92,811 results match your criteria Withdrawal Syndromes


Sacubitril/valsartan in daily clinical practice: data from a prospective registry.

J Cardiovasc Pharmacol 2018 Dec 10. Epub 2018 Dec 10.

Servicio de Cardiología. Hospital Universitario Gregorio Marañón. CIBERCV. Madrid, Spain.

Sacubitril/valsartan (SV) is a new therapy in heart failure with reduced ejection fraction. Our aim was to determine the efficacy and safety of this drug daily clinical practice.We performed a multicenter registry in 10 hospitals. Read More

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December 2018
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Narcolepsy, Anesthesia, and Sedation: A Survey of the Perioperative Experience of Patients With Narcolepsy.

Anesth Analg 2018 Dec 11. Epub 2018 Dec 11.

Division of Pulmonary, Critical Care and Sleep Medicine, MetroHealth Medical Center, Cleveland, Ohio.

Background: Patients with narcolepsy may be at increased perioperative risk due to the interactions among anesthesia, narcolepsy, and narcolepsy medications. This study sought to determine the perioperative experience of narcoleptic patients undergoing anesthesia or sedation, the frequency of perioperative counseling, and self-reported surgical complications.

Methods: A 22-question survey was developed by expert consensus and distributed by the Narcolepsy Network. Read More

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December 2018

Symptomatic treatment of brain metastases in renal cell carcinoma with sorafenib.

J Cancer Res Ther 2018 Dec;14(Supplement):S1223-S1226

Department of Chemotherapy, Cancer Center, Qilu Hospital, Shandong University, Jinan 250012, China.

Brain metastasis is synchronous to the diagnosis of renal cell carcinoma (RCC). The prognosis of brain metastasis in RCC with the current treatment options is dismissal. Therefore, we present a case of an elderly female patient with RCC showing a partial response of brain metastasis after 18 months of 600 mg once daily sorafenib treatment who underwent right-sided nephrectomy. Read More

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December 2018

Narrative medicine applications for patient identity and quality of life in ventricular assist device (VAD) patients.

Heart Lung 2019 Jan 25;48(1):18-21. Epub 2018 Oct 25.

Gill Heart Institute, University of Kentucky, CTW 320, 900 S. Limestone Street, Lexington, KY, USA.

Patients with advanced heart failure may experience a variety of challenges to their self-identity and quality of life due to their heart condition and treatment by implantation of a ventricular assist device (VAD). These challenges include loss of energy and stamina, loss of independence and autonomy, dependence on loved ones and caregivers for help, strained relationships with family and friends, and uncertainty about treatment outcomes and time of recovery. Narrative Medicine (NM) sessions may help patients to reflect on their situation, rediscover identity, and engage sources of meaning by telling or writing their story. Read More

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January 2019

New therapeutic strategies in systemic lupus erythematosus management.

Nat Rev Rheumatol 2018 Dec 11. Epub 2018 Dec 11.

Unit of Rheumatology, Department of Medicine, University of Padova, Padova, Italy.

The current treatment approach for systemic lupus erythematosus (SLE), as outlined in the recommendations by international medical associations including EULAR and the ACR, is mostly eminence-based rather than evidence-based. However, knowledge on SLE is growing quickly, and such new advances need to be translated into clinical practice. Questions remain regarding the choice and timing of drug administration and tapering until withdrawal, which both can affect the balance between the control of disease activity and damage to organs triggered by long-standing and/or disproportionate immunosuppression. Read More

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December 2018

Continuous Langmuir-Blodgett deposition and transfer by controlled edge-to-edge assembly of floating 2D materials.

Langmuir 2018 Dec 12. Epub 2018 Dec 12.

The Langmuir-Blodgett technique is one of the most controlled methods to deposit monomolecular layers of floating or surface active materials but has lacked the ability to coat truly large area substrates. In this work, by manipulating single layer dispersions of graphene oxide (GO) and thermally exfoliated graphite oxide (TEGO) into water-immiscible spreading solvents, unlike traditional Langmuir-Blodgett deposition which requires densification achieved by compressing barriers, we demonstrate the ability to control the 2D aggregation and densification behavior of these floating materials using a barrier-free method. This is done by controlling the edge-to-edge interactions through modified sub-phase conditions and by utilizing the distance-dependent spreading pressure of the deposition solvent. Read More

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December 2018

Post-operative simultaneous very late two-vessel drug eluting stent thrombosis with sparing of bare metal stent in a Jehovah's witness after clopidogrel withdrawal.

J Cardiol Cases 2014 Feb 13;9(2):57-60. Epub 2013 Dec 13.

Department of Surgery/Anesthesiology, University of South Florida, Tampa, FL, USA.

Very late stent thrombosis is a feared complication after drug-eluting stent (DES) implantation. Several factors related to the patient, generation and type of the deployed stent, procedure, and premature antiplatelet withdrawal are known to contribute to this complication. Herein, we describe a case of a Jehovah's witness patient who developed simultaneous two-vessel 1st generation DES thrombosis 5. Read More

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February 2014

Prolonged hyponatremia due to hypopituitarism in a patient with non-ST-elevation myocardial infarction.

J Cardiol Cases 2014 Dec 30;10(6):226-230. Epub 2014 Aug 30.

Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

A 58-year-old man was admitted for non-ST-elevation myocardial infarction. A medicated stent was used for severe coronary artery stenosis. However, consciousness level progressively deteriorated after angioplasty. Read More

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December 2014

Myopericarditis in a pregnant woman with acute promyelocytic leukemia.

J Cardiol Cases 2014 Nov 19;10(5):200-203. Epub 2014 Aug 19.

OHSU Knight Cardiovascular Institute, Portland, OR, USA.

Acute promyelocytic leukemia (APL) is a form of acute leukemia with a characteristic translocation, t(15;17), and is considered a hematologic emergency, typically treated with all-trans retinoic acid and an anthracycline. We present the case of a young, gravid woman who was diagnosed with APL in the third trimester, initiated typical treatment, and suffered uncommon cardiac complications. < Myopericarditis is not a side effect often encountered in the management of acute promyelocytic leukemia with alpha t-retinoic acid, and its mechanism is incompletely understood but possibly related to the differentiation syndrome. Read More

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November 2014

Late in-stent restenosis after sirolimus-eluting stent implantation is related to thrombus formation-Insight from a case with IVUS, OCT, and histological findings.

J Cardiol Cases 2012 Apr 17;5(2):e83-e86. Epub 2012 Mar 17.

Division of Cardiology, Nagoya City East Medical Center, Nagoya, Japan.

We experienced a case of very late in-stent restenosis of a sirolimus-eluting stent (SES) (3.0 mm × 18 mm) in the left anterior descending coronary artery in a 62-year-old man with type 2 diabetes mellitus, dyslipidemia, and hypertension. Angina pectoris recurred 39 months after the index percutaneous coronary intervention (PCI). Read More

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Elevated resting blood pressure augments autonomic imbalance in posttraumatic stress disorder.

Am J Physiol Regul Integr Comp Physiol 2018 Dec 10;315(6):R1272-R1280. Epub 2018 Oct 10.

Renal Division, Department of Medicine, Emory University School of Medicine , Atlanta, Georgia.

Posttraumatic stress disorder (PTSD) is characterized by increased sympathetic nervous system (SNS) activity, blunted parasympathetic nervous system (PNS) activity, and impaired baroreflex sensitivity (BRS), which contribute to accelerated cardiovascular disease. Patients with PTSD also have chronic stress-related elevations in resting blood pressure (BP), often in the prehypertensive range; yet, it is unclear if elevated resting blood pressure (ERBP) augments these autonomic derangements in PTSD. We hypothesized that compared with normotensive PTSD (N-PTSD), those with ERBP (E-PTSD) have further increased SNS, decreased PNS activity, and impaired BRS at rest and exaggerated SNS reactivity, PNS withdrawal, and pressor responses during stress. Read More

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December 2018

Brain glutamate, GABA, and glutamine levels and associations with recent drinking in treatment-naïve individuals with Alcohol Use Disorder versus light drinkers.

Alcohol Clin Exp Res 2018 Dec 10. Epub 2018 Dec 10.

Department of Psychiatry and Behavioral Sciences.

Background: Proton Magnetic Resonance Spectroscopy ( H-MRS) studies have demonstrated abnormal levels of a variety of neurometabolites in inpatients/outpatients with Alcohol Use Disorder (AUD) following acute alcohol withdrawal relative to healthy controls. In contrast, few studies have compared neurometabolite levels between less severe, treatment-naïve AUD individuals and light drinkers or related them to recent alcohol consumption. The present study compared neurometabolite levels between treatment-naïve AUD and LD individuals. Read More

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December 2018

Better Biomarkers for Lupus Disease Activity - Tools for Treating to Target.

Authors:
Susan A Boackle

Arthritis Rheumatol 2018 Dec 7. Epub 2018 Dec 7.

Division of Rheumatology, University of Colorado Denver School of Medicine, Aurora, CO.

Sometimes new ideas come from old places. Complement's central role in lupus pathogenesis has been known for years, and a reduction in C3 and C4 levels is one of the strongest biomarkers for increased lupus disease activity. However, every rheumatologist knows that some patients with no symptoms of active lupus will present with low complement levels, whereas some patients with aggressive disease have levels that never budge from the "normal" range. Read More

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December 2018

The Fyn kinase inhibitor, AZD0530, suppresses mouse alcohol self-administration and seeking.

Addict Biol 2018 Dec 7. Epub 2018 Dec 7.

Department of Neurology, University of California San Francisco, San Francisco, California.

Fyn is a member of the Src family of protein tyrosine kinases (PTKs) that plays an important role not only in normal synaptic functions but also in brain pathologies including alcohol use disorder. We previously reported that repeated cycles of binge drinking and withdrawal activate Fyn in the dorsomedial striatum (DMS) of rodents, and that Fyn signaling in the DMS contributes to rat alcohol intake and relapse. Here, we used AZD0530, a CNS penetrable inhibitor of Src PTKs developed for the treatment of Alzheimer disease and cancer and tested its efficacy to suppress alcohol-dependent molecular and behavioral effects. Read More

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December 2018

Heart transplantation in two adolescents with Danon disease.

Pediatr Transplant 2018 Dec 7:e13335. Epub 2018 Dec 7.

Department of Pediatrics (Cardiology), Stanford University Medical Center, Stanford University, Stanford, California.

Danon disease (DD) is an X-linked dominant disorder caused by a mutation in the lysosomal-associated membrane protein-2 (LAMP-2) gene coding for the LAMP-2 protein. We report two cases of successful heart transplantation (HT) in adolescent brothers with DD, including one who was bridged to HT for 34 days with a HeartWare left ventricular assist device. In both patients, the post-transplant course was complicated by profound skeletal muscle weakness that resolved with corticosteroid withdrawal. Read More

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December 2018

Withholding and withdrawing treatment for cost-effectiveness reasons: Are they ethically on par?

Bioethics 2018 Dec 7. Epub 2018 Dec 7.

Linkopings universitet, Linkoping, Sweden.

In healthcare priority settings, early access to treatment before reimbursement decisions gives rise to problems of whether negative decisions for cost-effectiveness reasons should result in withdrawing treatment, already accessed by patients. Among professionals there seems to be a strong attitude to distinguish between withdrawing and withholding treatment, viewing the former as ethically worse. In this article the distinction between withdrawing and withholding treatment for reasons of cost effectiveness is explored by analysing the doing/allowing distinction, different theories of justice, consequentialist and virtue perspectives. Read More

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December 2018

Changes in Body Adiposity, Dietary Intake, Physical Activity and Quality of Life of Obese Individuals Submitted to Intragastric Balloon Therapy for 6 Months.

Obes Surg 2018 Dec 7. Epub 2018 Dec 7.

Department of Applied Nutrition, Nutrition Institute, Rio de Janeiro State University, 12th floor/524, São Francisco Xavier Street, Rio de Janeiro, RJ, 20550-900, Brazil.

Background: Obesity is an important risk factor for several chronic diseases and also is associated with worse quality of life. Intragastric balloon (IGB) is an effective method for weight loss. Although changes in lifestyle are critical to weight loss during and after IGB therapy, only a few studies evaluated dietary intake and none evaluated changes in physical activity with a validated questionnaire during the treatment. Read More

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December 2018

Therapy of Advanced Prostate Cancer: Targeting the Androgen Receptor Axis in Earlier Lines of Treatment.

Target Oncol 2018 Dec 7. Epub 2018 Dec 7.

Department of Oncology, Wayne State University/Karmanos Cancer Institute, 4100 John R, Detroit, MI, 48201, USA.

With the decrease in PSA screening based on the 2011 United States Preventive Services Task Force guidelines and the potential approval of highly sensitive imaging techniques over the next few years, we are likely to see an increasing trend of metastatic prostate cancer diagnosis. Traditional therapy for nonmetastatic prostate cancer (nmPC) has consisted of androgen deprivation therapy (ADT) followed by other hormonal therapy maneuvers, such as anti-androgen withdrawal, herbal preparations, low dose steroids, or ketoconazole. Androgen receptor-axis-targeted therapies (ARAT) were previously only approved for patients with metastatic castration resistant prostate cancer (mCRPC). Read More

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December 2018

Approaches to Deprescribing Psychotropic Medications for Changed Behaviours in Long-Term Care Residents Living with Dementia.

Drugs Aging 2018 Dec 11. Epub 2018 Dec 11.

Dementia Centre for Research Collaboration, School of Psychiatry, UNSW Sydney, Sydney, NSW, Australia.

Psychotropic medications have a high risk of serious adverse events and small effect size for changed behaviours for people with dementia. Non-pharmacological approaches are recommended as first-line treatment for changed behaviours, yet psychotropic medications remain highly prevalent in long-term aged care settings. This narrative review describes the current evidence regarding deprescribing psychotropic medications for people with dementia in long-term care. Read More

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December 2018

Selective adrenergic alpha2C receptor antagonist ameliorates acute phencyclidine-induced schizophrenia-like social interaction deficits in rats.

Psychopharmacology (Berl) 2018 Dec 10. Epub 2018 Dec 10.

School of Pharmacy, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland.

Rationale: Social withdrawal is a core feature of the negative symptoms of schizophrenia. Currently available pharmacotherapies have only limited efficacy towards the negative symptoms, i.e. Read More

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December 2018

Early extubation followed by immediate noninvasive ventilation vs. standard extubation in hypoxemic patients: a randomized clinical trial.

Intensive Care Med 2018 Dec 10. Epub 2018 Dec 10.

Anestesia e Rianimazione, Dipartimento di Scienze Mediche e Chirurgiche, Università "Magna Graecia", Viale Europa (Loc. Germaneto), Catanzaro, Italy.

Purpose: Noninvasive ventilation (NIV) may facilitate withdrawal of invasive mechanical ventilation (i-MV) and shorten intensive care unit (ICU) length of stay (LOS) in hypercapnic patients, while data are lacking on hypoxemic patients. We aim to determine whether NIV after early extubation reduces the duration of i-MV and ICU LOS in patients recovering from hypoxemic acute respiratory failure.

Methods: Highly selected non-hypercapnic hypoxemic patients were randomly assigned to receive NIV after early or standard extubation. Read More

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December 2018

Withdrawal Symptom, Treatment Mechanism, and/or Side Effect? Developing an Explicit Measurement Model for Smoking Cessation Research.

Nicotine Tob Res 2018 Dec 11. Epub 2018 Dec 11.

University at Buffalo, The State University of New York.

Introduction: Assessment of withdrawal symptoms, treatment mechanisms, and side effects is central to understanding and improving smoking cessation interventions. Though each domain is typically assessed separately with widely-used questionnaires to separately assess each domain (e.g. Read More

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December 2018
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Primary Motor Cortex Transcranial Direct Current Stimulation Modulates Temporal Summation of the Nociceptive Withdrawal Reflex in Healthy Subjects.

Pain Med 2018 Dec 7. Epub 2018 Dec 7.

The Nick Davey Laboratory, Faculty of Medicine, Imperial College London, London, UK.

Objective: Transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) has shown efficacy in a number of chronic pain conditions. Despite attempts to dissect the analgesic mechanisms, it is unknown whether M1 tDCS modulates the central integration of spinal nociception. To test this, we investigated the top-down modulation of spinal excitability using temporal summation (TS) of the nociceptive withdrawal reflex (NWR). Read More

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December 2018

Non-battle Emergency Department Utilization of the First Modular Army Field Hospital Prototype in Support of Operation INHERENT RESOLVE.

Mil Med 2018 Dec 7. Epub 2018 Dec 7.

San Antonio Military Medical Center, 3551 Roger Brooke Drive, Joint Base San Antonio, TX.

Introduction: The 2010-2011 withdrawal from Iraq included the closure of all fixed-facility military medical resources. Operation INHERENT RESOLVE, the United States-led counter-terrorism mission in Iraq and Syria, subsequently commenced in 2014. With increasing combat operations, the 28th Combat Support Hospital deployed to Iraq to support that mission as a limited footprint unit prototyped after the new modular Army Field Hospital. Read More

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December 2018

[Remarks on the possibility of the introduction of fractionated dose of the inactivated poliomyelitis vaccine in the Latin American Child Immunization Schedule].

Rev Chilena Infectol 2018 Aug;35(4):395-402

Sociedad Latinoamericana de Infectología Pediátrica, Mexico.

As last notified case of poliomyelitis due to wild poliovirus type 2 was 1999, in 2012, the Strategic Advisory Group of Experts on Immunization (SAGE) of the World Health Organization (WHO) recommended the withdrawal of the type 2 component of oral polio vaccine (OPV) and the introduction of bivalent OPV (bOPV) in all countries by 2016. WHO recommended also that the withdrawal should be preceded by the introduction of at least one dose of inactivated poliovirus vaccine (IPV) in routine immunization schedules. The introduction of IPV prior to the change of the bOPV in 2016 to trivalent OPV (tOPV) was based on the concept of ensuring that a substantial proportion of the population would be protected against type 2 polio after the removal of the type 2 OPV. Read More

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The Effectiveness of Hepatic Arterial Infusion Chemotherapy with 5-Fluorouracil/Cisplatin and Systemic Chemotherapy with Ramucirumab in Alpha-Fetoprotein-Producing Gastric Cancer with Multiple Liver Metastases.

Case Rep Oncol Med 2018 11;2018:5402313. Epub 2018 Nov 11.

Department of Pathology, Kurume University Hospital, Kurume, Japan.

Alpha-fetoprotein- (AFP-) producing gastric cancer (AFPGC) is characterized by a high incidence of liver and lymph node metastases and poor prognosis. Although several case reports have described successful multidisciplinary treatment, there are currently no standard therapies for AFPGC. A 57-year-old man presented with upper abdominal pain. Read More

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November 2018
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Electroacupuncture Treatment Alleviates the Remifentanil-Induced Hyperalgesia by Regulating the Activities of the Ventral Posterior Lateral Nucleus of the Thalamus Neurons in Rats.

Neural Plast 2018 11;2018:6109723. Epub 2018 Nov 11.

Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100083, China.

Mechanisms underlying remifentanil- (RF-) induced hyperalgesia, a phenomenon that is generally named as opioid-induced hyperalgesia (OIH), still remain elusive. The ventral posterior lateral nucleus (VPL) of the thalamus, a key relay station for the transmission of nociceptive information to the cerebral cortex, is activated by RF infusion. Electroacupuncture (EA) is an effective method for the treatment of pain. Read More

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November 2018

Decreased Blood Levels of Oxytocin in Ketamine-Dependent Patients During Early Abstinence.

Front Psychiatry 2018 26;9:633. Epub 2018 Nov 26.

Department of Psychiatry, Yale University School of Medicine, New Heaven, CT, United States.

Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, is a common drug of abuse worldwide. Existing evidence suggest a disruption of oxytocin system involves in the development of addiction. In this study, we aimed to investigate the role of oxytocin in ketamine addiction by measuring the blood oxytocin levels in ketamine-dependent (KD) patients. Read More

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November 2018

The Role of professional facilitators in cross-border assisted reproduction.

Authors:
Jenni Millbank

Reprod Biomed Soc Online 2018 Aug 9;6:60-71. Epub 2018 Nov 9.

University of Technology Sydney, PO Box 123 Broadway, NSW 2007, Australia.

The operations of those who facilitate travel across international borders for access to assisted reproduction are little understood. Within the broader field of research into medical travel facilitators, most empirical studies have addressed websites and promotional materials, with few qualitative investigations of individuals who are service providers. The research presented here centres on interviews with 23 professionals facilitating cross-border assisted reproduction. Read More

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Regional Cerebral Oximetry as an Indicator of Acute Brain Injury in Adults Undergoing Veno-Arterial Extracorporeal Membrane Oxygenation-A Prospective Pilot Study.

Front Neurol 2018 23;9:993. Epub 2018 Nov 23.

Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD, United States.

Regional cerebral oxygen saturation (rScO2) measured by near-infrared spectroscopy (NIRS) can be used to monitor brain oxygenation in extracorporeal membrane oxygenation (ECMO). ECMO patients that develop acute brain injuries (ABIs) are observed to have worse outcomes. We evaluated the association between rScO2 and ABI in venoarterial (VA) ECMO patients. Read More

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November 2018

Intra-Articular Injection of Extract Attenuates Pain Behavior and Cartilage Degeneration in Mono-Iodoacetate Induced Osteoarthritic Rats.

Front Pharmacol 2018 23;9:1360. Epub 2018 Nov 23.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany.

(FLL) has been widely used as a traditional Chinese medicine (TCM) for treating soreness and weakness of waist and knees. It has potential for treating OA owing to its kidney-tonifying activity with bone-strengthening effects, but there is so far no report of its anti-OA effect. This study established a rat OA model by intra-articular (IA) injection of mono-iodoacetate (1. Read More

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November 2018

Identifying the pathways required for coping behaviours associated with sustained pain.

Nature 2018 Dec 10. Epub 2018 Dec 10.

Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

Animals and humans display two types of response to noxious stimuli. The first includes reflexive defensive responses that prevent or limit injury; a well-known example of these responses is the quick withdrawal of one's hand upon touching a hot object. When the first-line response fails to prevent tissue damage (for example, a finger is burnt), the resulting pain invokes a second-line coping response-such as licking the injured area to soothe suffering. Read More

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December 2018
4 Reads

Buprenorphine Pharmacology Review: Update on Transmucosal and Long-acting Formulations.

J Addict Med 2018 Oct 23. Epub 2018 Oct 23.

Department of Pharmacology, College of Medicine, University of Kentucky, Lexington, KY (MAC, SLW); Department of Behavioral Science, University of Kentucky, Lexington, KY (MRL, SLW); and Center on Drug and Alcohol Research, University of Kentucky, Lexington, KY (MAC, MRL, SLW).

: Buprenorphine is an effective treatment for opioid use disorder. As a high-affinity, partial agonist for the mu-opioid receptor, buprenorphine suppresses opioid withdrawal and craving, reduces illicit opioid use, and blocks exogenous opioid effects including respiratory depression. Other pharmacologic benefits of buprenorphine are its superior safety profile compared with full opioid agonists and its long half-life that allows daily or less-than-daily dosing. Read More

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October 2018
3 Reads

Safety and Efficacy of Lofexidine for Medically Managed Opioid Withdrawal: A Randomized Controlled Clinical Trial.

J Addict Med 2018 Nov 29. Epub 2018 Nov 29.

Department of Psychiatry, Johns Hopkins School of Medicine and Maryland Treatment Centers, Baltimore, MD (MF); CARMA Health, PLLC, Austin, TX (CT); Northwestern Medicine Central DuPage Hospital, Winfield, IL (DA); Pharmaceutical Development and Regulatory Affairs, US WorldMeds, LLC, Louisville, KY (KG); Biometrics, US WorldMeds, LLC, Louisville, KY (TC); Consultant to US WorldMeds, LLC, Louisville, KY (CWG).

Objectives: To investigate the safety and efficacy of lofexidine for treating opioid withdrawal syndrome (OWS) and facilitating completion of opioid withdrawal.

Methods: A multicenter, double-blind, placebo-controlled study was conducted at 18 US centers from June 2013 to December 2014. Participants (n = 603) aged ≥18 years, dependent on short-acting opioids, and seeking withdrawal treatment, randomized 3:3:2 to receive lofexidine 2. Read More

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November 2018

Lofexidine for Opioid Withdrawal: Small Effects at an Exorbitant Price.

Authors:
David N Juurlink

J Addict Med 2018 Nov 29. Epub 2018 Nov 29.

Divisions of General Internal Medicine and Clinical Pharmacology & Toxicology, Department of Medicine, Sunnybrook Health Sciences Centre, and the University of Toronto, Toronto, Ontario, Canada.

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November 2018

[Successful treatment of post-allogeneic hematopoietic transplant immune thrombocytopenia with eltrombopag].

Rinsho Ketsueki 2018 ;59(11):2418-2422

Department of Hematology and Immunology, Otsu Red Cross Hospital.

A 44-year-old woman in the first remission phase of mixed-phenotype acute leukemia (T-lymphoid and myeloid lineages) suddenly exhibited thrombocytopenia (1.1×10/µl) with generalized petechiae approximately 150 days after bone marrow transplantation (BMT) from a one-locus (HLA-B) mismatched unrelated donor. Until then, the donor bone marrow had smoothly engrafted, and the platelet count had promptly normalized. Read More

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January 2018

Computer-Aided Telephone Support for Primary Care Patients with Common Mental Health Conditions: Randomized Controlled Trial.

JMIR Ment Health 2018 Dec 10;5(4):e10224. Epub 2018 Dec 10.

Centre for Addiction and Mental Health, Toronto, ON, Canada.

Background: Depression, anxiety, and at-risk drinking are highly prevalent in primary care settings. Many jurisdictions experience geographical barriers to accessing mental health services, necessitating the development and validation of alternative models of care delivery. Existing evidence supports the acceptability and effectiveness of providing mental health care by telephone. Read More

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December 2018

KCNQ2 mutation in an infant with encephalopathy of infancy with migrating focal seizures.

Epileptic Disord 2018 Dec 10. Epub 2018 Dec 10.

Department of Pediatrics (Neurology), McMaster University, 1280 Main St., W. Hamilton, Ontario L8S 4K1, Canada.

A male neonate presented with seizures at 18 hours of life, characterized by tonic posturing with eye deviation to the right, apnoea, bradycardia, and oxygen desaturation. Initial structural, metabolic, and infectious work-up was unremarkable. He continued to have seizures refractory to a variety of antiepileptic medications. Read More

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December 2018

Systematic review of outcome domains and measures used in psychosocial and pharmacological treatment trials for cannabis use disorder.

Drug Alcohol Depend 2018 Nov 15;194:500-517. Epub 2018 Nov 15.

Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Cannabis use disorder (CUD) is prevalent and demand for treatment is increasing, yet few individuals engage in formal treatment and the efficacy of established interventions for CUD is modest. Existing clinical trials evaluating psychosocial and pharmacological treatments for CUD have incorporated a wide variety of measures for assessing cannabis use outcomes, including abstinence, self-reported frequency and quantity used, withdrawal, use/dependence severity, and other psychosocial outcomes. The heterogeneity of measures and outcomes has limited quantitative analyses of the comparative effectiveness of existing interventions. Read More

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November 2018
1 Read

Tropomyosin receptor kinase B receptor activation in the locus coeruleus restores impairment of endogenous analgesia at a late stage following nerve injury in rats.

J Pain 2018 Dec 7. Epub 2018 Dec 7.

Department of Anesthesiology, Gunma University Graduate School of Medicine, (3-39-22 Showa, Maebashi, Gunma 371-8511, Japan).

A rat model of neuropathic pain at 6 weeks after spinal nerve ligation (SNL6w) exhibits both mechanical hypersensitivity and impaired noxious stimuli-induced analgesia (NSIA). Repeated treatment with antidepressants can produce anti-hypersensitivity and restore NSIA. To examine the involvement of a brain-derived neurotrophic factor-mediated mechanism, a tropomyosin receptor kinase B (TrkB) agonist, 7,8-dihydroxyflavone (DHF), was administered to SNL6w rats (5 mg• kg• day, 5 days). Read More

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December 2018

Agkistrodon ameliorates pain response and prevents cartilage degradation in monosodium iodoacetate-induced osteoarthritic rats by inhibiting chondrocyte hypertrophy and apoptosis.

J Ethnopharmacol 2018 Dec 5. Epub 2018 Dec 5.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany.

Ethnopharmacological Relevance: Osteoarthritis (OA), characterized by joint pain and cartilage degradation, is the most common form of joint disease worldwide but with no satisfactory therapy available. The ethanol extract of Agkistrodon acutus (EAA) has been widely used as a traditional Chinese medicine (TCM) for the treatment of arthralgia and inflammatory diseases, but there is no report regarding its efficacy on OA to date. Here, we determined the effects of EAA on the pain behavior and cartilage degradation in vivo and clarified its target genes and proteins associated with chondrocyte hypertrophy and apoptosis in vitro. Read More

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December 2018

Mechanistic insights of hepatoprotective effects of curcumin: Therapeutic updates and future prospects.

Food Chem Toxicol 2018 Dec 5. Epub 2018 Dec 5.

Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

The liver is the most essential organ of the body performing vital functions. Hepatic disorders affect the physiological and biochemical functions of the body. These disorders include hepatitis B, hepatitis C, alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD), liver cirrhosis, hepatic failure and hepatocellular carcinoma (HCC). Read More

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December 2018

DID it or DIDn't it? Exploration of a failure to replicate binge-like alcohol-drinking in C57BL/6J mice.

Pharmacol Biochem Behav 2018 Dec 7. Epub 2018 Dec 7.

Department of Psychological and Brain Sciences, University of California at Santa Barbara, Santa Barbara, CA, USA; Department of Molecular, Developmental and Cell Biology and the Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, CA, USA; Institute for Collaborative Biotechnology, University of California at Santa Barbara, Santa Barbara, CA, USA.

We previously reported that commercially-sourced C57BL/6J (B6) male mice with a history of adult-onset binge-drinking exhibit anxiety-like behavior in early withdrawal, while the negative affective state incubates during protracted withdrawal in adolescent-onset binge-drinking males. As the results of such studies are potentially confounded by age-related differences in reactivity to environmental stress, we employed a 2-bottle-choice DID procedure (20 and 40% alcohol; 20 min habituation to the drinking cage) to examine the effects of binge-drinking on negative affect in male and female, adult and adolescent, B6 mice from our university colony. Unexpectedly, the mice in the initial experiment exhibited very low alcohol intake, with little sign of withdrawal-induced negative affect. Read More

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December 2018

Role of nitric oxide in the induction of the behavioral and cellular changes produced by a common aversive stimulus in Aplysia.

Behav Brain Res 2018 Dec 6. Epub 2018 Dec 6.

Department of Life Sciences, Texas A&M University - Corpus Christi, 6300 Ocean Drive, Unit 5800, Corpus Christi, TX, 78412, USA. Electronic address:

Although it is well documented that exposure to aversive stimuli induces modulation of neural circuits and subsequent behavioral changes, the means by which an aversive stimulus concomitantly alters behaviors of different natures (e.g., defensive and appetitive) remains unclear. Read More

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December 2018

Efficacy and safety of a fatty acid amide hydrolase inhibitor (PF-04457845) in the treatment of cannabis withdrawal and dependence in men: a double-blind, placebo-controlled, parallel group, phase 2a single-site randomised controlled trial.

Lancet Psychiatry 2018 Dec 6. Epub 2018 Dec 6.

Schizophrenia and Neuropharmacology Research Group, VA Connecticut Healthcare System, West Haven, CT, USA; Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, CT, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

Background: Cannabis is one of the most widely used drugs worldwide. Cannabis use disorder is characterised by recurrent use of cannabis that causes significant clinical and functional impairment. There are no approved pharmacological treatments for cannabis use disorder. Read More

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December 2018
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Medetomidine-ketamine-sevoflurane anaesthesia in juvenile Nile crocodiles (Crocodylus niloticus) undergoing experimental surgery.

Vet Anaesth Analg 2018 Sep 19. Epub 2018 Sep 19.

Department of Clinical Sciences and Services, The Royal Veterinary College, Hatfield, UK. Electronic address:

Objective: To describe the anaesthetic, physiological and side effects of intramuscular (IM) medetomidine and ketamine, followed by inhalational anaesthesia with sevoflurane, in Nile crocodiles (Crocodylus niloticus).

Study Design: Observational trial.

Animals: Ten juvenile captive-bred Nile crocodiles undergoing surgical implantation of skeletal beads and muscular electrodes. Read More

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September 2018

Sedation Management for Critically Ill Children with Pre-Existing Cognitive Impairment.

J Pediatr 2018 Dec 5. Epub 2018 Dec 5.

The Research Institute, Children's Hospital of Philadelphia, Philadelphia, PA; Department of Family and Community Health, School of Nursing, Department of Anesthesia and Critical Care Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Electronic address:

Objective: To compare current analgesia and sedation management practices between critically ill children with pre-existing cognitive impairment and critically ill neurotypical children, including possible indicators of therapeutic efficacy.

Study Design: This study used secondary analysis of prospective data from the RESTORE clinical trial, with 2449 children admitted to the pediatric intensive care unit and receiving mechanical ventilation for acute respiratory failure. Subjects with a baseline Pediatric Cerebral Performance Category ≥3 were defined as subjects with cognitive impairment, and differences between groups were explored using regression methods accounting for pediatric intensive care unit as a cluster variable. Read More

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December 2018

Single high-dose buprenorphine for opioid craving during withdrawal.

Trials 2018 Dec 10;19(1):675. Epub 2018 Dec 10.

Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, California, USA.

Background: Opioid use disorder is one of the most prevalent addiction problems worldwide. Buprenorphine is used as a medication to treat this disorder, but in countries where buprenorphine is unavailable in combination with naloxone, diversion can be a problem if the medication is given outside a hospital setting.

Objective: The objective of this research is to evaluate the effect of a single, high dose of buprenorphine on craving in opioid-dependent patients over 5 days of abstinence from use of other opioids. Read More

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December 2018
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RETRACTED ARTICLE:.Notice of Withdrawal.

Authors:

Environ Technol 2018 Dec 10. Epub 2018 Dec 10.

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December 2018