565 results match your criteria Women's Health and Epilepsy


General side effects and challenges associated with anti-epilepsy medication: A review of related literature.

Afr J Prim Health Care Fam Med 2020 Jun 30;12(1):e1-e5. Epub 2020 Jun 30.

Department of Child Sensitive Social Policies, Faculty of Social and Gender Transformative Sciences, Women's University in Africa, Harare,.

Background: This study is coming against the background of people with epilepsy who are abandoning anti-epilepsy medication in developing countries, such as Zimbabwe.

Aim: The aim of this article was therefore to review the general side effects and challenges associated with these anti-epilepsy medications.

Setting: The researchers reviewed literature related to the general side effects, psychological, social and economic challenges associated with anti- epilepsy medication. Read More

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http://dx.doi.org/10.4102/phcfm.v12i1.2162DOI Listing

Cantú syndrome versus Zimmermann-Laband syndrome: Report of nine individuals with ABCC9 variants.

Eur J Med Genet 2020 Jul 2:103996. Epub 2020 Jul 2.

Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address:

Cantú syndrome (CS) is a rare developmental disorder characterized by a coarse facial appearance, macrocephaly, hypertrichosis, skeletal and cardiovascular anomalies and caused by heterozygous gain-of-function variants in ABCC9 and KCNJ8, encoding heterooctameric ATP-sensitive potassium (K) channels. CS shows considerable clinical overlap with Zimmermann-Laband syndrome (ZLS), a rare condition with coarse facial features, hypertrichosis, gingival overgrowth, intellectual disability of variable degree, and hypoplasia or aplasia of terminal phalanges and/or nails. ZLS is caused by heterozygous gain-of-function variants in KCNH1 or KCNN3, and gain-of-function KCNK4 variants underlie the clinically similar FHEIG (facial dysmorphism, hypertrichosis, epilepsy, intellectual disability/developmental delay, and gingival overgrowth) syndrome; KCNH1, KCNN3 and KCNK4 encode potassium channels. Read More

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http://dx.doi.org/10.1016/j.ejmg.2020.103996DOI Listing

Precision Calcium Imaging of Dense Neural Populations via a Cell-Body-Targeted Calcium Indicator.

Neuron 2020 Jun 26. Epub 2020 Jun 26.

The MIT Media Laboratory, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA; Department of Biological Engineering, MIT, Cambridge, MA, USA; MIT Center for Neurobiological Engineering, MIT, Cambridge, MA, USA; Department of Brain and Cognitive Sciences, MIT, Cambridge, MA, USA; MIT McGovern Institute for Brain Research, MIT, Cambridge, MA, USA; Koch Institute, MIT, Cambridge, MA 02139, USA. Electronic address:

Methods for one-photon fluorescent imaging of calcium dynamics can capture the activity of hundreds of neurons across large fields of view at a low equipment complexity and cost. In contrast to two-photon methods, however, one-photon methods suffer from higher levels of crosstalk from neuropil, resulting in a decreased signal-to-noise ratio and artifactual correlations of neural activity. We address this problem by engineering cell-body-targeted variants of the fluorescent calcium indicators GCaMP6f and GCaMP7f. Read More

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http://dx.doi.org/10.1016/j.neuron.2020.05.029DOI Listing

Epilepsy in paediatric patients with schizencephaly.

Ann Agric Environ Med 2020 Jun 2;27(2):279-283. Epub 2020 Jun 2.

Department of Basic Biomedical Science, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland.

Introduction: Schizencephaly is one of the rare congenital defects of the central nervous system (CNS), known as neuronal migration disorders. The etiology of schizencecephaly is unequivocal. Established etiologies include in-utero infections (cytomegalovirus and herpes simplex virus, HSV type I), toxic abuse (cocaine, alcohol), as well as drug use (warfarin). Read More

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http://dx.doi.org/10.26444/aaem/122796DOI Listing

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction.

Nat Commun 2020 Jun 19;11(1):3150. Epub 2020 Jun 19.

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.

MLKL is the essential effector of necroptosis, a form of programmed lytic cell death. We have isolated a mouse strain with a single missense mutation, Mlkl, that alters the two-helix 'brace' that connects the killer four-helix bundle and regulatory pseudokinase domains. This confers constitutive, RIPK3 independent killing activity to MLKL. Read More

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http://dx.doi.org/10.1038/s41467-020-16819-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305203PMC
June 2020
10.742 Impact Factor

-associated neurodevelopmental disorder.

J Med Genet 2020 Jun 16. Epub 2020 Jun 16.

Department of Medical Genetics, The University of British Columbia, Vancouver, British Columbia, Canada.

Background: Dysfunction of histone methyltransferases and chromatin modifiers has been implicated in complex neurodevelopmental syndromes and cancers. encodes a lysine-specific methyltransferase that assists in transcriptional activation of genes by depositing H3K4 methyl marks. Previous reports of patients with rare variants in describe a distinctive phenotype that includes seizures, global developmental delay and intellectual disability. Read More

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http://dx.doi.org/10.1136/jmedgenet-2019-106756DOI Listing

Depression in children with epilepsy from western China: A cross-sectional survey.

Medicine (Baltimore) 2020 Jun;99(24):e20647

Department of Pharmacy, Evidence-Based Pharmacy Center, West China Second Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education.

This study investigated the prevalence of depression among children with epilepsy and evaluated factors associated with depression.Participants who met the selection criteria were included in this cross-sectional study, which was conducted at the Pediatric Neurology Department of the West China Women's and Children's Hospital from January to May 2018. Depression status among children with epilepsy was evaluated by the Depression Self-Rating Scale for Children (DSRSC). Read More

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http://dx.doi.org/10.1097/MD.0000000000020647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302592PMC

A recurrent PJA1 variant in trigonocephaly and neurodevelopmental disorders.

Ann Clin Transl Neurol 2020 Jun 12. Epub 2020 Jun 12.

Department of Neurodevelopmental Disorder Genetics, Institute of Brain Science, Nagoya City University Graduate School of Medical Science, Nagoya, Aichi, 467-8601, Japan.

Objective: Neurodevelopmental disorders (NDDs) often associate with epilepsy or craniofacial malformations. Recent large-scale DNA analyses identified hundreds of candidate genes for NDDs, but a large portion of the cases still remain unexplained. We aimed to identify novel candidate genes for NDDs. Read More

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http://dx.doi.org/10.1002/acn3.51093DOI Listing

Congenital subpendymal giant cell astrocytoma in children with tuberous sclerosis complex: growth patterns and neurological outcome.

Pediatr Res 2020 Jun 9. Epub 2020 Jun 9.

Sydney Children's Hospital, Sydney, NSW, Australia.

Background: Literature regarding congenital subependymal giant cell astrocytomas (SEGA) is limited, and suggests they are at risk of rapid growth and complications. We sought to characterise the growth patterns of congenital SEGA. The second part of the study was an exploratory analysis of congenital SEGA as a possible biomarker for poor neurological outcome. Read More

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http://dx.doi.org/10.1038/s41390-020-1002-7DOI Listing

Light-emitting-diode and Grass PS 33 xenon lamp photic stimulators are equivalent in the assessment of photosensitivity: Clinical and research implications.

Epilepsy Res 2020 Jun 1;165:106377. Epub 2020 Jun 1.

Department of Clinical Neurophysiology, Birmingham Women's and Children's Hospital NHS Foundation Trust, Birmingham, UK; School of Life and Health Sciences, Aston Neuroscience Institute, Aston University, Birmingham, UK. Electronic address:

The assessment of the effect of photic stimulation is an integral component of an EEG exam and is especially important in patients referred for ascertained or suspected photosensitivity with or without a diagnosis of epilepsy. A positive test result relies on eliciting a specific abnormality defined as the "photoparoxysmal response". Reliability of this assessment is strongly influenced by technical and procedural variables, a critical one represented by the physical properties of the stimulators used. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2020.106377DOI Listing

Great expectations: virus-mediated gene therapy in neurological disorders.

J Neurol Neurosurg Psychiatry 2020 Jun 5. Epub 2020 Jun 5.

Neurology, Sydney Children's Hospital Randwick, Randwick, New South Wales, Australia

Gene therapy (GT) has tremendous potential for the treatment of neurological disorders to transform patient care. The successful application of virus-mediated GT to treat spinal muscular atrophy is a significant milestone, serving to accelerate similar progress in a spectrum of neurological conditions, with more than 50 clinical trials currently underway, across neurodevelopmental, neurodegenerative, muscular dystrophy, epilepsy, chronic pain and neoplastic diseases. This review provides an overview of the key features of virus-mediated GT, paradigms of delivery and dosing, potential risks and highlights ongoing research to optimise safe and effective delivery of vectors into the nervous system. Read More

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http://dx.doi.org/10.1136/jnnp-2019-322327DOI Listing

Variability in the analysis of a single neuroimaging dataset by many teams.

Authors:
Rotem Botvinik-Nezer Felix Holzmeister Colin F Camerer Anna Dreber Juergen Huber Magnus Johannesson Michael Kirchler Roni Iwanir Jeanette A Mumford R Alison Adcock Paolo Avesani Blazej M Baczkowski Aahana Bajracharya Leah Bakst Sheryl Ball Marco Barilari Nadège Bault Derek Beaton Julia Beitner Roland G Benoit Ruud M W J Berkers Jamil P Bhanji Bharat B Biswal Sebastian Bobadilla-Suarez Tiago Bortolini Katherine L Bottenhorn Alexander Bowring Senne Braem Hayley R Brooks Emily G Brudner Cristian B Calderon Julia A Camilleri Jaime J Castrellon Luca Cecchetti Edna C Cieslik Zachary J Cole Olivier Collignon Robert W Cox William A Cunningham Stefan Czoschke Kamalaker Dadi Charles P Davis Alberto De Luca Mauricio R Delgado Lysia Demetriou Jeffrey B Dennison Xin Di Erin W Dickie Ekaterina Dobryakova Claire L Donnat Juergen Dukart Niall W Duncan Joke Durnez Amr Eed Simon B Eickhoff Andrew Erhart Laura Fontanesi G Matthew Fricke Shiguang Fu Adriana Galván Remi Gau Sarah Genon Tristan Glatard Enrico Glerean Jelle J Goeman Sergej A E Golowin Carlos González-García Krzysztof J Gorgolewski Cheryl L Grady Mikella A Green João F Guassi Moreira Olivia Guest Shabnam Hakimi J Paul Hamilton Roeland Hancock Giacomo Handjaras Bronson B Harry Colin Hawco Peer Herholz Gabrielle Herman Stephan Heunis Felix Hoffstaedter Jeremy Hogeveen Susan Holmes Chuan-Peng Hu Scott A Huettel Matthew E Hughes Vittorio Iacovella Alexandru D Iordan Peder M Isager Ayse I Isik Andrew Jahn Matthew R Johnson Tom Johnstone Michael J E Joseph Anthony C Juliano Joseph W Kable Michalis Kassinopoulos Cemal Koba Xiang-Zhen Kong Timothy R Koscik Nuri Erkut Kucukboyaci Brice A Kuhl Sebastian Kupek Angela R Laird Claus Lamm Robert Langner Nina Lauharatanahirun Hongmi Lee Sangil Lee Alexander Leemans Andrea Leo Elise Lesage Flora Li Monica Y C Li Phui Cheng Lim Evan N Lintz Schuyler W Liphardt Annabel B Losecaat Vermeer Bradley C Love Michael L Mack Norberto Malpica Theo Marins Camille Maumet Kelsey McDonald Joseph T McGuire Helena Melero Adriana S Méndez Leal Benjamin Meyer Kristin N Meyer Glad Mihai Georgios D Mitsis Jorge Moll Dylan M Nielson Gustav Nilsonne Michael P Notter Emanuele Olivetti Adrian I Onicas Paolo Papale Kaustubh R Patil Jonathan E Peelle Alexandre Pérez Doris Pischedda Jean-Baptiste Poline Yanina Prystauka Shruti Ray Patricia A Reuter-Lorenz Richard C Reynolds Emiliano Ricciardi Jenny R Rieck Anais M Rodriguez-Thompson Anthony Romyn Taylor Salo Gregory R Samanez-Larkin Emilio Sanz-Morales Margaret L Schlichting Douglas H Schultz Qiang Shen Margaret A Sheridan Jennifer A Silvers Kenny Skagerlund Alec Smith David V Smith Peter Sokol-Hessner Simon R Steinkamp Sarah M Tashjian Bertrand Thirion John N Thorp Gustav Tinghög Loreen Tisdall Steven H Tompson Claudio Toro-Serey Juan Jesus Torre Tresols Leonardo Tozzi Vuong Truong Luca Turella Anna E van 't Veer Tom Verguts Jean M Vettel Sagana Vijayarajah Khoi Vo Matthew B Wall Wouter D Weeda Susanne Weis David J White David Wisniewski Alba Xifra-Porxas Emily A Yearling Sangsuk Yoon Rui Yuan Kenneth S L Yuen Lei Zhang Xu Zhang Joshua E Zosky Thomas E Nichols Russell A Poldrack Tom Schonberg

Nature 2020 06 20;582(7810):84-88. Epub 2020 May 20.

Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.

Data analysis workflows in many scientific domains have become increasingly complex and flexible. Here we assess the effect of this flexibility on the results of functional magnetic resonance imaging by asking 70 independent teams to analyse the same dataset, testing the same 9 ex-ante hypotheses. The flexibility of analytical approaches is exemplified by the fact that no two teams chose identical workflows to analyse the data. Read More

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http://dx.doi.org/10.1038/s41586-020-2314-9DOI Listing
June 2020
42.351 Impact Factor

TSC2 pathogenic variants are predictive of severe clinical manifestations in TSC infants: results of the EPISTOP study.

Genet Med 2020 May 28. Epub 2020 May 28.

Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Purpose: To perform comprehensive genotyping of TSC1 and TSC2 in a cohort of 94 infants with tuberous sclerosis complex (TSC) and correlate with clinical manifestations.

Methods: Infants were enrolled at age <4 months, and subject to intensive clinical monitoring including electroencephalography (EEG), brain magnetic resonance imaging (MRI), and neuropsychological assessment. Targeted massively parallel sequencing (MPS), genome sequencing, and multiplex ligation-dependent probe amplification (MLPA) were used for variant detection in TSC1/TSC2. Read More

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http://dx.doi.org/10.1038/s41436-020-0823-4DOI Listing

The self-stigma of patients with epilepsy in Japan: A qualitative approach.

Epilepsy Behav 2020 Aug 21;109:106994. Epub 2020 May 21.

Department of Psychiatry, Saitama Medical Center, Saitama Medical University, Saitama, Japan.

The mental health of patients with epilepsy represents a substantial public health concern in Japan. For instance, the Japanese term for epilepsy, "tenkan", has the negative meaning of "mad" and "a violent temperament that is apt to be infatuated". Although epilepsy is now understood as a disease caused by abnormal neuronal activity in the brain, discrimination and stigma against people with epilepsy remain deeply rooted in Japanese culture. Read More

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http://dx.doi.org/10.1016/j.yebeh.2020.106994DOI Listing

Abolishing spontaneous epileptiform activity in human brain tissue through AMPA receptor inhibition.

Ann Clin Transl Neurol 2020 06 19;7(6):883-890. Epub 2020 May 19.

Aston Neuroscience Institute, School of Life and Health Sciences, Aston University, Birmingham, UK.

Objective: The amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) is increasingly recognized as a therapeutic target in drug-refractory pediatric epilepsy. Perampanel (PER) is a non-competitive AMPAR antagonist, and pre-clinical studies have shown the AMPAR-mediated anticonvulsant effects of decanoic acid (DEC), a major medium-chain fatty acid provided in the medium-chain triglyceride ketogenic diet.

Methods: Using brain tissue resected from children with intractable epilepsy, we recorded the effects of PER and DEC in vitro. Read More

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http://dx.doi.org/10.1002/acn3.51030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318092PMC

Mapping language networks and their association with verbal abilities in paediatric epilepsy using MEG and graph analysis.

Neuroimage Clin 2020 Apr 29;27:102265. Epub 2020 Apr 29.

School of Life and Health Sciences, Aston Brain Centre, Aston University, Birmingham, UK; Children's Epilepsy Surgery Service, Birmingham Women's and Children's Hospital, Birmingham, UK.

Recent theoretical models of language have emphasised the importance of integration within distributed networks during language processing. This is particularly relevant to young patients with epilepsy, as the topology of the functional network and its dynamics may be altered by the disease, resulting in reorganisation of functional language networks. Thus, understanding connectivity within the language network in patients with epilepsy could provide valuable insights into healthy and pathological brain function, particularly when combined with clinical correlates. Read More

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http://dx.doi.org/10.1016/j.nicl.2020.102265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226893PMC

Prognostic factors among children with acute encephalitis/encephalopathy associated with viral and other pathogens.

Clin Infect Dis 2020 May 7. Epub 2020 May 7.

Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan.

Background: Acute encephalitis/encephalopathy (AE) associated with viral and other pathogens leads to neurological sequelae and mortality. Knowing the prognostic factors is therefore important for immediate interventions. We examined early-phase unfavorable prognostic factors among children with AE using a nationwide database. Read More

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http://dx.doi.org/10.1093/cid/ciaa536DOI Listing

Phenotypic spectrum and transcriptomic profile associated with germline variants in TRAF7.

Authors:
Laura Castilla-Vallmanya Kaja K Selmer Clémantine Dimartino Raquel Rabionet Bernardo Blanco-Sánchez Sandra Yang Margot R F Reijnders Antonie J van Essen Myriam Oufadem Magnus D Vigeland Barbro Stadheim Gunnar Houge Helen Cox Helen Kingston Jill Clayton-Smith Jeffrey W Innis Maria Iascone Anna Cereda Sara Gabbiadini Wendy K Chung Victoria Sanders Joel Charrow Emily Bryant John Millichap Antonio Vitobello Christel Thauvin Frederic Tran Mau-Them Laurence Faivre Gaetan Lesca Audrey Labalme Christelle Rougeot Nicolas Chatron Damien Sanlaville Katherine M Christensen Amelia Kirby Raymond Lewandowski Rachel Gannaway Maha Aly Anna Lehman Lorne Clarke Luitgard Graul-Neumann Christiane Zweier Davor Lessel Bernarda Lozic Ingvild Aukrust Ryan Peretz Robert Stratton Thomas Smol Anne Dieux-Coëslier Joanna Meira Elizabeth Wohler Nara Sobreira Erin M Beaver Jennifer Heeley Lauren C Briere Frances A High David A Sweetser Melissa A Walker Catherine E Keegan Parul Jayakar Marwan Shinawi Wilhelmina S Kerstjens-Frederikse Dawn L Earl Victoria M Siu Emma Reesor Tony Yao Robert A Hegele Olena M Vaske Shannon Rego Kevin A Shapiro Brian Wong Michael J Gambello Marie McDonald Danielle Karlowicz Roberto Colombo Alessandro Serretti Lynn Pais Anne O'Donnell-Luria Alison Wray Simon Sadedin Belinda Chong Tiong Y Tan John Christodoulou Susan M White Anne Slavotinek Deborah Barbouth Dayna Morel Swols Mélanie Parisot Christine Bole-Feysot Patrick Nitschké Véronique Pingault Arnold Munnich Megan T Cho Valérie Cormier-Daire Susanna Balcells Stanislas Lyonnet Daniel Grinberg Jeanne Amiel Roser Urreizti Christopher T Gordon

Genet Med 2020 Jul 7;22(7):1215-1226. Epub 2020 May 7.

Laboratory of embryology and genetics of human malformations, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR 1163, Institut Imagine, Paris, France.

Purpose: Somatic variants in tumor necrosis factor receptor-associated factor 7 (TRAF7) cause meningioma, while germline variants have recently been identified in seven patients with developmental delay and cardiac, facial, and digital anomalies. We aimed to define the clinical and mutational spectrum associated with TRAF7 germline variants in a large series of patients, and to determine the molecular effects of the variants through transcriptomic analysis of patient fibroblasts.

Methods: We performed exome, targeted capture, and Sanger sequencing of patients with undiagnosed developmental disorders, in multiple independent diagnostic or research centers. Read More

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http://dx.doi.org/10.1038/s41436-020-0792-7DOI Listing
July 2020
7.329 Impact Factor

Tablet-based electroencephalography diagnostics for patients with epilepsy in the West African Republic of Guinea.

Eur J Neurol 2020 May 2. Epub 2020 May 2.

Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.

Background And Purpose: Epilepsy is most common in lower-income settings where access to electroencephalography (EEG) is generally poor. A low-cost tablet-based EEG device may be valuable, but the quality and reproducibility of the EEG output are not established.

Methods: Tablet-based EEG was deployed in a heterogeneous epilepsy cohort in the Republic of Guinea (2018-2019), consisting of a tablet wirelessly connected to a 14-electrode cap. Read More

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http://dx.doi.org/10.1111/ene.14291DOI Listing
May 2020
4.055 Impact Factor

Seizures during treatment of childhood acute lymphoblastic leukemia: A population-based cohort study.

Eur J Paediatr Neurol 2020 Apr 18. Epub 2020 Apr 18.

University of Uppsala, Department of Women's and Children's Health, Uppsala, Sweden.

Background: Seizures are common in children with acute lymphoblastic leukemia (ALL). As ALL survival rates are improving, the challenge to minimize treatment related side effects and late sequelae rises. Here, we studied the frequency, timing, etiology and risk factors of seizures in ALL patients. Read More

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http://dx.doi.org/10.1016/j.ejpn.2020.04.004DOI Listing

Neuronal ceroid lipofuscinosis type 2: an Australian case series.

J Paediatr Child Health 2020 Apr 24. Epub 2020 Apr 24.

Genetic Metabolic Disorders Service, The Sydney Children's Hospitals Network, Sydney, New South Wales, Australia.

Aim: Late infantile neuronal ceroid lipofuscinosis type 2 (CLN2) disease is a rare neurodegenerative disorder presenting in children aged 2-4 years with seizures and loss of motor and language skills, followed by blindness and death in late childhood. Initial presenting features are similar to a range of common epilepsies. We aim to highlight typical clinical and radiological features that may prompt diagnosis of CLN2 disease in early disease stages. Read More

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http://dx.doi.org/10.1111/jpc.14890DOI Listing

Keeping people with epilepsy safe during the COVID-19 pandemic.

Neurology 2020 06 23;94(23):1032-1037. Epub 2020 Apr 23.

From the Department Neurology (J.A.F.), NYU Grossman School of Medicine New York University, NY; Epilepsy Unit (M.J.B.), International Bureau for Epilepsy, Scottish Epilepsy Initiative, Glasgow, Scotland; Neurology (R.C.), Hospital J P Garrahan, Buenos Aires, AR; Department Neurology (O.D.), NYU Grossman School of Medicine, NY; Institute of Neurology (D.D.), Huashan Hospital, Fudan University, Shanghai, China; Cleveland Clinic Epilepsy Center (L.J.), Cleveland, OH; Department of Neurology (N.J.), Icahn School of Medicine at Mount Sinai, New York, NY; Division of Epilepsy (A.K.), Department of Neurology, Miller School of Medicine, University of Miami, FL; Cincinnati Children's Hospital Medical Center (A.C.M.), School of Medicine, University of Cincinnati, OH; KEMRI-Wellcome Programme (C.R.N.), Kilifi, Kenya and Department of Psychiatry (C.R.N.), University of Oxford, United Kingdom; Division of Epilepsy and Clinical Neurophysiology (A.A.P.), Department of Neurology, Harvard Medical School, Boston Children's Hospital, MA; Harvard Medical School (P.B.P.), Brigham and Women's Hospital, Boston, MA; Department of Internal Medicine and Therapeutics (E.P.), University of Pavia and IRCCS Mondino Foundation, Member of the ERN EpiCARE, Pavia, Italy; UCL Queen Square Institute of Neurology (J.W.S.), London, United Kingdom and Stichting Epilepsie Instelligen Nederland (SEIN) (J.W.S.), Heemstede, Netherlands; University of Melbourne (I.E.S.), Austin and Royal Children's Hospitals, Florey and Murdoch Children's Research Institutes, Melbourne, Australia; Dayanand Medical College (G.S.), Ludhiana, India; Matthew's Friends-Ketogenic Dietary Therapies (E.W.), London, United Kingdom; Department of Paediatric Neurology (J.W.), Red Cross War Memorial Children's Hospital, Neuroscience Institute, Cape Town, South Africa; and UCL NIHR BRC Great Ormond Street Institute of Child Health (J.H.C.), Great Ormond Street Hospital for Children, London, United Kingdom and Member of the ERN EpiCARE (J.H.C.), Young Epilepsy, Lingfield, United Kingdom.

Objectives: To provide information on the effect of the coronavirus disease of 2019 (COVID-19) pandemic on people with epilepsy and provide consensus recommendations on how to provide the best possible care for people with epilepsy while avoiding visits to urgent care facilities and hospitalizations during the novel coronavirus pandemic.

Methods: The authors developed consensus statements in 2 sections. The first was "How should we/clinicians modify our clinical care pathway for people with epilepsy during the COVID-19 pandemic?" The second was "What general advice should we give to people with epilepsy during this crisis? The authors individually scored statements on a scale of -10 (strongly disagree) to +10 (strongly agree). Read More

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http://dx.doi.org/10.1212/WNL.0000000000009632DOI Listing
June 2020
8.286 Impact Factor

Intraocular cataract lens replacement and light exposure potentially impact procedural learning in older adults.

J Sleep Res 2020 Apr 14:e13043. Epub 2020 Apr 14.

Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel, Basel, Switzerland.

Procedural learning declines with age and appropriately timed light exposure can improve cognitive performance in older individuals. Because cataract reduces light transmission and is associated with cognitive decline in older adults, we explored whether lens replacement (intraocular blue-blocking [BB] or UV-only blocking) in older patients with cataracts enhances the beneficial effects of light on procedural learning. Healthy older participants (n = 16) and older patients with post-cataract surgery (n = 13 with BB or UV lens replacement) underwent a randomized within-subject crossover laboratory design with three protocols. Read More

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http://dx.doi.org/10.1111/jsr.13043DOI Listing

A Novel Integrative Psychotherapy for Psychogenic Nonepileptic Seizures Based on the Biopsychosocial Model: A Retrospective Pilot Outcome Study.

Psychosomatics 2020 Jul - Aug;61(4):353-362. Epub 2020 Feb 24.

Neuropsychiatry Clinic, Hadassah Hebrew University Medical Center, Jerusalem, Israel; Department of Medical Neurobiology, Faculty of Medicine, Hebrew University of Jerusalem, Israel; Jerusalem Mental Health Center, Hebrew University Medical School, Jerusalem, Israel; Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Background: Psychogenic nonepileptic seizures (PNES) represent one of the most sizable treatment challenges in neuropsychiatry. Although the underlying mechanism is far from being understood, several interventions have been suggested. However, patients with comorbid psychiatric diagnoses and epilepsy are excluded from most intervention studies. Read More

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http://dx.doi.org/10.1016/j.psym.2020.02.006DOI Listing
February 2020

Reply to Dr. Capovilla on "Reply to the article "Management of status epilepticus in adults. Position paper of the Italian League Against Epilepsy".

Epilepsy Behav 2020 Jun 6;107:107048. Epub 2020 Apr 6.

IRCCS Istituto delle Scienze Neurologiche, Bellaria Hospital, Bologna, Italy; Department of Biomedical and Neuromotor Sciences, University of Bologna, Italy.

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http://dx.doi.org/10.1016/j.yebeh.2020.107048DOI Listing

A Novel WAC Loss of Function Mutation in an Individual Presenting with Encephalopathy Related to Status Epilepticus during Sleep (ESES).

Genes (Basel) 2020 03 24;11(3). Epub 2020 Mar 24.

Molecular Genetics of Neurodevelopment, Department of Women's and Children's Health, University of Padova, 35128 Padova, Italy.

WAC (WW Domain Containing Adaptor With Coiled-Coil) mutations have been reported in only 20 individuals presenting a neurodevelopmental disorder characterized by intellectual disability, neonatal hypotonia, behavioral problems, and mildly dysmorphic features. Using targeted deep sequencing, we screened a cohort of 630 individuals with variable degrees of intellectual disability and identified five rare variants: two variants were inherited from healthy parents; two previously reported de novo mutations, c.1661_1664del (p. Read More

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http://dx.doi.org/10.3390/genes11030344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141116PMC

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries.

Authors:
Paul M Thompson Neda Jahanshad Christopher R K Ching Lauren E Salminen Sophia I Thomopoulos Joanna Bright Bernhard T Baune Sara Bertolín Janita Bralten Willem B Bruin Robin Bülow Jian Chen Yann Chye Udo Dannlowski Carolien G F de Kovel Gary Donohoe Lisa T Eyler Stephen V Faraone Pauline Favre Courtney A Filippi Thomas Frodl Daniel Garijo Yolanda Gil Hans J Grabe Katrina L Grasby Tomas Hajek Laura K M Han Sean N Hatton Kevin Hilbert Tiffany C Ho Laurena Holleran Georg Homuth Norbert Hosten Josselin Houenou Iliyan Ivanov Tianye Jia Sinead Kelly Marieke Klein Jun Soo Kwon Max A Laansma Jeanne Leerssen Ulrike Lueken Abraham Nunes Joseph O' Neill Nils Opel Fabrizio Piras Federica Piras Merel C Postema Elena Pozzi Natalia Shatokhina Carles Soriano-Mas Gianfranco Spalletta Daqiang Sun Alexander Teumer Amanda K Tilot Leonardo Tozzi Celia van der Merwe Eus J W Van Someren Guido A van Wingen Henry Völzke Esther Walton Lei Wang Anderson M Winkler Katharina Wittfeld Margaret J Wright Je-Yeon Yun Guohao Zhang Yanli Zhang-James Bhim M Adhikari Ingrid Agartz Moji Aghajani André Aleman Robert R Althoff Andre Altmann Ole A Andreassen David A Baron Brenda L Bartnik-Olson Janna Marie Bas-Hoogendam Arielle R Baskin-Sommers Carrie E Bearden Laura A Berner Premika S W Boedhoe Rachel M Brouwer Jan K Buitelaar Karen Caeyenberghs Charlotte A M Cecil Ronald A Cohen James H Cole Patricia J Conrod Stephane A De Brito Sonja M C de Zwarte Emily L Dennis Sylvane Desrivieres Danai Dima Stefan Ehrlich Carrie Esopenko Graeme Fairchild Simon E Fisher Jean-Paul Fouche Clyde Francks Sophia Frangou Barbara Franke Hugh P Garavan David C Glahn Nynke A Groenewold Tiril P Gurholt Boris A Gutman Tim Hahn Ian H Harding Dennis Hernaus Derrek P Hibar Frank G Hillary Martine Hoogman Hilleke E Hulshoff Pol Maria Jalbrzikowski George A Karkashadze Eduard T Klapwijk Rebecca C Knickmeyer Peter Kochunov Inga K Koerte Xiang-Zhen Kong Sook-Lei Liew Alexander P Lin Mark W Logue Eileen Luders Fabio Macciardi Scott Mackey Andrew R Mayer Carrie R McDonald Agnes B McMahon Sarah E Medland Gemma Modinos Rajendra A Morey Sven C Mueller Pratik Mukherjee Leyla Namazova-Baranova Talia M Nir Alexander Olsen Peristera Paschou Daniel S Pine Fabrizio Pizzagalli Miguel E Rentería Jonathan D Rohrer Philipp G Sämann Lianne Schmaal Gunter Schumann Mark S Shiroishi Sanjay M Sisodiya Dirk J A Smit Ida E Sønderby Dan J Stein Jason L Stein Masoud Tahmasian David F Tate Jessica A Turner Odile A van den Heuvel Nic J A van der Wee Ysbrand D van der Werf Theo G M van Erp Neeltje E M van Haren Daan van Rooij Laura S van Velzen Ilya M Veer Dick J Veltman Julio E Villalon-Reina Henrik Walter Christopher D Whelan Elisabeth A Wilde Mojtaba Zarei Vladimir Zelman

Transl Psychiatry 2020 Mar 20;10(1):100. Epub 2020 Mar 20.

Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development and aging; still other WGs develop methodological pipelines and tools to facilitate harmonized analyses of "big data" (i. Read More

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http://dx.doi.org/10.1038/s41398-020-0705-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083923PMC
March 2020
4.360 Impact Factor

Serum Neurosteroid Levels Are Associated With Cortical Thickness in Individuals Diagnosed With Posttraumatic Stress Disorder and History of Mild Traumatic Brain Injury.

Clin EEG Neurosci 2020 Jul 18;51(4):285-299. Epub 2020 Mar 18.

Department of Psychiatry, Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Posttraumatic stress disorder (PTSD) co-occurring with mild traumatic brain injury (mTBI) is common in veterans. Worse clinical outcome in those with PTSD has been associated with decreased serum neurosteroid levels. Furthermore, decreased cortical thickness has been associated with both PTSD and mTBI. Read More

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http://dx.doi.org/10.1177/1550059420909676DOI Listing

De Novo Truncating Variants in the Last Exon of SEMA6B Cause Progressive Myoclonic Epilepsy.

Am J Hum Genet 2020 04 12;106(4):549-558. Epub 2020 Mar 12.

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan. Electronic address:

De novo variants (DNVs) cause many genetic diseases. When DNVs are examined in the whole coding regions of genes in next-generation sequencing analyses, pathogenic DNVs often cluster in a specific region. One such region is the last exon and the last 50 bp of the penultimate exon, where truncating DNVs cause escape from nonsense-mediated mRNA decay [NMD(-) region]. Read More

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http://dx.doi.org/10.1016/j.ajhg.2020.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118575PMC

Central neurogenetic signatures of the visuomotor integration system.

Proc Natl Acad Sci U S A 2020 03 6;117(12):6836-6843. Epub 2020 Mar 6.

Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115;

Visuomotor impairments characterize numerous neurological disorders and neurogenetic syndromes, such as autism spectrum disorder (ASD) and Dravet, Fragile X, Prader-Willi, Turner, and Williams syndromes. Despite recent advances in systems neuroscience, the biological basis underlying visuomotor functional impairments associated with these clinical conditions is poorly understood. In this study, we used neuroimaging connectomic approaches to map the visuomotor integration (VMI) system in the human brain and investigated the topology approximation of the VMI network to the Allen Human Brain Atlas, a whole-brain transcriptome-wide atlas of cortical genetic expression. Read More

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http://dx.doi.org/10.1073/pnas.1912429117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104395PMC
March 2020
9.809 Impact Factor

Seizures and quinolone antibiotics in children: a systematic review of adverse events.

Eur J Hosp Pharm 2020 Mar 28;27(2):60-64. Epub 2019 Jan 28.

Department of Women's and Children's Health, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

Background: Quinolone antibiotics have a broad spectrum of activity including against Gram-negative organisms (especially ), but their use has been associated with the development of seizures. Our objective was to evaluate the association between the administration of quinolones and seizures for three groups of children: those with epilepsy; those with other CNS disorders; and those without any CNS disorder.

Method: We conducted a systematic review of the MEDLINE, EMBASE and CENTRAL databases. Read More

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http://dx.doi.org/10.1136/ejhpharm-2018-001805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043247PMC

Outcome measurement in functional neurological disorder: a systematic review and recommendations.

J Neurol Neurosurg Psychiatry 2020 Jun 28;91(6):638-649. Epub 2020 Feb 28.

Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK

Objectives: We aimed to identify existing outcome measures for functional neurological disorder (FND), to inform the development of recommendations and to guide future research on FND outcomes.

Methods: A systematic review was conducted to identify existing FND-specific outcome measures and the most common measurement domains and measures in previous treatment studies. Searches of Embase, MEDLINE and PsycINFO were conducted between January 1965 and June 2019. Read More

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http://dx.doi.org/10.1136/jnnp-2019-322180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279198PMC
June 2020
6.807 Impact Factor

Clinical and biochemical improvement with galactose supplementation in SLC35A2-CDG.

Genet Med 2020 Jun 27;22(6):1102-1107. Epub 2020 Feb 27.

Department of Paediatrics and Metabolic Center, University Hospitals Leuven, Leuven, Belgium.

Purpose: We studied galactose supplementation in SLC35A2-congenital disorder of glycosylation (SLC35A2-CDG), caused by monoallelic pathogenic variants in SLC35A2 (Xp11.23), encoding the endoplasmic reticulum (ER) and Golgi UDP-galactose transporter. Patients present with epileptic encephalopathy, developmental disability, growth deficiency, and dysmorphism. Read More

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http://dx.doi.org/10.1038/s41436-020-0767-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275909PMC

Consensus-based statements for the management of mitochondrial stroke-like episodes.

Wellcome Open Res 2019 13;4:201. Epub 2019 Dec 13.

Wellcome Centre for Mitochondrial Research, Newcastle University, UK, Newcastle upon Tyne, Tyne and Wear, NE2 4HH, UK.

Focal-onset seizures and encephalopathy are prominent features of a stroke-like episode, which is a severe neurological manifestation associated with subtypes of mitochondrial disease. Despite more than 30 years of research, the acute treatment of stroke-like episodes remains controversial. We used the modified Delphi process to harness the clinical expertise of a group of mitochondrial disease specialists from five European countries to produce consensus guidance for the acute management of stroke-like episodes and commonly associated complications. Read More

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http://dx.doi.org/10.12688/wellcomeopenres.15599.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014928PMC
December 2019

Very late-onset mitochondrial cytopathy featuring epilepsia partialis continua and bilateral deafness: A case report.

Seizure 2020 Jan 28;76:153-155. Epub 2020 Jan 28.

Oxford Epilepsy Research Group, NIHR Biomedical Research Centre, Nuffield Department of Clinical Neuroscience, John Radcliffe Hospital, Oxford OX3 9DU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.seizure.2020.01.020DOI Listing
January 2020

Outcomes of a primary care mental health implementation program in rural Rwanda: A quasi-experimental implementation-effectiveness study.

PLoS One 2020 21;15(2):e0228854. Epub 2020 Feb 21.

Partners In Health, Boston, MA, United States of America.

Introduction: To address the know-do gap in the integration of mental health care into primary care in resource-limited settings, a multi-faceted implementation program initially designed to integrate HIV/AIDS care into primary care was adapted for severe mental disorders and epilepsy in Burera District, Rwanda. The Mentoring and Enhanced Supervision at Health Centers (MESH MH) program supported primary care-delivered mental health service delivery scale-up from 6 to 19 government-run health centers over two years. This quasi-experimental study assessed implementation reach, fidelity, and clinical outcomes at health centers supported by MESH MH during the scale up period. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0228854PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035003PMC
May 2020
3.234 Impact Factor

Sexual and reproductive healthcare for adolescent and young adult women with epilepsy: A qualitative study of pediatric neurologists and epileptologists.

Epilepsy Behav 2020 Mar 24;104(Pt A):106911. Epub 2020 Jan 24.

Division of Adolescent and Young Adult Medicine, UPMC Children's Hospital of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA 15224, United States of America; Center for Women's Health Research and Innovation, 230 McKee Place, Pittsburgh, PA 15213, United States of America. Electronic address:

Objective: The objective of this study was to explore the attitudes and practices of pediatric neurologists and epileptologists regarding sexual and reproductive healthcare for adolescent and young adult women with epilepsy (WWE).

Background: Adolescent and young adult WWE have unique sexual and reproductive healthcare needs, including counseling on teratogenesis, folic acid, and interactions between contraception and antiseizure medications. There are no prior studies regarding sexual and reproductive healthcare practices of pediatric neurologists or epileptologists. Read More

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http://dx.doi.org/10.1016/j.yebeh.2020.106911DOI Listing

GATAD2B-associated neurodevelopmental disorder (GAND): clinical and molecular insights into a NuRD-related disorder.

Genet Med 2020 May 17;22(5):878-888. Epub 2020 Jan 17.

Department of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Purpose: Determination of genotypic/phenotypic features of GATAD2B-associated neurodevelopmental disorder (GAND).

Methods: Fifty GAND subjects were evaluated to determine consistent genotypic/phenotypic features. Immunoprecipitation assays utilizing in vitro transcription-translation products were used to evaluate GATAD2B missense variants' ability to interact with binding partners within the nucleosome remodeling and deacetylase (NuRD) complex. Read More

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http://dx.doi.org/10.1038/s41436-019-0747-zDOI Listing

Expanding the genotype-phenotype correlation of de novo heterozygous missense variants in YWHAG as a cause of developmental and epileptic encephalopathy.

Am J Med Genet A 2020 04 11;182(4):713-720. Epub 2020 Jan 11.

Sheffield Clinical Genetics Service, Sheffield Children's NHS Foundation Trust, Sheffield, UK.

Developmental and Epileptic encephalopathies (DEE) describe heterogeneous epilepsy syndromes, characterized by early-onset, refractory seizures and developmental delay (DD). Several DEE associated genes have been reported. With increased access to whole exome sequencing (WES), new candidate genes are being identified although there are fewer large cohort papers describing the clinical phenotype in such patients. Read More

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http://dx.doi.org/10.1002/ajmg.a.61483DOI Listing

Effects of periconceptional folate on cognition in children of women with epilepsy: NEAD study.

Neurology 2020 02 23;94(7):e729-e740. Epub 2019 Dec 23.

From the Department of Neurology and Neurological Sciences (K.J.M.), Stanford University, CA; Department of Neurology (P.B.P.), Brigham and Women's Hospital, Harvard Medical School, Boston; The Emmes Corporation (R.C.M., C.A.B.), Rockville, MD; Walton Centre for Neurology & Neurosurgery (G.B.), University of Liverpool, Merseyside; Division of Evolution and Genomic Science (R.B.), School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, UK; Departments of Neurology and Pediatrics (D.W.L.), Emory University, Atlanta; and Pediatric Neuropsychology International (M.J.C.), Augusta, GA.

Objective: Emerging evidence suggests potential positive neuropsychological effects of periconceptional folate in both healthy children and children exposed in utero to antiseizure medications (ASMs). In this report, we test the hypothesis that periconceptional folate improves neurodevelopment in children of women with epilepsy by re-examining data from the Neurodevelopmental Effects of Antiepileptic Drugs (NEAD) study.

Methods: The NEAD study was an NIH-funded, prospective, observational, multicenter investigation of pregnancy outcomes in 311 children of 305 women with epilepsy treated with ASM monotherapy. Read More

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http://dx.doi.org/10.1212/WNL.0000000000008757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176294PMC
February 2020

Beyond the Epileptic Focus: Functional Epileptic Networks in Focal Epilepsy.

Cereb Cortex 2020 Apr;30(4):2338-2357

Epilepsy Program, Department of Neurology, Hospital Clínic, Neuroscience Institute, CP 08036, Barcelona, Spain.

Focal epilepsy can be conceptualized as a network disorder, and the functional epileptic network can be described as a complex system of multiple brain areas that interact dynamically to generate epileptic activity. However, we still do not fully understand the functional architecture of epileptic networks. We studied a cohort of 21 patients with extratemporal focal epilepsy. Read More

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http://dx.doi.org/10.1093/cercor/bhz243DOI Listing

Oromotor, word retrieval, and dichotic listening performance in young adults with previous Rolandic epilepsy.

Eur J Paediatr Neurol 2020 Mar 23;25:139-144. Epub 2019 Nov 23.

Department of Women's and Children's Health, Uppsala University Hospital, Uppsala, Sweden.

Aims: Results from a previous study indicated that children with Rolandic epilepsy (RE) exhibit abnormalities of oromotor and dichotic listening performance. The current study aimed to investigate whether the same individuals, 10 years later, still exhibited differences between the groups. Earlier literature suggests that children with RE normalize after remission and as they become adults. Read More

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http://dx.doi.org/10.1016/j.ejpn.2019.11.009DOI Listing

Establishing a Developmentally Appropriate fMRI Paradigm Relevant to Presurgical Mapping of Memory in Children.

Brain Topogr 2020 03 21;33(2):267-274. Epub 2019 Dec 21.

School of Life and Health Sciences, Aston Brain Centre, Aston University, Aston Triangle, Birmingham, B4 7ET, UK.

Functional magnetic resonance imaging (fMRI) is an established eloquent cortex mapping technique that is now an integral part of the pre-operative work-up in candidates for epilepsy surgery. Emerging evidence in adults with epilepsy suggests that material-specific fMRI paradigms can predict postoperative memory outcomes, however these paradigms are not suitable for children. In pediatric age, the use of memory fMRI paradigms designed for adults is complicated by the effect of developmental stages in cognitive maturation, the impairment experienced by some people with temporal lobe epilepsy (TLE) and the normal representation of memory function during development, which may differ from adults. Read More

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http://dx.doi.org/10.1007/s10548-019-00751-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066272PMC

Migraine Aura: Pathophysiology, Mimics, and Treatment Options.

Semin Neurol 2019 12 17;39(6):739-748. Epub 2019 Dec 17.

Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Recent insights into the clinical presentation and pathophysiology of migraine aura have paved the way for new treatments for this common but frequently debilitating condition. Marked efflux of cellular potassium and glutamate contributes to the cortical spreading depression that forms the electrophysiological basis of migraine aura phenomena. Secondary vascular perturbations also contribute to the various symptoms of a migraine attack. Read More

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http://dx.doi.org/10.1055/s-0039-1700525DOI Listing
December 2019

Unravelling the heterogeneity of epilepsy for optimal individualised treatment: advances in 2019.

Authors:
Page B Pennell

Lancet Neurol 2020 01;19(1):8-10

Department of Neurology, Harvard Medical School, Boston, MA 02115, USA; Division of Epilepsy and Division of Women's Health, Brigham and Women's Hospital, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(19)30430-2DOI Listing
January 2020

Management of epilepsy in pregnancy: a report from the International League Against Epilepsy Task Force on Women and Pregnancy.

Epileptic Disord 2019 Dec;21(6):497-517

Department of Neurology, Sree Chitra Tirunal Institute of Medical Sciences and Technology, Trivandrum, Kerala State, India.

The risks associated with use of antiepileptic drugs during pregnancy are a major concern for all women with epilepsy with childbearing potential. These risks have to be balanced against foetal and maternal risks associated with uncontrolled seizures. This report from the International League Against Epilepsy Task Force on Women and Pregnancy aims to provide a summary of relevant data on these risks as a basis for expert opinion recommendations for the management of epilepsy in pregnancy. Read More

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http://dx.doi.org/10.1684/epd.2019.1105DOI Listing
December 2019
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Management of status epilepticus in adults. Position paper of the Italian League against Epilepsy.

Epilepsy Behav 2020 01 22;102:106675. Epub 2019 Nov 22.

IRCCS Istituto delle Scienze Neurologiche, Bellaria Hospital, Bologna, Italy; Department of Biomedical and Neuromotor Sciences, University of Bologna, Italy. Electronic address:

Since the publication of the Italian League Against Epilepsy guidelines for the treatment of status epilepticus in 2006, advances in the field have ushered in improvements in the therapeutic arsenal. The present position paper provides neurologists, epileptologists, neurointensive care specialists, and emergency physicians with updated recommendations for the treatment of adult patients with status epilepticus. The aim is to standardize treatment recommendations in the care of this patient population. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.106675DOI Listing
January 2020