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Rev Esp Enferm Dig 2022 Jun 24. Epub 2022 Jun 24.

Gastroenterología, Fundación Santa Fe de Bogotá. Hospital Universitario.

Clinical case of a patient who underwent small bowel examination with endoscopic capsule which was never recovered and two years later presented with dysphagia and was found with the capsule inside a Zenker´s diverticulum. Read More

J Visc Surg 2022 Jun 11. Epub 2022 Jun 11.

Service de Chirurgie Générale et Digestive, Hôpitaux Universitaires de Strasbourg, Hôpital de Hautepierre, avenue Molière, 67098 Strasbourg cedex, France. Electronic address:

Khirurgiia (Mosk) 2022 (4):105-109

National Medical Research Center of Oncology, Rostov-on-Don, Russia.

Squamous cell carcinoma in Zenker's diverticulum was first described in 1933. No large studies have yet been conducted due to rarity of this disease. There are a lot of unresolved issues regarding diagnosis and treatment of this pathology. Read More

J Clin Gastroenterol 2022 07 11;56(6):552. Epub 2022 Apr 11.

Department of Gastroenterology Hepatopancreatology and Digestive Oncology, Erasme University Hospital Brussels, Belgium.

Orv Hetil 2022 Apr 24;163(17):677-687. Epub 2022 Apr 24.

1 Magyar Honvédség Egészségügyi Központ, Honvédkórház, Gasztroenterológiai Osztály Budapest, Róbert Károly krt. 44., 1134 Magyarország.

Összefoglaló. Bevezetés: A musculus cricopharyngeus flexibilis endoszkópos myotomiája a tüneteket okozó Zenker-diverticulum hatékony, biztonságos kezelési módszere. Célkitűzés és módszer: Retrospektíven elemeztük a hagyományos flexibilis endoszkópos myotomia eljárással szerzett tapasztalatainkat. Read More

Ther Umsch 2022 Apr;79(3-4):141-144

Klinik für Viszeral- und Transplantationschirurgie, Universitätsspital Zürich.

Update Esophageal Diverticula Esophageal diverticula are rare diseases typically associated pathophysiologically with esophageal dysmotility. The most common location (about 80%) is pharyngo-oesophageal. The therapy must be adapted to the location, the size, the symptoms and also the individual perioperative risk of the patient. Read More

World J Gastrointest Endosc 2022 Mar;14(3):183-190

Department of Surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.

Background: Bleeding from Zenker's diverticulum is extremely rare. At present, there are no guidelines for the management of bleeding Zenker's diverticulum because of its rarity. Per-oral endoscopic myotomy (Z-POEM) is a precision myotomy technique and minimally invasive procedure for the treatment of Zenker's diverticulum. Read More

Cureus 2022 Feb 18;14(2):e22369. Epub 2022 Feb 18.

Otolaryngology, Mayo Clinic, Jacksonville, USA.

Objective: Zenker's diverticulum (ZD) is usually associated with dysphagia and other symptoms due to the interrelated functions of several systems. Surgical management of ZD is effective for all sizes of diverticula, but not all patients decide to undergo surgery. The purpose of this study was to determine the relationship between clinical presentation and patients' decision to undergo surgical repair. Read More

Intern Med 2022 1;61(7):943-949. Epub 2022 Apr 1.

Division of Gastroenterology, Niigata University Faculty of Medical Graduate School of Medical and Dental Science, Japan.

Objective Esophageal diverticulum is rare, and the concomitance of esophageal motility disorders (EMDs) and the efficacy of novel endoscopic treatment have not been investigated in Japan. Methods An examination including high-resolution manometry (HRM) was performed for patients with both EMDs and epiphrenic diverticulum. EMD-related epiphrenic diverticulum and Zenker's diverticulum were treated using salvage peroral endoscopic myotomy (s-POEM) and endoscopic diverticulotomy, respectively. Read More

Dig Dis Sci 2022 05 2;67(5):1500-1520. Epub 2022 Apr 2.

Division of Gastroenterology, Hepatology and Nutrition, NYU-Winthrop Hospital, 222 Station Plaza N Suite 429, Mineola, NY, 11501, USA.

Our tripartite narrative review discusses Peroral Endoscopic Myotomy (POEM), gastric POEM (GPOEM) and POEM for Zenker's diverticula (ZPOEM). POEM is the prototypical procedure that launched the novel "3rd space endoscopy" field of advanced endoscopy. It revolutionized achalasia therapy by offering a much less invasive version of the prior gold standard, the laparoscopic Heller myotomy (HM). Read More

Surg Clin North Am 2022 Apr 4;102(2):199-207. Epub 2022 Mar 4.

Division of Laryngology, Department of Otolaryngology, University of Florida, 1345 Center Drive, PO Box 100264, Gainesville, FL 32610, USA. Electronic address:

Esophageal dysphagia presents acutely, most frequently as a food impaction, or in a progressive fashion. Anatomic changes are frequently responsible. Although the history may be suggestive, diagnosis is made from imaging or endoscopic studies. Read More

Pol Przegl Chir 2021 Sep;94(1):41-47

Department of Thoracic and Surgical Oncology, Jagiellonian University Collegium Medicum, John Paul II Hospital, Cracow, Poland.

Aim Of The Study: The aim of our study is to present the results of surgical treatment of patients with cervical diverticula of the oesophagus in a period of 20 years.

Material And Methods: A retrospective analysis of 65 patients treated between 2000 and 2020. Patients with symptoms such as dysphagia, vomiting, chocking, recurrent respiratory tract inflammation, as well as patients with diverticular recurrence or poor outcome of primary surgery, were qualified for surgical resection of the oesophageal diverticulum with myotomy using an open technique. Read More

Rozhl Chir 2022 ;101(1):4-13

Gastrointestinal motility disorders include several heterogeneous units affecting the esophagus, stomach, small or large intestine and the rectum. These are namely Zenkers diverticulum, esophageal achalasia, gastroesophageal reflux disease, gastroparesis, constipation, Ogilvies syndrome and post-fundoplication dysphagia. Given the progressive development of endoscopic techniques, patients with most of the above mentioned diseases can be offered a solution consisting of a mini-invasive endoscopic procedure which has already become a first-choice treatment for some of the disorders. Read More

VideoGIE 2022 Jan 30;7(1):26-28. Epub 2021 Oct 30.

Division of Gastroenterology & Hepatology, NewYork-Presbyterian Hospital and Weill Cornell Medical Center, New York, New York.

Video 1Peroral endoscopic myotomy for a residual Zenker's diverticulum following endoscopic myotomy. Read More

Surg Endosc 2022 05 12;36(5):2749-2759. Epub 2022 Jan 12.

Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Street Taiping No.25, Region Jiangyang, Luzhou, 646099, Sichuan Province, China.

Background: Zenker's peroral endoscopic myotomy (Z-POEM) has revolutionized the therapeutic strategy for Zenker's diverticulum (ZD) with promising results. We conducted this meta-analysis to estimate the safety and efficacy of Z-POEM for ZD and compare the feasibility and effectiveness of Z-POEM with that of flexible endoscopic septotomy (FES).

Methods: A comprehensive literature search was conducted in PubMed, EMBASE, Web of Science, and Cochrane Library databases to query for studies that assessed the safety and efficacy of Z-POEM for ZD. Read More

J Int Med Res 2021 Dec;49(12):3000605211065930

Department of Radiology, Jiangxi Provincial People's Hospital, Nanchang, China.

Zenker's diverticulum (ZD) is a bag-like pharyngeal pouch that protrudes to the outside of the pharynx. It is thought to be an acquired disease that occurs following the dysfunction of laryngopharynx muscle, and certain body shapes may be predisposed to this condition. We report a 56-year-old female of slim build with ZD. Read More

JAMA Otolaryngol Head Neck Surg 2022 Mar;148(3):235-242

Clinicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Importance: The incidence of Zenker diverticulum has been established; previous estimates have been extrapolated from small institutional cohorts.

Objective: To describe the population-wide incidence of Zenker diverticulum over a 20-year period and characterize management strategies across specialties and treatment settings.

Design, Setting, And Participants: This retrospective national cohort study was conducted from January 1, 1996, through December 31, 2015, and reviewed patient records from the Care Register for Healthcare in Finland, from which patients with Zenker diverticulum were identified. Read More

Eur J Gastroenterol Hepatol 2021 12;33(1S Suppl 1):e78-e83

Gastroenterology Department, Endoscopy Unit, Humanitas Clinical and Research Center -IRCCS.

In the last decade, flexible endoscopic septotomy has been reported as a well-tolerated and effective treatment for Zenker's diverticulum. More recently, novel endoscopic submucosal tunneling techniques, namely Zenker-PerOral Endoscopic Myotomy (Z-POEM) and PerOral Endoscopic Septotomy (POES) have been proposed to obtain complete muscular septum exposure and deeper myotomy. The aim of this study is to provide a systematic review with a meta-analysis of the first experiences of third space approaches for Zenker's diverticulum. Read More

Acta Otorrinolaringol Esp (Engl Ed) 2021 Nov-Dec;72(6):381-386

Servicio de Otorrinolaringología, Hospital Universitario de Cabueñes, Gijón, Spain.

Introduction: Zenker's diverticulum is an uncommon pathology of the upper oesophageal sphincter whose most frequent symptoms are the association of dysphagia and regurgitation. It is more frequent in advanced ages, and its treatment of choice is surgery in symptomatic cases.

Method: A retrospective descriptive study was performed of 27 patients operated in the Otorhinolaryngology service of the Hospital Universitario de Cabueñes between 2007 and 2019 using laser endoscopic surgery. Read More

Gastroenterol Clin North Am 2021 12 6;50(4):935-958. Epub 2021 Oct 6.

Division of Gastroenterology & Hepatology, Johns Hopkins Medicine, 4940 Eastern Avenue, A Building, 5th Floor, A-501, Baltimore, MD 21224, USA. Electronic address:

Therapeutic gastrointestinal endoscopy is rapidly evolving, and this evolution is quite apparent for esophageal diseases. Minimally invasive endoluminal therapy now allows outpatient treatment of many esophageal diseases that were traditionally managed surgically. In this review article, we explore the most exciting new developments. Read More

Cureus 2021 Sep 8;13(9):e17820. Epub 2021 Sep 8.

General Surgery, Baylor University Medical Center, Dallas, USA.

Killian-Jamieson diverticulum (KJD) is a rare presentation of esophageal diverticulum. It is located beneath the cricopharyngeal muscle and arises laterally from the Killian-Jamieson space. The pathogenesis is postulated to be from increased intraluminal pressure. Read More

J Clin Gastroenterol 2022 01;56(1):16-22

Department of Gastroenterology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.

For more than a decade, per-oral endoscopic myotomy (POEM) has been performed for the treatment of achalasia and other dysmotilities of the esophagus. POEM has become an accepted alternative to Heller myotomy, a salvation technique for patients not responding to Heller myotomy and the favorite intervention for diffuse esophageal spasm and jackhammer esophagus. POEM paved the way for endoscopic pyloromyotomy, Zenker's diverticulum myotomy, and submucosal tunneling with endoscopic resection. Read More

Rev Esp Enferm Dig 2022 Feb;114(2):126-127

Aparato Digestivo, Hospital Universitario de La Princesa, España.

We report the case of an 89-year-old female who presented with progressive weight loss, oropharyngeal dysphagia and food regurgitation. Read More

Eur Arch Otorhinolaryngol 2022 Jan 5;279(1):533-536. Epub 2021 Oct 5.

Department of Otolaryngology Head and Neck Surgery, Flinders Medical Centre and Flinders University, Bedford Park, SA, 5042, Australia.

Background: Various endoscopic methods of dividing the cricopharyngeus muscle and the common wall of pharyngeal pouches have been described, most commonly the carbon dioxide laser and stapler. The potassium titanyl phosphate (KTP) laser is an alternate endoscopic method of treatment.

Methods: The KTP laser is used in a similar fashion to the carbon dioxide laser to carefully divide the cricopharyngeus muscle fibres ± the common wall of the pharyngeal pouch, under microscopic visualization. Read More

Endoscopy 2022 04 24;54(4):352-353. Epub 2021 Sep 24.

Digestive Endoscopy Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Surg Endosc 2022 Jun 15;36(6):4129-4135. Epub 2021 Sep 15.

Digestive Disease Institute, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd, 2nd Floor, Weston, FL, 33331, USA.

Background: Symptomatic Zenker's diverticulum management has evolved from an open intervention to an endoscopic management. At our center, both an otolaryngologist and a gastroenterologist are present in the operating room when treating these lesions. An intra-procedural consensus is reached to undergo either rigid endoscopy or flexible endoscopic diverticulotomy with ENT guidance. Read More

Dig Endosc 2022 05 6;34 Suppl 2:31-35. Epub 2021 Sep 6.

Division of Gastroenterology, Department of Internal Medicine, Aichi Medical University School of Medicine, Aichi, Japan.

BMC Gastroenterol 2021 Aug 30;21(1):338. Epub 2021 Aug 30.

Department of Radiology, Mulago National Referral Hospital, Kampala, Uganda.

Background: Zenker's diverticulum (ZD) is an uncommon disorder due to an outpouching of tissue through the Killian triangle that is thought to be caused by dysfunction of the cricopharyngeal muscle.

Case Presentation: An 85-year-old male patient presented with odynophagia and dysphagia of initially solid food followed by fluids that was associated with a significant weight loss over a one-year period. Barium swallow videofluoroscopy demonstrated a posterior outpouching of proximal esophagus that was 2 cm from the epiglottis. Read More

Eur Rev Med Pharmacol Sci 2021 Jul;25(14):4791-4798

Department of Otorhinolaryngology, Head and Neck Surgery, Friedrich Alexander University of Erlangen-Nuremberg, Erlangen, Germany.

Objective: Very few reports investigated techniques of closure of the basal wound area to reduce severe complications like mediastinitis after endoscopic laser diverticulotomy. In this study, we report our experiences after routine use of a collagen-fibrin sealant patch for basal wound covering after laser diverticulotomy in consideration of postoperative complications and recurrence rates.

Patients And Methods: This retrospective study was conducted in a tertiary referral center and university hospital. Read More

Am J Gastroenterol 2021 09;116(9):1853-1858

Endoscopy Unit, Humanitas Clinical and Research Center, RCCS, Milano, Italy.

Introduction: Multiple therapeutic modalities including surgery and rigid and flexible endoscopy have been adopted to manage Zenker's diverticulum (ZD). Minimally invasive flexible endoscopic septotomy (FES) techniques have been increasingly favored over the past 20 years; however, long-term data are still scanty. The aim of this study is to evaluate early and long-term outcomes of FES for naive ZD in a single-center setting. Read More