1,105 results match your criteria Yaws


Prioritizing surveillance activities for certification of yaws eradication based on a review and model of historical case reporting.

PLoS Negl Trop Dis 2018 Dec 4;12(12):e0006953. Epub 2018 Dec 4.

Institute of Tropical Medicine, Antwerp, Belgium.

Background: The World Health Organization (WHO) has targeted yaws for global eradication. Eradication requires certification that all countries are yaws-free. While only 14 Member States currently report cases to WHO, many more are known to have a history of yaws and some of them may have ongoing transmission. Read More

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December 2018
3 Reads

Integrated Management of Skin NTDs-Lessons Learned from Existing Practice and Field Research.

Authors:
Rie R Yotsu

Trop Med Infect Dis 2018 Nov 14;3(4). Epub 2018 Nov 14.

School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki 852-8102, Japan.

Integration of neglected tropical diseases (NTDs) into the public health agenda has been a priority in global health for the last decade. Because a number of these diseases share not only the geographical distribution, but also a common feature which is skin involvement, bringing together a sub-group of 'skin NTDs' is one way forward to promote further integration among NTDs. With these diseases, which include leprosy, Buruli ulcer, yaws, mycetoma, lymphatic filariasis, and leishmaniasis, patients may be left with life-long deformities and disabilities when diagnosis and treatment are delayed. Read More

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November 2018
1 Read

First Paleogenetic Evidence of Probable Syphilis and Treponematoses Cases in the Brazilian Colonial Period.

Biomed Res Int 2018 10;2018:8304129. Epub 2018 Oct 10.

Laboratório de Biologia de Tripanosomatídeos (LABTRIP), Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Av. Brasil, 4365 - Manguinhos, Rio de Janeiro, RJ 21040-900, Brazil.

Despite interest in the origins of syphilis, paleopathological analysis has not provided answers, and paleogenetic diagnosis remains a challenge. Even venereal syphilis has low infectivity which means there are few circulating bacteria for most of the individual's life. Human remains recovered from the Nossa Senhora do Carmo Church (17th to 19th centuries) and the Praça XV Cemetery (18th to 19th centuries), Rio de Janeiro, Brazil, were subjected to paleogenetic analysis. Read More

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October 2018
2 Reads

Spatial-temporal clustering analysis of yaws on Lihir Island, Papua New Guinea to enhance planning and implementation of eradication programs.

PLoS Negl Trop Dis 2018 Oct 29;12(10):e0006840. Epub 2018 Oct 29.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.

Background: In the global program for the eradication of yaws, assessments of the prevalence of the disease are used to decide where to initiate mass treatment. However, the smallest administrative unit that should be used as the basis for making decisions is not clear. We investigated spatial and temporal clustering of yaws to help inform the choice of implementation unit. Read More

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October 2018

Simple leg ulcers: difficult diagnosis.

Trop Doct 2018 Oct 15:49475518804703. Epub 2018 Oct 15.

2 Paediatric Officer (Honorary), Vila Central Hospital, Port Vila, Vanuatu.

Chronic leg ulcers in children in tropical developing countries are common. They are difficult to diagnose clinically and to manage. Our case illustrates that even in areas where yaws is endemic and point of care testing is available, the diagnosis remains difficult. Read More

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October 2018
5 Reads

Complete genome sequences of two strains of Treponema pallidum subsp. pertenue from Indonesia: Modular structure of several treponemal genes.

PLoS Negl Trop Dis 2018 Oct 10;12(10):e0006867. Epub 2018 Oct 10.

Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

Background: Treponema pallidum subsp. pertenue (TPE) is the causative agent of yaws, a multistage disease endemic in tropical regions in Africa, Asia, Oceania, and South America. To date, seven TPE strains have been completely sequenced and analyzed including five TPE strains of human origin (CDC-2, CDC 2575, Gauthier, Ghana-051, and Samoa D) and two TPE strains isolated from the baboons (Fribourg-Blanc and LMNP-1). Read More

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October 2018
2 Reads

Advances in the Treatment of Yaws.

Authors:
Michael Marks

Trop Med Infect Dis 2018 Aug 29;3(3). Epub 2018 Aug 29.

Clinical Research Department, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK.

Yaws is one of the three endemic treponematoses and is recognised by the World Health Organization as a neglected tropical disease. Yaws is currently reported in 15 countries in the Pacific, South-East Asia, West and Central Africa, predominantly affects children, and results in destructive lesions of the skin and soft tissues. For most of the twentieth century penicillin-based treatment was the standard of care and resistance to penicillin has still not been described. Read More

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August 2018
3 Reads

Molecular strain typing of the yaws pathogen, Treponema pallidum subspecies pertenue.

PLoS One 2018 12;13(9):e0203632. Epub 2018 Sep 12.

Laboratory Reference and Research Branch, Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.

Yaws is a neglected tropical disease caused by the bacterium Treponema pallidum subspecies pertenue. The disease primarily affects children under 15 years of age living in low socioeconomic conditions in tropical areas. As a result of a renewed focus on the disease owing to a recent eradication effort initiated by the World Health Organization, we have evaluated a typing method, adapted from and based on the enhanced Centers for Disease Control and Prevention typing method for T. Read More

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September 2018
4 Reads

Modelling the spatial distribution of aquatic insects (Order Hemiptera) potentially involved in the transmission of Mycobacterium ulcerans in Africa.

Parasit Vectors 2018 Sep 6;11(1):501. Epub 2018 Sep 6.

Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.

Background: Biting aquatic insects belonging to the order Hemiptera have been suggested as potential vectors of Mycobacterium ulcerans in endemic areas for Buruli ulcer (BU). If this is the case, these insects would be expected to co-exist with M. ulcerans in the same geographical areas. Read More

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September 2018
3 Reads

A second chance.

Authors:
Martin Enserink

Science 2018 Jul;361(6399):216-221

Lihir Island in Papua New Guinea.

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July 2018
1 Read

Population-wide administration of single dose rifampicin for leprosy prevention in isolated communities: a three year follow-up feasibility study in Indonesia.

BMC Infect Dis 2018 Jul 11;18(1):324. Epub 2018 Jul 11.

Department of Public Health, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000, CA, Rotterdam, The Netherlands.

Background: Indonesia ranking third in the world, regarding leprosy burden. Chemoprophylaxis is effective in reducing risk of developing leprosy among contacts. 'Blanket approach' is an operational strategy for leprosy post-exposure prophylaxis in which all members of an isolated community, high endemic for leprosy are screened and given a single dose of rifampicin (SDR) in the absence of signs and symptoms of leprosy. Read More

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July 2018
2 Reads

Integrated approach in the control and management of skin neglected tropical diseases in Lalo, Benin.

PLoS Negl Trop Dis 2018 06 25;12(6):e0006584. Epub 2018 Jun 25.

Department of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland.

Background: Neglected Tropical Diseases (NTDs) are a group of several communicable diseases prevalent in the tropical and subtropical areas. The co-endemicity of these diseases, the similarity of the clinical signs, and need to maximize limited financial and human resources have necessitated implementation of integrated approach. Our study aims to share the lessons of this integrated approach in the fight against Buruli ulcer (BU), leprosy and yaws in a rural district in Benin. Read More

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June 2018
9 Reads
1 Citation

Historic Treponema pallidum genomes from Colonial Mexico retrieved from archaeological remains.

PLoS Negl Trop Dis 2018 06 21;12(6):e0006447. Epub 2018 Jun 21.

Institute for Archaeological Sciences, University of Tübingen, Tübingen, Germany.

Treponema pallidum infections occur worldwide causing, among other diseases, syphilis and yaws. In particular sexually transmitted syphilis is regarded as a re-emerging infectious disease with millions of new infections annually. Here we present three historic T. Read More

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June 2018
3 Reads

Aetiological Characterization of the Cutaneous Ulcer Syndrome in Papua New Guinea using Shotgun Metagenomics.

Clin Infect Dis 2018 Jun 16. Epub 2018 Jun 16.

Lihir Medical Center - International SOS, Newcrest Mining, Lihir Island, Papua New Guinea.

Background: Treponema pallidum subsp. pertenue and Haemophilus ducreyi are causative agents of cutaneous ulcer (CU) in yaws endemic regions in the tropics. However, a significant proportion of CU patients remain PCR-negative for both bacterial agents. Read More

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June 2018
9 Reads

Widespread Treponema pallidum Infection in Nonhuman Primates, Tanzania.

Emerg Infect Dis 2018 06;24(6):1002-1009

We investigated Treponema pallidum infection in 8 nonhuman primate species (289 animals) in Tanzania during 2015-2017. We used a serologic treponemal test to detect antibodies against the bacterium. Infection was further confirmed from tissue samples of skin-ulcerated animals by 3 independent PCRs (polA, tp47, and TP_0619). Read More

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June 2018
12 Reads

Skin disease prevalence study in schoolchildren in rural Côte d'Ivoire: Implications for integration of neglected skin diseases (skin NTDs).

PLoS Negl Trop Dis 2018 05 17;12(5):e0006489. Epub 2018 May 17.

Global Buruli Ulcer Initiative, World Health Organization, Geneva, Switzerland.

Background: Early detection of several skin-related neglected tropical diseases (skin NTDs)-including leprosy, Buruli ulcer, yaws, and scabies- may be achieved through school surveys, but such an approach has seldom been tested systematically on a large scale in endemic countries. Additionally, a better understanding of the spectrum of skin diseases and the at-risk populations to be encountered during such surveys is necessary to facilitate the process.

Methods: We performed a school skin survey for selected NTDs and the spectrum of skin diseases, among primary schoolchildren aged 5 to 15 in Côte d'Ivoire, West Africa. Read More

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May 2018
6 Reads

Point-of-care tests for syphilis and yaws in a low-income setting - A qualitative study of healthcare worker and patient experiences.

PLoS Negl Trop Dis 2018 04 19;12(4):e0006360. Epub 2018 Apr 19.

Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London, United Kingdom.

Introduction: The human treponematoses comprise venereal syphilis and the three non-venereal or endemic treponematoses yaws, bejel, and pinta. Serological assays remain the most common diagnostic method for all treponemal infections. Point-of-care tests (POCTs) for syphilis and yaws allow testing without further development of infrastructure in populations where routine laboratory facilities are not available. Read More

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April 2018
9 Reads

Gene target selection for loop-mediated isothermal amplification for rapid discrimination of Treponema pallidum subspecies.

PLoS Negl Trop Dis 2018 04 12;12(4):e0006396. Epub 2018 Apr 12.

Mast Diagnostica GmbH, Reinfeld, Germany.

We show proof of concept for gene targets (polA, tprL, and TP_0619) that can be used in loop-mediated isothermal amplification (LAMP) assays to rapidly differentiate infection with any of the three Treponema pallidum subspecies (pallidum (TPA), pertenue (TPE), and endemicum (TEN)) and which are known to infect humans and nonhuman primates (NHPs). Four TPA, six human, and two NHP TPE strains, as well as two human TEN strains were used to establish and validate the LAMP assays. All three LAMP assays were highly specific for the target DNA. Read More

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Genetics of human and animal uncultivable treponemal pathogens.

Infect Genet Evol 2018 Jul 22;61:92-107. Epub 2018 Mar 22.

Work Group Neglected Tropical Diseases, Pathology Unit, German Primate Center, Leibniz Institute for Primate Research, Kellnerweg 4, 37077 Göttingen, Germany,. Electronic address:

Treponema pallidum is an uncultivable bacterium and the causative agent of syphilis (subsp. pallidum [TPA]), human yaws (subsp. pertenue [TPE]), and bejel (subsp. Read More

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July 2018
2 Reads

Community-based mass treatment with azithromycin for the elimination of yaws in Ghana-Results of a pilot study.

PLoS Negl Trop Dis 2018 03 22;12(3):e0006303. Epub 2018 Mar 22.

Center for Global Health, Centers of Disease Control and Prevention, Atlanta, Georgia, United States of America.

Introduction: The WHO yaws eradication strategy consists of one round of total community treatment (TCT) of single-dose azithromycin with coverage of > 90%.The efficacy of the strategy to reduce the levels on infection has been demonstrated previously in isolated island communities in the Pacific region. We aimed to determine the efficacy of a single round of TCT with azithromycin to achieve a decrease in yaws prevalence in communities that are endemic for yaws and surrounded by other yaws-endemic areas. Read More

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March 2018
19 Reads

Direct Whole-Genome Sequencing of Cutaneous Strains of Haemophilus ducreyi.

Emerg Infect Dis 2018 04;24(4):786-789

Haemophilus ducreyi, which causes chancroid, has emerged as a cause of pediatric skin disease. Isolation of H. ducreyi in low-income settings is challenging, limiting phylogenetic investigation. Read More

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April 2018
7 Reads

Correction: Prevalence of Active and Latent Yaws in the Solomon Islands 18 Months after Azithromycin Mass Drug Administration for Trachoma.

Authors:

PLoS Negl Trop Dis 2018 03 7;12(3):e0006308. Epub 2018 Mar 7.

[This corrects the article DOI: 10.1371/journal.pntd. Read More

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March 2018
3 Reads

Low-dose versus standard-dose azithromycin for treatment of yaws.

Lancet Glob Health 2018 04 16;6(4):e357-e358. Epub 2018 Feb 16.

Department of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.

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April 2018
1 Read

Comparative efficacy of low-dose versus standard-dose azithromycin for patients with yaws: a randomised non-inferiority trial in Ghana and Papua New Guinea.

Lancet Glob Health 2018 04 16;6(4):e401-e410. Epub 2018 Feb 16.

Department of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland.

Background: A dose of 30 mg/kg of azithromycin is recommended for treatment of yaws, a disease targeted for global eradication. Treatment with 20 mg/kg of azithromycin is recommended for the elimination of trachoma as a public health problem. In some settings, these diseases are co-endemic. Read More

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April 2018
16 Reads
2 Citations

Community knowledge, perceptions and attitudes regarding leprosy in rural Cameroon: The case of Ekondotiti and Mbonge health districts in the South-west Region.

PLoS Negl Trop Dis 2018 02 12;12(2):e0006233. Epub 2018 Feb 12.

Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, The University of Yaounde 1, Yaounde, Cameroon.

Background: Although leprosy is one of the oldest diseases known to humanity, it remains largely misunderstood. Misconceptions about leprosy lead to stigma towards people with the disease. This study aimed at exploring the knowledge, perceptions and attitudes regarding leprosy in rural Cameroon. Read More

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February 2018
18 Reads

Macrolide resistance in yaws.

Lancet 2018 04 7;391(10130):1555-1556. Epub 2018 Feb 7.

Department of Biology, Faculty of Medicine, Masaryk University in Brno, Brno CZ-625 00, Czech Republic.

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Re-emergence of yaws after single mass azithromycin treatment followed by targeted treatment: a longitudinal study.

Lancet 2018 04 7;391(10130):1599-1607. Epub 2018 Feb 7.

Department of Medicine, University of Washington, Seattle, WA, USA; Department of Global Health, University of Washington, Seattle, WA, USA.

Background: Yaws is a substantial cause of chronic disfiguring ulcers in children in at least 14 countries in the tropics. WHO's newly adopted strategy for yaws eradication uses a single round of mass azithromycin treatment followed by targeted treatment programmes, and data from pilot studies have shown a short-term significant reduction of yaws. We assessed the long-term efficacy of the WHO strategy for yaws eradication. Read More

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April 2018
9 Reads
45.217 Impact Factor

An imperial laboratory: the investigation and treatment of treponematoses in occupied Haiti, 1915-1934.

Hist Cienc Saude Manguinhos 2017 Oct-Dec;24(4):1089-1106

PhD Candidat, Newcastle University. School of History, Classics and Archaeology/Newcastle University. NE1 7RU - Newcastle-upon-Tyne - Reino Unido.

This article examines anti-treponematoses work as part of US occupation public health policy in Haiti, a unique event in the history of international health. Yaws was highly prevalent in Haiti, but occupation doctors initially ignored it because of its close association with syphilis and stigmas attached to sexually transmitted disease. This changed when C. Read More

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August 2018
1 Read

Active principles of Tetradenia riparia. IV. Anthelmintic activity of 8(14),15-sandaracopimaradiene-7α,18-diol.

J Ethnopharmacol 2018 Apr 31;216:229-232. Epub 2018 Jan 31.

Department of Biology, Animal Physiology and Neurobiology Section, KU Leuven, Naamsestraat 59, box 2465, 3000 Leuven, Belgium.

Ethnopharmacological Relevance: Tetradenia (T.) riparia (Hochst.) Codd (Lamiaceae), formerly known as Iboza riparia (Hochst. Read More

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April 2018
33 Reads

Development of a Multilocus Sequence Typing (MLST) scheme for Treponema pallidum subsp. pertenue: Application to yaws in Lihir Island, Papua New Guinea.

PLoS Negl Trop Dis 2017 12 27;11(12):e0006113. Epub 2017 Dec 27.

Department of Medicine, University of Washington, Seattle, Washington, United States of America.

Background: Yaws is a neglected tropical disease, caused by Treponema pallidum subsp. pertenue. The disease causes chronic lesions, primarily in young children living in remote villages in tropical climates. Read More

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December 2017
7 Reads

Targeted Treatment of Yaws With Household Contact Tracing: How Much Do We Miss?

Am J Epidemiol 2018 Apr;187(4):837-844

Mathematics Institute, University of Warwick, Coventry, United Kingdom.

Yaws is a disabling bacterial infection found primarily in warm and humid tropical areas. The World Health Organization strategy mandates an initial round of total community treatment (TCT) with single-dose azithromycin followed either by further TCT or active case-finding and treatment of cases and their contacts (the Morges strategy). We sought to investigate the effectiveness of the Morges strategy. Read More

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April 2018
11 Reads

Patent landscape of neglected tropical diseases: an analysis of worldwide patent families.

Global Health 2017 Nov 14;13(1):82. Epub 2017 Nov 14.

Department of Preventive Medicine, Faculty of Public Health, University of Debrecen, Debrecen, Hungary.

Background: "Neglected Tropical Diseases" (NTDs) affect millions of people in Africa, Asia and South America. The two primary ways of strategic interventions are "preventive chemotherapy and transmission control" (PCT), and "innovative and intensified disease management" (IDM). In the last 5 years, phenomenal progress has been achieved. Read More

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November 2017
31 Reads
2.250 Impact Factor

Single-dose azithromycin to treat latent yaws.

Lancet Glob Health 2017 12 26;5(12):e1172-e1173. Epub 2017 Oct 26.

Clinical Research Department, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.

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December 2017
14 Reads

Effectiveness of single-dose azithromycin to treat latent yaws: a longitudinal comparative cohort study.

Lancet Glob Health 2017 12 26;5(12):e1268-e1274. Epub 2017 Oct 26.

Barcelona Institute for Global Health, Hospital Clinic-University of Barcelona, Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain; Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique; Paediatric Infectious Diseases Unit, Paediatric Department, Hospital Sant Joan de Déu Barcelona, Barcelona, Spain.

Background: Treatment of latent yaws is a crucial component of the WHO yaws eradication strategy to prevent relapse and the resulting transmission to uninfected children. We assessed the effectiveness of single-dose azithromycin to treat patients with latent yaws.

Methods: This population-based cohort study included children (age <20 years) living on Lihir Island, Papua New Guinea, with high-titre (rapid plasma reagin titre ≥1:8) latent or active yaws, between April, 2013, and May, 2015. Read More

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December 2017
28 Reads

The cost and cost-effectiveness of rapid testing strategies for yaws diagnosis and surveillance.

PLoS Negl Trop Dis 2017 Oct 26;11(10):e0005985. Epub 2017 Oct 26.

Unit of General Epidemiology and Disease Control, Institute of Tropical Medicine, Antwerp, Belgium.

Background: Yaws is a non-venereal treponemal infection caused by Treponema pallidum subspecies pertenue. The disease is targeted by WHO for eradication by 2020. Rapid diagnostic tests (RDTs) are envisaged for confirmation of clinical cases during treatment campaigns and for certification of the interruption of transmission. Read More

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October 2017
8 Reads

Diagnostics for Yaws Eradication: Insights From Direct Next-Generation Sequencing of Cutaneous Strains of Treponema pallidum.

Clin Infect Dis 2018 Mar;66(6):818-824

Wellcome Trust Sanger Centre, Cambridge, United Kingdom.

Background: Yaws-like chronic ulcers can be caused by Treponema pallidum subspecies pertenue, Haemophilus ducreyi, or other, still-undefined bacteria. To permit accurate evaluation of yaws elimination efforts, programmatic use of molecular diagnostics is required. The accuracy and sensitivity of current tools remain unclear because our understanding of T. Read More

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March 2018
13 Reads

Single-Dose Azithromycin for the Treatment of Haemophilus ducreyi Skin Ulcers in Papua New Guinea.

Clin Infect Dis 2017 Nov;65(12):2085-2090

Barcelona Institute for Global Health, Hospital Clinic, University of Barcelona, Spain.

Background: Haemophilus ducreyi (HD) and Treponema pallidum subspecies pertenue (TP) are major causative agents of cutaneous ulcer (CU) in the tropics. Azithromycin is recommended to treat sexually transmitted HD infections and has good in vitro activity against HD strains from both genital and skin ulcers. We investigated the efficacy of oral single-dose azithromycin on HD-CU. Read More

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November 2017
15 Reads
8.886 Impact Factor

The cost-effectiveness of an eradication programme in the end game: Evidence from guinea worm disease.

PLoS Negl Trop Dis 2017 Oct 5;11(10):e0005922. Epub 2017 Oct 5.

Department of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland.

Background: Of the three diseases targeted for eradication by WHO, two are so-called Neglected Tropical Diseases (NTDs)-guinea worm disease (GWD) and yaws. The Guinea Worm Eradication Programme (GWEP) is in its final stages, with only 25 reported in 2016. However, global eradication still requires certification by WHO of the absence of transmission in all countries. Read More

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October 2017
10 Reads

Complete genome sequences of two strains of Treponema pallidum subsp. pertenue from Ghana, Africa: Identical genome sequences in samples isolated more than 7 years apart.

PLoS Negl Trop Dis 2017 Sep 8;11(9):e0005894. Epub 2017 Sep 8.

Department of Biology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno, Czech Republic.

Background: Treponema pallidum subsp. pertenue (TPE) is the causative agent of yaws, a multi-stage disease, endemic in tropical regions of Africa, Asia, Oceania, and South America. To date, four TPE strains have been completely sequenced including three TPE strains of human origin (Samoa D, CDC-2, and Gauthier) and one TPE strain (Fribourg-Blanc) isolated from a baboon. Read More

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September 2017
16 Reads

Knowledge, attitudes and practices towards yaws and yaws-like skin disease in Ghana.

PLoS Negl Trop Dis 2017 Jul 31;11(7):e0005820. Epub 2017 Jul 31.

School of Public Health, College of Health Sciences, University of Ghana, Legon, Ghana.

Introduction: Yaws is endemic in Ghana. The World Health Organization (WHO) has launched a new global eradication campaign based on total community mass treatment with azithromycin. Achieving high coverage of mass treatment will be fundamental to the success of this new strategy; coverage is dependent, in part, on appropriate community mobilisation. Read More

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July 2017
20 Reads

Bone lesions in yaws - another potential marker of indigenous Australian remains.

Authors:
Roger W Byard

Forensic Sci Med Pathol 2017 12 11;13(4):522-524. Epub 2017 Jul 11.

Adelaide Medical School, The University of Adelaide, Level 3 Medical School North Building, Frome Road, Adelaide,, 5005, Australia.

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December 2017
6 Reads

Haemophilus ducreyi DNA is detectable on the skin of asymptomatic children, flies and fomites in villages of Papua New Guinea.

PLoS Negl Trop Dis 2017 May 10;11(5):e0004958. Epub 2017 May 10.

Lihir Medical Centre- International SOS, Newcrest Mining, Lihir Island, Papua New Guinea.

Background: Haemophilus ducreyi and Treponema pallidum subsp. pertenue are major causes of leg ulcers in children in Africa and the Pacific Region. We investigated the presence of DNA (PCR positivity) from these bacteria on asymptomatic people, flies, and household linens in an endemic setting. Read More

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May 2017
30 Reads

Yaws resurgence in Bankim, Cameroon: The relative effectiveness of different means of detection in rural communities.

PLoS Negl Trop Dis 2017 May 8;11(5):e0005557. Epub 2017 May 8.

School of Anthropology, University of Arizona, Tucson, Arizona, United States of America.

Background: Yaws is an infectious, debilitating and disfiguring disease of poverty that mainly affects children in rural communities in tropical areas. In Cameroon, mass-treatment campaigns carried out in the 1950s reduced yaws to such low levels that it was presumed the disease was eradicated. In 2010, an epidemiological study in Bankim Health District detected 29 cases of yaws. Read More

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May 2017
10 Reads

Survey of Treponemal Infections in Free-Ranging and Captive Macaques, 1999-2012.

Emerg Infect Dis 2017 05;23(5):816-819

Survey results showed treponemal infection among pet macaques in Southeast Asia, a region with a high prevalence of human yaws. This finding, along with studies showing treponemal infection in nonhuman primates in Africa, should encourage a One Health approach to yaws eradication and surveillance activities, possibly including monitoring of nonhuman primates in yaws-endemic regions. Read More

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May 2017
9 Reads

Human Treponema pallidum 11q/j isolate belongs to subsp. endemicum but contains two loci with a sequence in TP0548 and TP0488 similar to subsp. pertenue and subsp. pallidum, respectively.

PLoS Negl Trop Dis 2017 03 6;11(3):e0005434. Epub 2017 Mar 6.

Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

Background: Treponema pallidum subsp. endemicum (TEN) is the causative agent of endemic syphilis (bejel). An unusual human TEN 11q/j isolate was obtained from a syphilis-like primary genital lesion from a patient that returned to France from Pakistan. Read More

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March 2017
12 Reads

Yaws Osteoperiostitis Treated with Single-Dose Azithromycin.

Am J Trop Med Hyg 2017 May 13;96(5):1039-1041. Epub 2017 Feb 13.

Barcelona Institute for Global Health, Hospital Clínic, University of Barcelona, Barcelona, Spain.

AbstractThe etiologic agent of yaws, subsp. , causes a multistage infection transmitted by nonsexual contact with the exudates from active lesions. Bone lesions in the form of osteoperiostitis are common and occur in numerous bones simultaneously in early stages. Read More

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May 2017
9 Reads

Functional clues from the crystal structure of an orphan periplasmic ligand-binding protein from Treponema pallidum.

Protein Sci 2017 04 23;26(4):847-856. Epub 2017 Mar 23.

Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390.

The spirochete Treponema pallidum is the causative agent of syphilis, a sexually transmitted infection of major global importance. Other closely related subspecies of Treponema also are the etiological agents of the endemic treponematoses, such as yaws, pinta, and bejel. The inability of T. Read More

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April 2017
14 Reads