Search Our Scientific Publications & Authors

Anticancer Drugs 2019 Mar 20. Epub 2019 Mar 20.

Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China.

To investigate the role of long noncoding RNA taurine-upregulated gene 1 (TUG1) on ovarian cancer-induced angiogenesis and to explore possible signaling pathways. Ovarian cancer cell line SKOV3 or CAOV3 was transfected with short hairpin-TUG1 to suppress TUG1 expression. Supernatant from cultured cancer cells was used as a condition medium to incubate endothelial cell line human umbilical vein endothelial cells, whose proliferation rate was quantified by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Read More

J Dent Sci 2018 Jun 6;13(2):103-108. Epub 2017 Dec 6.

Department of Pathology, Faculty of Medicine, University of Niš, Zorana Đinđića 81, 18000 Niš, Serbia.

Background/purpose: Tooth extraction is often followed by a number of different complications that demand additional treatment. In order to accelerate healing processes and decrease the complication occurrence various agents, growth factors, natural and synthetic antioxidants (e.g coenzyme Q-CoQ), are applied. Read More

Curr Drug Deliv 2019 Mar 20. Epub 2019 Mar 20.

Department of Drug Sciences, University of Pavia, 27100 Pavia. Italy.

Chronic wounds are the result of alterations in the complex series of events of physiological wound healing. In particular, the prolonged inflammation results in increased protease activity, in the degradation of extracellular matrix (ECM) and of growth factors (GFs). The relevance of platelet GFs in maintaining and restoring the complex equilibrium of different moments in wound healing is well recognized. Read More

Cytokine Growth Factor Rev 2019 Mar 12. Epub 2019 Mar 12.

Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, 2028, South Africa. Electronic address:

Activated phosphatidylinositol 3 kinase/Protein kinase B (PI3K/AKT) signalling with increased or reduced mTOR and GSK3β activity influences the wound repair process. Diabetic wounds, usually ulcerated, are characterised by reduced growth factors and cellular performance. The occurrence of diabetic ulcers is linked to peripheral arterial disease, neuropathy, and wound contamination. Read More

Plast Reconstr Surg Glob Open 2018 Nov 21;6(11):e2010. Epub 2018 Nov 21.

Center for Stem Cell Research & Regenerative Medicine, Tulane University School of Medicine, New Orleans, La.

Background: Processed microvascular tissue (PMVT), a human structural allograft, is derived from lyophilized human tissue containing microcirculatory cellular components. Since PMVT serves as a source of extracellular matrix (ECM), growth factors, cytokines, and chemokines modulating angiogenesis, inflammation, apoptosis, and endogenous cell recruitment, we hypothesized its application would accelerate wound regeneration in a validated pressure ulcer (PU) model developed in C57BL/6 mice using two 24-hour cycles of skin ischemia/reperfusion created by placement and removal of external magnets.

Methods: Two identical PU injuries (n = 50 female mice) were treated with (a) topical particulate PMVT, (b) injected rehydrated PMVT, or (c) saline control injection, and assessed daily for closure rates, scab formation/removal, and temperature. Read More

Stem Cell Res Ther 2019 Mar 15;10(1):94. Epub 2019 Mar 15.

Institute for Regenerative Medicine, Sechenov University, Moscow, Russia.

The skin is the largest organ of the body, which meets the environment most directly. Thus, the skin is vulnerable to various damages, particularly burn injury. Skin wound healing is a serious interaction between cell types, cytokines, mediators, the neurovascular system, and matrix remodeling. Read More

Expert Opin Drug Discov 2019 Mar 14:1-13. Epub 2019 Mar 14.

a Department of Medical Cell Biology , Uppsala University , Uppsala , Sweden.

Introduction: Chronic, nonhealing skin wounds claim >3% of the health-care budget in industrialized countries, and the incidence is rising. Currently, two parallel trends influence innovations within the field of wound healing: the need to reduce spread of antibiotic resistance and the emerging use of health economy and value-based models. Areas covered: This review focuses on the discovery of drug candidates and development of treatments aiming to enhance wound healing in the heterogeneous group of patients with nonhealing wounds. Read More

Oncol Rep 2019 Mar 7. Epub 2019 Mar 7.

Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, Julius Maximilian University of Wuerzburg, 97080 Würzburg, Germany.

Wound healing begins immediately after surgery with a modification of the microenvironment via a well‑orchestrated interaction between cells, cytokines and growth factors. Some of these growth factors and cytokines have mitogenic effects on cancer cells, which may lead to enhanced cancer cell proliferation and early metastatic events. The present study aimed to investigate the effects of wound fluid (WF) on the head and neck squamous carcinoma cell lines FaDu and HLaC78 in vitro. Read More

Chin Med J (Engl) 2019 Mar;132(6):680-689

Center of Otolaryngology Head and Neck Surgery, Chinese PLA Navy General Hospital, Beijing 100048, China.

Background: Several patients experience persistent otorrhea after a flawless surgical procedure because of insufficient epithelial healing. Several efforts, such as autologous tissue allograft and xenograft, have been made to halt otorrhea. However, a stable technology to induce temporal epithelial repair is yet to be established. Read More

Int Wound J 2019 Mar 10. Epub 2019 Mar 10.

Research and Development, Organogenesis Inc., Birmingham, Alabama.

The purpose of this study is to characterise the composition of a dehydrated amnion and chorion graft and investigate how factors released from this graft interact with cells important to the wound microenvironment using in vitro models. Characterisation was completed by proteomic analysis of growth factors and cytokines, evaluation of matrix components and protease inhibition, immunohistochemistry, and in vitro release of key growth factors and cytokines. To evaluate the effect of released factors on cells found within the microenvironment, in vitro assays including: cell proliferation, migration, gene expression, protein production, and intracellular pathway activation were used; additionally, responses of fibroblasts in the context of inflammation were measured. Read More

Eur J Pharm Biopharm 2019 Mar 7. Epub 2019 Mar 7.

CICS-UBI - Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, Portugal; CIEPQPF - Departamento de Engenharia Química, Universidade de Coimbra, Rua Silvio Lima, 3030-790 Coimbra, Portugal. Electronic address:

Nowadays, despite the intensive research performed in the area of skin tissue engineering, the treatment of skin lesions remains a big challenge for healthcare professionals. In fact, none of the wound dressings currently used in the clinic is capable of re-establishing all the native features of skin. An ideal wound dressing must confer protection to the wound from external microorganisms, chemical, and physical aggressions, as well as promote the healing process by stimulating the cell adhesion, differentiation, and proliferation. Read More

Curr Mol Pharmacol 2019 Mar 6. Epub 2019 Mar 6.

Jiangsu key laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009. China.

Background: Aggressive behavior of tumor metastasis comes from certain mutations, changes in cellular metabolic and signaling pathways that are majorly altered by tumor microenvironment (TME), its other components and growth factors like transforming growth factor-β1 (TGF-β1) which is chiefly known for its epithelial to mesenchymal transformation (EMT). EMT is a critical step of metastasis cascade in actual human lung cancer scenario.

Objective: Our present study is focused to unveil the in-vivo metastatic behavior of TGF-β1 treated lung cancer cells that undergone EMT. Read More

Adv Healthc Mater 2019 Mar 5:e1900104. Epub 2019 Mar 5.

Department of Chemical and Biomolecular Engineering and Institute for NanoBioTechnology, The Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD, 21218, USA.

Wound healing is a multifaceted biological process involving the replacement of damaged tissues and cellular structures, restoring the skin barrier's function, and maintaining internal homeostasis. Over the past two decades, numerous approaches are undertaken to improve the quality and healing rate of complex acute and chronic wounds, including synthetic and natural polymeric scaffolds, skin grafts, and supramolecular hydrogels. In this context, this review assesses the advantages and drawbacks of various types of supramolecular hydrogels including both polymeric and peptide-based hydrogels for wound healing applications. Read More

Korean J Physiol Pharmacol 2019 Mar 15;23(2):151-159. Epub 2019 Feb 15.

Department of Physiology, Chung-Ang University College of Medicine, Seoul 06974, Korea.

Pruritus (itching) is classically defined as an unpleasant cutaneous sensation that leads to scratching behavior. Although the scientific criteria of classification for pruritic diseases are not clear, it can be divided as acute or chronic by duration of symptoms. In this study, we investigated whether skin injury caused by chemical (contact hypersensitivity, CHS) or physical (skin-scratching stimulation, SSS) stimuli causes initial pruritus and analyzed gene expression profiles systemically to determine how changes in skin gene expression in the affected area are related to itching. Read More

Neurochem Int 2019 May 25;125:144-150. Epub 2019 Feb 25.

Department of Plastic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

Skin wound healing is a complex and dynamic biological process that involves many different cell types, the extracellular matrix, and mediators, such as neuropeptides, growth factors, and cytokines. Similar to diseases of the central nervous system, neurovascular interactions have been shown to play a pivotal role in skin wound healing, for example, as seen in the delayed healing of denervated skin. In aspects involving neurovascular interactions, while angiogenesis is considered important, physiological and pathological roles of these interactions in skin wound healing remain unclear. Read More

Int J Mol Med 2019 Feb 27. Epub 2019 Feb 27.

Department of Otolaryngology, The Second Hospital, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China.

Hepatocyte growth factor (HGF) and keratinocyte growth factor (KGF), two paracrine growth factors, modulate corneal epithelial cell metabolism, apoptosis and survival. Vascular endothelial growth factor (VEGF) serves as a proangiogenic factor in corneal neovascularization (CNV), which is a major cause of vision impairment and corneal blindness. The aim of the present study was to evaluate the ability of HGF and KGF to influence VEGF and its receptor, kinase insert domain receptor (Flk‑1) in corneal injury and CNV in rats induced by ultraviolet radiation (UVR). Read More

Mater Sci Eng C Mater Biol Appl 2019 May 3;98:347-357. Epub 2019 Jan 3.

Department of Stem Cells and Regenerative Medicine, Institute for Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran.

Wound healing is a tissue regeneration process which is regulated by a complex interaction of multiple growth factors, primarily transforming growth factor-β1 (TGF-β1). The natural antagonist of transforming growth factor-β (TGF-β) signaling is Smad7. It has been shown that curcumin (an antioxidant) and some biocompatible polymers like collagen and chitosan enhance cutaneous wound healing. Read More

AORN J 2019 Mar;109(3):298-317

Chronic nonhealing wounds cause significant morbidity and mortality and remain a challenging condition to treat. Regenerative wound surgery involves operative debridement of wounds to remove dead and healing-impaired tissue and bacterial contamination and, subsequently, the application of regenerative medicine treatments to accelerate healing. Regenerative treatments aim to restore native tissue structure and function by targeting biological mechanisms underlying impaired healing. Read More

Thorac Cancer 2019 Feb 27. Epub 2019 Feb 27.

Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.

Background: ING5 is the last member of the Inhibitor of Growth (ING) candidate tumor suppressor family that has been implicated in multiple cellular functions, including cell cycle regulation, apoptosis, and chromatin remodeling. Our previous study showed that ING5 overexpression inhibits lung cancer aggressiveness and epithelial-mesenchymal transition (EMT), with unknown mechanisms.

Methods: Western blotting was used to detect total and phosphorylated levels of β-catenin and EMT-related proteins. Read More

J Tissue Eng Regen Med 2019 Feb 26. Epub 2019 Feb 26.

University Medical Center Groningen, Department of Pathology & Medical Biology, University of Groningen, Groningen, the Netherlands.

Introduction: Fat grafting is an established clinical intervention to promote tissue repair. The role of the fat's extracellular matrix (ECM) in regeneration is largely neglected. We investigated in vitro the use of human adipose tissue-derived ECM hydrogels as release platform for factors secreted by adipose derived stromal cells (ASC) MATERIAL & METHODS: Lipoaspirates from non-diabetic and diabetic donors were decellularized. Read More

Zhonghua Shao Shang Za Zhi 2019 Feb;35(2):95-103

Department of Burns and Plastic Surgery, Xiang'an Hospital of Xiamen University, Xiamen 361102, China.

To investigate the effects of basic fibroblast growth factor (bFGF) on healing of infective wound in New Zealand rabbit after debridement. Thirty-two New Zealand rabbits (3 to 4 months old, no matter male or female) were intradermally injected with 0.1 mL of complete Freund's adjuvant on the buttocks. Read More

Cells 2019 Feb 19;8(2). Epub 2019 Feb 19.

Molecular Targeting Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, 20133 Milan, Italy.

Wound healing fluid that originates from breast surgery increases the aggressiveness of cancer cells that remain after the surgery. We determined the effects of the extent of surgery and tumor-driven remodeling of the surrounding microenvironment on the ability of wound-healing to promote breast cancer progression. In our analysis of a panel of 34 cytokines, chemokines, and growth factors in wound healing fluid, obtained from 27 breast carcinoma patients after surgery, the levels of several small molecules were associated with the extent of cellular damage that was induced by surgery. Read More

Biomed Pharmacother 2019 Feb 19;112:108615. Epub 2019 Feb 19.

University Institute of Pharmacy, Pt. Ravishankar Shukla University, 492010, Raipur, C.G., India. Electronic address:

Wound management in diabetic patient is of an extreme clinical and social concern. The delayed and impaired healing makes it more critical for research focus. The research on impaired healing process is proceeding hastily evident by new therapeutic approaches other than conventional such as single growth factor, dual growth factor, skin substitutes, cytokine stimulators, cytokine inhibitors, matrix metalloproteinase inhibitors, gene and stem cell therapy, extracellular matrix and angiogenesis stimulators. Read More

Cytokine 2019 Feb 15;117:15-22. Epub 2019 Feb 15.

Department of Biochemistry and Molecular Medicine, Université de Montréal, C.P. 6128, Succ. Centre-Ville, Montréal, Québec H3C 3J7, Canada; CRCHUM, 900 Saint-Denis - Room R10.432, Montréal, QC H2X 0A9, Canada. Electronic address:

The senescence-associated secretory phenotype (SASP) defines the ability of senescent cells to express and secrete a variety of extracellular modulators that includes cytokines, chemokines, proteases, growth factors and bioactive lipids. The role of the SASP depends on the context. The SASP reinforces the senescent cell cycle arrest, stimulates the immune-mediated clearance of potentially tumorigenic cells, limits fibrosis and promotes wound healing and tissue regeneration. Read More

Infect Drug Resist 2019 29;12:297-309. Epub 2019 Jan 29.

Department of Endocrinology, Southwest Hospital, Army Medical University, Chongqing, People's Republic of China,

Aim: This study was designed to examine the potential mechanism underlying these roles of platelet-rich plasma in treating diabetic foot ulcers (DFUs).

Methods: and HaCaT were co-cultured under high glucose conditions to serve as an in vitro model for infected cells in DFUs. Platelet-rich gel (PRG) or extract liquid of platelet-rich gel (EPG) were used to interfere with the model to observe the growth of HaCaT cells and , and the effect of miR-21 changes in HaCaT cells on PDCD4, NF-κB activity and related inflammatory factors. Read More

Cell Biochem Funct 2019 Mar 18;37(2):113-124. Epub 2019 Feb 18.

Department of Ophthalmology and Visual Science, Hiroshima University, Hiroshima, Japan.

Scar formation is the most common cause for failure of glaucoma filtration surgery because of increased fibroblast proliferation and activation. We have now examined the effect of Y-27632, a Rho-associated protein kinase (ROCK) inhibitor, on postsurgical scarring formation in human Tenon fibroblasts (HTFs). Collagen gel contraction assay was used to compare contractility activity of Y-27632 with several antiglaucoma drugs. Read More

Cell Metab 2019 Mar 14;29(3):576-591. Epub 2019 Feb 14.

Memorial Sloan Kettering Cancer Center, Cancer Biology and Genetics Program, New York, NY 10065, USA. Electronic address:

The metabolic reprogramming associated with malignant transformation has led to a growing appreciation of the nutrients required to support anabolic cell growth. Less well studied is how cancer cells satisfy those demands in vivo, where they are dispersed within a complex microenvironment. Tumor-associated stromal components can support tumor growth by providing nutrients that supplement those provided by the local vasculature. Read More

Front Vet Sci 2019 30;6. Epub 2019 Jan 30.

Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.

A complex feedback of growth factors, secreted by a variety of cell types, is responsible for the mediation of skin healing. Despite the recent advances in wound healing management, this fails up to 50% and skin wounds can still be considered one of the main causes of morbidity, both in human and veterinary medicine. Regenerative medicine, involving mesenchymal stromal cells (MSCs), is nowadays a promising solution for skin wound healing. Read More

AAPS PharmSciTech 2019 Feb 12;20(3):110. Epub 2019 Feb 12.

Biological Materials Laboratory, CSIR - Central Leather Research Institute, Chennai, 600020, India.

Angiogenesis is a vital component of the orchestrated wound healing cascade and tissue regeneration process, which has a therapeutic prominence in treatment of ischemic vascular diseases and certain cardiac conditions. Based on its eminence, several strategies using growth factors have been studied to initiate angiogenesis. However, growth factors are expensive and have short half-life. Read More

BMC Cancer 2019 Feb 11;19(1):138. Epub 2019 Feb 11.

Departments of Microbiology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong.

Background: Human papillomavirus (HPV) is an etiological agent of cervical cancer. Yet co-factors are believed to be involved in HPV-mediated carcinogenesis. Polycyclic aromatic hydrocarbons (PAHs) are considered as one of these co-factors. Read More

Tissue Cell 2019 Feb 17;56:98-106. Epub 2019 Jan 17.

Department of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University, İstanbul, Turkey. Electronic address:

Cell migration is one of the major cellular processes in development, tissue regeneration, wound healing, cancer and immune function. Underlying molecular mechanism behind the fibroblast cell migration and matrix interactions generates the basis of tissue homeostasis. The role of Apelin receptor (Aplnr) signaling in gastrulation movements has emerged in recent years but how Aplnr regulates cell movement remains unclear. Read More

Int Wound J 2019 Feb 7. Epub 2019 Feb 7.

Department of Plastic Surgery, Korea University College of Medicine, Seoul, Korea.

Numerous studies have demonstrated the various medicinal properties of Panax ginseng, including angiogenic, immuno-stimulating, antimicrobial, and anti-inflammatory activities, which can be helpful in chronic wound healing. However, a direct role for P. ginseng in chronic wound healing has not been demonstrated. Read More

Oxid Med Cell Longev 2019 13;2019:7017363. Epub 2019 Jan 13.

Leibniz-Institute for Plasma Science and Technology e. V., Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany.

Small reactive oxygen and nitrogen species (ROS/RNS) driven signaling plays a significant role in wound healing processes by controlling cell functionality and wound phase transitions. The application of cold atmospheric pressure plasma (CAP), a partially ionized gas expelling a variety of ROS and RNS, was shown to be effective in chronic wound management and contrastingly also in malignant diseases. The underlying molecular mechanisms are not well understood but redox signaling events are involved. Read More

Haematologica 2019 Feb 7. Epub 2019 Feb 7.

University of Birmingham

Platelets promote wound healing by forming a vascular plug and by secreting growth factors and cytokines. Glycoprotein (GP)VI and C-type lectin-like receptor (CLEC)-2 signal through a (hem)-immunoreceptor tyrosine-based activation motif, which induce platelet activation. GPVI and CLEC-2 support vascular integrity during inflammation in the skin through regulation of leukocyte migration and function, and by sealing sites of vascular damage. Read More

Invest Ophthalmol Vis Sci 2019 Feb;60(2):605-614

Institute for Science and Technology in Medicine, School of Medicine, Keele University, Stoke-on-Trent, United Kingdom.

Purpose: Surgical techniques such as trabeculectomy aim to treat glaucoma by making an incision into the scleral tissue, to create an alternative drainage pathway for aqueous to flow into the sub-Tenon's/subconjunctival space. However, tissue fibrosis and wound healing occurring after the procedures can reduce the success rate. This study aims to investigate the synergistic effects of aqueous humor in combination with shear stress on the fibrosis response occurring in Tenon's capsule and conjunctival tissue (TCCT) after glaucoma surgery. Read More

Int J Mol Sci 2019 Feb 2;20(3). Epub 2019 Feb 2.

Department of Biocosmetics, Sungkyunkwan University, Suwon 16419, Korea.

Loliolide is a monoterpenoid hydroxylactone present in freshwater algae that has anti-inflammatory and antiaging activity; however, its effects on ultraviolet-damaged skin have yet to be elucidated. This study investigated the antiapoptosis and wound-healing effects of loliolide using HaCaT cells (a human keratinocyte cell line). Loliolide inhibited the expression of reactive oxygen species (ROS) induced by ultraviolet radiation as well as wrinkle formation-related matrix metalloproteinase genes and increased the expression of the damage repair-related gene SIRT1. Read More

Tissue Eng Part B Rev 2019 Feb 2. Epub 2019 Feb 2.

University of Nebraska Medical Center, 12284, Mary & Dick Holland Regenerative Medicine Program, Omaha, Nebraska, United States.

The management and treatment of tissue infection, especially chronic infection, represents a significant challenge. Application of autologous platelet rich plasma (PRP) has emerged as a promising adjunct therapy for facilitating the healing of surgical wounds and tissue injuries. PRP is extracted from whole blood using a sequential centrifugation technique and when activated, can release a vast array of antimicrobial proteins, cytokines, and growth factors. Read More

Anticancer Res 2019 Feb;39(2):577-584

Department of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

Background/aim: Glioblastoma (GBM) is one of the most lethal solid cancers due to its highly invasive nature. The malignant potential of GBM cells might be partially regulated by surrounding normal cells, such as oligodendrocytes or fibroblasts. The aim of this study was to examine the interaction between stromal cells and GBM cells. Read More

Stem Cell Res Ther 2019 Jan 31;10(1):47. Epub 2019 Jan 31.

Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan, 430022, China.

Background: Human adipose stem cells (ASCs) have emerged as a promising treatment paradigm for skin wounds. Recent works demonstrate that the therapeutic effect of stem cells is partially mediated by extracellular vesicles, which comprise exosomes and microvesicles. In this study, we investigate the regenerative effects of isolated microvesicles from ASCs and evaluate the mechanisms how ASC microvesicles promote wound healing. Read More

Burns Trauma 2019 25;7. Epub 2019 Jan 25.

3Graduate School of Biomedical Engineering, University of New South Wales, Sydney, NSW 2052 Australia.

There is a vast number of treatments on the market for the management of wounds and burns, representing a multi-billion dollar industry worldwide. These include conventional wound dressings, dressings that incorporate growth factors to stimulate and facilitate the wound healing process, and skin substitutes that incorporate patient-derived cells. This article will review the more established, and the recent advances in the use of biomaterials for wound healing therapies, and their future direction. Read More

Sci Transl Med 2019 Jan;11(477)

Translational Tissue Engineering Center, Baltimore, MD 21231, USA.

Biomaterials in regenerative medicine are designed to mimic and modulate tissue environments to promote repair. Biologic scaffolds (derived from decellularized tissue extracellular matrix) promote a wound-healing (proregenerative) immune phenotype and are used clinically to treat tissue loss, including in the context of tumor resection. It is unknown whether a biomaterial microenvironment that encourages tissue formation may also promote tumor development. Read More

Ther Umsch 2019 Jan;75(5):287-294

1 Klinik für Gastroenterologie und Hepatologie, UniversitätsSpital Zurich.

Perianal fistulas in CED: from mouse model to clinic Abstract. Fistulas are one of the most severe complications in Crohn's disease patients (CD). More than one third of Crohn's disease patients will suffer from mainly perianal fistulas during the course of their disease. Read More

J Thromb Haemost 2019 Jan 30. Epub 2019 Jan 30.

Department of Pathology, Duke University Medical Center, Durham, NC, USA.

Essentials Many mediators increase tissue factor (TF) expression in a wide variety of cell types. The only known example of TF downregulation is by pericytes during wound healing angiogenesis. Downregulation of TF mRNA and protein in cultured pericytes is Protein Kinase C (PKC) dependent. Read More

Stem Cells Int 2018 30;2018:4789568. Epub 2018 Dec 30.

Burn Institute, Hangang Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Republic of Korea.

Fibroblasts synthesize and secrete dermal collagen, matrix proteins, growth factors, and cytokines. These characteristics of fibroblasts provide a potential way for fibroblast therapy to treat skin ulcers more effectively than conventional therapies such as cytokine therapy and negative pressure wound therapy. However, the obstacle to the commercialization of fibroblast therapy is the limited supply of cells with consistent quality. Read More

Biomed Mater 2019 Mar 7;14(3):035003. Epub 2019 Mar 7.

Novel Drug Delivery Systems Research Center, Department of Pharmaceutics, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.

In recent years, applications of biopolymers such as hyaluronic acid (HA) for wound dressing have attracted more attention. However, the poor mechanical properties of HA-based wound dressings limit their clinical applications. Incorporation of reinforcing agents such as nanocrystalline cellulose (CNC) in HA-based wound dressings can improve their mechanical properties. Read More

Exp Ther Med 2019 Feb 6;17(2):982-989. Epub 2018 Dec 6.

Faculty of Dental Medicine, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.

Wound healing process comprises a complex network of cells and molecules that are regulated in order to pursue tissue regeneration. Our study focused on the capacity of alveolar blood clots (ABCs), platelet-rich fibrin (PRF) and plasma rich in growth factors (PRGF) to induce fibroblasts proliferation and migration as a measure of alveolar regeneration. Using cellular impedance with xCELLigence technology we quantified the proliferation and the migration capacity of L929 fibroblast standard cell line in the presence of 4 different ABCs and 3 different PRFs harvested from healthy individuals during standard tooth extraction. Read More

Mater Sci Eng C Mater Biol Appl 2019 Apr 3;97:994-1008. Epub 2019 Jan 3.

Department of Biomedical Sciences, College of Health Sciences, Qatar University, Doha 2713, Qatar.

Intentional and regulated induction of blood vessels formation which is generally referred to as therapeutic angiogenesis has a lot of potential in the management of various kinds of ischemic complications as well as in wound healing, bone regeneration and tissue engineering. Conventionally, therapeutic angiogenesis relies on the controlled application of growth factors that helps to initiate the formation of blood vessels in the target tissues and bioengineered constructs. The emergence of nanotechnology in medicine, particularly its application in molecular medicine has the potential for a tremendous progress in the therapeutic angiogenesis interventions. Read More

J Transl Med 2019 Jan 21;17(1):36. Epub 2019 Jan 21.

Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, 127 Chanle West Road, Xi'an, 710032, Shaanxi Province, China.

Background: Tissue expansion is a procedure that promotes skin regeneration by mechanical stretch. During the stress and relaxation cycle, the skin undergoes a repeated microtrauma which triggers an immune response leading to the recruitment of macrophages to repair the damaged tissue. Macrophages have been found to be necessary for tissue repair and wound healing, but their effects on skin regeneration during mechanical stretch remain unclear. Read More

Eur J Med Chem 2019 Mar 9;165:107-114. Epub 2019 Jan 9.

Sorbonne Université, CNRS, IPCM, UMR 8232, 4 place Jussieu, 75005 Paris, France; Institute for Interdisciplinary Research, Jianghan University, Wuhan Economic and Technological Development Zone, Wuhan 430056, China. Electronic address:

Ganglioside GM3, belonging to glycosphingolipid family, has been known as tumor-associated carbohydrate antigen on several types of tumor. Many studies have revealed that GM3 plays a role in cell proliferation, adhesion and differentiation, which is crucial in the process of cancer development. In the present study, we firstly synthesized novel mannose-containing GM3 analogues by enzymatic hydrolysis and chemical procedures. Read More

Acta Biomater 2019 Mar 18;87:76-87. Epub 2019 Jan 18.

U.S. Army Institute of Surgical Research, Combat Trauma and Burn Injury Research, JBSA Fort Sam Houston, TX, USA. Electronic address:

Despite great advances in skin wound care utilizing grafting techniques, the resulting severe scarring, deformity and ineffective vascularization remains a challenge. Alternatively, tissue engineering of new skin using patient-derived stem cells and scaffolding materials promises to greatly increase the functional and aesthetic outcome of skin wound healing. This work focused on the optimization of a polyethylene glycol modified (PEGylated) platelet-rich plasma (PRP) hydrogel for the protracted release of cytokines, growth factors, and signaling molecules and also the delivery of a provisional physical framework for stem cell angiogenesis. Read More