Search Our Scientific Publications & Authors

Compr Psychoneuroendocrinol 2022 Aug 18;11:100143. Epub 2022 May 18.

AfaSci Research Laboratories, AfaSci Inc., Redwood City, CA, 94063, USA.

Prenatal exposure to drugs of abuse results in neonatal abstinence syndrome (NAS). NAS causes significant morbidity and is associated with costly and lengthy hospitalization. Current pharmacotherapy is suboptimal with no FDA approved treatments. Read More

Evid Based Complement Alternat Med 2022 15;2022:8547095. Epub 2022 Jun 15.

Department of Neurology, Guizhou Provincial People's Hospital, Guiyang, Guizhou 550002, China.

Objective: Guillain-Barré syndrome (GBS) is a common autoimmune disease of the peripheral nervous system, and there is still no effective treatment for GBS. This investigation intends to figure out the effect and mechanism of N-type voltage-gated calcium (Cav2.2) channels on neuropathic pain in GBS. Read More

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 May;47(5):583-587

Department of Nephrology, Second Xiangya Hospital, Central South University; Institute of Nephrology, Central South University, Changsha 410011, China.

We reported a case of oxalate crystal-related acute kidney injury caused by orlistat. The patient was admitted for nephrotic syndrome and acute kidney injury. The pathomorphological assessment of renal biopsy showed intratubular oxalate crystals. Read More

Medicina (Kaunas) 2022 May 30;58(6). Epub 2022 May 30.

Department of Ophthalmology, Centre Hospitalier Regional Universitaire de Tours, Bretonneau Hospital, 37000 Tours, France.

This article aims to describe a unique case of didanosine-induced retinal degeneration that was discovered 11 years after the drug withdrawal. The patient is a 42-year-old woman with a medical history of HIV and hepatitis C virus since 2004. She has been prescribed antiretroviral therapy since then. Read More

J Clin Med 2022 Jun 10;11(12). Epub 2022 Jun 10.

Critical Care, Hôpital d'Instruction des Armées Desgenettes, 69008 Lyon, France.

The management of sedation in the setting of COVID-19 ("COVID") by Ego et al. [.. Read More

In Vivo 2022 Jul-Aug;36(4):1994-1997

Nephrology, Dialysis and Kidney Transplantation Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy;

Background: Patients with autosomal dominant polycystic kidney disease (ADPKD) may require specific therapy with vasopressin receptor antagonists to slow the progression of renal disease. Because of its mechanism of action, the most common side effects are polyuria, nocturia, and polydipsia. Elevations of liver enzyme levels can also occur during treatment with Tolvaptan. Read More

Curr Res Toxicol 2022 6;3:100078. Epub 2022 Jun 6.

Kolling Institute of Medical Research, Royal North Shore Hospital of Sydney and Department of Medicine, University of Sydney, Sydney, NSW, Australia.

Respiratory depression (RD) is the primary cause of death due to opioids. Opioids bind to mu (µ)-opioid receptors (MORs) encoded by the MOR gene widely expressed in the central and peripheral nervous systems including centers that modulate breathing. Respiratory centers are located throughout the brainstem. Read More

Front Behav Neurosci 2022 6;16:855241. Epub 2022 Jun 6.

Department of Medical Pharmacology, Faculty of Medicine-Cerrahpasa, Istanbul University-Cerrahpasa, Istanbul, Turkey.

The underlying mechanism of dependence and rewarding effects of morphine is imperative to understand. The primary aim of this study was to investigate whether ropinirole D2/3 agonist affects the rewarding and reinforcing properties of morphine-induced conditioned place preference (CPP) and withdrawal syndromes in rats. On day one, the animals were randomly divided to conduct the pre-test. Read More

Sci Transl Med 2022 Jun 22;14(650):eabn8238. Epub 2022 Jun 22.

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.

Increased orexin/hypocretin signaling is implicated in opioid withdrawal, sleep disturbances, and drug-seeking behaviors. This study examined whether a dual-orexin receptor antagonist would improve sleep and withdrawal outcomes when compared with placebo during a buprenorphine/naloxone taper. Thirty-eight participants with opioid use disorder were recruited to a clinical research unit and maintained on 8/2 to 16/4 mg of buprenorphine/naloxone treatment for 3 days before being randomized to 20 mg of suvorexant ( = 14), 40 mg of suvorexant ( = 12), or placebo ( = 12); 26 individuals completed the study. Read More

Radiology 2022 Jul;304(1):241-244

From the Department of Radiology, University of Ottawa, 501 Smyth Rd, Ottawa, ON, Canada K1H 8L6 (N.R., O.H.A., C.H.T.), and Department of Medical Imaging, The Ottawa Hospital, Ottawa, Canada (O.H.A., C.H.T.).

History: A 54-year-old man was found by paramedics in his home face-down at his computer desk with a substantially reduced level of consciousness. He had not contacted his family for more than 50 hours. The patient lived alone and was a heavy smoker with a history of alcohol abuse. Read More

J Neuroendocrinol 2022 Jun 3. Epub 2022 Jun 3.

Department of Endocrinology, University Hospital Center Zagreb, Zagreb, Croatia.

After successful treatment for Cushing's syndrome (CS), secondary adrenal insufficiency develops as a result of the prior suppression of the hypothalamic-pituitary-adrenal (HPA) axis by excess cortisol in the body. Until the recovery of the HPA axis, glucocorticoid replacement therapy is required to enable normal functioning of the body and prevent adrenal crisis. Significant variation in the median time of recovery of the HPA axis is found in various cohorts of CS patients ranging from several weeks to years. Read More

Int J Soc Psychiatry 2022 Jun 20:207640221099408. Epub 2022 Jun 20.

Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Introduction: Hikikomori is a Japanese term etymologically derived from '' (i.e. '') and '' (i. Read More

Biomed Khim 2022 Jun;68(3):218-227

Serbsky National Medical Research Center for Psychiatry and Drug Addiction, Moscow, Russia.

Some BDNF (brain-derived neurotrophic factor)-targeted microRNAs such as miR-30a-5p associate with alcohol dependence phenomenon however their relationship with AWS is not described. We aimed to measure serum BDNF concentration and relative content of miR-30a-5p over the course of alcohol abstinence and compare obtained results with clinics of AWS. Additionally, we studied relative serum content of miR-30a-5p, a microRNA which does not target BDNF but relates to alcohol use disorder. Read More

Cell Mol Life Sci 2022 Jun 17;79(7):366. Epub 2022 Jun 17.

Groupe de Recherche Sur L'Alcool et Les Pharmacodépendances INSERM UMR1247, Centre Universitaire de Recherche en Santé CURS, Université de Picardie Jules Verne, Avenue Laennec, 80051, Amiens, France.

Alcohol-related liver disease is the most prevalent chronic liver disease worldwide, accounting for 30% of hepatocellular carcinoma (HCC) cases and HCC-specific deaths. However, the knowledge on mechanisms by which alcohol consumption leads to cancer progression and its aggressiveness is limited. Better understanding of the clinical features and the mechanisms of alcohol-induced HCC are of critical importance for prevention and the development of novel treatments. Read More

Endocr Metab Immune Disord Drug Targets 2022 Jun 16. Epub 2022 Jun 16.

Department of Endocrinology and Metabolism, Faculty of Medicine, Başkent University, Ankara, Turkey.

Backround: A considerable number of COVID-19 vaccines became available following the outbreak. Yet, various inflammatory and autoimmune complications have been reported following vaccination. We aimed to report the case of a type 1 diabetic patient converting from Hashimoto's thyroiditis to Graves' disease after the fourth dose of COVID-19 vaccine, thought to trigger an autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome). Read More

Ann Pharmacother 2022 Jun 17:10600280221102562. Epub 2022 Jun 17.

Department of Clinical Pharmacy, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, USA.

Background: Management of alcohol withdrawal syndrome (AWS) requires bedside assessments of symptom severity to guide therapies. Commonly used assessment tools are the Clinical Institute Withdrawal Assessment for Alcohol (CIWA-Ar), the modified Minnesota Detoxification Scale (mMINDS) and the Severity of Ethanol Withdrawal Scale (SEWS).

Objective: To determine strength of correlation between the CIWA-Ar, mMINDS, and SEWS for bedside assessment of severe AWS and to survey nurses regarding ease of use of each tool. Read More

Zhongguo Zhen Jiu 2022 Jun;42(6):654-62

Second Affiliated Hospital of Anhui University of CM, Hefei 230061; Anhui Acupuncture Clinical Medical Research Center, Hefei 230061; Clinical Institute of Acupuncture and Moxibustion, Anhui Academy of TCM, Hefei 230038.

Objective: To observe the effect of moxibustion on the regulation of nuclear factor-kappa B (NF-κB) and inflammatory factors by multiple microRNAs (miRNAs) in rats with diarrhea-predominant irritable bowel syndrome (IBS-D), and to explore the anti-inflammatory mechanism of moxibustion on IBS-D.

Methods: Twelve of 52 newborn rats were randomly selected into a normal group. The remaining rats were made into IBS-D model. Read More

Am J Perinatol 2022 Jun 16. Epub 2022 Jun 16.

Pediatrics, Saint Louis University School of Medicine, Saint Louis, United States.

Background: Infants with neonatal opioid withdrawal syndrome (NOWS) have disrupted neurobehavior that requires hospitalization and treatment.

Objective: To evaluate EEG abnormalities using amplitude integrated EEG (aEEG) in NOWS.

Design/methods: Eighteen term born infants with NOWS were recruited prospectively for an observational pilot study. Read More

BMC Pediatr 2022 Jun 15;22(1):345. Epub 2022 Jun 15.

Department of Family and Community Medicine, Department of Obstetrics, University of New Mexico, Albuquerque, NM, USA.

Background: Neonatal Opioid Withdrawal Syndrome (NOWS) is a significant public health issue and while millions of neonates are affected each year, an optimal pharmacologic weaning protocol has yet to be demonstrated. In this study, we compare hospital length of stay (LOS) and length of treatment (LOT) for treatment of neonatal opioid withdrawal (NOWS) with morphine versus methadone.

Methods: This was a single-site, open-label, randomized controlled pilot study conducted from October 2016-September 2018. Read More

Epidemiol Psychiatr Sci 2022 Jun 15;31:e43. Epub 2022 Jun 15.

Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.

Aims: The coronavirus disease 2019 (COVID-19) pandemic and ensuing restrictions have negatively affected the mental health and well-being of the general population, and there is increasing evidence suggesting that lockdowns have led to a disruption of health services. In March 2020, South Africa introduced a lockdown in response to the COVID-19 pandemic, entailing the suspension of all non-essential activities and a complete ban of tobacco and alcohol sales. We studied the effect of the lockdown on mental health care utilisation rates in private-sector care in South Africa. Read More

Ugeskr Laeger 2022 Jun;184(23)

Hormon- og knoglesygdomme, Aarhus Universitetshospital.

In this case report we describe a life-threatening episode of delirium in a 51-year-old man. The condition was triggered by an abrupt withdrawal of benzodiazepines. The patient had been taking multiple sedatives for several years but a large proportion of the drugs were not available in Denmark. Read More

J Clin Sleep Med 2022 Jun 11. Epub 2022 Jun 11.

Stanford University Center for Sleep Sciences and Medicine, Palo Alto, California.

Study Objectives: Evaluate long-term efficacy and safety of sodium oxybate (SXB) in children and adolescents (aged 7-16 years) with narcolepsy with cataplexy.

Methods: A double-blind randomized withdrawal study was conducted. Prior to randomization, SXB-naive participants were titrated to an efficacious and tolerable dose of SXB; participants taking SXB entered on their established dose. Read More

Drug Alcohol Depend 2022 May 30;237:109517. Epub 2022 May 30.

Division of Psychiatry, Medical School, the University of Western Australia, Australia; School of Medical and Health Sciences, Edith Cowan University, Australia; Fresh Start Recovery Programme, Subiaco, Western Australia, Australia.

Introduction: Benzodiazepines are commonly prescribed for a variety of indications and can be employed in the short- and long-term. While they are efficacious, issues arise from long-term use with the emergence of dependence and tolerance to doses within the therapeutic range and beyond. Discontinuation from benzodiazepines can be problematic for patients and may result in a withdrawal syndrome, which can be protracted and last months to years. Read More

J Psychopharmacol 2022 Jun 10:2698811221099645. Epub 2022 Jun 10.

Pharmacy Department, Maudsley Hospital, South London and Maudsley NHS Foundation Trust, London, UK.

Background: Intermittent (luteal phase) dosing of selective serotonin reuptake inhibitors is one treatment strategy for premenstrual syndromes such as premenstrual dysphoric disorder. This avoids the risk of the antidepressant withdrawal syndrome associated with long-term continuous dosing.

Aims: To compare intermittent dosing to continuous dosing in terms of efficacy and acceptability. Read More

Int J Environ Res Public Health 2022 06 5;19(11). Epub 2022 Jun 5.

Team MIMESIS, INRIA, UMR7357 CNRS, ICube Research Department, F-67085 Strasbourg, France.

In 2020, the World Health Organization formally recognized addiction to digital technology (connected devices) as a worldwide problem, where excessive online activity and internet use lead to inability to manage time, energy, and attention during daytime and produce disturbed sleep patterns or insomnia during nighttime. Recent studies have shown that the problem has increased in magnitude worldwide during the COVID-19 pandemic. The extent to which dysfunctional sleep is a consequence of altered motivation, memory function, mood, diet, and other lifestyle variables or results from excess of blue-light exposure when looking at digital device screens for long hours at day and night is one of many still unresolved questions. Read More

Expert Rev Hematol 2022 Jun 14:1-9. Epub 2022 Jun 14.

Department of Hematology/Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, South Korea.

Introduction: Myelofibrosis (MF) is characterized by ineffective and hepatosplenic extramedullary hematopoiesis due to fibrotic changes in the bone marrow and systemic manifestations due to aberrant cytokine release. Ruxolitinib (RUX) is the first JAK1/JAK2 inhibitor that is clinically approved to treat splenomegaly by ameliorating inflammatory cytokines and myeloproliferation in MF.

Areas Covered: Patients with less advanced MF may also achieve better outcome and successful treatment with RUX. Read More

World J Biol Psychiatry 2022 Jun 17:1-14. Epub 2022 Jun 17.

Zanjan Applied Pharmacology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.

Objectives: Methamphetamine (METH) as a potent psychostimulant drug with a high potency of dependence rate that results in neurotoxicity has become a major drug of abuse in many parts of the world. Unfortunately, there is limited evidence regarding treatment of METH withdrawal syndrome. Therefore, we aimed to investigate whether metformin mitigate the methamphetamine (METH) withdrawal syndrome in male mice. Read More

J Med Toxicol 2022 07 6;18(3):198-204. Epub 2022 Jun 6.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Advocate Christ Medical Center, 4440 West 95th Street, Oak Lawn, IL, 60453, USA.

Introduction: Phenobarbital is frequently used to manage severe alcohol withdrawal. The purpose of this study was to compare the incidence of mechanical ventilation in patients with benzodiazepine-resistant alcohol withdrawal between front-loaded and low-intermittent phenobarbital dosing strategies.

Methods: In this retrospective before-after study, we analyzed patients that received phenobarbital for severe alcohol withdrawal syndrome in a tertiary medical ICU. Read More

Cutis 2022 Mar;109(3):E29-E32

Department of Dermatology, Naval Medical Center, Camp Lejeune, North Carolina.

Angioimmunoblastic T-cell lymphoma (AITL) is a rare and aggressive lymphoma arising from follicular T-helper cells. Cutaneous findings and nonspecific systemic symptoms often associated with this malignancy can closely resemble those of more common entities, such as a viral exanthem or drug eruption, depending on the history and context. These similarities in presentation to more common entities can cause a delay in the diagnosis of AITL and subsequent initiation of treatment, which has considerable implications for morbidity and mortality. Read More

Hematol Transfus Cell Ther 2022 May 3. Epub 2022 May 3.

Complexo Hospital de Clínicas, Universidade Federal do Paraná (CHC-UFPR), Curitiba, PR, Brazil.

Introduction: Treatment-free remission (TFR) is a new goal of chronic myeloid leukemia (CML) therapy. TFR is feasible when the patient has achieved a deep and stable molecular response and met the criteria required to ensure its success. Treatment discontinuation should not be proposed to the CML patient if minimum conditions are not met. Read More