2,834 results match your criteria Yolk Sac Tumor


A retrospective analysis of the pattern of care and survival in patients with malignant ovarian germ cell tumors.

South Asian J Cancer 2019 Jan-Mar;8(1):35-40

Department of Biostatistics, Amrita Institute of Medical Sciences, Amrita University, Kochi, Kerala, India.

Objective: The objective of this study is to evaluate the pattern of care and survival outcome in patients with malignant ovarian germ cell tumors (MOGCTs).

Materials And Methods: Between January 2004 and August 2017, 50 patients with MOGCT were identified at Amrita Institute of Medical Sciences and 48 included in analyses. Histologic subtypes were as follows: dysgerminoma 11; immature teratoma 16; yolk sac tumor 3; and mixed germ cell tumor 18. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/sajc.sajc_6_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348783PMC
February 2019

Multidisciplinary team for the diagnosis and treatment of 2 cases of primary intestinal yolk sac tumor.

Cancer Biol Med 2018 Nov;15(4):461-467

Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin's Clinical Research Center for Cancer, Tianjin Medical University, Ministry of Education, Tianjin 300060, China.

Extragonadal primary yolk sac tumor of the intestinal tract origin is exceedingly rare. Through a multiple disciplinary team, the diagnosis and treatment of primary intestinal yolk sac tumor were further defined. We report 2 such cases with detailed histologic and immunohistochemical analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.20892/j.issn.2095-3941.2018.0054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372916PMC
November 2018

An Unusual Case of Primary Retroperitoneal Germ Cell Tumour in a Young Man.

Eur J Case Rep Intern Med 2018 26;5(7):000900. Epub 2018 Jul 26.

Internal Medicine Department, Hospital Beatriz Ângelo, Lisbon, Portugal.

Some 2-5% of germ cell tumours are of extragonadal origin, with a retroperitoneal location being very rare. The majority of retroperitoneal germ cell tumours have metastasized from a testicular tumour. These tumours are diagnosed incidentally or symptomatically and nearly all present with high alpha-fetoprotein and lactate dehydrogenase levels. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12890/2018_000900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346782PMC

A case of ovarian endometrioid adenocarcinoma with yolk sac differentiation and Lynch syndrome.

Gynecol Oncol Rep 2019 Feb 11;27:60-64. Epub 2019 Jan 11.

Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, MD Anderson Cancer Center at Cooper, Cooper University Health System, Camden, NJ, USA.

Ovarian endometrioid adenocarcinoma with yolk sac component has been reported in fewer than twenty cases in the literature. A majority of the diagnoses are described in postmenopausal women without specific reference to germline genetic testing. We describe, to our knowledge, the first case in the English literature of a premenopausal woman that presented with an ovarian endometrioid adenocarcinoma with focal yolk sac component and was subsequently found to have a germline mutation confirming a diagnosis of Lynch syndrome. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S23525789193000
Publisher Site
http://dx.doi.org/10.1016/j.gore.2019.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348978PMC
February 2019
2 Reads

Tumor-infiltrating T cells and PD-L1 expression in childhood malignant extracranial germ-cell tumors.

Oncoimmunology 2019 13;8(2):e1542245. Epub 2018 Dec 13.

Department of Oncohaematology, IRCCS, Ospedale Pediatrico Bambino Gesù, Rome, Italy.

Although pediatric malignant extracranial germ-cell tumors (meGCTs) are among the most chemosensitive solid tumors, a group of patients relapse and die of disease. To identify new markers predicting clinical outcome, we examined the prognostic relevance of tumor-infiltrating T lymphocytes (TILs) and the expression of PD-1 and PD-L1 in a cohort of pediatric meGCTs by immunohistochemistry. MeGCTs were variously infiltrated by T cell-subtypes according to the tumor subtype, tumor location and age at diagnosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/2162402X.2018.1542245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343784PMC
December 2018
1 Read

Endoscopic Transnasal Resection of Suprasellar Teratoma.

J Neurol Surg A Cent Eur Neurosurg 2019 Feb 1. Epub 2019 Feb 1.

Division of Neurosurgery, Department of Surgery, King Saud University, Riyadh, Riyadh Province, Saudi Arabia.

Background:  Intracranial teratomas are rare tumors that usually present during the second decade of life. Among intracranial teratomas, suprasellar germ cell tumors in particular are extremely rare. We present the case of an 18-year-old girl who underwent a successful endoscopic transnasal resection of a suprasellar teratoma with a mixed germ cell component. Read More

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1676624
Publisher Site
http://dx.doi.org/10.1055/s-0038-1676624DOI Listing
February 2019
3 Reads
0.493 Impact Factor

Hepatoid Variant of Yolk Sac Tumor of Both Ovaries with Widespread Intraabdominal and Lung Metastasis: A Case Report.

Iran J Pathol 2018 17;13(2):289-293. Epub 2018 Jul 17.

Dept. of Obstetrics and Gynaecology, Melaka Manipal Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Hepatoid variant of yolk sac tumor of ovary is an unusual tumor with an aggressive behavior. It is usually observed in young females, presents with abdominal complaints and is associated with raised α-fetoprotein (AFP) levels. It should be differentiated from other hepatoid tumors involving the ovary. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339500PMC
July 2018
1 Read

Unedited microneurosurgery of a mixed germ cell tumor of the pineal region.

Surg Neurol Int 2018 24;9:262. Epub 2018 Dec 24.

International Center for Neurosurgery, Henan Provincial People's Hospital, Zhengzhou, China.

Background: Germ cell tumors comprise a heterogeneous group of neoplasms, classified as germinomas and nongerminomatous germ cell tumors based on clinicopathological features. The nongerminomatous group of tumors includes embryonal carcinoma, endodermal sinus tumor (yolk sac tumor), choriocarcinoma, mature and immature teratoma, and mixed germ cell tumors with more than one element. While germinomas are radiation-sensitive tumors, all other tumors have less response to radiotherapy, and it is suggested that gross total resection improves their overall survival and tumor-free survival rates. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/sni.sni_357_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322164PMC
December 2018
1 Read

Experience of applying cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for ovarian teratoma with malignant transformation and peritoneal dissemination.

Ther Clin Risk Manag 2019 14;15:129-136. Epub 2019 Jan 14.

Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan,

Objectives: The prognosis of ovarian teratoma with malignant transformation and peritoneal dissemination (PD) is poor. This condition is rare but associated with a high recurrence rate even after aggressive debulking surgery and adjuvant chemotherapy. In the present paper, we describe our experience of using cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) for this condition. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/TCRM.S190641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338109PMC
January 2019
2 Reads

Are omentectomy and lymphadenectomy necessary in patients with apparently early-stage malignant ovarian germ cell tumors?

Int J Gynecol Cancer 2019 Jan 23. Epub 2019 Jan 23.

Department of Gynecologic Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China

Objective: To evaluate the role of omentectomy and lymphadenectomy in the treatment of clinically apparent early-stage malignant ovarian germ cell tumors.

Methods: We retrospectively reviewed 245 patients with malignant ovarian germ cell tumors (yolk sac tumor, dysgerminoma, and immature teratoma) and with clinically early-stage disease, who were treated at Sun Yat-sen University Cancer Center between January 1, 1970 and December 31, 2017. The survival of patients who underwent either omentectomy or lymphadenectomy, or both (omentectomy/lymphadenectomy group) was compared with that of patients who did not undergo omentectomy or lymphadenectomy (non-omentectomy/lymphadenectomy group). Read More

View Article

Download full-text PDF

Source
http://ijgc.bmj.com/lookup/doi/10.1136/ijgc-2018-000078
Publisher Site
http://dx.doi.org/10.1136/ijgc-2018-000078DOI Listing
January 2019
3 Reads

New Anti-Cancer Strategies in Testicular Germ Cell Tumors.

Recent Pat Anticancer Drug Discov 2019 Jan 11. Epub 2019 Jan 11.

Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Scuola di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli #39;Federico II', Naples. Italy.

Background: The most common solid malignancy of young men aged 20 to 34 years is testicular germ cell tumor. In addition, the incidence of these tumors has significatively increased throughout the last years. Testicular germ cell tumors are classified into seminoma and nonseminoma germ cell tumors, which take in yolk sac tumor, embryonal cell carcinoma, choriocarcinoma, and teratoma. Read More

View Article

Download full-text PDF

Source
http://www.eurekaselect.com/168893/article
Publisher Site
http://dx.doi.org/10.2174/1574892814666190111120023DOI Listing
January 2019
14 Reads

Presacral masses and sacrococcygeal teratomas in patients with and without anorectal malformations: A single institution comparative study.

J Pediatr Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Surgery, Division of Pediatric Surgery, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH. Electronic address:

Background: Despite variability at presentation, presacral masses in patients with and without anorectal malformations (ARM) appear histologically similar. The purpose of this study was to identify differences in oncologic outcomes between these two groups.

Methods: A retrospective review was performed utilizing our institutional cancer and colorectal and pelvic reconstruction databases for patients with presacral masses and sacrococcygeal teratomas between 1990 and 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpedsurg.2018.11.009DOI Listing
December 2018
1 Read
1.311 Impact Factor

Recurrent ovarian mixed germ cell tumor with unusual malignant transformation: a case report.

J Ovarian Res 2019 Jan 10;12(1). Epub 2019 Jan 10.

Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, 201, Section 2, Shih-Pai Road, Taipei, 112, Taiwan, Republic of China.

Background: The value of this report is the identification of late recurrence with an extremely unusual combination of malignant transformation. In particular, the retroconversion of immature to mature teratoma as well as a somatic-type malignant transformation were both observed postchemotherapeutically in our case.

Case Presentation: We report the case of a 20-year-old girl who completed fertility-sparing surgery and chemotherapy under the diagnosis of ovarian mixed germ cell tumor (immature teratoma and yolk sac tumor) and experienced subsequent recurrence 4 years after a second debulking surgery with a somatic type malignant transformation (teratoma with melanoma and leiomyosarcoma). Read More

View Article

Download full-text PDF

Source
https://ovarianresearch.biomedcentral.com/articles/10.1186/s
Publisher Site
http://dx.doi.org/10.1186/s13048-018-0476-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327407PMC
January 2019
5 Reads

Virilization in a Girl Caused by an Ovarian Yolk Sac Tumor: A Case Report.

Authors:
Min Yang Ying Xin

J Pediatr Adolesc Gynecol 2019 Jan 7. Epub 2019 Jan 7.

Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China. Electronic address:

Introduction: Yolk sac tumors (YSTs) are rare malignancies that originate from germ cells and rarely present with endocrine symptoms. We report a case of a 13-year-old girl with a YST manifesting as virilization.

Case Report: A 13-year-old girl was diagnosed as a YST with endocrine symptoms because of Leydig cells in the stroma, which were identified by HE staining and immunohistochemistry. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10833188193000
Publisher Site
http://dx.doi.org/10.1016/j.jpag.2019.01.001DOI Listing
January 2019
6 Reads

Hepatoid Carcinoma of the Ovary: Clinical, Histopathologic, and Immunophenotypic Features.

Arch Pathol Lab Med 2019 Jan 10. Epub 2019 Jan 10.

From the University of Illinois at Chicago (Dr Acosta); the Chicago Medical School of Rosalind Franklin University of Medicine and Science, North Chicago, Illinois (Dr Pins); and the Advocate Lutheran General Hospital and the James R. & Helen D. Russell Institute for Research & Innovation, Park Ridge, Illinois (Dr Pins).

Hepatoid carcinoma of the ovary (HCO) is a rare malignant tumor of uncertain histogenesis that was first described by Ishikura and Scully in the late 1980s. Unlike hepatoid yolk sac tumor (HYST), one of its main differential diagnoses, HCO usually presents in perimenopausal and postmenopausal women without gonadal dysgenesis. Most cases show advanced local disease at initial presentation, with diffuse intraperitoneal dissemination. Read More

View Article

Download full-text PDF

Source
http://www.archivesofpathology.org/doi/10.5858/arpa.2017-048
Publisher Site
http://dx.doi.org/10.5858/arpa.2017-0485-RSDOI Listing
January 2019
5 Reads

More Than a Tumor Marker…A Potential Role for Alpha-Feto Protein in Inflammatory Bowel Disease.

Inflamm Bowel Dis 2019 Jan 8. Epub 2019 Jan 8.

Northwestern University, Feinberg School of Medicine, Chicago Illinois.

Background: Human alpha-fetoprotein (hAFP) is a glycoprotein derived from the gut entoderm and expressed sequentially by cells of the yolk sac, fetal liver, and gastrointestinal tract. By adulthood, serum levels of alpha-fetoprotein (AFP) are undetectable in healthy, nonpregnant adults. Despite the clinical utilities of AFP monitoring in pregnancy and malignancy, much remains to be determined regarding its potential physiological functions. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/ibdjournal/advance-article/doi/10.1
Publisher Site
http://dx.doi.org/10.1093/ibd/izy394DOI Listing
January 2019
9 Reads

Primary Gastric Yolk Sac Tumour.

Sultan Qaboos Univ Med J 2018 Aug 19;18(3):e383-e385. Epub 2018 Dec 19.

Department of Radiology & Molecular Imaging, Sultan Qaboos University Hospital, Muscat, Oman.

Primary gastric yolk tumours are extremely rare. We report a 52-year-old male who presented to the Sultan Qaboos University Hospital, Muscat, Oman, in 2017 after having undergone a gastrectomy abroad due to a suspected poorly-differentiated adenocarcinoma. The patient subsequently returned to Oman to receive chemotherapy. Read More

View Article

Download full-text PDF

Source
https://journals.squ.edu.om/index.php/squmj/article/view/286
Publisher Site
http://dx.doi.org/10.18295/squmj.2018.18.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307656PMC
August 2018
3 Reads

Microglia are effector cells of CD47-SIRPα antiphagocytic axis disruption against glioblastoma.

Proc Natl Acad Sci U S A 2019 Jan 2;116(3):997-1006. Epub 2019 Jan 2.

Division of Pediatric Neurosurgery, Department of Neurosurgery, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, CA 94305;

Glioblastoma multiforme (GBM) is a highly aggressive malignant brain tumor with fatal outcome. Tumor-associated macrophages and microglia (TAMs) have been found to be major tumor-promoting immune cells in the tumor microenvironment. Hence, modulation and reeducation of tumor-associated macrophages and microglia in GBM is considered a promising antitumor strategy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1721434116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338872PMC
January 2019
19 Reads

Honokiol Eliminates Glioma/Glioblastoma Stem Cell-Like Cells Via JAK-STAT3 Signaling and Inhibits Tumor Progression by Targeting Epidermal Growth Factor Receptor.

Cancers (Basel) 2018 Dec 26;11(1). Epub 2018 Dec 26.

Center for Neuroscience, Shantou University Medical College, 22 Xin Ling Road, Shantou, Guangdong 515041, China.

Malignant gliomas are the most aggressive forms of brain tumors; whose metastasis and recurrence contribute to high rates of morbidity and mortality. Glioma stem cell-like cells are a subpopulation of tumor-initiating cells responsible for glioma tumorigenesis, metastasis, recurrence and resistance to therapy. Epidermal growth factor receptor (EGFR) has been reported to be dysregulated in most cancers, including gliomas and its functions are closely linked to initiating tumor metastasis and a very poor prognosis. Read More

View Article

Download full-text PDF

Source
http://www.mdpi.com/2072-6694/11/1/22
Publisher Site
http://dx.doi.org/10.3390/cancers11010022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356849PMC
December 2018
8 Reads

Successful yolk-sac tumor treatment with fertility-sparing partial oophorectomy.

Gynecol Oncol Rep 2019 Feb 30;27:22-24. Epub 2018 Nov 30.

Department of OB/GYN, Division of Gynecologic Oncology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.

Yolk-sac tumors account for about 20% of ovarian germ cell tumors and occur predominantly in women below 35 years of age. Modern evidence-based treatment strategies have ensured long term post-treatment survival, but with increased survival, attention has been turned to an urgent need for developing fertility sparing treatment strategies. In this report we describe the successful treatment of a young woman who was able to conceive and deliver two children, in spite of the loss of one ovary two years prior to being diagnosed with an ovarian yolk-sac tumor on the remaining ovary. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gore.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293018PMC
February 2019
2 Reads

Rapidly growing juvenile granulosa cell tumor of the ovary arising in adult: a case report and review of the literature.

J Ovarian Res 2018 Dec 14;11(1):100. Epub 2018 Dec 14.

Department of Radiology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki City, Osaka, 569-8686, Japan.

Background: Ovarian granulosa cell tumors (GCTs) are divided into adult GCT (AGCT) and juvenile GCT (JGCT). The AGCT is more common type, conversely, less than 5% of tumors are the JGCT and occur in mainly premenarchal girls and in women younger than 30 years. Although JGCT have different histologic features compared to AGCT, the two types have similar imaging features because they have similar gross appearance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13048-018-0474-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293549PMC
December 2018
2 Reads

Relapse in children with clinical stage I testicular yolk sac tumors after initial orchiectomy.

Pediatr Surg Int 2018 Dec 11. Epub 2018 Dec 11.

State Key Laboratory of Oncology in South China, Department of Urology, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, Guangdong, China.

Purpose: To evaluate risk factors of relapse in pediatric patients with clinical stage I (CS1) testicular yolk sac tumors.

Methods: With retrospective analysis, the medical records of children with pure testicular yolk sac tumors who were referred to Sun Yat-sen University Cancer Center and The First Affiliated Hospital from January 1995 to December 2015 were selected and recorded. Histopathology and staging were retrieved and multivariate analysis was performed with SPSS 20. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00383-018-04426-5
Publisher Site
http://dx.doi.org/10.1007/s00383-018-04426-5DOI Listing
December 2018
8 Reads

Clinicopathological Significance and Antitumor Effect of MPHOSPH1 in Testicular Germ Cell Tumor.

J Cancer 2018 31;9(23):4440-4448. Epub 2018 Oct 31.

Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

MPHOSPH1, which is one of the kinesin superfamily proteins, has been reported to play an essential role in the carcinogenesis and progression of several kinds of cancers. MPHOSPH1 has also been suggested to be involved in STAT3 phosphorylation in hepatocellular carcinoma. However, the biological behavior of MPHOSPH1 in testicular germ cell tumors (TGCTs) is unclear at present. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/jca.25279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277652PMC
October 2018
2 Reads

Placental Macrophages: A Window Into Fetal Microglial Function in Maternal Obesity.

Int J Dev Neurosci 2018 Nov 20. Epub 2018 Nov 20.

Pediatrics and Program in Neuroscience, Harvard Medical School; Lurie Center for Autism, MassGeneral Hospital for Children. Electronic address:

Fetal placental macrophages and microglia (resident brain macrophages) have a common origin in the fetal yolk sac. Yolk-sac-derived macrophages comprise the permanent pool of brain microglia throughout an individual's lifetime. Inappropriate fetal microglial priming may therefore have lifelong neurodevelopmental consequences, but direct evaluation of microglial function in a living fetus or neonate is impossible. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijdevneu.2018.11.004DOI Listing
November 2018
10 Reads

Is fertility sparing surgery a treatment option for young patients with yolk sac tumor?

Minerva Ginecol 2018 Dec;70(6):750-753

First Department of Surgery, General Hospital of Attica "KAT", Athens, Greece -

Yolk sac tumor (YST) is the third most frequent ovarian germ cell type ovarian tumor. YST occurs primarily in young girls and in women at reproductive age and thus, the preservation of fertility is considered to be a crucial option if possible for these patients. Compared to previous years, the use of innovative chemotherapeutic regimens in the treatment of YSTs improved significantly the prognosis and outcomes of this rare type of neoplasia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.23736/S0026-4784.18.04194-1DOI Listing
December 2018
10 Reads

Carcinogenesis: the cancer cell-mast cell connection.

Inflamm Res 2019 Feb 20;68(2):103-116. Epub 2018 Nov 20.

Department of Surgery, School of Medicine, Complutense University of Madrid, Plaza de Ramón y Cajal s.n., 28040, Madrid, Spain.

Background: In mammals, inflammation is required for wound repair and tumorigenesis. However, the events that lead to inflammation, particularly in non-healing wounds and cancer, are only partly understood.

Findings: Mast cells, due to their great plasticity, could orchestrate the inflammatory responses inducing the expression of extraembryonic programs of normal and pathological tissue formation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00011-018-1201-4DOI Listing
February 2019
11 Reads

Yolk Sac Tumor of Stomach: Case Report and Review of Literature.

J Indian Assoc Pediatr Surg 2018 Oct-Dec;23(4):232-233

Department of Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Gastric yolk sac tumors (YSTs) are very rare. Only seven cases of pure YST of the stomach, with a median age of 65 years, and five cases of YST combined with adenocarcinoma have been reported. We report a 3-year-old boy who presented to us with recurrent episodes of melena and anemia of 2 months' duration. Read More

View Article

Download full-text PDF

Source
http://www.jiaps.com/text.asp?2018/23/4/232/242709
Publisher Site
http://dx.doi.org/10.4103/jiaps.JIAPS_17_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182937PMC
November 2018
10 Reads

Teratoma in the Hepatoduodenal Ligament.

J Indian Assoc Pediatr Surg 2018 Oct-Dec;23(4):228-231

Department of Pediatric Surgery and Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India.

A teratoma is not an uncommon tumor in the pediatric age group. It has a predilection for specific sites, but a teratoma arising from the hepatoduodenal ligament (HDL) is very rare. Only 15 cases of HDL teratoma have been reported so far. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/jiaps.JIAPS_36_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182942PMC
November 2018
2 Reads

A primary germ cell tumour in the gastrointestinal tract: a caecal lesion of yolk-sac morphology in a young patient.

J Surg Case Rep 2018 Nov 1;2018(11):rjy291. Epub 2018 Nov 1.

Department of Surgery, John Hunter Hospital, New Lambton Road, New Lambton Heights, Australia.

A 24-year-old man with a history of Crohns disease, whilst undergoing surveillance colonoscopy was found to have an ulcerated caecal lesion. The histopathology from the mucosal biopsy was suggestive of a yolk sac tumour. After thorough re-examination, the patient had no radiological evidence of malignancy in his testes or retroperitoneum. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/jscr/article/doi/10.1093/jscr/rjy29
Publisher Site
http://dx.doi.org/10.1093/jscr/rjy291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210665PMC
November 2018
9 Reads

Peritoneal Carcinomatosis From Yolk Sac Tumor in a Postmenopausal Woman Following Chemotherapy for High-grade Ovarian Serous Carcinoma.

Int J Gynecol Pathol 2018 Oct 31. Epub 2018 Oct 31.

Department of Woman and Child Health, Fondazione Policlinico Universitario A. Gemelli IRCCS-Università Cattolica del Sacro Cuore, Rome, Italy.

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00004347-900000000-9914
Publisher Site
http://dx.doi.org/10.1097/PGP.0000000000000562DOI Listing
October 2018
18 Reads

CK7, inhibin, and p63 in testicular germ cell tumor: superior markers of Choriocarcinoma compared to β-hCG.

Hum Pathol 2018 Oct 22. Epub 2018 Oct 22.

Department of Pathology, The Ohio State University Medical Center, 410 W 10(th) Ave., 401 Doan Hall, Columbus, OH 43210. Electronic address:

Choriocarcinoma can be difficult to differentiate from other subtypes of testicular germ cell tumor and can occur unexpectedly in a distant, late metastasis. The aim of this investigation was to identify a marker superior to β-hCG for choriocarcinoma. 62 primary and metastatic testicular germ cell tumors (27 choriocarcinomas, 19 yolk sac tumors, 29 embryonal carcinomas, 28 seminomas, 22 teratomas, 3 epithelioid trophoblastic tumors (ETT)), were analyzed for immunohistochemical expression of CK7, inhibin, p63, and β-hCG. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00468177183039
Publisher Site
http://dx.doi.org/10.1016/j.humpath.2018.10.007DOI Listing
October 2018
9 Reads
2.770 Impact Factor

N-cadherin expression in primary and metastatic testicular germ cell tumors.

J BUON 2018 Jul-Aug;23(4):1125-1129

Department of Surgical Pathology, Uludag University School of Medicine, Bursa, Turkey.

Purpose: Upregulation of N-cadherin in epithelial tumor cells has been reported to enhance the invasive process. Although the distribution of N-cadherin in the normal testis was demonstrated, there is no adequate information regarding its presence in testicular germ cell tumors (GCTs). Our purpose was to examine the expression and localization of N-cadherin in germ cell tumors of the testis and share our experience. Read More

View Article

Download full-text PDF

Source
October 2018
4 Reads

Malignant mixed ovarian germ cell tumor composed of immature teratoma, yolk sac tumor and embryonal carcinoma harboring an EGFR mutation: a case report.

Onco Targets Ther 2018 12;11:6853-6862. Epub 2018 Oct 12.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China,

Malignant mixed ovarian germ cell tumors are very rare, accounting for ~5.3% of all malignant ovarian germ cell tumors (MOGCTs), with a very high degree of malignancy. The treatment of patients with persistent, refractory, or platinum-resistant MOGCT is not well defined. Read More

View Article

Download full-text PDF

Source
https://www.dovepress.com/malignant-mixed-ovarian-germ-cell-
Publisher Site
http://dx.doi.org/10.2147/OTT.S176854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190639PMC
October 2018
4 Reads

Prepubertal testicular tumors in China: a 10-year experience with 67 cases.

Pediatr Surg Int 2018 Dec 15;34(12):1339-1343. Epub 2018 Oct 15.

Department of Pediatric Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.

Aim: Prepubertal testicular tumors are rare in children. We aim to present clinical and histological features of prepubertal testicular tumors through the analysis of the long-term experiences of a single medical center of China.

Materials And Methods: A total of 67 children (≤ 14 years) treated for testicular tumor at our institution from 2005 to 2015 were retrospectively reviewed. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00383-018-4366-6
Publisher Site
http://dx.doi.org/10.1007/s00383-018-4366-6DOI Listing
December 2018
12 Reads

Primary Central Nervous System Germ Cell Tumors: A Review and Update.

Med Res Arch 2018 Mar 15;6(3). Epub 2018 Mar 15.

Department of Neurosurgery, Indiana University School of Medicine, IUPUI, Indiana, USA.

Importance: Primary central nervous system (CNS) germ cell tumors (GCT) are a heterogeneous group of tumors that are still poorly understood. In North America, GCTs comprise approximately 1% of primary brain tumors in pediatric and young adult patients. GCTs can occur as pure or mixed subtypes; they are divided into germinomas, which are the most common subtype, and non-germinomatous germ cell tumors (NGGCTs), which consist of approximately one-third of GCTs and include teratomas, embryonal carcinomas, choriocarcinomas, and yolk sac tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18103/mra.v6i3.1719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157918PMC
March 2018
13 Reads

Robot-assisted inguinal sentinel lymph node biopsy in primary yolk sac tumor of the vulva.

Surg Oncol 2018 Sep 8;27(3):520. Epub 2018 Jun 8.

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

Background: Primary yolk sac tumor (YST) of the vulva is extremely rare and only introduced in case reports [1]. For those, routine inguinal lymph node dissection (LND) in absence of palpable inguinal lymph node is questionable. To avoid complications of inguinal LND, such as lymphedema, inguinal sentinel lymph node biopsy (SLNB) can be considered [2,3]. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09607404173038
Publisher Site
http://dx.doi.org/10.1016/j.suronc.2018.05.035DOI Listing
September 2018
13 Reads

Alpha-fetoprotein-producing rectal cancer successfully responded to preoperative chemoradiotherapy: case report.

Surg Case Rep 2018 Sep 6;4(1):111. Epub 2018 Sep 6.

Second Department of Surgery, School of Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama, 641-8510, Japan.

Background: Alpha-fetoprotein (AFP) is produced by some tumors, such as hepatocellular carcinoma and yolk sac tumors, leading to an increase in serum AFP level. However, AFP in colorectal cancer is extremely rare. Treatment for AFP-producing cancer is often performed according to conventional methods, but oncological outcomes of both surgery and chemotherapy are poor. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40792-018-0520-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127073PMC
September 2018
2 Reads

Clinicopathologic Features and Chromosome 12p Status of Pediatric Sacrococcygeal Teratomas: A Multi-institutional Analysis.

Pediatr Dev Pathol 2018 Sep 3:1093526618798771. Epub 2018 Sep 3.

3 Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts.

Chromosome 12p gains are typically present in postpubertal male patients with testicular malignant germ cell tumors, including most teratomas, and absent in pure ovarian teratomas, both mature and immature. We sought to evaluate the clinicopathologic features and chromosome 12p status of pediatric patients with sacrococcygeal teratomas (SCTs) using the institutional databases of 2 tertiary medical centers. Seven mature teratomas (3 pure, 2 with yolk sac tumor, 1 with medulloepithelioma, and 1 with ependymoma) and 3 immature teratomas (2 pure: grade 2 and grade 3 and 1 mixed: grade 3 with yolk sac tumor) were identified. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526618798771DOI Listing
September 2018
6 Reads

The genetic landscape of 87 ovarian germ cell tumors.

Gynecol Oncol 2018 10 28;151(1):61-68. Epub 2018 Aug 28.

Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium; Division of Gynaecological Oncology, Leuven Cancer Institute, Kuleuven, Herestraat 49, 3000 Leuven, Belgium. Electronic address:

Background: Ovarian germ cell tumors (OGCT) are rare gynecological neoplasms, mostly affecting children and young women. The underlying molecular genetic background of these tumors is poorly characterized.

Methods: We analyzed somatic copy number aberration (CNA) profiles in 87 OGCT tumors and performed whole exome sequencing (WES) on 24 OGCT tumor and matched germline samples to further elucidate their molecular genetic landscape. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00908258183113
Publisher Site
http://dx.doi.org/10.1016/j.ygyno.2018.08.013DOI Listing
October 2018
17 Reads

c-MET receptor as potential biomarker and target molecule for malignant testicular germ cell tumors.

Oncotarget 2018 Aug 7;9(61):31842-31860. Epub 2018 Aug 7.

Department of Anatomy, Histology, Forensic-Medicine and Orthopaedics, "Sapienza" University of Rome, Italy.

Type II testicular germ cell tumors (TGCTs) represent the most frequent malignancy in Caucasian males (20-40 years). Even if diagnosed with disseminated disease, >80% of patients are cured; however, a small percentage of cases progress and result in death. It is commonly accepted that these cancers arise from a disturbed testicular embryonic niche that leads to the block of gonocyte differentiation. Read More

View Article

Download full-text PDF

Source
http://www.oncotarget.com/fulltext/25867
Publisher Site
http://dx.doi.org/10.18632/oncotarget.25867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112764PMC
August 2018
13 Reads

Ovarian yolk sac tumor in postmenopausal females: A case series and a literature review.

Medicine (Baltimore) 2018 Aug;97(33):e11838

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Rationale: Ovarian yolk sac tumors (YSTs) are the second most common histologic type of ovarian germ cell tumors. Most patients are adolescent and young women, while cases in postmenopausal women were rarely reported. Due to its rarity, we know little about the treatment and prognosis of postmenopausal patients with ovarian YSTs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000011838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112915PMC
August 2018
20 Reads

Assessment of Toxicity and Absorption of the Novel AA Derivative AA-Pme in SGC7901 Cancer Cells In Vitro and in Zebrafish In Vivo.

Med Sci Monit 2018 Aug 4;24:5412-5421. Epub 2018 Aug 4.

Center for New Drug Research and Development, College of Life Science, Nanjing Normal University, Nanjing, Jiangsu, China (mainland).

BACKGROUND Asiatic acid (AA; 2α,3β,23-trihydroxyurs-12-ene-28-oic acid) is an active compound derived from Centella asiatica, a traditional medicinal plant used widely in many Asian countries, particularly for the treatment of cancer. However, the modified AA derivative N-(2α,3β,23-acetoxyurs-12-en-28-oyl)-l-proline methyl ester (AA-PMe) has shown markedly better anti-tumor activity than AA. MATERIAL AND METHODS We evaluated the toxicity of AA and AA-PMe on zebrafish morphology, mortality, and hatching rate and determined the effect on SGC7901 cancer cells by acute toxicity assay. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.909606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088512PMC
August 2018
4 Reads

Central Nervous System-type Neuroepithelial Tumors and Tumor-like Proliferations Developing in the Gynecologic Tract and Pelvis: Clinicopathologic Analysis of 23 Cases.

Am J Surg Pathol 2018 Nov;42(11):1429-1444

Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD.

Central nervous system (CNS)-type tumors and tumor-like proliferations arising in the gynecologic tract and pelvis are rare. Clinicopathologic features of 23 cases are reported using the current WHO classification system for CNS tumors, with selected relevant immunohistochemical and molecular genetic analyses when possible. There were 12 embryonal tumors, including 7 medulloepitheliomas, 2 embryonal tumors (not otherwise specified), 1 embryonal tumor with multilayered rosettes, 1 embryonal tumor with features of nodular desmoplastic medulloblastoma, and 1 medulloblastoma with extensive nodularity, with primary sites including ovary (7), uterus/endometrium (3), and pelvis (2). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PAS.0000000000001131DOI Listing
November 2018
11 Reads

Testicular germ cell tumors: revisiting a series in light of the new WHO classification and AJCC staging systems, focusing on challenges for pathologists.

Hum Pathol 2018 Dec 21;82:113-124. Epub 2018 Jul 21.

Department of Pathology, Portuguese Oncology Institute of Porto (IPOP), R. Dr. António Bernardino de Almeida, 4200-072, Porto, Portugal; Cancer Biology and Epigenetics Group, Research Center of Portuguese Oncology Institute of Porto (GEBC CI-IPOP), R. Dr. António Bernardino de Almeida, 4200-072, Porto, Portugal; Department of Pathology and Molecular Immunology, Institute of Biomedical Sciences Abel Salazar, University of Porto (ICBAS-UP), Rua Jorge Viterbo Ferreira 228, 4050-513, Porto, Portugal. Electronic address:

Testicular germ cell tumors (TGCTs) are strikingly heterogeneous, reflecting a complex tumor model, posing serious challenges for pathologists. Accurate classification and staging, according to most recent systems, is fundamental. We aimed to revise a series of consecutively diagnosed TGCTs (2005-2016) in light of the new World Health Organization (WHO) classification and American Joint Committee on Cancer (AJCC) staging systems, discussing dilemmas imposed to pathologists. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.humpath.2018.07.016DOI Listing
December 2018
11 Reads

[Pathologic features on gonadal changes of sexual developmental disorders in children].

Zhonghua Bing Li Xue Za Zhi 2018 Jul;47(7):531-535

Department of Pediatric Endocrinology, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China.

To investigate the pathologic features of gonadal tissues of disorders of sexual development (DSD) in children. Fifty-three cases of gonadal developmental disorders were collected from July 2015 to August 2017 at Guangzhou Women and Children's Medical Center. Clinical manifestations, karyotypes, sex hormone levels, ultrasound imaging, histology and immunophenotype of gonadal tissues were analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.07.010DOI Listing
July 2018
20 Reads

Mixed extragonadal germ cell tumour of the prostate.

BMJ Case Rep 2018 Jul 10;2018. Epub 2018 Jul 10.

Department of Urology and Renal Transplantation, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal.

Extragonadal germ cell tumours (EGGCTs) originated in prostate are extremely rare, with <20 cases described in the literature. We report a case of a patient with a primary prostatic mixed EGGCT. A 47-year-old man presenting severe low urinary tract symptoms and signs of prostatic enlargement, with no malignancy suspicion, underwent transurethral resection of the prostate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2017-223603DOI Listing
July 2018
17 Reads

Differentiation-Dependent Regulation of Human Endogenous Retrovirus K Sequences and Neighboring Genes in Germ Cell Tumor Cells.

Front Microbiol 2018 15;9:1253. Epub 2018 Jun 15.

Department of Surgical and Conservative Paediatrics and Adolescent Medicine, Martin Luther University Halle-Wittenberg, Halle, Germany.

Under physiological conditions, most human endogenous retroviruses (HERVs) are transcriptionally silent. However, re-activation of HERVs is observed under pathological conditions like inflammation or cancer. In addition to expression of HERV sequences, an impact of HERV-loci on expression of adjacent genes has been suggested as probably important patho-physiological mechanism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2018.01253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013571PMC
June 2018
29 Reads

[Imaging of abdominal tumors in childhood and adolescence : Part II: relevant intra-abdominal and retroperitoneal tumor entities].

Radiologe 2018 Jul;58(7):673-686

Sektion Pädiatrische Radiologie, Institut für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Deutschland.

Abdominal and pelvic tumors in children and adolescents can be manifested intra-abdominally and also often in the retroperitoneum. The most important pediatric primary retroperitoneal space-occupying lesions are nephroblastoma (Wilms' tumor) and neuroblastoma, whereby imaging plays a decisive role in the diagnostics and differentiation of the two entities. Benign tumors of the mesentery and gastrointestinal tract occur more frequently in children than malignant lesions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00117-018-0410-8DOI Listing
July 2018
41 Reads