4,761 results match your criteria Zygomycosis


A Comparative Analysis of Mucormycosis in Immunosuppressed hosts Including Patients with Uncontrolled Diabetes in the Southwest United States.

Am J Med 2021 May 8. Epub 2021 May 8.

Division of Infectious Diseases, Banner University Medical Center, University of Arizona, Tucson, United States.

Background: Mucormycosis (Zygomycosis) is an invasive fungal infection that carries a high risk of morbidity and mortality. Uncontrolled diabetes mellitus and other immunocompromising conditions are risk factors for Mucormycosis development. We here describe the differences in characteristics and outcomes of Mucormycosis among solid organ transplant, hematological malignancy, and diabetes mellitus groups at our institution. Read More

View Article and Full-Text PDF

Basidiobolomycosis: Case Report and Literature Overview.

Indian Dermatol Online J 2021 Mar-Apr;12(2):307-311. Epub 2021 Mar 2.

Department of Dermatology, Venereology and Leprosy, Kalinga Institute of Medical Sciences (KIMS), Bhubaneswar, Odisha, India.

Basidiobolomycosis or subcutaneous zygomycosis or subcutaneous phycomycosis is a chronic granulomatous infection of skin and subcutaneous tissue, caused by a saprophytic filamentous fungus, , clinically characterized by firm, painless subcutaneous swelling with smooth and rounded edges. Histopathological features include the peculiar Splendore-Hoeppli phenomenon. Culture on Sabouraud dextrose agar shows creamy white, heaped up, and furrowed colonies. Read More

View Article and Full-Text PDF

COVID-19 triggering mucormycosis in a susceptible patient: a new phenomenon in the developing world?

BMJ Case Rep 2021 Apr 27;14(4). Epub 2021 Apr 27.

General Medicine, Nitte University K S Hegde Medical Academy, Mangalore, Karnataka, India.

A middle-aged woman with diabetes presented with left-sided facial pain, complete ptosis and fever of short duration. On presentation, she had hyperglycaemia without ketosis. There was total ophthalmoplegia of the left eye with a visual acuity of 6/36. Read More

View Article and Full-Text PDF

Mucormycosis after Coronavirus disease 2019 infection in a heart transplant recipient - Case report and review of literature.

J Mycol Med 2021 Apr 2;31(2):101125. Epub 2021 Apr 2.

Division of Infectious Diseases, Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health, 400 Community Drive, Infectious Diseases Suite, 11030 Manhasset, NY, USA. Electronic address:

Mucormycosis is an invasive fungal infection (IFI) due to several species of saprophytic fungi, occurring in patients with underlying co-morbidities (including organ transplantation). During the ongoing Coronavirus disease 2019 (COVID-19) pandemic, there have been increasing reports of bacterial and fungal co-infections occurring in COVID-19 patients, including COVID-19 associated pulmonary aspergillosis (CAPA). We describe a case of mucormycosis occurring after COVID-19, in an individual who received a recent heart transplant for severe heart failure. Read More

View Article and Full-Text PDF

Hyperbaric oxygen treatment: Results in seven patients with severe bacterial postoperative central nervous system infections and refractory mucormycosis.

Diving Hyperb Med 2021 Mar;51(1):86-93

Neurosurgery Department, Centro Hospitalar Universitário São João, Oporto, Portugal.

Introduction: Resistant bacterial infections following brain and spine surgery and spontaneous mucormycosis with central nervous system (CNS) involvement represent a serious treatment challenge and more efficient therapeutic approaches ought to be considered. Hyperbaric oxygen treatment (HBOT) has shown promise as a complementary therapy. This case series evaluated whether HBOT contributed to infection resolution in seven patients with refractory CNS infectious conditions. Read More

View Article and Full-Text PDF

COVID-19 and orbital mucormycosis.

Indian J Ophthalmol 2021 04;69(4):1002-1004

Department of Ophthalmology, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India.

View Article and Full-Text PDF

Role of flexible bronchoscopy in the diagnosis of invasive fungal infections.

Mycoses 2021 Jun 14;64(6):668-677. Epub 2021 Mar 14.

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Background: There are sparse data on the role of flexible bronchoscopy (FB) in diagnosing invasive mould infections (IMIs).

Objective: To investigate the safety and usefulness of FB in IMI. We evaluate the factors associated with a successful diagnosis of IMI using FB. Read More

View Article and Full-Text PDF

Guidance on Imaging for Invasive Pulmonary Aspergillosis and Mucormycosis: From the Imaging Working Group for the Revision and Update of the Consensus Definitions of Fungal Disease from the EORTC/MSGERC.

Clin Infect Dis 2021 03;72(Suppl 2):S79-S88

Division of Infectious Diseases, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Background: Clinical imaging in suspected invasive fungal disease (IFD) has a significant role in early detection of disease and helps direct further testing and treatment. Revised definitions of IFD from the EORTC/MSGERC were recently published and provide clarity on the role of imaging for the definition of IFD. Here, we provide evidence to support these revised diagnostic guidelines. Read More

View Article and Full-Text PDF

Mucormycosis in a pediatric population: a review of 20 cases from southern Turkey.

Turk J Pediatr 2021 ;63(1):11-22

Departments of Pediatric Hematology and Oncology, Çukurova University Faculty of Medicine, Adana, Turkey.

Background: Mucormycosis is a fatal invasive fungal infection seen most often in patients with compromised defense mechanisms. The aim of this article was to review the data of pediatric mucor in the South of Turkey.

Methods: Twenty pediatric cases with biopsy proven mucormycosis were reported, between January 2007 through January 2017. Read More

View Article and Full-Text PDF
January 2021

hepatosplenic abscesses in a patient with renal and pancreatic transplantation.

Ann R Coll Surg Engl 2021 Apr 8;103(4):e131-e135. Epub 2021 Mar 8.

Lausanne University Hospital and University of Lausanne, Switzerland.

Fungal infections are generally observed in immunosuppressed patients only, with a diagnostic challenge due to non-specific symptoms. For this reason, appropriate management may be delayed. This case report concerns a 36-year-old man with history of pancreas and kidney transplantation. Read More

View Article and Full-Text PDF

Mucormycosis originated total maxillary and cranial base osteonecrosis: a possible misdiagnosis to malignancy.

BMC Oral Health 2021 02 12;21(1):65. Epub 2021 Feb 12.

Department of Oral and Maxillofacial Surgery, School of Medicine, Ewha Womans University Medical Center, Mokdong Hospital, Anyangcheon-ro 1071, Yangcheon-gu, Seoul, 158-710, Korea.

Background: This is a case of mucormycosis originated osteonecrosis of the maxilla extended to the cranial base, initially suspected of malignancy. The patient was first suspected with osteolytic sarcomatous lesion but was later diagnosed with total maxillary necrosis and cranial base through biopsy-proven invasive mucormycosis.

Case Presentation: A 71-year-old male was presented with unknown total maxillary osteonecrosis. Read More

View Article and Full-Text PDF
February 2021

Oral posaconazole and bronchoscopy as a treatment for pulmonary mucormycosis in pediatric acute lymphoblastic leukemia patient: A case report.

Medicine (Baltimore) 2021 Feb;100(6):e24630

Department of Pediatric Respiratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.

Rationale: Mucormycosis is a rare fungal infection that typically occurs in immunosuppressed patients following chemotherapy or hematopoietic stem cell transplantation.

Patient Concerns: An 11-year-old child with newly developed acute lymphoblastic leukemia suffered from the paroxysmal left chest pain, fever, and hemoptysis.

Diagnoses: We made a histopathologic diagnosis aided by bronchoscopy techniques, which indicated invasive fungal hyphae that are characteristic of mucormycosis. Read More

View Article and Full-Text PDF
February 2021

Coronavirus Disease (Covid-19) Associated Mucormycosis (CAM): Case Report and Systematic Review of Literature.

Mycopathologia 2021 May 5;186(2):289-298. Epub 2021 Feb 5.

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Sector-12, Chandigarh, 160012, India.

Severe coronavirus disease (COVID-19) is currently managed with systemic glucocorticoids. Opportunistic fungal infections are of concern in such patients. While COVID-19 associated pulmonary aspergillosis is increasingly recognized, mucormycosis is rare. Read More

View Article and Full-Text PDF

Rhinocerebral mucormycosis to the rise? The impact of the worldwide diabetes epidemic.

An Bras Dermatol 2021 Mar-Apr;96(2):196-199. Epub 2021 Jan 23.

General Hospital Dr. Manuel Gea González Calzada de Tlalpan, Tlalpan, Ciudad de México, México. Electronic address:

The authors present seven cases of rhinocerebral mucormycosis associated to diabetes mellitus, which is a disease with epidemic proportions affecting individuals worldwide, particularly in developing countries, and which poses significant morbidity and mortality. Mucormycosis is an opportunistic fungal infection with high mortality and requires an invasive therapeutic approach to save the patient's life with significant morbidity and sequelae, thus prevention is crucial. Read More

View Article and Full-Text PDF

Fatal Cutaneous Zygomycosis caused by Saksaenea Vasiformis.

J Assoc Physicians India 2021 Feb;69(2):71-72

Consultant Microbiologist, Unipath Specialty Laboratory Limited, Ahmedabad, Gujarat.

Fungi in the class of zygomycetes usually produce serious infections in diabetics and immunocompromised hosts. Cutaneous zygomycosis is a less common form, with an unpredictable extent of anatomical involvement and clinical course1.¹ Here, we report a case of primary cutaneous zygomycosis caused by saksaenea vasiformis as posttraumatic complications in a diabetic female. Read More

View Article and Full-Text PDF
February 2021

Disseminated and ulcerative basidiobolomycosis simulating a Buruli ulcer in an immunocompetent girl in Southern Benin.

Pan Afr Med J 2020 11;37:227. Epub 2020 Nov 11.

Centre de Dépistage et de Traitement de la Lèpre et de l´Ulcère de Buruli de Pobè, Fondation Raoul Follereau, Cotonou, Bénin.

Basidiobolomycosis is a subcutaneous mycosis, for which non-specific clinical presentation can be a source of diagnostic wandering. A 5-year-old girl was brought for consultation with chronic ulcers of the pelvic limbs evolving for 8 months. The lesions started when the girl was 18 months old with a painless, pruritic nodule of the right buttock, indurated placard following progressive extension to the pelvic limbs, back and abdomen, and secondarily ulcerated in several places. Read More

View Article and Full-Text PDF

Incidence, predisposing conditions and outcomes of cutaneous mucormycosis: A national database study.

Mycoses 2021 May 31;64(5):569-572. Epub 2021 Jan 31.

Department of Internal Medicine, University of Kentucky College of Medicine, Lexington, KY, USA.

Background: The body of evidence on cutaneous mucormycosis is largely derived from case reports or single-centre databases.

Objectives: Our study aimed to describe incidence, predisposing factors and inpatient outcomes of cutaneous mucormycosis in the United States.

Methods: We conducted a population-based retrospective study using the National Inpatient Sample 2016-17 data. Read More

View Article and Full-Text PDF

Thoracic mucormycosis in immunocompetent patients.

J Card Surg 2021 Apr 19;36(4):1183-1188. Epub 2021 Jan 19.

Department of Cardiothoracic and Vascular Surgery, JIPMER, Pondicherry, India.

Background: Mucormycosis is an invasive fungal infection. It is rare and commonly associated with fatal outcomes.

Methods: We report two cases of thoracic mucormycosis in immunocompetent patients. Read More

View Article and Full-Text PDF

Gastrointestinal Zygomycosis in a Preterm Neonate Associated With Contaminated Probiotics.

Pediatr Infect Dis J 2021 Apr;40(4):365-367

Pharmacy Services, Yale-New Haven Hospital, New Haven, Connecticut.

A neonate of 29 weeks' gestation who received probiotics developed clinical signs suggesting surgical necrotizing enterocolitis. A specimen of resected ileum revealed fungal forms within the bowel wall. Rhizopus oryzae was detected via DNA sequencing from probiotic powder and tissue specimens from the infant. Read More

View Article and Full-Text PDF

Mucor in a Viral Land: A Tale of Two Pathogens.

Indian J Ophthalmol 2021 02;69(2):244-252

Ophthalmic and Facial Plastic Surgery and Ocular Oncology Services, Centre for Sight, Hyderabad, India.

Purpose: COVID-19 infection, its treatment, resultant immunosuppression, and pre-existing comorbidities have made patients vulnerable to secondary infections including mucormycosis. It is important to understand the presentation, temporal sequence, risk factors, and outcomes to undertake measures for prevention and treatment.

Methods: We conducted a retrospective, interventional study on six consecutive patients with COVID-19 who developed rhino-orbital mucormycosis and were managed at two tertiary ophthalmic referral centers in India between August 1 and December 15, 2020. Read More

View Article and Full-Text PDF
February 2021

Unusual presentation of mucormycosis mimicking a localised sino-orbital pathology.

BMJ Case Rep 2021 Jan 11;14(1). Epub 2021 Jan 11.

OMFS, Pravara Rural Dental College, Ahmednagar, Maharashtra, India.

Mucormycosis is an aggressive and deadly fungal infection, which is invariably associated with an immunocompromised patient. Mucormycosis in the head and neck region presents as skeletal necrosis, with or without soft tissue involvement. Early identification and treatment with combination of surgical debridement and parenteral antifungal therapy is critical for a favourable outcome. Read More

View Article and Full-Text PDF
January 2021

Skull base osteomyelitis with secondary cavernous sinus thrombosis: a rare presentation of an animate foreign body in the ear.

BMJ Case Rep 2021 Jan 11;14(1). Epub 2021 Jan 11.

Department of ENT-Otology, Neurotology & Cochlear Implant Unit, Christian Medical College and Hospital Vellore, Vellore, India.

A 42-year-old woman presented with fever, left ear pain, restricted mouth opening, difficulty in swallowing and inability to open her left eyelid for a period of 10 days. She was treated with antibiotics for the same at a local medical facility; however, a sudden decrease in her left eye vision prompted her to visit our tertiary centre. Her history was insignificant except for having multiple left ear syringing for an insect removal 10 days before onset of her current symptoms. Read More

View Article and Full-Text PDF
January 2021

Has the mortality from pulmonary mucormycosis changed over time? A systematic review and meta-analysis.

Clin Microbiol Infect 2021 Apr 5;27(4):538-549. Epub 2021 Jan 5.

Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Objectives: Pulmonary mucormycosis (PM) is increasingly being reported in immunocompromised patients and has a high mortality. Our aim was to assess the mortality of PM and its trend over time. We also evaluated the role of combined medical-surgical therapy in PM. Read More

View Article and Full-Text PDF

A rare case of colon obstruction due to gastrointestinal basidiobolomycosis in a 36-year-old woman.

Int J Surg Case Rep 2020 24;77:762-765. Epub 2020 Nov 24.

General Surgery Department, Security Forces Hospital, Riyadh, Saudi Arabia. Electronic address:

Introduction: Gastrointestinal basidiobolomycosis (GIB) is an uncommon fungal infection caused byBasidiobolus ranarum, with less than 80 cases reported in the literature.

Presentation Of Case: A 36-year-old woman presented with colicky upper abdominal pain for 2 months and inability to pass stool for 2 days. Computed tomography of the abdomen and colonoscopy both showed a mass in the transverse colon. Read More

View Article and Full-Text PDF
November 2020

Molecular epidemiology of zygomycosis and their related factors in tertiary referral centers in southern Iran.

J Infect Dev Ctries 2020 12 31;14(12):1424-1430. Epub 2020 Dec 31.

Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Introduction: For the best management of the zygomycosis in immunocompromised patients, the present study aims to detect and identify the etiologic agents by DNA sequencing method and their related factors in clinical samples of patients.

Methodology: Clinical samples from 1,058 patients admitted in 11 university hospitals in Shiraz, Southern Iran were collected between July 2015 and July 2018. All samples (bronchoalveolar lavage, sputum, blood, tissue) were examined by routine microscopic and culture tests for zygomycetes. Read More

View Article and Full-Text PDF
December 2020

For Whom the Atoll Tolls: Targeting the Reversed Halo Sign.

Am J Med 2021 03 25;134(3):e150-e152. Epub 2020 Oct 25.

Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Westchester Medical Center, Valhalla, NY.

View Article and Full-Text PDF

The Postmortem Features of Mucormycosis.

Acad Forensic Pathol 2020 Jun 25;10(2):72-80. Epub 2020 Nov 25.

Mucormycosis is a rare and severe invasive fungal infection caused by ubiquitous fungi of the order Mucorales. Infection often occurs in immunocompromised hosts and includes cutaneous, pulmonary, gastrointestinal, rhinocerebral, and disseminated forms of disease. Although the clinical characteristics of mucormycosis are well established, infection can be difficult to diagnose antemortem, resulting in frequent postmortem diagnoses. Read More

View Article and Full-Text PDF

Pulmonary mucormycosis: A case report.

IDCases 2020 1;22:e00993. Epub 2020 Nov 1.

Infectious Diseases Department, Centro Hospitalar São João, Portugal.

Mucormycosis is a rare fungal infection caused by Mucorales order fungi. The rhino-cerebral form of mucormycosis is most commonly seen in patients with diabetes mellitus, whereas, pulmonary mucormycosis is a rare manifestation in patients with haematological malignancy and transplant recipients. We report a case of pulmonary mucormycosis presenting with a late acute onset diabetes on a patient immunosuppressed with a low dose of steroids. Read More

View Article and Full-Text PDF
November 2020

Acute Invasive Rhino-Orbital Mucormycosis in a Patient With COVID-19-Associated Acute Respiratory Distress Syndrome.

Ophthalmic Plast Reconstr Surg 2021 Mar-Apr 01;37(2):e40-e80

Department of Ophthalmology.

Acute invasive fungal rhinosinusitis is a rare, although highly morbid, infection primarily affecting immunosuppressed individuals. The same population is at particularly high risk of complications and mortality in the setting of SARS-CoV-2 infection and coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome. The authors present a case of acute invasive fungal rhino-orbital mucormycosis in a patient with COVID-19 and discuss the prevalence, diagnosis, and treatment of fungal coinfections in COVID-19. Read More

View Article and Full-Text PDF

Mucormycosis in the Jaw: A Report of 2 Cases and Literature Review.

Oral Health Prev Dent 2020 11 20;18(1):1011-1016. Epub 2020 Nov 20.

Mucormycosis is a rare fungal infection with high morbidity and mortality and a very poor prognosis. However, aggressive medical and surgical management can result in survival rates exceeding 80%. The most common sites involved in mucormycosis infection are the sinus, lung, skin and soft tissues, gastrointestinal system, central nervous system, and rarely the mandible. Read More

View Article and Full-Text PDF
November 2020