434 results match your criteria Zollinger-Ellison Syndrome Imaging


Management of Primary Lymph Nodal Gastrinoma With Liver Metastases Resulting in Zollinger-Ellison Syndrome.

Clin Nucl Med 2019 Jan;44(1):e36-e39

From the Departments of Nuclear Medicine.

Primary lymph node gastrinoma has been defined as gastrin-producing tumor present in lymph nodes and predominantly found in well-defined anatomical region known as gastrinoma triangle. They are usually localized preoperatively with imaging, and their surgical resection results in long-term relief. The authors report a case of unresectable primary lymph nodal gastrinoma with liver metastases in a 14-year-old adolescent boy with proven histopathology detected on Ga-DOTANOC whole-body PET/CT scan followed by preoperative multiple Lu-DOTATATE cycles for cytoreduction. Read More

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http://Insights.ovid.com/crossref?an=00003072-900000000-9736
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http://dx.doi.org/10.1097/RLU.0000000000002368DOI Listing
January 2019
23 Reads
3.931 Impact Factor

Multiple Endocrine Neoplasia Type 1: A Case Report With Review of Imaging Findings.

Ochsner J 2018 ;18(2):170-175

Department of Radiology, Ochsner Clinic Foundation, New Orleans, LA.

Background: Multiple endocrine neoplasia type 1 (MEN1) is a rare, autosomal dominant inherited syndrome caused by mutations in the MEN1 tumor suppressor gene. The diagnosis is defined clinically by the presence of 2 or more primary MEN1 tumors (parathyroid, anterior pituitary, and pancreatic islet). We describe the case of a patient who presented with classic history and imaging findings for MEN1. Read More

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http://dx.doi.org/10.31486/toj.17.0019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135292PMC
January 2018
6 Reads

Management of functional neuroendocrine tumors of the pancreas.

Authors:
Kjell Öberg

Gland Surg 2018 Feb;7(1):20-27

Department of Medical Sciences, Endocrine Oncology, Uppsala University Hospital, Uppsala, Sweden.

Pancreatic neuroendocrine tumors (pNETs) constitute a heterogenous group of malignancies with varying clinical presentation, tumor biology and prognosis. The incidence of pNETs has steadily increased during the last decades with an estimated incidence 2012 of 4.8/100,000. Read More

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http://dx.doi.org/10.21037/gs.2017.10.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876681PMC
February 2018
21 Reads

Prospective Evaluation of Results of Reoperation in Zollinger-Ellison Syndrome.

Ann Surg 2018 04;267(4):782-788

Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.

Objective: To determine the role of reoperation in patients with persistent or recurrent Zollinger-Ellison Syndrome (ZES).

Background: Approximately, 0% to 60% of ZES patients are disease-free (DF) after an initial operation, but the tumor may recur.

Methods: A prospective database was queried. Read More

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http://dx.doi.org/10.1097/SLA.0000000000002122DOI Listing
April 2018
16 Reads

Diagnosis of Zollinger-Ellison syndrome in the era of PPIs, faulty gastrin assays, sensitive imaging and limited access to acid secretory testing.

Int J Endocr Oncol 2017 11;4(4):167-185. Epub 2017 Oct 11.

Digestive Diseases Branch, NIDDK, NIH, Bethesda, Maryland, 20817, USA.

In recent years the diagnosis of Zollinger-Ellison syndrome (ZES) has become increasingly controversial with several new approaches and criteria proposed, differing from the classical biochemical criterion of inappropriate hypergastrinemia (i.e., hypergastrinemia in the presence of hyperchlorhydria) (Table 1). Read More

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http://dx.doi.org/10.2217/ije-2017-0018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757869PMC
October 2017
12 Reads

Going from A to Z.

N Engl J Med 2018 01;378(1):73-79

From the Department of Medicine, Johns Hopkins Hospital and Johns Hopkins University School of Medicine, Baltimore (D.A., D.F., R.M.); and the Department of Medicine, University of California, San Francisco, and the Medical Service, San Francisco Veterans Affairs Medical Center - both in San Francisco (G.D., K.R.F.).

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January 2018
20 Reads

Hormone secreting gastro-entero-pancreatic neuroendocrine neoplasias (GEP-NEN): When to consider, how to diagnose?

Rev Endocr Metab Disord 2017 12;18(4):393-410

Schwerpunkt Endokrinologie und Stoffwechselerkrankungen, I. Medizinischen Klinik und Poliklinik; ENETS center of excellence, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Langenbeckstrasse 1, 55101, Mainz, Germany.

Neuroendocrine neoplasms of the digestive system (GEP-NEN) represent a heterogeneous group of malignancies with various clinical presentation and prognosis. GEP-NENs can potentially affect all organs of the gastrointestinal tract; characteristically they share the biological property to produce and secrete peptides and neuroamines. About 30% of GEP-NENs are hormonally active and can cause specific clinical syndromes. Read More

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http://dx.doi.org/10.1007/s11154-017-9438-8DOI Listing
December 2017
17 Reads

Catching the Zebra: Clinical Pearls and Pitfalls for the Successful Diagnosis of Zollinger-Ellison Syndrome.

Dig Dis Sci 2017 09 3;62(9):2258-2265. Epub 2017 Aug 3.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Zollinger-Ellison syndrome (ZES) results from an ectopic gastrin-secreting tumor leading to peptic ulcer disease, reflux, and chronic diarrhea. While early recognition portends an excellent prognosis with >80% survival at 15 years, symptoms are often nonspecific making the diagnosis difficult to establish. Diagnosis involves a series of tests, including fasting gastrin, gastric pH, chromogranin A, and secretin stimulation. Read More

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http://dx.doi.org/10.1007/s10620-017-4695-7DOI Listing
September 2017
27 Reads

Gastrointestinal: Zollinger-Ellison Syndrome: A rare cause of chronic diarrhea and abdominal pain.

J Gastroenterol Hepatol 2017 Jul;32(7):1281

Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN, USA.

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http://dx.doi.org/10.1111/jgh.13630DOI Listing
July 2017
6 Reads

Occupational contact allergy to omeprazole and ranitidine.

Med Pr 2017 May 20;68(3):433-435. Epub 2017 Mar 20.

University of Barcelona, Barcelona, Spain (Unit of Occupational Medicine, School of Medicine).

Omeprazole is a proton pump inhibition and ranitidine is an H2 histamine receptor antagonist widely used in the treatment of gastroesophageal reflex disease, peptic ulcer disease, Zollinger-Ellison syndrome and as a protector of the gastric mucosae. We report a case of occupational contact allergy to omeprazole and ranitidine. A 48-year-old man, with no pre-existing history of atopy or lifestyle factors. Read More

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http://dx.doi.org/10.13075/mp.5893.00612DOI Listing
May 2017
50 Reads

A case of type 1 multiple endocrine neoplasia with esophageal stricture successfully treated with endoscopic balloon dilation and local steroid injection combined with surgical resection of gastrinomas.

BMC Gastroenterol 2017 Mar 7;17(1):37. Epub 2017 Mar 7.

Division of Endoscopy, Shizuoka Cancer Center, 1007, Shimonagakubo, Nagaizumi, Suntogun, Shizuoka, 411-8777, Japan.

Background: In type 1 multiple endocrine neoplasia (MEN1), esophageal diseases association with excessive gastrin secretion in Zollinger-Ellison syndrome (ZES) sometimes develop. Here, we reported a case of MEN1/ZES, who developed dysphagia due to reflux esophagitis with severe esophageal stricture. Treatment for his esophageal stricture and ZES was discussed. Read More

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http://dx.doi.org/10.1186/s12876-017-0597-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341352PMC
March 2017
27 Reads

Assessing for Multiple Endocrine Neoplasia Type 1 in Patients Evaluated for Zollinger-Ellison Syndrome-Clues to a Safer Diagnostic Process.

Am J Med 2017 May 21;130(5):603-605. Epub 2016 Dec 21.

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Mayo Clinic, Rochester, Minn. Electronic address:

Background: Zollinger-Ellison syndrome is a rare cause of tumoral hypergastrinemia; 1 of 5 patients with this syndrome also has multiple endocrine neoplasia type 1. The diagnosis of this disease is complicated by the widespread use of proton pump inhibitors that can elevate serum gastrin levels, the cornerstone for biochemical diagnosis. Abrupt discontinuation of proton pump inhibitors could lead to adverse outcomes. Read More

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http://dx.doi.org/10.1016/j.amjmed.2016.11.035DOI Listing
May 2017
12 Reads

Treatment of symptomatic neuroendocrine tumor syndromes: recent advances and controversies.

Expert Opin Pharmacother 2016 Nov 23;17(16):2191-2205. Epub 2016 Sep 23.

b Digestive Diseases Branch , NIDDK, NIH , Bethesda , MD , USA.

Introduction: Neuroendocrine tumors(NETs), once thought rare, are increasing in frequency in most countries and receiving increasing-attention. NETs present two-treatment problems. A proportion is aggressive and a proportion has a functional, hormone-excess-state(F-NET), each of which must be treated. Read More

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http://dx.doi.org/10.1080/14656566.2016.1236916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545682PMC
November 2016
11 Reads

[Management of gastrinoma].

Presse Med 2016 Nov 1;45(11):986-991. Epub 2016 Jun 1.

AP-HP, hôpital Cochin, service de chirurgie digestive hépato-biliaire et endocrienne, Paris, France; Université Paris Descartes, 12, rue de l'École-de-Médecine, 75006 Paris, France. Electronic address:

Gastrinoma is a very rare tumor leading to gastrin hypersecretion and characterised by Zollinger-Ellisson syndrome (ZES) i.e. severe gastric and duodenal ulceration and profuse diarrhea. Read More

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http://dx.doi.org/10.1016/j.lpm.2016.04.012DOI Listing
November 2016
4 Reads

Imaging in multiple endocrine neoplasia type 1: recent studies show enhanced sensitivities but increased controversies.

Int J Endocr Oncol 2016;3(1):53-66. Epub 2016 Jan 18.

Digestive Diseases Branch, NIDDK, NIH, Bethesda, MD 20817, USA.

In multiple endocrine neoplasia type 1 (MEN1) patients, a number of recent studies compare the ability of different, new imaging modalities to existing modalities to localize the important neuroendocrine tumors (NETs) that contribute to their decreased life expectancy (pancreatic NETs [pNETs] and thymic carcinoids). These included the use of Ga-DOTATOC-PET/CT, endoscopic ultrasound and MRI. The current paper analyzes these results in light of current guidelines and controversies involved in the treatment/management of MEN1 patients. Read More

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http://dx.doi.org/10.2217/ije.15.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728712PMC
January 2016
20 Reads

Intraoperative near-infrared fluorescence visualization of the duodenal gastrinoma in a patient with Zollinger-Ellison syndrome.

Surgery 2016 May 21;159(5):1474-6. Epub 2015 Jul 21.

Department of Surgery, University of Medicine and Pharmacy "Iuliu Hatieganu," Cluj-Napoca, Romania.

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http://dx.doi.org/10.1016/j.surg.2015.06.029DOI Listing
May 2016
14 Reads

Intraoperative Use of a Portable Large Field of View Gamma Camera and Handheld Gamma Detection Probe for Radioguided Localization and Prediction of Complete Surgical Resection of Gastrinoma: Proof of Concept.

J Am Coll Surg 2015 Aug 1;221(2):300-8. Epub 2015 Apr 1.

Department of Surgery, College of Public Health, The Ohio State University, Wexner Medical Center, Columbus, OH.

Background: Surgical management of Zollinger-Ellison syndrome (ZES) relies on localization and resection of all tumor foci. We describe the benefit of combined intraoperative use of a portable large field of view gamma camera (LFOVGC) and a handheld gamma detection probe (HGDP) for indium-111 ((111)In)-pentetreotide radioguided localization and confirmation of gastrinoma resection in ZES.

Study Design: Five patients (6 cases) with (111)In-pentetreotide-avid ZES were evaluated. Read More

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http://dx.doi.org/10.1016/j.jamcollsurg.2015.03.047DOI Listing
August 2015
9 Reads

Gastric neuroendocrine neoplasms and proton pump inhibitors: fact or coincidence?

Scand J Gastroenterol 2015 10;50(11):1397-403. Epub 2015 Jun 10.

Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Gastroenterology and Endoscopic Unit , Milan , Italy.

Objective: Reporting on three cases of gastric neuroendocrine tumors (g-NETs) in patients taking long-term proton pump inhibitors (PPIs). These tumors are not classifiable considering current criteria. g-NETs are currently grouped as: types 1 and 2, related to hypergastrinemia due to chronic atrophic gastritis and Zollinger-Ellison syndrome respectively, and type 3, normogastrinemic and more aggressive. Read More

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http://dx.doi.org/10.3109/00365521.2015.1054426DOI Listing
May 2016
19 Reads

Determinants of surgical resection for pancreatic neuroendocrine tumors.

Authors:
Ryuichiro Doi

J Hepatobiliary Pancreat Sci 2015 Aug 13;22(8):610-7. Epub 2015 Mar 13.

Department of Surgery, Otsu Red Cross Hospital, 1-1-35 Nagara, Otsu, Shiga, 520-8511, Japan.

Pancreatic neuroendocrine tumors (pNETs) include functioning and non-functional tumors. Functioning tumors consist of tumors that produce a variety of hormones and their clinical effects. Therefore, determinants of resection of pNETs should be discussed for each group of tumors. Read More

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http://dx.doi.org/10.1002/jhbp.224DOI Listing
August 2015
5 Reads

[Surgery for gastrinoma: Short and long-term results].

Cir Esp 2015 Jun-Jul;93(6):390-5. Epub 2015 Mar 3.

Departamento de Cirugía, Universidad de Barcelona, Hospital Clínic de Barcelona, Barcelona, España.

Introduction: Zollinger-Ellison syndrome (Z-E) is characterized by gastrin-secreting tumors, responsible for causing refractory and recurrent peptic ulcers in the gastrointestinal tract. The optimal approach and the extension of tumor resection remains the subject of debate.

Methods: During the period February 2005 and February 2014, 6 patients with Z-E underwent surgery, 4 men and 2 women with a median age 46. Read More

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http://dx.doi.org/10.1016/j.ciresp.2014.10.016DOI Listing
June 2017
5 Reads

Primary lymph node gastrinoma. A diagnosis of exclusion. A case for duodenotomy in the setting of a negative imaging for primary tumor: A case report and review of the literature.

Int J Surg Case Rep 2014 17;5(11):849-52. Epub 2014 Oct 17.

Department of Surgery, Mount Sinai-St. Luke's-Roosevelt Hospital Center, New York, NY, United States.

Introduction: Zollinger-Ellison syndrome (ZES) is caused by uninhibited secretion of gastrin from a gastrinoma. Gastrinomas most commonly arise within the wall of the duodenum followed by the pancreas. Primary lymph node gastrinomas have also been reported in the literature. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612140020
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http://dx.doi.org/10.1016/j.ijscr.2014.08.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245667PMC
June 2016
13 Reads

Case of primary hepatic gastrinoma: Diagnostic usefulness of the selective arterial calcium injection test.

Hepatol Res 2015 Jul 18;45(7):823-6. Epub 2014 Sep 18.

Department of Pathology, Kobe City Medical Center General Hospital, Kobe, Japan.

Gastrinomas mainly occur in the duodenum and pancreas. Primary hepatic gastrinoma is rare and difficult to diagnose because the liver is a frequent site of metastatic gastrinomas. Clinical factors were assessed in a 28-year-old man with diarrhea and heartburn who was hospitalized for recurrent duodenal ulcers. Read More

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http://dx.doi.org/10.1111/hepr.12404DOI Listing
July 2015
32 Reads

Zollinger-Ellison syndrome: classical considerations and current controversies.

Oncologist 2014 Jan 6;19(1):44-50. Epub 2013 Dec 6.

Department of Surgery, Columbia University Medical Center, New York, New York, USA; Department of Surgery, Hadassah-Hebrew University Medical Center, Mount Scopus, Jerusalem, Israel.

Zollinger-Ellison syndrome (ZES) is an endocrinopathy characterized by gastrin-secreting tumors, responsible for causing the formation of multiple, refractory, and recurrent peptic ulcers in the distal duodenum and proximal jejunum. Two main variants have been described, sporadic and those found in association with parathyroid and pituitary tumors, a genetic disorder known as multiple endocrine neoplasia-1 (MEN-1). Biochemical serum evaluation for elevated gastrin, followed by radiological or nuclear localization of the primary lesion, is mandated for establishing diagnosis. Read More

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http://dx.doi.org/10.1634/theoncologist.2013-0369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903066PMC
January 2014
4 Reads

Current management of the Zollinger-Ellison syndrome.

Adv Surg 2013 ;47:59-79

Stanford University School of Medicine, Department of Surgery, 300 Pasteur Drive, H3591, Stanford, CA 94305-5655, USA.

In summary, ZES is a syndrome caused by gastrinoma, usually located within the gastrinoma triangle and associated with symptoms of peptic ulcer disease, GERD, and diarrhea. The diagnosis of ZES is made by measuring fasting levels of serum gastrin, BAO, and the secretin stimulation test. Because of the high association of ZES and MEN1, HPT must be excluded by obtaining a serum calcium and parathyroid hormone level. Read More

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January 2014
7 Reads

Beyond the GIST: mesenchymal tumors of the stomach.

Radiographics 2013 Oct;33(6):1673-90

Departments of Diagnostic Radiology and Pathology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1473, Houston, TX 77030; Department of Radiology, Mayo Clinic, Tucson, Ariz.

Intramural gastric masses arise in the wall of the stomach (generally within the submucosa or muscularis propria), often with intact overlying mucosa. These tumors are typically mesenchymal in origin and have overlapping radiologic appearances. A combination of features such as location, attenuation, enhancement, and growth pattern may suggest one diagnosis over another. Read More

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http://pubs.rsna.org/doi/10.1148/rg.336135507
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http://dx.doi.org/10.1148/rg.336135507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794320PMC
October 2013
8 Reads

A case of Zollinger-Ellison syndrome in multiple endocrine neoplasia type 1 with urolithiasis as the initial presentation.

Korean J Gastroenterol 2013 Jun;61(6):333-7

Division of Gastroenterology, Department of Internal Medicine, Presbyterian Medical Center, Jeonju, Korea.

Zollinger-Ellison syndrome (ZES) is characterized by gastrinoma and resultant hypergastrinemia, which leads to recurrent peptic ulcers. Because gastrinoma is the most common pancreatic endocrine tumor seen in multiple endocrine neoplasia type I (MEN 1), the possibility of gastrinoma should be investigated carefully when patients exhibit symptoms associated with hormonal changes. Ureteral stones associated with hyperparathyroidism in the early course of MEN 1 are known to be its most common clinical manifestation; appropriate evaluation and close follow-up of patients with hypercalcemic urolithiasis can lead to an early diagnosis of gastrinoma. Read More

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June 2013
17 Reads

Hypochlorhydria and achlorhydria are associated with false-positive secretin stimulation testing for Zollinger-Ellison syndrome.

Pancreas 2013 Aug;42(6):932-6

Division of Gastroenterology and Nutrition, Memorial-Sloan Kettering Cancer Center, New York, NY, USA.

Objectives: Secretin stimulation testing (SST) is used to evaluate patients with hypergastrinemia in the diagnosis of Zollinger-Ellison syndrome. Case series have documented false-positive SST in patients with achlorhydria. This study reviews our experience with SST in hypochlorhydric and achlorhydric patients. Read More

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http://dx.doi.org/10.1097/MPA.0b013e3182847b2eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712291PMC
August 2013
11 Reads

Gastric and duodenal neuroendocrine tumours.

Best Pract Res Clin Gastroenterol 2012 Dec;26(6):719-35

Department of Gastroenterology and Clinical Medicine, St James's Hospital and Trinity College, Dublin, Ireland.

Gastric neuroendocrine neoplasms (NENs) are increasing in frequency and have a varied spectrum with regard to histology, clinicopathologic background, stage, and prognosis. They are usually discovered incidentally, are for the most part benign and are associated with hypergastrinaemia (secondary either to chronic atrophic gastritis or rarely Zollinger-Ellison syndrome; types 1 and 2, respectively) or more rarely sporadic type 3. Applications of recent staging and grading systems - namely using Ki-67 proliferative indices - (from ENETS and WHO 2010) can be particularly helpful in further categorising these tumours. Read More

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http://dx.doi.org/10.1016/j.bpg.2013.01.002DOI Listing
December 2012
3 Reads

Multiple endocrine neoplasia type 1 with upper gastrointestinal hemorrhage and perforation: a case report and review.

World J Gastroenterol 2013 Feb;19(8):1322-6

Department of Gastroenterology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.

Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary syndrome known to predispose subjects to endocrine neoplasms in a variety of tissues such as the parathyroid glands, pituitary gland, pancreas and gastrointestinal tract. We herein report a patient with a past history of pituitary adenoma, presenting with symptoms of chronic diarrhea for nearly one year and a sudden upper gastrointestinal hemorrhage as well as perforation without signs. Nodules in the duodenum and in the uncinate process and tail of pancreas and enlargement of the parathyroid glands were detected on preoperative imaging. Read More

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http://dx.doi.org/10.3748/wjg.v19.i8.1322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587492PMC
February 2013
5 Reads

Primary hepatic gastrinoma as an unusual manifestation of zollinger-ellison syndrome.

Case Rep Gastroenterol 2012 Sep 18;6(3):590-5. Epub 2012 Sep 18.

Departments of Gastroenterology and Hepatology.

We report a rare case of primary hepatic gastrinoma. A 77-year-old woman exhibited continuous watery diarrhea for 8 months and weight loss. Bacterial cultures of the stools were negative and colonoscopy revealed no abnormalities. Read More

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http://dx.doi.org/10.1159/000343157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529581PMC
September 2012
12 Reads

Surgical treatment of gastrinomas: a single-centre experience.

HPB (Oxford) 2012 Dec 2;14(12):833-8. Epub 2012 Sep 2.

Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands.

Background: Gastrinomas are rare neuroendocrine tumours, and responsible for Zollinger-Ellison syndrome (ZES). Surgery is the only treatment that can cure gastrinomas. The success of surgical treatment of gastrinomas in a single centre was evaluated. Read More

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http://dx.doi.org/10.1111/j.1477-2574.2012.00551.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521912PMC
December 2012
4 Reads

[PPI-sensitive diarrhea - unusual case of an adolescent with sporadic gastrinoma].

Dtsch Med Wochenschr 2012 Sep 6;137(37):1797-800. Epub 2012 Sep 6.

Medizinische Klinik, Israelitisches Krankenhaus, Hamburg.

History And Clinical Findings: A 14-year-old boy was admitted to hospital because of chronic episodic diarrhea lasting for 4 years. Previous investigations in the past had not revealed the cause of the symptoms.

Investigations: The 13C-triglyceride breathing test showed a diminished intestinal lipolysis. Read More

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http://dx.doi.org/10.1055/s-0032-1305236DOI Listing
September 2012
4 Reads

Value of surgery in patients with negative imaging and sporadic Zollinger-Ellison syndrome.

Ann Surg 2012 Sep;256(3):509-17

Stanford University Medical Center, Stanford, CA 94305, USA.

Objectives: To address the value of surgery in patients with sporadic Zollinger-Ellison syndrome (ZES) with negative imaging studies.

Background: Medical control of acid hypersecretion in patients with sporadic ZES is highly effective. This has led to these patients frequently not being sent to surgery, especially if preoperative imaging studies are negative, due, in large part, to existence of almost no data on the success of surgery in this group. Read More

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http://dx.doi.org/10.1097/SLA.0b013e318265f08dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477644PMC
September 2012
7 Reads

Hemobilia due to biliary intraepithelial neoplasia associated with Zollinger-Ellison syndrome.

Clin J Gastroenterol 2012 Jun 21;5(3):189-94. Epub 2012 Apr 21.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan.

A 58-year-old man was transferred to us from his local hospital because of failure to control his gastrointestinal bleeding by endoscopic hemostasis. Abdominal imaging suggested a hypervascular tumor of the pancreatic head (36 mm diameter), and laboratory testing showed an elevated serum gastrin level (17,800 pg/mL). Gastroduodenal endoscopy revealed multiple duodenal ulcers and active bleeding from the ampulla of Vater. Read More

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http://dx.doi.org/10.1007/s12328-012-0296-3DOI Listing
June 2012
12 Reads

A thymic carcinoid tumour causing Zollinger-Ellison and Cushing's syndromes due to ectopic ACTH and gastrin secretion.

Hormones (Athens) 2013 Apr-Jun;12(2):305-8

Diabetes and Endocrine Unit, National Hospital of Sri Lanka, Sri Lanka.

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March 2014
10 Reads

Simultaneous large cell neuroendocrine carcinoma and adenocarcinoma of the stomach.

World J Gastroenterol 2011 Nov;17(43):4831-4

Department of Pathology, Shizuoka City Shimizu Hospital, 424-8636 Shizuoka, Japan.

A large cell neuroendocrine carcinoma (LCNEC) of the stomach is very rare. A 76-year-old Japanese man was admitted to our hospital because of epigastralgia and nausea. Endoscopy revealed 2 large tumors in the stomach. Read More

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http://dx.doi.org/10.3748/wjg.v17.i43.4831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229634PMC
November 2011
4 Reads

Long-term results of surgery for pancreatic neuroendocrine neoplasms in patients with MEN1.

Langenbecks Arch Surg 2011 Dec 30;396(8):1187-96. Epub 2011 Jul 30.

Department of Surgery, Philipps University Marburg, Baldingerstraße, 35043, Marburg, Germany.

Purpose: This study was made to evaluate long-term results of an aggressive surgical approach for pancreaticoduodenal neuroendocrine neoplasms (pNENs) in patients with multiple endocrine neoplasia type 1 (MEN1).

Methods: MEN1 patients with either biochemical evidence of functioning or non-functioning pNENs larger than 1 cm in size on imaging underwent duodenopancreatic surgery. Since 1997, patients were followed annually by biochemical testing and imaging studies. Read More

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http://link.springer.com/content/pdf/10.1007/s00423-011-0828
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http://link.springer.com/10.1007/s00423-011-0828-1
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http://dx.doi.org/10.1007/s00423-011-0828-1DOI Listing
December 2011
14 Reads

Bulky gastrinoma of the common bile duct: unusual localization of extrapancreatic gastrinoma--case report.

Turk J Gastroenterol 2011 ;22(2):219-23

Department of Endocrinology and Metabolism, Marmara University Hospital, İstanbul, Turkey.

Zollinger-Ellison syndrome is characterized by elevated levels of serum gastrin associated with increased gastric acid secretion, gastrointestinal ulcerations and diarrhea. Most gastrinomas (75%) occur sporadically and are located within the gastrinoma triangle. Extraduodenal, extrapancreatic and extranodal gastrinomas have been shown in 5. Read More

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December 2011
40 Reads

Primary hepatic gastrinoma: Report of a case and review of literature.

World J Gastrointest Pathophysiol 2011 Apr;2(2):26-30

Konstantinos Tsalis, Georgios Vrakas, Abraham Dimoulas, Charalampos Lazarides, Fourth Surgical Department, Aristotle University, Thessaloniki 57010, Greece.

Primary hepatic gastrinoma is a very rare ectopic gastrinoma with less than 20 cases reported worldwide. We report the case of a patient with hypergastrinemia who was subjected to exhaustive preoperative and intraoperative imaging and also careful surgical exploration of the duodenum and pancreas which failed initially to identify the primary tumour. Eventually the patient was subjected to left liver lobectomy, as a small palpable lesion was noted intraoperatively. Read More

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http://dx.doi.org/10.4291/wjgp.v2.i2.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097966PMC
April 2011
5 Reads

Pancreatic endocrine tumors or apudomas.

Rev Esp Enferm Dig 2011 Apr;103(4):184-90

Unit of Digestive Echoendoscopy, Centro Médico Teknon, Barcelona, Spain.

Introduction And Objective: pancreatic endocrine tumors (PET) are difficult to diagnose. Their accurate localization using imaging techniques is intended to provide a definite cure. The goal of this retrospective study was to review a PET series from a private institution. Read More

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April 2011
6 Reads

Biochemically curative surgery for gastrinoma in multiple endocrine neoplasia type 1 patients.

World J Gastroenterol 2011 Mar;17(10):1343-53

Department of Surgery, Kansa Electric Power Company Hospital, Osaka, Japan.

Aim: To search for the optimal surgery for gastrinoma and duodenopancreatic neuroendocrine tumors in patients with multiple endocrine neoplasia type 1.

Methods: Sixteen patients with genetically confirmed multiple endocrine neoplasia type 1 (MEN 1) and Zollinger-Ellison syndrome (ZES) underwent resection of both gastrinomas and duodenopancreatic neuroendocrine tumors (NETs) between 1991 and 2009. For localization of gastrinoma, selective arterial secretagogue injection test (SASI test) with secretin or calcium solution was performed as well as somatostatin receptor scintigraphy (SRS) and other imaging methods such as computed tomography (CT) or magnetic resonance imaging (MRI). Read More

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http://dx.doi.org/10.3748/wjg.v17.i10.1343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068271PMC
March 2011
5 Reads

An enucleated duodenal gastrinoma with multiple type 1 endocrine neoplasia located by selective arterial calcium injection.

Nihon Shokakibyo Gakkai Zasshi 2011 Jan;108(1):80-7

Department of Gastroenterology, Yamagata City Hospital Saiseikan.

We report a duodenal gastrinoma in a 50-year-old man who was admitted to our hospital with tarry stools. Esophagogastroduodenoscopy revealed multiple ulcers in the duodenal bulb and a submucosal tumor in the descending duodenum. His serum gastrin level was 1400pg/ml. Read More

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January 2011
8 Reads

Zollinger-Ellison syndrome: presentation, response to therapy, and outcome.

Dig Liver Dis 2011 Jun 30;43(6):439-43. Epub 2010 Dec 30.

University of Alabama at Birmingham, Division of Gastroenterology and Hepatology, Birmingham, AL, United States.

Background: Recent series describing the clinical presentation, response to therapy, and long-term outcome of Zollinger-Ellison syndrome are limited.

Aims: To assess the clinical characteristics and long-term outcome of patients with Zollinger-Ellison syndrome.

Methods: Over a 20-year period, patients with Zollinger-Ellison syndrome were enrolled in a prospective trial evaluating the efficacy of lansoprazole. Read More

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http://dx.doi.org/10.1016/j.dld.2010.11.007DOI Listing
June 2011
13 Reads

Pancreatic endocrine tumors.

Authors:
Kjell Oberg

Semin Oncol 2010 Dec;37(6):594-618

Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden.

Pancreatic endocrine tumors have been steadily growing in incidence and prevalence during the last two decades, showing an incidence of 4-5/1,000,000 population. They represent a heterogeneous group with very varying tumor biology and prognosis. About half of the patients present clinical symptoms and syndromes related to substances released from the tumors (Zollinger-Ellison syndrome, insulinoma, glucagonoma, etc) and the other half are so-called nonfunctioning tumors mainly presenting with symptoms such as obstruction, jaundice, bleeding, and abdominal mass. Read More

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http://dx.doi.org/10.1053/j.seminoncol.2010.10.014DOI Listing
December 2010
3 Reads

Diagnosis and treatment of Zollinger Ellison syndrome in a morbidly obese patient after Roux-en-Y gastric bypass.

Surg Obes Relat Dis 2010 Nov-Dec;6(6):714-7. Epub 2010 Aug 31.

Department of Minimally Invasive Surgery, Cleveland Clinic Florida, Weston, Florida 33331, USA.

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http://dx.doi.org/10.1016/j.soard.2010.06.009DOI Listing
April 2011
5 Reads

Reoperative surgery for the Zollinger-Ellison syndrome.

Adv Surg 2010 ;44:327-46

Division of Surgical Oncology, Department of Surgery, University of Florida, 1600 SW Archer Road, Room 6165, P.O. Box 100109, Gainesville, FL 32610, USA.

It is clear that a properly performed initial operation is the key to success in the management of a patient with ZES. However, reoperation is frequently a consideration in the management of patients with ZES because high rates of persistent and recurrent disease are manifest even with modern imaging and surgical approaches. In carefully selected patients, reoperation can result in durable biochemical cure and improved survival and should be considered. Read More

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October 2010
6 Reads

[Peripancreatic sporadic gastrinoma].

Tunis Med 2010 Oct;88(10):761-4

Service de chirurgie A, hôpital de La Rabta, 1007 Jabbari, Tunis, Tunisie.

Background: The peri-pancreatic sporadic gastrinoma represents a paradigm of digestive endocrinology. It was originally an abnormal secretion of gastrin fits the syndrome Zollinger-Ellison.

Aim: The objective of our work is to clarify the diagnostic strategy and therapeutic conduct of gastrinoma. Read More

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October 2010
9 Reads

"Paramedics are bringing in a hypotensive gastrointestinal bleeder": an unexpected diagnosis.

J Emerg Med 2012 Oct 24;43(4):e227-9. Epub 2010 Apr 24.

Department of Emergency Medicine, University of Arizona, Tucson, Arizona 85724-5057, USA.

Background: Acute esophageal rupture is a rare emergency that must be diagnosed quickly and treated aggressively to avoid significant morbidity and mortality. The typical presentation of this disease includes chest pain, and the diagnosis is challenging when cardinal features such as this are absent.

Objectives: This case report discusses an atypical presentation of esophageal rupture in a patient with a predisposing condition and highlights the diagnostic and cognitive difficulties involved in making the appropriate diagnosis. Read More

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http://dx.doi.org/10.1016/j.jemermed.2010.02.031DOI Listing
October 2012
2 Reads

Surgical management of Zollinger-Ellison syndrome; state of the art.

Surg Clin North Am 2009 Oct;89(5):1091-103

Division of General Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305-5641, USA.

Much has been learned about the diagnosis and treatment of Zollinger-Ellison Syndrome (ZES), and certain questions require further investigation. Delay in diagnosis of ZES is still a significant problem, and clinical suspicion should be elevated. The single best imaging modality for localization and staging of ZES is somatostatin receptor scintigraphy. Read More

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http://dx.doi.org/10.1016/j.suc.2009.06.018DOI Listing
October 2009
1 Read