7,998 results match your criteria Yellow Fever

Recombinant vesicular stomatitis vaccine against nipah virus has a favorable safety profile: Model for assessment of live vaccines with neurotropic potential.

PLoS Pathog 2022 Jun 27;18(6):e1010658. Epub 2022 Jun 27.

Public Health Vaccines LLC, Cambridge, Massachusetts, United States of America.

Nipah virus (NiV) disease is a bat-borne zoonosis responsible for outbreaks with high lethality and is a priority for vaccine development. With funding from the Coalition of Epidemic Preparedness Innovations (CEPI), we are developing a chimeric vaccine (PHV02) composed of recombinant vesicular stomatitis virus (VSV) expressing the envelope glycoproteins of both Ebola virus (EBOV) and NiV. The EBOV glycoprotein (GP) mediates fusion and viral entry and the NiV attachment glycoprotein (G) is a ligand for cell receptors, and stimulates neutralizing antibody, the putative mediator of protection against NiV. Read More

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COVID-19 Vaccine: A Possible Trigger for Pyoderma Gangrenosum.

Cureus 2022 May 24;14(5):e25295. Epub 2022 May 24.

Nephrology, Faculty of Medicine, Hashemite University, Zarqa, JOR.

Pyoderma gangrenosum is an uncommon ulcerative auto-inflammatory dermatosis. Numerous studies suggest cutaneous side effects of the COVID-19 vaccine. Pyoderma gangrenosum has been reported as one of the rare side effects of the COVID-19 vaccine. Read More

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A recent chikungunya outbreak associated with the occurrence of Aedes vectors (Diptera: Culicidae) in Kassala state, eastern Sudan in 2018.

Parasitol Int 2022 Jun 22;90:102613. Epub 2022 Jun 22.

Entomology Department, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt.

Aedes aegypti and Ae. albopictus (Diptera: Culicidae) are primary vectors of human arboviral diseases such as dengue, chikungunya, yellow fever, and Zika viruses. Aedes aegypti is well distributed in Sudan, except in Northern and Khartoum states, while Ae. Read More

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Evaluation of Zika rapid tests as aids for clinical diagnosis and epidemic preparedness.

EClinicalMedicine 2022 Jul 4;49:101478. Epub 2022 Jun 4.

Clinical Research Department, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.

Background: Development and evaluation of diagnostics for diseases of epidemic potential are often funded during epidemics, but not afterwards, leaving countries unprepared for the next epidemic. United Nations Children's Emergency Fund (UNICEF) partnered with the United States Agency for International Development (USAID) to address this important gap by investing in an advance purchase commitment (APC) mechanism to accelerate the development and evaluation of Zika rapid diagnostic tests (RDTs) for case detection and surveillance. This paper describes the performance evaluation of five Zika RDTs eligible for procurement. Read More

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Mosquito-Borne Flaviviruses and Current Therapeutic Advances.

Viruses 2022 Jun 5;14(6). Epub 2022 Jun 5.

Department of Microbiology, Faculty of Naval Medicine, Naval Medical University, Shanghai 200433, China.

Mosquito-borne flavivirus infections affect approximately 400 million people worldwide each year and are global threats to public health. The common diseases caused by such flaviviruses include West Nile, yellow fever, dengue, Zika infection and Japanese encephalitis, which may result in severe symptoms and disorders of multiple organs or even fatal outcomes. Till now, no specific antiviral agents are commercially available for the treatment of the diseases. Read More

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Cross-Reactive Immunity among Five Medically Important Mosquito-Borne Flaviviruses Related to Human Diseases.

Viruses 2022 Jun 2;14(6). Epub 2022 Jun 2.

Department of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.

Flaviviruses cause a spectrum of potentially severe diseases. Most flaviviruses are transmitted by mosquitoes or ticks and are widely distributed all over the world. Among them, several mosquito-borne flaviviruses are co-epidemic, and the similarity of their antigenicity creates abundant cross-reactive immune responses which complicate their prevention and control. Read More

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Factors Involved in the Apoptotic Cell Death Mechanism in Yellow Fever Hepatitis.

Viruses 2022 Jun 1;14(6). Epub 2022 Jun 1.

Department of Pathology, State University of Para, Belem 66050-540, Brazil.

Yellow fever (YF), a non-contagious infectious disease, is endemic or enzootic to the tropical regions of the Americas and Africa. Periodic outbreaks or epidemics have a significant impact on public health. Programmed cell death, or apoptosis, is generally characterised by distinct morphological changes and energy-dependent biochemical pathways. Read More

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Genetic Diversity among Four Populations of (Diptera: Culicidae) from Honduras as Revealed by Mitochondrial DNA Cytochrome Oxidase I.

Pathogens 2022 May 26;11(6). Epub 2022 May 26.

Microbiology Research Institute, Universidad Nacional Autónoma de Honduras, Tegucigalpa 11101, Honduras.

is a hematophagous and highly anthropophilic mosquito with a wide distribution, particularly in tropical and subtropical regions of the world. is the main vector of several febrile diseases called arboviruses (dengue, yellow fever, chikungunya, and zika viruses), which represent an important public health problem. Populations of this mosquito were nearly eliminated from the Americas in the mid-20th century; however, after the abandonment of control measures, mosquito populations have been recovering territory, have expanded by anthropogenic mechanisms, and have been joined by new populations reintroduced from other continents. Read More

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Flavivirus NS1 Triggers Tissue-Specific Disassembly of Intercellular Junctions Leading to Barrier Dysfunction and Vascular Leak in a GSK-3β-Dependent Manner.

Pathogens 2022 May 24;11(6). Epub 2022 May 24.

Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, CA 94720-3370, USA.

The flavivirus nonstructural protein 1 (NS1) is secreted from infected cells and contributes to endothelial barrier dysfunction and vascular leak in a tissue-dependent manner. This phenomenon occurs in part via disruption of the endothelial glycocalyx layer (EGL) lining the endothelium. Additionally, we and others have shown that soluble DENV NS1 induces disassembly of intercellular junctions (IJCs), a group of cellular proteins critical for maintaining endothelial homeostasis and regulating vascular permeability; however, the specific mechanisms by which NS1 mediates IJC disruption remain unclear. Read More

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Interaction of (Diptera: Culicidae) and Other Mosquito Vectors in a Forested Area, Rio de Janeiro, Brazil.

Trop Med Infect Dis 2022 Jun 8;7(6). Epub 2022 Jun 8.

Diptera Laboratory, Oswaldo Cruz Institute (FIOCRUZ), Av. Brazil 4365, Manguinhos, Rio de Janeiro 21040-360, Brazil.

The yellow fever (YF) virus has been detected throughout Brazil, with the occurrence of human cases, cyclic epizootics, and its isolation from and . We assessed the seasonal occurrence, egg abundancy, and oviposition interaction of mosquito vector species captured at a Private Natural Heritage Reserve in the Atlantic Forest biome. A total of 2943 eggs and 1538 mosquito larvae were collected from which 1231 belonged to entomologically important species. Read More

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Parentage Assignment Using Microsatellites Reveals Multiple Mating in Aedes aegypti (Diptera: Culicidae): Implications for Mating Dynamics.

J Med Entomol 2022 Jun 23. Epub 2022 Jun 23.

Household & Structural Urban Entomology Laboratory, Vector Control Research Unit, School of Biological Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia.

The mosquito Aedes aegypti is the primary vector of the dengue, yellow fever, and chikungunya viruses. Evidence shows that Ae. aegypti males are polyandrous whereas Ae. Read More

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Bacterial diversity in Haemagogus leucocelaenus (Diptera: Culicidae) from Vale do Ribeira, São Paulo, Brazil.

BMC Microbiol 2022 Jun 22;22(1):161. Epub 2022 Jun 22.

Departamento de Epidemiologia, Faculdade de Saúde Pública, Universidade de São Paulo, Av. Dr. Arnaldo 715, São Paulo, SP, 01246-904, Brazil.

Introduction: Mosquitoes (Diptera: Culicidae) are vectors that transmit numerous pathogens to humans and other vertebrates. Haemagogus leucocelaenus is a mosquito associated with transmission of yellow fever virus. The insect gut harbors a variety of microorganisms that can live and multiply within it, thus contributing to digestion, nutrition, and development of its host. Read More

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The second coming of urban yellow fever in the Americas: looking the past to see the future.

An Acad Bras Cienc 2022 17;94(2):e20201252. Epub 2022 Jun 17.

Centro para el Desarrollo de la Investigación Científica (CEDIC), Manduvira, 635 e/15 de Agosto y O` Leary, PC1255, Asunción, Paraguay.

Yellow fever (YF) epizootics in South America during the 21st century have an unprecedented recorded magnitude and geographical dispersion. The YF spread progressively involved areas considered previously free of risk reaching the edge of cities with large unvaccinated populations, and urban outbreaks were frequently forecasted. We critically reviewed the initial stages and enhancing contexts of YF urban epidemics since the 17th century in the Americas, and the modeling attempts of YF epidemic risk by of Aedes-Human transmission, to find common factors that increase the probability of these events in the current scenarios. Read More

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The production of health news by the press: the context of the coverage of the 2007/2008 yellow fever epidemic.

Cien Saude Colet 2022 Jul 18;27(7):2817-2825. Epub 2022 Feb 18.

Faculdade de Saúde Pública, USP. São Paulo SP Brasil.

The COVID-19 pandemic scenario raises the amplification of the debate around the production and circulation of information about epidemics. In this sense, the objective of this article is to discuss how social contexts shape the news, taking as an example the case of the news coverage that transformed an epizootic of yellow fever, in the summer of 2007/2008, into an epidemic of urban yellow fever. This is a qualitative research with journalists who worked in two large circulation newspapers and actively participated in the coverage of the event. Read More

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Previous biological therapy and impairment of the IFN-γ/IL-10 axis are associated with low immune response to 17DD-YF vaccination in patients with spondyloarthritis.

Vaccine 2022 Jun 18. Epub 2022 Jun 18.

Hospital Universitário Cassiano Antônio Moraes, Universidade Federal do Espírito Santo (UFES), Vitória, ES, Brazil; Programa de Pós-graduação em Saúde Coletiva da Universidade Federal do Espírito Santo (UFES), Vitória, ES, Brazil. Electronic address:

Yellow fever (YF) vaccination is known to induce a suboptimal response in patients with autoimmune diseases (AIDs). To date, few studies have focused on the performance of 17DD-YF vaccination in patients with spondyloarthritis (SpA). In general, patients with SpA are young and have less comorbidities than other patients with AIDs, and frequently receive biological disease-modifying antirheumatic drugs (DMARDs) that may impact their response to vaccines. Read More

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Plants extracts from Cameroon pharmacopeia strongly inhibit the Chikungunya virus infection by targeting entry and replication steps.

J Ethnopharmacol 2022 Jun 18;296:115458. Epub 2022 Jun 18.

Infectious Disease Biology, Institute of Life Sciences, Nalco Square, Chandrasekharpur, 751023, Bhubaneswar, Odisha, India. Electronic address:

Ethnopharmacological Relevance: Cameroon is one of the sub-Saharan African countries affected by Chikungunya virus (CHIKV). With the absence of approved treatment, this disease represents globally a major public health concern. Several plants are traditionally used in Cameroon for the treatment of virus induced fever and arthralgia. Read More

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Review of the ecology and behaviour of and in Western Africa and implications for vector control.

Curr Res Parasitol Vector Borne Dis 2022 ;2:100074

Department of Vector Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK.

Western Africa is vulnerable to arboviral disease transmission, having recently experienced major outbreaks of chikungunya, dengue, yellow fever and Zika. However, there have been relatively few studies on the natural history of the two major human arbovirus vectors in this region, and , potentially limiting the implementation of effective vector control. We systematically searched for and reviewed relevant studies on the behaviour and ecology of and in Western Africa, published over the last 40 years. Read More

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January 2022

Animal venoms as a source of antiviral peptides active against arboviruses: a systematic review.

Arch Virol 2022 Jun 20. Epub 2022 Jun 20.

Laboratório de Microbiologia Médica, Laboratório de Diagnóstico Laboratorial e Microbiologia Clínica, Campus Centro Oeste Dona Lindu, Universidade Federal de São João Del-Rei (UFSJ-CCO), Rua Sebastião Gonçalves Coelho, 400, Divinópolis, Minas Gerais, 35501-293, Brazil.

Arthropod-borne viruses (arboviruses), such as Zika virus (ZIKV), chikungunya virus (CHIKV), dengue virus (DENV), yellow fever virus (YFV), and West Nile virus (WNV), are pathogens of global importance. Therefore, there has been an increasing need for new drugs for the treatment of these viral infections. In this context, antimicrobial peptides (AMPs) obtained from animal venoms stand out as promising compounds because they exhibit strong antiviral activity against emerging arboviral pathogens. Read More

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Adenovirus vector-based vaccines as forefront approaches in fighting the battle against flaviviruses.

Hum Vaccin Immunother 2022 Jun 17:2079323. Epub 2022 Jun 17.

Department of Molecular Virology, Pasteur Institute of Iran, Tehran, Iran.

Flaviviruses are arthropod-borne viruses (arboviruses) that have been recently considered among the significant public health problems in defined geographical regions. In this line, there have been vaccines approved for some flaviviruses including dengue virus (DENV), Japanese encephalitis virus (JEV), yellow fever virus (YFV), and tick-borne encephalitis virus (TBEV), although the efficiency of such vaccines thought to be questionable. Surprisingly, there are no effective vaccine for many other hazardous flaviviruses, including West Nile and Zika viruses. Read More

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Th22 cytokines and yellow fever: Possible implications for the immunopathogenesis of human liver infection.

Cytokine 2022 Jun 12;157:155924. Epub 2022 Jun 12.

Instituto Evandro Chagas, Ministério da Saúde, Ananindeua, PA, Brazil; Universidade Federal do Pará, Belém, PA, Brazil; Universidade de São Paulo, São Paulo, SP, Brazil. Electronic address:

Yellow fever (YF) is an infectious disease considered a public health problem in tropical and subtropical areas. YF has many pathophysiological events that are correlated with the host immune response. In this study, the in situ Th22 cytokine profile was evaluated. Read More

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Evaluation of Whatman FTA cards for the preservation of yellow fever virus RNA for use in molecular diagnostics.

PLoS Negl Trop Dis 2022 06 15;16(6):e0010487. Epub 2022 Jun 15.

Centers for Disease Control and Prevention, Division of Vector-Borne Diseases, Fort Collins, Colorado, United States of America.

Yellow fever virus (YFV) is a flavivirus that frequently causes outbreaks of hemorrhagic fever in Africa and South America and is considered a reemerging public health threat. Accurate diagnosis of yellow fever (YF) disease is critical as one confirmed case constitutes an outbreak and may trigger a mass vaccination campaign. Highly sensitive and specific molecular diagnostics have been developed; however, these assays require maintenance of cold-chain during transport of specimens to prevent the degradation of viral RNA prior to testing. Read More

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A Brief History of Human Challenge Studies (1900-2021) Emphasising the Virology, Regulatory and Ethical Requirements, Raison D'etre, Ethnography, Selection of Volunteers and Unit Design.

Curr Top Microbiol Immunol 2022 Jun 16. Epub 2022 Jun 16.

Wellcome Trust, 215 Euston Road, London, NW1 2BE, UK.

Venetian quarantine 400 years ago was an important public health measure. Since 1900 this has been refined to include "challenge" or deliberate infection with pathogens be they viruses, bacteria, or parasites. Our focus is virology and ranges from the early experiments in Cuba with Yellow Fever Virus to the most widespread pathogen of our current times, COVID-19. Read More

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The scientific publication of the Memórias do Instituto Oswaldo Cruz (1909-2020): a history of contribution to the biomedical sciences.

Mem Inst Oswaldo Cruz 2022 13;117:e210376. Epub 2022 Jun 13.

Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Comunicação Celular, Rio de Janeiro, RJ, Brasil.

Background: The Memórias do Instituto Oswaldo Cruz (MIOC) is one of the first scientific journals created in Brazil and currently one of the most important biomedical journals in South America. Knowledge of the main themes disseminated over time and its main contributors can contribute towards a better understanding of its trajectory and future.

Objectives: Map the journal's scientific publication between 1909 and 2020. Read More

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Yellow fever vaccination before and during the covid-19 pandemic in Brazil.

Rev Saude Publica 2022 13;56:45. Epub 2022 Jun 13.

Universidade Federal de Minas Gerais. Escola de Enfermagem. Departamento de Enfermagem Materno-Infantil e Saúde Pública. Belo Horizonte, MG, Brasil.

Objective: To analyze the number of yellow fever vaccine doses administered before and during the covid-19 pandemic in Brazil.

Methods: This is an ecological, time series study based on data from the National Immunization Program. Differences between the median number of yellow fever vaccine doses administered in Brazil and in its regions before (from April/2019 to March/2020) and after (from April/2020 to March/2021) the implementation of social distancing measures in the country were assessed via the Mann-Whitney test. Read More

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Broad-spectrum anti-flavivirus activity and chemistry of compounds containing sulfur and oxygen chalcogens.

Curr Med Chem 2022 Jun 10. Epub 2022 Jun 10.

Department of Pharmaceutical Sciences, Università degli Studi di Perugia, via del Liceo, 1-06123 Perugia, Italy.

Sulfur and oxygen containing-compounds are a relevant class of derivatives that is constantly growing due to their wide range of pharmacological activity, including the antiviral one. As a proof of this, there are several FDA approved antiviral compounds having sulfur and oxygen in their structures. Among RNA viruses, the flavivirus genus (e. Read More

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Essential functions of mosquito ecdysone importers in development and reproduction.

Proc Natl Acad Sci U S A 2022 Jun 13;119(25):e2202932119. Epub 2022 Jun 13.

Department of Entomology, Institute for Integrative Genome Biology, University of California, Riverside, CA 92521.

The primary insect steroid hormone ecdysone requires a membrane transporter to enter its target cells. Although an organic anion-transporting polypeptide (OATP) named Ecdysone Importer (EcI) serves this role in the fruit fly and most likely in other arthropod species, this highly conserved transporter is apparently missing in mosquitoes. Here we report three additional OATPs that facilitate cellular incorporation of ecdysone in and the yellow fever mosquito . Read More

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Risk factors associated with non-vaccination in Gambian children: a population-based cohort study.

Trans R Soc Trop Med Hyg 2022 Jun 13. Epub 2022 Jun 13.

MRC Unit The Gambia at LSHTM, Fajara, 00000, The Gambia.

Background: We determined the risk factors associated with unvaccinated children in rural Gambia.

Methods: We conducted prospective demographic surveillance and recorded immunisations in real time in the Upper River Region, The Gambia. Analysis included residents born from 1 January 2012 to 31 December 2016. Read More

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Functional analysis reveals ionotropic GABA receptor subunit RDL, is a target site of ivermectin and fluralaner in the yellow fever mosquito, Aedes aegypti.

Pest Manag Sci 2022 Jun 12. Epub 2022 Jun 12.

Laboratory of Tropical Veterinary Medicine and Vector Biology, School of Life Sciences, Hainan University, Haikou, Hainan, 570228, People's Republic of China.

Background: Ionotropic γ-aminobutyric acid (iGABA) receptors are involved in various physiological activities in insects, including sleep, olfactory memory, movement, and resistance to viruses. Ivermectin and fluralaner can disturb the insect nervous system by binding to iGABA receptors, and are therefore an effective means for controlling insect pests. However, the molecular mechanisms underlying the insecticidal effect of both the compounds on Aedes. Read More

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Vector-Borne Viral Diseases as a Current Threat for Human and Animal Health-One Health Perspective.

J Clin Med 2022 May 27;11(11). Epub 2022 May 27.

Department of Virology, National Veterinary Research Institute, Al. Partyzantow 57, 24-100 Pulawy, Poland.

Over the last decades, an increase in the emergence or re-emergence of arthropod-borne viruses has been observed in many regions. Viruses such as dengue, yellow fever, or zika are a threat for millions of people on different continents. On the other hand, some arboviruses are still described as endemic, however, they could become more important in the near future. Read More

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Lipases secreted by a gut bacterium inhibit arbovirus transmission in mosquitoes.

PLoS Pathog 2022 06 9;18(6):e1010552. Epub 2022 Jun 9.

Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University, Beijing, China.

Arboviruses are etiological agents of various severe human diseases that place a tremendous burden on global public health and the economy; compounding this issue is the fact that effective prophylactics and therapeutics are lacking for most arboviruses. Herein, we identified 2 bacterial lipases secreted by a Chromobacterium bacterium isolated from Aedes aegypti midgut, Chromobacterium antiviral effector-1 (CbAE-1) and CbAE-2, with broad-spectrum virucidal activity against mosquito-borne viruses, such as dengue virus (DENV), Zika virus (ZIKV), Japanese encephalitis virus (JEV), yellow fever virus (YFV) and Sindbis virus (SINV). The CbAEs potently blocked viral infection in the extracellular milieu through their lipase activity. Read More

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