1,035,495 results match your criteria Wound Infection


A giant sacrococcygeal teratoma in adult female: A case report.

Int J Surg Case Rep 2018 Nov 22;54:47-50. Epub 2018 Nov 22.

Department of General Surgery, King Abdulla University Hospital, Faculty of Medicine, Jordan University of Science and Technology, P.O. Box (3030), Irbid, 22110, Jordan. Electronic address:

Introduction: Sacrococcygealteratoma is very rare in adults with only few cases reported in literature. It is a slow growing benign cystic tumor with 1-2% chance for malignant transformation and may attain a huge size causing pressure effect on pelvic and intra-abdominal organs. When grows caudally, it causes discomfort, skin excoriation and cosmetic disfigurement. Read More

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November 2018
3 Reads

Elaboration of a thermosensitive smart biomaterial: From synthesis to the ex vivo bioadhesion evaluation.

Colloids Surf B Biointerfaces 2018 Nov 30;175:91-97. Epub 2018 Nov 30.

CIRIMAT, Université de Toulouse 3 - Paul Sabatier, CNRS, Toulouse, France. Electronic address:

Alginate and chitosan are polysaccharides that are widely used in the biomedical field, especially as wound dressings. Controlled bioadhesion is an advanced functionality that offers the potential to reduce injuries due to the stripping-off of the biomaterial. Herein, we report the efficient grafting of poly-N(isopropylacryamide) (PNIPAM), a thermosensitive polymer that exhibits a lower critical solution temperature (LCST) at 32 °C on the alginate/chitosan polyelectrolyte complex (PEC) surface. Read More

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November 2018

Posterior Extensive Circumferential Decompressive Reconstructive Technique in surgical treatment of Upper Thoracic Spine Compressive Lesions.

World Neurosurg 2018 Dec 3. Epub 2018 Dec 3.

Department of Orthopedic Surgery and Traumatology and Minia University Hospital, Mohammed Badway str., 61111, El-Minia, Egypt; Minia University Spine Unit (MUSU), Faculty of Medicine, Minia University. Minia University Hospital, Mohammed Badway str., 61111, El-Minia, Egypt. Electronic address:

Background Data: Complexity in ventral surgical exposure, presence of scapula and large para-scapular musculature during posterior surgery are the main obstacles in operative treatment of Upper Thoracic Spine Compressive Lesions (UTSCL) like trauma, tuberculosis and neoplasm. Recently, the advantages of combined ventro-dorsal surgery could be successfully gained using 1-stage posterior salvage technique with enough accessibility to all three spinal columns.

Purpose: Retrospective evaluation of 35 patients with UTSCL treated by Posterior Extensive Circumferential Decompressive Reconstructive (PECDR) procedure. Read More

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December 2018
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Beneficial Effect of Curcumin Nanoparticles-Hydrogel on Excisional Skin Wound Healing in Type-I Diabetic Rat: Histological and Immunohistochemical Studies.

Ann Anat 2018 Dec 3. Epub 2018 Dec 3.

Department of Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt.

Management of diabetic wounds remains a major challenge in the medical field, mostly due to incompetent outcomes of treatments. Curcumin has been documented as anti-inflammatory, antioxidant, antimicrobial and antineoplastic agent in addition to wound healing activities. However, its poor aqueous solubility and impaired skin permeation handicap its topical pharmaceutical usage. Read More

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December 2018
7 Reads

Microbiota control acute arterial inflammation and neointimal hyperplasia development after arterial injury.

PLoS One 2018 6;13(12):e0208426. Epub 2018 Dec 6.

Division of Vascular Surgery, Northwestern University, Chicago, IL, United States of America.

Background: The microbiome has a functional role in a number of inflammatory processes and disease states. While neointimal hyperplasia development has been linked to inflammation, a direct role of the microbiota in neointimal hyperplasia has not yet been established. Germ-free (GF) mice are an invaluable model for studying causative links between commensal organisms and the host. Read More

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December 2018
3 Reads

LINC01118 Modulates Paclitaxel Resistance of Epithelial Ovarian Cancer by Regulating miR-134/ABCC1.

Authors:
Cong Shi Min Wang

Med Sci Monit 2018 Dec 6;24:8831-8839. Epub 2018 Dec 6.

Department of Gynecology and Obstetrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China (mainland).

BACKGROUND Epithelial ovarian cancer (EOC) has a high mortality rate and is a common malignant tumor of women, seriously impairing health. Chemoresistance is one of the major causes of poor prognosis. Therefore, analyzing the molecular mechanism of paclitaxel resistance has great significance. Read More

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December 2018
1 Read

Wound Expo 2018 highlights.

Authors:
Fatima Bibi

Br J Community Nurs 2018 Dec;23(Sup12):S26-S27

Project Manager, MA Healthcare.

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December 2018

Wound Exudate.

Authors:
Peter Bradley

Br J Community Nurs 2018 Dec;23(Sup12):S28-S32

Editor, British Journal of Healthcare Assistants.

Tina Chambers, Independent Tissue Viability Consultant. Read More

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December 2018

Pressure ulcer definitions and core curricula-how does this affect wound care and the older patient?

Br J Community Nurs 2018 Dec;23(Sup12):S6-S12

Professor and Director for the Institute of Skin Integrity and Infection prevention, Department of Nursing and Midwifery, University of Huddersfield, Queensgate, Huddersfield, West Yorkshire.

Chronic wounds are associated with a significant patient, healthcare and financial burden and can have extensive implications for healthcare. Age is a significant risk factor for developing chronic wounds, due to physical changes in skin integrity and several age-related complex comorbidities, including poor nutrition and mobility. Pressure ulcers (PU) are a common type of chronic wound that can have a substantial impact on health-related quality of life and patient outcomes. Read More

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December 2018
3 Reads

Wound care in older adults.

Authors:
Alexandra Carlin

Br J Community Nurs 2018 Dec;23(Sup12):S18-S22

Lecturer, University of Lincoln.

Wound care in older adults is complex. A logical, structured approach should be taken, using a nursing process such as assessing, planning, implementing and evaluating. This clinical focus paper outlines the nursing process to support wound care in this patient group. Read More

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December 2018

Implant of ATOMS® system for the treatment of postoperative male stress urinary incontinence: results of a single centre.

Int Braz J Urol 2018 Oct 30;44. Epub 2018 Oct 30.

Department of Neuro-Urology, CTO - Spinal Unit, Città della Salute e della Scienza di Torino, Turin, Italy.

Purpose: The aim of our study is to evaluate the efficacy and safety of ATOMS® system for the treatment of postoperative male stress urinary incontinence (SUI).

Materials And Methods: We retrospectively evaluated all patients treated at our institution for postoperative male SUI with ATOMS® implant. We excluded patients with low bladder compliance (< 20 mL / cmH2O), uncontrolled detrusor overactivity, detrusor underactivity (BCI < 100), urethral or bladder neck stricture and low cystometric capacity (< 200 mL). Read More

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October 2018

Incidence of adverse events attributable to bupivacaine liposome injectable suspension or plain bupivacaine for postoperative pain in pediatric surgical patients: a retrospective matched cohort analysis.

Paediatr Anaesth 2018 Dec 6. Epub 2018 Dec 6.

Departments of Outcomes Research, Cleveland Clinic, Cleveland, Ohio, United States.

Background: Surgical wound infiltration with local anesthetics is common as part of multimodal analgesia and enhanced recovery pathways in pediatric surgical patients. Liposomal bupivacaine can provide up to 92 hours of pain relief, and was approved by the U.S Food and Drug Administration for local infiltration in adults. Read More

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December 2018

Role of epithelial-to-mesenchymal transition in inflammatory bowel disease.

J Crohns Colitis 2018 Dec 6. Epub 2018 Dec 6.

IBD Center, Department of Gastroenterology, Humanitas Research Hospital, Rozzano, Milan, Italy.

Intestinal fibrosis is an inevitable complication in patients with inflammatory bowel disease (IBD), occurring in its two major clinical manifestations: ulcerative colitis and Crohn's disease. Fibrosis represents the final outcome of the host reaction to persistent inflammation which triggers a prolonged wound healing response resulting in the excessive deposition of extracellular matrix, eventually leading to intestinal dysfunction. The process of epithelial-to-mesenchymal transition (EMT) represents an embryonic program relaunched during wound healing, fibrosis and cancer. Read More

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December 2018
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Characterization of the Blister Fluid Proteome for Pediatric Burn Classification.

J Proteome Res 2018 Dec 6. Epub 2018 Dec 6.

Blister fluid (BF) is a novel and viable research matrix for burn injury study, which can reflect both systemic and local micro-environmental responses. The protein abundance in BF from different burn severities were initially observed using a 2D SDS-PAGE approach. Subsequently, a quantitative data independent acquisition (DIA) method - SWATHTM was employed to characterize the proteome of pediatric burn blister fluid. Read More

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December 2018
2 Reads

Irritative potency of selected wound antiseptics in the hen's egg test on chorioallantoic membrane to predict their compatibility to wounds.

Wound Repair Regen 2018 Dec 5. Epub 2018 Dec 5.

Institute of Hygiene and Environmental Medicine, University Medicine Greifswald, Greifswald, Germany.

Antiseptics are being used for prevention of infections in acute wounds and for treatment of infections in acute and chronic wounds. However, some antiseptics' high tissue toxicity might delay the healing process. The aim of this study was to investigate the tissue toxicity of preferentially used wound antiseptics and the influence of antiphlogistic additives via the hen's egg test on the chorioallantoic membrane (HET-CAM). Read More

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December 2018
2 Reads

Therapeutic strategies for skin regeneration based on biomedical substitutes.

J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.

Biosanitary Research Institute of Granada (ibs.GRANADA), University Hospitals of Granada-University of Granada, Granada, E-18071, Spain.

Regenerative medicine and tissue engineering (TE) have experienced significant advances in the development of in vitro engineered skin substitutes, either for replacement of lost tissue in skin injuries or for the generation of in vitro human skin models to research. However, currently available skin substitutes present different limitations such as expensive costs, abnormal skin microstructure and engraftment failure. Given these limitations, new technologies, based on advanced therapies and regenerative medicine, have been applied to develop skin substitutes with several pharmaceutical applications that include injectable cell suspensions, cell-spray devices, sheets or 3D-scaffolds for skin tissue regeneration and others. Read More

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December 2018
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Downregulation of long noncoding RNA SNHG1 inhibits cell proliferation, metastasis, and invasion by suppressing the Notch-1 signaling pathway in pancreatic cancer.

J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.

Department of Hepatopancreatobiliary Surgery, Central Hospital of Xuzhou, Affiliated to Dongan University, Jiangsu, China.

Background: Pancreatic cancer (PC) has become the fourth most lethal among human cancers. Long noncoding RNAs (lncRNAs) have been reported to play a role in the progression of a variety of cancers. However, the role of lncRNA SNHG1 in PC is not clear. Read More

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December 2018

Modified Hinderer's Technique for Serious Proximal Hypospadias with Ventral Curvature: Outcomes and Our Experience.

Urol J 2018 Dec 6. Epub 2018 Dec 6.

Department of Pediatric Surgery, Selcuk University Medical Faculty, Konya,Turkey.

Purpose: Hypospadias is a congenital anomaly that includes defi-cient ventral structure of the penis. Proximal hypospadias cases make up 20% of all hypospadias cases. The choice of operative technique for hypospadias repair depends on the severity, and it is influenced by the surgeon's experience and perception of where priorities should lie. Read More

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December 2018

Minimally invasive plate osteosynthesis (MIPO) in AO/OTA type B displaced clavicle fractures.

Musculoskelet Surg 2018 Dec 5. Epub 2018 Dec 5.

Department of Orthopaedics, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, 576104, India.

Introduction: Open reduction and plate fixation is known to reduce chances of malunion and symptomatic nonunion in displaced middle-third clavicle fractures. However, this treatment modality is also associated with several complications, such as hardware irritation, numbness around the surgical scar, infection, nonunion and implant failure. The minimally invasive plate osteosynthesis (MIPO) technique may reduce these complications. Read More

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December 2018

Characteristic "neck collar" injuries in Australian sea lions (Neophoca cinerea) caused by marine debris.

Forensic Sci Med Pathol 2018 Dec 5. Epub 2018 Dec 5.

Australian Marine Wildlife Research and Rescue Organization (AMWRRO), Adelaide, South Australia, 5000, Australia.

An adult male Australian sea lion (Neophoca cinerea) presented with a deep, almost circumferential, incised wound around the neck caused by a noose formed by a single strand of green nylon rope. The wound extended 4-5 cm deeply through the skin and blubber into skeletal muscle, predominantly on the dorsal surface and left side, but had not involved the airway or major vessels. The edges of the wound were sharply incised and oozing blood with a granulating infected base. Read More

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December 2018
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pH-responsive calcium alginate hydrogel laden with protamine nanoparticles and hyaluronan oligosaccharide promotes diabetic wound healing by enhancing angiogenesis and antibacterial activity.

Drug Deliv Transl Res 2018 Dec 5. Epub 2018 Dec 5.

School of Pharmacy, Jinzhou Medical University, Jinzhou, 121000, People's Republic of China.

Diabetic wounds as chronic wounds represent a severe, persistent complication of diabetes and, in the most extreme cases, can lead to amputation. Two critical and unfavorable factors affecting diabetic wound healing are sustained bacterial-induced chronic inflammation and disrupted vascularization. In this paper, we presented a novel, pH-responsive calcium alginate hydrogel laden with protamine nanoparticles and hyaluronan oligosaccharides, and explored its potential for accelerating diabetic wound healing. Read More

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December 2018
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Circ-TTC17 Promotes Proliferation and Migration of Esophageal Squamous Cell Carcinoma.

Dig Dis Sci 2018 Dec 5. Epub 2018 Dec 5.

Department of Oncology Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.

Background: Circular RNAs (circRNAs), a special class of noncoding RNAs with the characteristic of covalent closed-loop structure, have been widely found in various organisms. Growing evidence has shown that circRNAs play a crucial role in regulating biological functions of cancers. However, the specific role of circRNAs in esophageal squamous cell carcinoma (ESCC) remains largely unknown. Read More

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December 2018
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A literature review concerning contralateral approaches to paraclinoid internal carotid artery aneurysms.

Neurosurg Rev 2018 Dec 6. Epub 2018 Dec 6.

Department of Neurosurgery, Mainz University Hospital, Langenbeckstraße 1, 55131, Mainz, Germany.

Ipsilateral approaches remain the standard technique for clipping paraclinoid aneurysms. Surgeons must however be prepared to deal with bony and neural structures restricting accessibility. The application of a contralateral approach has been proposed claiming that some structures in the region can be better exposed from this side. Read More

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December 2018
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Prospective pilot study comparing deep sclerectomy outcomes with a long-term and intense corticosteroid treatment versus a standard one.

BMJ Open Ophthalmol 2018 31;3(1):e000165. Epub 2018 Oct 31.

Glaucoma and Neuro-Ophthalmology Department, FISABIO Oftalmologia, Valencia, Spain.

Objective: To compare prospectively intraocular pressure (IOP) results after deep sclerectomy (DS) using a topical short-term corticosteroid treatment (STCT, 1  month) versus a topical long-term and intense corticosteroid treatment (LTCT, 6 months) in a two2  year-follow-up.

Methods: Patients with medically uncontrolled open angle glaucoma were prospectively recruited and underwent a DS.

Results: We operated 45 eyes of 45 patients, 22 in STCT group and 23 in LTCT group. Read More

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October 2018

Prospective randomised controlled trial of Algisite™ M, Cuticerin™, and Sorbact® as donor site dressings in paediatric split-thickness skin grafts.

Burns Trauma 2018 27;6:33. Epub 2018 Nov 27.

Pegg Leditschke Children's Burns Centre, Queensland Children's Hospital, Children's Health Queensland Hospital and Health Service, South Brisbane, Queensland Australia.

Background: This is a parallel three-arm prospective randomised controlled trial (RCT) comparing Algisite™ M, Cuticerin™, and Sorbact® as donor site dressings in paediatric split-thickness skin grafts (STSG). All three were in current use within the Pegg Leditschke Children's Burn centre (PLCBC), the largest paediatric burns centre in Queensland, Australia. Our objective was to find the best performing dressing, following on from previous trials designed to rationalise dressings for the burn wound itself. Read More

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November 2018
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A methodology for detecting the wound state sensing in terms of its colonization of pathogenic bacteria.

MethodsX 2018 22;5:1521-1527. Epub 2018 Nov 22.

Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China.

A methodology for wound state sensing in terms of its colonization with pathogenic bacteria such as or has been developed. Here we report polydiacetylene (PDA) liposomes containing self-quenched carboxyfluorescein dye are only sensitive to toxins/enzymes secreted by Pathogenic bacteria but not by non-pathogenic species of (DH5α). The basis of the detection assay is that at high concentration, carboxyfluorescein is non-fluorescent. Read More

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November 2018
1 Read

Large variations in the practice patterns of surgical antiseptic preparation solutions in patients with open and closed extremity fractures: a cross-sectional survey.

Antimicrob Resist Infect Control 2018 29;7:148. Epub 2018 Nov 29.

3Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, ON Canada.

Background: Surgically-managed fractures, particularly open fractures, are associated with high rates of surgical site infections (SSIs). To reduce the risk of an SSI, orthopaedic surgeons routinely clean open fracture wounds in the emergency department (ED) and then apply a bandage to the open wound. Prior to the surgical incision, it is standard practice to prepare the fracture region with an antiseptic skin solution as an additional SSI prevention strategy. Read More

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November 2018
2 Reads

The impact of autotrophic versus heterotrophic nutritional pathways on colony health and wound recovery in corals.

Ecol Evol 2018 Nov 18;8(22):10805-10816. Epub 2018 Oct 18.

Department of Biology Boston University Boston Massachusetts.

For animals that harbor photosynthetic symbionts within their tissues, such as corals, the different relative contributions of autotrophy versus heterotrophy to organismal energetic requirements have direct impacts on fitness. This is especially true for facultatively symbiotic corals, where the balance between host-caught and symbiont-produced energy can be altered substantially to meet the variable demands of a shifting environment. In this study, we utilized a temperate coral-algal system (the northern star coral, and its photosynthetic endosymbiont, ) to explore the impacts of nutritional sourcing on the host's health and ability to regenerate experimentally excised polyps. Read More

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November 2018

Draft genomes of strains isolated from dried spices bring unique insights into the diversity of plant-associated strains.

Stand Genomic Sci 2018 29;13:35. Epub 2018 Nov 29.

1Center of Food Safety and Applied Nutrition, U. S. Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708 USA.

is a Gram-negative opportunistic pathogen that causes life- threatening infantile infections, such as meningitis, septicemia, and necrotizing enterocolitis, as well as pneumonia, septicemia, and urinary tract and wound infections in adults. Here, we report 26 draft genome sequences of , which were obtained from dried spices from the USA, the Middle East, China, and the Republic of Korea. The average genome size of the genomes was 4393 kb, with an average of 4055 protein coding genes, and an average genome G + C content of 56. Read More

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November 2018
1 Read

TFF3 Contributes to Epithelial-Mesenchymal Transition (EMT) in Papillary Thyroid Carcinoma Cells via the MAPK/ERK Signaling Pathway.

J Cancer 2018 31;9(23):4430-4439. Epub 2018 Oct 31.

Department of Histology and Embryology, Hebei North University, Zhangjiakou, 075000, China.

Trefoil factor 3 (TFF3) was found to be overexpressed in many types of tumours. Evidence has shown that TFF3 plays an important role in tumour proliferation, migration and invasion metastasis. However, the impact of TFF3 on patients' clinicopathological characteristics and underlying mechanisms remain unknown in papillary thyroid carcinoma (PTC). Read More

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October 2018
1 Read

Long Non-coding RNA LINC01234 Regulates Proliferation, Invasion and Apoptosis in Esophageal Cancer Cells.

J Cancer 2018 20;9(22):4242-4249. Epub 2018 Oct 20.

Beijing Key Laboratory of Environmental and Viral Oncology, College of Life Science and Bio-Engineering, Beijing University of Technology, Beijing, China.

Esophageal cancer is one of the leading malignancies globally and long non-coding RNAs (lncRNAs) have been proved to have an important role in different malignancies including esophageal cancer. However their role in disease progression is still not clear. The objective of the study was to investigate the expression and role of LINC01234 in progression of esophageal cancer cells. Read More

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October 2018

Emerging Roles of the Membrane Potential: Action Beyond the Action Potential.

Front Physiol 2018 21;9:1661. Epub 2018 Nov 21.

Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom.

Whilst the phenomenon of an electrical resting membrane potential (RMP) is a central tenet of biology, it is nearly always discussed as a phenomenon that facilitates the propagation of action potentials in excitable tissue, muscle, and nerve. However, as ion channel research shifts beyond these tissues, it became clear that the RMP is a feature of virtually all cells studied. The RMP is maintained by the cell's compliment of ion channels. Read More

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November 2018
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Comparative Transcriptomics of Rat and Axolotl After Spinal Cord Injury Dissects Differences and Similarities in Inflammatory and Matrix Remodeling Gene Expression Patterns.

Front Neurosci 2018 13;12:808. Epub 2018 Nov 13.

Department of Infection, Immunity & Inflammation, University of Leicester, Leicester, United Kingdom.

Following spinal cord injury in mammals, maladaptive inflammation, and matrix deposition drive tissue scarring and permanent loss of function. In contrast, axolotls regenerate their spinal cord after severe injury fully and without scarring. To explore previously unappreciated molecules and pathways that drive tissue responses after spinal cord injury, we performed a 4-way intersection of rat and axolotl transcriptomics datasets and isolated shared genes with similar or differential expression at days 1, 3, and 7 after spinal cord injury in both species. Read More

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November 2018

Carotid blowout syndrome: modern trends in management.

Cancer Manag Res 2018 13;10:5617-5628. Epub 2018 Nov 13.

International Head and Neck Scientific Group Padua, Italy.

Carotid blowout syndrome (CBS) refers to rupture of the carotid artery and is an uncommon complication of head and neck cancer that can be rapidly fatal without prompt diagnosis and intervention. CBS develops when a damaged arterial wall cannot sustain its integrity against the patient's blood pressure, mainly in patients who have undergone surgical procedures and radiotherapy due to cancer of the head and neck, or have been reirradiated for a recurrent or second primary tumor in the neck. Among patients irradiated prior to surgery, CBS is usually a result of wound breakdown, pharyngocutaneous fistula and infection. Read More

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November 2018

Efficacy of a repair cream containing Rhealba oat plantlets extract l-ALA-l-GLU dipeptide, and hyaluronic acid in wound healing following dermatological acts: a meta-analysis of >2,000 patients in eight countries corroborated by a dermatopediatric clinical case.

Clin Cosmet Investig Dermatol 2018 13;11:579-589. Epub 2018 Nov 13.

Pierre Fabre Dermo-Cosmétique, A-DERMA, Lavaur, France,

Background: The frequency of dermatological acts is increasing. These procedures often cause injuries and traumatic alterations in specific skin layers, slowing down wound healing.

Patients And Methods: An open observational study lasting 1 month was conducted on 2,363 patients who had undergone various dermatological procedures. Read More

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November 2018
2 Reads

Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis.

Cell Death Dis 2018 Dec 5;9(12):1166. Epub 2018 Dec 5.

CellCOM research Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Servizo Galego de Saúde (SERGAS), Universidade da Coruña (UDC), Xubias de Arriba, 84, 15006 A, Coruña, Spain.

Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a leading cause of disability and pain worldwide. In OA, chondrocytes in cartilage undergo phenotypic changes and senescence, restricting cartilage regeneration and favouring disease progression. Similar to other wound-healing disorders, chondrocytes from OA patients show a chronic increase in the gap junction channel protein connexin43 (Cx43), which regulates signal transduction through the exchange of elements or recruitment/release of signalling factors. Read More

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December 2018

Differential effects of type 1 diabetes mellitus and subsequent osteoblastic β-catenin activation on trabecular and cortical bone in a mouse model.

Exp Mol Med 2018 Dec 5;50(12):158. Epub 2018 Dec 5.

State Key Laboratory of Trauma, Burn and Combined Injury, Department of War Wound Rescue Skills Training, Base of Army Health Service Training, Army Medical University, 400038, ChongQing, China.

Type 1 diabetes mellitus (T1DM) is a pathological condition associated with osteopenia. WNT/β-catenin signaling is implicated in this process. Trabecular and cortical bone respond differently to WNT/β-catenin signaling in healthy mice. Read More

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December 2018
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CAP2 mutation leads to impaired actin dynamics and associates with supraventricular tachycardia and dilated cardiomyopathy.

J Med Genet 2018 Dec 5. Epub 2018 Dec 5.

The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben Gurion University, Beer Sheva, Israel.

Background: Dilated cardiomyopathy (DCM) is a primary myocardial disease leading to contractile dysfunction, progressive heart failure and excessive risk of sudden cardiac death. Around half of DCM cases are idiopathic, and genetic factors seem to play an important role.

Aim: We investigated a possible genetic cause of DCM in two consanguineous children from a Bedouin family. Read More

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December 2018

Incidence of surgical wound infection in renal surgery. The effect of antibiotic prophylaxis appropriateness. A prospective cohort study.

Actas Urol Esp 2018 Dec 7;42(10):639-644. Epub 2018 Jul 7.

Unidad de Medicina Preventiva, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, España; Centro de Salud Los Cármenes, Madrid, España; Departamento de Medicina Preventiva y Salud Pública, Universidad Rey Juan Carlos, Alcorcón, Madrid, España. Electronic address:

Objective: To assess compliance with the antibiotic prophylaxis protocol for patients who underwent renal surgery and its effect on the incidence of surgical wound infection.

Material And Methods: We performed a prospective cohort study and assessed the overall compliance and each aspect of the antibiotic prophylaxis (start, administration route, antibiotic of choice, duration and dosage) and reported the compliance rates. The qualitative variables were compared with the chi-squared test, and the quantitative variables were compared with Student's t-test. Read More

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December 2018

Anti-metastatic and anti-proliferative activity of eugenol against triple negative and HER2 positive breast cancer cells.

BMC Complement Altern Med 2018 Dec 5;18(1):321. Epub 2018 Dec 5.

Pharmacology and toxicology department, King Saud University, Riyadh, Saudi Arabia.

Background: Eugenol is a natural phenolic compound and possesses anticancer and antibacterial activities. Breast cancer is a major global health problem, and most of the chemotherapeutic agents are highly toxic with long-term side effects. Therefore, this study aimed to explore the possibility of using eugenol as an anti-metastatic and anti-proliferative agent against MDA-MB-231 and SK-BR-3 breast cancer cells. Read More

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December 2018

Algal Oxylipins Mediate the Resistance of Diatoms against Algicidal Bacteria.

Mar Drugs 2018 Dec 4;16(12). Epub 2018 Dec 4.

Institute for Inorganic and Analytical Chemistry, Bioorganic Analytics, Friedrich Schiller University Jena, Lessingstr. 8, D-07743 Jena, Germany.

Algicidal bacteria can lyse microalgal blooms and trigger shifts within plankton communities. Resistant algal species can escape lysis, and have the opportunity to dominate the phytoplankton after a bacterial infection. Despite their important function in ecosystem regulation, little is known about mechanisms of resistance. Read More

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December 2018

Annexin A1 May Induce Pancreatic Cancer Progression as a Key Player of Extracellular Vesicles Effects as Evidenced in the In Vitro MIA PaCa-2 Model System.

Int J Mol Sci 2018 Dec 4;19(12). Epub 2018 Dec 4.

Department of Pharmacy, University of Salerno, via Giovanni Paolo II 132, 84084 Fisciano, Italy.

Pancreatic Cancer (PC) is one of the most aggressive malignancies worldwide. As annexin A1 (ANXA1) is implicated in the establishment of tumour metastasis, the role of the protein in PC progression as a component of extracellular vesicles (EVs) has been investigated. EVs were isolated from wild type (WT) and ANXA1 knock-out (KO) PC cells and then characterised by multiple approaches including Western blotting, Field Emission-Scanning Electron Microscopy, and Dynamic Light Scattering. Read More

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December 2018
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Bicellular Tight Junctions and Wound Healing.

Int J Mol Sci 2018 Dec 4;19(12). Epub 2018 Dec 4.

Center for Wound Healing and Tissue Regeneration, College of Dentistry, University of Illinois at Chicago, 801 S. Paulina Street, Chicago, IL 60612, USA.

Bicellular tight junctions (TJs) are intercellular junctions comprised of a variety of transmembrane proteins including occludin, claudins, and junctional adhesion molecules (JAMs) as well as intracellular scaffold proteins such as zonula occludens (ZOs). TJs are functional, intercellular structures that form a barrier between adjacent cells, which constantly seals and unseals to control the paracellular passage of molecules. They are primarily present in the epithelial and endothelial cells of all tissues and organs. Read More

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December 2018

Stress-Triggered Long-Distance Communication Leads to Phenotypic Plasticity: The Case of the Early Root Protoxylem Maturation Induced by Leaf Wounding in Arabidopsis.

Plants (Basel) 2018 Dec 4;7(4). Epub 2018 Dec 4.

Department of Science, University "Roma Tre", 00146 Rome, Italy.

Root architecture and xylem phenotypic plasticity influence crop productivity by affecting water and nutrient uptake, especially under those environmental stress, which limit water supply or imply excessive water losses. Xylem maturation depends on coordinated events of cell wall lignification and developmental programmed cell death (PCD), which could both be triggered by developmental- and/or stress-driven hydrogen peroxide (H₂O₂) production. Here, the effect of wounding of the cotyledonary leaf on root protoxylem maturation was explored in by analysis under Laser Scanning Confocal Microscope (LSCM). Read More

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December 2018

Using the Probability of Cesarean from a Validated Cesarean Prediction Calculator to Predict Labor Length and Morbidity.

Am J Perinatol 2018 Dec 3. Epub 2018 Dec 3.

Maternal and Child Health Research Center, Department of Obstetrics & Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

Objective:  To determine if increasing predicted risk of cesarean was associated with longer labor length and increased morbidity among women undergoing induction with an unfavorable cervix.

Study Design:  Using a publically available database, we evaluated whether a previously validated prediction model for cesarean delivery after induction was associated with labor length, maternal morbidity (third-/fourth-degree lacerations, endometritis, blood transfusion, wound infection, venous thromboembolism, hysterectomy, intensive care unit admission, and death), and neonatal morbidity (blood transfusion, encephalopathy, intraventricular hemorrhage, severe respiratory distress syndrome, necrotizing enterocolitis, and sepsis). Full-term (≥37 weeks) singleton gestations with intact membranes and an unfavorable cervix (Bishop score ≤6 and dilation ≤2 cm) undergoing induction of labor were included. Read More

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December 2018

Biodegradable amino acid-based poly(ester amine) with tunable immunomodulating properties and their in vitro and in vivo wound healing studies in diabetic rats' wounds.

Acta Biomater 2018 Nov 30. Epub 2018 Nov 30.

Department of Fiber Science and Apparel Design, Cornell University, Ithaca, NY, 14853-4401, USA. Electronic address:

The objective of this study is to design a new family of biodegradable synthetic polymeric biomaterials for providing a tunable inhibition of macrophage's nitric oxide synthase (NOS) pathway. L-Arginine (Arg) is the common substrate for NOS and arginase. Both two metabolic pathways participate in the wound healing process. Read More

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November 2018
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Steered migration and changed morphology of human astrocytes by an applied electric field.

Exp Cell Res 2018 Nov 30. Epub 2018 Nov 30.

Department of Neurosurgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, People's Republic of China; Shanghai Institute of Head Trauma, Shanghai 200127, People's Republic of China. Electronic address:

Direct current electric field (DC EF) plays a role in influencing the biological behaviors and functions of cells. We hypothesize that human astrocytes (HAs) could also be influenced in EF. Astrocytes, an important type of nerve cells with a high proportion quantitatively, are generally activated and largely decide the brain repair results after brain injury. Read More

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November 2018

Intravenous Lidocaine Administered as Twice Daily Bolus and Continuous Infusion for Intractable Cancer Pain and Wound Care Pain.

J Palliat Med 2018 Dec 1. Epub 2018 Dec 1.

3 Spectrum Health Medical Group , Palliative Care Medicine, Grand Rapids, Michigan.

Introduction: Intravenous lidocaine is an option for intractable pain caused by advancing cancer and wound care. We report a case of intractable cancer pain and wound care pain managed with concurrent use of lidocaine administered as a twice daily intravenous bolus in addition to continuous intravenous infusion.

Case Description: A 31-year-old male with rapidly progressing locally advanced squamous cell cancer affecting the gluteal area developed extensive painful and purulent ulcerating wounds affecting the coccyx, superior gluteal cleft, and buttocks. Read More

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December 2018
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A new propeller trapezius muscle flap for reconstruction of posterior trunk defects: An anatomic study and report of three cases.

Microsurgery 2018 Dec 3. Epub 2018 Dec 3.

Department of Plastic and Reconstructive Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio.

Background: Reconstruction of complex back defects, especially after corrective spine surgery, is a challenging problem. In these patients hardware issues predominate and flap failure has serious consequences. Certain subunits of the back pose even greater problems, specifically the central region between T9 and T12. Read More

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December 2018
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