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Eur Heart J Case Rep 2021 Mar 4;5(3):ytab078. Epub 2021 Mar 4.

Division of Cardiology, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo 693-8501, Japan.

Background: In Wolff-Parkinson-White (WPW) syndrome, accessory atrioventricular pathways (AP) result in abnormal pre-excitation around the atrioventricular annuli and produce a dyssynchronous contraction of cardiac chambers. Identification of the AP affects the outcome of catheter ablation.

Case Summary: We report a case of WPW syndrome and paroxysmal atrial fibrillation in a 65-year-old man. Read More

Rom J Anaesth Intensive Care 2020 Jul 10;27(1):19-22. Epub 2020 Aug 10.

Department of Anaesthesiology and Reanimation, Derince Training and Research Hospital, Kocaeli, Turkey.

Background: Wolff-Parkinson-White (WPW) syndrome is a rare disease that can cause various patterns of tachyarrhythmias. The main goal of anaesthesiologists for the perioperative anaesthetic management of WPW patients must be to avoid sympathetic stimulation and prevent tachyarrhythmias.

Case: A 9-year-old male patient with a diagnosis of WPW syndrome, who underwent emergency surgery for supracondylar humerus fracture, is presented. Read More

Pediatr Ann 2021 Mar 1;50(3):e113-e120. Epub 2021 Mar 1.

Paroxysmal supraventricular tachycardia (SVT) is the most common clinical arrhythmia in young patients. With an estimated prevalence of roughly 1 in 500 children, a pediatrician may knowingly or unknowingly see several patients who are affected each year. SVT symptoms can sometimes be vague or conflated with common pediatric complaints. Read More

Heart Vessels 2021 May 19. Epub 2021 May 19.

Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

Although ventricular pre-excitation via accessory pathways (APs) causes cardiac dysfunction in children and young adults with Wolff-Parkinson-White (WPW) syndrome, the underlying cardiac dysfunction mechanisms are unclear. This study aimed to characterize cardiac dysfunction and clarify sensitive cardiac dysfunction indicators in WPW syndrome patients classified by the APs location with a layer-specific strain analysis. Twenty-four patients with WPW syndrome with a mean age of 14. Read More

Heart Views 2020 Oct-Dec;21(4):289-290. Epub 2021 Jan 14.

Division of Cardiology, West Vicenza General Hospitals, Arzignano, Vicenza, Italy.

We present a paradigmatic example of "cardiac memory," characterized by deep, giant, and negative T-waves in the inferior leads, after a successful ablation of a right-sided posteroseptal accessory pathway. Read More

J Cardiovasc Electrophysiol 2021 May 5. Epub 2021 May 5.

Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

J Emerg Trauma Shock 2020 Oct-Dec;13(4):312-316. Epub 2020 Dec 7.

Department of Emergency Medicine, Jawarharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

One of the rare causes of diffuse T-wave inversion (TWI) in electrocardiogram (ECG) is memory T-waves. This should be considered among the differentials of diffuse TWI in ECG of patients presenting to the emergency department (ED), especially when they have previous episodes of ventricular tachycardia (VT) or pacemaker implantation or Wolff-Parkinson-White syndrome. These TWIs are benign and do not require any treatment. Read More

IEEE Trans Med Imaging 2021 Apr 21;PP. Epub 2021 Apr 21.

Standard Electromechanical Wave Imaging isochrone generation relies on manual selection of zero-crossing (ZC) locations on incremental strain curves for a number of pixels in the segmented myocardium for each echocardiographic view and patient. When considering large populations, this becomes a time-consuming process, that can be limited by inter-observer variability and operator bias. In this study, we developed and optimized an automated ZC selection algorithm, towards a faster more robust isochrone generation approach. Read More

Strabismus 2021 Apr 15:1-5. Epub 2021 Apr 15.

School of Health Sciences, Institute of Clinical Sciences, University of Liverpool, Liverpool.

Care for children with acquired brain injury requires a multi-disciplinary team (MDT) to maximize rehabilitation. These children frequently present to the orthoptic clinic with complex difficulties impacting visual functions and eye movements. We report on one case which led to a reevaluation of our current assessment methods, clinical care pathways and the contents of clinic correspondence. Read More

Sci Rep 2021 Apr 13;11(1):8045. Epub 2021 Apr 13.

Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Hospital, 7-5-2, Kusunoki-Cho, Chuo-Ku, Kobe, Japan.

Cardiac accessory pathways (APs) in Wolff-Parkinson-White (WPW) syndrome are conventionally diagnosed with decision tree algorithms; however, there are problems with clinical usage. We assessed the efficacy of the artificial intelligence model using electrocardiography (ECG) and chest X-rays to identify the location of APs. We retrospectively used ECG and chest X-rays to analyse 206 patients with WPW syndrome. Read More

J Postgrad Med 2021 Apr 1. Epub 2021 Apr 1.

Department of Cardiology, Holy Family Hospital, Mumbai, Maharashtra, India.

Heart Rhythm 2021 Apr;18(4):651-652

Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, Michigan. Electronic address:

Clin Case Rep 2021 Mar 9;9(3):1315-1320. Epub 2021 Jan 9.

Department of Cardiology Tosei General Hospital Seto Japan.

Ultra-high-resolution mapping is useful in the ablation of accessory pathways. However, in patients with accessory pathways in the coronary sinus (CS) diverticulum, treatment with endocardial ablation may be challenging. Patients suspected of having subepicardial accessory pathways may require the examination of the venous anomaly using CS angiography. Read More

BMJ Case Rep 2021 Mar 25;14(3). Epub 2021 Mar 25.

Department of Anaesthesia and Intensive Care Unit, Hospital Queen Elizabeth 2, Kota Kinabalu, Sabah, Malaysia.

Wolff-Parkinson-White (WPW) syndrome is an extremely rare congenital cardiac conduction disorder. It is due to an aberrant pathway between the atrium and ventricle. This manuscript entails a man with an underlying WPW who was posted for an elective orchidectomy. Read More

Heart Rhythm 2021 Mar 16. Epub 2021 Mar 16.

Division of Cardiology, Department of Medicine, University of California, San Diego, La Jolla, California.

Background: Studies have suggested that a fasciculoventricular pathway (FVP) may be the cause of preexcitation in patients with Danon disease, a rare X-linked dominant genetic disorder of hypertrophic cardiomyopathy.

Objective: The purpose of this study was to describe the prevalence of ventricular preexcitation on resting 12-lead electrocardiogram (ECG) in patients with Danon disease and the electrophysiological study (EPS) results of those with preexcitation.

Methods: Patients with confirmed Danon disease diagnosed with preexcitation (PR ≤120 ms, delta wave, QRS >110 ms) on ECG were included from a multicenter registry. Read More

J Cardiol Cases 2021 Mar 4;23(3):115-118. Epub 2020 Nov 4.

Department of Cardiology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.

Patients with Wolff-Parkinson-White (WPW) syndrome rarely have multiple accessory pathways (APs). Here, we present a case of a 21-year-old man with the manifest type B WPW syndrome who was experiencing multiple attacks of palpitations. The electrophysiological study revealed two APs located bilaterally: the anterolateral tricuspid annulus and lateral mitral annulus. Read More

CJEM 2021 Mar 4;23(2):249-251. Epub 2021 Jan 4.

Department of Health Sciences, Carleton University, Ottawa, ON, K1S 5B6, Canada.

J Electrocardiol 2021 May-Jun;66:12-15. Epub 2021 Feb 24.

Department of Translational Medical Sciences, University "Federico II", Naples, Italy.

The Holter electrocardiogram from an asymptomatic man shows intermittent preexcitation. At the lowest rates all the QRS complexes display a WPW pattern. As the rate increases, preexcitation fails to occur and all the QRS complexes become persistently narrow. Read More

Cardiol Young 2021 Mar 4:1-4. Epub 2021 Mar 4.

Department of Pediatric Hematology, Van Yuzuncu Yil Universitiy, Van, Turkey.

Tuberous sclerosis complex is a rare multisystem genetic disorder characterised by the growth of numerous tumour-like malformations in many parts of the body including skin, kidneys, brain, lung, eyes, liver, and heart. Mutations in the TSC1 or TSC2 genes have been reported to cause disruption in the TSC1-TSC2 intracellular protein complex, causing over-activation of the mammalian target of rapamycin protein complex. In this study, we present a 3-month-old male infant diagnosed with tuberous sclerosis, bilateral neurosensorial hearing loss, Wolff-Parkinson-White syndrome on electrocardiography, multiple cardiac rhabdomyomas with severe stenosis in the left ventricular outflow tract, who responded well to the Everolimus therapy. Read More

J Cardiovasc Imaging 2021 Apr 15;29(2):175-178. Epub 2020 Sep 15.

Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

J Int Med Res 2021 Feb;49(2):300060520986676

Department of Cardiology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China.

Danon disease is a rare X-linked dominant genetic disorder caused by loss-of-function mutations in the lysosome-associated membrane protein 2 gene. Progression of Danon disease is unknown because of its rare incidence in a diverse ethnic population. We report longitudinal data from two patients who were diagnosed with Danon disease by a genetic test. Read More

BMC Med Genomics 2021 Jan 28;14(1):33. Epub 2021 Jan 28.

Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Mutations in the PRKAG2 gene encoding the 5' Adenosine Monophosphate-Activated Protein Kinase (AMPK), specifically in its γ2 regulatory subunit, lead to Glycogen storage disease of heart, fetal congenital disorder (PRKAG2 syndrome). These mutations are rare, and their functional roles have not been fully elucidated. PRKAG2 syndrome is autosomal dominant disorder inherited with full penetrance. Read More

Cardiol Res Pract 2021 5;2021:8841736. Epub 2021 Jan 5.

Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250012, Shandong, China.

Introduction: The relationship between ventricular pre-excitation and left ventricular dysfunction has been described in the absence of sustained supraventricular tachycardia in a series of case reports. However, there have been no systematic studies about the effect of ventricular pre-excitation on cardiac function in adult patients with different accessory pathway locations.

Methods And Results: Patients were divided into four groups based on the type and location of their accessory pathway: septal, right free wall, left free wall, and concealed. Read More

Herzschrittmacherther Elektrophysiol 2021 Mar 15;32(1):128-132. Epub 2021 Jan 15.

Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Liebigstraße 20, 04103, Leipzig, Deutschland.

We report the case of a 30-year-old man who presented to our emergency department with rapid heart beat and a narrow complex tachycardia at a rate of 215 beats per minute. With the working diagnosis of Wolf-Parkinson-White syndrome with paroxysmal orthodromic tachycardias, we performed an electrophysiological study. In this examination, there was a para-Hisian accessory pathway with very fast, prognostically relevant conduction properties. Read More

BMJ Open 2020 11 19;10(11):e038828. Epub 2020 Nov 19.

Internal Medicine, CHUV, Lausanne, Switzerland.

Objectives: P-wave duration (PWD) is associated with the development of atrial arrhythmias, cardiovascular and all-cause mortality. With this study, we aimed to assess the distribution and determinants of PWD in the general population.

Design: Cross-sectional study using data collected between 2014 and 2016. Read More

J Cardiol Cases 2021 Jan 6;23(1):31-34. Epub 2020 Oct 6.

Department of Cardiology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.

Direct-current (DC) cardioversion is effective at terminating arrhythmias in an emergency. During treatment, energy delivery synchronizing with the QRS complex is essential to avoid ventricular fibrillation (VF) caused by a shock on the T wave, which is the vulnerable period of ventricular repolarization. However, distinguishing the QRS from the T wave is difficult in some patients with abnormal, irregular, and varying QRS complexes. Read More

Pacing Clin Electrophysiol 2021 Feb 26;44(2):416-417. Epub 2021 Jan 26.

Department of Medical Sciences, Division of Cardiology, University of Turin, "Città della Salute e della Scienza" Hospital, Turin, Italy.

Case Rep Psychiatry 2020 11;2020:6633385. Epub 2020 Dec 11.

Department of Psychiatry and Behavioral Health, Penn State Hershey Medical Center, 500 University Drive P.O. Box 850. Mail Code R130. Hershey, PA 17033-0850, USA.

Quetiapine is occasionally associated with cardiovascular adverse effects such as QTc prolongation. QTc prolongation is a side effect that requires monitoring in order to avoid more serious cardiac complications. One particular understudied area is the potential for antipsychotics to elicit electroconduction abnormalities in patients with Wolff-Parkinson-White (WPW) Syndrome. Read More

HeartRhythm Case Rep 2020 Dec 7;6(12):947-950. Epub 2020 Oct 7.

University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, Spain.