5,286 results match your criteria Zygomycosis


COVID-19 associated mucormycosis in Assiut University Hospitals: a multidisciplinary dilemma.

Sci Rep 2022 Jun 21;12(1):10494. Epub 2022 Jun 21.

Department of Internal Medicine and Critical Care, Faculty of Medicine, Assuit University, Assiut, 71515, Egypt.

Mucormycosis is a life-threatening opportunistic angioinvasive fungal infection. We aimed to describe the frequency, presentations, predictors, and in-hospital outcome of mucormycosis patients in the scope of CoronaVirusDisease-19 (COVID-19) during the third viral pandemic wave. This cross-sectional retrospective study included all patients who fulfilled the criteria of mucormycosis with concurrent confirmed covid19 infection admitted to Assuit University Hospital between March 2021 and July 2021. Read More

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Serum glucose-regulated protein 78 (GRP78) levels in COVID-19-associated mucormycosis: results of a case-control study.

Mycopathologia 2022 Jun 21. Epub 2022 Jun 21.

Department of Pulmonary Medicine, Post Graduate Institute of Medical Education and Research (PGIMER), Sector-12, Chandigarh, 160012, India.

Background: In experimental models, the expression of glucose-regulated protein 78 (GRP78) in endothelial cells played a role in the pathogenesis of mucormycosis. However, the role of GRP78 in COVID-19-associated mucormycosis (CAM) has not been studied. We hypothesized that serum GRP78 levels are elevated in subjects with CAM. Read More

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Could cattle dung burning have contributed to the epidemic of COVID-19-associated mucormycosis in India? Results of an experimental aero-mycological study.

Mycoses 2022 Jun 20. Epub 2022 Jun 20.

Department of Pulmonary Medicine, Postgraduate institute of medical education and Research, Chandigarh, India.

Background: Several hypotheses have been proposed for explaining the outbreak of coronavirus disease 2019 (COVID-19)-associated mucormycosis in India, including the burning of cattle dung cakes, though no study has yet been conducted to support this claim.

Methods: We conducted an aero-mycological study to evaluate whether Mucorales in the air increased during or after burning cattle dung cakes. We further compared the growth of Mucorales in the indoor air samples from houses with and without cattle. Read More

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Immunoinformatic Design of a Multivalent Peptide Vaccine Against Mucormycosis: Targeting FTR1 Protein of Major Causative Fungi.

Front Immunol 2022 26;13:863234. Epub 2022 May 26.

Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.

Mucormycosis is a potentially fatal illness that arises in immunocompromised people due to diabetic ketoacidosis, neutropenia, organ transplantation, and elevated serum levels of accessible iron. The sudden spread of mucormycosis in COVID-19 patients engendered massive concern worldwide. Comorbidities including diabetes, cancer, steroid-based medications, long-term ventilation, and increased ferritin serum concentration in COVID-19 patients trigger favorable fungi growth that in turn effectuate mucormycosis. Read More

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Case Report: Immune Checkpoint Blockade Plus Interferon-Γ Add-On Antifungal Therapy in the Treatment of Refractory Covid-Associated Pulmonary Aspergillosis and Cerebral Mucormycosis.

Front Immunol 2022 1;13:900522. Epub 2022 Jun 1.

Centre for Infectious Diseases and Tropical Medicine, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique -Hôpitaux de Paris, Université de Paris, Paris, France.

Invasive fungal diseases (IFD) still cause substantial morbidity and mortality, and new therapeutic approaches are urgently needed. Recent data suggest a benefit of checkpoint inhibitors (ICI). We report the case of a diabetic patient with refractory IFD following a SARSCoV-2 infection treated by ICI and interferon-gamma associated with antifungal treatment. Read More

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Mucormycosis - A growing concern in this pandemic?

J Pak Med Assoc 2022 05;72(5):1017

4th Year MBBS Student, Dow University of Health Sciences, Karachi, Pakistan.

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Evaluation and Comparison of Mucormycosis Patients' Features Undergoing Functional Endoscopic Sinus Surgery Prior to and during the COVID-19 Pandemic: A Case-Control Study.

Int J Clin Pract 2022 7;2022:1248325. Epub 2022 Jun 7.

Anesthesiology and Critical Care Research Center, Department of Anesthesiology and Critical Care, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Rhinocerebral mucormycosis is a serious invasive fungal infection that is one of the most aggressive and lethal of invasive mycoses. The coronavirus disease (COVID-19) has been linked to immune dysregulation, and patients with COVID-19 have been reported to be at risk for developing invasive fungal infections. This study is conducted to evaluate the concurrence of mucormycosis among COVID-19 patients. Read More

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Clinical Manifestations of Pulmonary Mucormycosis in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation: A 21-Case Series Report and Literature Review.

Can Respir J 2022 2;2022:1237125. Epub 2022 Jun 2.

Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing 100044, China.

Introduction: Mucormycosis is a rare, invasive disease caused by opportunistic pathogens related to the Mucorales order with high fatality rates in immunocompromised hosts, especially in recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Diagnosis and treatment of pulmonary mucormycosis in recipients of allo-HSCT remains challenging.

Purpose: The aim of this study is to summarize and analyze the clinical features of pulmonary mucormycosis in recipients of allo-HSCT to explore further clinical research directions for this rare fungal infection in the particular populations. Read More

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[Clinical features of children with spp. infection: a case report and literature review].

Nan Fang Yi Ke Da Xue Xue Bao 2022 May;42(5):780-784

Department of Pediatrics, Second Xiangya Hospital of Central South University, Changsha 410011, China.

We report a case of mucormycosis induced by spp. infection in a ten-year-old girl with acute lymphoblastic leukemia, who developed fever and respiratory symptoms after chemotherapy and was diagnosed with invasive fungal disease. Peripheral blood DNA sequences were analyzed using metagenomic next-generation sequencing (mNGS), and by comparison with the Pathogens Metagenomics Database (PMDB), we identified spp. Read More

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[Disseminated mucormycosis after allogeneic hematopoietic stem cell transplantation in a child].

Zhonghua Er Ke Za Zhi 2022 Jun;60(6):598-599

Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

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Commentary : Combating COVID-19-associated mucormycosis with limited resources.

Indian J Ophthalmol 2022 Jun;70(6):2169

Department of Orbit, Oculoplasty, Ocular Oncology and Ocular Prosthesis, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Madurai, Tamil Nadu, India.

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Analysis of COVID-19-associated rhino-orbital-cerebral mucormycosis patients in a tertiary care center in Northern India.

Indian J Ophthalmol 2022 Jun;70(6):2163-2168

Department of Ophthalmology, Sarojini Naidu Medical College, Agra, Uttar Pradesh, India.

Purpose: An unprecedented surge has been noted in rhino-orbital-Cerebral mucormycosis (ROCM) in times of current COVID-19 pandemic. The present prospective study aims to evaluate clinico-epidemiological profile, risk factors, management, and outcome of the cases of ROCM that presented to our tertiary care center during the study period from April to June 2021.

Methods: All patients were subjected to complete history taking, ophthalmological examination, and imaging studies. Read More

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Knowledge, attitude, and practice toward mucormycosis among patients presenting to six tertiary eye care hospitals in South India - A multicentric online questionnaire-based survey.

Indian J Ophthalmol 2022 Jun;70(6):2158-2162

Project Manager, Aravind Eye Hospital, Pondicherry, India.

Purpose: To study the awareness on mucormycosis among outpatients who visited six tertiary eye care hospitals at Madurai, Pondicherry, Coimbatore, Tirunelveli, Chennai, and Tirupati.

Methods: This was a telephone-based survey conducted using questionnaires consisting of 38 questions in five sections from July 5 to 25, 2021. Patients visiting the eye hospitals for an examination were contacted over their phones and responses were directly entered onto the Google forms platform. Read More

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Batwing incision for a case of bilateral fungal zygomatic osteomyelitis.

BMJ Case Rep 2022 May 31;15(5). Epub 2022 May 31.

ENT & head and neck surgery, All India Institute of Medical Sciences, New Delhi, India

Zygomatic osteomyelitis is a rare occurrence due to rich collateral blood supply of bone. A man in his 30s presented with complaints of pain over bilateral cheek and pus discharge below the eye on lateral aspect. He was a known case of COVID-19 associated mucormycosis postendoscopic debridement of sinuses 3 months back. Read More

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Early suspicion can save lives; mucormycosis in two children with diabetic ketoacidosis in Pakistan.

J Pak Med Assoc 2022 Apr;72(4):790-792

National Institute of Child Health, Karachi Pakistan.

Mucormycosis is a cause of fulminant necrotising fungal infection in children with underlying immunocompromising conditions. Rhino-orbito-cerebral infection is its most common form in the paediatric group with uncontrolled diabetes mellitus or diabetic ketoacidosis. The initial presentation can mimic a bacterial infection; thus a high index of suspicion is needed for timely intervention to reduce morbidity and mortality. Read More

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COVID-19 and Mucormycosis in India a Study on Implicated Risk Factors.

J Assoc Physicians India 2022 05;70(5):11-12

Post Graduate in Internal Medicine, Gandhi Medical College, Secunderabad, Telangana.

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The Past, Present and Future of COVID-19 Associated Mucormycosis: A Rapid Review.

J Prim Care Community Health 2022 Jan-Dec;13:21501319221099476

Universidad Espíritu Santo, Samborondón, Ecuador.

Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, which is known for the multiple mutations and forms that have rapidly spread across the world. With the imminent challenges faced by low- and middle-income countries in curbing the public health fallbacks due to limited resources, mucormycosis emerged as a fungal infection associated with high mortality. In this rapid review, we explored MEDLINE, Cochrane, Web of Science, WHO Global Database, and the search engine-Google Scholar for articles listed until July 2021 and presented a narrative synthesis of findings from 39 articles. Read More

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MR imaging spectrum in COVID associated Rhino-Orbito-Cerebral mucormycosis with special emphasis on intracranial disease and impact on patient prognosis.

Eur J Radiol 2022 Jul 6;152:110341. Epub 2022 May 6.

Department of Ophthalmology, Maulana Azad Medical College and Guru Nanak Eye Centre, New Delhi 110002, India.

In the wake of the ongoing Coronavirus Disease 2019 (COVID-19) pandemic, a new epidemic of COVID associated mucormycosis (CAM) emerged in India. Early diagnosis and prompt treatment of this deadly disease are of paramount importance in improving patient survival. MRI is the cornerstone of diagnosis of early extrasinus disease, particularly intracranial complications which have traditionally been associated with a high mortality rate. Read More

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Aspergillosis and Mucormycosis in COVID-19 Patients: A Systematic Review.

J Coll Physicians Surg Pak 2022 May;32(5):639-645

Community Medicine, King Edward Medical University, Lahore, Pakistan.

Fungal infections have increased in number since the onset of this lethal pandemic. This study aimed to assess risk factors and case fatality in COVID-19 cases with aspergillosis or mucormycosis. A systematic review was done according to PRISMA guidelines. Read More

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Desensitization to liposomal amphotericin B after anaphylaxis in a patient with COVID-19-associated mucormycosis - A case with review of literature.

Indian J Pharmacol 2022 Mar-Apr;54(2):150-152

Department of Anaesthesia and Critical Care, All India Institute of Medical Sciences, New Delhi, India.

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Sinonasal mucormycosis and liposomal amphotericin B: A quest for dose optimization.

Indian J Pharmacol 2022 Mar-Apr;54(2):90-96

Department of Otorhinolaryngology and Head-Neck Surgery, All India Institute of Medical Sciences, New Delhi, India.

Objectives: Sinonasal mucormycosis is a serious fungal infection. Early diagnosis and prompt antifungal therapy along with surgical intervention is the key to its management. Liposomal amphotericin B (LAmB) given intravenously is the antifungal agent of choice. Read More

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Mucormycosis: time to address this deadly fungal infection.

Lancet Microbe 2021 08 14;2(8):e343-e344. Epub 2021 Jun 14.

Division of Infectious Diseases, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.

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COVID-19-Associated Mucormycosis: An Opportunistic Fungal Infection. A Case Series and Review.

Int J Infect Dis 2022 Aug 6;121:203-210. Epub 2022 May 6.

Ear, Nose and Throat Surgical Department, Sohar Hospital, Ministry of Health, Sohar, Oman.

Background: A surge in COVID-19-associated mucormycosis cases has been observed during the second wave of COVID-19 in summer of 2021. Most cases were reported from India. The Delta variant (B. Read More

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Coronavirus Disease 2019-associated mucormycosis and cytomegalovirus coinfection in a kidney transplant recipient.

Saudi J Kidney Dis Transpl 2021 Sep-Oct;32(5):1501-1504

Department of Nephrology and Renal Transplantation, Virinchi Hospitals, Hyderabad, Telangana, India.

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Paediatric cutaneous mucormycosis: A case report and review of the literature.

Mycoses 2022 Jul 24;65(7):674-682. Epub 2022 May 24.

Infectious Diseases Unit, 3rd Department of Pediatrics, School of Medicine, Aristotle University, Thessaloniki, Greece.

Background: Mucormycosis has emerged as an increasingly important fungal disease for immunocompromised children and neonates, with the cutaneous form being one of its most common presentations.

Methods: We present a cutaneous mucormycosis case in a 10-year-old girl and analyse reports of single cases and case series of cutaneous mucormycosis in ≤16-year-old patients, recorded in PUBMED from 1953 to 2020, for epidemiology, risk factors, diagnostic and therapeutic procedures and outcome.

Results: 113 cases were enrolled. Read More

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Dual targeting of RdRps of SARS-CoV-2 and the mucormycosis-causing fungus: an perspective.

Authors:
Abdo A Elfiky

Future Microbiol 2022 07 5;17:755-762. Epub 2022 May 5.

Biophysics Department, Faculty of Sciences, Cairo University, Giza, 12613, Egypt.

During the past few months, mucormycosis has been associated with SARS-CoV-2 infections. Molecular docking combined with molecular dynamics simulation is utilized to test nucleotide-based inhibitors against the RdRps of SARS-CoV-2 solved structure and RdRp model built . The results reveal a comparable binding affinity of sofosbuvir, galidesivir, ribavirin and remdesivir compared with the physiological nucleotide triphosphates against RdRp as well as the SARS-CoV-2 RdRp as reported before. Read More

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Bilateral blindness in a young male of rhino-orbital-cerebral mucormycosis: A case report.

Indian J Ophthalmol 2022 05;70(5):1822-1824

Department of Radio-Diagnosis, Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India.

The storm of COVID-19-associated mucormycosis (CAM) has not yet settled, and it has proven itself a disfiguring and potentially life-threatening disease, complicating the course of COVID-19 infection. Mucormycosis is a rare but devastating fungal infection caused by filamentous fungi of the family Mucoraceae. We report a rare case of a 37-year-old diabetic male with bilateral rhino-orbital-cerebral mucormycosis (ROCM) where it leads to bilateral central retinal artery occlusion (CRAO) as manifestation of the disease. Read More

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Twitter sentiment analysis for COVID-19 associated mucormycosis.

Indian J Ophthalmol 2022 05;70(5):1773-1779

Principal Scientist, CSIR-Central Scientific Instruments Organisation, Chandigarh; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India.

Purpose: COVID-19-associated mucormycosis (CAM) was a serious public health problem during the second wave of COVID-19 in India. We planned to analyze public perceptions by sentiment analysis of Twitter data regarding CAM.

Methods: In this observational study, the application programming interface (API) provided by the Twitter platform was used for extracting real-time conversations by using keywords related to mucormycosis (colloquially known as "black fungus"), from May 3 to August 29, 2021. Read More

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Analysis of COVID-19 publications in the during two years of the pandemic and their impact on ophthalmic literature.

Indian J Ophthalmol 2022 05;70(5):1522-1532

Cataract, Pediatric Ophthalmology and Squint Services, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Pondicherry, India.

Purpose: To perform a comprehensive analysis of COVID-19 publications published in the Indian Journal of Ophthalmology (IJO) during the two years of the pandemic and to study their impact on ophthalmic literature.

Methods: : A retrospective analysis was performed of all expedited COVID-19 articles published in IJO from April 2020 to March 2022. The data was obtained from the official website of IJO, editor IJO monthly emails, and PubMed database. Read More

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