21,817 results match your criteria Yolk Sac Tumor


In vivo monitoring of intracellular Ca dynamics in the pancreatic β-cells of zebrafish embryos.

Islets 2018 Dec 6:1-18. Epub 2018 Dec 6.

a Institute of Molecular Biology/CMBI , University of Innsbruck , Innsbruck , Austria.

Assessing the response of pancreatic islet cells to glucose stimulation is important for understanding β-cell function. Zebrafish are a promising model for studies of metabolism in general, including stimulus-secretion coupling in the pancreas. We used transgenic zebrafish embryos expressing a genetically-encoded Ca sensor in pancreatic β-cells to monitor a key step in glucose induced insulin secretion; the elevations of intracellular [Ca]. Read More

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December 2018
1 Read

Clinicopathological Significance and Antitumor Effect of MPHOSPH1 in Testicular Germ Cell Tumor.

J Cancer 2018 31;9(23):4440-4448. Epub 2018 Oct 31.

Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

MPHOSPH1, which is one of the kinesin superfamily proteins, has been reported to play an essential role in the carcinogenesis and progression of several kinds of cancers. MPHOSPH1 has also been suggested to be involved in STAT3 phosphorylation in hepatocellular carcinoma. However, the biological behavior of MPHOSPH1 in testicular germ cell tumors (TGCTs) is unclear at present. Read More

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October 2018

Zebrafish embryos exposed to deltamethrin exhibited abnormalities in spite of induced expression of related genes ( you, you-too, momo and u-boot).

Toxicol Ind Health 2018 Dec 5:748233718807046. Epub 2018 Dec 5.

2 Department of Animal Biology, School of life Sciences, University of Hyderabad, Telangana, India.

Evaluation of the toxic effects of a widely used synthetic pyrethroid, deltamethrin (DM), was carried out in this study. This pesticide is preferred for pest control because of its low environmental persistence and toxicity. We investigated the expression pattern of four genes, namely, you ( you), yot ( you-too), momo ( mom) and ubo ( u-boot) during early development of zebrafish, that is, from 12 hpf to 48 hpf stages. Read More

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December 2018
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Induction of IBV strain-specific neutralising antibodies and broad spectrum protection in layer pullets primed with IBV Massachusetts (Mass) and 793B vaccines prior to injection of inactivated vaccine containing Mass antigen.

Avian Pathol 2018 Dec 6:1-27. Epub 2018 Dec 6.

c 138 Hartford Road, Huntingdon, Cambridgeshire , PE29 1XQ , UK .

In an initial study in SPF chickens, a heterologous virus neutralising (VN) antibody response to IBV variants Q1, Variant 2 (Var 2), D388/QX (D388), D274 and Arkansas (DPI) was observed using a vaccination programme incorporating two different live-attenuated IBV vaccines, followed by boosting with an inactivated vaccine containing IBV Massachusetts (Mass) antigen. Therefore, a more detailed study was undertaken in SPF layer-type chickens previously primed with IBV Mass and 793B live-attenuated vaccines. The efficacy of single or repeated vaccination with a multivalent inactivated vaccine containing IBV antigen was determined against challenge with 5 virulent IBVs: Mass (M41), 793B (4/91), D388, Q1 and Var 2. Read More

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December 2018

Embryotoxic effects of in-ovo triclosan injection to the yellow-legged gull.

Chemosphere 2018 Nov 28;218:827-835. Epub 2018 Nov 28.

Department of Environmental Science and Policy, University of Milan, Via Celoria 26, 20133 Milan, Italy. Electronic address:

Triclosan (TCS) is an antimicrobial agent used in diverse personal care products that is considered as an emerging contaminant of both aquatic and terrestrial ecosystems. Although TCS aquatic ecotoxicity is well known, information on the presence and effects on terrestrial organisms is still scarce. This study was aimed at exploring the embryotoxicity of TCS to the yellow-legged gull (Larus michahellis) induced by the in-ovo injection of 150 ng TCS/g egg weight. Read More

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November 2018
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Molecular characterization, expression analysis, and ontogeny of complement component C9 in southern catfish (Silurus meridionalis).

Fish Shellfish Immunol 2018 Nov 30. Epub 2018 Nov 30.

Institute of Hydrobiology, Jinan University, Engineering Research Center of Tropical and Subtropical Aquatic Ecological Engineering Ministry of Education, Key Laboratory of Eutrophication and Red Tide Prevention of Guangdong Higher Education Institutes, West 601 Huangpu Avenue, Tianhe District, Guangzhou, 510632, People's Republic of China.

The complement system plays an important role in host defense against invading microorganisms. Complement component C9 is the last component that is involved in the formation of the membrane attack complex (MAC) on the surface of target cells. In the present study, the full length C9 cDNA sequence of 1984 bp with an open reading frame (ORF) of 1809 bp was cloned from southern catfish (Silurus meridionalis). Read More

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November 2018

Determining the digestible lysine requirement of 22- to 47-week-old Lohmann laying hens using an increasing protein titration methodology.

Poult Sci 2018 Dec 3. Epub 2018 Dec 3.

Poultry Technical Services, LLC, Buford, GA 30518-7015, USA.

A laying hen trial was conducted from 22 to 47 wk of age to determine the digestible lysine (DLYS) requirement of laying hens by using an increasing CP titration method. A total of 896 Lohmann LSL-Lite caged layers (22 wk of age) were allotted to 8 dietary treatments and each treatment had 8 replications of 14 hens. The first 7 experimental diets initially contained DLYS levels increasing from 0. Read More

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December 2018

Effect of early neonatal development and delayed feeding post-hatch on jejunal and ileal calcium and phosphorus transporter genes expression in broiler chickens.

Poult Sci 2018 Dec 3. Epub 2018 Dec 3.

United States Department of Agriculture, Agricultural Research Service, Animal Biosciences and Biotechnology Laboratory, Beltsville, MD 20705, USA.

Calcium (Ca) and phosphorus (P) are essential minerals involved in many biological processes including bone development and mineralization. Plasma concentration of both minerals is tightly regulated, and Ca and P homeostasis is maintained via intestinal absorption, bone storage and exchange, and renal reabsorption. In the current broiler production systems, chicks are deprived of food and water for up to 72 h due to uneven hatching, hatchery procedures, and transportation time to farms. Read More

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December 2018

Ontogeny of urea and ammonia transporters in mahi-mahi (Coryphaena hippurus) early life stages.

Comp Biochem Physiol A Mol Integr Physiol 2018 Nov 29;229:18-24. Epub 2018 Nov 29.

RSMAS, University of Miami, 4600 Rickenbacker Causeway, Miami, FL 33149, United States.

The mechanism(s) of ammonia and urea excretion in freshwater fish have received considerable attention; however, parallel investigations of seawater fish, specifically in the early life stages are scarce. The first objective of this study was to evaluate the patterns of ammonia and urea excretion in mahi-mahi (Coryphaena hippurus) up to 102  hours post fertilization (hpf). Similar to other teleosts, mahi embryos are ureotelic before hatch and gradually switch to being ammoniotelic around the time of hatch. Read More

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November 2018
2 Reads

Microwave spectroscopy based on the waveguide technique for the nondestructive freshness evaluation of egg.

Food Chem 2019 Mar 1;277:558-565. Epub 2018 Nov 1.

Department of Animal Sciences, College of Agriculture, Isfahan University of Technology, Isfahan 84156-83111, Iran.

A rectangular waveguide equipped with a network analyzer was used to assess the quality indices of shell egg. The scattering parameters of the eggs were acquired in the range of 0.9-1. Read More

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Clethodim exposure induces developmental immunotoxicity and neurobehavioral dysfunction in zebrafish embryos.

Fish Shellfish Immunol 2018 Dec 2. Epub 2018 Dec 2.

College of Life Sciences, Jinggangshan University, Ji'an, Jiangxi, China; Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Ji'an, Jiangxi, China; Jiangxi Key Laboratory of Developmental Biology of Organs, Ji'an, Jiangxi, China. Electronic address:

Clethodim is one of the most widely used herbicides in agriculture, but its potential negative effects on aquatic organisms are still poorly understood. This study examined the effects of clethodim on zebrafish at aspects of early stage embryonic development, immune toxicity, cell apoptosis and locomotor behavior. Firstly, clethodim exposure markedly decreased the survival rate, body length, and heart rate and resulted in a series of morphological abnormalities, primarily spinal deformities (SD) and yolk sac edema, in zebrafish larvae. Read More

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December 2018

Insights into soy lecithin and egg yolk-based extenders for chilling canine spermatozoa.

Zygote 2018 Dec 5:1-8. Epub 2018 Dec 5.

University of São Paulo,College of Veterinary Medicine and Animal Science,Department of Animal Reproduction, Cidade Universitária, São Paulo,Brazil.

SummaryThe aim of this study was to compare different concentrations of soy lecithin (LEC0.01%, LEC0.05% and LEC0. Read More

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December 2018

A cargo model of yolk syncytial nuclear migration during zebrafish epiboly.

Development 2018 Dec 3. Epub 2018 Dec 3.

Department of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, USA

In teleost fish, the multinucleate yolk syncytial layer functions as an extraembryonic signaling center to pattern mesendoderm, coordinate morphogenesis and supply nutrients to the embryo. External yolk syncytial nuclei (e-YSN) undergo microtubule dependent movements that distribute the nuclei over the large yolk mass. How e-YSN migration proceeds, and the role of the yolk microtubules is not understood but it is proposed that e-YSN are pulled vegetally as the microtubule network shortens from the vegetal pole. Read More

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December 2018
1 Read

Changes to mineral levels in the yolk of meat chicken embryos during incubation.

Poult Sci 2018 Nov 30. Epub 2018 Nov 30.

Poultry Research Foundation, Faculty of Science, The University of Sydney, Camden, NSW 2570, Australia.

A total of 864 settable Cobb 500 eggs were used to explore changes in yolk mineral content during incubation. Eggs were individually weighed and then placed in a commercial incubator. On embryonic day (ED) 0, 6. Read More

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November 2018
2 Reads

Arterial Identity Of Hemogenic Endothelium: A Key To Unlock Definitive Hematopoietic Commitment In hPSC Cultures.

Exp Hematol 2018 Nov 27. Epub 2018 Nov 27.

National Primate Research Center, University of Wisconsin Graduate School, 1220 Capitol Court, Madison, WI 53715, USA.

Human pluripotent stem cells (hPSCs) have been suggested as a potential source for the de novo production of blood cells for transfusion, immunotherapies and transplantation. However, even with advanced hematopoietic differentiation methods, the primitive and myeloid-restricted waves of hematopoiesis dominate in hPSC differentiation cultures while cell-surface markers to distinguish these waves of hematopoiesis from lympho-myeloid hematopoiesis remain unknown. In the embryo, hematopoietic stem cells (HSCs) arise from hemogenic endothelium (HE) lining arteries, but not veins. Read More

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November 2018

In ovo metabolism and yolk glucocorticoid concentration interact to influence embryonic glucocorticoid exposure patterns.

Gen Comp Endocrinol 2018 Nov 27. Epub 2018 Nov 27.

School of Biological Sciences, Illinois State University, Normal, IL 61790, USA. Electronic address:

Vertebrates release glucocorticoids during stressful events. If stress occurs during reproduction, the resulting offspring can show altered phenotypes that are thought to arise from increased exposure to maternal glucocorticoids. Developing offspring can metabolize maternal glucocorticoids, which can alter the pattern of exposure they encounter. Read More

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November 2018

Spermatozoa Cryopreservation: State of Art and Future in Small Ruminants.

Biopreserv Biobank 2018 Nov 30. Epub 2018 Nov 30.

1 Yunnan Animal Science and Veterinary Institute , Kunming, China .

The cryotolerance of farm animal spermatozoa varies according to their specific features, such as size, shape, and lipid composition. Thus, it is impossible to develop a standardized freezing procedure for different kinds of livestock species. The establishment of an efficient semen cryopreservation procedure will facilitate long-term conservation of small ruminant genetic resources and extension of artificial insemination in daily production. Read More

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November 2018
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Microglia in Alzheimer's Disease: Risk Factors and Inflammation.

Front Neurol 2018 15;9:978. Epub 2018 Nov 15.

Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Microglia are resident immune cells in the central nervous system (CNS) that originate from myeloid progenitor cells in the embryonic yolk sac and are maintained independently of circulating monocytes throughout life. In the healthy state, microglia are highly dynamic and control the environment by rapidly extending and retracting their processes. When the CNS is inflamed, microglia can give rise to macrophages, but the regulatory mechanisms underlying this process have not been fully elucidated. Read More

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November 2018

Methoprene-Tolerant (Met) Is Indispensable for Larval Metamorphosis and Female Reproduction in the Cotton Bollworm .

Front Physiol 2018 15;9:1601. Epub 2018 Nov 15.

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China.

Juvenile hormone (JH) represses larval metamorphosis and induces adult reproduction in insects. Methoprene-tolerant (Met) is identified as an intranuclear receptor that mediates JH actions. In the present study, we characterized a Met from the severe agricultural pest, , namely HaMet. Read More

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November 2018

Neurotoxicological effects induced by up-regulation of miR-137 following triclosan exposure to zebrafish (Danio rerio).

Aquat Toxicol 2018 Nov 22;206:176-185. Epub 2018 Nov 22.

Zhejiang Provincial Key Laboratory of Medical Genetics, Key Laboratory of Laboratory Medicine, Ministry of Education, China, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China. Electronic address:

Triclosan (TCS) is a prevalent anthropogenic contaminant in aquatic environments and its chronic exposure can lead to a series of neurotoxic effects in zebrafish. Both qRT-PCR and W-ISH identified that TCS exposure resulted in significant up-regulation of miR-137, but downregulation of its regulatory genes (bcl11aa, MAPK6 and Runx1). These target genes are mainly associated with neurodevelopment and the MAPK signaling pathway, and showed especially high expression in the brain. Read More

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November 2018

Effects of dietary supplementation of alfalfa meal on growth performance, carcass characteristics, meat and egg quality, and intestinal microbiota in Beijing-you chicken.

Poult Sci 2018 Nov 29. Epub 2018 Nov 29.

Beijing Research and Development Center for Grass and Environment, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China.

This study was conducted to investigate the effects of alfalfa meal supplementation on growth performance, carcass characteristics, meat and egg quality, and intestinal microbiota in chickens. A total of 600 healthy 20-wk female Beijing-you chickens (a local Chinese chicken breed) were selected and randomly assigned into 4 dietary treatments: 0, 5, 8, and 10% alfalfa meal supplementation. Chickens were raised in a free-range system for 56 d. Read More

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November 2018
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Remodeling of the endoplasmic reticulum in C. elegans oocytes is regulated by CGH-1.

Genesis 2018 Nov 29:e23267. Epub 2018 Nov 29.

Biology Department, Central Michigan University, Mount Pleasant, MI.

A key aspect of development in all metazoans is remodeling at the cellular level. During the development of gametes, remodeling occurs throughout the germ line. When C. Read More

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November 2018

Effects of Bacillus subtilis C-3102 on production, hatching performance, egg quality, serum antioxidant capacity and immune response of laying breeders.

J Anim Physiol Anim Nutr (Berl) 2018 Nov 28. Epub 2018 Nov 28.

Hunan Songyun Commercial Fowl Company, Huaihua, China.

To investigate the supplemental effects of Bacillus subtilis C-3102 on the production, hatching performance, egg quality, serum antioxidant capacity and immune response of laying breeders, a total of 480 Xuefeng black-bone (25-week-old) hens were randomly assigned into four treatment groups: Hens fed the basal diets with 0 (CON), 3.0 × 10 (BS-1), 6.0 × 10  cfu/g (BS-2) and 9. Read More

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November 2018
3 Reads

The phospholipid fraction obtained from egg yolk reduces blood pressure increase induced by acute stress in spontaneously hypertensive rats.

Adv Clin Exp Med 2018 Nov 28. Epub 2018 Nov 28.

Division of Angiology, Faculty of Health Sciences, Wroclaw Medical University, Poland.

Background: Despite continuous research, an improved understanding of the pathophysiology of hypertension and the development of new antihypertensive therapies, hypertension is still the most prevalent chronic cardiovascular disease (CVD) among adults in Western societies. Stress is a common factor related to cardiovascular morbidity. An increase in blood pressure is one of the most common reactions to stress. Read More

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November 2018
2 Reads

On the Enigma of the Human Neurenteric Canal.

Cells Tissues Organs 2018 Nov 27:1-23. Epub 2018 Nov 27.

Institute of Anatomy and Embryology, University Medical Center Göttingen, Göttingen, Germany.

Existence and biomedical relevance of the neurenteric canal, a transient midline structure during early neurulation in the human embryo, have been controversially discussed for more than a century by embryologists and clinicians alike. In this study, the authors address the long-standing enigma by high-resolution histology and three-dimensional reconstruction using new and historic histological sections of 5 human 17- to 21-day-old embryos and of 2 marmoset monkey embryos of the species Callithrix jacchus at corresponding stages. The neurenteric canal presents itself as the classical vertical connection between the amniotic cavity and the yolk sac cavity and is lined (a) craniolaterally by a horseshoe-shaped "hinge of involuting notochordal cells" within Hensen's node and (b) caudally by the receding primitive streak epiblast dorsally and by notochordal plate epithelium ventrally, the latter of which covered the (longitudinal) notochordal canal on its ventral side at the preceding stage. Read More

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November 2018

Keel bone fractures affect egg laying performance but not egg quality in laying hens housed in a commercial aviary system.

Poult Sci 2018 Nov 27. Epub 2018 Nov 27.

Center for Proper Housing: Poultry and Rabbits (ZTHZ), Animal Welfare Division, VPH Institute, University of Bern, 3052 Zollikofen, Switzerland.

The aim of this study was to investigate the effect of keel bone fracture (KBF) severity and healing activity on individual productivity of laying hens. Focal hens (75 Lohmann Selected Leghorn (LSL), 75 Lohmann Brown (LB)) were housed alongside non-focal hens in 10 identical pens containing a commercial aviary system (15 focal hens per pen). Eggs of focal hens were identified by orally administering a dye on 3 consecutive days, resulting in a hen-specific color pattern in the yolk. Read More

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November 2018
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Novel placental structure in the Mexican gerrhonotine lizard, Mesaspis viridiflava (Lacertilia; Anguidae).

J Morphol 2018 Nov 26. Epub 2018 Nov 26.

Departamento de Zoologia, Instituto de Biologia, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico.

The evolution of viviparity alters the physical relationship between mothers and offspring and the prevalence of viviparity among squamate reptiles presents an opportunity to uncover patterns in the evolution of placental structure. Understanding the breadth of this diversity is limited because studies of placental structure and function have emphasized a limited number of lineages. We studied placental ontogeny using light microscopy for an embryological series of the Mexican gerrhonotine lizard, Mesaspis viridiflava. Read More

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November 2018

Yolk-Shell Germanium@Polypyrrole Architecture with Precision Expansion Void Control for Lithium Ion Batteries.

iScience 2018 Nov 12;9:521-531. Epub 2018 Nov 12.

Academy of Fundamental and Interdisciplinary Sciences, Harbin Institute of Technology, Harbin 150001, China. Electronic address:

The key properties of yolk-shell architecture in improving electrochemical performance lies in its uniformity and the appropriate void space, which can expand/contract freely upon lithium alloying and leaching without damaging the outer shell, while being achievable with minimal sacrifice of volumetric energy density. Therefore, we developed a highly controllable strategy to fabricate a uniform porous germanium@polypyrrole (PGe@PPy) yolk-shell architecture with conformal AlO sacrificial layer by atomic layer deposition (ALD) process. The PGe@PPy yolk-shell anode fabricated with 300 ALD cycles delivers excellent electrochemical performance: high reversible capacity (1,220 mA hr g), long cycle performance (>95% capacity retention after 1,000 cycles), and excellent rate capability (>750 mA hr g at 32 A g). Read More

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November 2018
3 Reads

Relative reactivity to egg white and yolk or change upon heating as markers for baked egg tolerance.

Pediatr Allergy Immunol 2018 Nov 26. Epub 2018 Nov 26.

INRA, UR 1268 Biopolymères, Interactions, Assemblages, F-44316, Nantes, France.

Background: Hen's egg food allergy is frequent in childhood and phenotypically heterogeneous. Some children can tolerate extensively heated egg. We investigated whether individual relative responses could differentiate children who tolerate baked egg. Read More

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November 2018
1 Read

Gene expression in the phenotypically plastic Arctic charr (Salvelinus alpinus): A focus on growth and ossification at early stages of development.

Evol Dev 2018 Nov 26. Epub 2018 Nov 26.

Department of Aquaculture and Fish Biology, Hólar University College, Háskólinn á Hólum, Sauðárkrókur, Iceland.

Gene expression during development shapes the phenotypes of individuals. Although embryonic gene expression can have lasting effects on developmental trajectories, few studies consider the role of maternal effects, such as egg size, on gene expression. Using qPCR, we characterize relative expression of 14 growth and/or skeletal promoting genes across embryonic development in Arctic charr (Salvelinus alpinus). Read More

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November 2018

P NMR assessment of the phosvitin-iron complex in mayonnaise.

Magn Reson Chem 2018 Nov 25. Epub 2018 Nov 25.

Unilever R&D Vlaardingen, Olivier van Noortlaan 120, 3133 AT, Vlaardingen, The Netherlands.

Lipid oxidation is the main reason for the limited shelf-life of mayonnaise. One of the main catalysts of this process is iron, which is introduced in its ferric (Fe (III)) form via phosvitin, an egg yolk phosphoprotein rich in phosphoserines. The binding of Fe (III) to phosvitin and its ability to establish a redox couple with Fe (II) is believed to determine the oxidation rate of unsaturated lipids. Read More

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November 2018
2 Reads

Toxicity effects of the organic UV-filter 4-Methylbenzylidene camphor in zebrafish embryos.

Chemosphere 2018 Nov 15;218:273-281. Epub 2018 Nov 15.

Department of Biology & CESAM, University of Aveiro, 3810-193, Aveiro, Portugal.

Ultraviolet (UV) filters are widely used in personal care products and due to their lipophilicity these chemicals tend to bioaccumulate in the aquatic biota. 4-Methylbenzylidene camphor (4-MBC) is one of the most used UV-filters, and it is commonly detected in freshwater fish tissues. This substance is suspected to be an endocrine disruptor due to its interaction with Hypothalamus-Pituitary-Gonadal (HPG) and HP-Thyroid (HPT)-axis. Read More

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November 2018
4 Reads

MicroRNA let-7 and miR-278 regulate insect metamorphosis and oogenesis via targeting juvenile hormone early response gene .

Development 2018 Nov 23. Epub 2018 Nov 23.

Key Laboratory of Plant Stress Biology, State Key Laboratory of Cotton Biology, School of Life Sciences, Henan University, Kaifeng 475004, China

Krüppel-homolog 1 (Kr-h1), a zinc finger transcription factor, transduces juvenile hormone (JH) signaling in inhibiting larval metamorphosis and promoting adult reproduction. While the transcriptional regulation of has been extensively studied, little is known about its regulation at the post-transcriptional level. By using the migratory locust, as a model system, we report here that microRNA let-7 and miR-278 bound to coding sequence and downregulated its expression. Read More

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November 2018
1 Read

Placental Macrophages: A Window Into Fetal Microglial Function in Maternal Obesity.

Int J Dev Neurosci 2018 Nov 20. Epub 2018 Nov 20.

Pediatrics and Program in Neuroscience, Harvard Medical School; Lurie Center for Autism, MassGeneral Hospital for Children. Electronic address:

Fetal placental macrophages and microglia (resident brain macrophages) have a common origin in the fetal yolk sac. Yolk-sac-derived macrophages comprise the permanent pool of brain microglia throughout an individual's lifetime. Inappropriate fetal microglial priming may therefore have lifelong neurodevelopmental consequences, but direct evaluation of microglial function in a living fetus or neonate is impossible. Read More

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November 2018
4 Reads

Is fertility sparing surgery a treatment option for young patients with yolk sac tumor?

Minerva Ginecol 2018 Dec;70(6):750-753

First Department of Surgery, General Hospital of Attica "KAT", Athens, Greece -

Yolk sac tumor (YST) is the third most frequent ovarian germ cell type ovarian tumor. YST occurs primarily in young girls and in women at reproductive age and thus, the preservation of fertility is considered to be a crucial option if possible for these patients. Compared to previous years, the use of innovative chemotherapeutic regimens in the treatment of YSTs improved significantly the prognosis and outcomes of this rare type of neoplasia. Read More

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December 2018
4 Reads

Osteoblasts Regulate Angiogenesis in Response to Mechanical Unloading.

Calcif Tissue Int 2018 Nov 21. Epub 2018 Nov 21.

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, via Vetoio - Coppito 2, 67100, L'aquila, Italy.

During mechanical unloading, endothelial cells reduce osteogenesis and increase bone resorption. Here we describe the feedback response of endothelial cells to unloaded osteoblasts. Primary endothelial cells, ex vivo mouse aortic rings and chicken egg yolk membranes were incubated with conditioned medium from mouse primary osteoblasts (OB-CM) subjected to unit gravity or simulated microgravity, to assess its effect on angiogenesis. Read More

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November 2018
11 Reads

In silico assessment and structural characterization of antioxidant peptides from major yolk protein of sea urchin Strongylocentrotus nudus.

Food Funct 2018 Nov 21. Epub 2018 Nov 21.

School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, P. R. China. and National Engineering Research Center of Seafood, Dalian 116034, P. R. China.

Sea urchin gonads have been demonstrated to contain major yolk protein (MYP), which can be hydrolyzed by enzymes to release biologically active peptides. The in silico analysis of the MYP sequence in the BIOPEP database showed the presence of fragments with antioxidant activity. The sequence was hydrolyzed by 21 kinds of proteases and 23 antioxidant peptides were obtained. Read More

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November 2018

Knockdown of calcium-binding calb2a and calb2b genes indicates the key regulator of the early development of the zebrafish, Danio rerio.

Brain Struct Funct 2018 Nov 20. Epub 2018 Nov 20.

Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli", 81100, Caserta, Italy.

The present study initiates our investigation regarding the role of calb2a and calb2b genes that are expressed in the central nervous system, including the multiple tissues during early embryonic development of zebrafish. In this study, we have adopted individual and combined morpholino-mediated inactivation approach to investigate the functions of calb2a and calb2b in early development of the zebrafish. We have found that calb2a and calb2b morpholino alone failed to generate an obvious phenotype; however, morphological inspection in early developmental stages of calb2a and calb2b combined knockdown morphants show abnormal neural plate folding in midbrain-hindbrain region. Read More

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November 2018

Carcinogenesis: the cancer cell-mast cell connection.

Inflamm Res 2018 Nov 20. Epub 2018 Nov 20.

Department of Surgery, School of Medicine, Complutense University of Madrid, Plaza de Ramón y Cajal s.n., 28040, Madrid, Spain.

Background: In mammals, inflammation is required for wound repair and tumorigenesis. However, the events that lead to inflammation, particularly in non-healing wounds and cancer, are only partly understood.

Findings: Mast cells, due to their great plasticity, could orchestrate the inflammatory responses inducing the expression of extraembryonic programs of normal and pathological tissue formation. Read More

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November 2018
4 Reads

Xiaoaiping Induces Developmental Toxicity in Zebrafish Embryos Through Activation of ER Stress, Apoptosis and the Wnt Pathway.

Front Pharmacol 2018 6;9:1250. Epub 2018 Nov 6.

School of Pharmaceutical Science, Shanxi Medical University, Taiyuan, China.

The aim of the study was to determine the developmental toxicity of the traditional Chinese medicine Xiaoaiping (XAP) and to investigate its underlying mechanism of action. Zebrafish embryos were incubated with 0.4, 0. Read More

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November 2018
3 Reads

Tailoring porous carbon spheres for supercapacitors.

Nanoscale 2018 Nov;10(46):21604-21616

State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, P. R. China.

The last decade has witnessed significant breakthroughs in the synthesis of porous carbon spheres (PCSs). This Review provides an updated summarization on the controlled synthesis of PCSs for supercapacitors. The synthetic methodologies can be generally categorized into (i) hard templating, (ii) soft templating, (iii) the modified Stöber method, (iv) hydrothermal carbonization (HTC), and (v) aerosol-assisted methods. Read More

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November 2018
2 Reads

Characterization and toxicology evaluation of zirconium oxide nanoparticles on the embryonic development of zebrafish, Danio rerio.

Drug Chem Toxicol 2018 Nov 20:1-8. Epub 2018 Nov 20.

d Department of Pharmacology , Saveetha Dental College and Hospitals, SIMATS , Chennai , TN , India.

Zirconia oxide nanoparticles (ZrONPs) are known to be one of the neutral bioceramic metal compounds that has been widely used for their beneficial applications in many biomedical areas, in dental implants, bone joint replacements, drug delivery vehicles, and in various industrial applications. To study the effects of ZrONPs on zebrafish model, we used early life stages of the zebrafish (Danio rerio) to examine such effects on embryonic development in this species. ZrONPs were synthesized by the sol-gel method, size about 15-20 nm and characterized by SEM, EDX, XRD, FTIR, UV-Vis Spectra. Read More

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November 2018
5 Reads

Semi-Quantification of Total and During Egg Incubations Using a Combination of 16S rDNA and Specific Pathogen Primers for qPCR.

Front Microbiol 2018 2;9:2454. Epub 2018 Nov 2.

Department of Food Science, University of Arkansas, Fayetteville, AR, United States.

Rapid molecular techniques that evaluate eggs for the presence of foodborne pathogens is an essential component to poultry food safety monitoring. Interestingly, it is not just table eggs that contribute to outbreaks of foodborne disease. Broiler layer production actively contributes to sustaining of foodborne pathogens within a flock. Read More

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November 2018
2 Reads

Facile Solvothermal Synthesis of CuCo₂S₄ Yolk-Shells and Their Visible-Light-Driven Photocatalytic Properties.

Materials (Basel) 2018 Nov 16;11(11). Epub 2018 Nov 16.

Department of Chemistry, National Institute of Technology, Silchar, Assam 788010, India.

In this present work, we synthesized a yolk-shell shaped CuCo₂S₄ by a simple anion exchange method. The morphological and structural properties of the as-synthesized sample were characterized using X-ray diffraction (XRD), UV-vis diffuse reflectance spectra (UV-vis DRS), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The SEM and TEM results confirmed that the uniform yolk-shell structure was formed during the solvothermal process. Read More

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November 2018

Disulphide Bridges in Surfactant Protein B Analogues Affect Their Activity in Synthetic Surfactant Preparations.

Neonatology 2018 Nov 19;115(2):134-141. Epub 2018 Nov 19.

Department of Molecular Medicine and Surgery, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden.

Background: Limited supply and complicated manufacturing procedure of animal-derived surfactants make the development of synthetic surfactants warranted. The synthesis of surfactant protein (SP)-B and SP-C is complicated and several analogues have been developed. Mini-BLeu is an analogue that corresponds to the first and last helix of SP-B joined by a loop and linked by 2 disulphide bridges. Read More

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November 2018
3 Reads

Effects of supplementation with different rapeseed oil sources and levels on production performance, egg quality, and serum parameters in laying hens.

Poult Sci 2018 Nov 18. Epub 2018 Nov 18.

Animal Nutrition Institute, Sichuan Agricultural University, Key Laboratory for Animal Disease-Resistance Nutrition of China, Ministry of Education, Chengdu 611130, China.

This study was to determine the effects of rapeseed oil on production performance, egg quality, and serum parameters in laying hens. A total of 1,080 hens (33-wk-old) were randomly divided into a 1 plus 4 × 2 factorial design including four different rapeseed oil sources [high erucic acid of Mianyang city (MH); high erucic acid of Deyang city (DH); low erucic acid of Mianyang (ML); low erucic acid of Deyang (DL)] at two levels (2% and 4%) for 12 wk. The egg production and egg weight were decreased (P < 0. Read More

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November 2018
3 Reads

Freezability and fertility of frozen-thawed boar semen supplemented with ostrich egg yolk lipoproteins.

Pol J Vet Sci 2018 Jun;21(2):255-263

Department of Pig Breeding, Faculty of Animal Bioengineering, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland.

Lipoproteins, isolated from ostrich egg yolk (LPFo), provide excellent protection for boar spermatozoa against cryo-induced damage. The present study was performed to investigate the effects of LPFo on the freezability and fertilizing capacity of frozen-thawed (FT) boar semen after post-cervical artificial inseminations (post-CAIs). Semen, collected from 7 Polish Large White (PLW) and 4 Polish Landrace (PLR), was frozen in an extender containing LPFo. Read More

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June 2018
2 Reads

Egg yolk immunoglobulins supplementation prevents rat liver from aflatoxin B1-induced oxidative damage and genotoxicity.

J Agric Food Chem 2018 Nov 17. Epub 2018 Nov 17.

Egg yolk immunoglobulins (IgY), as nutraceutical supplement for therapeutic or prophylactic intervention, has been extensively studied. The effects of IgY on small molecular toxin-induced toxicity in animals is unclear. In the present study, the protection of highly purified and specific anti-AFB1 IgY against AFB1-induced genotoxicity and oxidative damage on the rat liver model were investigated. Read More

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November 2018
3 Reads

Ovarian germinal epithelium, oocyte development and the secretory epithelium in monkfish (Lophius americanus Valenciennes).

J Morphol 2018 Nov 15. Epub 2018 Nov 15.

Florida Fish and Wildlife Conservation Commission, Florida Fish and Wildlife Research Institute, St. Petersburg, Florida.

Histological examination of ovarian morphology was conducted on the monkfish, Lophius americanus. The ovary is of the cystovarian type, that is, with a lumen. However, ovarian morphology is quite unique, compared to other fishes, in that ovarian lamellae only originate along the ventral ovarian wall rather than around the periphery. Read More

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November 2018