6,683 results match your criteria Yellow Fever


2018 in review: five hot topics in tropical medicine.

Trop Dis Travel Med Vaccines 2019 15;5. Epub 2019 Apr 15.

2Tropical Disease Unit, Toronto General Hospital, 200 Elizabeth Street, 13EN-218, Toronto, ON M5G 2C4 Canada.

The year 2018 heralded many new developments in the field of tropical medicine, including licensure of novel drugs for novel indications, licensure of existing drugs for existing indications but in novel settings, and globalized outbreaks of both vector-borne and zoonotic diseases. We herein describe five top stories in tropical medicine that occurred during 2018, and illuminate the practice-changing development within each story. Read More

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https://tdtmvjournal.biomedcentral.com/articles/10.1186/s407
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http://dx.doi.org/10.1186/s40794-019-0082-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466725PMC
April 2019
1 Read

Towards high quality real-time whole genome sequencing during outbreaks using Usutu virus as example.

Infect Genet Evol 2019 Apr 20. Epub 2019 Apr 20.

ErasmusMC, Department of Viroscience, WHO Collaborating Centre for Arbovirus and Viral Hemorrhagic Fever Reference and Research, Rotterdam, the Netherlands. Electronic address:

Recently, protocols for amplicon based whole genome sequencing using Nanopore technology have been described for Ebola virus, Zika virus, yellow fever virus and West Nile virus. However, there is some debate regarding reliability of sequencing using this technology, which is important for applications beyond diagnosis such as linking lineages to outbreaks, tracking transmission pathways and pockets of circulation, or mapping specific markers. To our knowledge, no in depth analyses of the required read coverage to compensate for the error profile in Nanopore sequencing have been described. Read More

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http://dx.doi.org/10.1016/j.meegid.2019.04.015DOI Listing

Knockdown resistance (kdr) mutations within seventeen field populations of Aedes albopictus from Beijing China: first report of a novel V1016G mutation and evolutionary origins of kdr haplotypes.

Parasit Vectors 2019 Apr 24;12(1):180. Epub 2019 Apr 24.

State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.

Background: Aedes albopictus (Skuse) is an important vector of chikungunya, dengue, yellow fever and Zika viruses. In the absence of anti-viral medication and with limited availability of a commercial vaccine for public health use, vector control remains an effective means for reducing Aedes-borne disease morbidity. Knowledge about genetic mutations associated with insecticide resistance (IR) is a prerequisite for developing rapid resistance diagnosis, and the distribution and frequency of IR conferring mutations is important information for making smart vector control decisions. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13071-019-3423-xDOI Listing
April 2019
1 Read

Eutrophication governs predator-prey interactions and temperature effects in Aedes aegypti populations.

Parasit Vectors 2019 Apr 24;12(1):179. Epub 2019 Apr 24.

Institute of Environmental Sciences, Leiden University, Leiden, The Netherlands.

Background: Mosquito population dynamics are driven by large-scale (e.g. climatological) and small-scale (e. Read More

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http://dx.doi.org/10.1186/s13071-019-3431-xDOI Listing

Uptake of Travel Health Services by Community Pharmacies and Patients Following Pharmacist Immunization Scope Expansion in Ontario, Canada.

Pharmacy (Basel) 2019 Apr 13;7(2). Epub 2019 Apr 13.

Ted Rogers School of Management, Ryerson University, Toronto, ON M5G 2C3, Canada.

In December 2016, pharmacists in Ontario, Canada with authorization to administer injections saw an expansion in their scope from a restriction to the influenza vaccination only to now including an additional 13 vaccine-preventable diseases, largely those related to travel. It was uncertain whether this change in scope would see sufficient uptake, or translate to a corresponding expansion in other travel health service offerings from community pharmacies. In October/November 2017 a survey was conducted of all licensed community pharmacists in Ontario, followed by semi-structured interviews with 6 survey respondents in June 2018. Read More

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http://dx.doi.org/10.3390/pharmacy7020035DOI Listing

Four human diseases with significant public health impact caused by mosquito-borne flaviviruses: West Nile, Zika, dengue and yellow fever.

Semin Diagn Pathol 2019 Apr 17. Epub 2019 Apr 17.

Anatomic Pathology and Molecular Oncology, University of Utah, Salt Lake City, UT, United States.

In this review we will discuss the epidemiology, clinical characteristics, diagnostic tests, pathologic features, treatment and disease prevention strategies for four mosquito-borne flaviviruses. West Nile and Zika viruses, once thought to be restricted geographically, emerged on the American continent in the first part of the 21st century. They have been constantly in the lay press and have caused a heightened awareness of emerging infections by the public, particularly given the manifestation of microcephaly in congenital Zika syndrome. Read More

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http://dx.doi.org/10.1053/j.semdp.2019.04.009DOI Listing

Production and Biomedical Application of Flavivirus-like Particles.

Trends Biotechnol 2019 Apr 16. Epub 2019 Apr 16.

Department of Recombinant Vaccines, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Abrahama 58, 80-307 Gdansk, Poland. Electronic address:

Many viruses belonging to the Flaviviridae family are transmitted by invertebrate vectors. Among those transmitted by mosquitos, there are many human pathogens of great medical importance, such as Japanese encephalitis virus, West Nile virus, dengue virus, Zika virus, or yellow fever virus. Millions of people contract mosquito-borne diseases each year, leading to thousands of deaths. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01677799193007
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http://dx.doi.org/10.1016/j.tibtech.2019.03.013DOI Listing
April 2019
1 Read

Hierarchical Virtual Screening of Potential Insectides Inhibitors of Acetylcholinesterase and Juvenile Hormone from Temephos.

Pharmaceuticals (Basel) 2019 Apr 18;12(2). Epub 2019 Apr 18.

Postgraduate Program in-Network in Pharmaceutical Innovation, Federal University of Amapá, Macapá, AP 68902-280, Brazil.

(Linnaeus, 1762; Diptera: Culicidae) is the main vector transmitting viral diseases such as dengue fever, dengue haemorrhagic fever, urban yellow fever, zika and chikungunya. Worldwide, especially in the Americas and Brazil, many cases of dengue have been reported in recent years, which have shown significant growth. The main control strategy is the elimination of the vector, carried out through various education programs, to change human habits, but the most usual is biological control, together with environmental management and chemical control. Read More

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http://dx.doi.org/10.3390/ph12020061DOI Listing

Larvicidal activity of Ocimum campechianum, Ocotea quixos and Piper aduncum essential oils against Aedes aegypti.

Parasite 2019 17;26:23. Epub 2019 Apr 17.

Department of Infectious Diseases, National Institute of Health (Istituto Superiore di Sanità, ISS), V.le Regina Elena 299, 00161 Rome, Italy.

Aedes aegypti, the main arbovirus vector of the Yellow fever, Dengue, Chikungunya and Zika viruses, is widely distributed in tropical and subtropical areas throughout the world. Preventive control efforts have been implemented worldwide aimed at reducing its impact on human health. The recent reduction of chemicals available for vector control due to their negative impact on the environment and human health and the increase in mosquito resistance to insecticides have driven the research community to identify and evaluate sustainable alternatives to synthetic insecticides. Read More

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http://dx.doi.org/10.1051/parasite/2019024DOI Listing
April 2019
2 Reads

[Mufangji Decoction formula tracing and its effect on emergency and severe cases].

Authors:
Xing-Jiang Xiong

Zhongguo Zhong Yao Za Zhi 2019 Jan;44(2):388-400

Guang'anmen Hospital,China Academy of Chinese Medical Sciences Beijing 100053,China.

Mufangji Decoction is a famous herbal formula from Synopsis of Golden Chamber. However,it is easy to be misunderstood due to so its unique compatability. The syndromes treated by Mufangji Decoction included the following aspects:(1) in terms of modern medicine,it could be used to treat acute and chronic heart failure,heart failure aggravated by lung infection,chronic obstructive pulmonary disease acute episode,pulmonary heart disease,bilateral pleural effusion,acute attack of gout,rheumatic fever,rheumatoid arthritis,and rheumatoid arthritis;(2) in terms of symptoms,it could be used to treat asthma,chest tightness,wheeze impacting prostration and dyspnea impacting sitting posture; gastric distention; dark face,cyanotic,and mitral valvular face; edema of head and extremities; dry mouth,thirsty,unwilling to wear thick clothes,intolerance of heat,and irritable; fatigue,shortness of breath,poor appetite,constipation,less urine,yellow color,poor response to diuretics,and diuretic resistance; fast heart rate,which is hard to be controlled by Western medicine and has no response to Zhenwu Decoction; dark red tongue,dry tongue with yellow fur,rapid pulse,or deep tight pulse. Read More

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http://www.cnki.net/kcms/doi/10.19540/j.cnki.cjcmm.2019.0009
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http://dx.doi.org/10.19540/j.cnki.cjcmm.2019.0009DOI Listing
January 2019
2 Reads

Pathways Exploited by Flaviviruses to Counteract the Blood-Brain Barrier and Invade the Central Nervous System.

Front Microbiol 2019 28;10:525. Epub 2019 Mar 28.

Departamento de Virologia, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.

Human infection by different flaviviruses may cause severe neurologic syndromes, through pathogenic mechanisms that are still largely unknown. Japanese encephalitis virus (JEV), West Nile virus (WNV), Zika virus (ZIKV), yellow fever virus (YFV), dengue virus (DENV), and tick-borne encephalitis virus (TBEV) are believed to reach the central nervous system by a hematogenous route, upon crossing the blood-brain barrier. Although the disruption of BBB during flavivirus infection has been largely evidenced in experimental models, the relevance of BBB breakdown for virus entering the brain was not completely elucidated. Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2019.00525
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http://dx.doi.org/10.3389/fmicb.2019.00525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447710PMC
March 2019
2 Reads

Arboviral diseases and malaria in Australia, 2014–15: Annual report of the National Arbovirus and Malaria Advisory Committee

Commun Dis Intell (2018) 2019 Apr 15;43. Epub 2019 Apr 15.

Royal Darwin Hospital Northern Territory; Menzies School of Health Research, Darwin, Northern Territory

This report describes the epidemiology of mosquito-borne diseases of public health importance in Australia during the 2014–15 season (1 July 2014 to 30 June 2015) and includes data from human notifications, sentinel chicken, vector and virus surveillance programs. The National Notifiable Diseases Surveillance System received notifications for 12,849 cases of disease transmitted by mosquitoes during the 2014–15 season. The Australasian alphaviruses Barmah Forest virus and Ross River virus accounted for 83% (n=10,723) of notifications. Read More

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April 2019
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Immunogenicity of pneumococcal conjugate vaccine formulations containing pneumococcal proteins, and immunogenicity and reactogenicity of co-administered routine vaccines - A phase II, randomised, observer-blind study in Gambian infants.

Vaccine 2019 May 8;37(19):2586-2599. Epub 2019 Apr 8.

GSK, Wavre, Belgium. Electronic address:

Background: Two conserved pneumococcal proteins, pneumolysin toxoid (dPly) and pneumococcal histidine triad protein D (PhtD), combined with 10 polysaccharide conjugates from the pneumococcal non-typeable Haemophilus influenzae protein D-conjugate vaccine (PHiD-CV) in two investigational pneumococcal vaccine (PHiD-CV/dPly/PhtD) formulations were immunogenic and well-tolerated when administered to Gambian children. Here, we report immunogenicity of the polysaccharide conjugates, and immunogenicity and reactogenicity of co-administered routine vaccines.

Methods: In this phase II, controlled, observer-blind, single-centre study, healthy infants aged 8-10 weeks were randomised (1:1:1:1:1:1) to six groups. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X193035
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http://dx.doi.org/10.1016/j.vaccine.2019.03.033DOI Listing
May 2019
6 Reads

The Public Health Benefits and Economic Value of Routine Yellow Fever Vaccination in Colombia.

Value Health Reg Issues 2019 Apr 8;20:60-65. Epub 2019 Apr 8.

Clinical Epidemiology and Biostatistics Department, Pontificia Universidad Javeriana, Medical School, Bogotá, Colombia.

Objectives: To evaluate the public health benefits and economic value of live-attenuated yellow fever (YF) 17D vaccine in Colombia.

Methods: A decision tree model was used to assess the theoretical impact of routine YF vaccination of 1-year-olds (no "catch-up") during the interepidemic period from 1980 to 2002, avoiding capturing the impact of YF vaccine introduction in 2003. The vaccine was assumed to be 99% effective, to provide lifetime protection, and to cover 85% of the target population. Read More

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http://dx.doi.org/10.1016/j.vhri.2019.01.004DOI Listing
April 2019
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The Unfolded Protein Response: A Key Player in Zika Virus-Associated Congenital Microcephaly.

Front Cell Neurosci 2019 26;13:94. Epub 2019 Mar 26.

GIGA-Stem Cells, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R), University of Liège, Liège, Belgium.

Zika virus (ZIKV) is a mosquito-borne virus that belongs to the family, together with dengue, yellow fever, and West Nile viruses. In the wake of its emergence in the French Polynesia and in the Americas, ZIKV has been shown to cause congenital microcephaly. It is the first arbovirus which has been proven to be teratogenic and sexually transmissible. Read More

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http://dx.doi.org/10.3389/fncel.2019.00094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445045PMC
March 2019
1 Read

Dengue and Zika Virus 5' Untranslated Regions Harbor Internal Ribosomal Entry Site Functions.

MBio 2019 Apr 9;10(2). Epub 2019 Apr 9.

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA

The genus of the family encompasses numerous enveloped plus-strand RNA viruses. Dengue virus (DENV), a flavivirus, is the leading cause of serious arthropod-borne disease globally. The genomes of DENV, like the genomes of yellow fever virus (YFV), West Nile fever virus (WNV), or Zika virus (ZIKV), control their translation by a 5'-terminal capping group. Read More

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http://dx.doi.org/10.1128/mBio.00459-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456755PMC
April 2019
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Gamma Radiation Sterilization Dose of Adult Males in Asian Tiger Mosquito Pupae.

Insects 2019 Apr 8;10(4). Epub 2019 Apr 8.

Department of Irradiation Technology Center-CTR, University of São Paulo/Institute of Nuclear Energy Research-IPEN/USP, São Paulo SP 05508-000, Brazil.

The pathogen-carrying tiger mosquito, , has spread from the Western Pacific and Southeast Asia to Europe, Africa, the Middle East, North and South America, and the Caribbean. This species of mosquito transmits arboviral infections, such as yellow fever, chikungunya, dengue, zika, and several encephalitides. The objective of this research was to provide a radiation dose inducing sterilization in adult male in the pupal stage. Read More

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https://www.mdpi.com/2075-4450/10/4/101
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http://dx.doi.org/10.3390/insects10040101DOI Listing
April 2019
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Lack of Evidence of Sylvatic Transmission of Dengue Viruses in the Amazon Rainforest Near Iquitos, Peru.

Vector Borne Zoonotic Dis 2019 Apr 9. Epub 2019 Apr 9.

3 Department of Viral and Rickettsial Diseases, Naval Medical Research Center, Silver Spring, Maryland.

Dengue viruses (DENV) are currently responsible for more human morbidity and mortality than any other known arbovirus, and all four DENV are known to exist in sylvatic cycles that might allow these viruses to persist if the urban (Aedes aegypti) cycle could be controlled. To determine whether DENV were being maintained in a sylvatic cycle in a forested area about 14 km southwest of Iquitos, Peru, a city in which all 4 serotypes of DENV circulate, we placed 20 DENV seronegative Aotus monkeys in cages either in the canopy or near ground level for a total of 125.6 months. Read More

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https://www.liebertpub.com/doi/10.1089/vbz.2018.2408
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http://dx.doi.org/10.1089/vbz.2018.2408DOI Listing
April 2019
7 Reads

Green synthesis of copper oxide nanoparticles and mosquito larvicidal activity against dengue, zika and chikungunya causing vector .

IET Nanobiotechnol 2018 Dec;12(8):1042-1046

Department of Nanoscience and Technology, Tamilnadu Agricultural University, Coimbatore 641 003, India.

In the present study, high purity copper oxide nanoparticles (NPs) were synthesised using leaf extract. Green syntheses of nano-mosquitocides rely on plant compounds as reducing and stabilising agents. Copper oxide NPs were characterised using X-ray diffraction (XRD) analysis, Fourier transform infrared (FT-IR), Field-emission scanning electron microscopy with energy dispersive spectroscopy, Ultraviolet-visible spectrophotometry and fluorescence spectroscopy. Read More

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http://dx.doi.org/10.1049/iet-nbt.2018.5083DOI Listing
December 2018
2 Reads

Structural and mechanistic insight from antiviral and antiparasitic enzyme drug targets for tropical infectious diseases.

Curr Opin Struct Biol 2019 Apr 4;59:65-72. Epub 2019 Apr 4.

Institute of Physics of São Carlos, University of São Paulo, Av. Joao Dagnone, 1100 - Jardim Santa Angelina, São Carlos 13563-120, Brazil. Electronic address:

With almost half of the world population living at risk, tropical infectious diseases cause millions of deaths every year in developing countries. Considering the lack of economic prospects for investment in this field, approaches aiming the rational design of compounds, such as structure-based drug discovery (SBDD), fragment screening, target-based drug discovery, and drug repurposing are of special interest. Herein, we focused in the advances on the field of SBDD targeting arboviruses such as dengue, yellow fever, zika and chikungunya enzymes of the RNA replication complex (RC) and enzymes involved in a variety of pathways essential to ensure parasitic survival in the host, for malaria, Chagas e leishmaniasis diseases. Read More

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http://dx.doi.org/10.1016/j.sbi.2019.02.014DOI Listing
April 2019
1 Read

Keeping our immigrants healthy: hygienist doctrine in the Hospedaria de Imigrantes da Ilha das Flores.

Hist Cienc Saude Manguinhos 2019 Jan-Mar;26(1):15-32

Pesquisadora, Centro de Memória da Imigração da Ilha das Flores/Uerj. Rio de Janeiro - RJ - Brasil.

The Hospedaria de Imigrantes (Immigrant Lodgings) da Ilha das Flores was established in 1883 in accordance with the hygienist thinking of the time. Immigrants were isolated on the east coast of Guanabara Bay because of the epidemics of yellow fever which returned to the Imperial capital every summer since 1849-1850. Hygienists attributed the disease to the precarious health conditions in the city of Rio de Janeiro, which enabled germs to multiply and infect the atmosphere. Read More

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http://dx.doi.org/10.1590/S0104-59702019000100002DOI Listing
April 2017
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Detrimental Effects of Induced Antibodies on Aedes aegypti Reproduction.

Neotrop Entomol 2019 Apr 2. Epub 2019 Apr 2.

Depto de Biotecnología y Bioquímica, Centro de Investigación y de Estudios Avanzados del IPN, Irapuato, Gto., Mexico.

Aedes aegypti (Linnaeus) (Diptera: Culicidae) is the main vector of viruses causing dengue, chikungunya, Zika, and yellow fever, worldwide. This report focuses on immuno-blocking four critical proteins in the female mosquito when fed on blood containing antibodies against ferritin, transferrin, one amino acid transporter (NAAT1), and acetylcholinesterase (AchE). Peptides from these proteins were selected, synthetized, conjugated to carrier proteins, and used as antigens to immunize New Zealand rabbits. Read More

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http://link.springer.com/10.1007/s13744-019-00678-5
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http://dx.doi.org/10.1007/s13744-019-00678-5DOI Listing
April 2019
5 Reads

Correction to: Complete NMR chemical shift assignments of odorant binding protein 22 from the yellow fever mosquito, Aedes aegypti, bound to arachidonic acid.

Biomol NMR Assign 2019 Apr 2. Epub 2019 Apr 2.

Department of Pharmacology, University of Colorado School of Medicine, 12801 East 17th Ave, Aurora, CO, 80045, USA.

The article listed above was initially published with incorrect copyright information. Upon publication of this Correction, the copyright of the article is changed to "The Author(s)". The original article has been corrected. Read More

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http://dx.doi.org/10.1007/s12104-019-09891-0DOI Listing
April 2019
2 Reads

Epizootics due to Yellow Fever Virus in São Paulo State, Brazil: viral dissemination to new areas (2016-2017).

Sci Rep 2019 Apr 2;9(1):5474. Epub 2019 Apr 2.

Vector-Borne Diseases Group, Virology Center, Adolfo Lutz Institute, Sao Paulo, Brazil.

Beginning in late 2016 Brazil faced the worst outbreak of Yellow Fever in recent decades, mainly located in southeastern rural regions of the country. In the present study we characterize the Yellow Fever Virus (YFV) associated with this outbreak in São Paulo State, Brazil. Blood or tissues collected from 430 dead monkeys and 1030 pools containing a total of 5,518 mosquitoes were tested for YFV by quantitative RT-PCR, immunohistochemistry (IHC) and indirect immunofluorescence. Read More

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http://dx.doi.org/10.1038/s41598-019-41950-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445104PMC
April 2019
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Fractional-dose yellow fever vaccination: an expert review.

J Travel Med 2019 Apr 1. Epub 2019 Apr 1.

Department of Infectious Diseases, Leiden University Medical Center.

Rationale For Review: The global yellow fever vaccine supply is insufficient to provide full-dose vaccination to millions threatened by outbreaks. Given the excess of live-attenuated 17D yellow fever virus in the current single dose vials, dose-sparing would increase available vaccine doses manifold. Fractional-dose yellow fever vaccination is now accepted as an emergency solution, as short-term protection has been confirmed in an outbreak situation in the Democratic Republic of Congo, but broader application of this dose-sparing strategy is still not recommended. Read More

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https://academic.oup.com/jtm/advance-article/doi/10.1093/jtm
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http://dx.doi.org/10.1093/jtm/taz024DOI Listing
April 2019
10 Reads

Simultaneous detection of Dengue virus, Chikungunya virus, Zika virus, Yellow fever virus and West Nile virus.

J Virol Methods 2019 Jun 28;268:53-55. Epub 2019 Mar 28.

Servicio de Microbiología, Hospital Universitario Central de Asturias (HUCA) and Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.

Although certain mosquito-borne virus, such as Dengue virus (DENV), Chikungunya virus (CHIKV), Zika virus (ZIKV), Yellow fever virus (YFV) and West Nile virus (WNV), are an important public health concern in those countries where transmitter mosquitoes are endemic, several cases of travelers from those endemic countries have been recently reported in Europe. Thus, early diagnosis of these viruses is essential for patient management and adoption of preventive measures. An assay for the simultaneous detection of DENV, CHIKV, ZIKV, YFV and WNV based on a multiplex real-time (RT)-PCR and its usefulness for diagnosis in infection screenings and surveillance of arbovirus in non-endemic countries are described. Read More

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http://dx.doi.org/10.1016/j.jviromet.2019.03.014DOI Listing
June 2019
2 Reads

Preliminary Screening of Mosquito Spatial Distribution in Togo: With Special Focus on the Aedes (Diptera: Culicidae) Species.

J Med Entomol 2019 Mar 30. Epub 2019 Mar 30.

U.S. Naval Medical Research Unit No. 3 (NAMRU-3), U.S. Agency for International Development, Maadi, Cairo, Egypt.

The Togolese Republic has a tropical and humid climate which constitutes an ideal environment for mosquitoes to breed and transmit diseases. The Aedes mosquito is known to transmit yellow fever (YF), dengue, chikungunya, and Zika viruses in West Africa. Togo has been suffering from YF virus transmission, despite vaccination efforts. Read More

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https://academic.oup.com/jme/advance-article/doi/10.1093/jme
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http://dx.doi.org/10.1093/jme/tjz029DOI Listing
March 2019
3 Reads

Expression and purification of the truncated duck DTMUV NS5 protein and the subcellular localization of NS5 in vitro.

Poult Sci 2019 Mar 27. Epub 2019 Mar 27.

Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.

Duck Tembusu virus (DTMUV) non-structural protein 5 (NS5), which harbors an N-terminal methyltransferase (MTase) domain and a C-terminal RNA-dependent RNA polymerase (RdRp) domain, is central to virus replication. In this study, a sequence encoding amino acid residues 1-408 of NS5 was amplified and ligated into a pET32a vector to generate a pET32a-NS51-408 expression vector. Recombinant protein was expressed, purified, and used to arise a mouse anti-NS5 specific polyclonal antibody (DTMUV-NS51-408 mPAb). Read More

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http://dx.doi.org/10.3382/ps/pez117DOI Listing
March 2019
2 Reads
1.672 Impact Factor

The Conserved Molecular Determinants of Virulence in Dengue Virus.

Int J Med Sci 2019 24;16(3):355-365. Epub 2019 Jan 24.

Centre for Virus and Vaccine Research, School of Science and Technology, Sunway University, 47500 Subang Jaya, Selangor, Malaysia.

Dengue virus belongs to the Flaviviridae family which also includes viruses such as the Zika, West Nile and yellow fever virus. Dengue virus generally causes mild disease, however, more severe forms of the dengue virus infection, dengue haemorrhagic fever (DHF) and dengue haemorrhagic fever with shock syndrome (DSS) can also occur, resulting in multiple organ failure and even death, especially in children. The only dengue vaccine available in the market, CYD-TDV offers limited coverage for vaccinees from 9-45 years of age and is only recommended for individuals with prior dengue exposure. Read More

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http://dx.doi.org/10.7150/ijms.29938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428985PMC
January 2019
2 Reads

Anti-poliovirus activity of Nerium oleander aqueous extract.

Nat Prod Res 2019 Mar 25:1-4. Epub 2019 Mar 25.

c Frankincense Biodiversity Unit, Research Center , Dhofar University , Salalah , Oman.

Nerium oleander (NO), a member of the Apocynaceae family, is an ornamental plant. In this study, we evaluated the antiviral activity of hot and cold extract of NO against six different viruses such as herpes simplex virus type 1 (HSV-1), polio virus type 1 (Sb-1), vesicular stomatitis virus (VSV), reovirus type-1 (Reo-1), human immunodeficiency virus type-1 (HIV-1), and yellow fever virus (YFV). Interestingly the results of plaque reduction assay demonstrated that both, hot extract and cold extract (breastin) of NO inhibited Sb-1 viral infection. Read More

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http://dx.doi.org/10.1080/14786419.2019.1582046DOI Listing
March 2019
1 Read

Safe Travel Preparation for HIV-Infected Patients.

Curr Infect Dis Rep 2019 Mar 20;21(4):15. Epub 2019 Mar 20.

Infectious Disease & Geographic Medicine, Redwood City Kaiser, The Kaiser Permanente Medical Group, Travel Medicine Services, 1192 Veterans Blvd, Redwood City, CA, 94063, USA.

Purpose Of Review: Infectious diseases are a risk when traveling internationally, and it is important to know the potential disease burden of a region and take appropriate preventative actions before traveling. For individuals with HIV, there are special considerations and contradictions for various vaccines and medications as well as interactions with likely antiviral drugs. The purpose of this review is to summarize the vaccine and medication recommendations for travelers with HIV infection. Read More

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http://dx.doi.org/10.1007/s11908-019-0667-8DOI Listing
March 2019
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Male accessory gland molecules inhibit harmonic convergence in the mosquito Aedes aegypti.

Curr Biol 2019 Mar;29(6):R196-R197

Department of Entomology, Cornell University, 3131 Comstock Hall, Ithaca, NY 14853, USA. Electronic address:

Aedes aegypti mosquitoes transmit pathogens such as yellow fever, dengue, Zika, and chikungunya viruses to millions of human hosts annually [1]. As such, understanding Ae. aegypti courtship and mating biology could prove crucial to the success of disease control efforts that target reproduction. Read More

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http://dx.doi.org/10.1016/j.cub.2019.02.005DOI Listing
March 2019
1 Read

Rift Valley Fever Virus and Yellow Fever Virus in Urine: A Potential Source of Infection.

Virol Sin 2019 Mar 19. Epub 2019 Mar 19.

Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.

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http://dx.doi.org/10.1007/s12250-019-00096-2DOI Listing
March 2019
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Vector-borne transmission and evolution of Zika virus.

Nat Ecol Evol 2019 04 18;3(4):561-569. Epub 2019 Mar 18.

Laboratory of Vector Control Research, Unit Transmission Reservoir and Pathogen Diversity, Institute Pasteur of Guadeloupe, Les Abymes, Guadeloupe, France.

Zika virus (ZIKV), discovered in the Zika Forest of Uganda in 1947, is a mosquito-borne flavivirus related to yellow fever, dengue and West Nile viruses. From its discovery until 2007, only sporadic ZIKV cases were reported, with mild clinical manifestations in patients. Therefore, little attention was given to this virus before epidemics in the South Pacific and the Americas that began in 2013. Read More

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http://dx.doi.org/10.1038/s41559-019-0836-zDOI Listing
April 2019
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Climate change may enable Aedes aegypti infestation in major European cities by 2100.

Environ Res 2019 Feb 16;172:693-699. Epub 2019 Feb 16.

Department of Mathematics and Mathematical Statistics, Umeå University, Umeå, Sweden; Evolution and Ecology Program, International Institute for Applied Systems Analysis, Laxenburg, Austria.

Background: Climate change allows Aedes aegypti to infest new areas. Consequently, it enables the arboviruses the mosquito transmits -- e.g. Read More

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http://dx.doi.org/10.1016/j.envres.2019.02.026DOI Listing
February 2019
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Ecstasy Abuse and Its Effects on the Oral Mucosa.

J Craniofac Surg 2019 Mar 12. Epub 2019 Mar 12.

Oral Medicine, Department of Diagnosis and Surgery, Araraquara Dental School, Univ Estadual Paulista (UNESP), Araraquara.

Ecstasy is an illicit drug that has been increasingly abused by young people. This synthetic drug has both stimulant and hallucinogenic effects and is usually consumed in a tablet. The side effects of ecstasy use include nausea, muscle cramping, fever, and symptoms mostly linked to muscular tension including jaw pain, facial pain, and headaches. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005033DOI Listing
March 2019
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Heterologous Expression of Cation Chloride Cotransporter 2 (aeCCC2) in Oocytes Induces an Enigmatic Na⁺/Li⁺ Conductance.

Insects 2019 Mar 14;10(3). Epub 2019 Mar 14.

Department of Entomology, The Ohio State University, Ohio Agricultural Research and Development Center, Wooster, OH 44691, USA.

The yellow fever mosquito possesses three genes encoding putative Na⁺-coupled cation chloride cotransporters (CCCs): aeNKCC1, aeCCC2, and aeCCC3. To date, none of the aeCCCs have been functionally characterized. Here we expressed aeCCC2 heterologously in oocytes and measured the uptake of Li⁺ (a tracer for Na⁺) and Rb⁺ (a tracer for K⁺). Read More

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http://dx.doi.org/10.3390/insects10030071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468792PMC
March 2019
2 Reads

Impact of synthetic and biological immunomodulatory therapy on the duration of 17DD yellow fever vaccine-induced immunity in rheumatoid arthritis.

Arthritis Res Ther 2019 Mar 14;21(1):75. Epub 2019 Mar 14.

Departamento de Reumatologia, Hospital Universitário de Brasília, Universidade de Brasília, Brasília, DF, Brazil.

Background: The 17DD-yellow fever (YF) vaccine induces a long-lasting protective immunity, resulting from humoral and cellular immunological memory. The treatment of rheumatoid arthritis (RA) patients with disease-modifying anti-rheumatic drugs (DMARD) may affect pre-existing 17DD-vaccine protective immunity and increase the risk of acquiring YF infection. Our goal was to determine whether DMARD would affect the duration of YF-specific protective immunity in RA patients. Read More

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http://dx.doi.org/10.1186/s13075-019-1854-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419381PMC
March 2019
8 Reads

Hepatitis Rebound after Infection with Yellow Fever Virus.

Emerg Infect Dis 2019 Jun 17;25(6). Epub 2019 Jun 17.

In 2018, yellow fever with hepatitis was diagnosed for 2 unvaccinated travelers returning to France from Brazil. Hepatitis persisted for >6 months; liver enzyme levels again increased 2 months after disease onset with no detection of yellow fever virus RNA or other pathogens. Persistent hepatitis with hepatic cytolysis rebound probably resulted from immune response. Read More

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http://wwwnc.cdc.gov/eid/article/25/6/19-0069_article.htm
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http://dx.doi.org/10.3201/eid2506.190069DOI Listing
June 2019
7 Reads

Louse-borne relapsing fever (Borrelia recurrentis infection).

Authors:
David A Warrell

Epidemiol Infect 2019 Jan;147:e106

Nuffield Department of Clinical Medicine,University of Oxford,Oxford,UK.

Louse-borne relapsing fever (LBRF) is an epidemic disease with a fascinating history from Hippocrates' times, through the 6th century 'Yellow Plague', to epidemics in Ireland, Scotland and England in the 19th century and two large Afro-Middle Eastern pandemics in the 20th century. An endemic focus persists in Ethiopia and adjacent territories in the Horn of Africa. Since 2015, awareness of LBRF in Europe, as a re-emerging disease, has been increased dramatically by the discovery of this infection in dozens of refugees arriving from Africa. Read More

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http://dx.doi.org/10.1017/S0950268819000116DOI Listing
January 2019
4 Reads

Haemagogus leucocelaenus and Haemagogus janthinomys are the primary vectors in the major yellow fever outbreak in Brazil, 2016-2018.

Emerg Microbes Infect 2019 ;8(1):218-231

a Laboratório de Mosquitos Transmissores de Hematozoários , Instituto Oswaldo Cruz , Rio de Janeiro , RJ , Brazil.

The yellow fever virus (YFV) caused a severe outbreak in Brazil in 2016-2018 that rapidly spread across the Atlantic Forest in its most populated region without viral circulation for almost 80 years. A comprehensive entomological survey combining analysis of distribution, abundance and YFV natural infection in mosquitoes captured before and during the outbreak was conducted in 44 municipalities of five Brazilian states. In total, 17,662 mosquitoes of 89 species were collected. Read More

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http://dx.doi.org/10.1080/22221751.2019.1568180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455131PMC
January 2019
2 Reads

Laboratory Evaluation of Larvicidal and Oviposition Deterrent Properties of Edible Plant Oils for Potential Management of Aedes aegypti (Diptera: Culicidae) in Drinking Water Containers.

J Med Entomol 2019 Mar 11. Epub 2019 Mar 11.

Department of Entomology, University of Illinois at Urbana-Champaign, Urbana, IL.

The yellow fever mosquito, Aedes aegypti (Diptera: Culicidae) transmits several devastating arboviruses, including dengue, chikungunya, and Zika virus, making development of inexpensive and eco-friendly strategies for its control an urgent priority. We evaluated the lethality of 13 commonly used plant-derived edible oils against late-third instar Ae. aegypti and then tested the three most lethal oils for stage-specific differences in lethality. Read More

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http://dx.doi.org/10.1093/jme/tjz021DOI Listing
March 2019
1 Read

Broad spectrum anti-flavivirus pyridobenzothiazolones leading to less infective virions.

Antiviral Res 2019 Mar 6;167:6-12. Epub 2019 Mar 6.

UMR "Emergence des Pathologies Virales" (Aix-Marseille University - IRD 190 - Inserm 1207 - EHESP), Fondation IHU Méditerranée Infection, APHM Public Hospitals of Marseille, Faculté de Médecine, 27 bd Jean Moulin, 13005 Marseille, France. Electronic address:

We report the design, synthesis, and biological evaluation of a class of 1H-pyrido[2,1-b][1,3]benzothiazol-1-ones originated from compound 1, previously identified as anti-flavivirus agent. Some of the new compounds showed activity in low μM range with reasonable selectivity against Dengue 2, Yellow fever (Bolivia strain), and West Nile viruses. One of the most interesting molecules, compound 16, showed broad antiviral activity against additional flaviviruses such as Dengue 1, 3 and 4, Zika, Japanese encephalitis, several strains of Yellow fever, and tick-borne encephalitis viruses. Read More

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http://dx.doi.org/10.1016/j.antiviral.2019.03.004DOI Listing
March 2019
3 Reads

Multimodal floral cues guide mosquitoes to tansy inflorescences.

Sci Rep 2019 Mar 7;9(1):3908. Epub 2019 Mar 7.

Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, V5A 1S6, Canada.

Female mosquitoes exploit olfactory, CO, visual, and thermal cues to locate vertebrate hosts. Male and female mosquitoes also consume floral nectar that provides essential energy for flight and survival. Heretofore, nectar-foraging mosquitoes were thought to be guided solely by floral odorants. Read More

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http://dx.doi.org/10.1038/s41598-019-39748-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405845PMC
March 2019
2 Reads

A Phase II, Randomized, Double-blind, Controlled Safety and Immunogenicity Trial of Typhoid Conjugate Vaccine in Children Under 2 Years of Age in Ouagadougou, Burkina Faso: A Methods Paper.

Clin Infect Dis 2019 Mar;68(Supplement_2):S59-S66

Center for Vaccine Development and Global Health at the University of Maryland School of Medicine, Baltimore, MD.

The recent Typhoid Fever Surveillance in Africa Program demonstrated an overall adjusted incidence of typhoid fever 2-3 times higher than previous estimates in Africa. Recently, a single-dose typhoid conjugate vaccine that allows infants as young as 6 months old to be vaccinated was prequalified by the World Health Organization (WHO). This Vi-based conjugate vaccine demonstrated robust immunogenicity after 1 dose in infants and children 6 through 23 months of age in India with no safety signal, and is currently being tested for the first time on the African continent in Malawi. Read More

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http://dx.doi.org/10.1093/cid/ciy1104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405275PMC
March 2019
1 Read

Diagnosing Zika virus infection against a background of other flaviviruses: Studies in high resolution serological analysis.

Sci Rep 2019 Mar 6;9(1):3648. Epub 2019 Mar 6.

Division of Microbiology and Animal Hygiene, University of Goettingen, Goettingen, 37075, Germany.

Zika virus (ZIKV) is a mosquito-borne flavivirus. Homologous proteins of different flaviviruses display high degrees of sequence identity, especially within subgroups. This leads to extensive immunological cross-reactivity and corresponding problems for developing a ZIKV-specific serological assay. Read More

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http://dx.doi.org/10.1038/s41598-019-40224-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403343PMC
March 2019
1 Read

The cost of diagnostic uncertainty: a prospective economic analysis of febrile children attending an NHS emergency department.

BMC Med 2019 Mar 6;17(1):48. Epub 2019 Mar 6.

Institute of Infection and Global Health, University of Liverpool, 8 West Derby St, Liverpool, L69 7BE, UK.

Background: Paediatric fever is a common cause of emergency department (ED) attendance. A lack of prompt and definitive diagnostics makes it difficult to distinguish viral from potentially life-threatening bacterial causes, necessitating a cautious approach. This may result in extended periods of observation, additional radiography, and the precautionary use of antibiotics (ABs) prior to evidence of bacterial foci. Read More

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http://dx.doi.org/10.1186/s12916-019-1275-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402102PMC
March 2019
1 Read
7.249 Impact Factor

Past and future spread of the arbovirus vectors Aedes aegypti and Aedes albopictus.

Nat Microbiol 2019 May 4;4(5):854-863. Epub 2019 Mar 4.

School of BioSciences, University of Melbourne, Parkville, Victoria, Australia.

The global population at risk from mosquito-borne diseases-including dengue, yellow fever, chikungunya and Zika-is expanding in concert with changes in the distribution of two key vectors: Aedes aegypti and Aedes albopictus. The distribution of these species is largely driven by both human movement and the presence of suitable climate. Using statistical mapping techniques, we show that human movement patterns explain the spread of both species in Europe and the United States following their introduction. Read More

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http://dx.doi.org/10.1038/s41564-019-0376-yDOI Listing
May 2019
10 Reads

Yellow fever: is Asia prepared for an epidemic?

Lancet Infect Dis 2019 Mar;19(3):241-242

Global Dengue and Aedes-transmitted Diseases Consortium, Seoul, Korea.

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http://dx.doi.org/10.1016/S1473-3099(19)30050-7DOI Listing
March 2019
4 Reads