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Arq Bras Oftalmol 2019 Jan-Feb;82(1):78-84

Centro Avançado de Superfície Ocular, Departamento de Oftalmologia e Ciências Visuais, Universidade Federal de São Paulo, São Paulo, SP, Brasil.

The transparency and maintenance of corneal epithelial integrity are essential for its optical properties and, to preserve these characteristics, the epithelium undergoes continuous renewal. This renewal depends on the control of cell proliferation and differentiation mediated by mitogenic factors responsible for increasing mitoses and stimulating cellular migration. Cell-cell communication plays a pivotal role in epithelial healing process, and several cytokines and growth factors are involved in this process. Read More

J Tissue Eng Regen Med 2019 Jan 15. Epub 2019 Jan 15.

Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia.

Recent studies suggest that the main driving force behind the therapeutic activity observed in mesenchymal stem cells (MSCs) are the paracrine factors secreted by these cells. These biomolecules also trigger anti-apoptotic events to prevent further degeneration of the diseased organ through paracrine signalling mechanisms. In comparison to the normal physiological conditions, an increased paracrine gradient is observed within the peripheral system of diseased organs which enhances the migration of tissue specific MSCs towards the site of infection or injury to promote healing. Read More

Int J Mol Sci 2019 Jan 12;20(2). Epub 2019 Jan 12.

Burn Center, Red Cross Hospital, 1942 LE Beverwijk, The Netherlands.

Platelet rich plasma (PRP) is blood plasma with a platelet concentration above baseline. When activated, PRP releases growth factors involved in all stages of wound healing, potentially boosting the healing process. To expand our knowledge of the effectiveness of PRP, it is crucial to know the content and composition of PRP products. Read More

J Periodontol 2019 Jan 13. Epub 2019 Jan 13.

Department of Periodontics, Government Dental College and Hospital, Mumbai.

Background: Development of autologous and recombinant growth factor/matrix combination products represent a new emerging trend in regenerative therapeutics and have gained increasing attention as a strategy to optimize tissue regeneration. The aim of the present study was to evaluate the levels of Platelet derived growth factor BB (PDGF-BB) in gingival crevicular fluid (GCF) during early healing period after the regenerative treatment of intrabony defects using beta tricalcium phosphate (β-TCP) as a bone regeneration material with either platelet rich fibrin (PRF) membrane or collagen membrane (CM) treated with recombinant human PDGF-BB (rhPDGF-BB).

Methods: Twenty patients (13 males and 7 females) with chronic periodontitis participated in this prospective, randomized clinical and biochemical study. Read More

Iran J Basic Med Sci 2018 Dec;21(12):1198-1199

Department of Pharmacology, Abadan School of Medical Sciences, Abadan, Iran.

Wound healing is a natural response to restore the injured tissue to normal. Wound healing is also complicated process involving different cellular, molecular and biochemical mechanisms and various types of cytokines and growth factors. Calcium channel blockers belong to cardiovascular medicine and administrated to treatment of hypertension, angina and cardiac arrhythmia because of vasodilatory effect. Read More

Saudi Pharm J 2019 Jan 20;27(1):33-40. Epub 2018 Jul 20.

Siriraj Center of Research Excellence for Molecular Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Wound healing is the curative process of tissue injury, composed of three phases: the inflammatory phase, proliferative phase, followed by the maturation cum remodeling phase. Various treatment options were previously depicted for wound healing, however a treatment that accelerates these phases would be highly valuable. Platelet aggregation at the bleeding vessels and release of various growth factors are the most promising factors that stimulates the wound healing progress. Read More

Growth Factors 2019 Jan 9:1-7. Epub 2019 Jan 9.

d Department of Periodontology, Faculty of Dentistry , Recep Tayyip Erdogan University , Rize , Turkey.

The present study evaluates the effects of leukocyte-platelet-rich fibrin (L-PRF) combined with open flap debridement (OFD) on clinical parameters and growth factors levels (GFL) in chronic periodontitis (CP) patients. This trial was registered at clinicaltrials.gov as NCT02594605. Read More

Stem Cells Transl Med 2019 Jan 9. Epub 2019 Jan 9.

The Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, People's Republic of China.

Systematic abnormalities cause several complications in diabetes patients. Impaired wound healing is a serious complication that leads to severe foot ulcer and amputation. Mesenchymal stem cells (MSCs) have been considered a promising strategy for promoting wound healing due to their paracrine function. Read More

J Immunol Res 2018 28;2018:5196023. Epub 2018 Nov 28.

"Carol Davila" University of Medicine and Pharmacy, 37 Dionisie Lupu, 020021 Bucharest, Romania.

Wound healing is a complex biologic process evolving in three phases: inflammation, proliferation, and tissue remodeling controlled by numerous growth factors and cytokines. Oral mucosa wounds heal with significantly less important scars with less numerous macrophages and mast cells and more numerous myofibroblasts than cutaneous counterparts. We analyzed 32 cutaneous and 32 oral mucosa scars for TGFbeta1, TGFbeta2, TGFbeta3, TNFalpha, PDGF BB and FGF1 expression in mesenchymal cells, endothelial cells, macrophages, and multinucleated giant cells. Read More

Cell Death Dis 2019 Jan 8;10(1):18. Epub 2019 Jan 8.

Department of Hepatology, Kanazawa Medical University, Uchinada, Ishikawa, 920-0293, Japan.

Hepatic fibrosis is marked by excessive synthesis and deposition of connective tissue proteins, especially interstitial collagens in the extracellular matrix of the liver. It is a result of an abnormal wound healing in response to chronic liver injury from various causes such as ethanol, viruses, toxins, drugs, or cholestasis. The chronic stimuli involved in the initiation of fibrosis leads to oxidative stress and generation of reactive oxygen species that serve as mediators of molecular events involved in the pathogenesis of hepatic fibrosis. Read More

J Vasc Surg Venous Lymphat Disord 2019 Jan 6. Epub 2019 Jan 6.

Division of Vascular Surgery, Department of Surgery, University of Maryland School of Medicine and Baltimore Veterans Administration Medical Center, Baltimore, Md. Electronic address:

Objective: Chronic venous leg ulcers (VLUs) affect up to 2% of the general population, resulting in a significant socioeconomic burden. Placental tissue that contains mesenchymal stem cells and active growth factors has been shown to be beneficial in healing of chronic wounds. We compared the efficacy of a human viable wound matrix (hVWM) of cryopreserved placental tissue for the treatment of refractory VLUs with standard therapy. Read More

Front Physiol 2018 14;9:1794. Epub 2018 Dec 14.

Dorothy M. Davis Heart & Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, United States.

Although cell survival post-transplantation is very low, emerging evidence using stem cell therapy for myocardial repair points toward a primary role of paracrine signaling mechanisms as the basis for improved cardiac function, decreased fibrosis, and increased angiogenesis. Recent studies have demonstrated that extracellular vesicles (EVs) such as exosomes secreted by stem cells stimulate angiogenesis, provide cytoprotection, and modulate apoptosis. However, the angiogenic potential of EVs secreted from human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM), a terminally differentiated cell type, has not been elucidated yet. Read More

Exp Cell Res 2019 Jan 2. Epub 2019 Jan 2.

Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA; Department of Medicine, University of Virginia, Charlottesville, VA, USA; Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, USA. Electronic address:

Regenerating cardiac muscle lost during a heart attack is a topic of broad interest and enormous potential impact. One promising approach is to regenerate or re-engineer new myocardium in situ, at the site of damage, by injecting cells, growth factors, and other materials, or by reprogramming aspects of the normal wound healing process. A wide variety of strategies have been explored, from promoting angiogenesis to injection of a variety of different progenitor cell types, to re-engineering resident cells to produce key growth factors or even transdifferentiate into myocytes. Read More

J Cell Physiol 2019 Jan 4. Epub 2019 Jan 4.

Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina.

An important step in many pathological conditions, particularly tissue and organ fibrosis, is the conversion of relatively quiescent cells into active myofibroblasts. These are highly specialized cells that participate in normal wound healing but also contribute to pathogenesis. These cells possess characteristics of smooth muscle cells and fibroblasts, have enhanced synthetic activity secreting abundant extracellular matrix components, cytokines, and growth factors, and are capable of generating contractile force. Read More

PLoS One 2019 4;14(1):e0210301. Epub 2019 Jan 4.

Departament de Ciències Fisiològiques, Universitat de Barcelona, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.

Background: After bone resorption, ions and degraded organic components are co-released into the extracellular space. Ions and growth factors, although different in their biological nature, induce a common and coordinated chemotactic effect. Conditioned media has been used successfully in bone regeneration by promoting endogenous cell recruitment. Read More

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2018 Dec;40(6):822-826

Department of Burns,the Second Affiliated Hospital,Kunming Medical University, Burn Institute of Yunnan Province,Kunming 650101,China.

Hepatocyte growth factor (HGF) is a multifunctional cytokine that is related to many diseases. HGF mainly contributes to cell migration,proliferation,and survival and regulates vascular angiogenesis,matrix deposition,and degradation of wound healing. HGF also promotes wound reepithelialization and reduces scar formation. Read More

J Exp Clin Cancer Res 2019 Jan 3;38(1). Epub 2019 Jan 3.

School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Background: Glioblastomas multiforme (GBM) is the most devastating primary intracranial malignancy lacking effective clinical treatments. Notch2 has been established to be a prognostic marker and probably involved in GBM malignant progression. N-acetylcysteine (NAC), a precursor of intracellular glutathione (GSH), has been widely implicated in prevention and therapy of several cancers. Read More

Stem Cell Res Ther 2019 Jan 3;10(1). Epub 2019 Jan 3.

Department of Medical Research, Mackay Memorial Hospital, No. 45, Minsheng Rd., Tamsui District, New Taipei City, 25160, Taiwan.

Background: Tendon stem/progenitor cells (TSPC) exhibit a low proliferative response to heal tendon injury, leading to limited regeneration outcomes. Exogenous growth factors that activate TSPC proliferation have emerged as a promising approach for treatment. Here, we evaluated the pigment epithelial-derived factor (PEDF)-derived short peptide (PSP; 29-mer) for treating acute tendon injury and to determine the timing and anatomical features of CD146- and necleostemin-positive TSPC in the tendon healing process. Read More

ACS Appl Mater Interfaces 2019 Jan 3. Epub 2019 Jan 3.

Expediting the wound healing process is critical for patients chronically ill from non-healing wounds and diseases such as hemophilia or diabetes or who have suffered trauma including easily infected open wounds. FDA-approved external tissue sealants include the topical application of fibrin gels, which can be 500 times denser than natural fibrin clots. With lower clot porosity and higher polymerization rates than physiologically formed fibrin clots, the commercial gels quickly stop blood loss, but impede the later clot degradation kinetics and thus retard tissue-healing rates. Read More

Growth Factors 2019 Jan 2:1-17. Epub 2019 Jan 2.

c Department of Pediatric Surgery, Tongji Hospital, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , China.

Pulmonary inflammation and progressive lung destruction are the major causes of chronic obstructive pulmonary disease (COPD), resulting in emphysema and irreversible pulmonary dysfunction. Heparin-binding EGF-like growth factor (HB-EGF), is known to play a protective role in the process of various inflammatory diseases. However, its effect on COPD is poorly understood. Read More

Eur J Clin Invest 2019 Jan 1:e13067. Epub 2019 Jan 1.

Department of Metabolic Diseases, Jagiellonian University Medical College Krakow, Poland.

Background: Diabetes and its complications constitute a rising medical challenge. Special attention should be given to diabetic foot syndrome (DFS) due to its high rate of associated amputation and mortality. Negative pressure wound therapy (NPWT) is a frequently used supportive modality in a diabetic foot with ulcerations (DFUs). Read More

J Am Coll Clin Wound Spec 2017 28;9(1-3):39-45. Epub 2018 Apr 28.

Arak University of Medical Sciences, Faculty of Medicine Arak, Iran.

The global prevalence of diabetes is estimated to be 200 million people, and it is likely to increase to 333 million people by 2025. Different cells, are known to participate in three main phases of wound healing. Omega-3 fatty acids influence cytokines and growth factors which affects the presence of inflammatory cells in wound area as well, but how this event specifically influences the role of fibroblasts, macrophages and angiogenesis in wound healing is not obviously understood. Read More

Zhonghua Shao Shang Za Zhi 2018 Dec;34(12):910-913

Department of Burns and Plastic Surgery, the General Hospital of PLA Tibet Military Area Command, Lhasa 850000, China.

Autologous platelet-rich plasma (PRP) is plasma with high concentration of platelet extracted from autologous blood. After activation, growth factors involved in wound healing are released from PRP. Current clinical investigations have demonstrated that the application of PRP seems to enhance the clinical outcome of plastic surgery, oral implantology, maxillofacial region and bone repair, and cardio-thoracic surgery. Read More

Zhonghua Shao Shang Za Zhi 2018 Dec;34(12):864-867

Department of Burns, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China.

Wound healing is a complex and sequential biological process involving various cells and factors under body's regulation. Appropriate interventions play positive roles in promoting effective wound healing and improving healing quality. In the clinical practice, there are many new instruments, dressings, and drugs developed for wound care, including antibacterial dressings, wet dressings, precise debridement, negative pressure wound therapy, cytokines/growth factors, and dermal substitutes, which provide revolutionary means for wound treatment. Read More

Oxid Med Cell Longev 2018 18;2018:5286785. Epub 2018 Nov 18.

Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Wound healing is a complex multiphase process which can be hampered by many factors including impaired local circulation, hypoxia, infection, malnutrition, immunosuppression, and metabolic dysregulation in diabetes. Redox dysregulation is a common feature of many skin diseases demonstrated by virtually all cell types in the skin with overproduction of reactive oxygen and nitrogen species. The objective of this study was to characterize the redox environment in wound fluids and sera from patients suffering from chronic leg ulcers ( = 19) and acute wounds (bulla fluids from second degree burns; = 11) with serum data also compared to those from healthy volunteers ( = 7). Read More

Wound Repair Regen 2018 Dec 21. Epub 2018 Dec 21.

Health Services and Chronic Diseases Research Network (REDISSEC), Spain.

Foot ulcer is a major complication of diabetes mellitus and often precedes leg amputation. Among the different methods to achieve ulcer healing, the use of platelet-rich plasma, which is rich in multiple growth factors and cytokines and may have similarities to the natural wound healing process, is gaining in popularity. A systematic review with meta-analyses was performed to evaluate the safety and clinical effectiveness of platelet-rich plasma for the treatment of diabetic foot ulcers compared to standard treatment or any other alternative therapy. Read More

Front Physiol 2018 4;9:1671. Epub 2018 Dec 4.

Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, The Center for Growth, Metabolism and Aging, The College of Life Sciences, Sichuan University, Chengdu, China.

Liver fibrosis is an abnormal wound healing response and a common consequence of chronic liver diseases from infection or alcohol/xenobiotic exposure. At the cellular level, liver fibrosis is mediated by trans-differentiation of hepatic stellate cells (HSCs), which is driven by persistent hepatic and systemic inflammation. However, impaired enterohepatic circulation and gut dysbiosis may indirectly contribute to the liver fibrogenesis. Read More

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8288-8297

Emergency Department, Shenzhen People's Hospital, the Second Medical College of Jinan University, Shenzhen, Guangdong, China.

Objective: Long noncoding RNA LINC00675 (LINC00675) seems to play an anti-oncogenic role in cancers, though its exact function remains unknown. Up to date, little is known about the role of LINC00675 in esophageal squamous cell carcinoma (ESCC). In this study, we aimed to explore the expression pattern, clinical significance and biological function of LINC00675 in ESCC. Read More

Aesthetic Plast Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Molecular Medicine and Genetics, Research Center for Molecular Medicine, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Introduction: In recent years, platelet-rich plasma (PRP) has emerged as a promising autologous biological treatment modality for the use in aesthetic and regenerative medicine. PRP is a high concentration of platelets derived from whole blood which is isolated by centrifugation to separate and concentrate platelet-containing plasma from red blood cells. PRP comprises hundreds of bioactive proteins, including growth factors, peptides, and cytokines that stimulate healing of skin and soft tissues. Read More

Am J Sports Med 2018 Dec 14:363546518814534. Epub 2018 Dec 14.

Rehabilitation Medicine Research Center, Mayo Clinic, Rochester, Minnesota, USA.

Background:: The paratenon is important for Achilles tendon healing. There is much interest in the use of exogenous growth factors (GFs) as potential agents for accelerating the healing of damaged Achilles tendons.

Purpose/hypothesis:: The present study used a rat model to study the responses of the injured Achilles tendon to GFs in the presence or absence of the paratenon. Read More

Int J Periodontics Restorative Dent 2018 Dec 14. Epub 2018 Dec 14.

Positive effects of platelet-rich fibrin (PRF) on soft tissue healing are well documented, but its role in hard-tissue healing remains contested. The present case series documents the use of PRF as the sole grafting material in periapical bone defects. PRF was prepared and condensed into the bone defects after debridement. Read More

J Periodontol 2018 Dec 14. Epub 2018 Dec 14.

Department of Conservative Dentistry and Periodontology, University Clinic of Dentistry, Medical University of Vienna, Vienna, Austria.

Background: A major mediator of angiogenesis is angiogenin, which is expressed in the early phase of healing in oral tissue engineering strategies. It is unclear how angiogenin is regulated in the periodontal tissue. The objective of this study was to reveal the regulation of angiogenin in response to hypoxia and the hypoxia mimetic agent l-mimosine in periodontal fibroblasts. Read More

Adv Healthc Mater 2018 Dec 12:e1801160. Epub 2018 Dec 12.

Department of Biosystems & Biomaterials Science and Engineering, Seoul National University, Seoul, 151-742, Republic of Korea.

Chronic tympanic membrane (TM) perforations can cause otorrhea. To date, various types of tissue engineering techniques have been applied for the regeneration of chronic TM perforations. However, the application of nanofibers with radially aligned nanostructures and the simultaneous release of growth factors have never been applied in the regeneration of chronic TM perforations. Read More

BMC Complement Altern Med 2018 Dec 12;18(1):331. Epub 2018 Dec 12.

Department of Biomedical Science and Engineering, Konkuk Institute of Technology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, South Korea.

Background: The placenta is a reservoir enriched with growth factors, hormones, cytokines and minerals. While several beneficial effects of placenta extracts on wound healing, anti-aging and anti-inflammatory responses have been reported, relatively limited mechanistic exploration has been conducted to date. Here, we provide compelling evidence of anti-inflammatory and anti-oxidative activities of porcine placenta extracts (PPE) against contact dermatitis in vivo. Read More

Regen Ther 2019 Jun 20;10:1-9. Epub 2018 Nov 20.

Department of Plastic and Reconstructive Surgery, Kansai Medical University, 2-5-1 Shin-machi, Hirakata City, Osaka, 573-1010, Japan.

Introduction: Human platelet lysate (hPL) part of the growth factor cocktail derived from human platelets, which has been applied as a cell growth supplement. The production process is easier in comparison to platelet-rich plasma; thus, hPL is now considered for use in wound healing therapy. However, methods for preserving hPL for more than several months that maintain its bioactivity must be considered, especially for chronic wound treatment. Read More

Adv Exp Med Biol 2018 ;1109:139-163

Translational Neurology Group, Department of Clinical Sciences and Wallenberg Center for Molecular Medicine, Department of Neurology, Lund University, Lund, Sweden.

The role of pericytes seems to extend beyond their known function in angiogenesis, fibrosis and wound healing, blood-brain barrier maintenance, and blood flow regulation. More and more data are currently accumulating indicating that pericytes, uniquely positioned at the interface between blood and parenchyma, secrete a large plethora of different molecules in response to microenvironmental changes. Their secretome is tissue-specific and stimulus-specific and includes pro- and anti-inflammatory factors, growth factors, and extracellular matrix as well as microvesicles suggesting the important role of pericytes in the regulation of immune response and immune evasion of tumors. Read More

Adv Exp Med Biol 2018 ;1109:111-124

Department of Chemical and Biomolecular Engineering, Institute for NanoBioTechnology, and the Physical Sciences-Oncology Center, Johns Hopkins University, Baltimore, MD, USA.

Pericytes wrap blood microvessels and are believed to play important roles in vascular morphogenesis, maturation, and stability. In addition, pericytes have emerged as candidates for targeting cancer growth and for wound healing. In order to model these processes and test new therapies, it is desirable to have a reliable, scalable source of pericytes. Read More

J Appl Oral Sci 2018 Dec 10;27:e20180015. Epub 2018 Dec 10.

Gazi University, Faculty of Dentistry, Department of Oral Pathology, Ankara, Turkey.

Objectives: In this study, the effects of ozonetherapy on secondary wound healing were evaluated histologically and immuno-histochemically.

Material And Methods: Material and Methods: 8 healthy pigs were used in this study. Six wounds with 10 mm in diameter were created through the punch technique on the palatinal gingiva of each pig. Read More

Cancer Manag Res 2018 20;10:5991-6001. Epub 2018 Nov 20.

Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China,

Purpose: We previously found the involvement of human herpesvirus 6 (HHV-6) infection in the pathogenesis of glioma. U94/rep, encoded by HHV-6, has been identified to play a vital role in viral gene expression and latency. Recent studies have shown its inhibition of angiogenesis and tumorigenesis in endothelial cells and prostate cancer cell line PC3, respectively. Read More

Rom J Morphol Embryol 2018 ;59(3):655-662

Laboratory of Mesenchymal Stromal Progenitor Cells Therapy, Department of Regenerative Medicine, "Nicolae Simionescu" Institute of Cellular Biology and Pathology, Bucharest, Romania;

In modern society, the healing of chronic wounds is still a major cause of discomfort for the patients and a financial burden for the care system. Current approaches use either organic tissue-engineered skin substitutes or stem cells based therapy. It has been shown that mesenchymal stem cells (MSCs) are able to improve the wound healing process by secreting factors with anti-inflammatory, anti-fibrotic and pro-angiogenic activities either as soluble molecules (growth factors, cytokines) or encapsulated within membrane vesicles (microparticles, exosomes). Read More

J Surg Res 2019 Feb 11;234:190-201. Epub 2018 Oct 11.

Department of Plastic and Reconstructive Surgery, Kansai Medical University, Hirakata City, Osaka, Japan.

Background: The efficacy of a gelatin hydrogel (GH) sheet impregnated with platelet-rich plasma in full-thickness wound healing has been reported. Human platelet lysate is another potential natural product for use in wound healing. The present study examined the effects of a GH sheet impregnated with concentrated freeze-dried platelet lysate on wound healing after storage for 9 mo. Read More

Drug Deliv Transl Res 2019 Feb;9(1):227-239

School of Pharmacy, Jinzhou Medical University, Jinzhou, 121000, People's Republic of China.

Diabetic wounds as chronic wounds represent a severe, persistent complication of diabetes and, in the most extreme cases, can lead to amputation. Two critical and unfavorable factors affecting diabetic wound healing are sustained bacterial-induced chronic inflammation and disrupted vascularization. In this paper, we presented a novel, pH-responsive calcium alginate hydrogel laden with protamine nanoparticles and hyaluronan oligosaccharides, and explored its potential for accelerating diabetic wound healing. Read More

J Med Genet 2018 Dec 5. Epub 2018 Dec 5.

The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben Gurion University, Beer Sheva, Israel.

Background: Dilated cardiomyopathy (DCM) is a primary myocardial disease leading to contractile dysfunction, progressive heart failure and excessive risk of sudden cardiac death. Around half of DCM cases are idiopathic, and genetic factors seem to play an important role.

Aim: We investigated a possible genetic cause of DCM in two consanguineous children from a Bedouin family. Read More

Clin Hemorheol Microcirc 2018 ;70(3):267-280

Department of Cardiac Surgery, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Herzzentrum Dresden, Germany.

Adipose tissue is not only a connective tissue but also an endocrine organ secreting adipokines like Leptin and Adiponectin, lipokines such as palmitoileic acid and extracellular vesicles. These factors and the expression of matrix remodeling enzymes impact surrounding tissues via paracrine effects. The expression of selected secretion factors and the effect of adipocyte conditioned media from four thoracal adipose tissue origins - subcutaneous, perivascular, pericardial and epicardial adipose tissues - in a fibroblast proliferation/wound healing scratch assay model were investigated. Read More

ACS Appl Mater Interfaces 2018 Dec 3. Epub 2018 Dec 3.

Improved and more rapid healing of full-thickness skin wounds remains a major clinical need. Silk fibroin (SF) is a natural protein biomaterial that has been used in skin repair. However, there has been little effort aimed at improving skin healing through tuning the hierarchical microstructure of SF-based matrices and introducing multiple physical cues. Read More

Sci Rep 2018 Nov 30;8(1):17509. Epub 2018 Nov 30.

Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, 22908, United States.

Capable of mediating efficient transfection and protein production without eliciting innate immune responses, chemically modified mRNA holds great potential to produce paracrine factors at a physiologically beneficial level, in a spatiotemporally controlled manner, and with low toxicity. Although highly promising in cardiovascular medicine and wound healing, effects of this emerging therapeutic on the microvasculature and its bioactivity in disease settings remain poorly understood. Here, we longitudinally and comprehensively characterize microvascular responses to AZD8601, a modified mRNA encoding vascular endothelial growth factor A (VEGF-A), in vivo. Read More

Int J Low Extrem Wounds 2018 Dec 3;17(4):301-303. Epub 2018 Dec 3.

1 College of Life Sciences, PLA General Hospital, PLA Medical College, Beijing, People's Republic of China.

In recent years, wound repair, especially chronic and refractory wounds, is still a growing worldwide health problem that concerns the physical and mental health of patients and the productivity of society as a whole. In many developed countries and developing countries, such as China, rapid economic growth, negative lifestyle changes (such as increased dietary fat intake and reduced physical activity), and increasingly serious aging problems have led to more and more refractory wounds caused by chronic diseases, such as diabetes and microvascular diseases. There is a clear and orderly stage in the process of wound healing, and the malfunction of any step will lead to poor healing effect. Read More

Acta Cir Bras 2018 Nov;33(11):1000-1015

MD, Postgraduate Program in Surgical Science, Department of Surgery, School of Medicine, UFRJ, Rio de Janeiro-RJ, Brazil. Manuscript writing, critical revision, final approval.

Purpose: To evaluate the effects and mechanisms of andiroba-based emulsion (ABE) topical treatment on full-thickness cutaneous wounds in rats.

Methods: The wounds were harvested on days 3, 7, 15, and 20 post-surgery. Wound contraction rate, quantitative immunohistochemistry [macrophages, myofibroblasts, capillaries, collagens (col) I and III, transforming growth factor β3β (TGFβ3)], and tensile strength were assessed. Read More

Rev Esp Enferm Dig 2018 Dec 3;111. Epub 2018 Dec 3.

Department of Gastroenterology, Zhongshan Hospital, Fudan University, China.

Background And Aims: pathological angiogenesis plays an important role in the progression of chronic liver diseases. Asparaginyl endopeptidase (AEP) participates in tumor angiogenesis and was recently shown to be associated with liver fibrosis. This study aimed to explore the effect of AEP on liver sinusoidal endothelial cell (LSECs) angiogenesis and determine the underlying mechanism. Read More

Exp Dermatol 2018 Nov 29. Epub 2018 Nov 29.

Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.

Wounds close by keratinocytes migrating from the edge of the wound and re-epithelializing the epidermis. It has been proposed that the major stimuli for wound closure are blood-derived growth factors, chemokines and cytokines. The small GTPase R-Ras, a known integrin activator, also regulates vascular permeability during angiogenesis, and blood vessels lacking R-Ras leak plasma proteins constantly. Read More