12,414 results match your criteria Wilms Tumor


Pre-existing fibroblasts of epicardial origin are the primary source of pathological fibrosis in cardiac ischemia and aging.

J Mol Cell Cardiol 2019 Feb 13. Epub 2019 Feb 13.

Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA; Department of Biomedical Engineering, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA; Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA; Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA. Electronic address:

Serum response factor (SRF) and the SRF co-activators myocardin-related transcription factors (MRTFs) are essential for epicardium-derived progenitor cell (EPDC)-mobilization during heart development; however, the impact of developmental EPDC deficiencies on adult cardiac physiology has not been evaluated. Here, we utilize the Wilms Tumor-1 (Wt1)-Cre to delete Mrtfs or Srf in the epicardium, which reduced the number of EPDCs in the adult cardiac interstitium. Deficiencies in Wt1-lineage EPDCs prevented the development of cardiac fibrosis and diastolic dysfunction in aged mice. Read More

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http://dx.doi.org/10.1016/j.yjmcc.2019.01.015DOI Listing
February 2019

The Pediatric Surgical Team: a Model for Increased Surgeon Index Case Exposure.

J Pediatr Surg 2019 Jan 21. Epub 2019 Jan 21.

Kapi'olani Medical Center for Children, 1319 Punahou St., Honolulu, HI, USA 96826.

Background/purpose: High surgical volume for both surgeons and hospital systems has been linked to improved outcomes for many surgical problems, yet case volumes per pediatric surgeon are diminishing nationally in complex pediatric surgery. We therefore sought to review our experience in a geographically isolated setting where a surgical team approach has been used to improve per-surgeon exposure to index pediatric surgical cases.

Methods: As a surgical group, we incorporated a surgical team approach to complex pediatric surgical cases in 2010. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2018.12.018DOI Listing
January 2019

The Wilms' tumor suppressor gene regulates pancreas homeostasis and repair.

PLoS Genet 2019 Feb 14;15(2):e1007971. Epub 2019 Feb 14.

Department of Animal Biology, Faculty of Science, University of Málaga, Málaga, Spain.

The Wilms' tumor suppressor gene (Wt1) encodes a zinc finger transcription factor that plays an essential role in the development of kidneys, gonads, spleen, adrenals and heart. Recent findings suggest that WT1 could also be playing physiological roles in adults. Systemic deletion of WT1 in mice provokes a severe deterioration of the exocrine pancreas, with mesothelial disruption, E-cadherin downregulation, disorganization of acinar architecture and accumulation of ascitic transudate. Read More

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http://dx.doi.org/10.1371/journal.pgen.1007971DOI Listing
February 2019

The diagnostic accuracy and clinical utility of pediatric renal tumor biopsy: Report of the UK experience in the SIOP UK WT 2001 trial.

Pediatr Blood Cancer 2019 Feb 13:e27627. Epub 2019 Feb 13.

Department of Cellular Pathology, University Hospital of Wales, Cardiff, UK.

Introduction: The International Society of Paediatric Oncology (SIOP) protocols recommend preoperative chemotherapy appropriate for Wilms tumors (WTs) in children with renal tumors aged ≥6 months, reserving biopsy for "atypical" cases. The Children's Cancer and Leukaemia Group (CCLG) joined the SIOP-WT-2001 study but continued the national practice of biopsy at presentation.

Method: Retrospective study of concordance between locally reported renal tumor biopsies and central pathology review nephrectomy diagnoses of children enrolled by CCLG centers in the SIOP-WT-2001 study. Read More

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http://dx.doi.org/10.1002/pbc.27627DOI Listing
February 2019
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Delayed IL-21 treatment preferentially expands peptide-specific CD8 T cells by reducing bystander activation of T cells.

Immunotherapy 2019 Feb 14. Epub 2019 Feb 14.

Biomedicine Production Branch, National Cancer Center, Goyang, 10408 Korea.

Aim: We previously reported a simple and practical procedure to generate peptide-specific CD8 T cells using peptide and IL-2, which is applied to produce human telomerase reverse transcriptase (hTERT)-specific CD8+ T cells for clinical use. We have modified the procedure to enhance the amplification of peptide-specific CD8 T cells adding IL-21.

Materials & Methods: Using human leukocyte antigen (HLA)-A*0201-restricted cytomegalovirus/pp65-specific CD8 T cells of healthy volunteers, we optimized the culture conditions by adjusting the dose and timing of IL-21 treatment. Read More

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http://dx.doi.org/10.2217/imt-2018-0095DOI Listing
February 2019

Physiological functions of Wilms' tumor 1-associating protein and its role in tumourigenesis.

J Cell Biochem 2019 Feb 12. Epub 2019 Feb 12.

Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong, P. R. China.

The Wilms' tumor-associated gene WT1 encodes a tumor suppressor gene, which is implicated in renal differentiation and development of adult urogenital system. Wilms' tumor 1-associating protein (WTAP) is initially identified as a nuclear protein that specifically interacts with WT1 in both in vitro and in vivo assays. WTAP is ubiquitously expressed in different tissues and various growth periods, and its expression is involved in cell cycle, RNA splicing and stabilization, N6-methyladenosine RNA modification, cell proliferation, and apoptosis as well as embryonic development. Read More

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http://dx.doi.org/10.1002/jcb.28402DOI Listing
February 2019
1 Read

Indications and results of diagnostic biopsy in pediatric renal tumors: A retrospective analysis of 317 patients with critical review of SIOP guidelines.

Pediatr Blood Cancer 2019 Feb 12:e27641. Epub 2019 Feb 12.

Imaging Department, Institut Curie, Paris, France.

Objectives: According to the Renal Tumor Study Group (RTSG) of the International Society of Paediatric Oncology (SIOP), diagnostic biopsy of renal tumors prior to neoadjuvant chemotherapy is not mandatory unless the presentation is atypical for a Wilms tumor (WT). This study addresses the relevance of this strategy as well as the accuracy and safety of image-guided needle biopsy.

Methods: Clinical, radiological, and pathological data from 317 children (141 males/176 females, mean age: 4 years, range, 0-17. Read More

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http://dx.doi.org/10.1002/pbc.27641DOI Listing
February 2019

Bifocal germinoma in a patient with 16p11.2 microdeletion syndrome.

Endocrinol Diabetes Metab Case Rep 2019 Feb 7;2019. Epub 2019 Feb 7.

Department of Endocrinology, Diabetes and Metabolism.

Intracranial germinomas are rare tumors affecting mostly patients at young age. Therefore, molecular data on its etiopathogenesis are scarce. We present a clinical case of a male patient of 25 years with an intracranial germinoma and a 16p11. Read More

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http://dx.doi.org/10.1530/EDM-18-0149DOI Listing
February 2019
7 Reads

Expression of cyclin D1 in clear cell sarcoma of kidney. Is it useful in differentiating it from its histological mimics?

Diagn Pathol 2019 Feb 8;14(1):13. Epub 2019 Feb 8.

Department of Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi, Pakistan.

Background: Clear cell sarcoma of the kidney (CCSK) is a rare malignant pediatric renal neoplasm with a heterogeneous histological appearance which often results in misdiagnosis. There are no specific immunohistochemical markers which can help in differentiating CCSK from other pediatric renal neoplasms. Recently Cyclin D1 has been investigated as a possible marker in this regard. Read More

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http://dx.doi.org/10.1186/s13000-019-0790-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368701PMC
February 2019
1 Read

Botryoid Wilms Tumor: A Rare Diagnosis With an Atypical Presentation.

Urology 2019 Feb 5. Epub 2019 Feb 5.

Department of Urology, University of Tennessee Health Science Center, Memphis, TN; Division of Pediatric Urology, LeBonheur Children's Hospital, Memphis, TN; Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN. Electronic address:

Wilms tumor commonly presents as an asymptomatic abdominal mass. In some cases, it can be accompanied with hypertension, constitutional symptoms, and hematuria when involving the collecting system. Below, we review the case of a child diagnosed with botryoid Wilms tumor involving the upper calyces and renal pelvis in which the presenting symptom was a concern for a foreign body in her left ear, and the only abnormality during initial history and physical examination was stage II hypertension. Read More

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http://dx.doi.org/10.1016/j.urology.2019.01.023DOI Listing
February 2019

Educational Case: Wilms Tumor (Nephroblastoma).

Acad Pathol 2019 Jan-Dec;6:2374289518821381. Epub 2019 Jan 15.

Eastern Virginia Medical School, Norfolk, VA, USA.

http://journals.sagepub.com/doi/10. Read More

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http://dx.doi.org/10.1177/2374289518821381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343435PMC
January 2019

Achieving Complete Remission of Hepatocellular Carcinoma: A Significant Predictor for Recurrence-Free Survival after Liver Transplantation.

Can J Gastroenterol Hepatol 2019 8;2019:5796074. Epub 2019 Jan 8.

Department of Medicine B for Gastroenterology and Hepatology, University Hospital Muenster, 48149 Muenster, Germany.

Background: Liver transplantation (LT) is a curative treatment for hepatocellular carcinoma (HCC) and the underlying primary liver disease; however, tumor recurrence is still a major issue. Therefore, the aim of this study was to assess predictors and risk factors for HCC recurrence after LT in patients within and outside the Milan criteria with a special focus on the impact of different bridging strategies.

Methods: All patients who underwent LT for HCC between 07/2002 and 09/2016 at the University Hospital of Muenster were consecutively included in this retrospective study. Read More

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https://www.hindawi.com/journals/cjgh/2019/5796074/
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http://dx.doi.org/10.1155/2019/5796074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341263PMC
January 2019
2 Reads

Long non-coding RNA WT1-AS inhibits cell aggressiveness via miR-203a-5p/FOXN2 axis and is associated with prognosis in cervical cancer.

Eur Rev Med Pharmacol Sci 2019 Jan;23(2):486-495

Department of Obstetrics and Gynecology, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang, China.

Objective: Substantial evidence has demonstrated that long non-coding RNAs (lncRNAs) play pivotal roles in tumorigenesis and tumor progression. The lncRNA Wilms tumor 1 Antisense RNA (WT1-AS) is a potential tumor suppressor in some types of cancers. The objective of this study was to evaluate the biological roles of WT1-AS in cervical cancer. Read More

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http://dx.doi.org/10.26355/eurrev_201901_16860DOI Listing
January 2019
2 Reads

Wilms tumor 1 expression: addressing the 'elephant' in MDS.

Leuk Lymphoma 2019 Feb 4:1-2. Epub 2019 Feb 4.

a Leukemia Program, Department of Hematology and Medical Oncology , Taussig Cancer Institute, Cleveland Clinic , Cleveland , OH , USA.

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http://dx.doi.org/10.1080/10428194.2018.1516882DOI Listing
February 2019

The Rare Association of Cleft Lip and/or Palate and Wilms Tumor.

Cleft Palate Craniofac J 2019 Feb 3:1055665618824440. Epub 2019 Feb 3.

3 Division of Plastic Surgery, Children's Mercy Hospital, Kansas City, MO, USA.

There is currently no recognized connection between the occurrence of cleft lip and/or palate (CL/P) and Wilms tumor (WT). A retrospective review of cleft team records (2001-2015) revealed 3 cases of children, all male, with concomitant diagnoses of CL/P and WT treated at our institution. These patients presented as infants for care of their CL/P, all with additional congenital anomalies, developmental delays, and growth delays. Read More

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http://dx.doi.org/10.1177/1055665618824440DOI Listing
February 2019
4 Reads

Immunohistochemistry and morphometric analysis of pelviureteric junction complexes in children with hydronephrosis.

Indian J Pathol Microbiol 2019 Jan-Mar;62(1):49-53

Ashish Hospital and Research Centre, Jabalpur, Madhya Pradesh, India.

Aim: The study aimed to analyze the musculature and innervations of pelviureteric junction (PUJ) complex and upper ureter by morphometry and immunohistochemistry in surgically resected specimens of PUJ obstruction and compares the findings with normal controls.

Materials And Methods: Specimens of the PUJ were obtained from twenty patients with hydronephrosis due to PUJ obstruction undergoing surgical treatment in this unit from 2013 to 2015. In the control group, seven PUJ complexes were taken from patients who had nephrectomy due to trauma and Wilms tumor. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_535_17DOI Listing
February 2019

The genetic changes of Wilms tumour.

Nat Rev Nephrol 2019 Jan 31. Epub 2019 Jan 31.

Wellcome Sanger Institute, Cambridge, UK.

Wilms tumour is the most common renal malignancy of childhood. The disease is curable in the majority of cases, albeit at considerable cost in terms of late treatment-related effects in some children. However, one in ten children with Wilms tumour will die of their disease despite modern treatment approaches. Read More

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http://dx.doi.org/10.1038/s41581-019-0112-0DOI Listing
January 2019

Lessons from a patient with cardiac arrest due to massive pulmonary embolism as the initial presentation of Wilms tumor: a case report and literature review.

BMC Pediatr 2019 Jan 31;19(1):39. Epub 2019 Jan 31.

Department of Pediatrics, JA Toride Medical Center, 2-1-1, Hongo, Toride, Ibaraki, Japan.

Background: Finding an abdominal mass or hematuria is the initial step in diagnosing Wilms tumor. As the first manifestation of Wilms tumor, it is exceedingly rare for pulmonary tumor embolism to present with cardiac arrest. A case of a patient whose sudden cardiac arrest due to massive pulmonary tumor embolism of Wilms tumor was not responsive to resuscitation is presented. Read More

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http://dx.doi.org/10.1186/s12887-019-1413-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354414PMC
January 2019
2 Reads

A case of ovarian teratoma with nephroblastoma presenting spontaneous rupture.

J Obstet Gynaecol Res 2019 Jan 30. Epub 2019 Jan 30.

Department of Obstetrics and Gynecology, Tokyo Women's Medical University, Tokyo, Japan.

Nephroblastoma (also known as Wilms' tumor) mainly occurs in the kidneys of children. Nephroblastoma outside the kidneys may be observed in three situations: primary disease, metastatic disease and nephroblastoma arising in teratoma. Teratoma with nephroblastoma (TWN) of the adult ovary is a rare tumor and only one case has been reported. Read More

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http://dx.doi.org/10.1111/jog.13887DOI Listing
January 2019

The role of N-methyladenosine RNA methylation in the heat stress response of sheep (Ovis aries).

Cell Stress Chaperones 2019 Jan 30. Epub 2019 Jan 30.

Key Laboratory of Animal Genetics and Breeding and Reproduction of Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.

With the intensive development of the sheep industry and increasing global temperatures, heat stress in sheep has become an increasingly severe and important issue in recent years. The level of N-methyladenosine (mA) RNA methylation changes in response to stress plays important roles in stress responses. However, the role of mA in the heat stress response of sheep remains unclear. Read More

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http://dx.doi.org/10.1007/s12192-018-00965-xDOI Listing
January 2019
1 Read

Molecular Measurable Residual Disease Testing of Blood During AML Cytotoxic Therapy for Early Prediction of Clinical Response.

Front Oncol 2018 15;8:669. Epub 2019 Jan 15.

Laboratory of Myeloid Malignancies, Hematology Branch, National Heart, Lung and Blood Institute, Bethesda, MD, United States.

Measurable residual disease (MRD) testing after initial chemotherapy treatment can predict relapse and survival in acute myeloid leukemia (AML). However, it has not been established if repeat molecular or genetic testing during chemotherapy can offer information regarding the chemotherapy sensitivity of the leukemic clone. Blood from 45 adult AML patients at day 1 and 4 of induction ( = 35) or salvage ( = 10) cytotoxic chemotherapy was collected for both quantitative real-time PCR (qPCR) assessment () and next generation sequencing (>500 × depth) of 49 gene regions recurrently mutated in MDS/AML. Read More

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http://dx.doi.org/10.3389/fonc.2018.00669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341003PMC
January 2019

Determining the optimal cutoff point for lymph node density and its impact on overall survival in children with Wilms' tumor.

Cancer Manag Res 2019 15;11:759-766. Epub 2019 Jan 15.

Clinical Research Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China,

Objective: Previous studies showed that the lymph node density (LND) was a predictor of survival in Wilms' tumor (WT). However, the optimal LND cutoff point is controversial due to methodological shortcomings of previous studies, and no studies have shown the effect of LND on survival in children with WT. The purpose of this study was to remedy this situation. Read More

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http://dx.doi.org/10.2147/CMAR.S190138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339645PMC
January 2019

TRIM28 haploinsufficiency predisposes to Wilms tumor.

Int J Cancer 2019 Jan 29. Epub 2019 Jan 29.

Department of Pediatrics and Adolescent Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.

Two percent of patients with Wilms tumors have a positive family history. In many of these cases the genetic cause remains unresolved. By applying germline exome sequencing in two families with two affected individuals with Wilms tumors, we identified truncating mutations in TRIM28. Read More

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http://dx.doi.org/10.1002/ijc.32167DOI Listing
January 2019

Synchronous Bilateral Wilms Tumor: Five-Year Single-Center Experience with Assessment of Quality of Life.

J Indian Assoc Pediatr Surg 2019 Jan-Mar;24(1):52-60

Department of Pathology, SSKM and IPGMER Medical College and Hospital, Kolkata, West Bengal, India.

Context: Synchronous Bilateral Wilms tumor (sBWT).

Aims: This study aimed to assess the outcome of patients with sBWT treated on SIOP protocol.

Settings And Design: Retrospective and prospective randomized study. Read More

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http://dx.doi.org/10.4103/jiaps.JIAPS_42_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322171PMC
January 2019

Urinary tract anomalies and urinary tract dysfunction in children with Hirschsprung disease-Is follow-up indicated?

J Pediatr Surg 2018 Dec 27. Epub 2018 Dec 27.

Department of Pediatric surgery, Skane University Hospital Lund, Institution of Clinical Sciences, Department of Pediatrics, 221 85 Lund, Sweden.

Background/purpose: Urinary tract function in children with Hirschsprung disease (HD) is rarely considered.

Aim: to evaluate the prevalence of urinary tract anomalies and dysfunction in children with HD compared to controls.

Methods: This was an observational cross sectional case-control study. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2018.12.006DOI Listing
December 2018
2 Reads

High-dose chemotherapy and autologous hematopoietic stem-cell rescue for treatment of relapsed and refractory Wilms tumor: Re-evaluating outcomes.

Pediatr Hematol Oncol 2019 Jan 25:1-6. Epub 2019 Jan 25.

a Division of Hematology, Department of Pediatrics, Oncology and Stem Cell Transplant, Ann and Robert H. Lurie Children's Hospital of Chicago, Feinberg School of Medicine , Northwestern University , Chicago , Illinois , USA.

Wilms tumor (WT) treatment regimens are curative for more than 80% of patients, but those with relapsed or refractory disease continue to have poor outcomes. High-dose chemotherapy followed by autologous stem cell rescue is often utilized although outcomes remain variable. We report on HD-ASCR outcomes in 24 patients with relapsed or refractory Wilms tumor. Read More

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http://dx.doi.org/10.1080/08880018.2018.1532478DOI Listing
January 2019

Inhibition of Heme Oxygenase-1 Activity Enhances Wilms Tumor-1-Specific T-Cell Responses in Cancer Immunotherapy.

Int J Mol Sci 2019 Jan 23;20(3). Epub 2019 Jan 23.

Institute for Transfusion Medicine, Hannover Medical School, 30625 Hannover, Germany.

Wilms tumor protein-1 (WT1) is an attractive target for adoptive T-cell therapy due to its expression in solid tumors and hematologic malignancies. However, T cells recognizing WT1 occur in low frequencies in the peripheral blood of healthy donors, limiting potential therapeutic possibilities. Tin mesoporphyrin (SnMP) is known to inhibit heme oxygenase-1 (HO-1), which has been shown to boost the activation and proliferation of human virus-specific T cells. Read More

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http://dx.doi.org/10.3390/ijms20030482DOI Listing
January 2019

Chemoport-related Fungemia Caused by Trichosporon asahii.

J Pediatr Hematol Oncol 2019 Jan 22. Epub 2019 Jan 22.

Department of Pharmacy Practice, Amrita School of Pharmacy.

Trichosporon asahii is a rare opportunistic fungal pathogen that causes fatal systemic infection in immunocompromised patients. Neutropenia developing due to malignancies is an important risk factor for fungal infection. Invasive infections due to T. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001420DOI Listing
January 2019

Adenocarcinoma of the Rete Testis: Clinicopathologic and Immunohistochemical Characterization of 6 Cases and Review of the Literature.

Am J Surg Pathol 2019 Jan 22. Epub 2019 Jan 22.

Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN.

Adenocarcinoma of the rete testis is rare and its etiological and pathologic characteristics are not well studied. We therefore investigated the clinical, morphologic, and immunohistochemical features of 6 cases diagnosed at our institution and conducted a detailed review of the literature. The mean age was 64 years. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001219DOI Listing
January 2019
7 Reads

Correlations between Histological and Array Comparative Genomic Hybridization Characterizations of Wilms Tumor.

Pathol Oncol Res 2019 Jan 23. Epub 2019 Jan 23.

Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, No.110, Sec 1, Chien Kuo North Road, Taichung, 402, Taiwan.

Wilms tumor, or nephroblastoma, is the most common pediatric renal malignancy. Its diagnosis is principally based on histology. Several genetic loci have been shown to be associated with Wilms tumor formation, including WT1, WT2, FWT1, FWT2, CTNNB1, WTX, and TP53. Read More

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http://dx.doi.org/10.1007/s12253-019-00601-8DOI Listing
January 2019

Weighted gene co‑expression network analysis for identifying hub genes in association with prognosis in Wilms tumor.

Mol Med Rep 2019 Mar 21;19(3):2041-2050. Epub 2019 Jan 21.

Department of Urology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450014, P.R. China.

Wilms tumor (WT) is the most common type of renal malignancy in children. Survival rates are low and high‑risk WT generally still carries a poor prognosis. To better elucidate the pathogenesis and tumorigenic pathways of high‑risk WT, the present study presents an integrated analysis of RNA expression profiles of high‑risk WT to identify predictive molecular biomarkers, for the improvement of therapeutic decision‑making. Read More

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http://dx.doi.org/10.3892/mmr.2019.9881DOI Listing
March 2019
1 Read

The Wilms tumor gene (WT1) (+ / - KTS) isoforms regulate steroidogenesis by modulating the PI3K/AKT and ERK1/2 pathways in bovine granulosa cells.

Biol Reprod 2019 Jan 14. Epub 2019 Jan 14.

College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China.

The Wilms' tumor (WT) gene WT1 encodes the splicing variants WT1(+ KTS) and WT1(- KTS). Recent data suggest that WT1 plays an important role in the development of mice follicles. However, the mechanism through which WT1 influences ovarian steroidogenesis remains unknown. Read More

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https://academic.oup.com/biolreprod/advance-article/doi/10.1
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http://dx.doi.org/10.1093/biolre/ioz003DOI Listing
January 2019
7 Reads

Clinical and Radiographic Characteristics of Atypical Slipped Capital Femoral Epiphysis.

J Pediatr Orthop 2019 Jan 14. Epub 2019 Jan 14.

Department of Orthopedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Slipped capital femoral epiphysis (SCFEs) can be idiopathic or atypical (associated with renal failure, radiation therapy, and endocrine disorders). It is important to estimate the likelihood that atypical SCFE shows different clinical and radiographic characteristics and complications with typical SCFEs.

Methods: We retrospectively reviewed 53 patients (66 hips) with SCFEs managed between 1995 and 2016. Read More

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http://dx.doi.org/10.1097/BPO.0000000000001339DOI Listing
January 2019
6 Reads

Immunohistochemical analysis of cyclin A expression in Wilms tumor.

PeerJ 2019 11;6:e6212. Epub 2019 Jan 11.

Laboratory of Molecular Biology and Endocrinology, Vinča Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia.

Background: Cyclin A overexpression is found in a variety of human tumors and correlates with unfavorable outcome. We analyzed immunohistochemical expression of cyclin A in Wilms tumor (WT) in relation to clinicopathological characteristics, preoperative chemotherapy (PrOpChTh), and overall survival (OS).

Methods: This retrospective study involved 43 patients who underwent nephrectomy from January 1996 to October 2010. Read More

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https://peerj.com/articles/6212
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http://dx.doi.org/10.7717/peerj.6212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330955PMC
January 2019
4 Reads

Altered VEGF Splicing Isoform Balance in Tumor Endothelium Involves Activation of Splicing Factors Srpk1 and Srsf1 by the Wilms' Tumor Suppressor Wt1.

Cells 2019 Jan 11;8(1). Epub 2019 Jan 11.

Université Côte d'Azur, Institute of Biology Valrose, Nice (iBV), CNRS UMR7277, INSERM U1091, 06107 Nice, France.

Angiogenesis is one hallmark of cancer. Vascular endothelial growth factor (VEGF) is a known inducer of angiogenesis. Many patients benefit from antiangiogenic therapies, which however have limitations. Read More

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http://dx.doi.org/10.3390/cells8010041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356959PMC
January 2019

Solid tumor screening recommendations in trisomy 18.

Am J Med Genet A 2019 Mar 13;179(3):455-466. Epub 2019 Jan 13.

Division of Medical Genetics, Department of Pediatrics, Saint Louis University School of Medicine and SSM Cardinal Glennon Children's Hospital, St. Louis, Missouri.

The purpose of this study was to determine whether trisomy 18 patients are at an increased risk of tumor development and require formal tumor screening recommendations. A literature search of trisomy 18 patients with reports of tumors or malignancies, and compilation of all previously reported as well as new unreported cases was performed. 67 patients with trisomy 18 were found to have documented malignancies. Read More

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http://dx.doi.org/10.1002/ajmg.a.61029DOI Listing
March 2019
1 Read

Design of Peptide-Based Nanovaccines Targeting Leading Antigens From Gynecological Cancers to Induce HLA-A2.1 Restricted CD8 T Cell Responses.

Front Immunol 2018 21;9:2968. Epub 2018 Dec 21.

Department of Immunology, Faculty of Medicine, Nursing and Health Sciences, Central Clinical School, Monash University, Melbourne, VIC, Australia.

Gynecological cancers are a leading cause of mortality in women. CD8 T cell immunity largely correlates with enhanced survival, whereas inflammation is associated with poor prognosis. Previous studies have shown polystyrene nanoparticles (PSNPs) are biocompatible, do not induce inflammation and when used as vaccine carriers for model peptides induce CD8 T cell responses. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02968
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http://dx.doi.org/10.3389/fimmu.2018.02968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315164PMC
December 2018
7 Reads

Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression.

Nat Commun 2019 01 10;10(1):112. Epub 2019 Jan 10.

Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, GuangDong, 510515, China.

Wilms tumor gene on the X chromosome (WTX) is a putative tumor suppressor gene in Wilms tumor, but its expression and functions in other tumors are unclear. Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in women and the second leading cause in men in the United States. We demonstrated that WTX frequently lost in CRC which was highly correlated with cell proliferation, tumor invasion and metastasis. Read More

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http://www.nature.com/articles/s41467-018-07998-x
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http://dx.doi.org/10.1038/s41467-018-07998-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328557PMC
January 2019
21 Reads

Paediatric nephrectomy: Patterns, indications and outcome in a developing country.

Malawi Med J 2018 06;30(2):94-98

Sub-Department of Paediatric Surgery, Faculty of Medical Sciences, College of Medicine, University of Nigeria, Ituku/Ozalla Campus, Enugu, Nigeria.

Background: Patterns of and indications for nephrectomy vary in different age groups, geographical locations and time periods. In some series nephrectomies were mainly for malignant conditions while in others they were predominantly for non-malignant conditions. Such data on patterns, indications, and outcomes of nephrectomy in children is limited in our environment. Read More

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https://www.ajol.info/index.php/mmj/article/view/174382
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http://dx.doi.org/10.4314/mmj.v30i2.8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307073PMC
June 2018
5 Reads

A Case of Primary Paratesticular Wilms Tumor in an Undescended Testis.

Urology 2019 Jan 2. Epub 2019 Jan 2.

Children's Hospital Wisconsin and Medical College of Wisconsin Milwaukee, WI.

Extrarenal Wilms tumor is rare. We describe the first reported case of primary paratesticular extrarenal Wilms tumor with regional metastasis in 8-month old male with left undescended testis. Patient underwent left radical orchiectomy with regional lymph node excision. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00904295183134
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http://dx.doi.org/10.1016/j.urology.2018.12.024DOI Listing
January 2019
5 Reads

rs1042522 C>G polymorphism and Wilms tumor susceptibility in Chinese children: a four-center case-control study.

Biosci Rep 2019 Jan 22;39(1). Epub 2019 Jan 22.

Department of Pediatric Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China

Wilms tumor is the most common renal malignancy that occurs in children. gene is considered as a tumor-suppressing gene through controlling cell growth. gene rs1042522 C>G (Arg72Pro) polymorphism is widely investigated in various types of cancers. Read More

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http://bioscirep.org/lookup/doi/10.1042/BSR20181891
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http://dx.doi.org/10.1042/BSR20181891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340947PMC
January 2019
2 Reads

Curcumin as a therapeutic agent in leukemia.

J Cell Physiol 2019 Jan 4. Epub 2019 Jan 4.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Leukemia comprises a group of hematological malignancies responsible for 8% of all cancers and is the most common cancer in children. Despite significant improvements in leukemia treatment, the efficacy of conventional chemotherapeutic agents is low and the disease carries a poor prognosis with frequent relapses and high mortality. Curcumin is a yellow polyphenol compound with diverse pharmacological actions including anticancer, antioxidant, antidiabetic, anti-inflammatory, immunomodulatory, hepatoprotective, lipid-regulating, antidepressant, and antiarthritic. Read More

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http://doi.wiley.com/10.1002/jcp.28072
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http://dx.doi.org/10.1002/jcp.28072DOI Listing
January 2019
4 Reads

Pharmacotherapeutic Management of Wilms Tumor: An Update.

Paediatr Drugs 2019 Feb;21(1):1-13

UCL Great Ormond Street Hospital Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.

Although differences exist in treatment and risk-stratification strategies for children with Wilms tumor (WT) between the European [International Society of Paediatric Oncology (SIOP)] and American [Children's Oncology Group (COG)] study groups, outcomes are very similar, with an overall survival of > 85%. Future strategies aim to de-intensify treatment and reduce toxicity for children with a low risk of relapse and intensify treatment for children with high-risk disease. For metastatic WT, response of lung nodules to chemotherapy is used as a marker to modify treatment intensity. Read More

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http://dx.doi.org/10.1007/s40272-018-0323-zDOI Listing
February 2019

"No drain" uniportal thoracoscopic resection for posterior mediastinal paravertebral Mullerian cyst.

Ann Transl Med 2018 Dec;6(23):462

Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.

Mediastinal Mullerian cyst was first reported by Hattori in 2005. We report a case of a posterior mediastinal paravertebral cyst found incidentally by surveillance chest roentgenogram in a 44-year-old woman. She had a "no drain" uniportal thoracoscopic removal procedure, and histologic examination showed single layer of columnar epithelial lining that stained positive for estrogen receptors (ER), progesterone receptors (PR), paired box gene 8 (PAX8), and Wilms' tumor protein 1 (WT-1), confirming the diagnosis of mediastinal Mullerian cyst. Read More

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http://dx.doi.org/10.21037/atm.2018.10.63DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312802PMC
December 2018

Adult Wilms Tumor During Pregnancy: Case Report and Literature Review.

Urology 2018 Dec 28. Epub 2018 Dec 28.

University of Colorado, Department of Surgery, Division of Urology, Aurora, CO. Electronic address:

Adult Wilms tumor (WT) is a well-known, albeit rare entity and has historically been associated with worse overall clinical outcomes when compared to younger patients. Because WT is uncommon in adult patients, it is often misdiagnosed and treated off standardized pediatric protocols. WT associated with pregnancy is even more rare, and there is not a standardized approach to this small subset of patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00904295183134
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http://dx.doi.org/10.1016/j.urology.2018.11.045DOI Listing
December 2018
5 Reads

Foundation of pediatric cancer treatment in Lao People's Democratic Republic at the Lao-Korea National Children's Hospital.

Pediatr Hematol Oncol 2018 May 31;35(4):268-275. Epub 2018 Dec 31.

b Department of Pediatrics , Seoul National University College of Medicine , Seoul , Republic of Korea.

Aim: The Lao-Korea National Children's Hospital initiated and developed a pediatric cancer treatment program for the first time in September 2012, through education by the Lee Jong-Wook project, establishment of infrastructure by the Korea International Cooperation Agency, and cooperation of medical staff.

Material And Methods: we describe the experience of initiating and building this program by retrospectively reviewing the data from pediatric patients with cancer diagnosed at the Lao-Korea National Children's Hospital between September 2012 and December 2016.

Results: A total of 78 patients diagnosed with acute lymphoblastic leukemia (ALL) (n = 44), acute myeloid leukemia (AML) (n = 12), chronic myeloid leukemia (n = 7), lymphoma (n = 6), retinoblastoma (n = 5), Wilms tumor (n = 3), and germ cell tumor (n = 1) were included. Read More

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http://dx.doi.org/10.1080/08880018.2018.1477888DOI Listing
May 2018
2 Reads

Platforms of in vivo genome editing with inducible Cas9 for advanced cancer modeling.

Cancer Sci 2018 Dec 26. Epub 2018 Dec 26.

Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.

The emergence of clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 technology has dramatically advanced how we manipulate the genome. Regarding in vivo experiments, Cas9-transgenic animals could provide efficient and complex genome editing. However, this potential has not been fully realized partly due to a lack of convenient platforms and limited examples of successful disease modeling. Read More

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http://doi.wiley.com/10.1111/cas.13924
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http://dx.doi.org/10.1111/cas.13924DOI Listing
December 2018
12 Reads

α-1,2-Mannosidase MAN1C1 Inhibits Proliferation and Invasion of Clear Cell Renal Cell Carcinoma.

J Cancer 2018 24;9(24):4618-4626. Epub 2018 Nov 24.

Department of Urology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.

: This study investigated the biological function of the gene MAN1C1 α-mannosidase in renal cell carcinoma. It has been reported that MAN1C1 is probably a potential tumor suppressor gene in Wilms. However, the role of MAN1C1 in human clear cell renal cell carcinoma (ccRCC) has not been reported. Read More

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http://dx.doi.org/10.7150/jca.27673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299394PMC
November 2018
2 Reads

p53, stem cell biology and childhood blastomas.

Curr Opin Oncol 2019 Mar;31(2):84-91

Department of Paediatrics, University of Malaya, Kuala Lumpur, Malaysia.

Purpose Of Review: Childhood blastomas, unlike adult cancers, originate from developing organs in which molecular and cellular features exhibit differentiation arrest and embryonic characteristics. Conventional cancer therapies, which rely on the generalized cytotoxic effect on rapidly dividing cells, may damage delicate organs in young children, leading to multiple late effects. Deep understanding of the biology of embryonal cancers is crucial in reshaping the cancer treatment paradigm for children. Read More

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http://dx.doi.org/10.1097/CCO.0000000000000504DOI Listing