness of isavuconazole and voriconazole in the treatment of possible IA in adults in Sweden. Read More

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http://dx.doi.org/10.1186/s12879-019-3683-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371439PMC
February 2019
1 Read

Broad antifungal resistance mediated by RNAi-dependent epimutation in the basal human fungal pathogen Mucor circinelloides.

PLoS Genet 2019 02 11;15(2):e1007957. Epub 2019 Feb 11.

Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, North Carolina, United States of America.

Mucormycosis-an emergent, deadly fungal infection-is difficult to treat, in part because the causative species demonstrate broad clinical antifungal resistance. However, the mechanisms underlying drug resistance in these infections remain poorly understood. Our previous work demonstrated that one major agent of mucormycosis, Mucor circinelloides, can develop resistance to the antifungal agents FK506 and rapamycin through a novel, transient RNA interference-dependent mechanism known as epimutation. Read More

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http://dx.plos.org/10.1371/journal.pgen.1007957
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http://dx.doi.org/10.1371/journal.pgen.1007957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386414PMC
February 2019
3 Reads

Thrives inside the Phagosome through an Atf-Mediated Germination Pathway.

MBio 2019 02 5;10(1). Epub 2019 Feb 5.

Departamento de Genética y Microbiología, Universidad de Murcia, Murcia, Spain

Mucormycosis is an emerging fungal infection that is often lethal due to the ineffectiveness of current therapies. Here, we have studied the first stage of this infection-the germination of spores inside phagocytic cells-from an integrated transcriptomic and functional perspective. A relevant fungal gene network is remodeled in response to phagocytosis, being enriched in crucial functions to survive and germinate inside the phagosome, such as nutritional adaptation and response to oxidative stress. Read More

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http://mbio.asm.org/lookup/doi/10.1128/mBio.02765-18
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http://dx.doi.org/10.1128/mBio.02765-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428757PMC
February 2019
9 Reads

Gastrointestinal mucormycosis in a child with acute lymphoblastic leukemia: An uncommon but ominous complication.

Indian J Cancer 2018 Jul-Sep;55(3):304-305

Department of Medical Oncology, Cancer Institute (WIA), Chennai, Tamil Nadu, India.

Invasive fungal infections constitute a major cause of morbidity and mortality in children undergoing therapy for hematological malignancies. We report a 1-year-old boy who was receiving chemotherapy for acute lymphoblastic leukemia. His clinical course was complicated by a clinical syndrome consistent with neutropenic enterocolitis to which he succumbed. Read More

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http://dx.doi.org/10.4103/ijc.IJC_260_18DOI Listing
January 2019
4 Reads

Neonatal Acute Liver Failure Associated with Angioinvasive Hepatic Zygomycosis.

Fetal Pediatr Pathol 2018 Dec 31:1-8. Epub 2018 Dec 31.

a Department of Histopathology , Post Graduate Institute of Medical Education and Research , Chandigarh , India.

Background: Neonatal acute liver failure (NALF) is often a fatal condition. Zygomycosis is a fungal infection that is often fatal in both adults and infants. Only a few cases of hepatic zygomycosis are reported in the literature and they are invariably associated with immunosuppression. Read More

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http://dx.doi.org/10.1080/15513815.2018.1556368DOI Listing
December 2018
6 Reads
0.398 Impact Factor

Inpatient Mortality After Endoscopic Sinus Surgery for Invasive Fungal Rhinosinusitis.

Ann Otol Rhinol Laryngol 2019 Apr 25;128(4):300-308. Epub 2018 Dec 25.

2 Division of Otolaryngology - Head and Neck Surgery, University of California, San Diego, San Diego, CA, USA.

Objectives:: Invasive fungal rhinosinusitis is a rare, life-threatening condition that affects the paranasal sinuses. The standard of care after diagnosis includes surgical debridement and aggressive medical management. Despite treatment, mortality remains unacceptably high. Read More

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http://dx.doi.org/10.1177/0003489418820871DOI Listing
April 2019
3 Reads

Rhinocerebral mucormycosis after functional endoscopic sinus surgery: A case report.

Medicine (Baltimore) 2018 Dec;97(51):e13290

Department of Otolaryngology-Head and Neck Surgery.

Rationale: Mucormycosis is a rare fungal infection which mainly develops in compromised hosts and the associated mortality rate is high.

Patient Concerns: We report a case of mucormycosis in a 59-year-old woman following routine endoscopic sinus surgery. The patient had a history of diabetes mellitus (DM) and bronchial asthma. Read More

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http://dx.doi.org/10.1097/MD.0000000000013290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319933PMC
December 2018
17 Reads

Mycotic Rhinitis and Sinusitis in Florida Horses.

Vet Pathol 2018 Dec 17:300985818817046. Epub 2018 Dec 17.

1 Department of Comparative, Diagnostic and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.

Rhinitis and sinusitis caused by fungal pathogens were studied in biopsy samples submitted from 52 horses distributed throughout subtropical and tropical regions of Florida. Methods included routine histopathology as well as polymerase chain reaction (PCR) with panfungal/panoomycete primers and DNA sequencing on extracted DNA (DNA barcoding). Granulomatous, pyogranulomatous, and fibrinopurulent lesions in nasal and sinus mucosa were associated with signs of upper airway obstruction and noise as well as nasal discharge. Read More

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http://dx.doi.org/10.1177/0300985818817046DOI Listing
December 2018

An Unusual Case of Pulmonary Mucormycosis.

Transplant Proc 2018 Dec 6;50(10):3943-3945. Epub 2018 Jun 6.

Alice Springs Hospital, Northern Territory, Australia.

Invasive fungal infections in solid organ transplant recipients are associated with significant morbidity and mortality. Of these fungal infections, mucormycosis presents as an aggressive, frequently fatal angioinvasive infection. Immunocompromised hosts and diabetes are important risk factors. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183075
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http://dx.doi.org/10.1016/j.transproceed.2018.06.001DOI Listing
December 2018
4 Reads

Zygomycosis due to Mucor racemosus Associated with a Circovirus Infection in a Blue Tit (Cyanistes caeruleus).

J Comp Pathol 2018 Nov 1;165:67-71. Epub 2018 Nov 1.

Centre for Clinical Veterinary Medicine, Clinic for Birds, Small Mammals, Reptiles and Ornamental Fish, Ludwig-Maximilians-Universität München, Sonnenstrasse 18, Oberschleißheim, Germany.

In spring 2014, several wild passeriform garden birds were found severely ill or dead, all with severe periocular swellings. A blue tit (Cyanistes caeruleus) showing severe depression was humanely destroyed and sent for necropsy examination. In this bird, the lower eyelids were sagging, red and oedematous. Read More

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http://dx.doi.org/10.1016/j.jcpa.2018.09.011DOI Listing
November 2018
1 Read

[The treatment of mucormycosis (zygomycosis) in the 21st century].

Rev Iberoam Micol 2018 Oct - Dec;35(4):217-221. Epub 2018 Nov 22.

Unidad de Enfermedades Infecciosas, Hospital Universitario y Politécnico La Fe, Valencia, España. Electronic address:

Infections due to zygomycetes, caused by mucorales and entomophthorales, are characterized by angioinvasion and invasion of neighboring organs or structures. Mucorales most commonly cause rhinocerebral, pulmonary, cutaneous or disseminated infection and its spread is favored by several diseases (such as diabetes or chronic kidney disease) and risk factors (neutropenia, immunosuppression, iron overload). They have a high mortality rate, and the key to success in their treatment are early diagnosis, prompt administration of antifungal treatment, and extensive surgical debridement. Read More

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http://dx.doi.org/10.1016/j.riam.2018.09.001DOI Listing
November 2018
13 Reads

Healthcare burden of probable and proven invasive mucormycosis: a multi-centre cost-of-illness analysis of patients treated in tertiary care hospitals between 2003 and 2016.

J Hosp Infect 2019 Mar 10;101(3):339-346. Epub 2018 Nov 10.

University Hospital of Cologne, Department I of Internal Medicine, Cologne, Germany; German Centre for Infection Research, Partner Site Bonn-Cologne, Cologne, Germany.

Background: Invasive mucormycosis (IM) is a rare invasive fungal infection with a high mortality rate. However, data concerning the clinical and economic burden of IM are scarce.

Aim: To evaluate the direct treatment costs and additional expenditures of patients with IM. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01956701183058
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http://dx.doi.org/10.1016/j.jhin.2018.11.003DOI Listing
March 2019
21 Reads

Diagnosis and Treatment of Isolated Cerebral Mucormycosis: Patient-Level Data Meta-Analysis and Mayo Clinic Experience.

World Neurosurg 2019 Mar 9;123:425-434.e5. Epub 2018 Nov 9.

Department of Neurology, Mayo Clinic Health System-Franciscan Healthcare, La Crosse, Wisconsin, USA.

Background: Isolated cerebral mucormycosis is a rare and serious infection associated with intravenous drug abuse.

Methods: We performed a comprehensive meta-analysis of cases reported in studies and have included an unreported case from our institution. We searched PubMed/Medline, EMBASE, Scopus, Cochrane Databases, and our institution's electronic medical health records from inception through March 31, 2018. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.10.218DOI Listing
March 2019
3 Reads
2.420 Impact Factor

Isolated renal mucormycosis in a patient with Idiopathic CD4 lymphocytopenia.

BMJ Case Rep 2018 Nov 8;2018. Epub 2018 Nov 8.

Department of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Idiopathic CD4 lymphocytopenia (ICL) is characterised by a low CD4 +lymphocyte count in the absence of HIV or other underlying aetiologies. We report a case of a 17-year-old girl with ICL with autoimmune hepatitis who developed isolated renal mucormycosis, which, to our knowledge, is the first reported case described in literature. Combination therapy with antifungals and surgical resection was done, and the patient improved. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22523
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http://dx.doi.org/10.1136/bcr-2018-225234DOI Listing
November 2018
43 Reads

Invasive mucormycosis in children with cancer: A retrospective study from the Infection Working Group of Italian Pediatric Hematology Oncology Association.

Mycoses 2019 Feb 13;62(2):165-170. Epub 2018 Nov 13.

Pediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.

Background: Invasive mucormycosis is a rare but frequently fatal fungal disease. The acute and rapidly progressive evolution causes unfavourable outcome in 22%-59% of patients and its treatment represents a clinical challenge, especially in immunocompromised patients. Current data in paediatric oncological patients are limited. Read More

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http://dx.doi.org/10.1111/myc.12862DOI Listing
February 2019
10 Reads
1.805 Impact Factor

Recent advances in the understanding and management of mucormycosis.

F1000Res 2018 7;7. Epub 2018 Sep 7.

Paris Descartes University, Sorbonne Paris Cité, Infectious Diseases Unit, Necker-Enfants Malades University Hospital, AP-HP, Imagine Institute, Paris, France.

Mucormycoses were difficult-to-manage infections owing to limited diagnostic tools and therapeutic options. We review here advances in pathology understanding, diagnostic tools including computed tomography, and serum polymerase chain reaction and therapeutic options. Read More

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https://f1000research.com/articles/7-1429/v1
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http://dx.doi.org/10.12688/f1000research.15081.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134337PMC
February 2019
27 Reads

Pathways of Pathogenicity: Transcriptional Stages of Germination in the Fatal Fungal Pathogen .

mSphere 2018 09 26;3(5). Epub 2018 Sep 26.

Institute for Microbiology and Infection, School of Biosciences, University of Birmingham, Birmingham, United Kingdom

is an invasive fungal pathogen responsible for the frequently fatal disease mucormycosis. Germination, a crucial mechanism by which infectious spores of cause disease, is a key developmental process that transforms the dormant spore state into a vegetative one. The molecular mechanisms that underpin this transformation may be key to controlling mucormycosis; however, the regulation of germination remains poorly understood. Read More

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http://dx.doi.org/10.1128/mSphere.00403-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158513PMC
September 2018
18 Reads

Necrotizing fungal infection due to : A case report and review of literature.

Indian J Ophthalmol 2018 Oct;66(10):1513-1516

Department of Orbit, Oculoplasty, Reconstructive and Aesthetics, Medical Research Foundation, Chennai, Tamil Nadu, India.

Mucormycosis caused by Saksenaea erythrospora is an emerging infection seen with soil contamination, burns and/or nosocomial infections. PCR amplification and internal transcribed spacer sequencing is gold standard for its identification. Here, we report a case of necrotizing fungal orbital infection by S. Read More

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http://www.ijo.in/text.asp?2018/66/10/1513/242011
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http://dx.doi.org/10.4103/ijo.IJO_389_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173015PMC
October 2018
10 Reads

Mucormycosis outbreak due to Rhizopus microsporus after arthroscopic anterior cruciate ligament reconstruction surgery evaluated by RAPD and MALDI-TOF Mass spectrometry.

J Mycol Med 2018 Dec 22;28(4):617-622. Epub 2018 Sep 22.

Laboratorio de Micología y Diagnóstico Molecular (CONICET), Cátedra de Parasitología y Micología, Facultad de Bioquímica y Ciencias Biológicas, Ciudad Universitaria, Paraje el Pozo S/N, CP 3000 Santa Fe, Argentina; Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), CCT, Santa Fe, Argentina. Electronic address:

Background: Rhizopus microsporus is one of the main causative agents of mucormycosis. These mycoses are mostly described as isolated cases involving uncontrolled diabetes mellitus or immunosuppressed patients. In this work we report a nosocomial outbreak of mucormycosis due to R. Read More

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http://dx.doi.org/10.1016/j.mycmed.2018.09.002DOI Listing
December 2018
2 Reads

[Clinical high risk factors and prognosis of 25 pulmonary mucormycosis cases].

Zhonghua Yi Xue Za Zhi 2018 Aug;98(32):2579-2582

Department of Respiratory Medicine, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.

To analyze high risk factors, therapeutic regimen and prognosis of patients with pulmonary mucormycosis. A retrospective analysis was performed on the clinical data of 25 patients who were diagnosed as pulmonary mucormycosis in the First Affiliated Hospital, School of Medicine, Zhejiang University, between January 2009 and December 2017. Univariate analysis revealed that no risk factor had significant effect on prognosis of these 25 cases, while multivariate logistic regression analysis confirmed that the exposure to antifungal drugs was correlated to worse prognosis(=0. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2018.32.009DOI Listing
August 2018
23 Reads

Basidiobolomycosis in Togo: clinico-pathological study of a series of 12 presumed cases.

BMC Res Notes 2018 Sep 14;11(1):667. Epub 2018 Sep 14.

Department of Pathology, University Teaching Hospital of Lomé, Lomé, Togo.

Objective: The purpose of our study was to describe the histological diagnosed of the Basidiobolomycosis cases from 1990 to 2017 (28 years) in the only Pathology Anatomy Laboratory in Togo.

Results: A total of 12 cases of suspected Basidiobolomycosis have been identified. The sex ratio (M/F) was 2. Read More

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http://dx.doi.org/10.1186/s13104-018-3777-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137730PMC
September 2018
4 Reads

Tongue necrosis secondary to mucormycosis in a diabetic patient: A first case report in Malaysia.

J Mycol Med 2018 Sep 7;28(3):519-522. Epub 2018 Jul 7.

Department of Oral and Maxillofacial Surgery, Hospital Sungai Buloh, Selangor, Malaysia.

Mucormycosis is a rare fungal infection and high mortality that commonly affects patients with the weakened immune system. We present an unusual case of tongue necrosis probably due to the healthcare-associated mucormycosis (HCM) in a diabetic patient. Although cannot be proved with certainty, we surmise that intubation as a risk factor in our case. Read More

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http://dx.doi.org/10.1016/j.mycmed.2018.06.004DOI Listing
September 2018

Pulmonary Campylobacter concisus infection in an immunocompromised patient with underlying mucormycosis.

Int J Infect Dis 2018 Nov 8;76:45-47. Epub 2018 Sep 8.

Institute of Medical Microbiology and Hygiene, University Hospital of Ulm, Albert-Einstein-Allee 23, D-89081 Ulm, Germany.

Campylobacter concisus is a rarely encountered agent of human infection. The first isolation of C. concisus from a pulmonary abscess in an immunocompromised patient who underwent allogeneic stem cell transplantation is reported here. Read More

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http://dx.doi.org/10.1016/j.ijid.2018.08.021DOI Listing
November 2018
5 Reads

Staring at the stars: a case of gastrointestinal basidiobolomycosis from the Indian subcontinent.

BMJ Case Rep 2018 Sep 5;2018. Epub 2018 Sep 5.

Medicine, All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.1136/bcr-2018-226693DOI Listing
September 2018
3 Reads

Primary Oral Mucormycosis Due to Rhizopus microsporus after Allogeneic Stem Cell Transplantation.

Intern Med 2018 1;57(17):2567-2571. Epub 2018 Sep 1.

Department of Hematology, Nagasaki University Hospital, Japan.

We herein report a rare case of oral mucormycosis following allogeneic hematopoietic stem cell transplantation. Oral mucormycosis due to Rhizopus microsporus manifested as localized left buccal mucositis with a 1-cm black focus before neutrophil recovery. Combination therapy with liposomal amphotericin B was initiated and surgical debridement was performed; however, the patient died due to progressive generalized mucormycosis. Read More

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http://dx.doi.org/10.2169/internalmedicine.0474-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172532PMC
November 2018
3 Reads

Rhinocerebral Zygomycosis Due to a Lichtheimia ramosa Infection in a Calf: Neural Spread Through the Olfactory Nerves.

Mycopathologia 2019 Feb 30;184(1):141-146. Epub 2018 Aug 30.

Research Center for Global Agromedicine, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-11, Obihiro-Shi, Hokkaido, 080-8555, Japan.

Here, we report a case of rhinocerebral zygomycosis due to a Lichtheimia ramosa infection in a calf. A histopathological examination revealed that a fungus had invaded the brain through the olfactory nerves. Lichtheimia ramosa was detected by polymerase chain reaction analysis of DNA extracted from formalin-fixed paraffin-embedded samples of the affected tissue. Read More

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http://dx.doi.org/10.1007/s11046-018-0296-zDOI Listing
February 2019
2 Reads

Human Pathogenic Entomophthorales.

Clin Microbiol Rev 2018 10 29;31(4). Epub 2018 Aug 29.

Biomedical Laboratory Diagnostics, Michigan State University, East Lansing, Michigan, USA

The pathogenic entomophthoralean fungi cause infection in insects and mammalian hosts. and species can be found in soil and insect, reptile, and amphibian droppings in tropical and subtropical areas. The life cycles of these fungi occur in these environments where infecting sticky conidia are developed. Read More

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http://dx.doi.org/10.1128/CMR.00014-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148186PMC
October 2018
22 Reads

A Case Report of Mucormycosis with Palatal Ulcer: A Rare Clinical Dilemma.

J Coll Physicians Surg Pak 2018 Sep;28(9):721-723

Department of General Medicine, Suyash Multispeciality Hospital, Nashik, India.

Mucormycosis represents a group of life-threatening infections caused by fungi of the order mucorales of subphylum mucormycotina (formely known as the class zygomycetes). It is highly invasive and progressive disease resulting in higher rates of morbidity and mortality. Newer therapies have declined the rates of mortality. Read More

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http://dx.doi.org/10.29271/jcpsp.2018.09.721DOI Listing
September 2018
1 Read

Iron restriction inside macrophages regulates pulmonary host defense against Rhizopus species.

Nat Commun 2018 08 20;9(1):3333. Epub 2018 Aug 20.

Department of Medicine, University of Crete, Foundation for Research and Technology, 71300, Heraklion, Crete, Greece.

Mucormycosis is a life-threatening respiratory fungal infection predominantly caused by Rhizopus species. Mucormycosis has incompletely understood pathogenesis, particularly how abnormalities in iron metabolism compromise immune responses. Here we show how, as opposed to other filamentous fungi, Rhizopus spp. Read More

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http://www.nature.com/articles/s41467-018-05820-2
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http://dx.doi.org/10.1038/s41467-018-05820-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102248PMC
August 2018
25 Reads
10.742 Impact Factor

Mucormycosis in hospitalized patients at a tertiary care center in Lebanon: a case series.

Infection 2018 Dec 18;46(6):811-821. Epub 2018 Aug 18.

Division of Infectious Diseases, American University of Beirut Medical Center, Riad El Solh, PO Box 11-0236, Beirut, 1107 2020, Lebanon.

Purpose: Mucormycosis (MCM) is a rare fungal infection affecting people with impaired immunity. Data related to MCM from Lebanon are scarce. The aim of this study is to shed light on the epidemiology, incidence, and outcome of patients with MCM hospitalized at a tertiary care center in Lebanon. Read More

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http://dx.doi.org/10.1007/s15010-018-1195-4DOI Listing
December 2018
23 Reads

Inhibition of EGFR Signaling Protects from Mucormycosis.

MBio 2018 08 14;9(4). Epub 2018 Aug 14.

Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA

Mucormycosis is a life-threatening, invasive fungal infection that is caused by various species belonging to the order Mucorales. species are the most common cause of the disease, responsible for approximately 70% of all cases of mucormycosis. During pulmonary mucormycosis, inhaled spores must adhere to and invade airway epithelial cells in order to establish infection. Read More

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http://dx.doi.org/10.1128/mBio.01384-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094478PMC
August 2018
26 Reads
6.790 Impact Factor

Angioinvasive fungal infections impacting the skin: Background, epidemiology, and clinical presentation.

J Am Acad Dermatol 2019 Apr 10;80(4):869-880.e5. Epub 2018 Aug 10.

Department of Dermatology and Pathology, University of Iowa, Iowa City, Iowa. Electronic address:

Angioinvasive fungal infections cause significant morbidity and mortality because of their propensity to invade blood vessel walls, resulting in catastrophic tissue ischemia, infarct, and necrosis. While occasionally seen in immunocompetent hosts, opportunistic fungi are emerging in immunosuppressed hosts, including patients with hematologic malignancy, AIDS, organ transplant, and poorly controlled diabetes mellitus. The widespread use of antifungal prophylaxis has led to an "arms race" of emerging fungal resistance patterns. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.04.059DOI Listing
April 2019
19 Reads

Rare mould infections caused by Mucorales, Lomentospora prolificans and Fusarium, in San Diego, CA: the role of antifungal combination therapy.

Int J Antimicrob Agents 2018 Nov 9;52(5):706-712. Epub 2018 Aug 9.

Department of Medicine, University of California, San Diego, San Diego, CA, USA; Department of Medicine, Medical University of Graz, Graz, Austria. Electronic address:

Non-Aspergillus invasive mould infections (IMIs) are associated with devastating morbidity and mortality rates and are increasingly diagnosed in immunocompromised hosts. The aim of this study was to describe the epidemiology and outcomes of non-Aspergillus IMIs at a university hospital in San Diego, California, USA. A retrospective chart review of the medical records of all patients with cultures growing non-Aspergillus moulds at the microbiology laboratory in the Center for Academic Laboratory Medicine, Department of Pathology, University of California, San Diego (UCSD) Health between mid-2014 and mid-2017 (3-year period) was performed. Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2018.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231988PMC
November 2018
16 Reads

Identification of Mucorales in patients with proven invasive mucormycosis by polymerase chain reaction in tissue samples.

Mycoses 2018 Dec 28;61(12):909-915. Epub 2018 Aug 28.

Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Background: Accurate diagnosis of mucormycosis, a life-threatening fungal infection, remains a challenge for physicians.

Objectives: To identify the causative Mucorales in fresh clinical samples and formalin-fixed paraffin-embedded (FFPE) samples of patients with proven mucormycosis by molecular method.

Patients/methods: Fresh clinical samples of patients with proven mucormycosis according to the EORTC/MSG criteria admitted between 2015 and 2017 and histopathologically proven FFPE archives collected during 2004-2007 and 2015-2017 from Mazandaran University-affiliated hospitals of northern Iran were included. Read More

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http://dx.doi.org/10.1111/myc.12837DOI Listing
December 2018
22 Reads

Cutaneous mucormycosis.

Infection 2018 Dec 8;46(6):901-902. Epub 2018 Aug 8.

School of Medicine, Chang Gung University, Kweishan Township, Taoyuan, Taiwan.

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http://dx.doi.org/10.1007/s15010-018-1179-4DOI Listing
December 2018

Diagnosis of invasive fungal disease in hospitalized patients with chronic obstructive pulmonary disease.

Rev Iberoam Micol 2018 Jul - Sep;35(3):117-122. Epub 2018 Aug 2.

Servicio de Microbiología y Parasitología Clínica, Hospital Universitario Severo Ochoa de Madrid, Avda/ de Orellana s/n, 28911 Leganés, Spain.

Background: The role of culture-independent techniques (galactomannan, (1-3)-β-d-glucan) in the early diagnosis of invasive fungal diseases (IFD) is well assessed in hematological patients, but there are no clear conclusions in patients with chronic obstructive pulmonary disease (COPD).

Aims: To study the usefulness of nonculture-based techniques in the diagnosis of IFD in COPD-patients at risk for IFD.

Methods: A prospective observational study based on monitoring COPD patients at risk for IFD during 2007-2010 was carried out. Read More

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http://dx.doi.org/10.1016/j.riam.2017.07.004DOI Listing
August 2018
3 Reads

Cutaneous Mucormycosis by Saksenaea vasiformis: An Unusual Case Report and Review of Literature.

Mycopathologia 2019 Feb 30;184(1):159-167. Epub 2018 Jul 30.

First Department of General Surgery, General Hospital of Attica "KAT", 141 Oropou Str., 14232, Athens, Greece.

Background: Saksenaea vasiformis is one of the numerous fungi of the Order Mucorales. Rapid progression and invasion of neighboring tissues are the most characteristic features of S. vasiformis mucormycosis. Read More

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http://dx.doi.org/10.1007/s11046-018-0249-6DOI Listing
February 2019
18 Reads

Combined Medical and Surgical Management of Hepatic Mucormycosis in an Adult with Acute Myeloid Leukemia: Case Report and Review of the Literature.

Mycopathologia 2019 Feb 30;184(1):155-158. Epub 2018 Jul 30.

Departments of Surgery, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

Hepatic mucormycosis is a disease caused by a ubiquitous fungus which is especially important in patients with hematologic malignancies. We present a case of an adult patient with acute myeloid leukemia who developed the infection after undergoing chemotherapy. His successful management was an integrated approach of a minimally invasive surgical resection with anti-fungal therapy. Read More

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http://link.springer.com/10.1007/s11046-018-0289-y
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http://dx.doi.org/10.1007/s11046-018-0289-yDOI Listing
February 2019
5 Reads

Mucor mycelial thrombosis of the portal vein in an extremely low-birthweight infant.

Pediatr Int 2018 Aug 30;60(8):764-766. Epub 2018 Jul 30.

Department of Pathology, Kanagawa Children's Medical Center, Yokohama, Japan.

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http://dx.doi.org/10.1111/ped.13611DOI Listing
August 2018
2 Reads