3,580 results match your criteria Zollinger-Ellison Syndrome


Delayed Management of Zollinger-Ellison Syndrome in a Noncompliant Patient.

Cureus 2020 Jun 6;12(6):e8471. Epub 2020 Jun 6.

Department of Gastroenterology and Hepatology, Carol Davila University of Medicine and Pharmacy, Floreasca Emergency Hospital, Bucharest, ROU.

We present a case of a 60-year-old male diagnosed with Zollinger-Ellison syndrome (ZES) after a protracted multicentric workup for chronic diarrhea and unexplained weight loss. ZES is intrinsically difficult to diagnose due to nonspecific symptoms, which are mimicked by other more frequent pathologies, such as peptic ulcer disease secondary to Helicobacter pylori or nonsteroidal anti-inflammatory drugs. The diagnostic challenge can be further complicated by patient noncompliance, resulting in delayed management and unnecessary health care. Read More

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http://dx.doi.org/10.7759/cureus.8471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336717PMC

De novo Gastrinoma: A Case Report.

GE Port J Gastroenterol 2020 Apr 9;27(3):192-196. Epub 2019 Oct 9.

Internal Medicine Department, Centro Hospitalar São João, Porto, Portugal.

Gastrinomas are neuroendocrine tumors characterized by gastrin overexpression - 80% are sporadic and 20% are associated with multiple endocrine neoplasia type 1. A 75-year-old male patient, surgically treated at the age of 50 years for gastrinoma, followed on an outpatient basis because of chronic non-bloody diarrhea, was admitted to our hospital because of abdominal pain, watery diarrhea, and nonbiliary vomits. He was hypotensive and showed no response to fluids. Read More

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http://dx.doi.org/10.1159/000503073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250327PMC

The Neuroendocrine Neoplasms of the Digestive Tract: Diagnosis, Treatment and Nutrition.

Nutrients 2020 May 15;12(5). Epub 2020 May 15.

Department of Human Nutrition and Metabolomic, Pomeranian Medical University in Szczecin, Broniewskiego 24 str, 71-460 Szczecin, Poland.

Nuroendocrine neoplasms (NENs) are a group of rare neoplasms originating from dispersed neuroendocrine cells, mainly of the digestive and respiratory tract, showing characteristic histology and immunoprofile contributing to classification of NENs. Some NENs have the ability to produce biogenic amines and peptide hormones, which may be associated with clinical syndromes like, e.g. Read More

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http://dx.doi.org/10.3390/nu12051437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284837PMC

Cytopathological evaluation of potential malignancy of duodenal gastrinoma using aspiration smears from two patients' resected tumors (NET G1, NET G2): A case report.

Mol Clin Oncol 2020 Jun 10;12(6):592-596. Epub 2020 Apr 10.

Department of Pathology, Amagasaki Chuo Hospital, Amagasaki, Hyogo 661-0976, Japan.

Sporadic gastrin-producing neuroendocrine tumors (NETs) of the duodenum present with either Zollinger-Ellison syndrome or unspecific syndromes. Ki-67 scoring in cytopathology is an alternative approach for establishing the gastrinoma grade. Although the majority of NETs, including gastrinomas, occur in the duodenum, most research regarding the Ki-67 index is focused on tumors of pancreatic origin. Read More

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http://dx.doi.org/10.3892/mco.2020.2030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179385PMC

Management of Other Gastric and Duodenal Neuroendocrine Tumors.

Surg Oncol Clin N Am 2020 Apr;29(2):253-266

Section of Endocrine Surgery, Rutgers Cancer Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, NJ 08903, USA.

Gastric and duodenal neuroendocrine tumors (NETs) are increasing in incidence as a result of increased detection and awareness of neuroendocrine tumors as distinct tumor types. The three types of gastric NETs and duodenal NETs have different etiologies and tumor-specific factors, such as grade, location, and hormone-production, and the clinical settings influence management. Options for treatment include removal by local endoscopic resection and surgical resection. Read More

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http://dx.doi.org/10.1016/j.soc.2019.11.009DOI Listing

Manifestation of Zollinger-Ellison Syndrome With Hypovolemic Shock.

Am J Med 2020 Feb 19. Epub 2020 Feb 19.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1016/j.amjmed.2019.12.037DOI Listing
February 2020

Proton pump inhibitors from clinical pharmacists point of view.

Authors:
Alena Pilková

Cas Lek Cesk 2019 ;158(7-8):282-288

Proton pump inhibitors (PPIs) are very effective drugs in treatment and prevention of acid-related disorders. They are widely used in gastroesophageal reflux disease, gastroduodenal ulcers, Zollinger-Ellison syndrome or prevention and treatment of NSAIDs induced gastric lesions. They are also used in many other indications, although not always is their use appropriate. Read More

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February 2020

Proton Pump Inhibitor Use, Hypergastrinemia, and Gastric Carcinoids-What Is the Relationship?

Authors:
Denis M McCarthy

Int J Mol Sci 2020 Jan 19;21(2). Epub 2020 Jan 19.

Departments of Medicine & Biochemistry, Division of Gastroenterology and Hepatology, University of New Mexico School of Medicine and Raymond G. Murphy Veterans Administration Medical Center, 1501 San Pedro Blvd. SE, Albuquerque, NM 87108, USA.

Neuroendocrine tumors (NETs) throughout the body are the focus of much current interest. Most occur in the gastrointestinal tract and have shown a major increase in incidence over the past 30 years, roughly paralleling the world-wide increase in the use of proton pump inhibitor (PPI) drugs. The greatest rise has occurred in gastric carcinoids (g-NETs) arising from enterochromaffin-like (ECL) cells. Read More

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http://dx.doi.org/10.3390/ijms21020662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014182PMC
January 2020

Atypical Thymic Carcinoid in a Patient with Zollinger-Ellison Syndrome.

Korean J Thorac Cardiovasc Surg 2019 Dec 5;52(6):420-424. Epub 2019 Dec 5.

Department of Thoracic and Cardiovascular Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Atypical thymic carcinoid is an extremely rare tumor with a poor prognosis. In addition to its known association with multiple endocrine neoplasia type 1, its hallmark characteristics include local invasion and early distant metastasis. In this report, we share our experience treating atypical thymic carcinoid in a patient with Zollinger-Ellison syndrome. Read More

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http://dx.doi.org/10.5090/kjtcs.2019.52.6.420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901190PMC
December 2019

[Gastric neuroendocrine tumors].

Khirurgiia (Mosk) 2019 (12):111-120

Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia PA, USA.

Gastrointestinal neuroendocrine tumors are rare neoplasms. Currently, incidence of gastric neuroendocrine tumors (gNETs) is being significantly increased. There are 3 groups of gNETs: types I, II and III. Read More

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http://dx.doi.org/10.17116/hirurgia2019121111DOI Listing
December 2019

Roar Strøm - the Norwegian surgeon who was three years ahead of Zollinger and Ellison.

Tidsskr Nor Laegeforen 2019 Dec 9;139(18). Epub 2019 Dec 9.

Background: In 1952, Norwegian surgeon Roar Strøm (1903-58) published the medical history of a 32-year-old man with recurrent peptic ulcer disease and a pancreatic tumour. Three years later, two American surgeons described a similar condition and, only the following year, the condition was named after them: Zollinger-Ellison syndrome. Strøm's contribution has gone remarkably unrecognised. Read More

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http://dx.doi.org/10.4045/tidsskr.19.0292DOI Listing
December 2019

Zollinger-Ellison syndrome.

CMAJ 2019 Dec;191(49):E1358

Department of Medicine (Zimmer), Marienhausklinik St. Josef Kohlhof, Neunkirchen, Germany; Departments of Medicine II (Zimmer, Lammert) and General, Visceral, Vascular, and Pediatric Surgery (Glanemann), Saarland University Medical Center, Saarland University, Homburg, Germany.

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http://dx.doi.org/10.1503/cmaj.191047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901272PMC
December 2019

Case report: optimal tumor cytoreduction and octreotide with durable disease control in a patient with MEN-1 and Zollinger-Ellison syndrome-over a decade of follow-up.

World J Surg Oncol 2019 Dec 9;17(1):213. Epub 2019 Dec 9.

Department of Surgery, Drexel University College of Medicine, 245 N. 15th Street, Suite 7150, Philadelphia, PA, 19102, USA.

Background: Zollinger-Ellison syndrome (ZES) is a rare condition characterized by hypersecretion of gastrin by gastrinoma tumors leading to severe peptic ulcer disease with potential development of gastric carcinoid tumors. Herein, we report the clinical course of a 68-year-old patient with multiple endocrine neoplasia type 1 (MEN-1) who underwent several surgeries to ultimately undergo optimal tumor cytoreduction of locally advanced gastrinomas and symptomatic gastric carcinoids. The patient was subsequently maintained on octreotide long-acting release (LAR). Read More

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http://dx.doi.org/10.1186/s12957-019-1758-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902565PMC
December 2019

Diagnostic accuracy of selective arterial calcium injection test for localization of gastrinoma.

Endocr J 2020 Mar 7;67(3):305-315. Epub 2019 Dec 7.

Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

The appropriate localization of gastrinoma is still difficult. We aimed to evaluate the diagnostic accuracy of selective arterial calcium injection (SACI) for localization of gastrinomas including multiple lesions. This retrospective study included ten patients with surgically proven gastrinomas (gastrinoma group) and six patients without any findings suggesting Zollinger-Ellison syndrome (non-gastrinoma group). Read More

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http://dx.doi.org/10.1507/endocrj.EJ19-0413DOI Listing

The Pancreatic Endocrine Tumors - Experience of First Surgical Clinic Iasi.

Chirurgia (Bucur) 2019 Sept-Oct;114(5):639-649

Pancreatic neuroendocrine tumors (PNETs) are rare and characterized by widely variable clinical presentation and often challenging surgical management. Retrospective study conducted during the last 15 years at the First Surgical Clinic of the Iasi St Spiridon University Hospital, and which included all the patients diagnosed with pancreatic endocrine tumors by immunohistochemistry. There were 26 cases diagnosed with PNET. Read More

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http://dx.doi.org/10.21614/chirurgia.114.5.639DOI Listing
November 2019
1 Read

Insights into Effects/Risks of Chronic Hypergastrinemia and Lifelong PPI Treatment in Man Based on Studies of Patients with Zollinger-Ellison Syndrome.

Int J Mol Sci 2019 Oct 16;20(20). Epub 2019 Oct 16.

Digestive Diseases Branch, NIDDK, NIH, Bethesda, MD 20892-1804, USA.

The use of proton pump inhibitors (PPIs) over the last 30 years has rapidly increased both in the United States and worldwide. PPIs are not only very widely used both for approved indications (peptic ulcer disease, gastroesophageal reflux disease (GERD), Helicobacter pylori eradication regimens, stress ulcer prevention), but are also one of the most frequently off-label used drugs (25-70% of total). An increasing number of patients with moderate to advanced gastroesophageal reflux disease are remaining on PPI indefinitely. Read More

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http://dx.doi.org/10.3390/ijms20205128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829234PMC
October 2019
1 Read

Occurrence of Acute Oesophageal Necrosis (Black Oesophagus) in a Single Tertiary Centre.

J Clin Med 2019 09 24;8(10). Epub 2019 Sep 24.

Medical-Surgical Department of Clinical Sciences and Translational Medicine, Sant'Andrea Hospital, University Sapienza, 00189 Rome, Italy.

Acute oesophageal necrosis (AON) is a rare condition characterised by the endoscopic finding of diffuse, circumferential, black mucosal pigmentation of the oesophagus, which typically stops at the gastro-oesophageal junction. This observational study aimed to assess the occurrence, clinical characteristics and outcomes of AON in a consecutive endoscopic cohort in a single tertiary university centre. A retrospective analysis of endoscopic data of upper gastrointestinal endoscopy (UGE) was carried out from 2008 to 2018. Read More

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http://dx.doi.org/10.3390/jcm8101532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832419PMC
September 2019
3 Reads

Surgical management of Zollinger-Ellison syndrome: Classical considerations and current controversies.

World J Gastroenterol 2019 Aug;25(32):4673-4681

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing 100730, China.

Zollinger-Ellison syndrome (ZES) is characterized by gastric acid hypersecretion causing severe recurrent acid-related peptic disease. Excessive secretion of gastrin can now be effectively controlled with powerful proton pump inhibitors, but surgical management to control gastrinoma itself remains controversial. Based on a thorough literature review, we design a surgical algorithm for ZES and list some significant consensus findings and recommendations: (1) For sporadic ZES, surgery should be routinely undertaken as early as possible not only for patients with a precisely localized diagnosis but also for those with negative imaging findings. Read More

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http://dx.doi.org/10.3748/wjg.v25.i32.4673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718045PMC
August 2019
4 Reads

Contemporary surgical management of the Zollinger-Ellison syndrome in multiple endocrine neoplasia type 1.

Best Pract Res Clin Endocrinol Metab 2019 10 31;33(5):101318. Epub 2019 Aug 31.

Department of Visceral, Thoracic, and Vascular Surgery, Philipps University Marburg, Baldingerstr, 35037 Marburg, Germany.

About 30% of patients with MEN1 develop a Zollinger-Ellison syndrome. Meanwhile it is well established that the causative gastrinomas are almost exclusively localized in the duodenum and not in the pancreas, MEN1 gastrinomas occur multicentric and are associated with hyperplastic gastrin cell lesions and tiny gastrin-producing micro tumors in contrast to sporadic duodenal gastrinomas. Regardless of the high prevalence of early lymphatic metastases, the survival is generally good with an aggressive course of disease in only about 20% of patients. Read More

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http://dx.doi.org/10.1016/j.beem.2019.101318DOI Listing
October 2019
2 Reads

Low-Value Proton Pump Inhibitor Prescriptions Among Older Adults at a Large Academic Health System.

J Am Geriatr Soc 2019 12 5;67(12):2600-2604. Epub 2019 Sep 5.

Division of Geriatrics, David Geffen School of Medicine at UCLA and Veterans Affairs (VA) Greater Los Angeles Healthcare System Geriatric Research Education and Clinical Center, Los Angeles, California.

Background: Older adults are particularly vulnerable to complications from proton pump inhibitor (PPI) drugs. We sought to characterize the prevalence of potentially low-value PPI prescriptions among older adults to inform a quality improvement (QI) intervention.

Methods: We created a cohort of patients, aged 65 years or older, receiving primary care at a large academic health system in 2018. Read More

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http://dx.doi.org/10.1111/jgs.16117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952216PMC
December 2019
2 Reads

Prognostic factors and survival in MEN1 patients with gastrinomas: Results from the DutchMEN study group (DMSG).

J Surg Oncol 2019 Nov 10;120(6):966-975. Epub 2019 Aug 10.

Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.

Background And Objectives: Gastrinomas are the most prevalent functioning neuroendocrine tumors (NET) in multiple endocrine neoplasia type 1 (MEN1). Guidelines suggest medical therapy in most patients, but surgery may be considered in a subgroup. Currently, factors to guide management are necessary. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jso.25667
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http://dx.doi.org/10.1002/jso.25667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852496PMC
November 2019
5 Reads

Zollinger Ellison Syndrome in a Patient with Multiple Endocrine Neoplasia Type 1: A Classic Presentation.

Case Rep Gastrointest Med 2019 3;2019:9605769. Epub 2019 Jun 3.

Department of Gastroenterology, Creighton University St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.

Zollinger Ellison Syndrome (ZES) is characterized by a wide spectrum of conditions including severe gastroesophageal reflux disease, peptic ulcer disease, watery diarrhea, and weight loss. We present a case of a 60-year-old woman being evaluated for severe dyspepsia, vomiting, and chronic diarrhea, who was diagnosed to have ZES associated with a pancreatic neuroendocrine tumor, in the setting of multiple endocrine neoplasia (MEN) type 1. Although cases of ZES have been reported previously, we believe that our case is a classic presentation of ZES diagnosed on the basis of typical radiologic, endoscopic, and endosonographic features. Read More

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http://dx.doi.org/10.1155/2019/9605769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582874PMC
June 2019
6 Reads

The Gastrinoma Saga Before Zollinger and Ellison: The Strøm Case Revisited.

Ann Surg 2019 08;270(2):e19-e21

Department of Clinical Medicine, University of Bergen, Bergen, Norway.

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http://dx.doi.org/10.1097/SLA.0000000000003261DOI Listing
August 2019
2 Reads

VISUAL VIGNETTE.

Endocr Pract 2020 03 23;26(3):362. Epub 2019 Apr 23.

From the Imperial Centre for Endocrinology, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.

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http://dx.doi.org/10.4158/EP-2019-0124DOI Listing
March 2020
6 Reads

Classical features of Zollinger-Ellison syndrome, in images.

Gastrointest Endosc 2019 06 5;89(6):1255-1257. Epub 2019 Feb 5.

Department of Gastroenterology and Advanced Endoscopy, Western Regional Medical Center, Cancer Treatment Centers of America, Goodyear, Arizona, USA.

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http://dx.doi.org/10.1016/j.gie.2019.01.026DOI Listing
June 2019
18 Reads

A Young Man With Abdominal Pain, Shock, and Respiratory Distress.

Chest 2018 11;154(5):e119-e121

Mount Sinai St. Luke's and Mount Sinai West; Icahn School of Medicine at Mount Sinai, New York, NY.

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https://linkinghub.elsevier.com/retrieve/pii/S00123692183241
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http://dx.doi.org/10.1016/j.chest.2018.06.044DOI Listing
November 2018
22 Reads

Management of Primary Lymph Nodal Gastrinoma With Liver Metastases Resulting in Zollinger-Ellison Syndrome.

Clin Nucl Med 2019 Jan;44(1):e36-e39

From the Departments of Nuclear Medicine.

Primary lymph node gastrinoma has been defined as gastrin-producing tumor present in lymph nodes and predominantly found in well-defined anatomical region known as gastrinoma triangle. They are usually localized preoperatively with imaging, and their surgical resection results in long-term relief. The authors report a case of unresectable primary lymph nodal gastrinoma with liver metastases in a 14-year-old adolescent boy with proven histopathology detected on Ga-DOTANOC whole-body PET/CT scan followed by preoperative multiple Lu-DOTATATE cycles for cytoreduction. Read More

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http://Insights.ovid.com/crossref?an=00003072-900000000-9736
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http://dx.doi.org/10.1097/RLU.0000000000002368DOI Listing
January 2019
41 Reads
3.931 Impact Factor

Gastrinoma of Cystic Duct: A Rare Association With Multiple Endocrine Neoplasia Type 1.

J Clin Med Res 2018 Nov 9;10(11):843-847. Epub 2018 Oct 9.

Department of Internal Medicine and Endocrine Unit, Medical School and Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Neuroendocrine tumors (NETs) of cystic duct are extremely rare, accounting for less than 2% of NET cases. The association of biliary tree NET and multiple endocrine neoplasm type 1 (MEN1) are even more rare. In this report, we described a case of a 65-year-old woman who was referred to our neuroendocrine outpatient clinic to investigate MEN1 after an incidental diagnosis of gastrinoma. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3541
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http://dx.doi.org/10.14740/jocmr3541wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188020PMC
November 2018
48 Reads

Proton pump inhibitors: use and misuse in the clinical setting.

Expert Rev Clin Pharmacol 2018 Nov 10;11(11):1123-1134. Epub 2018 Oct 10.

b Gastrointestinal Unit, Department of Surgery , Oncology and Gastroenterology, University of Padua , Padua , Italy.

Introduction: The introduction of proton pump inhibitors (PPIs) into clinical practice has greatly improved our therapeutic approach to acid-related diseases for their efficacy and safety. Areas Covered: The following evidence-based indications for PPI use are acknowledged by many scientific societies: treatment of the various forms and complications of gastroesophageal reflux disease, eradication of H. pylori infection in combination with two or more antibiotics, short- and long-term therapy of H. Read More

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https://www.tandfonline.com/doi/full/10.1080/17512433.2018.1
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http://dx.doi.org/10.1080/17512433.2018.1531703DOI Listing
November 2018
43 Reads

Results of Duodenopancreatic Reoperations in Multiple Endocrine Neoplasia Type 1.

World J Surg 2019 Feb;43(2):552-558

Department of Visceral-, Thoracic- and Vascular Surgery, Philipps University of Marburg, Baldingerstr, 35043, Marburg, Germany.

Background: To evaluate the outcome of duodenopancreatic reoperations in patients with multiple endocrine neoplasia type 1 (MEN1).

Methods: MEN1 patients who underwent reoperations for duodenopancreatic neuroendocrine neoplasms (dpNENs) were retrieved from a prospective database and retrospectively analyzed.

Results: Twelve of 101 MEN1 patients underwent up to three reoperations, resulting in a total of 18 reoperations for dpNEN recurrence. Read More

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http://link.springer.com/10.1007/s00268-018-4809-1
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http://dx.doi.org/10.1007/s00268-018-4809-1DOI Listing
February 2019
44 Reads

Multiple Endocrine Neoplasia Type 1: A Case Report With Review of Imaging Findings.

Ochsner J 2018 ;18(2):170-175

Department of Radiology, Ochsner Clinic Foundation, New Orleans, LA.

Background: Multiple endocrine neoplasia type 1 (MEN1) is a rare, autosomal dominant inherited syndrome caused by mutations in the MEN1 tumor suppressor gene. The diagnosis is defined clinically by the presence of 2 or more primary MEN1 tumors (parathyroid, anterior pituitary, and pancreatic islet). We describe the case of a patient who presented with classic history and imaging findings for MEN1. Read More

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http://dx.doi.org/10.31486/toj.17.0019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135292PMC
January 2018
16 Reads

Gastrinomas: Medical or Surgical Treatment.

Endocrinol Metab Clin North Am 2018 09;47(3):577-601

Digestive Diseases Branch, NIDDK, National Institutes of Health, Building 10, Room 9C-103, Bethesda, MD 20892-1804, USA. Electronic address:

This article reviews the role of surgical and medical management in patients with Zollinger-Ellison syndrome (ZES) due to a gastrin-secreting neuroendocrine tumor (gastrinoma). It concentrates on the status at present but also briefly reviews the changes over time in treatment approaches. Generally, surgical and medical therapy are complementary today; however, in some cases, such as patients with ZES and multiple endocrine neoplasia type 1, the treatment approach remains controversial. Read More

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http://dx.doi.org/10.1016/j.ecl.2018.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092039PMC
September 2018
35 Reads

Large primary hepatic gastrinoma in young patient treated with trisegmentectomy: A case report and review of the literature.

World J Hepatol 2018 Jul;10(7):517-522

Departamento de Gastroenterologia, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403, Brazil.

Primary hepatic gastrinoma is a rare disease, with fewer than 40 cases reported in the medical literature. Because it is located in an organ in which metastases are common, its diagnosis is difficult. We report a case of a 19 years old male patient with a history of gastric ulcers since the age of nine. Read More

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http://dx.doi.org/10.4254/wjh.v10.i7.517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068851PMC
July 2018
9 Reads

Bringing SASI back: Single session selective arterial secretin injection and transarterial embolization of intrahepatic pancreatic neuroendocrine metastasis in a MEN-1 patient.

Radiol Case Rep 2018 Apr 3;13(2):333-335. Epub 2018 Feb 3.

Department of Radiology, Division of Vascular and Interventional Radiology, University of Michigan Health Systems, 1500 East Medical Center Dr, Ann Arbor, MI 48109, USA.

SASI (selective arterial secretin injection) is a form of ASVS (arterial stimulation and venous sampling) used to localize pancreatic gastrinomas. This report aims to review the protocol for SASI and demonstrate its utility in localizing functional and nonfunctional gastrinomas. Even if a patient has a pancreatic mass and a laboratory profile fitting a specific endocrine syndrome, these may or may not be associated as has been previously demonstrated with adrenal vein sampling. Read More

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http://dx.doi.org/10.1016/j.radcr.2018.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000080PMC
April 2018
20 Reads

Gastrinoma and Zollinger-Ellison syndrome in canids: a literature review and a case in a Mexican gray wolf.

J Vet Diagn Invest 2018 Jul 2;30(4):584-588. Epub 2018 Jun 2.

Animal Health Institute, Department of Pathology and Population Medicine, Midwestern University, Glendale, AZ (Struthers, Wong).

Gastrinoma, an infrequent diagnosis in middle-aged dogs, occurs with nonspecific gastrointestinal morbidity. Laboratory tests can yield a presumptive diagnosis, but definitive diagnosis depends on histopathology and immunohistochemistry. We describe a malignant pancreatic gastrinoma with lymph node metastases and corresponding Zollinger-Ellison syndrome in a Mexican gray wolf ( Canis lupus baileyi) and review this endocrine neoplasm in domestic dogs. Read More

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http://dx.doi.org/10.1177/1040638718779638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505925PMC
July 2018
16 Reads

The appropriate use of proton-pump inhibitors.

Minerva Med 2018 Oct 31;109(5):386-399. Epub 2018 May 31.

Gastrointestinal Unit, Department of Surgery, Oncology, and Gastroenterology, University of Padua, Padua, Italy.

The introduction of proton-pump inhibitors (PPIs) into clinical practice since about thirty years has greatly improved our therapeutic approach to acid-related diseases for their well recognized efficacy and safety. Accordingly, the role of surgery has been enormously reduced in this field. The main indications for PPI use are universally acknowledged by many scientific societies and are the following: treatment of gastroesophageal reflux disease in its various forms and complications, eradication of H. Read More

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http://dx.doi.org/10.23736/S0026-4806.18.05705-1DOI Listing
October 2018
17 Reads

Management of functional neuroendocrine tumors of the pancreas.

Authors:
Kjell Öberg

Gland Surg 2018 Feb;7(1):20-27

Department of Medical Sciences, Endocrine Oncology, Uppsala University Hospital, Uppsala, Sweden.

Pancreatic neuroendocrine tumors (pNETs) constitute a heterogenous group of malignancies with varying clinical presentation, tumor biology and prognosis. The incidence of pNETs has steadily increased during the last decades with an estimated incidence 2012 of 4.8/100,000. Read More

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http://dx.doi.org/10.21037/gs.2017.10.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876681PMC
February 2018
48 Reads

Old and New Gut Hormone, Gastrin and Acid Suppressive Therapy.

Digestion 2018 27;97(4):340-344. Epub 2018 Mar 27.

Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School, Kurashiki, Japan.

Gastrin acts physiologically as a gut hormone to stimulate acid secretion after meal and as a cell-growth factor of oxyntic mucosa. Increase in serum gastrin level happens under various conditions including Zollinger-Ellison syndrome, antral G cell hyperplasia, autoimmune gastritis, atrophic gastritis, renal failure, vagotomy, Helicobacter pylori infection and acid suppressive therapy. As acid suppressive therapy causes hypergastrinemia, the association between acid suppressive therapy and gastric neuroendocrine cell tumor (NET) has been discussed during the past 30 years. Read More

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http://dx.doi.org/10.1159/000485734DOI Listing
September 2018
20 Reads

Prospective Evaluation of Results of Reoperation in Zollinger-Ellison Syndrome.

Ann Surg 2018 04;267(4):782-788

Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.

Objective: To determine the role of reoperation in patients with persistent or recurrent Zollinger-Ellison Syndrome (ZES).

Background: Approximately, 0% to 60% of ZES patients are disease-free (DF) after an initial operation, but the tumor may recur.

Methods: A prospective database was queried. Read More

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http://dx.doi.org/10.1097/SLA.0000000000002122DOI Listing
April 2018
40 Reads

A Rare Cause of Abdominal Pain and Mass in an 18-Year-Old Patient: A Diagnostic Dilemma.

Gastroenterology Res 2018 Feb 23;11(1):75-78. Epub 2018 Feb 23.

Department of Medicine, Bronx Lebanon Hospital Center, Bronx, NY 10457, USA.

We present a case of an 18-year-old male who presented with complains of abdominal pain, nausea and vomiting for 2 years. An esophagogastroduodenoscopy (EGD) revealed a 3 mm nodule on the lesser curvature of the stomach and prominent gastric folds. Biopsy of the nodule revealed a well-differentiated neuroendocrine tumor (NET) in lamina prop with focal extension into muscularis mucosa consistent with a gastric carcinoid. Read More

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http://dx.doi.org/10.14740/gr955wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827909PMC
February 2018
20 Reads

Introduction and practical approach to exocrine pancreatic insufficiency for the practicing clinician.

Int J Clin Pract 2018 Feb 5;72(2). Epub 2018 Feb 5.

Division of Gastroenterology, Department of Medicine, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.

Aims: In exocrine pancreatic insufficiency (EPI), the quantity and/or activity of pancreatic digestive enzymes are below the levels required for normal digestion, leading to maldigestion and malabsorption. Diagnosis of EPI is often challenging because the characteristic signs and symptoms overlap with those of other gastrointestinal conditions. Additionally, there is no single convenient, or specific diagnostic test for EPI. Read More

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http://dx.doi.org/10.1111/ijcp.13066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873407PMC
February 2018
22 Reads

Incidence and Prognosis of Primary Gastrinomas in the Hepatobiliary Tract.

JAMA Surg 2018 03;153(3):e175083

Digestive Diseases Branch, National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland

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http://dx.doi.org/10.1001/jamasurg.2017.5083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885930PMC
March 2018
15 Reads

Diagnosis of Zollinger-Ellison syndrome in the era of PPIs, faulty gastrin assays, sensitive imaging and limited access to acid secretory testing.

Int J Endocr Oncol 2017 11;4(4):167-185. Epub 2017 Oct 11.

Digestive Diseases Branch, NIDDK, NIH, Bethesda, Maryland, 20817, USA.

In recent years the diagnosis of Zollinger-Ellison syndrome (ZES) has become increasingly controversial with several new approaches and criteria proposed, differing from the classical biochemical criterion of inappropriate hypergastrinemia (i.e., hypergastrinemia in the presence of hyperchlorhydria) (Table 1). Read More

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http://dx.doi.org/10.2217/ije-2017-0018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757869PMC
October 2017
20 Reads

Going from A to Z.

N Engl J Med 2018 01;378(1):73-79

From the Department of Medicine, Johns Hopkins Hospital and Johns Hopkins University School of Medicine, Baltimore (D.A., D.F., R.M.); and the Department of Medicine, University of California, San Francisco, and the Medical Service, San Francisco Veterans Affairs Medical Center - both in San Francisco (G.D., K.R.F.).

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http://dx.doi.org/10.1056/nejmcps1701264DOI Listing
January 2018
33 Reads

[Functional diagnostics in endocrinology].

Internist (Berl) 2018 01;59(1):38-47

Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Campus Innenstadt, Ziemssenstraße 1, 80366, München, Deutschland.

When investigating many endocrinological diseases, basal laboratory parameters are not sufficient to distinguish between physiological and pathological hormone secretion. Functional diagnostics plays a decisive role in this context. Stimulation and suppression tests are used depending on whether under- or over-function needs to be diagnosed. Read More

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http://dx.doi.org/10.1007/s00108-017-0360-7DOI Listing
January 2018
16 Reads

Hormone secreting gastro-entero-pancreatic neuroendocrine neoplasias (GEP-NEN): When to consider, how to diagnose?

Rev Endocr Metab Disord 2017 12;18(4):393-410

Schwerpunkt Endokrinologie und Stoffwechselerkrankungen, I. Medizinischen Klinik und Poliklinik; ENETS center of excellence, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Langenbeckstrasse 1, 55101, Mainz, Germany.

Neuroendocrine neoplasms of the digestive system (GEP-NEN) represent a heterogeneous group of malignancies with various clinical presentation and prognosis. GEP-NENs can potentially affect all organs of the gastrointestinal tract; characteristically they share the biological property to produce and secrete peptides and neuroamines. About 30% of GEP-NENs are hormonally active and can cause specific clinical syndromes. Read More

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http://dx.doi.org/10.1007/s11154-017-9438-8DOI Listing
December 2017
27 Reads