28,544 results match your criteria Withdrawal Syndromes


Factors Associated With the Need for Pharmacological Management of Neonatal Opioid Withdrawal Syndrome.

Adv Neonatal Care 2020 Jul 7. Epub 2020 Jul 7.

Virginia Commonwealth University (VCU) School of Nursing, Richmond (Dr Scott); Pediatrix, Richmond, Virginia (Dr Scott); Indiana University School of Medicine and Indiana University Health Physicians, Indianapolis (Dr Guilfoy); Richard M. Fairbanks School of Public Health (Dr Duwve) and School of Nursing (Dr Rawl), Indiana University-Purdue University at Indianapolis.

Background: Neonatal opioid withdrawal syndrome (NOWS) is a significant and growing health problem that affects more than 23,000 infants annually, with an estimated hospital cost of more than $720 million.

Purpose: The purpose of this study was to examine factors associated with the need to initiate medication for the treatment of NOWS.

Methods: A retrospective review of medical records was conducted of 204 infants born to mothers who used opioids during pregnancy from April 2011 to September 2017. Read More

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http://dx.doi.org/10.1097/ANC.0000000000000772DOI Listing

Depletion of exosomal circLDLR in follicle fluid derepresses miR-1294 function and inhibits estradiol production via CYP19A1 in polycystic ovary syndrome.

Aging (Albany NY) 2020 Jul 10;12. Epub 2020 Jul 10.

Department of Assisted Reproduction, Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.

Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in reproductive women and is characterized by polycystic ovaries, hyperandrogenism and chronic anovulation. Abnormal folliculogenesis is considered as a common characteristic of PCOS. Our aim is to identify the altered circRNA expression profile in exosomes isolated from follicular fluid (FF) of PCOS patients to investigate the molecular function of exosomal circRNA, as a vital mediator in follicular microenvironment, in the aetiology and pathobiology of PCOS. Read More

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http://dx.doi.org/10.18632/aging.103602DOI Listing

The recognition and management of protracted alcohol withdrawal may improve and modulate the pharmacological treatment of alcohol use disorder.

J Psychopharmacol 2020 Jul 10:269881120936483. Epub 2020 Jul 10.

Department of Morphology, Surgery, Experimental Medicine, University of Ferrara, Ferrara, Italy.

About 50% of persons with an alcohol use disorder may have symptoms of alcohol withdrawal syndrome (AWS) when they reduce or discontinue their alcohol consumption. Protracted alcohol withdrawal (PAW), an underestimated and not yet clearly defined clinical condition that follows the acute stage of AWS, is characterized by the presence of substance-specific signs and symptoms (i.e. Read More

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http://dx.doi.org/10.1177/0269881120936483DOI Listing

Clinical exacerbation of SARS-CoV2 infection after fingolimod withdrawal.

J Med Virol 2020 Jul 9. Epub 2020 Jul 9.

Department of Neurology, Institute of Neurosciences, IdISSC, Hospital Clínico San Carlos. Plz. Prof. Martin Lagos s/n, Madrid, 28040, Spain.

The role of disease-modifying therapies in patients with autoimmune disorders during SARS-CoV2 infection is controversial. Immunocompromised patients could have a more severe COVID-19 disease, due to the absence of an adequate immune response against the SARS-CoV-2. However, therapies that act on immune response could play a protective role by dampening the cytokine release syndrome. Read More

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http://dx.doi.org/10.1002/jmv.26279DOI Listing

Olanzapine-Induced Withdrawal Oculogyric Crisis in an Adolescent With a Neurodevelopmental Disorder.

J Pediatr Pharmacol Ther 2020 ;25(5):455-458

This case report describes an adolescent female with a complex psychiatric history and Fragile X syndrome who developed an antipsychotic-withdrawal emergent oculogyric crisis (OGC) in approximately 12 hours following reduction in olanzapine dose from 20 mg total daily dose to 5 mg twice daily. The team concluded that the OGC was likely related to olanzapine withdrawal based on the following clinical factors: 1) prior treatment with olanzapine 20 mg for 4 to 5 days/week for several months, without such reaction; 2) proximity of the OGC to the olanzapine dose reduction (within 12 hours); and 3) lack of recurrence with olanzapine dose increase. Additionally, her neurodevelopmental disorder and age were identified as risk factors for an acute dystonic reaction. Read More

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http://dx.doi.org/10.5863/1551-6776-25.5.455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337127PMC
January 2020

Feasibility of auricular acupressure as an adjunct treatment for neonatal opioid withdrawal syndrome (NOWS).

Subst Abus 2020 Jul 7:1-10. Epub 2020 Jul 7.

Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN, USA.

The opioid epidemic in the United States continues to threaten public health. As a result of this crisis, neonatal opioid withdrawal syndrome (NOWS) has risen exponentially and requires a multitude of non-pharmacologic treatments to ensure healthy neonatal outcomes. This feasibility study implemented an acupressure protocol as informed by the Near-Term Infant (NTI) conceptual framework for the treatment of NOWS. Read More

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http://dx.doi.org/10.1080/08897077.2020.1784360DOI Listing

The Characteristics and Social Functioning of Pathological Social Withdrawal, "Hikikomori," in a Secondary Care Setting: a One-Year Cohort Study.

BMC Psychiatry 2020 Jul 6;20(1):352. Epub 2020 Jul 6.

Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine / School of Public Health, Yoshida Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.

Background: Pathological social withdrawal, named "Hikikomori," is a Japanese culture-bound syndrome and a serious social problem in Japan. The number of Hikikomori cases in Japan was estimated at about 563,000 in 2016 according to governmental surveys. However, no studies have reported how many people with Hikikomori have access to community-based psychiatry clinics, and how different they are from non-Hikikomori patients regarding their baseline characteristics and outcomes. Read More

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http://dx.doi.org/10.1186/s12888-020-02660-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336612PMC

Anakinra in the treatment of protracted paradoxical inflammatory reactions in HIV-associated tuberculosis in the United Kingdom: a report of two cases.

Int J STD AIDS 2020 Jul;31(8):808-812

Department of Rheumatology, Sheffield Teaching Hospitals NHS Foundation Trust and Sheffield Children's Hospital NHS Foundation Trust, Sheffield, UK.

Paradoxical reactions, including immune reconstitution inflammatory syndrome (IRIS), are common in patients co-infected with human immunodeficiency virus (HIV) and tuberculosis (TB). Paradoxical reactions may confer substantial morbidity and mortality, especially in cases of central nervous system (CNS) TB, or through protracted usage of corticosteroids. No high-quality evidence is available to guide management in this scenario. Read More

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http://dx.doi.org/10.1177/0956462420915394DOI Listing

Maternal Poppy Seed Tea Ingestion and Ensuing Neonatal Abstinence Syndrome.

Neonatology 2020 Jul 6:1-3. Epub 2020 Jul 6.

Pediatrix Medical Group, San Antonio, Texas, USA,

The incidence of neonatal abstinence syndrome has been rising in the USA. Nonpharmacological treatments resulting in similar withdrawal states in the newborn have also been described. We report an infant with neonatal abstinence syndrome born to a mother with daily poppy seed tea ingestion for the self-treatment of nausea. Read More

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http://dx.doi.org/10.1159/000508446DOI Listing

[Bioregulatory drugs in the prevention of complications in the early postoperative period in patients after septoplasty and FESS].

Authors:
I M Kirichenko

Vestn Otorinolaringol 2020 ;85(3):64-67

Peoples' Friendship University of Russia, Moscow, Russia.

Objective: To evaluate the effectiveness of the use of bioregulatory drugs for the prevention of complications in the early postoperative period in patients after septoplasty and FESS.

Patients And Methods: We performed surgical treatment of 25 patients with chronic rhinosinusitis with frequent exacerbations without polyps. The extent of operation was septoplasty and FESS (polysinusotomy). Read More

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http://dx.doi.org/10.17116/otorino20208503164DOI Listing
January 2020

Marijuana Use for Women: To Prescribe or Not to Prescribe.

Subst Use Misuse 2020 Jul 5:1-2. Epub 2020 Jul 5.

Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

The marijuana policy varies greatly worldwide. Marijuana use is illegal in most countries. Nevertheless, the medical potentials of marijuana have been increasingly uncovered, and its use by women is increasing. Read More

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http://dx.doi.org/10.1080/10826084.2020.1782938DOI Listing

Effect of Setmelanotide, an MC4R Agonist, on Obesity in Bardet-Biedl Syndrome.

Diabetes Obes Metab 2020 Jul 6. Epub 2020 Jul 6.

Section on Growth and Obesity, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.

Aims: Bardet-Biedl syndrome (BBS) is characterized by early-onset obesity and hyperphagia. Setmelanotide decreases weight and hunger in individuals with rare genetic disorders of obesity. We report results of an open-label single-arm phase 2 study of setmelanotide in BBS (ClinicalTrials. Read More

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http://dx.doi.org/10.1111/dom.14133DOI Listing

[Hormones of stress-response system in alcohol dependence: the ability to predict duration of remission].

Zh Nevrol Psikhiatr Im S S Korsakova 2020 ;120(5):73-78

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.

Objective: To determine the spectrum of hormones of the stress-realizing system in the time course of therapy of withdrawal syndrome and post-withdrawal state and analyze their possible relationships with the duration of therapeutic remission in patients with alcohol dependence.

Material And Methods: The examination included 74 men admitted in the clinic at Mental Health Research Institute NRMC diagnosed as having «Mental and behavioral disorders due to use of alcohol» (dependence syndrome F10.21 and withdrawal state - F10. Read More

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http://dx.doi.org/10.17116/jnevro202012005173DOI Listing

Causes and characteristics of death in patients with acute hypoxemic respiratory failure and acute respiratory distress syndrome: a retrospective cohort study.

Crit Care 2020 Jul 3;24(1):391. Epub 2020 Jul 3.

Department of Internal Medicine, University of Michigan, 1500 East Medical Center Drive, Taubman Center, Ann Arbor, MI, 48109, USA.

Background: Acute hypoxemic respiratory failure (AHRF) and acute respiratory distress syndrome (ARDS) are associated with high in-hospital mortality. However, in cohorts of ARDS patients from the 1990s, patients more commonly died from sepsis or multi-organ failure rather than refractory hypoxemia. Given increased attention to lung-protective ventilation and sepsis treatment in the past 25 years, we hypothesized that causes of death may be different among contemporary cohorts. Read More

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http://dx.doi.org/10.1186/s13054-020-03108-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332537PMC

Electroacupuncture Improves IBS Visceral Hypersensitivity by Inhibiting the Activation of Astrocytes in the Medial Thalamus and Anterior Cingulate Cortex.

Evid Based Complement Alternat Med 2020 12;2020:2562979. Epub 2020 Jun 12.

Key Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai 200030, China.

Objective: To explore whether the effect of electroacupuncture (EA) on visceral hypersensitivity (VH) in rats with irritable bowel syndrome (IBS) is related to the changes of astrocyte activation in the medial thalamus (MT) and anterior cingulate cortex (ACC).

Method: Male Sprague-Dawley rats were randomly divided into the normal control (NC) group, model control (MC) group, electroacupuncture (EA) group, and fluorocitrate (FCA) group. A model of visceral hypersensitivity was established by neonatal colorectal irritation. Read More

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http://dx.doi.org/10.1155/2020/2562979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306073PMC

[Effects of N-methyl-D-aspartate Receptor in Keratinocyte on TypeⅠComplex Regional Pain Syndrome].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2020 Jun;42(3):338-346

Department of Anesthesiology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.

To observe the cell origin of N-methyl-D-aspartic acid(NMDA)receptor expression in skin after chronic ischemic pain modeling in rats and explore the role of NMDA receptor in type Ⅰ complex regional pain syndrome. Forty-two adult male Sprague-Dawley rats were randomly divided into five groups:sham operation group(=12),chronic post ischemia pain(CPIP)group(=12),CPIP+normal saline(NS)group(=6),CPIP+NMDA group(=6),and CPIP+MK801 group(=6).Six rats in the sham operation group and CPIP group were sacrificed under deep anesthesia one day after modeling. Read More

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http://dx.doi.org/10.3881/j.issn.1000-503X.12002DOI Listing

Fatal outcome in a patient under immunosuppressant therapy infected with human T-lymphotropic virus type 1 (HTLV-1), cytomegalovirus (CMV) and Strongyloides stercoralis: a case report.

BMC Infect Dis 2020 Jul 2;20(1):470. Epub 2020 Jul 2.

Department of Hematology and Rheumatology, Kindai University School of Medicine, 377-2 Oonohigashi, Osaka-Sayama, Osaka, 589-0014, Japan.

Background: Strongyloidiasis is a gastrointestinal parasitic infection caused by percutaneous infection with Strongyloides stercoralis. Digestive symptoms such as diarrhea and abdominal pain are the main manifestation, but serious infections such as septicemia, purulent meningitis, and bacterial pneumonia may occur in individuals harboring human T-lymphotropic virus type 1 (HTLV-1) or who are immunocompromised. Although coinfection with Strongyloides stercoralis and HTLV-1 can lead to chronic strongyloidiasis and a disseminated form of the disease, there is a high rate of response to the anthelmintic ivermectin. Read More

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http://dx.doi.org/10.1186/s12879-020-05195-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331000PMC

Learning Experiences Comprising Central Ethanol Exposure in Rat Neonates: Impact Upon Respiratory Plasticity and the Activity of Brain Catalase.

Alcohol 2020 Jun 29. Epub 2020 Jun 29.

Instituto de Investigación Médica M. y M. Ferreyra (INIMEC - CONICET - UNC), Córdoba, Argentina. Electronic address:

Fetal ethanol exposure represents a risk factor for the Sudden Infant Death Syndrome and its respiratory effects promote hypoxic ischemic consequences. This study analyzes central ethanol's effects upon breathing plasticity during an ontogenetic stage equivalent to the third human gestational trimester. Ethanol's unconditioned breathing effects and their intervention in learning processes were examined. Read More

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http://dx.doi.org/10.1016/j.alcohol.2020.06.004DOI Listing

Effects of statins and exercise on postprandial lipoproteins in metabolic syndrome vs metabolically healthy individuals.

Br J Clin Pharmacol 2020 Jun 29. Epub 2020 Jun 29.

Exercise Physiology Lab at Toledo, University of Castilla-La Mancha, Spain.

Aims: To determine if the combination of exercise and statin could normalize postprandial triglyceridaemia (PPTG) in hypercholesteraemic individuals.

Methods: Eight hypercholesteraemic (blood cholesterol 182 ± 38 mg dL ; low-density lipoprotein-cholesterol [LDL-c] 102 ± 32 mg dL ) overweight (body mass index 30 ± 4 kg m ) individuals with metabolic syndrome (MetS) were compared to a group of 8 metabolically healthy (MetH) controls (blood cholesterol 149 ± 23 mg dL ; LDL-c 77 ± 23 mg dL , and body mass index 23 ± 2 kg m ). Each group underwent 2 PPTG tests, either 14 hours after a bout of intense exercise or without previous exercise. Read More

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http://dx.doi.org/10.1111/bcp.14447DOI Listing

Gamma-hydroxybutyrate abuse: pharmacology and poisoning and withdrawal management.

Arh Hig Rada Toksikol 2020 Mar;71(1):19-26

Department of Anatomical, Histological, Forensic, and Orthopaedic Sciences,Sapienza University of Rome, Rome, Italy.

Gamma-hydroxybutyrate (GHB) is a central nervous system depressant primarily used as a recreational drug of abuse, but also for the treatment of narcolepsy with cataplexy in adult patients and as an adjuvant for control of alcohol withdrawal syndrome. The main aim of this review is to summarise updated knowledge about GHB pharmacokinetics and pharmacodynamics, acute poisoning, and clinical features of GHB withdrawal syndrome, its diagnosis and medical treatment. The most common clinical signs and symptoms of acute poisoning include sleepiness to deep coma, bradycardia, hypotension, and respiratory failure. Read More

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http://dx.doi.org/10.2478/aiht-2020-71-3314DOI Listing

Similar names, different results: Consistency of the associations between prenatal exposure to phthalates and parent-ratings of behavior problems in preschool children.

Environ Int 2020 Sep 25;142:105892. Epub 2020 Jun 25.

Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Owerko Centre, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, Calgary, Alberta, Canada.

Background: Environmental health research has reported mixed findings on the associations between prenatal exposure to phthalates and parent-ratings of child behavioral problems.

Objective: We examined the consistency of the associations between prenatal urinary phthalate concentrations and child behavior scores across two standardized instruments - the Behavior Assessment System for Children-Second Edition (BASC-2) and the Child Behavior Checklist (CBCL) - using two analytical approaches used to correct for urine dilution.

Method: A sample of 351 mother-child pairs were selected from a prospective birth cohort of pregnant women enrolled between 2009 and 2012. Read More

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http://dx.doi.org/10.1016/j.envint.2020.105892DOI Listing
September 2020
5.559 Impact Factor

Usefulness of intravitreal dexamethasone implant in the management of «Vogt-Koyanagi-Harada-like syndrome» secondary to map kinase pathway inhibition.

Arch Soc Esp Oftalmol 2020 Jun 24. Epub 2020 Jun 24.

Hospital Campo Aarañuelo, Navalmoral de la Mata, Cáceres, España.

The case is presented of a 58-year-old woman with a personal history of metastatic melanoma under treatment with trametinib and dabrafenib, as well as a decrease in bilateral visual acuity. On examination, it was observed that she had an anterior uveitis, vitritis, serous retinal detachment, vasculitis and disc oedema in both eyes. She was diagnosed with a Vogt-Koyanagi-Harada-like syndrome secondary to MAP kinase pathway inhibition. Read More

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http://dx.doi.org/10.1016/j.oftal.2020.05.014DOI Listing

Strategies for the Prevention and Treatment of Iatrogenic Withdrawal from Opioids and Benzodiazepines in Critically Ill Neonates, Children and Adults: A Systematic Review of Clinical Studies.

Drugs 2020 Jun 26. Epub 2020 Jun 26.

Pharmacy Department, McGill University Health Centre, Montreal, Canada.

Background: Critically ill patients are at high risk of iatrogenic withdrawal syndrome (IWS), due to exposure to high doses or prolonged periods of opioids and benzodiazepines.

Purpose: To examine pharmacological management strategies designed to prevent and/or treat IWS from opioids and/or benzodiazepines in critically ill neonates, children and adults.

Methods: We included non-randomised studies of interventions (NRSI) and randomised controlled trials (RCTs), reporting on interventions to prevent or manage IWS in critically ill neonatal, paediatric and adult patients. Read More

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http://dx.doi.org/10.1007/s40265-020-01338-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317263PMC

COVID-19 pneumonia and immune-related pneumonitis: critical issues on differential diagnosis, potential interactions, and management.

Expert Opin Biol Ther 2020 Jul 2:1-5. Epub 2020 Jul 2.

Department of Medical Oncology, University Campus Bio-Medico , Rome, Italy.

Introduction: The COVID-19 pandemic occurred amid the cancer immunotherapy revolution. Immune checkpoint inhibitors (ICIs) have become the standard of care for several solid cancers and are associated with peculiar toxicities, including pneumonitis which has similar features to COVID-19 pneumonia.

Areas Covered: We summarize the main hallmarks of lung injury induced by ICIs and severe acute respiratory syndrome coronavirus 2 and discuss the critical aspects for differential diagnosis and management. Read More

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http://dx.doi.org/10.1080/14712598.2020.1789097DOI Listing

Randomised controlled trial comparing efficacy and safety of high versus low Low-Molecular Weight Heparin dosages in hospitalized patients with severe COVID-19 pneumonia and coagulopathy not requiring invasive mechanical ventilation (COVID-19 HD): a structured summary of a study protocol.

Trials 2020 Jun 26;21(1):574. Epub 2020 Jun 26.

Servizio Formazione, Ricerca e Innovazione, Azienda Ospedaliero-Universitaria di Modena, Ospedale Policlinico, Modena, Italy.

Objectives: To assess whether high doses of Low Molecular Weight Heparin (LMWH) (i.e. Enoxaparin 70 IU/kg twice daily) compared to standard prophylactic dose (i. Read More

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http://dx.doi.org/10.1186/s13063-020-04475-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316577PMC

Osmotic Demyelination Syndrome Despite Appropriate Hyponatremia Correction.

Cureus 2020 May 20;12(5):e8209. Epub 2020 May 20.

Radiology, St. Barnabas Hospital Health System, Albert Einstein College of Medicine, Bronx, USA.

Acute demyelination of the pons or extrapontine areas results in an osmotic demyelination syndrome (ODS), previously referred to as central pontine myelinolysis (CPM) or extra pontine myelinolysis (EPM). It is caused by osmotic dysregulation in the brain. Multiple risk factors have been known to contribute to these osmotic disturbances. Read More

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http://dx.doi.org/10.7759/cureus.8209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305570PMC

Late renal recovery after treatment over 1 year post-onset in an atypical hemolytic uremic syndrome: a case report.

BMC Nephrol 2020 Jun 22;21(1):236. Epub 2020 Jun 22.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: Atypical hemolytic uremic syndrome (aHUS) is a life-threatening disease that leads to end-stage kidney disease if only a poor response to plasma exchanges (PEs) or eculizumab therapy is achieved.

Case Presentation: A 58-year-old Japanese man presented with thrombocytopenia, anemia, and kidney failure requiring dialysis without any underlying disease. A kidney biopsy revealed marked mesangiolysis in all glomeruli, compatible with thrombotic microangiopathy (TMA). Read More

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http://dx.doi.org/10.1186/s12882-020-01897-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310110PMC

Acute Opioid Withdrawal Mimicking Postoperative Joint Infection Following anterior cruciate ligament (ACL) Reconstruction: A Case Report.

Am J Case Rep 2020 Jun 22;21:e923458. Epub 2020 Jun 22.

Department of Orthopedic Surgery, Thomas Jefferson University Hospital, Rothman Institute, Philadelphia, PA, USA.

BACKGROUND A short course of opioid narcotics is often prescribed for postoperative anterior cruciate ligament (ACL) reconstruction pain management. Unfortunately, there is a well-documented incidence of opioid withdrawal syndrome (OWS) following short-term use of these medications. OWS can present with symptoms such as influenza-like illness. Read More

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http://dx.doi.org/10.12659/AJCR.923458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327734PMC

DARK Classics in Chemical Neuroscience: Heroin and Desomorphine.

ACS Chem Neurosci 2020 Jul 7. Epub 2020 Jul 7.

Bioactive Heterocycles Synthesis Laboratory, BHSL, Departamento de Farmacia, Facultad de Quı́mica y de Farmacia, Pontificia Universidad Católica de Chile, Casilla 306, Avda. Vicuña Mackenna 4860, Macul, 7820436 Santiago, Chile.

Opioids are arguably one of the most important pharmacologic classes, mainly due to their rich history, their useful and potent analgesic effects, and also, just as importantly, their "Dark Side", constituted by their reinforcing properties that have led countless of users to a spiral of addiction, biological dependence, tolerance, withdrawal syndromes, and death. Among the most significant abused and addictive known opioids are heroin and desomorphine, both synthetic derivatives of morphine that belong to the 4,5-epoxymorphinan structural chemical group of the opioid family drugs. These agents share not only structural, pharmacological, and epidemiological features but also a common geographical distribution. Read More

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http://dx.doi.org/10.1021/acschemneuro.0c00262DOI Listing

TEMPORARY REMOVAL: Quantification of changes in eyelid position in patients with dry eye syndrome: A randomized, placebo-controlled multicenter study of application of topical anesthetic.

Dis Mon 2020 Jun 17:101026. Epub 2020 Jun 17.

Division of Ophthalmology, NorthShore University HealthSystem, Evanston, IL, USA; Department of Ophthalmology and Visual Science, University of Chicago, Chicago, IL, USA. Electronic address:

The Publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. The full Elsevier Policy on Article Withdrawal can be found at https://www. Read More

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http://dx.doi.org/10.1016/j.disamonth.2020.101026DOI Listing
June 2020
0.535 Impact Factor

DNA methylation and BDNF expression account for symptoms and widespread hyperalgesia in patients with Chronic Fatigue Syndrome and Fibromyalgia.

Arthritis Rheumatol 2020 Jun 20. Epub 2020 Jun 20.

Pain in Motion (PiM) international research group, Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Rehabilitation Sciences & Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium.

Background: Epigenetics of neurotrophic factors holds the potential to unravel the mechanisms underlying the pathophysiology of complex conditions such as chronic fatigue syndrome (CFS). This study explored the role of brain-derived neurotrophic factor (BDNF) genetics, epigenetics, and protein expression in patients with both CFS and comorbid fibromyalgia (CFS/FM).

Methods: A repeated-measures study in 54 participants (28 patients with CFS/FM and 26 matched healthy controls) was conducted. Read More

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http://dx.doi.org/10.1002/art.41405DOI Listing

Psychiatric Manifestation of Anti-LGI1 Encephalitis.

Brain Sci 2020 Jun 16;10(6). Epub 2020 Jun 16.

Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.

Background: Anti-leucine-rich glioma-inactivated 1 (LGI1) encephalitis is typically characterized by limbic encephalitis, faciobrachial dystonic seizures and hyponatremia. The frequency with which milder forms of anti-LGI1 encephalitis mimic isolated psychiatric syndromes, such as psychoses, or may lead to dementia if untreated, is largely unknown.

Case Presentation: Here, the authors present a 50-year-old patient who had suffered from neurocognitive deficits and predominant delusions for over one and a half years. Read More

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http://dx.doi.org/10.3390/brainsci10060375DOI Listing

Short-term nicotine deprivation alters dorsal anterior cingulate glutamate concentration and concomitant cingulate-cortical functional connectivity.

Neuropsychopharmacology 2020 Jun 19. Epub 2020 Jun 19.

Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.

Most cigarette smokers who wish to quit too often relapse within the first few days of abstinence, primarily due to the aversive aspects of the nicotine withdrawal syndrome (NWS), which remains poorly understood. Considerable research has suggested that the dorsal anterior cingulate cortex (dACC) plays a key role in nicotine dependence, with its functional connections between other brain regions altered as a function of trait addiction and state withdrawal. The flow of information between dACC and fronto-striatal regions is secured through different pathways, the vast majority of which are glutamatergic. Read More

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http://dx.doi.org/10.1038/s41386-020-0741-9DOI Listing

Integrative Review of Gut Microbiota and Expression of Symptoms Associated with Neonatal Abstinence Syndrome.

Nurs Res 2020 Jun 15. Epub 2020 Jun 15.

The Ohio State University, Columbus, Ohio The Ohio State University, Columbus, OH The Ohio State University, Columbus, Ohio The Ohio State University, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio.

Background: Neonatal exposure and subsequent withdrawal from maternal substance use disorder is a growing problem and consequence of the current opioid epidemic. Neonatal abstinence syndrome is defined by a specified cluster of symptoms with treatment guided by the expression and severity of these symptoms. The mechanisms or pathophysiology contributing to the development of neonatal abstinence syndrome symptoms are not well known, but one factor that may influence NAS symptoms is the gut microbiota. Read More

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http://dx.doi.org/10.1097/NNR.0000000000000452DOI Listing

Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with SARS-CoV-2 Infection: A Multi-institutional Study from New York City.

J Pediatr 2020 Jun 14. Epub 2020 Jun 14.

Department of Pediatrics, Division of Pediatric Critical Care Medicine, Albert Einstein College of Medicine, Children's Hospital at Montefiore; Department of Pediatrics, Division of Pediatric Cardiology, Albert Einstein College of Medicine, Children's Hospital at Montefiore. Electronic address:

Objective: To assess clinical characteristics and outcomes of SARS-CoV-2 associated multisystem inflammatory syndrome in children (MIS-C).

Study Design: Children with MIS-C admitted to pediatric intensive care units (PICU) in New York City between April 23 and May 23, 2020 were included. Demographic and clinical data were collected. Read More

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http://dx.doi.org/10.1016/j.jpeds.2020.06.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293760PMC
June 2020
3.790 Impact Factor

Netrin-1 contributes to peripheral nerve injury induced neuropathic pain via regulating phosphatidylinositol 4-kinase IIa in the spinal cord dorsal horn in mice.

Neurosci Lett 2020 Jun 15;735:135161. Epub 2020 Jun 15.

Department of Anesthesiology, Tianjin First Center Hospital, Tianjin 300192, China. Electronic address:

Background: The burden of neuropathic pain is growing worldwide. Recent studies recapitulate the requirement for AMPA receptor in excitatory synaptic plasticity underlying pain-related syndromes. Netrin-1 and its receptor deleted in colorectal cancer (DCC) are fundamental for AMPA receptor dependent synaptic transmission. Read More

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http://dx.doi.org/10.1016/j.neulet.2020.135161DOI Listing

Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages.

Front Neurol 2020 29;11:446. Epub 2020 May 29.

Memory and Aging Center, University of California, San Francisco, San Francisco, CA, United States.

During early stages, patients with neurodegenerative diseases (NDG) often present with depressive symptoms. However, because depression is a heterogeneous disorder, more precise delineation of the specific depressive symptom profiles that arise early in distinct NDG syndromes is necessary to enhance patient diagnosis and care. Five-hundred and sixty four participants self-reported their depressive symptoms using the Geriatric Depression Scale (GDS), including 111 healthy older control subjects (NC) and 453 patients diagnosed with one of six NDGs who were at the mild stage of disease (CDR® Dementia Staging Instrument ≤ 1) [186 Alzheimer's disease (AD), 76 behavioral variant frontotemporal dementia (bvFTD), 52 semantic variant primary progressive aphasia (svPPA), 46 non-fluent variant PPA (nfvPPA), 49 progressive supranuclear palsy syndrome (PSPS), 44 corticobasal syndrome (CBS)]. Read More

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http://dx.doi.org/10.3389/fneur.2020.00446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273507PMC

Cognitive flexibility and flexibility in coping in nurses - the moderating role of age, seniority and the sense of stress.

Int J Occup Med Environ Health 2020 Jun 10;33(4):507-521. Epub 2020 Jun 10.

Provincial Hospital for Nervous and Mental Illnesses, Świecie, Poland (Department for the Treatment of Withdrawal Syndromes after Psychoactive Substances).

Objectives: The nursing profession entails many stressful situations and challenges, such as heavy workload, shift work, emotional demands and professional conflicts. In the light of the results of the research conducted so far, flexible coping has occurred to be highly adaptive, as its association with adaptive struggle with the disease, fewer depressive symptoms and both greater mental well-being and better health have been proven. In connection with the above, the aim of this study was to determine the nature of the relationship between cognitive flexibility and flexibility in coping in nurses, taking into account the moderating role of age of the respondents, seniority and the sense of stress. Read More

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http://dx.doi.org/10.13075/ijomeh.1896.01567DOI Listing

Withdrawing mycophenolate mofetil in treating a young kidney transplant recipient with COVID-19: A case report.

Medicine (Baltimore) 2020 Jun;99(24):e20481

Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan.

Rationale: Coronavirus disease 2019 (COVID-19) is a novel infectious disease and became a global issue. Treatment of COVID-19 especially in solid organ transplant recipients is empirical and controversial, especially the adjustment of the immunosuppressants.

Patient Concerns: A 29-year-old kidney transplant recipient with the symptoms of COVID-19 pneumonia. Read More

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http://dx.doi.org/10.1097/MD.0000000000020481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302670PMC

Withdrawn: Letter to editor in response to "COVID-19: From bench to bedside" by Singh A et al.

Diabetes Metab Syndr 2020 Jun 12;14(5):815-816. Epub 2020 Jun 12.

Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India. Electronic address:

The Publisher regrets that this article is an accidental duplication of an article that has already been published in Diabetes & Metabolic Syndrome: Clinical Research & Reviews, volume 14 (2020) 807 first page - 807 last page, https://doi.org/10.1016/j. Read More

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http://dx.doi.org/10.1016/j.dsx.2020.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289733PMC

Make Mission Impossible Feasible: The Experience of a Multidisciplinary Team Providing Treatment for Alcohol Use Disorder to Homeless Individuals.

Alcohol Alcohol 2020 Jun 13. Epub 2020 Jun 13.

Internal Medicine and Alcohol Related Disease Unit, Department of Internal Medicine and Gastroenterology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Aim: People experiencing homelessness are often excluded from treatment programs for alcohol use disorder (AUD). The goal of this study was to describe the impact of a multidisciplinary treatment program on alcohol consumption and social reintegration in individuals with AUD experiencing homelessness.

Methods: Thirty-one individuals with AUD experiencing homelessness were admitted to an inpatient unit for 5-6 days for clinical evaluation and to treat potential alcohol withdrawal syndrome. Read More

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http://dx.doi.org/10.1093/alcalc/agaa052DOI Listing

Detection of Transient Increase of Cerebral Blood Flow and Reversible Neuronal Dysfunction by Iodine-123-iomazenil SPECT Following Cerebral Hyperperfusion Syndrome after Revascularization Surgery for Moyamoya Disease.

World Neurosurg 2020 Jun 8. Epub 2020 Jun 8.

Department of Neurosurgery, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan. Electronic address:

Background: and Importance: Early and late images of single photon emission computed tomography (SPECT) using I-iomazenil (I-IMZ) can demonstrate cerebral blood flow and cortical neuronal viability, respectively. Hyperperfusion syndrome is one of the serious complications after revascularization surgery for moyamoya disease; therefore, the real-time observation of the hemodynamics and neuronal viability is important for the treatment after the revascularization. Here we report, a case of moyamoya disease in whom I-IMZ SPECT had a significant efficacy to delineate the hemodynamics and transient neuronal dysfunction in hyperperfusion state after revascularization. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.06.014DOI Listing

The stair-step approach in treatment of anovulatory PCOS patients.

Ther Adv Reprod Health 2020 Jan-Dec;14:2633494120908818. Epub 2020 May 22.

IVF Unit, Department of Obstetrics and Gynecology, Wolfson Medical Center, Holon 58100, Israel.

Clomiphene citrate (CC) is a widely accepted first-line treatment for anovulatory patients with polycystic ovarian syndrome (PCOS). The current practice is to prescribe CC with gradual dose increments until ovulation is achieved. Typically, progesterone withdrawal bleeding is induced between each dose increment and before the commencement of gonadotropin therapy in CC-resistant patients. Read More

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http://dx.doi.org/10.1177/2633494120908818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254579PMC

Withdrawal seizures: possible risk factors.

Expert Rev Neurother 2020 Jun 23:1-6. Epub 2020 Jun 23.

Department of Pediatrics, University of L'Aquila , L'Aquila, Italy.

Introduction: Most of the patients usually achieve seizure freedom under treatment with antiseizure medications (ASMs). Drug withdrawal in seizure-free patients is still one of the most challenging issues in the management of epilepsy. The decision-making process of whether the treatment should be discontinued must be based on the evaluation of possible long-term side effects of chronic treatment and, on the other hand, the risk of seizure relapse. Read More

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http://dx.doi.org/10.1080/14737175.2020.1780917DOI Listing

Active chlordiazepoxide metabolites in a patient needing life support after treatment of alcohol abstinence.

Basic Clin Pharmacol Toxicol 2020 Jun 8. Epub 2020 Jun 8.

Department of Forensic Medicine, Aarhus University, Aarhus, Denmark.

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http://dx.doi.org/10.1111/bcpt.13449DOI Listing

Electroacupuncture relieves irritable bowel syndrome by increasing expression of nucleotide-binding oligomerization domain protein-like receptor family pyrin domain containing 6 in water-avoidance stress mice.

J Tradit Chin Med 2020 Jun;40(3):407-413

Department of the First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China.

Objective: To investigate the effect of electroacupuncture (EA) on irritable bowel syndrome (IBS) in mice through regulating nucleotide-binding oligomerization domain protein-like receptor family pyrin domain containing 6 (NLRP6).

Methods: Water-avoidance stress (WAS) mice model was used to investigate the effects and the mechanism of EA. Abdominal withdrawal reflex test, open field test, and intestinal motility test were used to evaluate visceral sensitivity, anxiety, and intestinal motility in mice. Read More

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http://dx.doi.org/10.19852/j.cnki.jtcm.2020.03.007DOI Listing

The Mechanism and Clinical Outcome of patients with Corona Virus Disease 2019 Whose Nucleic Acid Test has changed from negative to positive, and the therapeutic efficacy of Favipiravir: A structured summary of a study protocol for a randomised controlled trial.

Trials 2020 Jun 5;21(1):488. Epub 2020 Jun 5.

Department of Infectious Disease, Center for Liver Disease, Peking University First Hospital, No.8 Xishiku Street, Xicheng District, Beijing, China.

Objectives: A variety of possible mechanisms can make the nucleic acid test of patients who meet the discharge conditions positive again, including reinfection, reactivation of the original virus, lack of strict discharge criteria, new infection, and so on. Different reasons will correspond to different prevention and control measures. We will enroll patients who are discharged after treatment, whose nucleic acid test has changed from negative to positive during the screening visit, regardless of the severity of the symptoms, to investigate the mechanism, clinical outcome and therapeutic efficacy with Favipiravir patients with Corona virus Disease 2019. Read More

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http://dx.doi.org/10.1186/s13063-020-04430-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273382PMC

Compartment syndrome of the leg after thyroid hormone withdrawal; two cases and a systematic review of the literature.

BMC Endocr Disord 2020 Jun 5;20(1):80. Epub 2020 Jun 5.

Department of Orthopedic and Trauma Surgery, Luzerner Kantonsspital Luzern, P.O. Box, Spitalstrasse, 6000, Lucerne, Switzerland.

Background: Acute compartment syndrome is a rare complication of severe hypothyroidism. If the symptoms are not recognized promptly and treatment initiated immediately, there is a high risk of permanent damage. Only few other cases of compartment syndrome due to hypothyroidism have been published and the exact pathophysiological mechanism remains unknown. Read More

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http://dx.doi.org/10.1186/s12902-020-00555-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275613PMC

Prediction of the recurrence risk in patients with epilepsy after the withdrawal of antiepileptic drugs.

Epilepsy Behav 2020 Jun 2;110:107156. Epub 2020 Jun 2.

Department of Neurology, First Affiliated Hospital of Kunming Medical University, 295 Xi Chang Road, Kunming, Yunnan 650032, PR China. Electronic address:

Many seizure-free patients who consider withdrawing from antiepileptic drugs (AEDs) hope to discontinue treatment to avoid adverse effects. However, withdrawal has certain risks that are difficult to predict. In this study, we performed a literature review, summarized the causes of significant variability in the risk of postwithdrawal recurrent seizures, and reviewed study data on the age at onset, cause, types of seizures, epilepsy syndrome, magnetic resonance imaging (MRI) abnormalities, epilepsy surgery, and withdrawal outcomes of patients with epilepsy. Read More

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http://dx.doi.org/10.1016/j.yebeh.2020.107156DOI Listing

Developmental Outcomes of Children Born with Neonatal Abstinence Syndrome (NAS): A Scoping Review.

Phys Occup Ther Pediatr 2020 Jun 4:1-14. Epub 2020 Jun 4.

School of Rehabilitation Therapy, Queen's University, Kingston, Ontario, Canada.

The purpose of this scoping review is to provide an overview of developmental outcomes of children diagnosed with neonatal abstinence syndrome (NAS). The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework was used to guide this scoping review. A comprehensive search of CINAHL, MEDLINE, EMBASE, Web of Science, and PsycINFO was conducted using search terms related to NAS and developmental areas. Read More

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http://dx.doi.org/10.1080/01942638.2020.1766637DOI Listing