1,086 results match your criteria Yaws
PLoS Negl Trop Dis 2018 06 21;12(6):e0006447. Epub 2018 Jun 21.
Institute for Archaeological Sciences, University of Tübingen, Tübingen, Germany.
Treponema pallidum infections occur worldwide causing, among other diseases, syphilis and yaws. In particular sexually transmitted syphilis is regarded as a re-emerging infectious disease with millions of new infections annually. Here we present three historic T. Read More
Clin Infect Dis 2018 Jun 16. Epub 2018 Jun 16.
Lihir Medical Center - International SOS, Newcrest Mining, Lihir Island, Papua New Guinea.
Background: Treponema pallidum subsp. pertenue and Haemophilus ducreyi are causative agents of cutaneous ulcer (CU) in yaws endemic regions in the tropics. However, a significant proportion of CU patients remain PCR-negative for both bacterial agents. Read More
Emerg Infect Dis 2018 Jun;24(6):1002-1009
We investigated Treponema pallidum infection in 8 nonhuman primate species (289 animals) in Tanzania during 2015-2017. We used a serologic treponemal test to detect antibodies against the bacterium. Infection was further confirmed from tissue samples of skin-ulcerated animals by 3 independent PCRs (polA, tp47, and TP_0619). Read More
PLoS Negl Trop Dis 2018 05 17;12(5):e0006489. Epub 2018 May 17.
Global Buruli Ulcer Initiative, World Health Organization, Geneva, Switzerland.
Background: Early detection of several skin-related neglected tropical diseases (skin NTDs)-including leprosy, Buruli ulcer, yaws, and scabies- may be achieved through school surveys, but such an approach has seldom been tested systematically on a large scale in endemic countries. Additionally, a better understanding of the spectrum of skin diseases and the at-risk populations to be encountered during such surveys is necessary to facilitate the process.
Methods: We performed a school skin survey for selected NTDs and the spectrum of skin diseases, among primary schoolchildren aged 5 to 15 in Côte d'Ivoire, West Africa. Read More
JAMA 2018 Apr;319(15):1539
PLoS Negl Trop Dis 2018 04 19;12(4):e0006360. Epub 2018 Apr 19.
Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London, United Kingdom.
Introduction: The human treponematoses comprise venereal syphilis and the three non-venereal or endemic treponematoses yaws, bejel, and pinta. Serological assays remain the most common diagnostic method for all treponemal infections. Point-of-care tests (POCTs) for syphilis and yaws allow testing without further development of infrastructure in populations where routine laboratory facilities are not available. Read More
PLoS Negl Trop Dis 2018 04 12;12(4):e0006396. Epub 2018 Apr 12.
Mast Diagnostica GmbH, Reinfeld, Germany.
We show proof of concept for gene targets (polA, tprL, and TP_0619) that can be used in loop-mediated isothermal amplification (LAMP) assays to rapidly differentiate infection with any of the three Treponema pallidum subspecies (pallidum (TPA), pertenue (TPE), and endemicum (TEN)) and which are known to infect humans and nonhuman primates (NHPs). Four TPA, six human, and two NHP TPE strains, as well as two human TEN strains were used to establish and validate the LAMP assays. All three LAMP assays were highly specific for the target DNA. Read More
Infect Genet Evol 2018 Jul 22;61:92-107. Epub 2018 Mar 22.
Work Group Neglected Tropical Diseases, Pathology Unit, German Primate Center, Leibniz Institute for Primate Research, Kellnerweg 4, 37077 Göttingen, Germany,. Electronic address:
Treponema pallidum is an uncultivable bacterium and the causative agent of syphilis (subsp. pallidum [TPA]), human yaws (subsp. pertenue [TPE]), and bejel (subsp. Read More
PLoS Negl Trop Dis 2018 03 22;12(3):e0006303. Epub 2018 Mar 22.
Center for Global Health, Centers of Disease Control and Prevention, Atlanta, Georgia, United States of America.
Introduction: The WHO yaws eradication strategy consists of one round of total community treatment (TCT) of single-dose azithromycin with coverage of > 90%.The efficacy of the strategy to reduce the levels on infection has been demonstrated previously in isolated island communities in the Pacific region. We aimed to determine the efficacy of a single round of TCT with azithromycin to achieve a decrease in yaws prevalence in communities that are endemic for yaws and surrounded by other yaws-endemic areas. Read More
Lancet Glob Health 2018 04 16;6(4):e357-e358. Epub 2018 Feb 16.
Department of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.
Lancet Glob Health 2018 04 16;6(4):e401-e410. Epub 2018 Feb 16.
Department of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland.
Background: A dose of 30 mg/kg of azithromycin is recommended for treatment of yaws, a disease targeted for global eradication. Treatment with 20 mg/kg of azithromycin is recommended for the elimination of trachoma as a public health problem. In some settings, these diseases are co-endemic. Read More
PLoS Negl Trop Dis 2018 02 12;12(2):e0006233. Epub 2018 Feb 12.
Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, The University of Yaounde 1, Yaounde, Cameroon.
Background: Although leprosy is one of the oldest diseases known to humanity, it remains largely misunderstood. Misconceptions about leprosy lead to stigma towards people with the disease. This study aimed at exploring the knowledge, perceptions and attitudes regarding leprosy in rural Cameroon. Read More
Lancet 2018 Apr 7;391(10130):1555-1556. Epub 2018 Feb 7.
Department of Biology, Faculty of Medicine, Masaryk University in Brno, Brno CZ-625 00, Czech Republic.
Lancet 2018 Apr 7;391(10130):1599-1607. Epub 2018 Feb 7.
Department of Medicine, University of Washington, Seattle, WA, USA; Department of Global Health, University of Washington, Seattle, WA, USA.
Background: Yaws is a substantial cause of chronic disfiguring ulcers in children in at least 14 countries in the tropics. WHO's newly adopted strategy for yaws eradication uses a single round of mass azithromycin treatment followed by targeted treatment programmes, and data from pilot studies have shown a short-term significant reduction of yaws. We assessed the long-term efficacy of the WHO strategy for yaws eradication. Read More
Hist Cienc Saude Manguinhos 2017 Oct-Dec;24(4):1089-1106
PhD Candidat, Newcastle University. School of History, Classics and Archaeology/Newcastle University. NE1 7RU - Newcastle-upon-Tyne - Reino Unido.
This article examines anti-treponematoses work as part of US occupation public health policy in Haiti, a unique event in the history of international health. Yaws was highly prevalent in Haiti, but occupation doctors initially ignored it because of its close association with syphilis and stigmas attached to sexually transmitted disease. This changed when C. Read More
J Ethnopharmacol 2018 Apr 31;216:229-232. Epub 2018 Jan 31.
Department of Biology, Animal Physiology and Neurobiology Section, KU Leuven, Naamsestraat 59, box 2465, 3000 Leuven, Belgium.
Ethnopharmacological Relevance: Tetradenia (T.) riparia (Hochst.) Codd (Lamiaceae), formerly known as Iboza riparia (Hochst. Read More
PLoS Negl Trop Dis 2017 12 27;11(12):e0006113. Epub 2017 Dec 27.
Department of Medicine, University of Washington, Seattle, Washington, United States of America.
Background: Yaws is a neglected tropical disease, caused by Treponema pallidum subsp. pertenue. The disease causes chronic lesions, primarily in young children living in remote villages in tropical climates. Read More
Am J Epidemiol 2018 Apr;187(4):837-844
Mathematics Institute, University of Warwick, Coventry, United Kingdom.
Yaws is a disabling bacterial infection found primarily in warm and humid tropical areas. The World Health Organization strategy mandates an initial round of total community treatment (TCT) with single-dose azithromycin followed either by further TCT or active case-finding and treatment of cases and their contacts (the Morges strategy). We sought to investigate the effectiveness of the Morges strategy. Read More
Global Health 2017 Nov 14;13(1):82. Epub 2017 Nov 14.
Department of Preventive Medicine, Faculty of Public Health, University of Debrecen, Debrecen, Hungary.
Background: "Neglected Tropical Diseases" (NTDs) affect millions of people in Africa, Asia and South America. The two primary ways of strategic interventions are "preventive chemotherapy and transmission control" (PCT), and "innovative and intensified disease management" (IDM). In the last 5 years, phenomenal progress has been achieved. Read More
Lancet Glob Health 2017 12 26;5(12):e1172-e1173. Epub 2017 Oct 26.
Clinical Research Department, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Lancet Glob Health 2017 12 26;5(12):e1268-e1274. Epub 2017 Oct 26.
Barcelona Institute for Global Health, Hospital Clinic-University of Barcelona, Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain; Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique; Paediatric Infectious Diseases Unit, Paediatric Department, Hospital Sant Joan de Déu Barcelona, Barcelona, Spain.
Background: Treatment of latent yaws is a crucial component of the WHO yaws eradication strategy to prevent relapse and the resulting transmission to uninfected children. We assessed the effectiveness of single-dose azithromycin to treat patients with latent yaws.
Methods: This population-based cohort study included children (age <20 years) living on Lihir Island, Papua New Guinea, with high-titre (rapid plasma reagin titre ≥1:8) latent or active yaws, between April, 2013, and May, 2015. Read More
PLoS Negl Trop Dis 2017 Oct 26;11(10):e0005985. Epub 2017 Oct 26.
Unit of General Epidemiology and Disease Control, Institute of Tropical Medicine, Antwerp, Belgium.
Background: Yaws is a non-venereal treponemal infection caused by Treponema pallidum subspecies pertenue. The disease is targeted by WHO for eradication by 2020. Rapid diagnostic tests (RDTs) are envisaged for confirmation of clinical cases during treatment campaigns and for certification of the interruption of transmission. Read More
Clin Infect Dis 2018 Mar;66(6):818-824
Wellcome Trust Sanger Centre, Cambridge, United Kingdom.
Background: Yaws-like chronic ulcers can be caused by Treponema pallidum subspecies pertenue, Haemophilus ducreyi, or other, still-undefined bacteria. To permit accurate evaluation of yaws elimination efforts, programmatic use of molecular diagnostics is required. The accuracy and sensitivity of current tools remain unclear because our understanding of T. Read More
Clin Infect Dis 2017 Nov;65(12):2085-2090
Barcelona Institute for Global Health, Hospital Clinic, University of Barcelona, Spain.
Background: Haemophilus ducreyi (HD) and Treponema pallidum subspecies pertenue (TP) are major causative agents of cutaneous ulcer (CU) in the tropics. Azithromycin is recommended to treat sexually transmitted HD infections and has good in vitro activity against HD strains from both genital and skin ulcers. We investigated the efficacy of oral single-dose azithromycin on HD-CU. Read More
PLoS Negl Trop Dis 2017 Oct 5;11(10):e0005922. Epub 2017 Oct 5.
Department of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland.
Background: Of the three diseases targeted for eradication by WHO, two are so-called Neglected Tropical Diseases (NTDs)-guinea worm disease (GWD) and yaws. The Guinea Worm Eradication Programme (GWEP) is in its final stages, with only 25 reported in 2016. However, global eradication still requires certification by WHO of the absence of transmission in all countries. Read More
PLoS Negl Trop Dis 2017 Sep 8;11(9):e0005894. Epub 2017 Sep 8.
Department of Biology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno, Czech Republic.
Background: Treponema pallidum subsp. pertenue (TPE) is the causative agent of yaws, a multi-stage disease, endemic in tropical regions of Africa, Asia, Oceania, and South America. To date, four TPE strains have been completely sequenced including three TPE strains of human origin (Samoa D, CDC-2, and Gauthier) and one TPE strain (Fribourg-Blanc) isolated from a baboon. Read More
PLoS Negl Trop Dis 2017 Jul 31;11(7):e0005820. Epub 2017 Jul 31.
School of Public Health, College of Health Sciences, University of Ghana, Legon, Ghana.
Introduction: Yaws is endemic in Ghana. The World Health Organization (WHO) has launched a new global eradication campaign based on total community mass treatment with azithromycin. Achieving high coverage of mass treatment will be fundamental to the success of this new strategy; coverage is dependent, in part, on appropriate community mobilisation. Read More
Forensic Sci Med Pathol 2017 12 11;13(4):522-524. Epub 2017 Jul 11.
Adelaide Medical School, The University of Adelaide, Level 3 Medical School North Building, Frome Road, Adelaide,, 5005, Australia.
PLoS Negl Trop Dis 2017 May 10;11(5):e0004958. Epub 2017 May 10.
Lihir Medical Centre- International SOS, Newcrest Mining, Lihir Island, Papua New Guinea.
Background: Haemophilus ducreyi and Treponema pallidum subsp. pertenue are major causes of leg ulcers in children in Africa and the Pacific Region. We investigated the presence of DNA (PCR positivity) from these bacteria on asymptomatic people, flies, and household linens in an endemic setting. Read More
PLoS Negl Trop Dis 2017 May 8;11(5):e0005557. Epub 2017 May 8.
School of Anthropology, University of Arizona, Tucson, Arizona, United States of America.
Background: Yaws is an infectious, debilitating and disfiguring disease of poverty that mainly affects children in rural communities in tropical areas. In Cameroon, mass-treatment campaigns carried out in the 1950s reduced yaws to such low levels that it was presumed the disease was eradicated. In 2010, an epidemiological study in Bankim Health District detected 29 cases of yaws. Read More
Emerg Infect Dis 2017 05;23(5):816-819
Survey results showed treponemal infection among pet macaques in Southeast Asia, a region with a high prevalence of human yaws. This finding, along with studies showing treponemal infection in nonhuman primates in Africa, should encourage a One Health approach to yaws eradication and surveillance activities, possibly including monitoring of nonhuman primates in yaws-endemic regions. Read More
PLoS Negl Trop Dis 2017 Mar 6;11(3):e0005434. Epub 2017 Mar 6.
Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Background: Treponema pallidum subsp. endemicum (TEN) is the causative agent of endemic syphilis (bejel). An unusual human TEN 11q/j isolate was obtained from a syphilis-like primary genital lesion from a patient that returned to France from Pakistan. Read More
Am J Trop Med Hyg 2017 May 13;96(5):1039-1041. Epub 2017 Feb 13.
Barcelona Institute for Global Health, Hospital Clínic, University of Barcelona, Barcelona, Spain.
AbstractThe etiologic agent of yaws, subsp. , causes a multistage infection transmitted by nonsexual contact with the exudates from active lesions. Bone lesions in the form of osteoperiostitis are common and occur in numerous bones simultaneously in early stages. Read More
Protein Sci 2017 Apr 23;26(4):847-856. Epub 2017 Mar 23.
Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390.
The spirochete Treponema pallidum is the causative agent of syphilis, a sexually transmitted infection of major global importance. Other closely related subspecies of Treponema also are the etiological agents of the endemic treponematoses, such as yaws, pinta, and bejel. The inability of T. Read More
PLoS Negl Trop Dis 2017 Jan 24;11(1):e0005267. Epub 2017 Jan 24.
Clinical Research Department, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Yaws and trachoma are targeted for eradication and elimination as public health problems. In trachoma-endemic populations mass administration of azithromycin can simultaneously treat yaws. We conducted a population-based prevalence survey in the five northernmost provinces of Vanuatu, where trachoma and yaws are suspected to be co-endemic. Read More
PLoS Negl Trop Dis 2017 01 19;11(1):e0005136. Epub 2017 Jan 19.
Department of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland.
Am J Trop Med Hyg 2017 Jan;96(1):3-4
Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
PLoS Negl Trop Dis 2017 Jan 10;11(1):e0005154. Epub 2017 Jan 10.
Department of Epidemiology, School of Public Health, University of Ghana, Legon, Ghana.
Background: Yaws is a treponemal infection that was almost eradicated fifty years ago; however, the disease has re-emerged in a number of countries including Ghana. A single-dose of intramuscular benzathine penicillin has been the mainstay of treatment for yaws. However, intramuscular injections are painful and pose safety and logistical constraints in the poor areas where yaws occurs. Read More
PLoS Negl Trop Dis 2016 Dec 27;10(12):e0005259. Epub 2016 Dec 27.
Departments of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.
Background: Haemophilus ducreyi has emerged as a major cause of cutaneous ulcers (CU) in yaws-endemic regions of the tropics in the South Pacific, South East Asia and Africa. H. ducreyi was once thought only to cause the genital ulcer (GU) disease chancroid; GU strains belong to 2 distinct classes, class I and class II. Read More
Emerg Infect Dis 2017 01;23(1):22-28
Yaws is targeted for eradication by 2020. The mainstay of the eradication strategy is mass treatment followed by case finding. Modeling has been used to inform programmatic requirements for other neglected tropical diseases and could provide insights into yaws eradication. Read More
BMC Infect Dis 2016 Dec 9;16(1):745. Epub 2016 Dec 9.
London School of Hygiene and Tropical Medicine, London, UK.
Background: Use of treponemal tests to screen for syphilis (caused by Treponema pallidum pallidum) poses challenges with infection status classification, especially in settings where other treponemal infections are endemic. This study aimed to determine the validity of the syphilis surveillance testing strategy implemented since 2004 using two treponemal tests, and estimate the seroprevalence of active syphilis infection in Ghana where yaws (caused by Treponema pallidum pertenue) is endemic.
Methods: We retested sera from the 2007 HIV sentinel survey (HSS) using a traditional algorithm, quantitative rapid plasma reagin test followed by qualitative Treponema pallidum haemagglutination assay. Read More
PLoS Negl Trop Dis 2016 Dec 5;10(12):e0005037. Epub 2016 Dec 5.
Background: Advocacy around mass treatment for the elimination of selected Neglected Tropical Diseases (NTDs) has typically put the cost per person treated at less than US$ 0.50. Whilst useful for advocacy, the focus on a single number misrepresents the complexity of delivering "free" donated medicines to about a billion people across the world. Read More
Trans R Soc Trop Med Hyg 2016 12 16;110(10):582-587. Epub 2016 Nov 16.
Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Background: Both yaws and trachoma are endemic in several countries in the Pacific. In co-endemic countries there may be potential synergies between both control programmes.
Methods: We undertook a cluster randomised trachoma and yaws seroprevalence survey of children in the Western Division of Fiji. Read More
Trends Parasitol 2016 11 13;32(11):843-854. Epub 2016 Sep 13.
Centre for International Child Health, University of Melbourne, Melbourne, Australia; Group A Streptococcal Research, Murdoch Childrens Research Institute, Melbourne, Australia.
Many neglected tropical diseases (NTDs) affect the skin, causing considerable disability, stigma, and exacerbation of poverty. However, there has been relatively little investment into laboratory research, epidemiology, diagnostic tools or management strategies to control tropical skin disease. Integration may advance the control of skin disease across a range of domains, including mapping, diagnosis, clinical management, and community control measures such as mass drug administration. Read More
PLoS Negl Trop Dis 2016 Oct 12;10(10):e0005012. Epub 2016 Oct 12.
Faculty of Medicine and Biomedical Sciences, The University of Yaounde 1, Yaounde, Cameroon.
Background: Cameroon achieved the elimination target of leprosy in 2000, and has maintained this status ever since. However, a number of health districts in the country continue to report significant numbers of leprosy cases. The aim of this study was to assess the burden of leprosy in Cameroon from 2000 to 2014. Read More
J Med Biogr 2016 Sep 28. Epub 2016 Sep 28.
Faculty of Medicine, University of British Columbia, Vancouver, Canada
When first described in 1958, Burkitt lymphoma was considered by many to be an African curiosity. However, over the next few decades, over 10,000 publications on Burkitt lymphoma would influence many facets of oncology research including immunology, molecular genetics, chemotherapy, and viral oncology. At the time of discovery, its distribution in equatorial Africa was unique; it was where a child was born and lived, and not what race they were, that conveyed the greatest incidence risk. Read More
JAMA 2016 Sep;316(11):1141
N Engl J Med 2016 09;375(11):1093-4
Canadian Forces Health Services Headquarters, Ottawa, ON, Canada