3,618 results match your criteria Zollinger-Ellison Syndrome


Identification of Helicobacter pylori-related gastric cancer risk using serological gastritis markers and endoscopic findings: a large-scale retrospective cohort study.

BMC Gastroenterol 2022 Jun 20;22(1):299. Epub 2022 Jun 20.

Department of Endoscopy, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, Hiroshima, 734-8553, Japan.

Background: Gastric cancer remains a severe public health problem worldwide, particularly in Japan. Recent studies have demonstrated that serum markers are beneficial for risk stratification in gastric cancer development. We aimed to evaluate the usefulness of serum markers either alone or in combination (serum markers plus endoscopy) for effective risk stratification of gastric cancer development. Read More

View Article and Full-Text PDF

Double Peptic Ulcer Perforation due to Cumulative Effects of Post-surgery Stress and NSAIDs: A Rare Event in Surgical Practice.

J Coll Physicians Surg Pak 2022 Apr;32(4):S21-S23

Department of General Surgery, Nishtar Hospital, Multan, Pakistan.

Peptic ulcer disease affects a large number of people around the world. Complications occur in 10-20% of patients and perforation develops in 2-14% of the cases. It can either be in the pyloric part of the stomach or in the first part of duodenum. Read More

View Article and Full-Text PDF

Pancreaticoduodenectomy Is the Best Surgical Procedure for Zollinger-Ellison Syndrome Associated with Multiple Endocrine Neoplasia Type 1.

Cancers (Basel) 2022 Apr 11;14(8). Epub 2022 Apr 11.

Department of Surgery, Philipps-University, 35041 Marburg, Germany.

Aim: The aim of this research was to evaluate the long-term outcome of pancreaticoduodenectomy (PD) versus other duodenopancreatic resections (non-PD) for the surgical treatment of the Zollinger-Ellison syndrome (ZES) in patients with multiple endocrine neoplasia type 1 (MEN1).

Methods: Prospectively recorded patients with biochemically confirmed MEN1-ZES who underwent duodenopancreatic surgery were retrospectively analyzed in terms of clinical characteristics, complications, cure rate, and long-term morbidity, including quality of life assessment (EORTC QLQ-C30).

Results: 35 patients (16 female, 19 male) with MEN1-ZES due to duodenopancreatic gastrinomas with a median age of 42 (range 30-74) years were included. Read More

View Article and Full-Text PDF

Gastric neuroendocrine neoplasms: a primer for radiologists.

Abdom Radiol (NY) 2022 Apr 12. Epub 2022 Apr 12.

Department of Radiology, Michigan Medicine, University of Michigan, 1500 East Medical Center Drive, B1D502, Ann Arbor, MI, 48109, USA.

Gastric neuroendocrine neoplasms are uncommon tumors with variable differentiation and malignant potential. Three main subtypes are recognized: type 1, related to autoimmune atrophic gastritis; type 2, associated with Zollinger-Ellison and MEN1 syndrome; and type 3, sporadic. Although endoscopy alone is often sufficient for diagnosis and management of small, indolent, multifocal type 1 tumors, imaging is essential for evaluation of larger, high-grade, and type 2 and 3 neoplasms. Read More

View Article and Full-Text PDF

Primary Hepatic Neuroendocrine Tumor: A Case Report and Literature Review.

Cureus 2022 Feb 18;14(2):e22370. Epub 2022 Feb 18.

Internal Medicine, Faculty of Medicine, The University of Jordan, Amman, JOR.

Primary hepatic neuroendocrine tumors (PHNETs) are an utterly rare subtype of neuroendocrine tumors (NETs) that arise from cells of the neuroendocrine system. Due to the rarity and lack of distinctive radiological features, diagnosis and management of this tumor are challenging. Herein, we report a case of PHNET in a 19-year-old previously healthy female patient whose diagnosis was confirmed by histopathology and immunohistochemistry. Read More

View Article and Full-Text PDF
February 2022

Gastroesophageal Reflux Disease and the Zollinger-Ellison Syndrome.

Am J Gastroenterol 2022 06 28;117(6):1012-1013. Epub 2022 Mar 28.

Section of Gastroenterology, Veterans Administration San Diego Healthcare System, La Jolla, California, USA.

View Article and Full-Text PDF

Vitamin B12 absorption and malabsorption.

Vitam Horm 2022 1;119:241-274. Epub 2022 Mar 1.

Department of Internal Medicine, Division of Gastroenterology, Washington University School of Medicine, St Louis, MO, United States. Electronic address:

Vitamin B12 is assimilated and transported by complex mechanisms that involve three transport proteins, intrinsic factor (IF), haptocorrin (HC) and transcobalamin (TC) and their respective membrane receptors. Vitamin deficiency is mainly due to inadequate dietary intake in vegans, and B12 malabsorption is related to digestive diseases. This review explores the physiology of vitamin B12 absorption and the mechanisms and diseases that produce malabsorption. Read More

View Article and Full-Text PDF

Persistent gastrointestinal bleeding: a diagnostic challenge.

Rev Esp Enferm Dig 2022 Mar 8. Epub 2022 Mar 8.

Aparato Digestivo, Hospital Universitario Virgen Macarena, España.

Zollinger Ellison syndrome is an unusual entity. This termn is used to describe the clinical manifestations of a gastrin-synthesizing neoplasm. Gastrinomas occur mainly in the duodenum and pancreas. Read More

View Article and Full-Text PDF

Conjunctival myxoid stromal tumor of the palpebral conjunctiva: A case report.

Am J Ophthalmol Case Rep 2022 Jun 18;26:101427. Epub 2022 Feb 18.

North Florida / South Georgia Veterans Health System, 1601 SW Archer Rd., Gainesville, FL, 32608, USA.

Purpose: To present the importance of considering conjunctival myxoid stromal tumors in the differential when evaluating eyelid lesions as these tumors could indicate undetected systemic syndromes including Zollinger-Ellison Syndrome, Carney complex, and other endocrine disorders.

Observations: We present the case of a 56-year-old Caucasian female who was evaluated for a solid cyst-like structure of the palpebral conjunctiva just temporal to, but not involving, the left lower eyelid punctum. The lesion was removed with histopathologic examination of the specimen revealing the lesion to be a myxoid spindle cell tumor, consistent with conjunctival myxoid stromal tumor. Read More

View Article and Full-Text PDF

A case of enterochromaffin-like cell neuroendocrine tumor associated with parietal cell dysfunction which was successfully treated with somatostatin analogue.

Clin J Gastroenterol 2022 Apr 4;15(2):363-367. Epub 2022 Jan 4.

Department of Gastroenterology and Hepatology, Kurashiki Central Hospital, 1-1-1 Miwa, Kurashiki, Okayama, 710-8602, Japan.

We report here a case of a 62-year-old woman with multiple gastric enterochromaffin-like cell neuroendocrine tumor caused by hypergastrinemia due to parietal cell dysfunction that was successfully treated with somatostatin analogue. Esophagogastroduodenoscopy revealed several G1 neuroendocrine tumors, 10 mm in diameter, in the body of the stomach. No evidence of autoimmune gastritis, Helicobacter pylori infection, neuroendocrine neoplasia type 1, or Zollinger-Ellison syndrome was identified. Read More

View Article and Full-Text PDF

Secretin Stimulation Test and Early Diagnosis of Gastrinoma in MEN1 Syndrome: Survey on the MEN1 Florentine Database.

J Clin Endocrinol Metab 2022 04;107(5):e2110-e2123

F.I.R.M.O. Italian Foundation for Research on Bone Diseases, Florence, Italy.

Context: Multiple endocrine neoplasia type 1 (MEN1) is a rare inherited endocrine cancer syndrome. Multiple gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs) affect 30% to 80% of MEN1 patients, with the most common functioning GEP-NET being gastrinoma. Biochemical identification of hypergastrinemia may help to recognize the presence of gastrinomas before they are detectable by instrumental screening, enabling early diagnosis and start of therapy, preferably before tumor progression and metastases occurrence. Read More

View Article and Full-Text PDF

Primary thoracic gastrinoma causing Zollinger-Ellison syndrome.

Indian J Thorac Cardiovasc Surg 2021 Nov 9;37(6):706-709. Epub 2021 Jun 9.

General Surgery Ward, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

Gastrinomas are located largely in the pancreaticoduodenal region. However, gastrinomas have also been found in non-pancreaticoduodenal regions. Our study is a rare report of gastrinomas within the thoracic cavity. Read More

View Article and Full-Text PDF
November 2021

Somatostatin analogs in patients with Zollinger Ellison syndrome (ZES): an observational study.

Endocrine 2022 Mar 29;75(3):942-948. Epub 2021 Oct 29.

Division of Gastroenterology, Department of Medicine and Surgery, University of Milano-Bicocca, San Gerardo School of Medicine, Monza, Italy.

Purpose: Zollinger Ellison syndrome (ZES) is a rare syndrome caused by gastrin hypersecretion from a gastrinoma. Gastrinoma treatment has two goals: the control of acid hypersecretion and the control of tumor growth. While therapy for the syndrome is univocally based on proton pump inhibitors, the one for disease control is still debated. Read More

View Article and Full-Text PDF

[Comparison of clinical characteristics between sporadic gastrinoma and multiple endocrine neoplasia type 1-related gastrinoma].

Zhonghua Wei Chang Wai Ke Za Zhi 2021 Oct;24(10):875-882

Department of Gastroenterology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China Chen Jie now is working at the Center for Neuroendocrine Tumors, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai Pancreatic Cancer Institute, Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China.

To compare clinical characteristics of sporadic gastrinoma and multiple endocrine neoplasia type 1 (MEN1)-related gastrinoma. A retrospective cohort study was conducted. Patients with clinical manifestations of Zollinger-Ellison syndrome, pathological diagnosis as neuroendocrine neoplasm (NEN) and complete clinical and follow-up data were enrolled. Read More

View Article and Full-Text PDF
October 2021

Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies.

World J Gastroenterol 2021 Sep;27(35):5890-5907

Division of Gastroenterology and Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milano-Bicocca, Monza 20900, Italy.

Zollinger-Ellison syndrome (ZES) associated with pancreatic or duodenal gastrinoma is characterized by gastric acid hypersecretion, which typically leads to gastroesophageal reflux disease, recurrent peptic ulcers, and chronic diarrhea. As symptoms of ZES are nonspecific and overlap with other gastrointestinal disorders, the diagnosis is often delayed with an average time between the onset of symptoms and final diagnosis longer than 5 years. The critical step for the diagnosis of ZES is represented by the initial clinical suspicion. Read More

View Article and Full-Text PDF
September 2021

Validity of Secretin Stimulation Testing on Proton Pump Inhibitor Therapy for Diagnosis of Zollinger-Ellison Syndrome.

Am J Gastroenterol 2021 11;116(11):2216-2221

Digestive Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Introduction: Zollinger-Ellison syndrome (ZES) is characterized by gastrinoma-induced hypergastrinemia causing excessive gastric acid secretion. Secretin stimulation tests (SSTs) are required for diagnosis in the majority of patients. Two case reports suggest that proton pump inhibitors (PPIs) cause false SST results. Read More

View Article and Full-Text PDF
November 2021

Benign Oesophageal Stricture and Chronic Diarrhoea As Atypical Presenting Symptoms of an Advanced Metastatic Pancreatic Gastrinoma: A Case Report and Review of Literature.

Cureus 2021 Jul 23;13(7):e16593. Epub 2021 Jul 23.

Gastroenterology, United Lincolnshire Hospitals National Health Service (NHS) Trust, Boston, GBR.

Gastrinoma or otherwise known as Zollinger-Ellison syndrome is characterised by hypersecretion of gastrin and gastric acid leading to the formation of recurrent atypical ulcers along the upper gastrointestinal tract. It is extremely difficult to diagnose during an acute presentation both due to its rarity and its lack of pathognomonic symptoms. Its symptoms range from mild to severe to life-threatening and often get mistaken for a different condition such as viral gastroenteritis as seen in our case report. Read More

View Article and Full-Text PDF

Successful endoscopic resection of an unusually enlarged and pedunculated type I gastric carcinoid tumour.

BMJ Case Rep 2021 Aug 19;14(8). Epub 2021 Aug 19.

Department of Gastroenterology, Detroit Medical Center, Detroit, Michigan, USA.

Three distinct gastric carcinoid (GC) tumour types have been described based on differing biological behaviour and prognoses. Type I GC tumours account for the vast majority (70%-80%), are associated with chronic atrophic gastritis and have a low metastatic potential. Type II carcinoid tumours are the least common (5%-10%), are related to Zollinger-Ellison syndrome and occur in relation to multiple neoplasia type I. Read More

View Article and Full-Text PDF

Hypertrophic Gastric folds with Hypomagnesemia, linking the dots.

Pak J Med Sci 2021 Jul-Aug;37(4):1237-1240

Dr. Muhammad Toqeer, MBBS, FCPS (Pakistan), MRCP (UK). Consultant Gastroenterology. Conquest Hospital. East Sussex Healthcare, NHS Trust. TN37 7RD, UK.

A Caucasian man in early 80s was seen in Gastroenterology Clinic, following, referral from the Endocrinology Clinic for concerns for CT Abdomen requested for tiredness and weight loss of three kilograms. The patient also had microcytic picture with low MCV and Ferritin and hypomagnesemia. The CT suggested gross circumferential thickening of the wall of stomach with advice for invasive investigations to further characterise the CT findings. Read More

View Article and Full-Text PDF
December 2020

Enterochromaffin-like Cell Hyperplasia-Associated Gastric Neuroendocrine Tumors May Arise in the Setting of Proton Pump Inhibitor Use.

Arch Pathol Lab Med 2022 03;146(3):366-371

From the Departments of Pathology and Immunology (Rais, Chatterjee), Washington University in St. Louis, St. Louis, Missouri.

Context.—: Hypergastrinemia states such as achlorhydria from gastric mucosal atrophy or a gastrin-producing tumor in humans have been associated with the development of enterochromaffin-like (ECL) cell hyperplasia and gastric neuroendocrine tumors (GNETs). Whether drugs that can elevate serum gastrin levels, such as proton pump inhibitors (PPIs), can produce the same tissue effect is not known, and there is no concrete evidence linking the use of PPIs to GNETs outside animal models and case reports. Read More

View Article and Full-Text PDF

Postsurgical Presentation of Zollinger-Ellison Syndrome After Resection of Endometrioid Neuroendocrine Tumor.

ACG Case Rep J 2021 May 11;8(5):e00562. Epub 2021 May 11.

Division of Gastroenterology, Washington University School of Medicine in St. Louis, St. Louis, MO.

Zollinger-Ellison syndrome is a functional neuroendocrine tumor with inappropriate gastrin secretion and hyperchlorhydria causing severe peptic ulcer disease and chronic diarrhea. Although 70% of primary gastrinomas occur in the region of the duodenum, the diagnosis and localization of gastrinomas can be challenging because of small lesions that may arise functionally as lymph node metastases at initial presentation. We report a 76-year-old woman presenting with Zollinger-Ellison syndrome several months after surgical resection of endometrioid small cell neuroendocrine carcinoma and endometrioid adenocarcinoma. Read More

View Article and Full-Text PDF

Pancreatoduodenectomy for Neuroendocrine Tumors in Patients with Multiple Endocrine Neoplasia Type 1: An AFCE (Association Francophone de Chirurgie Endocrinienne) and GTE (Groupe d'étude des Tumeurs Endocrines) Study.

World J Surg 2021 06 1;45(6):1794-1802. Epub 2021 Mar 1.

Department of Digestive and Endocrine Surgery, Dijon University Hospital, University of Burgundy, Dijon, France.

Aim: To assess postoperative complications and control of hormone secretions following pancreatoduodenectomy (PD) performed on multiple endocrine neoplasia type 1 (MEN1) patients with duodenopancreatic neuroendocrine tumors (DP-NETs).

Background: The use of PD to treat MEN1 remains controversial, and evaluating the right place of PD in MEN1 disease makes sense.

Methods: Thirty-one MEN1 patients from the Groupe d'étude des Tumeurs Endocrines MEN1 cohort who underwent PD for DP-NETs between 1971 and 2013 were included. Read More

View Article and Full-Text PDF

Somatostatin receptor molecular imaging in a misdiagnosed gastrinoma case.

World J Nucl Med 2020 Oct-Dec;19(4):417-420. Epub 2020 Aug 22.

Department of Biophysics and Medical Physics, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania.

Gastrin-secreting tumors, hypergastrinemia and severe ulcer disease form the trademarks of Zollinger-Ellison syndrome (ZES). We report a case of gastrinoma, in a patient who was misdiagnosed for almost five years. The case emphsizes the the special role of functional imaging in the personalized approach to the patient with suggestive symptomatology for NETs. Read More

View Article and Full-Text PDF

Adverse Effects Associated with Proton Pump Inhibitor Use.

Cureus 2021 Jan 18;13(1):e12759. Epub 2021 Jan 18.

Internal Medicine, Dr Juan A. Fernández Hospital, Buenos Aires, ARG.

Proton pump inhibitors (PPIs) marked a before and after in the management of gastric acid-related disorders since their introduction to the market in 1989. Due to a novel, highly effective mechanism of action blocking the last converging step of gastric acid secretion by parietal cells and very few and mostly tolerable side effects, these drugs quickly displaced other pharmacological compounds such as H2 antagonists as the first treatment choice for peptic ulcer disease, gastroesophageal ulcers, Zollinger-Ellison syndrome, nonsteroidal anti-inflammatory drug-associated ulcers, and eradication of Helicobacter pylori, leading to an exponential increase in their prescription up to now. However, widespread PPI use has led to emerging evidence of long-term adverse effects not described previously, including increased risk of kidney, liver, and cardiovascular disease, dementia, enteroendocrine tumors of the gastrointestinal tract, susceptibility to respiratory and gastrointestinal infections, and impaired absorption of nutrients. Read More

View Article and Full-Text PDF
January 2021

Primary hyperparathyroidism and Zollinger Ellison syndrome during pregnancy: a case report.

Endocrinol Diabetes Metab Case Rep 2021 Feb 17;2021. Epub 2021 Feb 17.

St. Vincent's University Hospital, Dublin, Ireland.

Summary: Multiple endocrine neoplasia type 1 (MEN1) is a rare inherited endocrine disorder with a high rate of penetrance. The incidence of MEN1 is 1/30,000 in the general population; however, it is quite rare for a patient to present for medical attention with MEN1 for the first time in pregnancy. Primary hyperparathyroidism (PHPT) is one of the most common features of MEN1. Read More

View Article and Full-Text PDF
February 2021

Metastatic Gastrinoma Localized on Gallium-68 DOTATATE Imaging.

Mayo Clin Proc 2021 02;96(2):285-286

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.

View Article and Full-Text PDF
February 2021

Gastric enterochromaffin-like cell changes in multiple endocrine neoplasia type 1.

Clin Endocrinol (Oxf) 2021 09 7;95(3):439-446. Epub 2021 Feb 7.

Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Marburg, Germany.

Background: Gastric enterochromaffin-like cell (ECL) tumours can occur in patients with multiple endocrine neoplasia type 1 (MEN1), especially in those affected by Zollinger Ellison syndrome (ZES). Since the prevalence of ECL lesions is not well defined yet, the present study evaluated the presence and extent of ECL lesions in MEN1 patients with and without ZES.

Methods: Multiple endocrine neoplasia type 1 patients being part of a regular screening program (2014-2018) underwent gastroduodenoscopies with biopsies of the stomach and determination of serum gastrin and chromogranin A levels. Read More

View Article and Full-Text PDF
September 2021

Acute oesophageal necrosis in multiple endocrine neoplasia type 1: an undescribed complication.

BMJ Case Rep 2021 Jan 7;14(1). Epub 2021 Jan 7.

Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Acute oesophageal necrosis (AEN) is a rare entity that most commonly presents as upper gastrointestinal bleeding. Complex pathophysiology may include oesophageal ischaemia as well as reflux of acidic gastric contents causing oesophageal mucosal injury. Management is supportive and directed at underlying comorbidities however prognosis is poor with complications such as oesophageal perforation, stricture and stenosis. Read More

View Article and Full-Text PDF
January 2021