4,357 results match your criteria Zygomycosis
J Comp Pathol 2018 Nov 1;165:67-71. Epub 2018 Nov 1.
Centre for Clinical Veterinary Medicine, Clinic for Birds, Small Mammals, Reptiles and Ornamental Fish, Ludwig-Maximilians-Universität München, Sonnenstrasse 18, Oberschleißheim, Germany.
In spring 2014, several wild passeriform garden birds were found severely ill or dead, all with severe periocular swellings. A blue tit (Cyanistes caeruleus) showing severe depression was humanely destroyed and sent for necropsy examination. In this bird, the lower eyelids were sagging, red and oedematous. Read More
Rev Iberoam Micol 2018 Nov 21. Epub 2018 Nov 21.
Unidad de Enfermedades Infecciosas, Hospital Universitario y Politécnico La Fe, Valencia, España. Electronic address:
Infections due to zygomycetes, caused by mucorales and entomophthorales, are characterized by angioinvasion and invasion of neighboring organs or structures. Mucorales most commonly cause rhinocerebral, pulmonary, cutaneous or disseminated infection and its spread is favored by several diseases (such as diabetes or chronic kidney disease) and risk factors (neutropenia, immunosuppression, iron overload). They have a high mortality rate, and the key to success in their treatment are early diagnosis, prompt administration of antifungal treatment, and extensive surgical debridement. Read More
Indian J Ophthalmol 2018 Oct;66(10):1513-1516
Department of Orbit, Oculoplasty, Reconstructive and Aesthetics, Medical Research Foundation, Chennai, Tamil Nadu, India.
Mucormycosis caused by Saksenaea erythrospora is an emerging infection seen with soil contamination, burns and/or nosocomial infections. PCR amplification and internal transcribed spacer sequencing is gold standard for its identification. Here, we report a case of necrotizing fungal orbital infection by S. Read More
Zhonghua Yi Xue Za Zhi 2018 Aug;98(32):2579-2582
Department of Respiratory Medicine, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
To analyze high risk factors, therapeutic regimen and prognosis of patients with pulmonary mucormycosis. A retrospective analysis was performed on the clinical data of 25 patients who were diagnosed as pulmonary mucormycosis in the First Affiliated Hospital, School of Medicine, Zhejiang University, between January 2009 and December 2017. Univariate analysis revealed that no risk factor had significant effect on prognosis of these 25 cases, while multivariate logistic regression analysis confirmed that the exposure to antifungal drugs was correlated to worse prognosis(=0. Read More
BMC Res Notes 2018 Sep 14;11(1):667. Epub 2018 Sep 14.
Department of Pathology, University Teaching Hospital of Lomé, Lomé, Togo.
Objective: The purpose of our study was to describe the histological diagnosed of the Basidiobolomycosis cases from 1990 to 2017 (28 years) in the only Pathology Anatomy Laboratory in Togo.
Results: A total of 12 cases of suspected Basidiobolomycosis have been identified. The sex ratio (M/F) was 2. Read More
J Mycol Med 2018 Sep 7;28(3):519-522. Epub 2018 Jul 7.
Department of Oral and Maxillofacial Surgery, Hospital Sungai Buloh, Selangor, Malaysia.
Mucormycosis is a rare fungal infection and high mortality that commonly affects patients with the weakened immune system. We present an unusual case of tongue necrosis probably due to the healthcare-associated mucormycosis (HCM) in a diabetic patient. Although cannot be proved with certainty, we surmise that intubation as a risk factor in our case. Read More
Intern Med 2018 1;57(17):2567-2571. Epub 2018 Sep 1.
Department of Hematology, Nagasaki University Hospital, Japan.
We herein report a rare case of oral mucormycosis following allogeneic hematopoietic stem cell transplantation. Oral mucormycosis due to Rhizopus microsporus manifested as localized left buccal mucositis with a 1-cm black focus before neutrophil recovery. Combination therapy with liposomal amphotericin B was initiated and surgical debridement was performed; however, the patient died due to progressive generalized mucormycosis. Read More
Mycopathologia 2018 Aug 30. Epub 2018 Aug 30.
Research Center for Global Agromedicine, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-11, Obihiro-Shi, Hokkaido, 080-8555, Japan.
Here, we report a case of rhinocerebral zygomycosis due to a Lichtheimia ramosa infection in a calf. A histopathological examination revealed that a fungus had invaded the brain through the olfactory nerves. Lichtheimia ramosa was detected by polymerase chain reaction analysis of DNA extracted from formalin-fixed paraffin-embedded samples of the affected tissue. Read More
J Coll Physicians Surg Pak 2018 Sep;28(9):721-723
Department of General Medicine, Suyash Multispeciality Hospital, Nashik, India.
Mucormycosis represents a group of life-threatening infections caused by fungi of the order mucorales of subphylum mucormycotina (formely known as the class zygomycetes). It is highly invasive and progressive disease resulting in higher rates of morbidity and mortality. Newer therapies have declined the rates of mortality. Read More
Int J Antimicrob Agents 2018 Nov 9;52(5):706-712. Epub 2018 Aug 9.
Department of Medicine, University of California, San Diego, San Diego, CA, USA; Department of Medicine, Medical University of Graz, Graz, Austria. Electronic address:
Non-Aspergillus invasive mould infections (IMIs) are associated with devastating morbidity and mortality rates and are increasingly diagnosed in immunocompromised hosts. The aim of this study was to describe the epidemiology and outcomes of non-Aspergillus IMIs at a university hospital in San Diego, California, USA. A retrospective chart review of the medical records of all patients with cultures growing non-Aspergillus moulds at the microbiology laboratory in the Center for Academic Laboratory Medicine, Department of Pathology, University of California, San Diego (UCSD) Health between mid-2014 and mid-2017 (3-year period) was performed. Read More
Rev Iberoam Micol 2018 Jul - Sep;35(3):117-122. Epub 2018 Aug 2.
Servicio de Microbiología y Parasitología Clínica, Hospital Universitario Severo Ochoa de Madrid, Avda/ de Orellana s/n, 28911 Leganés, Spain.
Background: The role of culture-independent techniques (galactomannan, (1-3)-β-d-glucan) in the early diagnosis of invasive fungal diseases (IFD) is well assessed in hematological patients, but there are no clear conclusions in patients with chronic obstructive pulmonary disease (COPD).
Aims: To study the usefulness of nonculture-based techniques in the diagnosis of IFD in COPD-patients at risk for IFD.
Methods: A prospective observational study based on monitoring COPD patients at risk for IFD during 2007-2010 was carried out. Read More
Mycopathologia 2018 Jul 30. Epub 2018 Jul 30.
First Department of General Surgery, General Hospital of Attica "KAT", 141 Oropou Str., 14232, Athens, Greece.
Background: Saksenaea vasiformis is one of the numerous fungi of the Order Mucorales. Rapid progression and invasion of neighboring tissues are the most characteristic features of S. vasiformis mucormycosis. Read More
Pediatr Int 2018 Aug 30;60(8):764-766. Epub 2018 Jul 30.
Department of Pathology, Kanagawa Children's Medical Center, Yokohama, Japan.
BMJ Case Rep 2018 Jul 18;2018. Epub 2018 Jul 18.
Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA.
We report a case of a complex orthopaedic infection in a patient returning to New York City from Bangladesh where he was involved in a serious motor vehicle accident. He developed extensive osteomyelitis with a carbapenem-resistant The isolate was unique due to the coexistence of New Delhi metallo-β-lactamase-1 and Oxacillinase type-181 carbapenemases, which are relatively uncommon in North America and were presumably acquired in Bangladesh. Herein, we explore challenges associated with management of carbapenem-resistant Enterobacteriaceae infections, including limited available data on effective antimicrobial therapy. Read More
Pediatr Transplant 2018 11 16;22(7):e13270. Epub 2018 Jul 16.
Division of Oncology, Section of Cellular Therapy & Transplant, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Pulmonary mucormycosis diagnosed immediately after hematopoietic stem cell transplantation frequently portends a poor prognosis. However, here we describe two cases in children that were treated successfully to highlight the efficacy of a multidisciplinary approach. Despite diagnosis in the immediate post-transplant period and requirement for ongoing immunosuppression to prevent or treat GVHD, both are long-term survivors due to early surgical debridement with transfusion support and prompt initiation of targeted antifungal therapy. Read More
BMJ Case Rep 2018 Jul 15;2018. Epub 2018 Jul 15.
Department of Neurosurgery, University Hospital of Wales, Cardiff, UK.
A 75-year-old man with type 2 diabetes mellitus presented with complete loss of vision in his right eye and severe headaches for the past 24 hours. He had been treated for suspected giant cell arteritis (GCA) with high-dose corticosteroids which were being tapered to stop after an inconclusive right temporal artery biopsy and an erythrocyte sedimentation rate (ESR) value of 8. His current acute presentation, however, raised further concern for partially treated GCA and precipitated treatment with pulsed methylprednisolone. Read More
Neuropathology 2018 Oct 4;38(5):539-541. Epub 2018 Jul 4.
Department of Imaging/Neuroradiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Intracranial invasion by Mucormycosis carries high mortality mostly related to arterial occlusion and ischemic necrosis. We report clinical, imaging and autopsy findings in an adult immunodeficiency syndrome (AIDS) patient with fungal infection extending from a tooth. We report a striking discordance between a restriction of fungal growth to the initial branches of the circle of Willis and extensive ischemic infarcts of deep brain structures. Read More
Rev Soc Bras Med Trop 2018 May-Jun;51(3):401-402
Radiologia, Hospital Guilherme Álvaro, Santos, SP, Brasil.
We report the case of a 23-year-old immunocompetent patient who presented at the emergency department of a Brazilian hospital with epigastric pain and fever. After an investigation that included a computed tomography scan and upper gastrointestinal endoscopy with biopsy, a diagnosis of mucormycosis was established. The patient exhibited favorable progress after surgery and antifungal therapy. Read More
Medicine (Baltimore) 2018 Jun;97(25):e11141
Department of Dermatology.
Rationale: Cutaneous mucormycosis is an uncommon disease and occurs rarely in immunocompetent patients.
Patient Concerns: We reported the case of a 37-year-old man presenting with a skin lesion on the left side of the chest wall with no history of trauma or primary diseases. He was firstly misdiagnosed as tuberculosis and the proper treatment was thus delayed. Read More
Mycoses 2018 Oct 2;61(10):764-769. Epub 2018 Jul 2.
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
Inadequate data are available on the global epidemiology of mucormycosis, mainly derived from the evaluation of specific population groups. Rhinocerebral mucormycosis is an invading and fatal mycosis, particularly among diabetic patients. In the present study, patients hospitalised in Imam Reza Hospital in Tabriz, from 2007 to 2017, were evaluated. Read More
Paediatr Int Child Health 2018 05 24;38(2):81-84. Epub 2018 Apr 24.
b Division of Infectious Diseases , Mayo Clinic , Phoenix , AZ , USA.
Pediatr Dermatol 2018 Jul 30;35(4):e248-e250. Epub 2018 May 30.
Department of Pediatrics, Uniformed Services University, Bethesda, MD, USA.
A 7-week-old girl, born at 30 weeks' gestational age, presented to clinic for evaluation of a crop of vesicular lesions that were noted after removal of a bandage that had been in place for 4 days. A punch biopsy of the lesion revealed fungal elements that were later identified as Rhizopus spp. The lesion began to self-resolve, and no further treatment was needed, with full resolution of the lesion by 1 month after presentation. Read More
Indian Pediatr 2018 May;55(5):427-428
Department of Pathology, Institute of Child Health and Hospital for Children, Egmore, Chennai, India.
Background: Mucormycosis of the gastrointestinal tract is a rare fungal infection of neonates.
Case Characteristics: 48-hours-old term neonate presented with intestinal obstruction and perforation. No significant risk factors were present. Read More
J Mycol Med 2018 Sep 26;28(3):527-530. Epub 2018 May 26.
Department of Medical Mycology, School of Medicine/Invasive Fungi Research Center (IFRC), Mazandaran University of Medical Sciences, Sari, Iran. Electronic address:
The patients with hematologic malignancies and hematopoietic stem cell transplantation (HSCT) recipients are at high risk for invasive fungal diseases (IFDs) mainly due to the severe and prolonged neutropenia related to high-dose chemotherapy. Voriconazole prophylaxis is recommended for possible IFDs. Mucormycosis is a fulminant infection, which may occur after voriconazole prophylaxis for invasive aspergillosis in immunocompromised hosts. Read More
Rev Med Chil 2018 Jan;146(1):107-110
Unidad de Melanoma y Cáncer de Piel, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Trichodysplasia spinulosa is a rare disease that occurs in the setting of immunosuppression, associated with tolerogenic therapy used in allograft recipients or patients with hematologic malignancies. Clinically, it is characterized by a centrofacial cutaneous eruption of erythematous papules with a central keratinous spicule, often associated with variable degrees of alopecia. Histologic findings are characteristic, and electron microscopy reveals the presence of trichodysplasia spinulosa associated polyomavirus. Read More
Mycopathologia 2018 May 22. Epub 2018 May 22.
Laboratory of Veterinary Pathology, Obihiro University of Agriculture and Veterinary Medicine, W2-11, Inada, Obihiro, Hokkaido, 080-8555, Japan.
A 4-year-old captive ringed seal (Pusa hispida) was treated with subcutaneous antibacterial injections for pus exuding wounds in the skin and associated blubber following a bite attack. Three months after the incident, the animal presented nystagmus and died the following day. At necropsy, there was a 25 × 18 × 25 mm well-delineated, opaque nodular mass in the lung, besides the skin ulcers and localized areas of discoloration in the blubber correlating with the bite wound and injection sites. Read More
Rev Mal Respir 2018 Apr 10;35(4):452-464. Epub 2018 May 10.
Service d'hématologie clinique, hôpital François-Mitterrand, CHU de Dijon, 14, rue Gaffarel, 21079 Dijon cedex, France; Inserm unité 866, LabEx Team, faculté de médecine, 21079 Dijon, France.
Introduction: In acute leukaemia (AL), the occurrence of pulmonary mucormycosis (PM), the incidence of which is increasing, as a result of chemotherapy induced marrow aplasia, remains a life threatening complication.
Methods: Analysis of clinical, biological and thoracic CT characteristics of patients with PM developing during the treatment of AL between 2000 and 2015. Day 0 (D0) was defined as the day with first CT evidence of PM. Read More
Drug Des Devel Ther 2018 30;12:1033-1044. Epub 2018 Apr 30.
Department of Medicine, University of California San Diego, San Diego, CA, USA.
In recent decades, important advances have been made in the diagnosis and treatment of invasive aspergillosis (IA) and mucormycosis. One of these advances has been the introduction of isavuconazole, a second-generation broad spectrum triazole with a favorable pharmacokinetic and safety profile and few drug-drug interactions. Phase III trials in patients with IA and mucormycosis demonstrated that isavuconazole has similar efficacy to voriconazole for the treatment of IA (SECURE trial) and liposomal amphotericin B for the treatment of mucormycosis (VITAL trial with subsequent case-control analysis) and a favorable safety profile with significantly fewer ocular, hepatobiliary, and skin and soft tissue adverse events compared to voriconazole. Read More
Infection 2018 Aug 10;46(4):503-512. Epub 2018 May 10.
Department of Respiratory Medicine, Peking Union Medical College Hospital, Beijing, China.
Purpose: Little is known about risk factors for the outcome of pulmonary mucormycosis. We summarized characteristics of this rare disease, and systemically explored risk factors for the outcome.
Methods: Ninety-two patients with pulmonary mucormycosis, including 12 patients at Peking Union Medical College Hospital and 80 patients published in 62 articles between 2006 and 2016, were retrospectively analyzed. Read More
Indian J Med Microbiol 2018 Jan-Mar;36(1):136-139
Department of Medical Microbiology, Sepsis Research Group, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
The Conidiobolus coronatus-related rhinoentomophthoromycosis in immunocompetent and immunocompromised (HIV negative) individuals has been treated successfully with antifungal drugs. However, C. coronatus infections in first-line antiretroviral therapy (ART)-resistant (HIV infected) individuals particularly with rhinoentomophthoromycosis have not been reported previously. Read More
Am J Case Rep 2018 May 4;19:527-533. Epub 2018 May 4.
Department of Pathology, Al-Amiri Hospital, Kuwait City, Kuwait.
BACKGROUND Spontaneous gastric perforation is usually a complication of peptic ulcer disease, or a postoperative complication resulting from gastric torsion. Mucormycosis (or zygomycosis) is an uncommon opportunistic fungal infection that is usually seen in immunocompromised patients and is associated with significant morbidity and mortality. This report is of a rare case of spontaneous gastric perforation due to mucormycosis infection. Read More
J Clin Exp Dent 2018 Mar 1;10(3):e300-e305. Epub 2018 Mar 1.
Post-graduate student, Department of Prosthodontics, School of Dental Sciences, KIMSDU, Karad, Maharashtra, India.
Mucormycosis is a rare, fulminant, rapidly spreading fungal infection, which usually affects patient with underlying immune deficiency. If not managed promptly, the disease is characterized by progressive necrosis and is often fatal. A review of English literature shows that only fourteen cases of mucormycosis have been reported after tooth extraction. Read More
J Pediatr Endocrinol Metab 2018 Jun;31(6):689-692
Division of Endocrinology and Diabetes, Medanta Medicity Hospital, Gurugram (Haryana), India.
Background: Mucormycosis is a potentially fatal complication of diabetes. The rhino-orbito-cerebral form is the most common presentation, however, rarely other types can also be seen.
Case Presentation: We describe the case of a 4½ -year-old boy not previously known to be a diabetic who presented to the plastic surgery department for gangrene of the left middle finger with surrounding erythema and induration. Read More
Biomedica 2018 Mar 15;38(1):27-31. Epub 2018 Mar 15.
Departamento de Anatomía Patológica y Patología Clínica, Universidad del Valle, Cali, Colombia.
Rhino-orbito-cerebral mucormycosis from dental origin is an acute infection caused by opportunistic fungi belonging to the order of Mucorales, which affects mainly diabetic and immunocompromised patients.We report the case of a 63-year old diabetic man who performed a dental extraction on himself by his own means and subsequently developed a rhino-orbito-cerebral mucormycosis with cutaneous and palatal affection. The species isolated in the mycological culture was Rhizopus sp. Read More
BMJ Case Rep 2018 Apr 17;2018. Epub 2018 Apr 17.
Department of Otolaryngology, Academic Medical Centre, Amsterdam, The Netherlands.
In this report, we describe the case of a young, diabetic girl with ketoacidosis who suffered sudden loss of vision of the right eye. The loss of vision was caused by an invasive rhino-orbital-cerebral fungal infection (mucormycosis) with extensive periorbital thrombosis. Despite maximal antifungal and surgical treatment (including exenteration of the right orbit), the clinical situation deteriorated. Read More
Heart Surg Forum 2018 03 5;21(2):E072-E074. Epub 2018 Mar 5.
Department of Cardiovascular and Thoracic Surgery, Mayo Clinic, Scottsdale, Arizona, USA.
Invasive mucormycosis infections occur in less than 1% of recipients of orthotopic heart transplants. Given the angioinvasive nature of these infections, the mortality rate is high. Little literature exists regarding the presentation and management of these infections. Read More
J Clin Orthop Trauma 2018 Mar 16;9(Suppl 1):S10-S14. Epub 2017 Oct 16.
Department of Orthopaedics, Sri Ramachandra University, India.
Zygomycosis is the third leading cause of invasive fungal infection after candidiasis and aspergillosis. Although zygomycosis mostly affects immunocompromised individuals trauma may potentiate infection in immunocompetent individuals. The mortality rate of Zygomycosis is around 50% due to angioinvasion. Read More
QJM 2018 Jul;111(7):499-500
From the Infectious Diseases Department.
Transplant Proc 2018 Apr 22;50(3):905-909. Epub 2018 Mar 22.
Nephrology Dialysis and Transplant Unit, University of Modena and Reggio Emilia, AOU Policlinico of Modena, Modena, Italy.
Mucormycosis is an uncommonly encountered fungal infection in solid organ transplantation. The infection is severe and often results in a fatal outcome. The most common presentations are rhino-sino-orbital and pulmonary disease. Read More
BMJ Case Rep 2018 Mar 22;2018. Epub 2018 Mar 22.
ENT, Kasturba Medical College, Manipal, India.
Entomopthoromycosis is a rare subcutaneous fungal infection caused by affecting mainly the upper respiratory mucosa in immunocompetent people.The manifestations of this disease masquerades other clinical entities.Hence, high index of suspicion is required for prompt diagnosis. Read More
Pediatr Transplant 2018 06 23;22(4):e13172. Epub 2018 Mar 23.
Division of Nephrology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada.
Mucormycosis is a rare and potentially life-threatening infection, typically affecting immunocompromised hosts. We report a case of an adolescent boy who developed primary isolated cutaneous mucormycosis in the early period following kidney transplantation. Surgical excision was performed using intraoperative fungal staining to obtain clear margins, followed by topical and systemic antifungal therapy. Read More
Indian J Pathol Microbiol 2018 Jan-Mar;61(1):103-105
Department of Pathology, Armed Forces Medical College, Pune, Maharashtra, India.
Mucormycosis is a relatively rare fungal infection seen in immunocompromised patients. Very few cases of invasive cutaneous mucormycosis occurring in neonates have been reported in literature. It is an aggressive disease with a mortality rate of around 64% in neonates, so a high index of suspicion is essential for rapid diagnosis and definitive treatment with broad-spectrum antifungals such as Amphotericin B. Read More
Acta Gastroenterol Belg 2017 Oct-Dec;80(4):553-554
Department of Medicine, Elmhurst Hospital Center, NY, USA.
Intern Emerg Med 2018 08 20;13(5):795-796. Epub 2018 Mar 20.
Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Cheng-Kung Road, Neihu District, Taipei, 11490, Taiwan.
Med Mycol 2018 Apr;56(suppl_1):93-101
School of Medicine, European University of Cyprus.
The diagnosis and treatment of mucormycosis are challenging. The incidence of the disease seems to be increasing. Hematological malignancies are the most common underlying disease in countries with high income and uncontrolled diabetes in developing countries. Read More
Intern Med 2018 Aug 9;57(16):2421-2424. Epub 2018 Mar 9.
Department of Infection Control Center, Osaka Police Hospital, Japan.
A 53-year-old woman was hospitalized due to septic shock after developing pneumococcal pneumonia after undergoing esophageal cancer surgery. Her transverse colon became perforated after receiving antimicrobial chemotherapy; therefore, emergency subtotal colectomy was performed. Fungi detected in both her colon tissue and a drainage sample indicated intestinal mucormycosis. Read More
J Pediatric Infect Dis Soc 2018 Aug;7(3):e169-e171
Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri.
An 11-year-old immunocompetent girl presented with two and a half months of progressive right orbital cellulitis, which did not respond to multiple courses of antibiotics or prednisone. A panfungal polymerase chain reaction primer was positive for Saksenaea vasiformis, and she completed 5 months of oral posaconazole therapy after debridement. Saksenaea vasiformis is a rare cause of zygomycosis, and it typically causes skin and soft tissue infection in immunocompetent hosts, particularly after a traumatic injury. Read More
J Oral Maxillofac Pathol 2018 Jan;22(Suppl 1):S112-S116
Department of Oral Pathology and Microbiology, V S Dental College and Hospital, Bengaluru, Karnataka, India.
Mucormycosis or zygomycosis, also called phycomycosis, is an uncommon, invasive, potentially lethal and an aggressive fungal infection of the order that usually affects patients with alteration of their immunological system. From its initial description (Paltauf, 1885), this entity still has a high mortality. Imaging techniques are not usually diagnostic, and cultures are not totally reliable. Read More