117 results match your criteria Zipper Injuries


Response to metals treatment of Fra1, a member of the AP-1 transcription factor family, in P. lividus sea urchin embryos.

Mar Environ Res 2018 Aug 5;139:99-112. Epub 2018 May 5.

Consiglio Nazionale delle Ricerche, Istituto di Biomedicina e Immunologia Molecolare "A. Monroy", Via Ugo La Malfa 153, 90146, Palermo, Italy. Electronic address:

Lithium (Li), Nickel (Ni), and Zinc (Zn) are metals normally present in the seawater, although they can have adverse effects on the marine ecosystem at high concentrations by interfering with many biological processes. These metals are toxic for sea urchin embryos, affecting their morphology and developmental pathways. In particular, they perturb differently the correct organization of the embryonic axes (animal-vegetal, dorso-ventral): Li is a vegetalizing agent and Ni disrupts the dorso-ventral axis, while Zn has an animalizing effect. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01411136173070
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http://dx.doi.org/10.1016/j.marenvres.2018.05.003DOI Listing
August 2018
7 Reads

Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury.

Exp Eye Res 2018 06 8;171:54-61. Epub 2018 Mar 8.

Shiley Eye Institute, University of California, La Jolla, San Diego, CA 92037, USA. Electronic address:

Optic neuropathies such as glaucoma are characterized by the degeneration of retinal ganglion cells (RGCs) and the irreversible loss of vision. In these diseases, focal axon injury triggers a propagating axon degeneration and, eventually, cell death. Previous work by us and others identified dual leucine zipper kinase (DLK) and JUN N-terminal kinase (JNK) as key mediators of somal cell death signaling in RGCs following axonal injury. Read More

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http://dx.doi.org/10.1016/j.exer.2018.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964014PMC
June 2018
8 Reads

Genetic identification and molecular modeling characterization reveal a novel mutation in Stargardt4-like macular dystrophy.

Oncotarget 2018 Jan 9;9(1):122-141. Epub 2017 Nov 9.

Hunan Normal University Medical College, Changsha, Hunan, China.

Stargardt disease-4 (STGD4) is an autosomal dominant complex, genetically heterogeneous macular degeneration/dystrophy (MD) disorder. In this paper, we used targeted next generation sequencing and multiple molecular dynamics analyses to identify and characterize a disease-causing genetic variant in four generations of a Chinese family with STGD4-like MD. We found a novel heterozygous missense mutation, c. Read More

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787432/
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http://europepmc.org/articles/PMC5787432
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http://www.oncotarget.com/fulltext/22343
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http://dx.doi.org/10.18632/oncotarget.22343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787432PMC
January 2018
11 Reads

Prickle1 as positive regulator of oligodendrocyte differentiation.

Neuroscience 2017 Nov 19;364:107-121. Epub 2017 Sep 19.

Neurogenomics Laboratory, Multiple Sclerosis Center, Sheba Medical Center, Israel; Sackler School of Medicine, Tel-Aviv University, Israel.

Spontaneous neural repair from endogenous neural stem cells' (NSCs) niches occurs in response to central nervous system (CNS) injuries to only a limited extent. Uncovering the mechanisms that control neural repair and can be further manipulated to promote NSCs toward oligodendrocyte progenitors cells (OPCs) and myelinating oligodendrocytes is a major objective. In the current study, we describe high-throughput transcriptional changes in adult mouse subventricular zone (SVZ)-NSCs during differentiation in vitro. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2017.09.018DOI Listing
November 2017
4 Reads

Laceration Management.

J Emerg Med 2017 Sep 25;53(3):369-382. Epub 2017 Aug 25.

East Orange General Hospital, East Orange, New Jersey.

Background: Traumatic lacerations to the skin represent a fairly common reason for seeking emergency department care. Although the incidence of lacerations has decreased over the past decades, traumatic cutaneous lacerations remain a common reason for patients to seek emergency department care.

Objective: Innovations in laceration management have the potential to improve patient experience with this common presentation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07364679173047
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http://dx.doi.org/10.1016/j.jemermed.2017.05.026DOI Listing
September 2017
6 Reads

Glucocorticoid-Induced Leucine Zipper Protects the Retina From Light-Induced Retinal Degeneration by Inducing Bcl-xL in Rats.

Invest Ophthalmol Vis Sci 2017 07;58(9):3656-3668

Department of Ophthalmology, Eye and Ear Nose Throat Hospital of Fudan University, Shanghai, China 2Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, China.

Purpose: The aim of the present study was to investigate the neuroprotective effects of glucocorticoid-induced leucine zipper (GILZ) in a light-induced retinal degeneration model and to explore the underlying mechanisms.

Methods: Intravitreal injection of recombinant GILZ-overexpressing lentivirus (OE-GILZ-rLV) and short hairpin RNA targeting GILZ recombinant lentivirus (shRNA-GILZ-rLV) was performed to up- and downregulate retinal GILZ, respectively. Three days after stable transduction, rats were exposed to continuous bright light (5000 lux) for 2 days. Read More

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http://dx.doi.org/10.1167/iovs.17-22116DOI Listing
July 2017
12 Reads

Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons.

Neuron 2017 Jun;94(6):1142-1154.e6

Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Solomon H. Snyder Department of Neuroscience, Department of Molecular Biology and Genetics, Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

Dual leucine zipper kinase (DLK) has been implicated in cell death signaling secondary to axonal damage in retinal ganglion cells (RGCs) and other neurons. To better understand the pathway through which DLK acts, we developed enhanced functional genomic screens in primary RGCs, including use of arrayed, whole-genome, small interfering RNA libraries. Explaining why DLK inhibition is only partially protective, we identify leucine zipper kinase (LZK) as cooperating with DLK to activate downstream signaling and cell death in RGCs, including in a mouse model of optic nerve injury, and show that the same pathway is active in human stem cell-derived RGCs. Read More

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http://dx.doi.org/10.1016/j.neuron.2017.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553555PMC
June 2017
35 Reads

[Preparation and application of cooling bag for heat stroke in wild field].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2017 May;29(5):479-480

Department of Critical Care Medicine, the 401st Hospital of PLA, Qingdao 266071, Shandong, China (Li HL, Wang HP); Division of Medical Affairs, the 401st Hospital of PLA, Qingdao 266071, Shandong, China (Lu Q, Li LJ). Corresponding author: Li Lujia, Email:

Objective: Cooling bag for heat stroke in wild field was invented in order to fulfill rapid cooling for heat stroke in field environment. The cooling bag is composed of the hood, the body cover (which is made up of the anterior portion, the linking, and the posterior portion), the fixed straps, the handles. The length is 200 cm, the regulative width is 60-70 cm, the folding volume is 26 cm × 20 cm × 9 cm, and the weight is 1. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2017.05.019DOI Listing
May 2017
9 Reads

Acute Foreskin Strangulation Injury due to Bathing Suit Mesh Entrapment.

Urol Case Rep 2017 Jul 26;13:85-86. Epub 2017 Apr 26.

University of Central Florida College of Medicine, 6850 Lake Nona Boulevard, Orlando, FL 32827, USA.

Genital injury can occur at any age of life but is most common in the pediatric population. Hair-tourniquets and circumcision procedures are the most common causes of penile injury in children. Foreskin trauma, aside from zipper related injuries, is sparsely reported. Read More

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http://dx.doi.org/10.1016/j.eucr.2016.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409500PMC
July 2017
5 Reads

DLK silencing attenuated neuron apoptosis through JIP3/MA2K7/JNK pathway in early brain injury after SAH in rats.

Neurobiol Dis 2017 Jul 8;103:133-143. Epub 2017 Apr 8.

Departments of Anesthesiology and Physiology, Loma Linda University School of Medicine, Loma Linda, CA, USA. Electronic address:

Objective: Dual leucine zipper kinase (DLK/MA3K12) has been reported involved in apoptosis and neuronal degeneration during neural development and traumatic brain injury. This study was designed to investigate the role of DLK with its adaptor protein JNK interacting protein-3 (JIP3), and its downstream MA2K7/JNK signaling pathway in early brain injury (EBI) after subarachnoid hemorrhage (SAH) in a rat model.

Design: Controlled in vivo laboratory study. Read More

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http://dx.doi.org/10.1016/j.nbd.2017.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493044PMC
July 2017
11 Reads

Ultrasound-guided dorsal penile nerve block performed in a case of zipper entrapment injury.

J Clin Ultrasound 2017 Nov 10;45(9):589-591. Epub 2017 Feb 10.

Mount Sinai St. Luke's Mount Sinai West Hospitals, Department of Emergency Medicine, 1000 10th Avenue, New York, NY.

Injury to the penis resulting from zipper entrapment is a painful condition that presents a unique anesthetic challenge to the emergency physician and may even require procedural sedation for removal. In this case report, we describe successful removal of zipper entrapment from the penis of a 34-year-old patient after the application of an ultrasound-guided dorsal penile nerve block. We discuss the anatomy, sonographic features, and steps required for the nerve block procedure. Read More

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http://doi.wiley.com/10.1002/jcu.22459
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http://dx.doi.org/10.1002/jcu.22459DOI Listing
November 2017
5 Reads

Genetic ablation of Bach1 gene enhances recovery from hyperoxic lung injury in newborn mice via transient upregulation of inflammatory genes.

Pediatr Res 2017 Jun 18;81(6):926-931. Epub 2017 Jan 18.

Department of Pediatrics, Saitama Medical Center, Saitama Medical University, Saitama, Japan.

Background: BTB and CNC homology 1 (Bach1) is a transcriptional repressor of heme oxygenase (HO)-1. The effects of Bach1 disruption on hyperoxic lung injury in newborn mice have not been determined. We aimed to investigate the role of Bach1 in the newborns exposed to hyperoxia. Read More

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http://dx.doi.org/10.1038/pr.2017.17DOI Listing
June 2017
3 Reads

Occult Perforating Globe Injury Caused by Intraocular Foreign Body.

Ophthalmic Surg Lasers Imaging Retina 2016 12;47(12):1162-1163

Intraocular foreign bodies (IOFBs) may be associated with occult exit wounds. The authors present a case of a man who sustained a zipper-tooth IOFB through the cornea from a car tire explosion. CT showed an IOFB within the vitreous cavity, but the IOFB was not identified during vitrectomy. Read More

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http://dx.doi.org/10.3928/23258160-20161130-14DOI Listing
December 2016
6 Reads

Comparative analysis of five methods of emergency zipper release by experienced versus novice clinicians.

Am J Emerg Med 2017 05 2;35(5):783-784. Epub 2016 Nov 2.

Michigan State University, College of Human Medicine, Department of Emergency Medicine, United States; Spectrum Health, Department of Emergency Medicine, Grand Rapids, MI, United States.

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http://dx.doi.org/10.1016/j.ajem.2016.11.005DOI Listing
May 2017
6 Reads

Systematic Review and Meta-Analysis of Surgical Zipper Technique versus Intracutaneous Sutures for the Closing of Surgical Incision.

PLoS One 2016 9;11(9):e0162471. Epub 2016 Sep 9.

Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, P.R. China.

Background: It is controversial whether surgical zipper technique (SZT), a non-invasive method of surgical wound closure, achieves a better outcome of incision healing than intracutaneous sutures (IS) in the surgery. This meta-analysis was performed to systematically analyze whether surgical zipper is superior to suture material for the incision closure.

Methods: Databases and reference lists were searched for randomized controlled trials (RCTs) comparing SZT with IS for the incision closure. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0162471PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017696PMC
August 2017
10 Reads

Tozasertib attenuates neuronal apoptosis via DLK/JIP3/MA2K7/JNK pathway in early brain injury after SAH in rats.

Neuropharmacology 2016 09 13;108:316-23. Epub 2016 Apr 13.

Departments of Anesthesiology and Physiology, Loma Linda University School of Medicine, Loma Linda, CA, USA. Electronic address:

Background And Purpose: Since tozasertib is neuroprotective for injured optic nerve, this study is intended to test whether tozasertib reduces early brain injury after subarachnoid hemorrhage (SAH) in a rat model.

Methods: Two hundred sixteen (216) male Sprague-Dawley rats were randomly subjected to endovascular perforation model of SAH and sham group. SAH grade, neurological score, and brain water content were measured at 24 and 72 h after SAH. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2016.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912887PMC
September 2016
13 Reads

Nrf2 plays a pivotal role in protection against burn trauma-induced intestinal injury and death.

Oncotarget 2016 Apr;7(15):19272-83

Department of Cardiothoracic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a basic leucine zipper transcription factor that principally defends against oxidative stress and also plays a unique role in severe sepsis. However, its contribution to intestinal injury and death after burn trauma is unclear.In this study, wild-type (Nrf2+/+) and Nrf2-deficient (Nrf2-/-) mice were subjected to 15% or 30% total body surface area burn or sham injury. Read More

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http://dx.doi.org/10.18632/oncotarget.8189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991382PMC
April 2016
11 Reads

Increase of transcription factor EB (TFEB) and lysosomes in rat DRG neurons and their transportation to the central nerve terminal in dorsal horn after nerve injury.

Neuroscience 2016 Jan 19;313:10-22. Epub 2015 Nov 19.

Department of Functional Anatomy & Neuroscience, Nagoya University, Graduate School of Medicine, 65 Tsurumaicho, Showa-ku, Nagoya 466-8550, Japan; Core Research for Evolutional Science and Technology (CREST) of the Japan Science and Technology Agency (JST), Saitama, Japan. Electronic address:

In the spinal dorsal horn (DH), nerve injury activates microglia and induces neuropathic pain. Several studies clarified an involvement of adenosine triphosphate (ATP) in the microglial activation. However, the origin of ATP together with the release mechanism is unclear. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2015.11.028DOI Listing
January 2016
11 Reads

Gold nanoparticles induce heme oxygenase-1 expression through Nrf2 activation and Bach1 export in human vascular endothelial cells.

Int J Nanomedicine 2015 21;10:5925-39. Epub 2015 Sep 21.

School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan.

It has been reported that increased levels and activity of the heme oxygenase-1 (HO-1) protein ameliorate tissue injuries. In the present study, we investigated the effects and mechanisms of action of gold nanoparticles (AuNPs) on HO-1 protein expression in human vascular endothelial cells (ECs). The AuNPs induced HO-1 protein and mRNA expression in a concentration- and time-dependent manner. Read More

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http://dx.doi.org/10.2147/IJN.S88514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590552PMC
August 2016
11 Reads

The molecular fingerprint of lung inflammation after blunt chest trauma.

Eur J Med Res 2015 Aug 25;20:70. Epub 2015 Aug 25.

Department of Traumatology, Hand-, Plastic-, and Reconstructive Surgery, Center of Surgery, University of Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany.

Background: After severe blunt chest trauma, the development of an acute lung injury (ALI) is often associated with severe or even lethal complications. Especially in multiple injured patients after blunt chest trauma ALI/ARDS [acute respiratory distress syndrome (ARDS)] is frequent. However, in the initial posttraumatic phase, inflammatory clinical signs are often not apparent and underlying changes in gene-expression profile are unknown. Read More

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http://www.eurjmedres.com/content/20/1/70
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http://dx.doi.org/10.1186/s40001-015-0164-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548898PMC
August 2015
20 Reads

Genetic Deletion of the Transcriptional Repressor NFIL3 Enhances Axon Growth In Vitro but Not Axonal Repair In Vivo.

PLoS One 2015 20;10(5):e0127163. Epub 2015 May 20.

Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, Amsterdam, The Netherlands.

Axonal regeneration after injury requires the coordinated expression of genes in injured neurons. We previously showed that either reducing expression or blocking function of the transcriptional repressor NFIL3 activates transcription of regeneration-associated genes Arg1 and Gap43 and strongly promotes axon outgrowth in vitro. Here we tested whether genetic deletion or dominant-negative inhibition of NFIL3 could promote axon regeneration and functional recovery after peripheral nerve lesion in vivo. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127163PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438979PMC
April 2016
10 Reads

An uncommon oesophageal foreign body in a neonate.

BMJ Case Rep 2015 Jan 30;2015. Epub 2015 Jan 30.

Department of ENT, Pandit Bhagwat Dayal PGIMS, Rohtak Haryana, India.

We report a case of a 2-month-old male child who presented with sudden onset of vomiting and refusal to breast feed. Chest and abdomen examination were normal. A foreign body (zipper) was visualised in the cervical oesophagus on X-ray of the neck. Read More

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http://casereports.bmj.com/content/2015/bcr-2014-208719.full
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http://casereports.bmj.com/cgi/doi/10.1136/bcr-2014-208719
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http://dx.doi.org/10.1136/bcr-2014-208719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322268PMC
January 2015
4 Reads

Endoplasmic reticulum proteins quality control and the unfolded protein response: the regulative mechanism of organisms against stress injuries.

Biofactors 2014 Nov-Dec;40(6):569-85. Epub 2014 Dec 20.

Division of National Research Center for Apple Engineering and Technology, Shandong Agricultural University, Tai'an, Shandong, China; Division of State Key Laboratory of Crop Biology, Shandong Agricultural University, Tai'an, Shandong, China; College of Horticulture Science and Engineering, Shandong Agricultural University, Tai'an, Shandong, China.

The endoplasmic reticulum is the cellular compartment in which secretory proteins are synthesized and folded. Perturbations of endoplasmic reticulum homeostasis lead to the accumulation of unfolded proteins. The activation of the unfolded protein response during endoplasmic reticulum stress transmits information about the status of protein folding to the cytosol and nucleus. Read More

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http://dx.doi.org/10.1002/biof.1194DOI Listing
September 2015
4 Reads

Chemopreventive apigenin controls UVB-induced cutaneous proliferation and angiogenesis through HuR and thrombospondin-1.

Oncotarget 2014 Nov;5(22):11413-27

Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Plant flavonoid apigenin prevents and inhibits UVB-induced carcinogenesis in the skin and has strong anti-proliferative and anti-angiogenic properties. Here we identify mechanisms, by which apigenin controls these oncogenic events. We show that apigenin acts, at least in part, via endogenous angiogenesis inhibitor, thrombospondin-1 (TSP1). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294383PMC
http://dx.doi.org/10.18632/oncotarget.2551DOI Listing
November 2014
14 Reads

Sensing nerve injury at the axonal ER: activated Luman/CREB3 serves as a novel axonally synthesized retrograde regeneration signal.

Proc Natl Acad Sci U S A 2014 Nov 27;111(45):16142-7. Epub 2014 Oct 27.

Departments of Anatomy and Cell Biology and Cameco Multiple Sclerosis Neuroscience Research Center, University of Saskatchewan, Saskatoon, SK, Canada S7N 5E5

Luman/cAMP response element binding protein 3 is an endoplasmic reticulum (ER) transmembrane basic leucine zipper transcription factor whose mRNA and protein localize to adult sensory axons, the latter with axonal ER components along the axon length. Here we show that axon-derived Luman plays an important role in relaying information about axonal injury to the neuronal cell body. Axotomy induces axonal Luman synthesis and also release from the axonal ER of Luman's transcriptionally active amino terminus, which is transported to the cell body in an importin-mediated manner. Read More

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http://dx.doi.org/10.1073/pnas.1407462111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234591PMC
November 2014
4 Reads

[Feasibility and limits of clinical neurophysiology with regard to the objective evaluation of neurological consequences following accidents].

Authors:
Stephan G Zipper

Versicherungsmedizin 2014 Sep;66(3):132-6

It is not unusual for a neurological expert to have problems defining the precise anatomical location and the required objective proof of damage, especially if the medical history and the neurological report released by the clinic prove inadequate in terms of providing a reliable assessment. This may well result from somatoform disorders, dissociation, aggravation and simulation, as well as dissimulation and complex organic diagnostic findings. A range of standardised neurophysiologic procedures is available for the objective measuring of motor, vegetative and sensory systems; a brief summary of the most frequent occurrences is given here, along with their significance for appraising damage resulting from an accident. Read More

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September 2014
2 Reads

Curcumin ameliorates cognitive deficits heavy ion irradiation-induced learning and memory deficits through enhancing of Nrf2 antioxidant signaling pathways.

Pharmacol Biochem Behav 2014 Nov 23;126:181-6. Epub 2014 Aug 23.

Institute of Modern Physics, Chinese Academy of Sciences, 509 Nanchang Road, Lanzhou 730000, China; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Nanchang Road, Lanzhou 730000, China; Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Nanchang Road, Lanzhou 730000, China. Electronic address:

Oxidative stress is one of the major mechanisms implicated in carbon ion irradiation. Curcumin is a natural phenolic compound with impressive antioxidant properties. What's more, curcumin is recently proved to exert its effects partly radioprotection. Read More

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http://dx.doi.org/10.1016/j.pbb.2014.08.005DOI Listing
November 2014
36 Reads

Glucocorticoid-induced leucine zipper (GILZ) controls inflammation and tissue damage after spinal cord injury.

CNS Neurosci Ther 2014 Nov 21;20(11):973-81. Epub 2014 Aug 21.

IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Messina, Italy.

Aims: Spinal cord injury (SCI) occurs following damage to the spinal column. Following trauma, tissue damage is further exacerbated by a secondary damage due to a SCI-activated inflammatory process. Control of leukocytes activity is essential to therapeutic inhibition of the spinal cord damage to ameliorate the patient's conditions. Read More

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http://dx.doi.org/10.1111/cns.12315DOI Listing
November 2014
8 Reads

ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates.

J Neurosci 2014 Aug;34(32):10729-42

Department of Neurology, School of Medicine and Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children Northern California, Sacramento, California 95817.

Motoneuron death after transection of the axons (axotomy) in neonates is believed to share the same mechanistic bases as naturally occurring programmed cell death during development. The c-Jun N-terminal kinase pathway is activated in both forms of motoneuron death, but it remains unknown to what extent these two forms of motoneuron death depend on this pathway and which upstream kinases are involved. We found that numbers of facial motoneurons are doubled in neonatal mice deficient in either ZPK/DLK (zipper protein kinase, also known as dual leucine zipper kinase), a mitogen-activated protein kinase kinase kinase, or in MKK4/MAP2K4, a mitogen-activated protein kinase kinase directly downstream of ZPK/DLK, and that the facial motoneurons in those mutant mice are completely resistant to axotomy-induced death. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.0539-14.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200111PMC
August 2014
6 Reads

Analysis of mtDNA, miR-155 and BACH1 expression in hearts from donors with and without Down syndrome.

Mitochondrial DNA A DNA Mapp Seq Anal 2016 18;27(2):896-903. Epub 2014 Jun 18.

a Department of Pharmaceutical Sciences, University at Buffalo , The State University of New York , Buffalo , NY , USA.

Cancer patients with Down syndrome (DS) are at increased risk for anthracycline-related cardiotoxicity. Mitochondrial DNA (mtDNA) alterations in hearts with-DS may contribute to anthracycline-related cardiotoxicity. Cardiac mtDNA and the mtDNA(4977) deletion were quantitated in samples with- (n = 11) and without-DS (n = 31). Read More

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http://dx.doi.org/10.3109/19401736.2014.926477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315749PMC
September 2016
30 Reads

OASIS regulates chondroitin 6-O-sulfotransferase 1 gene transcription in the injured adult mouse cerebral cortex.

J Neurochem 2014 Sep 7;130(5):612-25. Epub 2014 May 7.

Department of Anatomy and Neuroscience, Faculty of Medicine, Nara Medical University, Kashihara, Japan.

Old astrocyte specifically induced substance (OASIS), a basic leucine zipper transcription factor of the cAMP response element binding/Activating transcription factor family, is induced in reactive astrocytes in vivo and has important roles in quality control of protein synthesis at the endoplasmic reticulum. Reactive astrocytes produce a non-permissive environment for regenerating axons by up-regulating chondroitin sulfate proteoglycans (CSPGs). In this study, we focus on the potential role of OASIS in CSPG production in the adult mouse cerebral cortex. Read More

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http://dx.doi.org/10.1111/jnc.12736DOI Listing
September 2014
3 Reads

Infant deaths and injuries associated with wearable blankets, swaddle wraps, and swaddling.

J Pediatr 2014 May 7;164(5):1152-6. Epub 2014 Feb 7.

Goldberg Center for Community Pediatric Health, Children's National Medical Center, Washington, DC; Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC. Electronic address:

Objective: To assess risks involved in using wearable blankets, swaddle wraps, and swaddling.

Study Design: This was a retrospective review of incidents reported to the Consumer Product Safety Commission between 2004 and 2012.

Results: A total of 36 incidents involving wearable blankets and swaddle wraps were reviewed, including 10 deaths, 2 injuries, and 12 incidents without injury. Read More

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http://dx.doi.org/10.1016/j.jpeds.2013.12.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992172PMC
May 2014
19 Reads

Wound-induced expression of DEFECTIVE IN ANTHER DEHISCENCE1 and DAD1-like lipase genes is mediated by both CORONATINE INSENSITIVE1-dependent and independent pathways in Arabidopsis thaliana.

Plant Cell Rep 2014 Jun 16;33(6):849-60. Epub 2014 Jan 16.

Department of Biological Mechanisms and Functions, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, 464-8601, Japan.

Endogenous JA production is not necessary for wound-induced expression of JA-biosynthetic lipase genes such as DAD1 in Arabidopsis. However, the JA-Ile receptor COI1 is often required for their JA-independent induction. Wounding is a serious event in plants that may result from insect feeding and increase the risk of pathogen infection. Read More

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http://dx.doi.org/10.1007/s00299-013-1561-8DOI Listing
June 2014
4 Reads

Severe penile injuries in children and adolescents: reconstruction modalities and outcomes.

Urology 2014 Feb 22;83(2):465-70. Epub 2013 Nov 22.

Detroit Medical Center, Detroit, MI.

Objective: To review our experience with severe penile trauma, mechanism of injury, and their treatment modalities in 16 children younger than 18 years. Management of penile trauma poses diverse challenges to the reconstructive urologist, as injuries vary from abrasions to total emasculation.

Methods: Analysis of 16 patients with severe penile injuries referred to us between 2002 and 2011 was undertaken. Read More

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http://dx.doi.org/10.1016/j.urology.2013.10.015DOI Listing
February 2014
8 Reads

A new nonsurgical technique for managing zipper injuries.

Eur J Emerg Med 2014 Aug;21(4):308-9

St Mary's Hospital Imperial College Healthcare NHS Trust, London, UK.

Zipper injuries are highly distressing to patients and often difficult to manage. Several management techniques are described in the literature. Many are complex and laborious, requiring sophisticated instruments in skilled hands, or even rely on a formal operation. Read More

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http://dx.doi.org/10.1097/MEJ.0000000000000073DOI Listing
August 2014
4 Reads

Increased lysosomal biogenesis in activated microglia and exacerbated neuronal damage after traumatic brain injury in progranulin-deficient mice.

Neuroscience 2013 Oct 2;250:8-19. Epub 2013 Jul 2.

Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.

Progranulin (PGRN) is known to play a role in the pathogenesis of neurodegenerative diseases. Recently, it has been demonstrated that patients with the homozygous mutation in the GRN gene present with neuronal ceroid lipofuscinosis, and there is growing evidence that PGRN is related to lysosomal function. In the present study, we investigated the possible role of PGRN in the lysosomes of activated microglia in the cerebral cortex after traumatic brain injury (TBI). Read More

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http://dx.doi.org/10.1016/j.neuroscience.2013.06.049DOI Listing
October 2013
10 Reads

Dendritic cells in liver injury and fibrosis: shortcomings and promises.

J Hepatol 2013 Nov 29;59(5):1124-6. Epub 2013 May 29.

Department of Medicine II, Saarland University Medical Center, Homburg, Germany. Electronic address:

The phenotype and function of liver dendritic cells (LDCs) are poorly understood. This Snapshot summarizes our current knowledge on LDCs in the healthy and injured liver, and their role in fibrosis progression and reversal. It also draws attention to various pitfalls in the current experimental design and conclusions based on available data. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688278130036
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http://dx.doi.org/10.1016/j.jhep.2013.05.033DOI Listing
November 2013
3 Reads

A repressor protein, Mnt, is a novel negative regulator of vascular smooth muscle cell hypertrophy by angiotensin II and neointimal hyperplasia by arterial injury.

Atherosclerosis 2013 May 13;228(1):90-3. Epub 2013 Mar 13.

Cardiovascular Research Center, Temple University School of Medicine, 3500 N Broad Street, Philadelphia, PA 19140, USA.

Objective: The Max-interacting protein Mnt is a transcriptional repressor that can antagonize the transcriptional and proliferation-related activities of Myc. Here, we tested the hypothesis that Mnt is a negative regulator of pathological vascular remodeling.

Methods: Adenovirus encoding Mnt or control GFP was infected to cultured rat vascular smooth muscle cells (VSMC) and carotid arteries after a balloon angioplasty. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2013.02.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703465PMC
May 2013
2 Reads
1 Citation
3.994 Impact Factor

Cobalt protoporphyrin accelerates TFEB activation and lysosome reformation during LPS-induced septic insults in the rat heart.

PLoS One 2013 15;8(2):e56526. Epub 2013 Feb 15.

Section of Forensic Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo Japan.

Lipopolysaccharide (LPS)-induced myocardial dysfunction is caused, at least in part, by mitochondrial dysfunction. Mitochondrial dysfunction and the oxidative damage associated with it are scavenged through various cellular defense systems such as autophagy to prevent harmful effects. Our recent study has demonstrated that cobalt protoporphyrin IX (CoPPIX), a potent inducer of heme oxygenase-1 (HO-1), ameliorates septic liver injuries by enhancing mitochondrial autophagy in rats. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0056526PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574118PMC
August 2013
3 Reads

DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury.

Proc Natl Acad Sci U S A 2013 Mar 19;110(10):4039-44. Epub 2013 Feb 19.

Neurodegeneration Laboratories, Department of Neuroscience, Gentech, Inc., South San Francisco, CA 94080, USA.

The cell intrinsic factors that determine whether a neuron regenerates or undergoes apoptosis in response to axonal injury are not well defined. Here we show that the mixed-lineage dual leucine zipper kinase (DLK) is an essential upstream mediator of both of these divergent outcomes in the same cell type. Optic nerve crush injury leads to rapid elevation of DLK protein, first in the axons of retinal ganglion cells (RGCs) and then in their cell bodies. Read More

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http://www.pnas.org/cgi/doi/10.1073/pnas.1211074110
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http://dx.doi.org/10.1073/pnas.1211074110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593899PMC
March 2013
8 Reads

Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death.

Proc Natl Acad Sci U S A 2013 Mar 19;110(10):4045-50. Epub 2013 Feb 19.

Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Glaucoma, a major cause of blindness worldwide, is a neurodegenerative optic neuropathy in which vision loss is caused by loss of retinal ganglion cells (RGCs). To better define the pathways mediating RGC death and identify targets for the development of neuroprotective drugs, we developed a high-throughput RNA interference screen with primary RGCs and used it to screen the full mouse kinome. The screen identified dual leucine zipper kinase (DLK) as a key neuroprotective target in RGCs. Read More

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http://dx.doi.org/10.1073/pnas.1211284110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593842PMC
March 2013
20 Reads
69 Citations
9.810 Impact Factor

The Highwire ubiquitin ligase promotes axonal degeneration by tuning levels of Nmnat protein.

PLoS Biol 2012 4;10(12):e1001440. Epub 2012 Dec 4.

Department of Molecular Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America.

Axonal degeneration is a hallmark of many neuropathies, neurodegenerative diseases, and injuries. Here, using a Drosophila injury model, we have identified a highly conserved E3 ubiquitin ligase, Highwire (Hiw), as an important regulator of axonal and synaptic degeneration. Mutations in hiw strongly inhibit Wallerian degeneration in multiple neuron types and developmental stages. Read More

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http://dx.doi.org/10.1371/journal.pbio.1001440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514318PMC
May 2013
15 Reads

A novel, nonoperative treatment for delayed penile zipper injury.

Am J Emerg Med 2013 Feb 15;31(2):419-20. Epub 2012 Nov 15.

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http://dx.doi.org/10.1016/j.ajem.2012.08.034DOI Listing
February 2013
3 Reads

Heme oxygenase-1 modulates degeneration of the intervertebral disc after puncture in Bach 1 deficient mice.

Eur Spine J 2012 Sep 26;21(9):1748-57. Epub 2012 Jul 26.

Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi, Hiroshima, 734-8551, Japan,

Purpose: Intervertebral disc degeneration is considered to be a major feature of low back pain. Furthermore, oxidative stress has been shown to be an important factor in degenerative diseases such as osteoarthritis and is considered a cause of intervertebral disc degeneration. The purpose of this study was to clarify the correlation between oxidative stress and intervertebral disc degeneration using Broad complex-Tramtrack-Bric-a-brac and cap'n'collar homology 1 deficient (Bach 1-/-) mice which highly express heme oxygenase-1 (HO-1). Read More

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http://dx.doi.org/10.1007/s00586-012-2442-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459108PMC
September 2012
6 Reads

Dual leucine zipper kinase is required for retrograde injury signaling and axonal regeneration.

Neuron 2012 Jun;74(6):1015-22

Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Here we demonstrate that the dual leucine zipper kinase (DLK) promotes robust regeneration of peripheral axons after nerve injury in mice. Peripheral axon regeneration is accelerated by prior injury; however, DLK KO neurons do not respond to a preconditioning lesion with enhanced regeneration in vivo or in vitro. Assays for activation of transcription factors in injury-induced proregenerative pathways reveal that loss of DLK abolishes upregulation of p-STAT3 and p-cJun in the cell body after axonal injury. Read More

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http://dx.doi.org/10.1016/j.neuron.2012.04.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383631PMC
June 2012
10 Reads

DLK: the "preconditioning" signal for axon regeneration?

Neuron 2012 Jun;74(6):961-3

Biology Department, University of Utah, Salt Lake City, UT 84112, USA.

In this issue of Neuron, Shin et al. (2012) show that the dual leucine zipper kinase (DLK) is responsible for the retrograde injury signal in spinal sensory and motor neurons. DLK is required for the accelerated regeneration seen after axotomy and for the improved regeneration seen after a conditioning injury. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08966273120051
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http://dx.doi.org/10.1016/j.neuron.2012.06.005DOI Listing
June 2012
6 Reads

Glucocorticoid-induced leucine zipper (GILZ) over-expression in T lymphocytes inhibits inflammation and tissue damage in spinal cord injury.

Neurotherapeutics 2012 Jan;9(1):210-25

Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Torre Biologica, Policlinico Universitario, Messina, Italy.

Spinal cord injury (SCI) is a traumatic event that causes a secondary and extended inflammation characterized by infiltration of immune cells, including T lymphocytes, release of pro-inflammatory mediators in the lesion site, and tissue degeneration. Current therapeutic approaches for SCI are limited to glucocorticoids (GC) due to their potent anti-inflammatory activity. GC efficacy resides, in part, in the capability to inhibit NF-κB, T lymphocyte activation, and the consequent cytokine production. Read More

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http://dx.doi.org/10.1007/s13311-011-0084-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271152PMC
January 2012
6 Reads

Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after injury.

Development 2011 Nov;138(22):4843-52

Centre for Skin Sciences, School of Life Sciences, University of Bradford, UK.

The Lhx2 transcription factor plays essential roles in morphogenesis and patterning of ectodermal derivatives as well as in controlling stem cell activity. Here, we show that during murine skin morphogenesis, Lhx2 is expressed in the hair follicle (HF) buds, whereas in postnatal telogen HFs Lhx2(+) cells reside in the stem cell-enriched epithelial compartments (bulge, secondary hair germ) and co-express selected stem cell markers (Sox9, Tcf4 and Lgr5). Remarkably, Lhx2(+) cells represent the vast majority of cells in the bulge and secondary hair germ that proliferate in response to skin injury. Read More

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http://dx.doi.org/10.1242/dev.070284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067271PMC
November 2011
37 Reads