7,203 results match your criteria Yellow Fever


Biting Deterrency of Undecanoic Acid and Dodecanoic Acid Ester Analogs Against Aedes aegypti.

Pest Manag Sci 2020 Jul 10. Epub 2020 Jul 10.

National Center for Natural Products Research, The University of Mississippi, University, Mississippi, 38677, USA.

Background: Mosquitoes remain one of the most significant threats to the health of humans throughout the world. This study was designed to evaluate the biting deterrent effects of a series of ester analogs of undecanoic (C:11:0) and dodecanoic acids (C:12:0) against Aedes aegypti (L), (Diptera: Culicidae), the yellow fever mosquito, using K&D and A&K bioassay systems.

Results: In the K&D bioassays, C:11:0 esters methyl undecanoate, propyl undecanoate, butyl undecanoate, and pentyl undecanoate, and the C:12:0 esters methyl dodecanoate, ethyl dodecanoate, propyl dodecanoate, octyl dodecanoate, and dodecyl dodecanoate were most active. Read More

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http://dx.doi.org/10.1002/ps.5994DOI Listing

Nanosensors based on LSPR are able to serologically differentiate dengue from Zika infections.

Sci Rep 2020 Jul 9;10(1):11302. Epub 2020 Jul 9.

Laboratório de Virologia Básica e Aplicada, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

The Flaviviridae virus family was named after the Yellow-fever virus, and the latin term flavi means "of golden color". Dengue, caused by Dengue virus (DENV), is one of the most important infectious diseases worldwide. A sensitive and differential diagnosis is crucial for patient management, especially due to the occurrence of serological cross-reactivity to other co-circulating flaviviruses. Read More

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http://dx.doi.org/10.1038/s41598-020-68357-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347616PMC

Identification of a superagonist variant of the immunodominant Yellow fever virus epitope NS4b by combinatorial peptide library screening.

Mol Immunol 2020 Jul 6;125:43-50. Epub 2020 Jul 6.

Department of Oncology, Lausanne University Hospital (CHUV), Lausanne, Switzerland. Electronic address:

The CD8 T cell response to the HLA-A2-restricted epitope LLWNGPMAV (LLW) of the non-structural protein 4b of Yellow Fever Virus (YFV) is remarkably immunodominant, highly prevalent and powerful in YFV-vaccinated humans. Here we used a combinatorial peptide library screening in the context of an A2/LLW-specific CD8 T cell clone to identify a superagonist that features a methionine to isoleucine substitution at position 7. Based on in silico modeling, the functional enhancement of this LLW-7I mutation was associated with alterations in the structural dynamics of the peptide in the major histocompatibility complex (pMHC) binding with the T cell receptor (TCR). Read More

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http://dx.doi.org/10.1016/j.molimm.2020.06.025DOI Listing

LY6E Restricts the Entry of Human Coronaviruses, Including the Currently Pandemic SARS-CoV-2.

J Virol 2020 Jul 8. Epub 2020 Jul 8.

Baruch S. Blumberg Institute, Hepatitis B Foundation, 3805 Old Easton Road, Doylestown, PA 18902. USA.

C3A is a sub-clone of human hepatoblastoma HepG2 cell line with strong contact inhibition of growth. We fortuitously found that C3A was more susceptible to human coronavirus HCoV-OC43 infection than HepG2, which was attributed to the increased efficiency of virus entry into C3A cells. In an effort to search for the host cellular protein(s) mediating the differential susceptibility of the two cell lines to HCoV-OC43 infection, we found that ArfGAP with dual pleckstrin homology (PH) domains 2 (ADAP2), gamma-interferon-inducible lysosome/endosome-localized thiolreductase (GILT) and lymphocyte antigen 6 family member E (LY6E), the three cellular proteins with identified function of interfering virus entry, expressed at significantly higher levels in HepG2 cells. Read More

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http://dx.doi.org/10.1128/JVI.00562-20DOI Listing

Health diplomacy across borders: the case of yellow fever and COVID-19.

J Travel Med 2020 Jul 8. Epub 2020 Jul 8.

Oxford Vaccine Group and Oxford Martin School, University of Oxford, 34 Broad St, OX1 3BD.

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http://dx.doi.org/10.1093/jtm/taaa112DOI Listing

Reprogramming of the Antibacterial Drug Vancomycin Results in Potent Antiviral Agents Devoid of Antibacterial Activity.

Pharmaceuticals (Basel) 2020 Jun 29;13(7). Epub 2020 Jun 29.

Department of Pharmaceutical Chemistry, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary.

Influenza A and B viruses are a global threat to human health and increasing resistance to the existing antiviral drugs necessitates new concepts to expand the therapeutic options. Glycopeptide derivatives have emerged as a promising new class of antiviral agents. To avoid potential antibiotic resistance, these antiviral glycopeptides are preferably devoid of antibiotic activity. Read More

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http://dx.doi.org/10.3390/ph13070139DOI Listing

Etiology of Community-Acquired Pneumonia Requiring Hospital Admission in Adults with and Without Cancers: A Single-Center Retrospective Study in China.

Infect Drug Resist 2020 8;13:1607-1617. Epub 2020 Jun 8.

Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Air Force Medical University, Xi'an, People's Republic of China.

Background: The etiology and distribution of community-acquired pneumonia (CAP) vary periodically and geographically. The clinical evaluation of CAP among patients with cancers remains unknown.

Patients And Methods: This retrospective hospital-based study on adult CAP was conducted in Tang Du Hospital, China, from September 2018 to August 2019. Read More

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http://dx.doi.org/10.2147/IDR.S251564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294101PMC

Ross River Virus Provokes Differentially Expressed MicroRNA and RNA Interference Responses in Mosquitoes.

Viruses 2020 Jun 27;12(7). Epub 2020 Jun 27.

Australian Infectious Disease Research Centre, School of Biological Sciences, The University of Queensland, Brisbane, QLD 4072, Australia.

Alphaviruses are globally distributed and predominately transmitted by mosquitoes. species are common vectors for the clinically important alphaviruses-Chikungunya, Sindbis, and Ross River (RRV) viruses-with also being a vector for the flaviviruses dengue, Yellow Fever, and Zika viruses. was putatively implicated in the large 1979-1980 South Pacific Islands outbreak of RRV-the leading cause of arboviral disease in Australia today. Read More

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http://dx.doi.org/10.3390/v12070695DOI Listing

Founding Physicians of the Medical College of Georgia and Their Connections to Crawford Long and the First Surgical Anesthetic.

Authors:
James B Mayfield

J Anesth Hist 2020 Jun 6;6(2):38-41. Epub 2019 Sep 6.

Department of Anesthesiology and Perioperative Medicine, Medical College of Georgia, Augusta University, 1120 15(th) St, BI-2047, Augusta, GA 30912-2700. Electronic address:

Milton Antony (1789-1839), an apprenticed trained physician, began educating medical apprentices in 1826 and helped to establish the Medical College of Georgia (MCG) in 1829. Antony recruited additional faculty, Louis Dugas (anatomy and physiology), and Paul Eve (surgery), and together they worked to promote the dissemination of new medical knowledge and enhance and reform medical education. As a result of their efforts, the Southern Medical and Surgical Journal (SMSJ) was established in 1836. Read More

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http://dx.doi.org/10.1016/j.janh.2019.08.002DOI Listing

Incursion pathways of the Asian tiger mosquito (Aedes albopictus) into Australia contrast sharply with those of the yellow fever mosquito (Aedes aegypti).

Pest Manag Sci 2020 Jun 27. Epub 2020 Jun 27.

School of BioSciences, Bio21 Institute, University of Melbourne, Parkville, Victoria, Australia.

Background: Understanding pest incursion pathways is critical for preventing new invasions and for stopping the transfer of alleles that reduce the efficacy of local control methods. The mosquitoes Aedes albopictus (Skuse) and Ae. aegypti (Linnaeus) are both highly invasive disease vectors, and through a series of ongoing international incursions are continuing to colonise new regions and spread insecticide resistance alleles among established populations. Read More

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http://dx.doi.org/10.1002/ps.5977DOI Listing

Concurrent amplification of Zika, chikungunya, and yellow fever virus in a sylvatic focus of arboviruses in Southeastern Senegal, 2015.

BMC Microbiol 2020 Jun 26;20(1):181. Epub 2020 Jun 26.

Pôle de Zoologie Médicale, Institut Pasteur de Dakar, 36 Avenue Pasteur, BP 220, Dakar, Senegal.

Background: Chikungunya (CHIKV), yellow fever (YFV) and Zika (ZIKV) viruses circulate in sylvatic transmission cycles in southeastern Senegal, where they share common hosts and vectors. All three viruses undergo periodic amplifications, during which they are detected in mosquitoes and sometimes in hosts. However, little is known about their spatio-temporal patterns in years in which they undergo concurrent amplification. Read More

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http://dx.doi.org/10.1186/s12866-020-01866-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318437PMC

Investigation of the ability of the oviposition-stimulant lectin from Moringa oleifera seeds (WSMoL) to bind with membrane proteins present in the legs of Aedes aegypti.

Int J Biol Macromol 2020 Jun 22;162:657-662. Epub 2020 Jun 22.

Departamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco, Recife, Brazil. Electronic address:

The mosquito Aedes aegypti L. is a vector transmitting diseases such as dengue, chikungunya and Zika virus fever. The water-soluble lectin from Moringa oleifera Lam. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.06.189DOI Listing

Surveillance system assessment in Guinea: Training needed to strengthen data quality and analysis, 2016.

PLoS One 2020 25;15(6):e0234796. Epub 2020 Jun 25.

RTI International, Research Triangle Park, North Carolina, United States of America.

The 2014-2016 Ebola virus disease outbreak revealed the fragility of the Guinean public health infrastructure. As a result, the Guinean Ministry of Health is collaborating with international partners to improve compliance with the International Health Regulations and work toward the Global Health Security Agenda goals, including enhanced case- and community-based disease surveillance. We assessed the case-based disease surveillance system during October 1, 2015-March 31, 2016, in the Boffa prefecture of Guinea. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234796PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316275PMC

Positively selected variants in functionally important regions of TLR7 in Alouatta guariba clamitans with yellow fever virus exposure in Northern Argentina.

Am J Phys Anthropol 2020 Jun 25:e24086. Epub 2020 Jun 25.

Department of Anthropology, University of Utah, Salt Lake City, Utah, USA.

Background: In 2007-2009, a major yellow fever virus (YFV) outbreak in Northern Argentina decimated the local howler monkey (Alouatta) population.

Aims: To evaluate whether the surviving howler monkeys possess advantageous genetic variants inherited from monkeys alive prior to the YFV outbreak, we explored the relationship between Toll-like receptor (TLR) 7 and TLR8 gene variation and YFV susceptibility.

Methods: We used samples from Alouatta individuals in Misiones, Argentina alive before the YFV outbreak, individuals that died during the outbreak, and individuals that survived the outbreak and are alive today. Read More

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http://dx.doi.org/10.1002/ajpa.24086DOI Listing

Flavivirus Infection Associated with Cerebrovascular Events.

Viruses 2020 Jun 22;12(6). Epub 2020 Jun 22.

Department of Infectious, Dermatological and Parasitic Infections, Sao Jose do Rio Preto Medical School, Sao Jose do Rio Preto 15090-000, Brazil.

Arthropod-borne viruses (arboviruses) of the genus are distributed globally and cause significant human disease and mortality annually. Flavivirus infections present a spectrum of clinical manifestations, ranging from asymptomatic to severe manifestations, including hemorrhage, encephalitis and death. Herein, we describe 3 case reports of cerebrovascular involvement in patients infected by dengue and Zika viruses in Sao Jose do Rio Preto, São Paulo State, Brazil, a hyperendemic area for arbovirus circulation, including dengue, yellow fever, chikungunya and Saint Louis encephalitis viruses. Read More

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http://dx.doi.org/10.3390/v12060671DOI Listing

Hepatitis Relapse after Yellow Fever Infection: Is There Another Wave?

Rev Soc Bras Med Trop 2020 22;53:e20200152. Epub 2020 Jun 22.

Universidade Federal de Minas Gerais, Hospital das Clínicas, Instituto Alfa de Gastroenterologia, Belo Horizonte, MG, Brasil.

During the yellow fever (YF) outbreak in Brazil, many cases of fulminant hepatitis were seen, although mild to moderate hepatitis was mostly observed with complete recovery. This report presents a case of late-onset hepatitis due to YF relapse. The patient sought medical attention after jaundice recurrence 40 days after the first YF hepatitis episode. Read More

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http://dx.doi.org/10.1590/0037-8682-0152-2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310355PMC

[Study on traditional Chinese medicine common syndrome characteristic of coronavirus disease 2019 based on latent structure combined with system clustering analysis].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2020 May;32(5):537-543

Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan and Education Ministry of China, Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine, Zhengzhou 450046, Henan, China.

Objective: To investigate traditional Chinese medicine (TCM) common syndrome characteristic of coronavirus disease 2019 (COVID-19), thus providing evidence for clinical differentiation.

Methods: The COVID-19 TCM treatment plan and syndrome related literature published before February 24, 2020 was searched and a database was established. TCM common syndrome characteristics of COVID-19 were analyzed by the method of latent structure and system clustering combined with frequency and constituent ratio, which were conducted by Lantern 5. Read More

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http://dx.doi.org/10.3760/cma.j.cn121430-20200506-00620DOI Listing

Forced Zika Virus Infection of Leads to Limited Virus Accumulation in Mosquito Saliva.

Viruses 2020 Jun 19;12(6). Epub 2020 Jun 19.

Laboratory of Virology, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands.

Zika virus (ZIKV) is a mosquito-borne pathogen that caused a large outbreak in the Americas in 2015 and 2016. The virus is currently present in tropical areas around the globe and can cause severe disease in humans, including Guillain-Barré syndrome and congenital microcephaly. The tropical yellow fever mosquito, , is the main vector in the urban transmission cycles of ZIKV. Read More

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http://dx.doi.org/10.3390/v12060659DOI Listing

Using recombination-dependent lethal mutations to stabilize reporter flaviviruses for rapid serodiagnosis and drug discovery.

EBioMedicine 2020 Jun 20;57:102838. Epub 2020 Jun 20.

Department of Biology and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA; Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, TX, USA; Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX, USA. Electronic address:

Background: Many flaviviruses are significant human pathogens that cause global public health threats. Developing research tools for studying and diagnosing these pathogens is a top priority. Reporter flaviviruses are useful tools for studying viral pathogenesis, diagnosing disease, and screening antiviral compounds. Read More

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http://dx.doi.org/10.1016/j.ebiom.2020.102838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317239PMC

Small-molecule inhibitors of TBK1 serve as an adjuvant for a plasmid-launched live-attenuated yellow fever vaccine.

Hum Vaccin Immunother 2020 Jun 23:1-8. Epub 2020 Jun 23.

KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Molecular Vaccinology and Vaccine Discovery Group , Leuven, Belgium.

Plasmid-launched live-attenuated vaccines (PLLAV), also called infectious DNA (iDNA) vaccines, combine the assets of genetic immunization with the potency of replication-competent live viral vaccines. However, due to their origin as bacterial plasmid DNA, efficient delivery of PLLAV may be hampered by innate signaling pathways such as the cGAS-STING-mediated sensing of cytosolic DNA, resulting in an unfavorable proinflammatory and antiviral response locally at the site of immunization. Employing several complementary cell-based systems and using the yellow fever vaccine (YF17D) and the respective PLLAV-YF17D, we screened a panel of small molecules known to interfere with antiviral signaling for their proviral activity and identified two potent inhibitors of the TANK-binding kinase 1 (TBK1), BX795 and CYT387, to enhance YF17D replication and hence efficacy of PLLAV-YF17D transfection. Read More

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http://dx.doi.org/10.1080/21645515.2020.1765621DOI Listing
June 2020
2.131 Impact Factor

Virus harvesting in perfusion culture: Choosing the right type of hollow fiber membrane.

Biotechnol Bioeng 2020 Jun 22. Epub 2020 Jun 22.

Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany.

The use of bioreactors coupled to membrane-based perfusion systems enables very high cell and product concentrations in vaccine and viral vector manufacturing. Many virus particles, however, are not stable and either lose their infectivity or physically degrade resulting in significant product losses if not harvested continuously. Even hollow fiber membranes with a nominal pore size of 0. Read More

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http://dx.doi.org/10.1002/bit.27470DOI Listing

Tuberculosis-associated chylothorax revealing an enlarged lymphatic duct due to tuberculosis lymphadenitis.

Respirol Case Rep 2020 Aug 18;8(6):e00600. Epub 2020 Jun 18.

Department of Respiratory Medicine Kyorin University School of Medicine Mitaka City Tokyo Japan.

A 77-year-old woman presented to our hospital with complaints of persistent cough and low-grade fever for two months. On radiological analysis, she had moderate right-sided pleural effusion with right hilar and subcarinal lymphadenopathies. Thoracentesis showed chylothorax of unknown cause. Read More

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http://dx.doi.org/10.1002/rcr2.600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301284PMC

Mobile Laboratory Reveals the Circulation of Dengue Virus Serotype I of Asian Origin in Medina Gounass (Guediawaye), Senegal.

Diagnostics (Basel) 2020 Jun 16;10(6). Epub 2020 Jun 16.

Arboviruses and Hemorrhagic Fever Viruses Unit, Virology Department, Institut Pasteur de Dakar, BP220 Dakar, Senegal.

With the growing success of controlling malaria in Sub-Saharan Africa, the incidence of fever due to malaria is in decline, whereas the proportion of patients with non-malaria febrile illness (NMFI) is increasing. Clinical diagnosis of NMFI is hampered by unspecific symptoms, but early diagnosis is a key factor for both better patient care and disease control. The aim of this study was to determine the arboviral aetiologies of NMFI in low resource settings, using a mobile laboratory based on recombinase polymerase amplification (RPA) assays. Read More

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http://dx.doi.org/10.3390/diagnostics10060408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345902PMC

Completeness of yellow fever notification forms in the state of Espírito Santo, Brazil, 2017.

Epidemiol Serv Saude 2020 10;29(3):e2019402. Epub 2020 Jun 10.

Programa de Pós-Graduação em Saúde Coletiva, Universidade Federal do Espírito Santo, Vitória, ES, Brasil.

Objective to describe the completeness of data on yellow fever notification forms in the municipalities of the state of Espírito Santo, Brazil, in 2017. Methods this is a descriptive ecological study with data from the Notifiable Health Conditions Information System (SINAN); form completeness was categorized as poor (<70.0%), regular (70-89. Read More

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http://dx.doi.org/10.5123/s1679-49742020000300014DOI Listing

Antigenic Characterization of New Lineage II Insect-Specific Flaviviruses in Australian Mosquitoes and Identification of Host Restriction Factors.

mSphere 2020 Jun 17;5(3). Epub 2020 Jun 17.

School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Queensland, Australia

We describe two new insect-specific flaviviruses (ISFs) isolated from mosquitoes in Australia, Binjari virus (BinJV) and Hidden Valley virus (HVV), that grow efficiently in mosquito cells but fail to replicate in a range of vertebrate cell lines. Phylogenetic analysis revealed that BinJV and HVV were closely related (90% amino acid sequence identity) and clustered with lineage II (dual-host affiliated) ISFs, including the Lammi and Nounané viruses. Using a panel of monoclonal antibodies prepared to BinJV viral proteins, we confirmed a close relationship between HVV and BinJV and revealed that they were antigenically quite divergent from other lineage II ISFs. Read More

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http://dx.doi.org/10.1128/mSphere.00095-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300350PMC

Vesicular stomatitis virus and DNA vaccines expressing Zika virus nonstructural protein 1 (NS1) induce substantial but not sterilizing protection against Zika virus infection.

J Virol 2020 Jun 17. Epub 2020 Jun 17.

Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio

The nonstructural protein 1 (NS1) of several flaviviruses, including West Nile, dengue, and yellow fever viruses, is capable of inducing variable degrees of protection against flavivirus infection in animal models. However, the immunogenicity of NS1 protein of Zika virus (ZIKV) is less understood. Here, we determined the efficacy of ZIKV NS1-based vaccine candidates using two delivery platforms, methyltransferase-defective recombinant vesicular stomatitis virus (mtdVSV) and a DNA vaccine. Read More

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http://dx.doi.org/10.1128/JVI.00048-20DOI Listing

An analysis of International Health Regulations Emergency Committees and Public Health Emergency of International Concern Designations.

BMJ Glob Health 2020 06;5(6)

Johns Hopkins Center for Health Security, Baltimore, Maryland, USA.

Introduction: Nine events have been assessed for potential declaration of a Public Health Emergency of International Concern (PHEIC). A PHEIC is defined as an extraordinary event that constitutes a public health risk to other states through international spread and requires a coordinated international response. The WHO Director-General convenes Emergency Committees (ECs) to provide their advice on whether an event constitutes a PHEIC. Read More

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http://dx.doi.org/10.1136/bmjgh-2020-002502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299007PMC

Performance of Eastern Mediterranean Region laboratories in the World Health Organization external quality assessment programme for arbovirus diagnostics.

East Mediterr Health J 2020 May 21;26(5):616-619. Epub 2020 May 21.

World Health Organization Regional Office for the Eastern Mediterranean, Cairo, Egypt.

Background: Arboviruses such as dengue virus, yellow fever virus, Zika virus and chikungunya virus are major threats to human health globally, including countries in the Eastern Mediterranean Region (EMR).

Aims: This study aimed to assess laboratory proficiency in EMR countries for detection of dengue virus, yellow fever virus, Zika virus and chikungunya virus.

Methods: A global external quality assessment programme for arbovirus diagnostics was developed and run in 2016 and 2018. Read More

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http://dx.doi.org/10.26719/emhj.20.015DOI Listing

Field notes from the Nigeria Centre for Disease Control 2019 pilot internship program for resident doctors.

Pan Afr Med J 2020 25;35:88. Epub 2020 Mar 25.

Nigeria Center for Disease Control, Abuja, Nigeria.

The 10-week internship for the pilot cohort of resident doctors from various teaching hospitals in Nigeria was a very rewarding experience. The internship was a beautiful immersion into field epidemiology, rumor surveillance, risk communication, digital tools for surveillance, developing strategic documents, line lists interpretation, weekly presentations and outbreak response coordination alongside working briefly as an incident manager for the Yellow Fever technical working group. Some of the learning points included: meeting coordination, contributions to ongoing research, review of training documents for surveillance officers and the mechanisms of escalating and de-escalating technical working groups in the face of outbreaks and working as an incident manager. Read More

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http://dx.doi.org/10.11604/pamj.2020.35.88.20583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250201PMC

Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen.

J Antibiot (Tokyo) 2020 Jun 12. Epub 2020 Jun 12.

Kish International Campus, University of Tehran, Tehran, Iran.

Ivermectin proposes many potentials effects to treat a range of diseases, with its antimicrobial, antiviral, and anti-cancer properties as a wonder drug. It is highly effective against many microorganisms including some viruses. In this comprehensive systematic review, antiviral effects of ivermectin are summarized including in vitro and in vivo studies over the past 50 years. Read More

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http://dx.doi.org/10.1038/s41429-020-0336-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290143PMC

Environmental influences on Aedes aegypti catches in Biogents Sentinel traps during a Californian "rear and release" program: Implications for designing surveillance programs.

PLoS Negl Trop Dis 2020 Jun 12;14(6):e0008367. Epub 2020 Jun 12.

College of Public Health, Medical and Veterinary Sciences, James Cook University, Smithfield, Australia.

As Aedes aegypti continues to expand its global distribution, the diseases it vectors (dengue, Zika, chikungunya and yellow fever) are of increasing concern. Modern efforts to control this species include "rear and release" strategies where lab-reared mosquitoes are distributed throughout the landscape to replace or suppress invasive populations. These programs require intensive surveillance efforts to monitor their success, and the Biogents Sentinel (BGS) trap is one of the most effective tools for sampling adult Ae. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314095PMC

Receptor Characterization and Functional Activity of Pyrokinins on the Hindgut in the Adult Mosquito, .

Front Physiol 2020 21;11:490. Epub 2020 May 21.

Laboratory of Integrative Vector Neuroendocrinology, Department of Biology, York University, Toronto, ON, Canada.

Pyrokinins are structurally related insect neuropeptides, characterized by their myotropic, pheromonotropic and melanotropic roles in some insects, but their function is unclear in blood-feeding arthropods. In the present study, we functionally characterized the pyrokinin-1 and pyrokinin-2 receptors (PK1-R and PK2-R, respectively), in the yellow fever mosquito, , using a heterologous cell system to characterize their selective and dose-responsive activation by members of two distinct pyrokinin subfamilies. We also assessed transcript-level expression of these receptors in adult organs and found the highest level of PK1-R transcript in the posterior hindgut (rectum) while PK2-R expression was enriched in the anterior hindgut (ileum) as well as in reproductive organs, suggesting these to be prominent target sites for their peptidergic ligands. Read More

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http://dx.doi.org/10.3389/fphys.2020.00490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255104PMC

Identification of Aedes aegypti specificity motifs in the N-terminus of the Bacillus thuringiensis Cry2Aa pesticidal protein.

J Invertebr Pathol 2020 Jun 7;174:107423. Epub 2020 Jun 7.

School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK. Electronic address:

One advantage of using the Cry proteins of Bacillus thuringiensis as pesticides is their relatively narrow spectrum of activity, thus reducing the risk of non-target effects. Understanding the molecular basis of specificity has the potential to help us design improved products against emerging pests, or against pests that have developed resistance to other Cry proteins. Many previous studies have associated specificity with the binding of the Cry protein, particularly through the apical regions of domain II, to particular receptors on the midgut epithelial cells of the host insect. Read More

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http://dx.doi.org/10.1016/j.jip.2020.107423DOI Listing
June 2020
2.110 Impact Factor

Neuromyelitis optica associated with yellow fever vaccination.

Acta Neurol Belg 2020 Jun 10. Epub 2020 Jun 10.

Department of Neurology, Hospital e Maternidade São José dos Pinhais, São José dos Pinhais, Brazil.

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http://dx.doi.org/10.1007/s13760-020-01396-1DOI Listing

Susceptibility of mosquito vectors of the city of Praia, Cabo Verde, to Temephos and Bacillus thuringiensis var israelensis.

PLoS One 2020 10;15(6):e0234242. Epub 2020 Jun 10.

Unidade de Ciências da Natureza, da Vida e do Ambiente, Universidade Jean Piaget de Cabo Verde, Praia, Cabo Verde.

Many vector-borne diseases circulate in the Republic of Cabo Verde. These include malaria during the colonization of the archipelago by the Portuguese explorers and several arboviruses such as yellow fever (now eradicated), dengue and zika. To control these vector-borne diseases, an integrated vector control program was implemented. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234242PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286513PMC

Topoisomerase III-ß is required for efficient replication of positive-sense RNA viruses.

bioRxiv 2020 Mar 27. Epub 2020 Mar 27.

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA.

Based on genome-scale loss-of-function screens we discovered that Topoisomerase III-ß (TOP3B), a human topoisomerase that acts on DNA and RNA, is required for yellow fever virus and dengue virus-2 replication. Remarkably, we found that TOP3B is required for efficient replication of all positive-sense-single stranded RNA viruses tested, including SARS-CoV-2. While there are no drugs that specifically inhibit this topoisomerase, we posit that TOP3B is an attractive anti-viral target. Read More

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http://dx.doi.org/10.1101/2020.03.24.005900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239047PMC

Genome Detective Coronavirus Typing Tool for rapid identification and characterization of novel coronavirus genomes.

bioRxiv 2020 Feb 2. Epub 2020 Feb 2.

KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

Genome Detective is a web-based, user-friendly software application to quickly and accurately assemble all known virus genomes from next generation sequencing datasets. This application allows the identification of phylogenetic clusters and genotypes from assembled genomes in FASTA format. Since its release in 2019, we have produced a number of typing tools for emergent viruses that have caused large outbreaks, such as Zika and Yellow Fever Virus in Brazil. Read More

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http://dx.doi.org/10.1101/2020.01.31.928796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217295PMC
February 2020

Awareness of Inadvertent Use of Yellow Fever Vaccine Among Recipients of Renal Transplant.

Transplant Proc 2020 Jun 3;52(5):1291-1293. Epub 2020 Jun 3.

Division of Infectious Diseases, Hospital das Clinicas, University of São Paulo Medical School, São Paulo, Brazil.

Yellow fever (YF) is a vaccine-preventable disease, but live attenuated YF vaccine (YFV) is contraindicated in immunosuppressed patients due to the risk of life-threatening YFV-associated side effects. This study aimed to evaluate 1. the knowledge of renal transplant recipients (RTRs) about the contraindication and risks of YFV; 2. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.02.182DOI Listing

[Experience of application of IgY-technology for laboratory diagnostics of viral infections.]

Vopr Virusol 2020;65(1):21-26

Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Moscow, 108819, Russia.

Introduction: The well-known advantages of class Y antibodies (IgY) from egg yolks of immunized hens in comparison with class G antibodies (IgG) of laboratory animals traditionally used in laboratory diagnosis of infectious diseases determine the stable interest of researchers in using IgY for these purposes (IgY technology). Over the past 20 years, the obvious benefits of IgY technology have been demonstrated for a number of viral and bacterial infections. Goals and objectives. Read More

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http://dx.doi.org/10.36233/0507-4088-2020-65-1-21-26DOI Listing
January 2020

The search for yellow fever virus vaccine in breast milk of inadvertently vaccinated women in Brazil.

Rev Inst Med Trop Sao Paulo 2020 29;62:e33. Epub 2020 May 29.

Centro de Vigilância Epidemiológica "Prof. Alexandre Vranjac", Coordenadoria de Controle de Doenças, Secretaria de Estado da Saúde, São Paulo, São Paulo, Brazil.

Eleven lactating women were inadvertently vaccinated with 17DD yellow fever vaccine in a small city of Sao Paulo State, Brazil. Their infants were being exclusively breast-fed and the breastfeeding was interrupted for 10 days. Serum and breastmilk were collected from the vaccinated mothers and tested for the presence of genomic RNA of the vaccine strain 8, 10 and 15 days after vaccination. Read More

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http://dx.doi.org/10.1590/s1678-9946202062033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266614PMC

Assessment of Resistance to Organophosphates and Pyrethroids in Aedes aegypti (Diptera: Culicidae): Do Synergists Affect Mortality?

J Med Entomol 2020 Jun 2. Epub 2020 Jun 2.

Environmental Health Sciences Program, Department of Health Education and Promotion, College of Health and Human Performance, East Carolina University, Greenville, NC.

Aedes aegypti (L.) is the primary vector of Zika, dengue, yellow fever, and chikungunya viruses. Insecticides used in mosquito control can help prevent the spread of vector-borne diseases. Read More

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http://dx.doi.org/10.1093/jme/tjaa101DOI Listing

Nocturnal Mosquitoes of Pará State in the Brazilian Amazon: Species Composition, Habitat Segregation, and Seasonal Variation.

J Med Entomol 2020 Jun 2. Epub 2020 Jun 2.

Departamento de Biologia Geral, Centro de Ciências Biológicas e da Saúde.

Mosquitoes (Diptera: Culicidae) are one of the most important disease vector species in the world. Many species have a high degree of anthropophilia and are often found in human habitations. In the present study, we have inventoried the nocturnal mosquito assemblage in intra-, peri-, and extradomicile environments in four municipalities in Pará, Brazil. Read More

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http://dx.doi.org/10.1093/jme/tjaa103DOI Listing

The limited knowledge of placental damage due to neglected infections: ongoing problems in Latin America.

Syst Biol Reprod Med 2020 Jun;66(3):151-169

Laboratory of Vascular Biology and Histopathology, Institute of Health Sciences and Health, Federal University of Mato Grosso , Barra Do Garcas, Brazil.

The placenta works as a selective barrier, protecting the fetus from potential infections that may affect the maternal organism during pregnancy. In this review, we will discuss several challenging infections that are common within Latin American countries and that may affect the maternal-fetal interface and pose risks to fetal development. Specifically, we will focus on emerging infectious diseases including the arboviruses, malaria, leishmaniasis, and the bacterial foodborne disease caused by Shiga toxin-producing . Read More

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http://dx.doi.org/10.1080/19396368.2020.1753850DOI Listing

Repurposing Old Antibodies for New Diseases by Exploiting Cross-Reactivity and Multicolored Nanoparticles.

ACS Nano 2020 Jun 4;14(6):6626-6635. Epub 2020 Jun 4.

Department of Engineering, University of Massachusetts Boston, Boston, Massachusetts 02125, United States.

We exploit the cross-reactivity of dengue (DENV) and Zika (ZIKV) virus polyclonal antibodies for nonstructural protein 1 (NS1) to construct a selective sensor that can detect yellow fever virus (YFV) NS1 in a manner similar to chemical olfaction. DENV and ZIKV antibodies were screened for their ability to bind to DENV, ZIKV, and YFV NS1 by enzyme linked immunosorbent assay (ELISA) and in pairs in paper immunoassays. A strategic arrangement of antibodies immobilized on paper and conjugated to different colored gold NPs was used to distinguish the three biomarkers. Read More

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http://dx.doi.org/10.1021/acsnano.9b09049DOI Listing

RNA Interference Is Enhanced by Knockdown of double-stranded RNases in the Yellow Fever Mosquito .

Insects 2020 May 27;11(6). Epub 2020 May 27.

Department of Biological Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.

RNA interference (RNAi) techniques are being developed for a range of pest insect control technologies, including the sterile insect technique (SIT) and double-stranded RNA (dsRNA)-based insecticides. In SIT applications, where >99% of the released males should be sterile to meet industry standards, the efficiency of RNAi will need to be improved for many insect species if this technology is to be adopted. Endogenous dsRNases can impede dsRNA delivery in some insects, and, here, we investigated whether dsRNases in the midgut could limit RNAi efficacy in the mosquito . Read More

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http://dx.doi.org/10.3390/insects11060327DOI Listing

Severe Multiorgan Failure Following Yellow Fever Vaccination.

Vaccines (Basel) 2020 May 26;8(2). Epub 2020 May 26.

Center for Infectious Diseases, Virology, University Hospital of Heidelberg, 69120 Heidelberg, Germany.

Background: The yellow fever (YF) vaccination is recommended by the WHO for people traveling or living in endemic areas at risk for yellow fever infections in Africa and South America. Although the live attenuated yellow fever vaccine is a safe and efficient vaccine, rare serious adverse events after vaccination have been reported.

Case Presentation: We present the case of a 74-year-old male with multiorgan failure after yellow fever vaccination for a trip to Brazil. Read More

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http://dx.doi.org/10.3390/vaccines8020249DOI Listing

Zika virus subversion of chaperone GRP78/BiP expression in A549 cells during UPR activation.

Biochimie 2020 May 25;175:99-105. Epub 2020 May 25.

Université de La Réunion, INSERM UMR 1187, CNRS 9192, IRD 249, PIMIT, Processus Infectieux en Milieu Insulaire Tropical, Plateforme CYROI, 2, Rue Maxime Rivière, 97490 Sainte-Clotilde, Ile de La Réunion, France. Electronic address:

Flaviviruses replicate in membranous factories associated with the endoplasmic reticulum (ER). Significant levels of flavivirus polyprotein integration contribute to ER stress and the host cell may exhibit an Unfolded Protein Response (UPR) to this protein accumulation, stimulating appropriate cellular responses such as adaptation, autophagy or cell death. These different stress responses support other antiviral strategies initiated by infected cells and can help to overcome viral infection. Read More

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http://dx.doi.org/10.1016/j.biochi.2020.05.011DOI Listing

Yellow Fever Vaccine Safety Perception of Pregnant Women in Emergency Response Mass Vaccination in Uganda.

Am J Trop Med Hyg 2020 Jul 21;103(1):160-163. Epub 2020 May 21.

Department of Social and Preventive Medicine, Unit Medical Anthropology and Global Health, Center for Public Health, Medical University of Vienna, Vienna, Austria.

Yellow fever vaccine, a live attenuated vaccine, is primarily administered to pregnant women during outbreaks. A qualitative study was conducted in pregnant women on the perception of yellow fever mass vaccination. In total, interviews with 20 women-13 semi-structured interviews and one focus group discussion with seven participants-were analyzed. Read More

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http://dx.doi.org/10.4269/ajtmh.19-0439DOI Listing

Dengue Virus and Yellow Fever Virus Detection Using Reverse Transcription-Insulated Isothermal PCR and Comparison with Real-Time RT-PCR.

Am J Trop Med Hyg 2020 Jul 21;103(1):157-159. Epub 2020 May 21.

Department of Global Health, Rollins School of Public Health, Atlanta, Georgia.

Real-time reverse transcriptase PCR (rRT-PCR) is the most accurate method for the detection of dengue virus (DENV) and yellow fever virus (YFV) in acute illness. However, performing rRT-PCR is not feasible for many laboratories in regions of endemicity. The current study compared new reverse transcription-insulated isothermal PCRs (the POCKIT DENV and YFV reagent sets) with laboratory-developed rRT-PCRs for both viruses using clinical samples and viral strains from different endemic regions. Read More

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http://dx.doi.org/10.4269/ajtmh.19-0892DOI Listing

The V1016G mutation of the voltage-gated sodium channel (VGSC) gene contributes to the insecticide resistance of Aedes aegypti from Makassar, Indonesia.

Parasitol Res 2020 Jul 26;119(7):2075-2083. Epub 2020 May 26.

Institute of Parasitology, Biomedical Research Centre Seltersberg (BFS), Justus Liebig University Giessen, Schubertstr. 81,, 35392, Giessen, Germany.

Aedes aegypti represents one of the main vectors of at least five relevant arthropod-borne viral infections in humans (i.e., Rift Valley fever, Dengue fever, Zika, chikungunya, and yellow fever) worldwide. Read More

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http://dx.doi.org/10.1007/s00436-020-06720-5DOI Listing