Identification of drug-target interaction from interactome network with 'guilt-by-association' principle and topology features.
- Zhan-Chao Li,
- Meng-Hua Huang,
- Wen-Qian Zhong,
- Zhi-Qing Liu,
- Yun Xie,
- Zong Dai,
- Xiao-Yong Zou
Bioinformatics 2016 Apr 26;32(7):1057-64. Epub 2015 Nov 26.
SYSU-CMU Shunde International Joint Research Institute, Shunde 528300, People's Republic of China and School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, People's Republic of China.
Motivation: Identifying drug-target protein interaction is a crucial step in the process of drug research and development. Wet-lab experiment are laborious, time-consuming and expensive. Hence, there is a strong demand for the development of a novel theoretical method to identify potential interaction between drug and target protein. Read More