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Medicine (Baltimore) 2021 Dec;100(50):e28326

Department of Orthopaedic Surgery, Chulabhorn Hospital, Bangkok, Thailand.

Abstract: 2-octyl cyanoacrylate (2OCA) is a high-viscosity medical-grade tissue adhesive that is routinely used. However, no studies have evaluated its use in musculoskeletal surgery.We enrolled 99 patients who underwent musculoskeletal surgery. Read More

Proc (Bayl Univ Med Cent) 2021 15;34(6):736-738. Epub 2021 Jun 15.

Division of Maxillofacial Oncology and Reconstructive Surgery, John Peter Smith Health Network , Fort Worth , Texas.

Tissue adhesives are commonly used for skin closure in both surgical and nonsurgical specialties. Although they are very well tolerated, tissue adhesives can induce a localized allergic response in 0.5% to 14% of patients. Read More

J Orthop Surg Res 2021 Oct 24;16(1):636. Epub 2021 Oct 24.

Department of Orthopedic Surgery, Chonnam National University Medical School and Hospital, 42 Jebongro, Donggu, Gwangju, 61469, Republic of Korea.

Background: Adhesive skin materials have increasingly been used in orthopedic surgery. We aimed to compare the efficacy and safety of skin adhesive (2-octyl cyanoacrylate and polymer mesh, Dermabond Prineo) and interrupted polypropylene sutures for wound closure in patients undergoing total ankle arthroplasty (TAA).

Methods: We prospectively enrolled 107 consecutive patients (108 ankles) undergoing TAA and divided them into two groups: skin adhesive group (36 ankles) and suture group (72 ankles). Read More

J Biomed Mater Res B Appl Biomater 2022 03 1;110(3):660-667. Epub 2021 Oct 1.

Nanoelectronics Laboratory, Department of Electrical Engineering and Computer Science, University of Cincinnati, Cincinnati, Ohio, USA.

Cerebral spinal fluid (CSF) leakage is a major postoperative complication requiring surgical intervention, resulting in prolonged healing and higher costs. Biocompatible polymers, such as cyanoacrylates, are currently used as tissue adhesives for closing surgical defects and incisions. Coupling these polymers with nanofiber technology shows promising results for generating nanofibers used in wound care, tissue engineering, and drug delivery. Read More

J Arthroplasty 2021 09 3;36(9):3141-3147. Epub 2021 May 3.

Department of Orthopedic Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Background: The 2-octyl cyanoacrylate topical adhesive with flexible self-adhesive polyester mesh (Dermabond Prineo) is becoming widely used in many surgical fields. However, no prior studies have tested the efficacy and safety of this topical adhesive compared with subcuticular suture in the same patient. The purpose of this study was to compare the efficacy and safety between Dermabond Prineo and subcuticular suture for skin closure in patients undergoing same-day bilateral total knee arthroplasties (TKAs). Read More

Medicine (Baltimore) 2021 May;100(20):e26053

Department of Orthopedic Surgery, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Republic of Korea.

Abstract: Skin adhesives are used to close clean surgical wounds. We aimed to investigate the incidence of skin adhesive-related contact dermatitis and the characteristics that differentiate it from a surgical site infection.We retrospectively analyzed patients whose surgical wound was closed using a liquid skin adhesive (Dermabond Prineo skin closure system, Ethicon, NJ) by a single surgeon between March 2018 and June 2020. Read More

Sci Rep 2021 04 20;11(1):8546. Epub 2021 Apr 20.

Department of Sensory Trauma, United States Army Institute of Surgical Research, Fort Sam Houston, TX, 78234, USA.

Open-globe injuries have poor visual outcomes and have increased in frequency. The current standard of care is inadequate, and a therapeutic is needed to stabilize the injury until an ophthalmic specialist is reached. Unfortunately, current models or test platforms for open-globe injuries are insufficient. Read More

Foot Ankle Int 2021 09 19;42(9):1106-1114. Epub 2021 Apr 19.

North Sydney Orthopaedic and Sports Medicine Centre, Wollstonecraft, Australia.

Background: There are many options for incision closure in forefoot surgery. The aim of this study was to compare topical skin adhesive (2-octyl-cyanoacrylate) to simple interrupted nylon sutures.

Methods: A prospective randomized controlled trial comparing topical skin adhesive (TSA) and nylon sutures (NSs) for elective open forefoot surgery. Read More

J Oral Maxillofac Surg 2021 07 28;79(7):1540-1548. Epub 2021 Jan 28.

Professor, Department of Oral and Maxillofacial Surgery, College of Medicine, University of Lagos, Idi - Araba, Lagos, Nigeria.

Purpose: Comparative evidence of the usefulness of octyl-2-cyanoacrylate tissue adhesive in cleft lip epidermal skin closure especially in Africans is still lacking. This study aimed to compare the outcome of wound healing after the use of Dermabond tissue adhesive and 5/0 Prolene sutures in cleft lip repair.

Methods: This was a prospective randomized controlled clinical study. Read More

Dermatol Surg 2021 02;47(2):277-279

Dermatology Department, University of Connecticut Health Center, Farmington, Connecticut.

J Orthop Surg Res 2020 Oct 10;15(1):467. Epub 2020 Oct 10.

Department of Orthopedic Surgery, The First Hospital of Jilin University, Changchun, Jilin, 130021, China.

Background: Whether using tissue adhesive alone after subcutaneous suture can close the skin incision with safety as well as cosmetic appearance after total hip arthroplasty was not clear.

Methods: A prospective study was conducted. The same surgical methods were consistent throughout the entire study. Read More

Hand Surg Rehabil 2020 12 9;39(6):550-555. Epub 2020 Sep 9.

Service de Chirurgie Orthopédique Infantile, Hôpital Lapeyronie, CHU Montpellier, Université de Montpellier, 191, Avenue du Doyen Gaston Giraud, 34925 Montpellier Cedex 5, France. Electronic address:

The main objective of this study was to compare the medium-term results of nail bed repair in children using glue (2-octylcyanoacrylate) versus absorbable sutures. The secondary objective was to compare the results of treatment in the emergency room versus the operating room. This retrospective review of 74 fingertip nail bed lacerations (68 children) evaluated the appearance and pain at the last follow-up visit (minimum of 1 year), and the operating time. Read More

Ann Surg Treat Res 2020 Sep 27;99(3):146-152. Epub 2020 Aug 27.

Division of Colorectal Surgery, Department of Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Purpose: Minimally invasive colorectal surgery had reduced the rate of surgical site infection. The use of surgical skin adhesive bond (2-octyl cyanoacrylate) for wound closure reduces postoperative pain and provides better cosmetic effect compared to conventional sutures or staples. But role of surgical skin adhesive bond for reducing surgical site infection is unclear. Read More

Orthopedics 2020 Nov 3;43(6):e515-e522. Epub 2020 Sep 3.

The Dermabond Prineo skin closure system (Ethicon, Somerville, New Jersey) is a wound closure device that combines a 2-octyl cyanoacrylate liquid adhesive and a self-adhesive polyester mesh. Although cyanoacrylates traditionally have been associated with low rates of sensitization, allergic contact dermatitis (ACD) to Dermabond products is being increasingly reported after orthopedic surgery. The authors describe the first case series of ACD to Dermabond Prineo where patch testing confirmed the diagnosis in all patients. Read More

Iowa Orthop J 2020 ;40(1):147-151

University of Iowa Hospitals and Clinics, Department of Orthopedics and Rehabilitation, Iowa City, IA.

Background: We conducted a retrospective review of geriatric hip fractures at our institution evaluating how a change in practice to 2-octyl cyanoacrylate adhesive (Dermabond®) with polyester mesh (Prineo®) and elimination of the 2-week follow-up visit impacts quality and efficiency of care after hip fracture. Our aim was to determine the impact of simplified wound closure and extended clinical follow-up on the number of outpatient calls to nurses and wound complications.

Methods: Patients included in this assessment were aged ≥65 years who underwent surgical fixation or hip replacement for proximal femur fracture during a one-year period preceding and following the implementation of Prineo® usage in wound closure (January 1 2017 to December 31, 2018). Read More

Wound Manag Prev 2020 07;66(7):33-38

Division of Plastic Surgery, University of Mississippi Medical Center, Jackson, Mississippi.

Os styloideum is an accessory wrist bone at the base of the second and third metacarpals. Similar to metacarpal bossing, chronic pain secondary to the development of osteoarthritis and tendon irritation is common. Conservative management consists of splinting and steroid injections, with surgical resection being the definitive treatment. Read More

Am J Otolaryngol 2020 Sep - Oct;41(5):102552. Epub 2020 May 28.

Department of Otolaryngology Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, NY, New York, USA.

Background: Salivary fistulas remain a significant problem in patients undergoing major head and neck reconstructive surgery. Surgical sealants have become increasingly used in cutaneous and non-cutaneous wound closure, providing a barrier to fluids/gases and promoting healing. The purpose of this study was to determine the efficacy of a common surgical sealant, 2-Octyl Cyanoacrylate (2-OCA, Dermabond®), in the prevention of salivary fistulas following free flap reconstruction of the oral cavity. Read More

Int J Urol 2020 Aug 1;27(8):670-675. Epub 2020 Jun 1.

Department of Urology, Keio University School of Medicine, Tokyo, Japan.

Objectives: To evaluate postoperative pain and esthetic outcomes in patients undergoing transumbilical laparoscopic adrenalectomy with wound closure using 2-octyl cyanoacrylate.

Methods: A total of 26 patients who underwent laparoscopic adrenalectomy with the transumbilical approach and agreed to participate in this study were included. Patients were randomly divided into two groups: the 2-octyl cyanoacrylate group (Glue group) or the non-use group (non-Glue group). Read More

J Emerg Nurs 2020 Sep 12;46(5):693-697. Epub 2020 May 12.

Surg Infect (Larchmt) 2020 Jun 17;21(5):472. Epub 2020 Jan 17.

Department of Plastic and Reconstructive Surgery, Southmead Hospital, Bristol, United Kingdom.

Plast Reconstr Surg 2020 01;145(1):32-37

From the Division of Plastic and Reconstructive Surgery and the Department of Dermatology, Virginia Commonwealth University; and Eastern Virginia Medical School.

Skin adhesives have become standard in wound closure as alternatives to traditional sutures or as sterile occlusive dressings after surgery of all types. The literature is replete with case reports of contact dermatitis following exposure to cyanoacrylate-based adhesives, such as 2-octyl cyanoacrylate. Nonetheless, it has been the impression of the senior author and others that the incidence of allergic and/or contact dermatitis is much higher than commonly considered. Read More

Int Wound J 2020 Apr 19;17(2):449-454. Epub 2019 Dec 19.

A21 Surgery Department, Charles Nicolle Hospital, Faculty of medicine of Tunis/Tunis El Manar University, Tunis, Tunisia.

Tissue adhesives have gained increasing use as a possible method of wound closure. We compared the use of 2-octyl cyanoacrylate (OCA) or subcuticular suture in incisions sutures for the closure of laparoscopic cholecystectomy port incisions. A prospective randomised controlled trial was performed. Read More

J Vasc Access 2020 May 9;21(3):293-299. Epub 2019 Sep 9.

NAMSA, Brooklyn Park, MN, USA.

Introduction: Over one billion intravascular devices are used worldwide, annually. Due to the associated complications with these devices, the development of a reliable yet cost-effective securement technique is extremely important. The purpose of this study is to demonstrate the strength of a novel catheter securement cyanoacrylate for securing peripheral venous catheters, central venous catheters, peripherally inserted central catheters, and all other intravascular catheter types. Read More

Dermatol Surg 2020 05;46(5):628-634

Department of Dermatology, University of California, Davis, School of Medicine, Sacramento, California.

Background: Although the use of 2-octylcyanoacrylate (OCA) in cutaneous surgery offers increased efficiency, there is scant data comparing scar outcomes achieved with OCA versus 5-0 fast-absorbing gut suture (FG).

Objective: To compare scar cosmesis achieved with OCA versus FG for surgical wound closure.

Materials And Methods: A total of 44 patients with postoperative defects of at least 3 cm were included. Read More

Obstet Gynecol 2019 08;134(2):295-301

Departments of Obstetrics and Gynecology and Biostatistics and Research Informatics, NorthShore University HealthSystem, Evanston, and the Department of Obstetrics and Gynecology, University of Chicago, Chicago, Illinois.

Objective: To assess whether tissue adhesive after closure of Pfannenstiel incision for cesarean delivery lowers the risk of wound complications when compared with sterile strips.

Methods: In this multicenter randomized controlled trial, women undergoing cesarean delivery using Pfannenstiel skin incision were randomized to receive tissue adhesive (2-octyl cyanoacrylate) compared with sterile strips after closure of the skin incision. The primary outcome was a composite of wound complications (drainage, cellulitis, abscess, seroma, hematoma, or isolated wound separation) within 8 weeks of delivery. Read More

Ann Vasc Surg 2019 Oct 12;60:463-467. Epub 2019 Jun 12.

Department of Vascular Surgery, Metropolitan Hospital, New York Medical College, Icahn School of Medicine at Mount Sinai Medical Center, New York, NY.

Surgical site infections (SSIs) are a common source of morbidity with vascular surgery incisions, especially in the groin. Single institution case series have widely varying, but high incidences of groin wound infection after open lower extremity revascularization. Optimally, a dressing that did not require changes, had low cost, and was water resistant would be optimal in these patients. Read More

Wounds 2019 Jul 31;31(7):166-172. Epub 2019 May 31.

Adhezion Biomedical, Hudson, NC.

Objective: The purpose of this study is to introduce a wound closure testing method that reproduces a pulling or stretching force, leading to more accurate supporting data for clinicians to select the proper product when closing a low- or high-tension incision in conjunction with deep dermal sutures.

Materials And Methods: Incisions were made in the center of 70 prepared porcine skin samples. They were cleaned with isopropanol and wiped dry before applying the adhesive, as per each respective manufacturer's instructions. Read More

Surg Infect (Larchmt) 2019 Sep 30;20(6):449-452. Epub 2019 Mar 30.

1Division of Infectious Diseases, University of Kansas Health System, Kansas City, Kansas.

Despite advances in incision care and surgical dressings, surgical site infections remain a common complication. Post-operative contamination of a surgical site is believed to play a role in many of these infections. Most surgical dressings adhere to the skin with pressure-sensitive adhesives. Read More

Vet Comp Orthop Traumatol 2019 Jan 15;32(1):18-25. Epub 2019 Jan 15.

Virginia Veterinary Surgical Associates, a BluePearl Partner, Richmond, Virginia, United States.

Objective:  The main aim of this study was to evaluate the efficacy of a topical 2-octyl cyanoacrylate (2OC) tissue adhesive and an adhesive barrier dressing (BD) in minimizing the incidence of surgical site infections (SSI) in dogs undergoing a tibial plateau levelling osteotomy (TPLO).

Materials And Methods:  In a prospective clinical study, 437 client-owned dogs undergoing a TPLO as treatment for cranial cruciate ligament disease with or without concurrent patellar luxations from July 2015 to September 2016 were included. In each dog, the type of postoperative wound dressing was randomly selected as either no dressing (ND), a 2OC tissue adhesive or an adhesive BD. Read More

J Periodontol 2019 06 26;90(6):608-615. Epub 2018 Dec 26.

Department of Dental Diagnostic and Surgical Sciences, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.

Background: The purpose was to compare patient-centered outcomes, early wound healing, and postoperative complications at palatal donor area of subepithelial connective tissue grafts (CTG) between cyanoacrylates tissue adhesives and polytetrafluoroethylene (PTFE) sutures.

Methods: Thirty-six patients who required harvesting of CTG were enrolled in this randomized clinical trial and assigned to one of two groups. In the "suture" group, wound closure was achieved with standardized continuous interlocking 6-0 PTFE sutures, while in the "cyanoacrylate" group, a high viscosity blend of n-butyl and 2-octyl cyanoacrylate was applied until hemostasis was achieved. Read More