1,111 results match your criteria Yaws


Neglected tropical diseases: elimination and eradication.

Clin Med (Lond) 2019 Mar;19(2):157-160

London School of Hygiene and Tropical Medicine, London, UK.

The term neglected tropical diseases (NTDs) describes a disparate group of diseases which affect populations living in poverty and are important causes of morbidity and mortality worldwide. Global programmes for the control of NTDs benefit large-scale donations made by pharmaceutical companies. A number of NTDs have internationally agreed targets for their control, elimination and eradication. Read More

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http://dx.doi.org/10.7861/clinmedicine.19-2-157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454364PMC

Epidemiological situation of yaws in the Americas: A systematic review in the context of a regional elimination goal.

PLoS Negl Trop Dis 2019 02 25;13(2):e0007125. Epub 2019 Feb 25.

Independent consultant, Madrid, Spain.

Background: Yaws is targeted for eradication by 2020 in the WHA66.12 resolution of the World Health Assembly. The objective of this study was to describe the occurrence of yaws in the Americas and to contribute to the compilation of evidence based on published data to undertake the certification of yaws eradication. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405159PMC
February 2019
2 Reads

Absence of Serological Evidence of Exposure to among Children Suggests Yaws Is No Longer Endemic in Kiribati.

Am J Trop Med Hyg 2019 Apr;100(4):940-942

Clinical Research Department, London School of Hygiene & Tropical Medicine, London, United Kingdom.

Yaws is a neglected tropical disease targeted for eradication by 2020. Kiribati, a Pacific Island nation, was previously endemic for yaws but lacks recent data from which its current endemicity status could be determined. This study tested antibody responses to to determine if transmission of yaws is taking place among children in Kiribati. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447131PMC
April 2019
1 Read

Topical treatment with gallium maltolate reduces Treponema pallidum subsp. pertenue burden in primary experimental lesions in a rabbit model of yaws.

PLoS Negl Trop Dis 2019 01 2;13(1):e0007076. Epub 2019 Jan 2.

Innovation to End Neglected Diseases (IT-ENDs), East Palo Alto, CA, United States of America.

Background: Gallium is a semi-metallic element known since the 1930s to have antimicrobial activity. This activity stems primarily from gallium's ability to mimic trivalent iron and disrupt specific Fe(III)-dependent pathways, particularly DNA synthesis (due to inhibition of ribonucleotide reductase). Because of its novel mechanism of action, gallium is currently being investigated as a new antibacterial agent, particularly in light of the increasing resistance of many pathogenic bacteria to existing antibiotics. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331133PMC
January 2019
2 Reads

Prioritizing surveillance activities for certification of yaws eradication based on a review and model of historical case reporting.

PLoS Negl Trop Dis 2018 12 4;12(12):e0006953. Epub 2018 Dec 4.

Institute of Tropical Medicine, Antwerp, Belgium.

Background: The World Health Organization (WHO) has targeted yaws for global eradication. Eradication requires certification that all countries are yaws-free. While only 14 Member States currently report cases to WHO, many more are known to have a history of yaws and some of them may have ongoing transmission. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294396PMC
December 2018
16 Reads

Integrated Management of Skin NTDs-Lessons Learned from Existing Practice and Field Research.

Authors:
Rie R Yotsu

Trop Med Infect Dis 2018 Nov 14;3(4). Epub 2018 Nov 14.

School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki 852-8102, Japan.

Integration of neglected tropical diseases (NTDs) into the public health agenda has been a priority in global health for the last decade. Because a number of these diseases share not only the geographical distribution, but also a common feature which is skin involvement, bringing together a sub-group of 'skin NTDs' is one way forward to promote further integration among NTDs. With these diseases, which include leprosy, Buruli ulcer, yaws, mycetoma, lymphatic filariasis, and leishmaniasis, patients may be left with life-long deformities and disabilities when diagnosis and treatment are delayed. Read More

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http://dx.doi.org/10.3390/tropicalmed3040120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306929PMC
November 2018
2 Reads

First Paleogenetic Evidence of Probable Syphilis and Treponematoses Cases in the Brazilian Colonial Period.

Biomed Res Int 2018 10;2018:8304129. Epub 2018 Oct 10.

Laboratório de Biologia de Tripanosomatídeos (LABTRIP), Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Av. Brasil, 4365 - Manguinhos, Rio de Janeiro, RJ 21040-900, Brazil.

Despite interest in the origins of syphilis, paleopathological analysis has not provided answers, and paleogenetic diagnosis remains a challenge. Even venereal syphilis has low infectivity which means there are few circulating bacteria for most of the individual's life. Human remains recovered from the Nossa Senhora do Carmo Church (17th to 19th centuries) and the Praça XV Cemetery (18th to 19th centuries), Rio de Janeiro, Brazil, were subjected to paleogenetic analysis. Read More

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http://dx.doi.org/10.1155/2018/8304129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199871PMC
February 2019
2 Reads

Spatial-temporal clustering analysis of yaws on Lihir Island, Papua New Guinea to enhance planning and implementation of eradication programs.

PLoS Negl Trop Dis 2018 10 29;12(10):e0006840. Epub 2018 Oct 29.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.

Background: In the global program for the eradication of yaws, assessments of the prevalence of the disease are used to decide where to initiate mass treatment. However, the smallest administrative unit that should be used as the basis for making decisions is not clear. We investigated spatial and temporal clustering of yaws to help inform the choice of implementation unit. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224128PMC
October 2018
1 Read

Simple leg ulcers: difficult diagnosis.

Trop Doct 2019 Jan 15;49(1):44-45. Epub 2018 Oct 15.

2 Paediatric Officer (Honorary), Vila Central Hospital, Port Vila, Vanuatu.

Chronic leg ulcers in children in tropical developing countries are common. They are difficult to diagnose clinically and to manage. Our case illustrates that even in areas where yaws is endemic and point of care testing is available, the diagnosis remains difficult. Read More

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http://journals.sagepub.com/doi/10.1177/0049475518804703
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http://dx.doi.org/10.1177/0049475518804703DOI Listing
January 2019
7 Reads

Complete genome sequences of two strains of Treponema pallidum subsp. pertenue from Indonesia: Modular structure of several treponemal genes.

PLoS Negl Trop Dis 2018 10 10;12(10):e0006867. Epub 2018 Oct 10.

Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

Background: Treponema pallidum subsp. pertenue (TPE) is the causative agent of yaws, a multistage disease endemic in tropical regions in Africa, Asia, Oceania, and South America. To date, seven TPE strains have been completely sequenced and analyzed including five TPE strains of human origin (CDC-2, CDC 2575, Gauthier, Ghana-051, and Samoa D) and two TPE strains isolated from the baboons (Fribourg-Blanc and LMNP-1). Read More

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http://dx.plos.org/10.1371/journal.pntd.0006867
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http://dx.doi.org/10.1371/journal.pntd.0006867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197692PMC
October 2018
3 Reads

Advances in the Treatment of Yaws.

Authors:
Michael Marks

Trop Med Infect Dis 2018 Aug 29;3(3). Epub 2018 Aug 29.

Clinical Research Department, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK.

Yaws is one of the three endemic treponematoses and is recognised by the World Health Organization as a neglected tropical disease. Yaws is currently reported in 15 countries in the Pacific, South-East Asia, West and Central Africa, predominantly affects children, and results in destructive lesions of the skin and soft tissues. For most of the twentieth century penicillin-based treatment was the standard of care and resistance to penicillin has still not been described. Read More

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http://www.mdpi.com/2414-6366/3/3/92
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http://dx.doi.org/10.3390/tropicalmed3030092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161241PMC
August 2018
3 Reads

Molecular strain typing of the yaws pathogen, Treponema pallidum subspecies pertenue.

PLoS One 2018 12;13(9):e0203632. Epub 2018 Sep 12.

Laboratory Reference and Research Branch, Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.

Yaws is a neglected tropical disease caused by the bacterium Treponema pallidum subspecies pertenue. The disease primarily affects children under 15 years of age living in low socioeconomic conditions in tropical areas. As a result of a renewed focus on the disease owing to a recent eradication effort initiated by the World Health Organization, we have evaluated a typing method, adapted from and based on the enhanced Centers for Disease Control and Prevention typing method for T. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203632PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135492PMC
February 2019
6 Reads

Modelling the spatial distribution of aquatic insects (Order Hemiptera) potentially involved in the transmission of Mycobacterium ulcerans in Africa.

Parasit Vectors 2018 Sep 6;11(1):501. Epub 2018 Sep 6.

Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.

Background: Biting aquatic insects belonging to the order Hemiptera have been suggested as potential vectors of Mycobacterium ulcerans in endemic areas for Buruli ulcer (BU). If this is the case, these insects would be expected to co-exist with M. ulcerans in the same geographical areas. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13071-018-3066-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127916PMC
September 2018
6 Reads

A second chance.

Authors:
Martin Enserink

Science 2018 Jul;361(6399):216-221

Lihir Island in Papua New Guinea.

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http://dx.doi.org/10.1126/science.361.6399.216DOI Listing
July 2018
1 Read

Population-wide administration of single dose rifampicin for leprosy prevention in isolated communities: a three year follow-up feasibility study in Indonesia.

BMC Infect Dis 2018 Jul 11;18(1):324. Epub 2018 Jul 11.

Department of Public Health, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000, CA, Rotterdam, The Netherlands.

Background: Indonesia ranking third in the world, regarding leprosy burden. Chemoprophylaxis is effective in reducing risk of developing leprosy among contacts. 'Blanket approach' is an operational strategy for leprosy post-exposure prophylaxis in which all members of an isolated community, high endemic for leprosy are screened and given a single dose of rifampicin (SDR) in the absence of signs and symptoms of leprosy. Read More

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http://dx.doi.org/10.1186/s12879-018-3233-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042242PMC
July 2018
3 Reads

Integrated approach in the control and management of skin neglected tropical diseases in Lalo, Benin.

PLoS Negl Trop Dis 2018 06 25;12(6):e0006584. Epub 2018 Jun 25.

Department of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland.

Background: Neglected Tropical Diseases (NTDs) are a group of several communicable diseases prevalent in the tropical and subtropical areas. The co-endemicity of these diseases, the similarity of the clinical signs, and need to maximize limited financial and human resources have necessitated implementation of integrated approach. Our study aims to share the lessons of this integrated approach in the fight against Buruli ulcer (BU), leprosy and yaws in a rural district in Benin. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034899PMC
June 2018
23 Reads
1 Citation

Historic Treponema pallidum genomes from Colonial Mexico retrieved from archaeological remains.

PLoS Negl Trop Dis 2018 06 21;12(6):e0006447. Epub 2018 Jun 21.

Institute for Archaeological Sciences, University of Tübingen, Tübingen, Germany.

Treponema pallidum infections occur worldwide causing, among other diseases, syphilis and yaws. In particular sexually transmitted syphilis is regarded as a re-emerging infectious disease with millions of new infections annually. Here we present three historic T. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013024PMC
June 2018
5 Reads

Etiological Characterization of the Cutaneous Ulcer Syndrome in Papua New Guinea Using Shotgun Metagenomics.

Clin Infect Dis 2019 Jan;68(3):482-489

Barcelona Institute for Global Health, Hospital Clínic-University of Barcelona, Spain.

Background: Treponema pallidum subsp pertenue and Haemophilus ducreyi are causative agents of cutaneous ulcer (CU) in yaws-endemic regions in the tropics. However, a significant proportion of CU patients remain polymerase chain reaction (PCR) negative for both bacterial agents. We aimed to identify potential additional etiological agents of CU in a yaws-endemic region. Read More

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http://dx.doi.org/10.1093/cid/ciy502DOI Listing
January 2019
13 Reads

Widespread Treponema pallidum Infection in Nonhuman Primates, Tanzania.

Emerg Infect Dis 2018 06;24(6):1002-1009

We investigated Treponema pallidum infection in 8 nonhuman primate species (289 animals) in Tanzania during 2015-2017. We used a serologic treponemal test to detect antibodies against the bacterium. Infection was further confirmed from tissue samples of skin-ulcerated animals by 3 independent PCRs (polA, tp47, and TP_0619). Read More

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http://dx.doi.org/10.3201/eid2406.180037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004850PMC
June 2018
19 Reads

Skin disease prevalence study in schoolchildren in rural Côte d'Ivoire: Implications for integration of neglected skin diseases (skin NTDs).

PLoS Negl Trop Dis 2018 05 17;12(5):e0006489. Epub 2018 May 17.

Global Buruli Ulcer Initiative, World Health Organization, Geneva, Switzerland.

Background: Early detection of several skin-related neglected tropical diseases (skin NTDs)-including leprosy, Buruli ulcer, yaws, and scabies- may be achieved through school surveys, but such an approach has seldom been tested systematically on a large scale in endemic countries. Additionally, a better understanding of the spectrum of skin diseases and the at-risk populations to be encountered during such surveys is necessary to facilitate the process.

Methods: We performed a school skin survey for selected NTDs and the spectrum of skin diseases, among primary schoolchildren aged 5 to 15 in Côte d'Ivoire, West Africa. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976208PMC
May 2018
11 Reads

Yaws Eradication Requires Improved Approach.

Authors:
M J Friedrich

JAMA 2018 Apr;319(15):1539

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http://dx.doi.org/10.1001/jama.2018.4126DOI Listing
April 2018
1 Read

Point-of-care tests for syphilis and yaws in a low-income setting - A qualitative study of healthcare worker and patient experiences.

PLoS Negl Trop Dis 2018 04 19;12(4):e0006360. Epub 2018 Apr 19.

Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London, United Kingdom.

Introduction: The human treponematoses comprise venereal syphilis and the three non-venereal or endemic treponematoses yaws, bejel, and pinta. Serological assays remain the most common diagnostic method for all treponemal infections. Point-of-care tests (POCTs) for syphilis and yaws allow testing without further development of infrastructure in populations where routine laboratory facilities are not available. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908063PMC
April 2018
20 Reads

Gene target selection for loop-mediated isothermal amplification for rapid discrimination of Treponema pallidum subspecies.

PLoS Negl Trop Dis 2018 04 12;12(4):e0006396. Epub 2018 Apr 12.

Mast Diagnostica GmbH, Reinfeld, Germany.

We show proof of concept for gene targets (polA, tprL, and TP_0619) that can be used in loop-mediated isothermal amplification (LAMP) assays to rapidly differentiate infection with any of the three Treponema pallidum subspecies (pallidum (TPA), pertenue (TPE), and endemicum (TEN)) and which are known to infect humans and nonhuman primates (NHPs). Four TPA, six human, and two NHP TPE strains, as well as two human TEN strains were used to establish and validate the LAMP assays. All three LAMP assays were highly specific for the target DNA. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978989PMC

Genetics of human and animal uncultivable treponemal pathogens.

Infect Genet Evol 2018 07 22;61:92-107. Epub 2018 Mar 22.

Work Group Neglected Tropical Diseases, Pathology Unit, German Primate Center, Leibniz Institute for Primate Research, Kellnerweg 4, 37077 Göttingen, Germany,. Electronic address:

Treponema pallidum is an uncultivable bacterium and the causative agent of syphilis (subsp. pallidum [TPA]), human yaws (subsp. pertenue [TPE]), and bejel (subsp. Read More

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http://dx.doi.org/10.1016/j.meegid.2018.03.015DOI Listing
July 2018
3 Reads

Community-based mass treatment with azithromycin for the elimination of yaws in Ghana-Results of a pilot study.

PLoS Negl Trop Dis 2018 03 22;12(3):e0006303. Epub 2018 Mar 22.

Center for Global Health, Centers of Disease Control and Prevention, Atlanta, Georgia, United States of America.

Introduction: The WHO yaws eradication strategy consists of one round of total community treatment (TCT) of single-dose azithromycin with coverage of > 90%.The efficacy of the strategy to reduce the levels on infection has been demonstrated previously in isolated island communities in the Pacific region. We aimed to determine the efficacy of a single round of TCT with azithromycin to achieve a decrease in yaws prevalence in communities that are endemic for yaws and surrounded by other yaws-endemic areas. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863939PMC
March 2018
31 Reads

Direct Whole-Genome Sequencing of Cutaneous Strains of Haemophilus ducreyi.

Emerg Infect Dis 2018 04;24(4):786-789

Haemophilus ducreyi, which causes chancroid, has emerged as a cause of pediatric skin disease. Isolation of H. ducreyi in low-income settings is challenging, limiting phylogenetic investigation. Read More

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http://dx.doi.org/10.3201/eid2404.171726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875288PMC
April 2018
13 Reads

Low-dose versus standard-dose azithromycin for treatment of yaws.

Lancet Glob Health 2018 04 16;6(4):e357-e358. Epub 2018 Feb 16.

Department of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.

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http://dx.doi.org/10.1016/S2214-109X(18)30067-6DOI Listing
April 2018
1 Read

Comparative efficacy of low-dose versus standard-dose azithromycin for patients with yaws: a randomised non-inferiority trial in Ghana and Papua New Guinea.

Lancet Glob Health 2018 04 16;6(4):e401-e410. Epub 2018 Feb 16.

Department of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland.

Background: A dose of 30 mg/kg of azithromycin is recommended for treatment of yaws, a disease targeted for global eradication. Treatment with 20 mg/kg of azithromycin is recommended for the elimination of trachoma as a public health problem. In some settings, these diseases are co-endemic. Read More

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http://dx.doi.org/10.1016/S2214-109X(18)30023-8DOI Listing
April 2018
25 Reads
2 Citations

Community knowledge, perceptions and attitudes regarding leprosy in rural Cameroon: The case of Ekondotiti and Mbonge health districts in the South-west Region.

PLoS Negl Trop Dis 2018 02 12;12(2):e0006233. Epub 2018 Feb 12.

Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, The University of Yaounde 1, Yaounde, Cameroon.

Background: Although leprosy is one of the oldest diseases known to humanity, it remains largely misunderstood. Misconceptions about leprosy lead to stigma towards people with the disease. This study aimed at exploring the knowledge, perceptions and attitudes regarding leprosy in rural Cameroon. Read More

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https://dx.plos.org/10.1371/journal.pntd.0006233
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http://dx.doi.org/10.1371/journal.pntd.0006233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825164PMC
February 2018
31 Reads

Macrolide resistance in yaws.

Lancet 2018 04 7;391(10130):1555-1556. Epub 2018 Feb 7.

Department of Biology, Faculty of Medicine, Masaryk University in Brno, Brno CZ-625 00, Czech Republic.

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http://dx.doi.org/10.1016/S0140-6736(18)30205-8DOI Listing

Re-emergence of yaws after single mass azithromycin treatment followed by targeted treatment: a longitudinal study.

Lancet 2018 04 7;391(10130):1599-1607. Epub 2018 Feb 7.

Department of Medicine, University of Washington, Seattle, WA, USA; Department of Global Health, University of Washington, Seattle, WA, USA.

Background: Yaws is a substantial cause of chronic disfiguring ulcers in children in at least 14 countries in the tropics. WHO's newly adopted strategy for yaws eradication uses a single round of mass azithromycin treatment followed by targeted treatment programmes, and data from pilot studies have shown a short-term significant reduction of yaws. We assessed the long-term efficacy of the WHO strategy for yaws eradication. Read More

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http://dx.doi.org/10.1016/S0140-6736(18)30204-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920722PMC
April 2018
20 Reads
45.217 Impact Factor

An imperial laboratory: the investigation and treatment of treponematoses in occupied Haiti, 1915-1934.

Hist Cienc Saude Manguinhos 2017 Oct-Dec;24(4):1089-1106

PhD Candidat, Newcastle University. School of History, Classics and Archaeology/Newcastle University. NE1 7RU - Newcastle-upon-Tyne - Reino Unido.

This article examines anti-treponematoses work as part of US occupation public health policy in Haiti, a unique event in the history of international health. Yaws was highly prevalent in Haiti, but occupation doctors initially ignored it because of its close association with syphilis and stigmas attached to sexually transmitted disease. This changed when C. Read More

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http://dx.doi.org/10.1590/S0104-59702017000500013DOI Listing
August 2018
1 Read

Active principles of Tetradenia riparia. IV. Anthelmintic activity of 8(14),15-sandaracopimaradiene-7α,18-diol.

J Ethnopharmacol 2018 Apr 31;216:229-232. Epub 2018 Jan 31.

Department of Biology, Animal Physiology and Neurobiology Section, KU Leuven, Naamsestraat 59, box 2465, 3000 Leuven, Belgium.

Ethnopharmacological Relevance: Tetradenia (T.) riparia (Hochst.) Codd (Lamiaceae), formerly known as Iboza riparia (Hochst. Read More

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http://dx.doi.org/10.1016/j.jep.2018.01.024DOI Listing
April 2018
44 Reads

Development of a Multilocus Sequence Typing (MLST) scheme for Treponema pallidum subsp. pertenue: Application to yaws in Lihir Island, Papua New Guinea.

PLoS Negl Trop Dis 2017 12 27;11(12):e0006113. Epub 2017 Dec 27.

Department of Medicine, University of Washington, Seattle, Washington, United States of America.

Background: Yaws is a neglected tropical disease, caused by Treponema pallidum subsp. pertenue. The disease causes chronic lesions, primarily in young children living in remote villages in tropical climates. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760108PMC
December 2017
10 Reads

Targeted Treatment of Yaws With Household Contact Tracing: How Much Do We Miss?

Am J Epidemiol 2018 Apr;187(4):837-844

Mathematics Institute, University of Warwick, Coventry, United Kingdom.

Yaws is a disabling bacterial infection found primarily in warm and humid tropical areas. The World Health Organization strategy mandates an initial round of total community treatment (TCT) with single-dose azithromycin followed either by further TCT or active case-finding and treatment of cases and their contacts (the Morges strategy). We sought to investigate the effectiveness of the Morges strategy. Read More

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http://dx.doi.org/10.1093/aje/kwx305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888927PMC
April 2018
11 Reads

Patent landscape of neglected tropical diseases: an analysis of worldwide patent families.

Global Health 2017 Nov 14;13(1):82. Epub 2017 Nov 14.

Department of Preventive Medicine, Faculty of Public Health, University of Debrecen, Debrecen, Hungary.

Background: "Neglected Tropical Diseases" (NTDs) affect millions of people in Africa, Asia and South America. The two primary ways of strategic interventions are "preventive chemotherapy and transmission control" (PCT), and "innovative and intensified disease management" (IDM). In the last 5 years, phenomenal progress has been achieved. Read More

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http://dx.doi.org/10.1186/s12992-017-0306-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686799PMC
November 2017
52 Reads
2.250 Impact Factor

Single-dose azithromycin to treat latent yaws.

Lancet Glob Health 2017 12 26;5(12):e1172-e1173. Epub 2017 Oct 26.

Clinical Research Department, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.

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http://dx.doi.org/10.1016/S2214-109X(17)30424-2DOI Listing
December 2017
14 Reads

Effectiveness of single-dose azithromycin to treat latent yaws: a longitudinal comparative cohort study.

Lancet Glob Health 2017 12 26;5(12):e1268-e1274. Epub 2017 Oct 26.

Barcelona Institute for Global Health, Hospital Clinic-University of Barcelona, Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain; Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique; Paediatric Infectious Diseases Unit, Paediatric Department, Hospital Sant Joan de Déu Barcelona, Barcelona, Spain.

Background: Treatment of latent yaws is a crucial component of the WHO yaws eradication strategy to prevent relapse and the resulting transmission to uninfected children. We assessed the effectiveness of single-dose azithromycin to treat patients with latent yaws.

Methods: This population-based cohort study included children (age <20 years) living on Lihir Island, Papua New Guinea, with high-titre (rapid plasma reagin titre ≥1:8) latent or active yaws, between April, 2013, and May, 2015. Read More

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http://dx.doi.org/10.1016/S2214-109X(17)30388-1DOI Listing
December 2017
34 Reads

The cost and cost-effectiveness of rapid testing strategies for yaws diagnosis and surveillance.

PLoS Negl Trop Dis 2017 Oct 26;11(10):e0005985. Epub 2017 Oct 26.

Unit of General Epidemiology and Disease Control, Institute of Tropical Medicine, Antwerp, Belgium.

Background: Yaws is a non-venereal treponemal infection caused by Treponema pallidum subspecies pertenue. The disease is targeted by WHO for eradication by 2020. Rapid diagnostic tests (RDTs) are envisaged for confirmation of clinical cases during treatment campaigns and for certification of the interruption of transmission. Read More

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http://dx.doi.org/10.1371/journal.pntd.0005985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658197PMC
October 2017
11 Reads

Diagnostics for Yaws Eradication: Insights From Direct Next-Generation Sequencing of Cutaneous Strains of Treponema pallidum.

Clin Infect Dis 2018 Mar;66(6):818-824

Wellcome Trust Sanger Centre, Cambridge, United Kingdom.

Background: Yaws-like chronic ulcers can be caused by Treponema pallidum subspecies pertenue, Haemophilus ducreyi, or other, still-undefined bacteria. To permit accurate evaluation of yaws elimination efforts, programmatic use of molecular diagnostics is required. The accuracy and sensitivity of current tools remain unclear because our understanding of T. Read More

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http://dx.doi.org/10.1093/cid/cix892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848336PMC
March 2018
21 Reads

Single-Dose Azithromycin for the Treatment of Haemophilus ducreyi Skin Ulcers in Papua New Guinea.

Clin Infect Dis 2017 Nov;65(12):2085-2090

Barcelona Institute for Global Health, Hospital Clinic, University of Barcelona, Spain.

Background: Haemophilus ducreyi (HD) and Treponema pallidum subspecies pertenue (TP) are major causative agents of cutaneous ulcer (CU) in the tropics. Azithromycin is recommended to treat sexually transmitted HD infections and has good in vitro activity against HD strains from both genital and skin ulcers. We investigated the efficacy of oral single-dose azithromycin on HD-CU. Read More

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http://dx.doi.org/10.1093/cid/cix723DOI Listing
November 2017
23 Reads
8.886 Impact Factor

The cost-effectiveness of an eradication programme in the end game: Evidence from guinea worm disease.

PLoS Negl Trop Dis 2017 Oct 5;11(10):e0005922. Epub 2017 Oct 5.

Department of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland.

Background: Of the three diseases targeted for eradication by WHO, two are so-called Neglected Tropical Diseases (NTDs)-guinea worm disease (GWD) and yaws. The Guinea Worm Eradication Programme (GWEP) is in its final stages, with only 25 reported in 2016. However, global eradication still requires certification by WHO of the absence of transmission in all countries. Read More

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http://dx.doi.org/10.1371/journal.pntd.0005922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628789PMC
October 2017
10 Reads

Complete genome sequences of two strains of Treponema pallidum subsp. pertenue from Ghana, Africa: Identical genome sequences in samples isolated more than 7 years apart.

PLoS Negl Trop Dis 2017 Sep 8;11(9):e0005894. Epub 2017 Sep 8.

Department of Biology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno, Czech Republic.

Background: Treponema pallidum subsp. pertenue (TPE) is the causative agent of yaws, a multi-stage disease, endemic in tropical regions of Africa, Asia, Oceania, and South America. To date, four TPE strains have been completely sequenced including three TPE strains of human origin (Samoa D, CDC-2, and Gauthier) and one TPE strain (Fribourg-Blanc) isolated from a baboon. Read More

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http://dx.doi.org/10.1371/journal.pntd.0005894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607219PMC
September 2017
24 Reads

Knowledge, attitudes and practices towards yaws and yaws-like skin disease in Ghana.

PLoS Negl Trop Dis 2017 Jul 31;11(7):e0005820. Epub 2017 Jul 31.

School of Public Health, College of Health Sciences, University of Ghana, Legon, Ghana.

Introduction: Yaws is endemic in Ghana. The World Health Organization (WHO) has launched a new global eradication campaign based on total community mass treatment with azithromycin. Achieving high coverage of mass treatment will be fundamental to the success of this new strategy; coverage is dependent, in part, on appropriate community mobilisation. Read More

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https://dx.plos.org/10.1371/journal.pntd.0005820
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http://dx.doi.org/10.1371/journal.pntd.0005820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552343PMC
July 2017
36 Reads

Bone lesions in yaws - another potential marker of indigenous Australian remains.

Authors:
Roger W Byard

Forensic Sci Med Pathol 2017 12 11;13(4):522-524. Epub 2017 Jul 11.

Adelaide Medical School, The University of Adelaide, Level 3 Medical School North Building, Frome Road, Adelaide,, 5005, Australia.

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http://dx.doi.org/10.1007/s12024-017-9898-xDOI Listing
December 2017
8 Reads

Haemophilus ducreyi DNA is detectable on the skin of asymptomatic children, flies and fomites in villages of Papua New Guinea.

PLoS Negl Trop Dis 2017 May 10;11(5):e0004958. Epub 2017 May 10.

Lihir Medical Centre- International SOS, Newcrest Mining, Lihir Island, Papua New Guinea.

Background: Haemophilus ducreyi and Treponema pallidum subsp. pertenue are major causes of leg ulcers in children in Africa and the Pacific Region. We investigated the presence of DNA (PCR positivity) from these bacteria on asymptomatic people, flies, and household linens in an endemic setting. Read More

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http://dx.doi.org/10.1371/journal.pntd.0004958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425006PMC
May 2017
53 Reads

Yaws resurgence in Bankim, Cameroon: The relative effectiveness of different means of detection in rural communities.

PLoS Negl Trop Dis 2017 May 8;11(5):e0005557. Epub 2017 May 8.

School of Anthropology, University of Arizona, Tucson, Arizona, United States of America.

Background: Yaws is an infectious, debilitating and disfiguring disease of poverty that mainly affects children in rural communities in tropical areas. In Cameroon, mass-treatment campaigns carried out in the 1950s reduced yaws to such low levels that it was presumed the disease was eradicated. In 2010, an epidemiological study in Bankim Health District detected 29 cases of yaws. Read More

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http://dx.doi.org/10.1371/journal.pntd.0005557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436870PMC
May 2017
11 Reads