75,789 results match your criteria Wound Infection


Volume-Outcome Association of Mitral Valve Surgery in the United States.

JAMA Cardiol 2020 Jul 1. Epub 2020 Jul 1.

Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston.

Importance: Early surgery for severe primary degenerative mitral regurgitation is recommended, provided optimal outcomes are achievable. Contemporary national data defining mitral valve surgery volume and outcomes are lacking.

Objective: To assess national 30-day and 1-year outcomes of mitral valve surgery and define the hospital- and surgeon-level volume-outcome association with mitral valve repair or replacement (MVRR) in patients with primary mitral regurgitation. Read More

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http://dx.doi.org/10.1001/jamacardio.2020.2221DOI Listing

Negative pressure wound therapy in the treatment of surgical site infection in cardiac surgery.

Rev Bras Enferm 2020 1;73(5):e20190331. Epub 2020 Jul 1.

Universidade de São Paulo. São Paulo, São Paulo, Brazil.

Objectives: to describe the relationship between epidemiological and clinical characteristics of postoperative cardiac surgery patients undergoing negative pressure wound therapy for the treatment of surgical site infection.

Methods: an observational, cross-sectional analytical study including a convenience sample consisting of medical records of patients undergoing sternal cardiac surgery with surgical site infection diagnosed in medical records treated by negative pressure wound therapy.

Results: medical records of 117 patients, mainly submitted to myocardial revascularization surgery and with deep incisional surgical site infection (88; 75. Read More

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http://dx.doi.org/10.1590/0034-7167-2019-0331DOI Listing

Closing the Gap Toward Zero Tetanus Infection for Voluntary Medical Male Circumcision: Seven Case Reports and a Review of the Literature.

Surg Infect (Larchmt) 2020 Jun 30. Epub 2020 Jun 30.

Infectious Disease Institution, Makerere College of Health Sciences, Kampala, Uganda.

Voluntary medical male circumcision (VMMC) is important for HIV prevention, providing up to 60% protection. Although VMMC is usually a safe procedure, it is not free of associated serious adverse events. In the Uganda VMMC program, which is available to males 10 years of age and older, 11 individuals were reported with tetanus infection out of almost 3. Read More

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http://dx.doi.org/10.1089/sur.2020.103DOI Listing

Revision surgery and mortality following complex spine surgery: 2-year follow-up in a prospective cohort of 679 patients using the Spine AdVerse Event Severity (SAVES) system.

Spine Deform 2020 Jun 30. Epub 2020 Jun 30.

Department of Orthopedics and Scoliosis Surgery, Texas Children's Hospital and Baylor College of Medicine, 6621 Fannin St, Houston, TX, 77030, USA.

Study Design: Prospective study.

Objective: To determine the 2-year risk of revision surgery and all-cause mortality after complex spine surgery, and to assess if prospectively registered adverse events (AE) could predict either outcome. Revision surgery and mortality are serious complications to spine surgery. Read More

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http://dx.doi.org/10.1007/s43390-020-00164-8DOI Listing

antiviral host response to SARS-CoV-2 by viral load, sex, and age.

bioRxiv 2020 Jun 22. Epub 2020 Jun 22.

Despite limited genomic diversity, SARS-CoV-2 has shown a wide range of clinical manifestations in different patient populations. The mechanisms behind these host differences are still unclear. Here, we examined host response gene expression across infection status, viral load, age, and sex among shotgun RNA-sequencing profiles of nasopharyngeal swabs from 430 individuals with PCR-confirmed SARS-CoV-2 and 54 negative controls. Read More

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http://dx.doi.org/10.1101/2020.06.22.165225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325176PMC

Clinical outcomes of sacral neuromodulation in non-neurogenic, non-obstructive dysuria: A 5-year retrospective, multicentre study in China.

World J Clin Cases 2020 Jun;8(12):2494-2501

Department of Urology, West China Hospital, Sichuan University, Chengdu 610000, Sichuan Province, China.

Background: Management of non-neurogenic, non-obstructive dysuria represents one of the most challenging dilemmas in urological practice. The main clinical symptom is the increase in residual urine. Voiding dysfunction is the main cause of dysuria or urinary retention, mainly due to the decrease in bladder contraction (the decrease in contraction amplitude or duration) or the increase in outflow tract resistance. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i12.2494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322430PMC

Tornadic Shear Stress Induces a Transient, Calcineurin-Dependent Hypervirulent Phenotype in Mucorales Molds.

mBio 2020 Jun 30;11(3). Epub 2020 Jun 30.

Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA

Trauma-related necrotizing myocutaneous mucormycosis (NMM) has a high morbidity and mortality in victims of combat-related injuries, geometeorological disasters, and severe burns. Inspired by the observation that several recent clusters of NMM have been associated with extreme mechanical forces (e.g. Read More

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http://dx.doi.org/10.1128/mBio.01414-20DOI Listing

Surgical Decision-Making in Microvascular Reconstruction of Composite Scalp and Skull Defects.

J Craniofac Surg 2020 Jun 19. Epub 2020 Jun 19.

Department of Plastic Surgery, University of Kansas Medical Center, Kansas City, KS.

Objectives: Microvascular reconstruction of composite scalp and skull defects requires careful planning of both cranial bone and soft-tissue coverage. The current body of literature has yet to identify a "best practice" approach to achieve these goals.

Methods: A retrospective chart review was performed. Read More

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http://dx.doi.org/10.1097/SCS.0000000000006623DOI Listing

Microorganisms and Antibiogram Patterns in Fournier's Gangrene: Contemporary Experience from a Single Tertiary Care Center.

J Urol 2020 Jun 30:101097JU0000000000001194. Epub 2020 Jun 30.

The Ohio State University Wexner Medical Center, Department of Urology, Columbus, Ohio.

Purpose: To evaluate the prevalent microorganisms, antibiotic sensitivity patterns, and associated outcomes in patients with Fournier's Gangrene (FG).

Materials And Methods: A retrospective chart review of patients with FG was conducted between October 2011 and April 2018 at our institution. Univariate analysis was performed using independent t-test or Kruskal-Wallis H test for continuous variables and exact test for categorical variables. Read More

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http://dx.doi.org/10.1097/JU.0000000000001194DOI Listing

A woman in her sixties with a knee injury after a fall.

Tidsskr Nor Laegeforen 2020 Jun 29;140(10). Epub 2020 Jun 29.

Background: The diagnosis of necrotising soft tissue infections (NSTIs, necrotising fasciitis, myositis and cellulitis) may be clinically challenging, and can result in fatal outcomes.

Case Presentation: A previously healthy woman in her sixties fell and cut her right patella. The wound was complicated by localised infection, which subsequently developed into a bacterial bursitis. Read More

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http://dx.doi.org/10.4045/tidsskr.19.0694DOI Listing

Fingertip Injuries and Amputations: A Review of the Literature.

Cureus 2020 May 26;12(5):e8291. Epub 2020 May 26.

Plastic and Reconstructive Surgery, Northwestern University Feinberg School of Medicine, Chicago, USA.

The fingertip is defined as the part of the digit distal to the insertion of the extensor and flexor tendons on the distal phalanx. Devastating injuries to the hand occur every year that lead fingertip amputations in thousands of people. The highest incidence rates are usually seen in children less than five years old and in adults over the age of 65. Read More

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http://dx.doi.org/10.7759/cureus.8291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317129PMC

Closed Incision Negative Pressure Therapy Achieves Better Outcome Than Standard Wound Care: Clinical Outcome and Cost-Effectiveness Analysis in Open Ventral Hernia Repair With Synthetic Mesh Positioning.

Cureus 2020 May 26;12(5):e8283. Epub 2020 May 26.

Surgical, Oncological and Oral Sciences, Policlinico Universitario P. Giaccone, University of Palermo, Palermo, ITA.

Background Surgical site infections (SSIs) and surgical site occurrences (SSOs) are frequent post-operative complications that are dependent on the presence of different risk factors. The use of closed incision negative pressure therapy (ciNPT) is considered a measure by the WHO guidelines for prevention of SSIs. The prevention of SSOs is an extremely important issue in the ventral hernia repair (VHR) surgical field. Read More

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http://dx.doi.org/10.7759/cureus.8283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317132PMC

Effects of adding adjunctive hyperbaric oxygen therapy to standard wound care for diabetic foot ulcers: a protocol for a systematic review with meta-analysis and trial sequential analysis.

BMJ Open 2020 Jun 29;10(6):e031708. Epub 2020 Jun 29.

Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Copenhagen, Rigshospitalet, Denmark.

Introduction: Diabetic foot ulcer represents a major health problem globally. Preliminary studies have indicated that systemic treatment of diabetic foot ulcer patients with hyperbaric oxygen therapy have beneficial effects on wound healing, risk of amputation, glycaemic control, atherosclerosis, inflammatory markers and other clinical and laboratory parameters. This protocol for a systematic review aims at identifying the beneficial and harmful effects of adding hyperbaric oxygen therapy to standard wound care for diabetic foot ulcers. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-031708DOI Listing

Clinical risk factors and inflammatory biomarkers of post-traumatic acute kidney injury in combat patients.

Surgery 2020 Jun 27. Epub 2020 Jun 27.

Department of Surgery at the Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center, Bethesda, MD; Uniformed Services University Surgical Critical Care Initiative, Bethesda, MD. Electronic address:

Background: Post-traumatic acute kidney injury has occurred in every major military conflict since its initial description during World War II. To ensure the proper treatment of combat casualties, early detection is critical. This study therefore aimed to investigate combat-related post-traumatic acute kidney injury in recent military conflicts, used machine learning algorithms to identify clinical and biomarker variables associated with the development of post-traumatic acute kidney injury, and evaluated the effects of post-traumatic acute kidney injury on wound healing and nosocomial infection. Read More

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http://dx.doi.org/10.1016/j.surg.2020.04.064DOI Listing

Total Ankle Arthroplasty Survivorship: A Meta-analysis.

J Foot Ankle Surg 2020 Jun 26. Epub 2020 Jun 26.

Assistant Professor in Surgery, Department of Surgery, Harvard Medical School, Boston, MA; Chief, Division of Podiatric Surgery, Department of Surgery, Mount Auburn Hospital, Cambridge, MA.

The gold standard for management of end-stage ankle arthritis was previously ankle arthrodesis; however, improvements in total ankle replacements are making this a more viable treatment option. The primary aim of this meta-analysis was to evaluate the survivorship of total ankle replacement implants currently in use. An extensive search strategy initially captured 20,842 citations that were evaluated for relevance. Read More

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http://dx.doi.org/10.1053/j.jfas.2019.10.011DOI Listing

Negative pressure wound therapy versus conventional dressing for open fractures in lower extremity trauma.

Bone Joint J 2020 Jul;102-B(7):912-917

Department of Orthopaedics, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.

Aims: It has been generally accepted that open fractures require early skeletal stabilization and soft-tissue reconstruction. Traditionally, a standard gauze dressing was applied to open wounds. There has been a recent shift in this paradigm towards negative pressure wound therapy (NPWT). Read More

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http://dx.doi.org/10.1302/0301-620X.102B7.BJJ-2019-1462.R1DOI Listing

Addressing the challenges in antisepsis: focus on povidone iodine.

Int J Antimicrob Agents 2020 Jun 26:106064. Epub 2020 Jun 26.

Ghent University Hospital, Ghent, Belgium. Electronic address:

The use of antiseptics in wound care can promote healing by preventing and treating infection. However, using antiseptics can present many challenges, including issues with tolerability, inactivation by organic matter and the emergence of antimicrobial resistance/cross-resistance. In this article we will discuss the key challenges in antisepsis, focusing on the antiseptic povidone-iodine (PVP-I). Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2020.106064DOI Listing

TULUA Lipoabdominoplasty: No Supraumbilical Elevation Combined With Transverse Infraumbilical Plication, Video Description and Experience With 164 Patients.

Aesthet Surg J 2020 Jun 29. Epub 2020 Jun 29.

Plastic Surgery, Universidad del Valle, Cali, Colombia, and Unidad Central del Valle, Tuluá, Valle, Colombia.

Background: TULUA is a fundamentally different lipoabdominoplasty technique intended to reduce the risk of vascular compromise, correct wall laxity through a unique plication, allow freedom in choosing umbilical position, reduce tension on closure, and keep the final scar low.

Objectives: The objectives of this article were to describe the TULUA technique and its variations, delineate the indications and contraindications, show the expected results, and determine its safety profile.

Methods: A series of 164 patients is presented. Read More

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http://dx.doi.org/10.1093/asj/sjaa183DOI Listing

Comparative RNA-Seq analyses of Drosophila plasmatocytes reveal gene specific signatures in response to clean injury and septic injury.

PLoS One 2020 29;15(6):e0235294. Epub 2020 Jun 29.

Global Health Institute, School of Life Science, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

Drosophila melanogaster's blood cells (hemocytes) play essential roles in wound healing and are involved in clearing microbial infections. Here, we report the transcriptional changes of larval plasmatocytes after clean injury or infection with the Gram-negative bacterium Escherichia coli or the Gram-positive bacterium Staphylococcus aureus compared to hemocytes recovered from unchallenged larvae via RNA-Sequencing. This study reveals 676 differentially expressed genes (DEGs) in hemocytes from clean injury samples compared to unchallenged samples, and 235 and 184 DEGs in E. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235294PLOS

What Should be Done for Perforation of the Gallbladder During Laparoscopic Cholecystectomy: Prophylaxis or Treatment?

J Laparoendosc Adv Surg Tech A 2020 Jun 26. Epub 2020 Jun 26.

Department of General Surgery, Faculty of Medicine, Alanya Alaaddin Keykubat University, Alanya, Turkey.

Iatrogenic perforation of the gallbladder during laparoscopic cholecystectomy (LC) is one of the most common intraoperative complications, and there is no clear consensus among surgeons on this issue and there are studies reporting the antibiotic treatment. The aim of this study is to determine the effect of type and duration of antibiotic use on infective complications between iatrogenic perforations of the gallbladder during LC patients. Patients who developed iatrogenic perforation of gallbladder during LC were subdivided into three groups according to antibiotic treatment; single dose intravenous (i. Read More

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http://dx.doi.org/10.1089/lap.2020.0322DOI Listing

Bioresorbable, Wireless, Passive Sensors as Temporary Implants for Monitoring Regional Body Temperature.

Adv Healthc Mater 2020 Jun 29:e2000942. Epub 2020 Jun 29.

Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL, 60208, USA.

Measurements of regional internal body temperatures can yield important information in the diagnosis of immune response-related anomalies, for precisely managing the effects of hyperthermia and hypothermia therapies and monitoring other transient body processes such as those associated with wound healing. Current approaches rely on permanent implants that require extraction surgeries after the measurements are no longer needed. Emerging classes of bioresorbable sensors eliminate the requirements for extraction, but their use of percutaneous wires for data acquisition leads to risks for infection at the suture site. Read More

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http://dx.doi.org/10.1002/adhm.202000942DOI Listing

Global Hidradenitis Suppurativa COVID-19 Registry: A Registry to Inform Data-Driven Management Practices.

Br J Dermatol 2020 Jun 29. Epub 2020 Jun 29.

Patientforeningen HS, Copenhagen, Denmark.

The management of hidradenitis suppurativa (HS), a chronic inflammatory skin disease, deserves special consideration in the context of the Coronavirus 2019 (COVID-19) pandemic. A new Global Hidradenitis Suppurativa COVID-19 Registry has been developed to capture data on risks, clinical course, and outcomes of COVID-19 in HS patients. Caused by the virus SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2), COVID-19 is an easily transmissible disease which, in its most severe form, is characterized by respiratory failure and multiple organ dysfunction triggered by a cytokine storm response that predominates in older adults and those with significant comorbidities. Read More

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http://dx.doi.org/10.1111/bjd.19345DOI Listing

The feasibility and safety of early ileostomy reversal: a systematic review and meta-analysis.

ANZ J Surg 2020 Jun 28. Epub 2020 Jun 28.

Colorectal Unit, Department of General Surgery, St John of God Subiaco Hospital, Perth, Western Australia, Australia.

Background: Recent evidence supports the safety of early reversal of a temporary stoma, within 14 days of construction. The aim of this systematic review and meta-analysis was to evaluate the post-operative morbidity and overall feasibility of early stoma reversal.

Methods: Medline and Cochrane databases were searched for studies up to June 2019 that investigated the outcomes of early stoma reversal (EC, defined as closure ≤14 days from the index operation) versus late stoma reversal (LC, ≥8 weeks from the index operation). Read More

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http://dx.doi.org/10.1111/ans.16079DOI Listing

Securement to prevent device-related pressure injuries in the intensive care unit: A randomised controlled feasibility study.

Int Wound J 2020 Jun 28. Epub 2020 Jun 28.

School of Nursing, Queensland University of Technology, Brisbane, Australia.

Medical device-related pressure injuries are the most common cause of pressure injuries within the intensive care unit, in particular those caused by nasogastric tubes and endotracheal tubes. There are several known methods, which can alleviate the pressure of these devices on the skin surface to reduce the rate of these injuries. To determine the feasibility of conducting a larger, adequately powered trial testing, several clinically effective interventions to reduce the incidence of medical device-related pressure injuries caused by these devices. Read More

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http://dx.doi.org/10.1111/iwj.13432DOI Listing

Predicting length of stay in head and neck patients who undergo free flap reconstruction.

Laryngoscope Investig Otolaryngol 2020 Jun 28;5(3):461-467. Epub 2020 May 28.

Department of Otolaryngology Massachusetts Eye and Ear Infirmary Boston Massachusetts USA.

Objective: Understanding factors that affect postoperative length of stay (LOS) may improve patient recovery, hasten postoperative discharge, and minimize institutional costs. This study sought to (a) describe LOS among head and neck patients undergoing free flap reconstruction and (b) identify factors that predict increased LOS.

Methods: A retrospective cohort was performed of 282 head and neck patients with free flap reconstruction for oncologic resection between 2011 and 2013 at a tertiary academic medical center. Read More

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http://dx.doi.org/10.1002/lio2.410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314462PMC

Paraglottic and Pre-epiglottic Space Abscess in Adults: Report of Two Cases.

Iran J Otorhinolaryngol 2020 May;32(110):187-191

Department of Otolaryngology, "Attikon" University Hospital, Athens, Greece. Rimini 1, Chaidari, Athens 124 62, Greece.

Introduction: Acute epiglottitis or supraglottitis is a rapidly progressing upper respiratory tract infection that can often threaten the airway patency. Epiglottic abscess that expands to the paraglottic (PGS) or preepiglottic (PES) space and acute airway obstruction constitute rare complications, exclusively presented in adults.

Case Report: We report two cases. Read More

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http://dx.doi.org/10.22038/ijorl.2020.42184.2375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302529PMC

Factitious Disorder Presenting with Refractory Enterocutaneous Fistula that Underwent 7 Surgeries.

Case Rep Gastroenterol 2020 May-Aug;14(2):291-298. Epub 2020 May 27.

Department of Colorectal Disease, The No.10 People's Hospital of Shanghai, Shanghai, China.

The formation of a post-appendicectomy fistula is rare but devastating. Major etiological factors include leakage from the appendiceal stump, neoplasm of the appendix and/or cecum, infection, inflammatory bowel disease, and distal obstruction. The management of enterocutaneous fistula involves enteral nutrition, drainage, antibiotic coverage, as well as surgical excision and segmental resection of the involved bowel. Read More

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http://dx.doi.org/10.1159/000506936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315171PMC

Bacterial Profile, Antimicrobial Susceptibility Pattern, and Associated Risk Factors Among Patients With Wound Infections at Debre Markos Referral Hospital, Northwest, Ethiopia.

Int J Low Extrem Wounds 2020 Jun 28:1534734620933731. Epub 2020 Jun 28.

University of Gondar, Gondar, Ethiopia.

Wound infections are associated with morbidity and mortality in developing countries. Thus, this study aimed to assess bacterial profile, antimicrobial susceptibility pattern and risk factors among wound infection suspected patients. A hospital-based cross-sectional study was conducted on 201 participants at Debre Markos referral hospital from January to May 2019. Read More

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http://dx.doi.org/10.1177/1534734620933731DOI Listing

Curcumin Nanoparticles Improved Diabetic Wounds Infected With Methicillin-Resistant Sensitized With HAMLET.

Int J Low Extrem Wounds 2020 Jun 28:1534734620933079. Epub 2020 Jun 28.

Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Accurately orchestrated course of events normally observed in healing are not followed in diabetic wounds, and bacterial colonization/infection further messes up the process. Novel therapeutic options for treatment of infections caused by multidrug-resistant are urgently needed. HAMLET (human α-lactalbumin made lethal to tumor cells) has been reported to be able to sensitize bacterial pathogens to traditional antimicrobial agents. Read More

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http://dx.doi.org/10.1177/1534734620933079DOI Listing

Limb Salvage in Patients With Severe Critical Limb Ischemia (CLI) After Referral for a Second Opinion to a Dedicated CLI Center.

Int J Low Extrem Wounds 2020 Jun 28:1534734620933069. Epub 2020 Jun 28.

Athens Medical Center, Athens, Greece.

The complexity of critical limb ischemia (CLI) requires dedicated multidisciplinary teams of different care providers, who will supervise the full cycle of CLI care. Until CLI treatment is fully centralized, such dedicated teams may work as second-opinion tools before major amputation is undertaken in CLI patients. The aim of the study is to assess the effectiveness of a well-timed referral to a dedicated CLI-center of patients scheduled to major amputation elsewhere. Read More

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http://dx.doi.org/10.1177/1534734620933069DOI Listing

[One case of severely scalded patient with pneumonia and sepsis].

Zhonghua Shao Shang Za Zhi 2020 Jun;36(6):503-505

Pharmacological Research, Qingdao Municipal Hospital, Qingdao 266011, China.

In February 2018, one 54-year-old male patient with severe scald complicated with pneumonia and sepsis was transferred to Qingdao Municipal Hospital from other hospital. Drugs including cephalosporin, vancomycin, and imipenem/cilastatin combined with ciprofloxacin were used successively for anti-infective treatment, with no obvious effect. Multiple bacterial culture results of sputum, blood, and wound exudate showed infection of extensively drug resistant . Read More

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http://dx.doi.org/10.3760/cma.j.cn501120-20190221-00034DOI Listing

[Clinical application of self-made drainage tubes in different layers of soft tissue for negative-pressure wound therapy in 33 patients].

Zhonghua Shao Shang Za Zhi 2020 Jun;36(6):493-496

Department of Burns and Plastic Surgery, the Affiliated Jiangyin Hospital, Medical College of Southeast University, Jiangyin 214400, China.

From January 2014 to June 2018, 28 patients with different types of deep soft tissue injury or infection were admitted to the Affiliated Jiangyin Hospital of Medical College of Southeast University; 5 patients were admitted to the Zhengzhou First People's Hospital. There were 24 males and 9 females, aged 18-89 (40±20) years. Disposable suction tubes with holes cut on side walls were used as self-made drainage tubes. Read More

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http://dx.doi.org/10.3760/cma.j.cn501120-20190327-00142DOI Listing

[Clinical strategies for preservation of the exposed implant in chronic wounds and wound repair].

Zhonghua Shao Shang Za Zhi 2020 Jun;36(6):484-487

Department of Burns and Plastic Surgery, the Fourth Medical Center of PLA General Hospital, Beijing 100048, China.

To explore the clinical strategies for preservation of the exposed implant in chronic wounds and wound repair. From January 2016 to January 2019, totally 8 patients (4 males and 4 females, aged 10 to 73 years) sustaining postoperative chronic wounds with exposed implants were admitted to the Fourth Medical Center of PLA General Hospital. There were 2 cases of abdominal patch exposure after abdominal trauma surgery, 2 cases of titanium plate exposure post craniocerebral surgery, 3 cases of internal fixator exposure post orthopedic surgery, and 1 case of cerebrospinal fluid drainage tube exposure after craniocerebral surgery. Read More

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http://dx.doi.org/10.3760/cma.j.cn501120-20190215-00027DOI Listing

[Clinical effect of X-N advancement flap in repairing pressure ulcer on the buttock or back].

Zhonghua Shao Shang Za Zhi 2020 Jun;36(6):476-479

Department of Pathology, Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545005.

To explore the clinical effect of X-N advancement flap in repairing pressure ulcer on the buttock or back. From June 2018 to June 2019, 20 patients with grade Ⅳ pressure ulcers on the buttock or back were hospitalized and treated in the Department of Traumatology, Burns and Plastic Surgery of Fourth Affiliated Hospital of Guangxi Medical University, including 15 males and 5 females, aged 48-89 years. The area of the patient's wound was 8 cm×5 cm-15 cm×12 cm after debridement, and all were repaired with the X-N advancement flap designed by the author. Read More

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http://dx.doi.org/10.3760/cma.j.cn501120-20191011-00399DOI Listing

[Selection and effects of flap/myocutaneous flap repair methods for the defect after perineum tumor resection].

Zhonghua Shao Shang Za Zhi 2020 Jun;36(6):451-457

Department of Gynecologic Oncology, Hunan Cancer Hospital, Changsha 410008, China.

To explore the selection and effects of flap/myocutaneous flap repair methods for the defect after perineum tumor resection. From January 2011 to February 2017, 31 patients with vulvar tumor who were admitted to Hunan Cancer Hospital underwent repair of wound after tumor resection with various flaps/myocutaneous flaps. The patients were composed of 5 males and 26 females, aged 39-76 years, with 27 vulvar cancer and 4 Paget's disease in primary diseases. Read More

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http://dx.doi.org/10.3760/cma.j.cn501120-20190320-00129DOI Listing

[Effects of two dimensional gray-scale blood flow imaging combined with color Doppler flow imaging in guiding arterial puncture and catheterization through wounds in patients with large burns].

Zhonghua Shao Shang Za Zhi 2020 Jun;36(6):440-445

Department of Burn Surgery, the First Hospital of Jilin University, Changchun 130021, China.

To explore the effects of two dimensional gray-scale blood flow imaging (hereinafter referred to as " B-flow" ) combined with color Doppler flow imaging (CDFI) in guiding arterial puncture and catheterization through wounds in patients with large burns. Sixty-seven patients with large burns who met the inclusion criteria and hospitalized in the First Hospital of Jilin University from January 2017 to January 2019 were enrolled in the prospectively randomized control study. According to the random number table, CDFI alone group was allocated with 35 patients (23 males and 12 females) and B-flow+ CDFI group with 32 patients (22 males and 10 females), aged 19-60 and 18-58 years, respectively. Read More

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http://dx.doi.org/10.3760/cma.j.cn501120-20190309-00099DOI Listing

Incidence and risk factors of in-hospital prosthesis-related complications following total hip arthroplasty: a retrospective Nationwide Inpatient Sample database study.

Int Orthop 2020 Jun 27. Epub 2020 Jun 27.

Division of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue, Guangzhou, 510515, Guangdong, China.

Purpose: The occurrence of prosthesis-related complications (PRCs) after total hip arthroplasty (THA) is devastating, commonly meaning implant failure and revision surgery. The purpose was to examine the incidence and risk factors of in-hospital PRCs following THA using a large-scale national database.

Methods: A retrospective database analysis was performed based on Nationwide Inpatient Sample (NIS) from 2005 to 2014. Read More

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http://dx.doi.org/10.1007/s00264-020-04682-yDOI Listing

A Care Bundle Intervention to Prevent Surgical Site Infections after a Craniotomy.

Clin Infect Dis 2020 Jun 28. Epub 2020 Jun 28.

Infectious Diseases Department, Hospital Universitari de Bellvitge - Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain.

Background: Although surgical site infections after a craniotomy (SSI-CRAN) are a serious problem involving significant morbidity and costs, information on their prevention is scarce. We aimed to assess whether the implementation of a care bundle was effective in preventing SSI-CRANs.

Methods: A historical control study was used to evaluate the care bundle, which included a preoperative shower with 4% chlorhexidine soap, appropriate hair removal, adequate preoperative systemic antibiotic prophylaxis, the administration of 1 g of vancomycin powder into the subgaleal space before closing, and a post-operative dressing of the incisional surgical wound with a sterile absorbent cover. Read More

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http://dx.doi.org/10.1093/cid/ciaa884DOI Listing

Preoperative Nutritional Status Predicts Major Morbidity After Primary Rectal Cancer Resection.

J Surg Res 2020 Jun 25;255:325-331. Epub 2020 Jun 25.

Department of Surgery, Sinai Hospital of Baltimore, Baltimore, Maryland.

Background: Malnutrition has been associated with adverse surgical outcomes, but data regarding its impact specifically in rectal cancer are sparse. The goal of this study was to use national data to determine the effects of malnutrition on surgical outcomes in rectal cancer resection.

Methods: Data were obtained from the American College of Surgeons National Surgical Quality Initiative Program from the years 2012-2015. Read More

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http://dx.doi.org/10.1016/j.jss.2020.05.081DOI Listing

Healthcare-associated infections in burn patients: Timeline and risk factors.

Burns 2020 May 16. Epub 2020 May 16.

Burn Unit, Hospital Universitario del Valle, Universidad del Valle, Cali, Colombia.

Background: Healthcare-associated infections (HAIs) remain a major challenge in burn research and care. We aimed to describe the epidemiology and timeline of HAIs and to estimate the association of demographics and clinical characteristics with time to HAI among burn patients.

Methods: A prospective cohort study was conducted in a referral burn unit in southwestern Colombia. Read More

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http://dx.doi.org/10.1016/j.burns.2020.04.031DOI Listing

Hypothesis validation of rosiglitazone a potential inhibitor against glycogen synthase kinase-3β, for the management of multifaceted pathophysiology of the diabetic wound: An insilico study.

Med Hypotheses 2020 Jun 13;144:109990. Epub 2020 Jun 13.

Department of Pharmaceutics, Max Institute of Pharmaceutical Sciences, Khammam, Telangana 507318, India. Electronic address:

Diabetic wound (DW) is a major complication of diabetes mellitus that often ends up with amputation of the concerned organ. The current therapies for DW include glucose regulation, wound debridement, pressure off-loading, surgeries, hyperbaric oxygen therapy, maggot therapy, and so on. However, the majority are not meeting all the prerequisites of DW because of extensive pathology and cost associated with the strategies. Read More

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http://dx.doi.org/10.1016/j.mehy.2020.109990DOI Listing

Mandibular osteomyelitis after hyaluronic acid injection.

J Cosmet Dermatol 2020 Jun 27. Epub 2020 Jun 27.

Department of Plastic surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Background: Mandibular osteomyelitis after filler injection is extremely rare. We reported a case of mandibular osteomyelitis after hyaluronic acid injection.

Patients: A 33-year-old woman received 1ml hyaluronic acid injection on her chin one year ago, after which her chin kept swelling and painful, and gradually ulcerated with pus flowing out. Read More

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http://dx.doi.org/10.1111/jocd.13575DOI Listing

Idiopathic necrotizing fasciitis following fracture fixation: A case report.

Medicine (Baltimore) 2020 Jun;99(26):e20874

Department of Orthopaedics, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, Zhejiang Province.

Introduction: Idiopathic necrotizing fasciitis (NF) is an infrequent, highly lethal skin infection that spreads rapidly, marked by fascia and subcutaneous tissue necrosis. It occurs in the absence of a known causative factor. Its emergence after sterile orthopedic fixation with unexpected spread to the abdomen may turn to be challenging both as a medical and surgical emergency. Read More

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http://dx.doi.org/10.1097/MD.0000000000020874DOI Listing
June 2020
5.723 Impact Factor

Overview of Host Defense Peptides and Their Applications for Plastic and Reconstructive Surgeons.

Plast Reconstr Surg 2020 Jul;146(1):91-103

Los Angeles, Calif.; and Ann Arbor, Mich. From the Division of Plastic and Reconstructive Surgery, Department of Surgery, and the Department of Bioengineering, University of California, Los Angeles; and the Section of Plastic Surgery, Department of Surgery, University of Michigan.

Background: Host defense peptides are a family of endogenous short peptides that are found in all living beings and play a critical role in innate immunity against infection.

Methods: A nonsystematic review of host defense peptides was conducted with specific interest in properties and applications relevant to plastic and reconstructive surgery.

Results: In addition to their direct antimicrobial actions against pathogens, including multidrug-resistant bacteria, they also demonstrate important functions in immunomodulation, tumor cell lysis, and tissue regeneration. Read More

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http://dx.doi.org/10.1097/PRS.0000000000006910DOI Listing

Increased Rate of Complications following Trigger Finger Release in Diabetic Patients.

Plast Reconstr Surg 2020 Jun 22. Epub 2020 Jun 22.

Purpose: To investigate the impact of diabetes on complications after open trigger finger release (TFR) compared with an age, sex, race, and body mass index (BMI) class matched cohort.

Methods: A retrospective chart review was performed of diabetic patients who underwent TFR at an academic institution within the past 10 years. Exclusion criteria included rheumatoid arthritis, malignancy, HIV/AIDS, connective tissue disorders, or systemic steroid use. Read More

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http://dx.doi.org/10.1097/PRS.0000000000007156DOI Listing

Perioperative intensive glycaemic control for liver transplant recipients to prevent surgical site infection: A systematic review and meta-analysis.

Transpl Infect Dis 2020 Jun 26:e13390. Epub 2020 Jun 26.

The University of Nottingham, Faculty of Medicine & Health Sciences, The Queen's Medical Centre, Nottingham, NG7 2UH, United Kingdom.

Background: Surgical Site Infections (SSIs) are common among liver transplant recipients and result in adverse patient outcomes. Standard glycaemic control is effective in reducing SSIs. Some studies suggest intensive glycaemic control reduces the risk of SSI further. Read More

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http://dx.doi.org/10.1111/tid.13390DOI Listing

Wound Irrigation in Orthopedic Open Fractures: A Review.

Surg Infect (Larchmt) 2020 Jun 25. Epub 2020 Jun 25.

The Diane N. Weiss Center for Orthopaedic Trauma Research, Rhode Island Hospital, Providence, Rhode Island, USA.

Management of open fractures remains a major clinical challenge because of the higher energy involved in the injury, the greater local trauma, tissue necrosis, and extensive contamination. Even though early surgical debridement was thought to be critical, limited available operative techniques have minimized surgery in favor of early antibiotic administration. No clear agreement on the surgical approach, debridement, or irrigation technique exists. Read More

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http://dx.doi.org/10.1089/sur.2020.075DOI Listing

Agricultural Injury-Associated Infection in a Bangladeshi Farmer.

Am J Trop Med Hyg 2020 Jun 22. Epub 2020 Jun 22.

Laboratory Sciences and Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh.

is an emerging environmental pathogen that causes life-threatening infection in humans and animals. In October 2017, a Bangladeshi farmer was hospitalized with high-grade fever due to an agricultural injury-related wound infection. Bacteriological and 16S rRNA gene investigation detected in the wound discharge. Read More

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http://dx.doi.org/10.4269/ajtmh.20-0312DOI Listing

Plastic-Reconstructive Treatment Algorithm for Dead Space Management Following Septic Total Hip Arthroplasty Removal: AV Loop and Two-Stage Free Myocutaneous Latissimus Dorsi Flap.

Z Orthop Unfall 2020 Jun 25. Epub 2020 Jun 25.

University Centre for Orthopaedic and Trauma Surgery, Carl Gustav Carus University Hospital, Dresden.

Background: A 61-year-old patient presented with a right Girdlestone hip and wound dehiscence due to extensive dead space after radical debridement and septic arthroplasty removal. A two-stage reconstruction with the application of a subcutaneous autologous arterio-venous (AV) loop using an autologous vena saphena magna (VSM) interposition graft followed by a free latissimus dorsi flap was performed.

Method: We decided to perform a two-stage procedure with AV loop creation in the first step and free flap transplantation seven days after it. Read More

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http://dx.doi.org/10.1055/s-0037-1599649DOI Listing

Prophylactic negative pressure wound therapy for closed laparotomy wounds: a systematic review and meta-analysis of randomised controlled trials.

Ir J Med Sci 2020 Jun 25. Epub 2020 Jun 25.

Department of Colorectal Surgery, St James's Hospital, Dublin, 8, Ireland.

Surgical site infections are a common source of post-operative morbidity and contribute significantly to healthcare costs. Patients undergoing emergency laparotomy and/or bowel surgery are particularly at risk. Prophylactic negative pressure wound therapy (NPWT) has been shown to reduce wound infection. Read More

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http://dx.doi.org/10.1007/s11845-020-02283-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315908PMC