4,386 results match your criteria Zygomycosis


Pulmonary Mucormycosis (Zygomycosis) Presenting as an Infective Exacerbation of Chronic Obstructive Pulmonary Disease.

Eur J Case Rep Intern Med 2018 27;5(12):000995. Epub 2018 Dec 27.

Department of Respiratory Medicine, Nicosia General Hospital, Cyprus.

Mucormycosis is a life-threatening fungal infection whose incidence has been rising recently, mainly due to the increasing use of immunosuppressive and corticosteroid treatment. In previous decades, mucormycosis was associated with a very poor prognosis as mortality was approximately 100%. Mortality rates reported in recent literature have only slightly improved despite the availability of targeted therapy with amphotericin B. Read More

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http://dx.doi.org/10.12890/2018_000995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346968PMC
December 2018
1 Read

Gastrointestinal mucormycosis in a child with acute lymphoblastic leukemia: An uncommon but ominous complication.

Indian J Cancer 2018 Jul-Sep;55(3):304-305

Department of Medical Oncology, Cancer Institute (WIA), Chennai, Tamil Nadu, India.

Invasive fungal infections constitute a major cause of morbidity and mortality in children undergoing therapy for hematological malignancies. We report a 1-year-old boy who was receiving chemotherapy for acute lymphoblastic leukemia. His clinical course was complicated by a clinical syndrome consistent with neutropenic enterocolitis to which he succumbed. Read More

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http://dx.doi.org/10.4103/ijc.IJC_260_18DOI Listing
January 2019
2 Reads

Neonatal Acute Liver Failure Associated with Angioinvasive Hepatic Zygomycosis.

Fetal Pediatr Pathol 2018 Dec 31:1-8. Epub 2018 Dec 31.

a Department of Histopathology , Post Graduate Institute of Medical Education and Research , Chandigarh , India.

Background: Neonatal acute liver failure (NALF) is often a fatal condition. Zygomycosis is a fungal infection that is often fatal in both adults and infants. Only a few cases of hepatic zygomycosis are reported in the literature and they are invariably associated with immunosuppression. Read More

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http://dx.doi.org/10.1080/15513815.2018.1556368DOI Listing
December 2018
2 Reads
0.398 Impact Factor

Rhinocerebral mucormycosis after functional endoscopic sinus surgery: A case report.

Medicine (Baltimore) 2018 Dec;97(51):e13290

Department of Otolaryngology-Head and Neck Surgery.

Rationale: Mucormycosis is a rare fungal infection which mainly develops in compromised hosts and the associated mortality rate is high.

Patient Concerns: We report a case of mucormycosis in a 59-year-old woman following routine endoscopic sinus surgery. The patient had a history of diabetes mellitus (DM) and bronchial asthma. Read More

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http://dx.doi.org/10.1097/MD.0000000000013290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319933PMC
December 2018
8 Reads

Mycotic Rhinitis and Sinusitis in Florida Horses.

Vet Pathol 2018 Dec 17:300985818817046. Epub 2018 Dec 17.

1 Department of Comparative, Diagnostic and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.

Rhinitis and sinusitis caused by fungal pathogens were studied in biopsy samples submitted from 52 horses distributed throughout subtropical and tropical regions of Florida. Methods included routine histopathology as well as polymerase chain reaction (PCR) with panfungal/panoomycete primers and DNA sequencing on extracted DNA (DNA barcoding). Granulomatous, pyogranulomatous, and fibrinopurulent lesions in nasal and sinus mucosa were associated with signs of upper airway obstruction and noise as well as nasal discharge. Read More

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http://dx.doi.org/10.1177/0300985818817046DOI Listing
December 2018

An Unusual Case of Pulmonary Mucormycosis.

Transplant Proc 2018 Dec 6;50(10):3943-3945. Epub 2018 Jun 6.

Alice Springs Hospital, Northern Territory, Australia.

Invasive fungal infections in solid organ transplant recipients are associated with significant morbidity and mortality. Of these fungal infections, mucormycosis presents as an aggressive, frequently fatal angioinvasive infection. Immunocompromised hosts and diabetes are important risk factors. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.06.001DOI Listing
December 2018

Zygomycosis due to Mucor racemosus Associated with a Circovirus Infection in a Blue Tit (Cyanistes caeruleus).

J Comp Pathol 2018 Nov 1;165:67-71. Epub 2018 Nov 1.

Centre for Clinical Veterinary Medicine, Clinic for Birds, Small Mammals, Reptiles and Ornamental Fish, Ludwig-Maximilians-Universität München, Sonnenstrasse 18, Oberschleißheim, Germany.

In spring 2014, several wild passeriform garden birds were found severely ill or dead, all with severe periocular swellings. A blue tit (Cyanistes caeruleus) showing severe depression was humanely destroyed and sent for necropsy examination. In this bird, the lower eyelids were sagging, red and oedematous. Read More

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http://dx.doi.org/10.1016/j.jcpa.2018.09.011DOI Listing
November 2018
1 Read

[The treatment of mucormycosis (zygomycosis) in the 21st century].

Rev Iberoam Micol 2018 Oct - Dec;35(4):217-221. Epub 2018 Nov 22.

Unidad de Enfermedades Infecciosas, Hospital Universitario y Politécnico La Fe, Valencia, España. Electronic address:

Infections due to zygomycetes, caused by mucorales and entomophthorales, are characterized by angioinvasion and invasion of neighboring organs or structures. Mucorales most commonly cause rhinocerebral, pulmonary, cutaneous or disseminated infection and its spread is favored by several diseases (such as diabetes or chronic kidney disease) and risk factors (neutropenia, immunosuppression, iron overload). They have a high mortality rate, and the key to success in their treatment are early diagnosis, prompt administration of antifungal treatment, and extensive surgical debridement. Read More

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http://dx.doi.org/10.1016/j.riam.2018.09.001DOI Listing
November 2018
6 Reads

Pathways of Pathogenicity: Transcriptional Stages of Germination in the Fatal Fungal Pathogen .

mSphere 2018 09 26;3(5). Epub 2018 Sep 26.

Institute for Microbiology and Infection, School of Biosciences, University of Birmingham, Birmingham, United Kingdom

is an invasive fungal pathogen responsible for the frequently fatal disease mucormycosis. Germination, a crucial mechanism by which infectious spores of cause disease, is a key developmental process that transforms the dormant spore state into a vegetative one. The molecular mechanisms that underpin this transformation may be key to controlling mucormycosis; however, the regulation of germination remains poorly understood. Read More

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http://dx.doi.org/10.1128/mSphere.00403-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158513PMC
September 2018
9 Reads

Necrotizing fungal infection due to : A case report and review of literature.

Indian J Ophthalmol 2018 Oct;66(10):1513-1516

Department of Orbit, Oculoplasty, Reconstructive and Aesthetics, Medical Research Foundation, Chennai, Tamil Nadu, India.

Mucormycosis caused by Saksenaea erythrospora is an emerging infection seen with soil contamination, burns and/or nosocomial infections. PCR amplification and internal transcribed spacer sequencing is gold standard for its identification. Here, we report a case of necrotizing fungal orbital infection by S. Read More

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http://www.ijo.in/text.asp?2018/66/10/1513/242011
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http://dx.doi.org/10.4103/ijo.IJO_389_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173015PMC
October 2018
9 Reads

Mucormycosis outbreak due to Rhizopus microsporus after arthroscopic anterior cruciate ligament reconstruction surgery evaluated by RAPD and MALDI-TOF Mass spectrometry.

J Mycol Med 2018 Dec 22;28(4):617-622. Epub 2018 Sep 22.

Laboratorio de Micología y Diagnóstico Molecular (CONICET), Cátedra de Parasitología y Micología, Facultad de Bioquímica y Ciencias Biológicas, Ciudad Universitaria, Paraje el Pozo S/N, CP 3000 Santa Fe, Argentina; Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), CCT, Santa Fe, Argentina. Electronic address:

Background: Rhizopus microsporus is one of the main causative agents of mucormycosis. These mycoses are mostly described as isolated cases involving uncontrolled diabetes mellitus or immunosuppressed patients. In this work we report a nosocomial outbreak of mucormycosis due to R. Read More

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http://dx.doi.org/10.1016/j.mycmed.2018.09.002DOI Listing
December 2018
1 Read

[Clinical high risk factors and prognosis of 25 pulmonary mucormycosis cases].

Zhonghua Yi Xue Za Zhi 2018 Aug;98(32):2579-2582

Department of Respiratory Medicine, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.

To analyze high risk factors, therapeutic regimen and prognosis of patients with pulmonary mucormycosis. A retrospective analysis was performed on the clinical data of 25 patients who were diagnosed as pulmonary mucormycosis in the First Affiliated Hospital, School of Medicine, Zhejiang University, between January 2009 and December 2017. Univariate analysis revealed that no risk factor had significant effect on prognosis of these 25 cases, while multivariate logistic regression analysis confirmed that the exposure to antifungal drugs was correlated to worse prognosis(=0. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2018.32.009DOI Listing
August 2018
17 Reads

Basidiobolomycosis in Togo: clinico-pathological study of a series of 12 presumed cases.

BMC Res Notes 2018 Sep 14;11(1):667. Epub 2018 Sep 14.

Department of Pathology, University Teaching Hospital of Lomé, Lomé, Togo.

Objective: The purpose of our study was to describe the histological diagnosed of the Basidiobolomycosis cases from 1990 to 2017 (28 years) in the only Pathology Anatomy Laboratory in Togo.

Results: A total of 12 cases of suspected Basidiobolomycosis have been identified. The sex ratio (M/F) was 2. Read More

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http://dx.doi.org/10.1186/s13104-018-3777-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137730PMC
September 2018
2 Reads

Tongue necrosis secondary to mucormycosis in a diabetic patient: A first case report in Malaysia.

J Mycol Med 2018 Sep 7;28(3):519-522. Epub 2018 Jul 7.

Department of Oral and Maxillofacial Surgery, Hospital Sungai Buloh, Selangor, Malaysia.

Mucormycosis is a rare fungal infection and high mortality that commonly affects patients with the weakened immune system. We present an unusual case of tongue necrosis probably due to the healthcare-associated mucormycosis (HCM) in a diabetic patient. Although cannot be proved with certainty, we surmise that intubation as a risk factor in our case. Read More

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http://dx.doi.org/10.1016/j.mycmed.2018.06.004DOI Listing
September 2018

Pulmonary Campylobacter concisus infection in an immunocompromised patient with underlying mucormycosis.

Int J Infect Dis 2018 Nov 8;76:45-47. Epub 2018 Sep 8.

Institute of Medical Microbiology and Hygiene, University Hospital of Ulm, Albert-Einstein-Allee 23, D-89081 Ulm, Germany.

Campylobacter concisus is a rarely encountered agent of human infection. The first isolation of C. concisus from a pulmonary abscess in an immunocompromised patient who underwent allogeneic stem cell transplantation is reported here. Read More

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http://dx.doi.org/10.1016/j.ijid.2018.08.021DOI Listing
November 2018
4 Reads

Staring at the stars: a case of gastrointestinal basidiobolomycosis from the Indian subcontinent.

BMJ Case Rep 2018 Sep 5;2018. Epub 2018 Sep 5.

Medicine, All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.1136/bcr-2018-226693DOI Listing
September 2018
2 Reads

Primary Oral Mucormycosis Due to Rhizopus microsporus after Allogeneic Stem Cell Transplantation.

Intern Med 2018 1;57(17):2567-2571. Epub 2018 Sep 1.

Department of Hematology, Nagasaki University Hospital, Japan.

We herein report a rare case of oral mucormycosis following allogeneic hematopoietic stem cell transplantation. Oral mucormycosis due to Rhizopus microsporus manifested as localized left buccal mucositis with a 1-cm black focus before neutrophil recovery. Combination therapy with liposomal amphotericin B was initiated and surgical debridement was performed; however, the patient died due to progressive generalized mucormycosis. Read More

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http://dx.doi.org/10.2169/internalmedicine.0474-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172532PMC
November 2018
2 Reads

Rhinocerebral Zygomycosis Due to a Lichtheimia ramosa Infection in a Calf: Neural Spread Through the Olfactory Nerves.

Mycopathologia 2019 Feb 30;184(1):141-146. Epub 2018 Aug 30.

Research Center for Global Agromedicine, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-11, Obihiro-Shi, Hokkaido, 080-8555, Japan.

Here, we report a case of rhinocerebral zygomycosis due to a Lichtheimia ramosa infection in a calf. A histopathological examination revealed that a fungus had invaded the brain through the olfactory nerves. Lichtheimia ramosa was detected by polymerase chain reaction analysis of DNA extracted from formalin-fixed paraffin-embedded samples of the affected tissue. Read More

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http://dx.doi.org/10.1007/s11046-018-0296-zDOI Listing
February 2019
2 Reads

A Case Report of Mucormycosis with Palatal Ulcer: A Rare Clinical Dilemma.

J Coll Physicians Surg Pak 2018 Sep;28(9):721-723

Department of General Medicine, Suyash Multispeciality Hospital, Nashik, India.

Mucormycosis represents a group of life-threatening infections caused by fungi of the order mucorales of subphylum mucormycotina (formely known as the class zygomycetes). It is highly invasive and progressive disease resulting in higher rates of morbidity and mortality. Newer therapies have declined the rates of mortality. Read More

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http://dx.doi.org/10.29271/jcpsp.2018.09.721DOI Listing
September 2018

Iron restriction inside macrophages regulates pulmonary host defense against Rhizopus species.

Nat Commun 2018 08 20;9(1):3333. Epub 2018 Aug 20.

Department of Medicine, University of Crete, Foundation for Research and Technology, 71300, Heraklion, Crete, Greece.

Mucormycosis is a life-threatening respiratory fungal infection predominantly caused by Rhizopus species. Mucormycosis has incompletely understood pathogenesis, particularly how abnormalities in iron metabolism compromise immune responses. Here we show how, as opposed to other filamentous fungi, Rhizopus spp. Read More

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http://www.nature.com/articles/s41467-018-05820-2
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http://dx.doi.org/10.1038/s41467-018-05820-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102248PMC
August 2018
17 Reads
10.742 Impact Factor

Mucormycosis in hospitalized patients at a tertiary care center in Lebanon: a case series.

Infection 2018 Dec 18;46(6):811-821. Epub 2018 Aug 18.

Division of Infectious Diseases, American University of Beirut Medical Center, Riad El Solh, PO Box 11-0236, Beirut, 1107 2020, Lebanon.

Purpose: Mucormycosis (MCM) is a rare fungal infection affecting people with impaired immunity. Data related to MCM from Lebanon are scarce. The aim of this study is to shed light on the epidemiology, incidence, and outcome of patients with MCM hospitalized at a tertiary care center in Lebanon. Read More

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http://dx.doi.org/10.1007/s15010-018-1195-4DOI Listing
December 2018
16 Reads

Rare mould infections caused by Mucorales, Lomentospora prolificans and Fusarium, in San Diego, CA: the role of antifungal combination therapy.

Int J Antimicrob Agents 2018 Nov 9;52(5):706-712. Epub 2018 Aug 9.

Department of Medicine, University of California, San Diego, San Diego, CA, USA; Department of Medicine, Medical University of Graz, Graz, Austria. Electronic address:

Non-Aspergillus invasive mould infections (IMIs) are associated with devastating morbidity and mortality rates and are increasingly diagnosed in immunocompromised hosts. The aim of this study was to describe the epidemiology and outcomes of non-Aspergillus IMIs at a university hospital in San Diego, California, USA. A retrospective chart review of the medical records of all patients with cultures growing non-Aspergillus moulds at the microbiology laboratory in the Center for Academic Laboratory Medicine, Department of Pathology, University of California, San Diego (UCSD) Health between mid-2014 and mid-2017 (3-year period) was performed. Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2018.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231988PMC
November 2018
15 Reads

Identification of Mucorales in patients with proven invasive mucormycosis by polymerase chain reaction in tissue samples.

Mycoses 2018 Dec 28;61(12):909-915. Epub 2018 Aug 28.

Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Background: Accurate diagnosis of mucormycosis, a life-threatening fungal infection, remains a challenge for physicians.

Objectives: To identify the causative Mucorales in fresh clinical samples and formalin-fixed paraffin-embedded (FFPE) samples of patients with proven mucormycosis by molecular method.

Patients/methods: Fresh clinical samples of patients with proven mucormycosis according to the EORTC/MSG criteria admitted between 2015 and 2017 and histopathologically proven FFPE archives collected during 2004-2007 and 2015-2017 from Mazandaran University-affiliated hospitals of northern Iran were included. Read More

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http://dx.doi.org/10.1111/myc.12837DOI Listing
December 2018
16 Reads

Cutaneous mucormycosis.

Infection 2018 Dec 8;46(6):901-902. Epub 2018 Aug 8.

School of Medicine, Chang Gung University, Kweishan Township, Taoyuan, Taiwan.

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http://dx.doi.org/10.1007/s15010-018-1179-4DOI Listing
December 2018

Diagnosis of invasive fungal disease in hospitalized patients with chronic obstructive pulmonary disease.

Rev Iberoam Micol 2018 Jul - Sep;35(3):117-122. Epub 2018 Aug 2.

Servicio de Microbiología y Parasitología Clínica, Hospital Universitario Severo Ochoa de Madrid, Avda/ de Orellana s/n, 28911 Leganés, Spain.

Background: The role of culture-independent techniques (galactomannan, (1-3)-β-d-glucan) in the early diagnosis of invasive fungal diseases (IFD) is well assessed in hematological patients, but there are no clear conclusions in patients with chronic obstructive pulmonary disease (COPD).

Aims: To study the usefulness of nonculture-based techniques in the diagnosis of IFD in COPD-patients at risk for IFD.

Methods: A prospective observational study based on monitoring COPD patients at risk for IFD during 2007-2010 was carried out. Read More

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http://dx.doi.org/10.1016/j.riam.2017.07.004DOI Listing
August 2018
2 Reads

Cutaneous Mucormycosis by Saksenaea vasiformis: An Unusual Case Report and Review of Literature.

Mycopathologia 2019 Feb 30;184(1):159-167. Epub 2018 Jul 30.

First Department of General Surgery, General Hospital of Attica "KAT", 141 Oropou Str., 14232, Athens, Greece.

Background: Saksenaea vasiformis is one of the numerous fungi of the Order Mucorales. Rapid progression and invasion of neighboring tissues are the most characteristic features of S. vasiformis mucormycosis. Read More

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http://dx.doi.org/10.1007/s11046-018-0249-6DOI Listing
February 2019
10 Reads

Mucor mycelial thrombosis of the portal vein in an extremely low-birthweight infant.

Pediatr Int 2018 Aug 30;60(8):764-766. Epub 2018 Jul 30.

Department of Pathology, Kanagawa Children's Medical Center, Yokohama, Japan.

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http://dx.doi.org/10.1111/ped.13611DOI Listing
August 2018
2 Reads

Two for the price of one: emerging carbapenemases in a returning traveller to New York City.

BMJ Case Rep 2018 Jul 18;2018. Epub 2018 Jul 18.

Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA.

We report a case of a complex orthopaedic infection in a patient returning to New York City from Bangladesh where he was involved in a serious motor vehicle accident. He developed extensive osteomyelitis with a carbapenem-resistant The isolate was unique due to the coexistence of New Delhi metallo-β-lactamase-1 and Oxacillinase type-181 carbapenemases, which are relatively uncommon in North America and were presumably acquired in Bangladesh. Herein, we explore challenges associated with management of carbapenem-resistant Enterobacteriaceae infections, including limited available data on effective antimicrobial therapy. Read More

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http://dx.doi.org/10.1136/bcr-2018-225440DOI Listing
July 2018
6 Reads

Successful treatment of pulmonary mucormycosis in two pediatric hematopoietic stem cell transplant patients.

Pediatr Transplant 2018 11 16;22(7):e13270. Epub 2018 Jul 16.

Division of Oncology, Section of Cellular Therapy & Transplant, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Pulmonary mucormycosis diagnosed immediately after hematopoietic stem cell transplantation frequently portends a poor prognosis. However, here we describe two cases in children that were treated successfully to highlight the efficacy of a multidisciplinary approach. Despite diagnosis in the immediate post-transplant period and requirement for ongoing immunosuppression to prevent or treat GVHD, both are long-term survivors due to early surgical debridement with transfusion support and prompt initiation of targeted antifungal therapy. Read More

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http://doi.wiley.com/10.1111/petr.13270
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http://dx.doi.org/10.1111/petr.13270DOI Listing
November 2018
9 Reads

Orbitocerebral mucormycosis and intracranial haemorrhage: a role for caution with steroids in suspected giant cell arteritis.

BMJ Case Rep 2018 Jul 15;2018. Epub 2018 Jul 15.

Department of Neurosurgery, University Hospital of Wales, Cardiff, UK.

A 75-year-old man with type 2 diabetes mellitus presented with complete loss of vision in his right eye and severe headaches for the past 24 hours. He had been treated for suspected giant cell arteritis (GCA) with high-dose corticosteroids which were being tapered to stop after an inconclusive right temporal artery biopsy and an erythrocyte sedimentation rate (ESR) value of 8. His current acute presentation, however, raised further concern for partially treated GCA and precipitated treatment with pulsed methylprednisolone. Read More

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http://dx.doi.org/10.1136/bcr-2017-224086DOI Listing
July 2018
14 Reads

Intra-arterial spread of Mucormycetes mediates early ischemic necrosis of brain and suggests new venues for prophylactic therapy.

Neuropathology 2018 Oct 4;38(5):539-541. Epub 2018 Jul 4.

Department of Imaging/Neuroradiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Intracranial invasion by Mucormycosis carries high mortality mostly related to arterial occlusion and ischemic necrosis. We report clinical, imaging and autopsy findings in an adult immunodeficiency syndrome (AIDS) patient with fungal infection extending from a tooth. We report a striking discordance between a restriction of fungal growth to the initial branches of the circle of Willis and extensive ischemic infarcts of deep brain structures. Read More

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http://dx.doi.org/10.1111/neup.12501DOI Listing
October 2018
10 Reads

A rare case of gastric mucormycosis in an immunocompetent patient.

Rev Soc Bras Med Trop 2018 May-Jun;51(3):401-402

Radiologia, Hospital Guilherme Álvaro, Santos, SP, Brasil.

We report the case of a 23-year-old immunocompetent patient who presented at the emergency department of a Brazilian hospital with epigastric pain and fever. After an investigation that included a computed tomography scan and upper gastrointestinal endoscopy with biopsy, a diagnosis of mucormycosis was established. The patient exhibited favorable progress after surgery and antifungal therapy. Read More

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http://dx.doi.org/10.1590/0037-8682-0304-2017DOI Listing
July 2018
16 Reads

Infiltrating, Quasi-Cancerous Rectal Lesions: Unique Manifestation of Visceral Basidiobolus ranarum.

Indian J Pediatr 2018 Dec 14;85(12):1096-1100. Epub 2018 Jun 14.

Department of Pediatric Gastro-enterology, Abha Maternity and Children's Hospital, Abha, Saudi Arabia.

Objective: To report the finding of transmural rectal involvement, in four children with lesions which seemed to be neoplastic in appearance and progression.

Methods: The case records of four children presenting with rectal involvement by the fungus Basidiobolus ranarum, were retrospectively analyzed for clinical presentation, hematological and radiological investigations, the procurement of histopathological material for diagnosis and the findings thereof, the treatment of these patients and the follow-up.

Results: The four children presented with non-specific symptoms of fever, loss of weight and appetite, constipation and bleeding per rectum. Read More

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http://dx.doi.org/10.1007/s12098-018-2728-7DOI Listing
December 2018
8 Reads

Cutaneous mucormycosis caused by Rhizopus microsporus in an immunocompetent patient: A case report and review of literature.

Medicine (Baltimore) 2018 Jun;97(25):e11141

Department of Dermatology.

Rationale: Cutaneous mucormycosis is an uncommon disease and occurs rarely in immunocompetent patients.

Patient Concerns: We reported the case of a 37-year-old man presenting with a skin lesion on the left side of the chest wall with no history of trauma or primary diseases. He was firstly misdiagnosed as tuberculosis and the proper treatment was thus delayed. Read More

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http://dx.doi.org/10.1097/MD.0000000000011141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024029PMC
June 2018
6 Reads
5.720 Impact Factor

Economic impact of treating invasive mold disease with isavuconazole compared with liposomal amphotericin B in the UK.

Future Microbiol 2018 09 18;13:1283-1293. Epub 2018 Jun 18.

Basilea Pharmaceutica International Ltd, Basel, Switzerland.

Aim: Invasive mold diseases (IMDs) are associated with significant morbidity and mortality. Approved treatments include voriconazole (VORI), liposomal amphotericin B (L-AMB), posaconazole (POSA) and isavuconazole (ISAV). A UK-based economic model was developed to explore the cost of treating IMDs with ISAV versus L-AMB followed by POSA. Read More

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http://dx.doi.org/10.2217/fmb-2018-0119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190279PMC
September 2018
1 Read

Rhinocerebral mucormycosis, risk factors and the type of oral manifestations in patients referred to a University Hospital in Tabriz, Iran 2007-2017.

Mycoses 2018 Oct 2;61(10):764-769. Epub 2018 Jul 2.

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.

Inadequate data are available on the global epidemiology of mucormycosis, mainly derived from the evaluation of specific population groups. Rhinocerebral mucormycosis is an invading and fatal mycosis, particularly among diabetic patients. In the present study, patients hospitalised in Imam Reza Hospital in Tabriz, from 2007 to 2017, were evaluated. Read More

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http://dx.doi.org/10.1111/myc.12802DOI Listing
October 2018
6 Reads
1.805 Impact Factor

Gastrointestinal mucormycosis in apparently immunocompetent hosts-A review.

Mycoses 2018 Dec 20;61(12):898-908. Epub 2018 Jun 20.

Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research PGIMER, Chandigarh, India.

The diagnosis of gastrointestinal (GI) mucormycosis is always a challenge due to its non-specific clinical presentations and often diagnosed at autopsy. Recently increased number of GI mucormycosis has been reported in immunocompetent hosts and during 1948 through 2017, 200 cases of GI mucormycosis are available in literature. We could review 176 cases where case details were available. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/myc.12798
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http://dx.doi.org/10.1111/myc.12798DOI Listing
December 2018
7 Reads

Basidiobolomycosis: an unusual, mysterious, and emerging endemic fungal infection.

Paediatr Int Child Health 2018 05 24;38(2):81-84. Epub 2018 Apr 24.

b Division of Infectious Diseases , Mayo Clinic , Phoenix , AZ , USA.

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https://www.tandfonline.com/doi/full/10.1080/20469047.2018.1
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http://dx.doi.org/10.1080/20469047.2018.1458772DOI Listing
May 2018
7 Reads

Self-resolving superficial primary cutaneous mucormycosis in a 7-week-old infant.

Pediatr Dermatol 2018 Jul 30;35(4):e248-e250. Epub 2018 May 30.

Department of Pediatrics, Uniformed Services University, Bethesda, MD, USA.

A 7-week-old girl, born at 30 weeks' gestational age, presented to clinic for evaluation of a crop of vesicular lesions that were noted after removal of a bandage that had been in place for 4 days. A punch biopsy of the lesion revealed fungal elements that were later identified as Rhizopus spp. The lesion began to self-resolve, and no further treatment was needed, with full resolution of the lesion by 1 month after presentation. Read More

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http://dx.doi.org/10.1111/pde.13531DOI Listing

Neonatal Mucormycosis with Gastrointestinal and Cutaneous involvement.

Indian Pediatr 2018 May;55(5):427-428

Department of Pathology, Institute of Child Health and Hospital for Children, Egmore, Chennai, India.

Background: Mucormycosis of the gastrointestinal tract is a rare fungal infection of neonates.

Case Characteristics: 48-hours-old term neonate presented with intestinal obstruction and perforation. No significant risk factors were present. Read More

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May 2018
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Voriconazole associated mucormycosis in a patient with relapsed acute lymphoblastic leukemia and hematopoietic stem cell transplant failure: A case report.

J Mycol Med 2018 Sep 26;28(3):527-530. Epub 2018 May 26.

Department of Medical Mycology, School of Medicine/Invasive Fungi Research Center (IFRC), Mazandaran University of Medical Sciences, Sari, Iran. Electronic address:

The patients with hematologic malignancies and hematopoietic stem cell transplantation (HSCT) recipients are at high risk for invasive fungal diseases (IFDs) mainly due to the severe and prolonged neutropenia related to high-dose chemotherapy. Voriconazole prophylaxis is recommended for possible IFDs. Mucormycosis is a fulminant infection, which may occur after voriconazole prophylaxis for invasive aspergillosis in immunocompromised hosts. Read More

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http://dx.doi.org/10.1016/j.mycmed.2018.05.008DOI Listing
September 2018
1 Read

[Trichodysplasia spinulosa. Report of one case].

Rev Med Chil 2018 Jan;146(1):107-110

Unidad de Melanoma y Cáncer de Piel, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Trichodysplasia spinulosa is a rare disease that occurs in the setting of immunosuppression, associated with tolerogenic therapy used in allograft recipients or patients with hematologic malignancies. Clinically, it is characterized by a centrofacial cutaneous eruption of erythematous papules with a central keratinous spicule, often associated with variable degrees of alopecia. Histologic findings are characteristic, and electron microscopy reveals the presence of trichodysplasia spinulosa associated polyomavirus. Read More

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http://dx.doi.org/10.4067/s0034-98872018000100107DOI Listing
January 2018
3 Reads

Fatal Pulmonary and Cerebellar Zygomycosis due to Rhizomucor pusillus in a Ringed Seal (Pusa hispida).

Mycopathologia 2018 Dec 22;183(6):979-985. Epub 2018 May 22.

Laboratory of Veterinary Pathology, Obihiro University of Agriculture and Veterinary Medicine, W2-11, Inada, Obihiro, Hokkaido, 080-8555, Japan.

A 4-year-old captive ringed seal (Pusa hispida) was treated with subcutaneous antibacterial injections for pus exuding wounds in the skin and associated blubber following a bite attack. Three months after the incident, the animal presented nystagmus and died the following day. At necropsy, there was a 25 × 18 × 25 mm well-delineated, opaque nodular mass in the lung, besides the skin ulcers and localized areas of discoloration in the blubber correlating with the bite wound and injection sites. Read More

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http://dx.doi.org/10.1007/s11046-018-0268-3DOI Listing
December 2018
2 Reads

Non-sinonasal isolated facio-orbital mucormycosis - A case report.

J Mycol Med 2018 Sep;28(3):538-541

Department of Anesthesia, IMS and SUM hospital, Siksha "O" Anusandhan University, K8, Kalinganagar, 751003 Bhubaneswar, Odisha, India.

Mucormycosis is a rare clinical entity, often affect immunocompromised patients. It is an emergency situation and has poor prognosis. Prompt diagnosis with tissue biopsy, local control of the disease by aggressive surgical debridement and appropriate systemic antifungal treatment improve the prognosis and survival of the patients. Read More

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http://dx.doi.org/10.1016/j.mycmed.2018.05.003DOI Listing
September 2018
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[Retrospective study of 25 cases of pulmonary mucormycosis in acute leukaemia].

Rev Mal Respir 2018 Apr 10;35(4):452-464. Epub 2018 May 10.

Service d'hématologie clinique, hôpital François-Mitterrand, CHU de Dijon, 14, rue Gaffarel, 21079 Dijon cedex, France; Inserm unité 866, LabEx Team, faculté de médecine, 21079 Dijon, France.

Introduction: In acute leukaemia (AL), the occurrence of pulmonary mucormycosis (PM), the incidence of which is increasing, as a result of chemotherapy induced marrow aplasia, remains a life threatening complication.

Methods: Analysis of clinical, biological and thoracic CT characteristics of patients with PM developing during the treatment of AL between 2000 and 2015. Day 0 (D0) was defined as the day with first CT evidence of PM. Read More

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http://dx.doi.org/10.1016/j.rmr.2017.11.009DOI Listing
April 2018
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Spotlight on isavuconazole in the treatment of invasive aspergillosis and mucormycosis: design, development, and place in therapy.

Drug Des Devel Ther 2018 30;12:1033-1044. Epub 2018 Apr 30.

Department of Medicine, University of California San Diego, San Diego, CA, USA.

In recent decades, important advances have been made in the diagnosis and treatment of invasive aspergillosis (IA) and mucormycosis. One of these advances has been the introduction of isavuconazole, a second-generation broad spectrum triazole with a favorable pharmacokinetic and safety profile and few drug-drug interactions. Phase III trials in patients with IA and mucormycosis demonstrated that isavuconazole has similar efficacy to voriconazole for the treatment of IA (SECURE trial) and liposomal amphotericin B for the treatment of mucormycosis (VITAL trial with subsequent case-control analysis) and a favorable safety profile with significantly fewer ocular, hepatobiliary, and skin and soft tissue adverse events compared to voriconazole. Read More

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https://www.dovepress.com/spotlight-on-isavuconazole-in-the-
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http://dx.doi.org/10.2147/DDDT.S145545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933337PMC
September 2018
5 Reads

Characteristics of pulmonary mucormycosis and predictive risk factors for the outcome.

Infection 2018 Aug 10;46(4):503-512. Epub 2018 May 10.

Department of Respiratory Medicine, Peking Union Medical College Hospital, Beijing, China.

Purpose: Little is known about risk factors for the outcome of pulmonary mucormycosis. We summarized characteristics of this rare disease, and systemically explored risk factors for the outcome.

Methods: Ninety-two patients with pulmonary mucormycosis, including 12 patients at Peking Union Medical College Hospital and 80 patients published in 62 articles between 2006 and 2016, were retrospectively analyzed. Read More

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http://dx.doi.org/10.1007/s15010-018-1149-xDOI Listing
August 2018
2 Reads

A first-line antiretroviral therapy-resistant HIV patient with rhinoentomophthoromycosis.

Indian J Med Microbiol 2018 Jan-Mar;36(1):136-139

Department of Medical Microbiology, Sepsis Research Group, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.

The Conidiobolus coronatus-related rhinoentomophthoromycosis in immunocompetent and immunocompromised (HIV negative) individuals has been treated successfully with antifungal drugs. However, C. coronatus infections in first-line antiretroviral therapy (ART)-resistant (HIV infected) individuals particularly with rhinoentomophthoromycosis have not been reported previously. Read More

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http://www.ijmm.org/text.asp?2018/36/1/136/231656
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http://dx.doi.org/10.4103/ijmm.IJMM_16_330DOI Listing
September 2018
19 Reads

Total Gastric Necrosis Due to Mucormycosis: A Rare Case of Gastric Perforation.

Am J Case Rep 2018 May 4;19:527-533. Epub 2018 May 4.

Department of Pathology, Al-Amiri Hospital, Kuwait City, Kuwait.

BACKGROUND Spontaneous gastric perforation is usually a complication of peptic ulcer disease, or a postoperative complication resulting from gastric torsion. Mucormycosis (or zygomycosis) is an uncommon opportunistic fungal infection that is usually seen in immunocompromised patients and is associated with significant morbidity and mortality. This report is of a rare case of spontaneous gastric perforation due to mucormycosis infection. Read More

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http://dx.doi.org/10.12659/AJCR.908952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956728PMC
May 2018
5 Reads

Mucormycosis of maxilla following tooth extraction in immunocompetent patients: Reports and review.

J Clin Exp Dent 2018 Mar 1;10(3):e300-e305. Epub 2018 Mar 1.

Post-graduate student, Department of Prosthodontics, School of Dental Sciences, KIMSDU, Karad, Maharashtra, India.

Mucormycosis is a rare, fulminant, rapidly spreading fungal infection, which usually affects patient with underlying immune deficiency. If not managed promptly, the disease is characterized by progressive necrosis and is often fatal. A review of English literature shows that only fourteen cases of mucormycosis have been reported after tooth extraction. Read More

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http://dx.doi.org/10.4317/jced.53655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923886PMC
March 2018
1 Read