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Dermatol Surg 2021 02;47(2):277-279

Dermatology Department, University of Connecticut Health Center, Farmington, Connecticut.

Ann Surg Treat Res 2020 Sep 27;99(3):146-152. Epub 2020 Aug 27.

Division of Colorectal Surgery, Department of Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Purpose: Minimally invasive colorectal surgery had reduced the rate of surgical site infection. The use of surgical skin adhesive bond (2-octyl cyanoacrylate) for wound closure reduces postoperative pain and provides better cosmetic effect compared to conventional sutures or staples. But role of surgical skin adhesive bond for reducing surgical site infection is unclear. Read More

Orthopedics 2020 Nov 3;43(6):e515-e522. Epub 2020 Sep 3.

The Dermabond Prineo skin closure system (Ethicon, Somerville, New Jersey) is a wound closure device that combines a 2-octyl cyanoacrylate liquid adhesive and a self-adhesive polyester mesh. Although cyanoacrylates traditionally have been associated with low rates of sensitization, allergic contact dermatitis (ACD) to Dermabond products is being increasingly reported after orthopedic surgery. The authors describe the first case series of ACD to Dermabond Prineo where patch testing confirmed the diagnosis in all patients. Read More

Iowa Orthop J 2020 ;40(1):147-151

University of Iowa Hospitals and Clinics, Department of Orthopedics and Rehabilitation, Iowa City, IA.

Background: We conducted a retrospective review of geriatric hip fractures at our institution evaluating how a change in practice to 2-octyl cyanoacrylate adhesive (Dermabond®) with polyester mesh (Prineo®) and elimination of the 2-week follow-up visit impacts quality and efficiency of care after hip fracture. Our aim was to determine the impact of simplified wound closure and extended clinical follow-up on the number of outpatient calls to nurses and wound complications.

Methods: Patients included in this assessment were aged ≥65 years who underwent surgical fixation or hip replacement for proximal femur fracture during a one-year period preceding and following the implementation of Prineo® usage in wound closure (January 1 2017 to December 31, 2018). Read More

Am J Otolaryngol 2020 Sep - Oct;41(5):102552. Epub 2020 May 28.

Department of Otolaryngology Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, NY, New York, USA.

Background: Salivary fistulas remain a significant problem in patients undergoing major head and neck reconstructive surgery. Surgical sealants have become increasingly used in cutaneous and non-cutaneous wound closure, providing a barrier to fluids/gases and promoting healing. The purpose of this study was to determine the efficacy of a common surgical sealant, 2-Octyl Cyanoacrylate (2-OCA, Dermabond®), in the prevention of salivary fistulas following free flap reconstruction of the oral cavity. Read More

Int J Urol 2020 Aug 1;27(8):670-675. Epub 2020 Jun 1.

Department of Urology, Keio University School of Medicine, Tokyo, Japan.

Objectives: To evaluate postoperative pain and esthetic outcomes in patients undergoing transumbilical laparoscopic adrenalectomy with wound closure using 2-octyl cyanoacrylate.

Methods: A total of 26 patients who underwent laparoscopic adrenalectomy with the transumbilical approach and agreed to participate in this study were included. Patients were randomly divided into two groups: the 2-octyl cyanoacrylate group (Glue group) or the non-use group (non-Glue group). Read More

Plast Reconstr Surg 2020 01;145(1):32-37

From the Division of Plastic and Reconstructive Surgery and the Department of Dermatology, Virginia Commonwealth University; and Eastern Virginia Medical School.

Skin adhesives have become standard in wound closure as alternatives to traditional sutures or as sterile occlusive dressings after surgery of all types. The literature is replete with case reports of contact dermatitis following exposure to cyanoacrylate-based adhesives, such as 2-octyl cyanoacrylate. Nonetheless, it has been the impression of the senior author and others that the incidence of allergic and/or contact dermatitis is much higher than commonly considered. Read More

Int Wound J 2020 Apr 19;17(2):449-454. Epub 2019 Dec 19.

A21 Surgery Department, Charles Nicolle Hospital, Faculty of medicine of Tunis/Tunis El Manar University, Tunis, Tunisia.

Tissue adhesives have gained increasing use as a possible method of wound closure. We compared the use of 2-octyl cyanoacrylate (OCA) or subcuticular suture in incisions sutures for the closure of laparoscopic cholecystectomy port incisions. A prospective randomised controlled trial was performed. Read More

J Vasc Access 2020 May 9;21(3):293-299. Epub 2019 Sep 9.

NAMSA, Brooklyn Park, MN, USA.

Introduction: Over one billion intravascular devices are used worldwide, annually. Due to the associated complications with these devices, the development of a reliable yet cost-effective securement technique is extremely important. The purpose of this study is to demonstrate the strength of a novel catheter securement cyanoacrylate for securing peripheral venous catheters, central venous catheters, peripherally inserted central catheters, and all other intravascular catheter types. Read More

Dermatol Surg 2020 05;46(5):628-634

Department of Dermatology, University of California, Davis, School of Medicine, Sacramento, California.

Background: Although the use of 2-octylcyanoacrylate (OCA) in cutaneous surgery offers increased efficiency, there is scant data comparing scar outcomes achieved with OCA versus 5-0 fast-absorbing gut suture (FG).

Objective: To compare scar cosmesis achieved with OCA versus FG for surgical wound closure.

Materials And Methods: A total of 44 patients with postoperative defects of at least 3 cm were included. Read More

Obstet Gynecol 2019 08;134(2):295-301

Departments of Obstetrics and Gynecology and Biostatistics and Research Informatics, NorthShore University HealthSystem, Evanston, and the Department of Obstetrics and Gynecology, University of Chicago, Chicago, Illinois.

Objective: To assess whether tissue adhesive after closure of Pfannenstiel incision for cesarean delivery lowers the risk of wound complications when compared with sterile strips.

Methods: In this multicenter randomized controlled trial, women undergoing cesarean delivery using Pfannenstiel skin incision were randomized to receive tissue adhesive (2-octyl cyanoacrylate) compared with sterile strips after closure of the skin incision. The primary outcome was a composite of wound complications (drainage, cellulitis, abscess, seroma, hematoma, or isolated wound separation) within 8 weeks of delivery. Read More

Ann Vasc Surg 2019 Oct 12;60:463-467. Epub 2019 Jun 12.

Department of Vascular Surgery, Metropolitan Hospital, New York Medical College, Icahn School of Medicine at Mount Sinai Medical Center, New York, NY.

Surgical site infections (SSIs) are a common source of morbidity with vascular surgery incisions, especially in the groin. Single institution case series have widely varying, but high incidences of groin wound infection after open lower extremity revascularization. Optimally, a dressing that did not require changes, had low cost, and was water resistant would be optimal in these patients. Read More

Wounds 2019 Jul 31;31(7):166-172. Epub 2019 May 31.

Adhezion Biomedical, Hudson, NC.

Objective: The purpose of this study is to introduce a wound closure testing method that reproduces a pulling or stretching force, leading to more accurate supporting data for clinicians to select the proper product when closing a low- or high-tension incision in conjunction with deep dermal sutures.

Materials And Methods: Incisions were made in the center of 70 prepared porcine skin samples. They were cleaned with isopropanol and wiped dry before applying the adhesive, as per each respective manufacturer's instructions. Read More

Surg Infect (Larchmt) 2019 Sep 30;20(6):449-452. Epub 2019 Mar 30.

1Division of Infectious Diseases, University of Kansas Health System, Kansas City, Kansas.

Despite advances in incision care and surgical dressings, surgical site infections remain a common complication. Post-operative contamination of a surgical site is believed to play a role in many of these infections. Most surgical dressings adhere to the skin with pressure-sensitive adhesives. Read More

Vet Comp Orthop Traumatol 2019 Jan 15;32(1):18-25. Epub 2019 Jan 15.

Virginia Veterinary Surgical Associates, a BluePearl Partner, Richmond, Virginia, United States.

Objective:  The main aim of this study was to evaluate the efficacy of a topical 2-octyl cyanoacrylate (2OC) tissue adhesive and an adhesive barrier dressing (BD) in minimizing the incidence of surgical site infections (SSI) in dogs undergoing a tibial plateau levelling osteotomy (TPLO).

Materials And Methods:  In a prospective clinical study, 437 client-owned dogs undergoing a TPLO as treatment for cranial cruciate ligament disease with or without concurrent patellar luxations from July 2015 to September 2016 were included. In each dog, the type of postoperative wound dressing was randomly selected as either no dressing (ND), a 2OC tissue adhesive or an adhesive BD. Read More

J Periodontol 2019 06 26;90(6):608-615. Epub 2018 Dec 26.

Department of Dental Diagnostic and Surgical Sciences, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.

Background: The purpose was to compare patient-centered outcomes, early wound healing, and postoperative complications at palatal donor area of subepithelial connective tissue grafts (CTG) between cyanoacrylates tissue adhesives and polytetrafluoroethylene (PTFE) sutures.

Methods: Thirty-six patients who required harvesting of CTG were enrolled in this randomized clinical trial and assigned to one of two groups. In the "suture" group, wound closure was achieved with standardized continuous interlocking 6-0 PTFE sutures, while in the "cyanoacrylate" group, a high viscosity blend of n-butyl and 2-octyl cyanoacrylate was applied until hemostasis was achieved. Read More

Vet Surg 2018 Nov 10;47(8):1087-1093. Epub 2018 Oct 10.

Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.

Objective: To compare cutaneous wound closure with mesh and 2-octyl cyanoacrylate (MOC) vs an intradermal suture pattern (ISP) in terms of time of application and biomechanical properties.

Sample Population: Experimental study with 12 female beagle dogs.

Methods: A skin incision was created from the xiphoid to the pubis as part of an ovariohysterectomy; the linea alba and subcutaneous tissue were closed routinely. Read More

J Am Acad Dermatol 2019 Aug 5;81(2):e37-e38. Epub 2018 Oct 5.

University of California, San Diego, California.

Am J Emerg Med 2019 04 29;37(4):788-789. Epub 2018 Aug 29.

College of Engineering and Applied Sciences, Stony Brook University, United States of America.

Injury 2018 Oct 17;49(10):1942-1946. Epub 2018 Aug 17.

Department of Orthopaedic Surgery, Korea University Guro Hospital, 148 Gurodong-ro, Guro-gu, Seoul, 08308, Republic of Korea. Electronic address:

Meticulous skin closure is required to avoid wound problems after Achilles tendon surgery. The purpose of our study was to compare postoperative complication rate, operation time, clinical outcome and patient satisfaction with the wound among two topical skin adhesives (2-octyl cyanoacrylate and n-butyl cyanoacrylate) and conventional nylon skin sutures in Achilles tendon repair surgery. We retrospectively reviewed the records 122 consecutive patients (40 patient in nylon skin suture, 43 patients in 2-octyl cyanoacrylate and 39 patients in n-butyl cyanoacrylate) who underwent surgical repair for acute Achilles tendon rupture between 2012 and 2016. Read More

Foot Ankle Int 2018 11 11;39(11):1283-1289. Epub 2018 Jul 11.

1 Department of Orthopedic Surgery, Korea University Guro Hospital, Guro-gu, Seoul, Korea.

Background: Multiple options are available for closure of incisions in ankle fracture surgery. The aim of our study was to compare postoperative outcomes between conventional simple interrupted nylon sutures and 2-octyl cyanoacrylate as a topical skin adhesive to close the incision after ankle fracture surgery.

Methods: We retrospectively reviewed the records of 367 consecutive patients (174 simple interrupted nylon suture patients and 193 topical skin adhesive patients) who underwent operative treatment for ankle fracture between 2010 and 2015. Read More

Plast Reconstr Surg 2018 10;142(4):850-856

From New York-Presbyterian Hospital/Columbia University Medical Center.

Background: An ideal wound closure system is one that is effective, consistent, and efficient. Recent studies have demonstrated the efficacy of octyl-2-cyanoacrylate and mesh (Dermabond Prineo) in the closure of surgical wounds. This study compared the use of Prineo to use of subcuticular suture closure in reduction mammaplasty. Read More

Surg Technol Int 2018 06;32:25-31

Lake Erie College of Osteopathic Medicine, Erie, Pennsylvania.

Traditionally, surgical procedures within the realm of both general and gynecological surgery employ the use of staples and interrupted sutures that run continuously with knot tying or subcuticular sutures to ensure closure of large wound incisions, subcuticular incisions, and fascial repair. However, these methods may not always be cosmetically favorable and, thus, result in an unpleasant outcome for the patient, adding to their surgery-related stress. It is, therefore, imperative that surgeons and gynecologists are aware of alternative methods of wound closure that are not only cosmetically favorable, but also ensure rapid wound recovery and infection control. Read More

Australas J Dermatol 2019 Feb 11;60(1):63-64. Epub 2018 May 11.

Department of Dermatology, University of California, San Francisco, California, USA.

J Surg Res 2018 06 22;226:166-172. Epub 2018 Feb 22.

Obstetrics, Gynecology, and Women's Health Institute, Cleveland Clinic Foundation, Cleveland, Ohio.

Background: Anastomotic leak after colorectal surgery is a significant cause of morbidity and mortality. The aim of this study was to evaluate the impact of a reinforced colo-colonic anastomosis with tissue adhesive, 2-octylcyanoacrylate (2-OCA), on the integrity of anastomotic healing as measured by anastomotic bursting pressure.

Methods: Sixty-eight female Sprague-Dawley rats underwent a rectosigmoid colon transection and a sutured end-to-end anastomosis followed by randomization to receive no further intervention or reinforcement with the tissue adhesive, 2-OCA. Read More

J Wound Care 2018 Apr;27(Sup4):S12-S22

Director, Real World Data Analytics and Research, Johnson & Johnson, Epidemiology, Medical Devices, New Brunswick, NJ, US.

Objective: To compare economic and clinical outcomes between skin staples and 2-octyl cyanoacrylate plus polymer mesh tape, Dermabond Prineo skin closure system, (SCS) among patients undergoing total knee replacement (TKR).

Method: Retrospective, observational study using the Premier Healthcare Database, which comprises hospital administrative and billing data for over 700 hospitals in the US. Patients selected for study had an elective hospital admission, with discharge occurring between January 2012 and September 2015, carrying primary ICD-9-CM procedure and diagnosis codes for TKR and osteoarthritis. Read More

Hand Surg Rehabil 2018 06 19;37(3):180-185. Epub 2018 Mar 19.

Department of hand surgery, SOS main, CCOM, university hospital of Strasbourg, FMTS, university of Strasbourg, Icube CNRS 7357, 10, avenue Baumann, 67403 Illkirch cedex, France. Electronic address:

Repair of the nail bed and plate after distal phalanx trauma remains controversial. The aim of this study was to determine whether simple approximation of the nail bed flaps maintained by tension band suture of the nail plate is sufficient to prevent nail dystrophies. Our series gathered 27 fingers in 25 patients with a mean age of 36 years. Read More

J Am Vet Med Assoc 2018 Jan;252(2):215-221

CASE DESCRIPTION 5 cats (9 eyes) were evaluated for surgical correction of bilateral eyelid agenesis. CLINICAL FINDINGS All eyes lacked > 25% of the temporal upper eyelid, and all cats had clinical signs attributable to chronic ocular exposure. Abnormalities were limited to the ocular surface in the 4 female cats, whereas the sole male cat had additional abnormalities consistent with anterior segment dysgenesis. Read More

Orthopedics 2018 Mar 22;41(2):e289-e291. Epub 2017 Sep 22.

Two-octyl cyanoacrylate is a popular skin adhesive used for closing surgical incisions. Since Food and Drug Administration approval in 1998, the few reports of adverse reactions following its use have primarily been limited to the nonorthopedic literature. The authors present a case series of contact dermatitis associated with 2-octyl cyanoacrylate following orthopedic surgery and a review of the literature on the diagnosis and treatment of this complication. Read More