12,918 results match your criteria Wilms Tumor


Imputing missing RNA-sequencing data from DNA methylation by using a transfer learning-based neural network.

Gigascience 2020 Jul;9(7)

School of Data and Computer Science, Sun Yat-sen University, 132 East Waihuan Road, Guangzhou 510006, China.

Background: Gene expression plays a key intermediate role in linking molecular features at the DNA level and phenotype. However, owing to various limitations in experiments, the RNA-seq data are missing in many samples while there exist high-quality of DNA methylation data. Because DNA methylation is an important epigenetic modification to regulate gene expression, it can be used to predict RNA-seq data. Read More

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http://dx.doi.org/10.1093/gigascience/giaa076DOI Listing

MiR-200c inhibits proliferation and promotes apoptosis of Wilms tumor cells by regulating akt signaling pathway.

Eur Rev Med Pharmacol Sci 2020 Jun;24(12):6623-6631

Department of Pediatrics, Shan County Central Hospital of Heze City, Heze, China.

Objective: The aim of this study was to explore the effect of micro ribonucleic acid (miR)-200c on the proliferation and apoptosis of Wilms tumor cells, and to further elucidate its potential mechanisms.

Patients And Methods: Reverse Transcription-Polymerase Chain Reaction (RT-PCR) was used to detect the expression level of miR-200c in cancer tissues and adjacent normal tissues of 20 patients with Wilms tumor. Human primary Wilms tumor cells were taken as research objects, and were divided into Control group and miR-200c mimic group. Read More

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http://dx.doi.org/10.26355/eurrev_202006_21648DOI Listing

Analysis of wt1a reporter line expression levels during proepicardium formation in the zebrafish.

Histol Histopathol 2020 Jul 7:18238. Epub 2020 Jul 7.

Department of Anatomy, Histology and Neuroscience, School of Medicine, Autonoma University of Madrid, Madrid. Spain.

The epicardium is the outer mesothelial layer of the heart. It covers the myocardium and plays important roles in both heart development and regeneration. It is derived from the proepicardium (PE), groups of cells that emerges at early developmental stages from the dorsal pericardial layer (DP) close to the atrio-ventricular canal and the venous pole of the heart-tube. Read More

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http://dx.doi.org/10.14670/HH-18-238DOI Listing

Association between the Wilms tumor-1 rs16754 polymorphism and acute myeloid leukemia: A MOOSE-compliant meta-analysis.

Medicine (Baltimore) 2020 Jul;99(27):e20713

Department of Burn Surgery, The First Hospital of Jilin University, Changchun, China.

The Wilms tumor-1 (WT1) protein is an important regulator of malignant hematopoiesis and has been implicated in the pathogenesis of acute myeloid leukemia (AML). Recently special attention has been paid to the relationship of the WT1 single nucleotide polymorphism (SNP) rs16754 with AML risk and outcome, but the conflicting results made it difficult to draw definitive conclusions. In the present study, we systematically reviewed the literature and performed a meta-analysis of existing evidence. Read More

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http://dx.doi.org/10.1097/MD.0000000000020713DOI Listing

Incidence, treatment, and outcomes of primary and recurrent Non-Wilms renal tumors in children: Report of 109 patients treated at a single institution.

J Pediatr Urol 2020 Jun 5. Epub 2020 Jun 5.

Homi Bhabha National Institute (HBNI), Mumbai, India; Department of Nuclear Medicine, Tata Memorial Centre, Bombay, India.

Introduction: Non-Wilms renal tumors represent a compelling subset of childhood renal tumors. However, their relative rarity renders accurate diagnosis, and therapy challenging which in some instance is inferred from their adult counterparts.

Objective: To describe the incidence and analyze the diagnostic challenges, therapies and, outcomes of non-Wilms renal tumors at the largest tertiary cancer centre in India. Read More

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http://dx.doi.org/10.1016/j.jpurol.2020.05.168DOI Listing

Comparison of models of diffusion in Wilms' tumours and normal contralateral renal tissue.

MAGMA 2020 Jul 2. Epub 2020 Jul 2.

Great Ormond Street Institute of Child Health, University College London, 30 Guilford St, Holborn, London, WC1N 1EH, UK.

Objective: ADC (Apparent Diffusion Coefficient) derived from Diffusion-Weighted Imaging (DWI) has shown promise as a non-invasive quantitative imaging biomarker in Wilms' tumours. However, many non-Gaussian models could be applied to DWI. This study aimed to compare the suitability of four diffusion models (mono exponential, IVIM [Intravoxel Incoherent Motion], stretched exponential, and kurtosis) in Wilms' tumours and the unaffected contralateral kidneys. Read More

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http://dx.doi.org/10.1007/s10334-020-00862-4DOI Listing

A Morphologic and Immunohistochemical Comparison of Nuclear β-Catenin Expressing Testicular Sertoli Cell Tumors and Pancreatic Solid Pseudopapillary Neoplasms Supporting Their Continued Separate Classification.

Am J Surg Pathol 2020 Jun 26. Epub 2020 Jun 26.

Indiana University School of Medicine, Indianapolis, IN.

Some recent reports suggested that many Sertoli cell tumors, not otherwise specified (SCTs-NOS) of the testis were analogs of the solid pseudopapillary neoplasm (SPN) of the pancreas. One of the most relied on pieces of information for this assertion was the shared occurrence in both neoplasms of exon 3 mutations of the CTNNB1 gene, which was reflected by nuclear β-catenin expression. We, therefore, compared the morphologic and immunohistochemical features of 18 SCTs-NOS with strong, diffuse nuclear β-catenin expression with 16 SPNs that also showed such positivity. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001527DOI Listing

A nomogram for prediction of distant metastasis in children with wilms tumor: A study based on SEER database.

J Pediatr Urol 2020 May 29. Epub 2020 May 29.

Department of Pediatric Urology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China. Electronic address:

Introduction: Accurate diagnosis of distant metastasis especially uncommon site of metastasis (UCM) in patients with Wilms tumor (WTs) is a demanding prerequisite for administration of appropriate therapy and achieving better survival outcome.

Objective: To develop and validate a nomogram to predict probability of distant metastasis, and identify population demanded for rigorous imaging evaluations in children with WTs.

Material And Methods: Data of patients diagnosed with unilateral WTs and aged under 18 years old, were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Read More

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http://dx.doi.org/10.1016/j.jpurol.2020.05.158DOI Listing

Fibrovascular Tumor-Like Lesions of the Facial Nerve.

Audiol Neurootol 2020 Jun 29:1-8. Epub 2020 Jun 29.

Department of Otorhinolaryngology, La Paz University Hospital, Madrid, Spain.

Background: Facial nerve tumors (FNTs) are relatively rare benign lesions that arise from any segment of the facial nerve (FN). About half of all patients present with FN dysfunction, mainly long-standing or progressive facial paralysis. Diagnosis of an FNT is usually based on radiological imaging and confirmed by histological study. Read More

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http://dx.doi.org/10.1159/000508025DOI Listing

Comprehensive Analysis of a Long Noncoding RNA-Associated Competing Endogenous RNA Network in Wilms Tumor.

Cancer Control 2020 Apr-Jun;27(2):1073274820936991

Nanchang University, Nanchang, China.

Long noncoding RNA (lncRNA) plays crucial roles in various biological processes of different cancers, especially acting as a competing endogenous RNA (ceRNA). However, the role of lncRNA-mediated ceRNA in Wilms tumor (WT), which is the most common malignant kidney cancer in children, remains unknown. In present study, RNA sequence profiles and clinical data of 125 patients with WT consisting of 119 tumor and 6 normal tissues from Therapeutically Applicable Research To Generate Effective Treatments database were analyzed. Read More

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http://dx.doi.org/10.1177/1073274820936991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324900PMC

Assessment of somatic mutations in urine and plasma of Wilms tumor patients.

Cancer Med 2020 Jun 26. Epub 2020 Jun 26.

Laboratory of Genomics and Molecular Biology, International Research Center/CIPE, A. C. Camargo Cancer Center, São Paulo, Brazil.

Tumor DNA has been detected in body fluids of cancer patients. Somatic tumor mutations are being used as biomarkers in body fluids to monitor chemotherapy response as a minimally invasive tool. In this study, we evaluated the potential of tracking somatic mutations in free DNA of plasma and urine collected from Wilms tumor (WT) patients for monitoring treatment response. Read More

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http://dx.doi.org/10.1002/cam4.3236DOI Listing

An Uncommon Variant of Wilms Tumor: Botryoid Intrapelvic Renal Mass.

Balkan Med J 2020 Jun 25. Epub 2020 Jun 25.

University of Health Science Turkey, Dr. Lütfi Kırdar Kartal Research and Training Hospital, Clinic of Urology, İstanbul, Turkey.

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http://dx.doi.org/10.4274/balkanmedj.galenos.2020.2020.3.59DOI Listing

WT1 facilitates the self-renewal of leukemia-initiating cells through the upregulation of BCL2L2: WT1-BCL2L2 axis as a new acute myeloid leukemia therapy target.

J Transl Med 2020 Jun 24;18(1):254. Epub 2020 Jun 24.

Laboratory of Internal Medicine, The First Affiliated Hospital of Wenzhou Medical University, 1 Xuefubei Street, Ouhai District, Wenzhou, 325000, Zhejiang, China.

Background: Overexpression of Wilms' tumor-1 (WT1) transcription factor facilitates proliferation in acute myeloid leukemia (AML). However, whether WT1 is enriched in the leukemia-initiating cells (LICs) and leukemia stem cells (LSCs) and facilitates the self-renewal of LSCs remains poorly understood.

Methods: MLL-AF9-induced murine leukemia model was used to evaluate the effect of knockdown of wt1 on the self-renewal ability of LSC. Read More

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http://dx.doi.org/10.1186/s12967-020-02384-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313134PMC

Surrogate-free machine learning-based organ dose reconstruction for pediatric abdominal radiotherapy.

Phys Med Biol 2020 Jun 24. Epub 2020 Jun 24.

Department of Radiation Oncology, Amsterdam UMC, Amsterdam, Noord-Holland, NETHERLANDS.

To study radiotherapy-related adverse effects, detailed dose information (3D distribution) is needed for accurate dose-effect modeling. For childhood cancer survivors who underwent radiotherapy in the pre-CT era, only 2D radiographs were acquired, thus 3D dose distributions must be reconstructed from limited information. State-of-the-art methods achieve this by using 3D surrogate anatomies. Read More

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http://dx.doi.org/10.1088/1361-6560/ab9fccDOI Listing

MiR-22-3p regulates the proliferation and invasion of Wilms' tumor cells by targeting AKT3.

Eur Rev Med Pharmacol Sci 2020 Jun;24(11):5996-6004

Department of Urology, Songshan Hospital of Qingdao University, Qingdao, China.

Objective: In this study, the regulatory mechanism of miR-22-3p/AKT3 in the development of Wilms' tumor (WT) was investigated.

Patients And Methods: Twenty-seven pairs of surgical tumor specimens and adjacent normal tissues were obtained from Jining No. 1 People's Hospital. Read More

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http://dx.doi.org/10.26355/eurrev_202006_21493DOI Listing

Wilms tumors and their precursors: Radiological diagnosis versus histology.

Pediatr Blood Cancer 2020 Jun 22:e28414. Epub 2020 Jun 22.

Department of Visceral Pediatric Surgery, APHP Hôpital Armand Trousseau, Paris, France.

The radiological distinction of Wilms tumor (WT) nodules from nephrogenic rests (NR) in patients with multifocal unilateral WT or bilateral disease is challenging. The study aims to compare the radiology assessment of kidney nodules with their final histology in 48 patients. The final histology of 118 nodules corresponded to the initial radiological diagnosis while 40 (25%) nodules were misdiagnosed, 20 being initially diagnosed WT on imaging were proved to be NR at histology. Read More

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http://dx.doi.org/10.1002/pbc.28414DOI Listing

Reticular Fibroblasts Expressing the Transcription Factor WT1 Define a Stromal Niche That Maintains and Replenishes Splenic Red Pulp Macrophages.

Immunity 2020 Jun 17. Epub 2020 Jun 17.

Aix Marseille Univ, CNRS, INSERM, CIML, Marseille, France. Electronic address:

Located within red pulp cords, splenic red pulp macrophages (RPMs) are constantly exposed to the blood flow, clearing senescent red blood cells (RBCs) and recycling iron from hemoglobin. Here, we studied the mechanisms underlying RPM homeostasis, focusing on the involvement of stromal cells as these cells perform anchoring and nurturing macrophage niche functions in lymph nodes and liver. Microscopy revealed that RPMs are embedded in a reticular meshwork of red pulp fibroblasts characterized by the expression of the transcription factor Wilms' Tumor 1 (WT1) and colony stimulating factor 1 (CSF1). Read More

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http://dx.doi.org/10.1016/j.immuni.2020.06.008DOI Listing

Surgical Approach to Abdominal Tumors Involving the Inferior Vena Cava.

Isr Med Assoc J 2020 Jun;22(6):364-368

Department of Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Background: Abdominal tumors invading the inferior vena cava (IVC) present significant challenges to surgeons and oncologists.

Objectives: To describe a surgical approach and patient outcomes.

Methods: The authors conducted a retrospective analysis of surgically resected tumors with IVC involvement by direct tumor encasement or intravascular tumor growth. Read More

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Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141 dendritic cells to activate naïve and memory WT1-specific CD8 T cells.

Clin Transl Immunology 2020 12;9(6):e1141. Epub 2020 Jun 12.

Cancer Immunotherapies Laboratory Mater Research Institute - The University of Queensland Translational Research Institute Woolloongabba Australia 4102 Australia.

Objectives: Vaccines that prime Wilms' tumor 1 (WT1)-specific CD8 T cells are attractive cancer immunotherapies. However, immunogenicity and clinical response rates may be enhanced by delivering WT1 to CD141 dendritic cells (DCs). The C-type lectin-like receptor CLEC9A is expressed exclusively by CD141 DCs and regulates CD8 T-cell responses. Read More

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http://dx.doi.org/10.1002/cti2.1141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292901PMC

Stromal beta-catenin activation impacts nephron progenitor differentiation in the developing kidney and may contribute to Wilms tumor.

Development 2020 Jun 15. Epub 2020 Jun 15.

Department of Molecular Biology and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA

Wilms tumor (WT) morphologically resembles the embryonic kidney, consisting of blastema, epithelial, and stromal components, suggesting tumors arise from the dysregulation of normal development. Beta-catenin activation is observed in a significant proportion of WTs; however, much remains to be understood about how it contributes to tumorigenesis. While activating beta-catenin mutations are observed in both blastema and stromal components of WT, current models assume that activation in the blastemal lineage is causal. Read More

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http://dx.doi.org/10.1242/dev.189597DOI Listing

LINC00858 facilitates the malignant development of Wilms' tumor by targeting miR-653-5p.

Minerva Med 2020 Jun 12. Epub 2020 Jun 12.

Department of Economic Management, Medical Research Department, Pla Rocket Force Characteristic Medical Center, Beijing, China.

Background: To uncover the clinical significance of LINC00858 in the development of Wilms' tumor and the potential molecular mechanism.

Methods: LINC00858 levels in Wilms' tumor species and cell lines were determined by quantitative real-time polymerase chain reaction (qRT-PCR). The clinical significance of LINC00858 in influencing pathological features and prognosis in patients with Wilms' tumor was analyzed. Read More

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http://dx.doi.org/10.23736/S0026-4806.20.06566-0DOI Listing

Where are the theca cells from: the mechanism of theca cells derivation and differentiation.

Chin Med J (Engl) 2020 Jun 9. Epub 2020 Jun 9.

Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Peking University Third Hospital, Beijing 100191, China.

Mammalian follicles are composed of oocytes, granulosa cells, and theca cells. Theca cells form in the secondary follicles, maintaining follicular structural integrity and secreting steroid hormones. Two main sources of theca cells exist: Wilms tumor 1 positive (Wt1) cells native to the ovary and Gli1 mesenchymal cells migrated from the mesonephros. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000850DOI Listing
June 2020
1.016 Impact Factor

Cystic partially differentiated nephroblastoma: a rare pediatric renal tumor-case report.

Radiol Case Rep 2020 Aug 5;15(8):1133-1137. Epub 2020 Jun 5.

Departamento de Radiologia, Hospital Mater Dei Contorno, Avenida do Contorno, Belo Horizonte, Minas 9000, Brasil.

Cystic partially differentiated nephroblastoma is a rare renal tumor of childhood. It is part of a spectrum of multicystic renal tumors that also includes cystic nephroma and cystic Wilms' tumor. We present a case of cystic partially differentiated nephroblastoma, highlighting the clinical and imaging diagnostic challenge. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280362PMC

Immunotherapy employing dendritic cell vaccination for patients with advanced or relapsed esophageal cancer.

Ther Apher Dial 2020 Jun 10. Epub 2020 Jun 10.

Department of Internal Medicine, Sapporo Hokuyu Hospital.

The prognosis of patients with advanced esophageal cancer is poor despite the recent introduction of immune checkpoint inhibitors. In the present pilot study, we have evaluated the safety and the feasibility of Wilms' tumor 1 (WT1) peptide-pulsed dendritic cell (DC) vaccination in combination with OK-432 in patients with advanced or relapsed esophageal cancer. Fifteen eligible patients were enrolled. Read More

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http://dx.doi.org/10.1111/1744-9987.13542DOI Listing

Challenges on participation in a cooperative group of childhood renal tumors in Brasil.

Rev Assoc Med Bras (1992) 2020 Mar;66(3):284-289

. Centro de Pesquisa, Programa de Pós Graduação, Instituto Nacional de Câncer, Rio de Janeiro, RJ, Brasil.

Objective: Children with renal tumors included in clinical trials have significantly better outcomes. In Brasil, the enrollment of patients in clinical trials remains challenging. Here we aimed to describe participation accrual in the Brazilian Wilms Tumor Study Group (BWTSG) and to identify barriers to trial registration of children with renal tumors. Read More

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http://dx.doi.org/10.1590/1806-9282.66.3.284DOI Listing

First-In-Class CD13-Targeted Tissue Factor tTF-NGR in Patients with Recurrent or Refractory Malignant Tumors: Results of a Phase I Dose-Escalation Study.

Cancers (Basel) 2020 Jun 7;12(6). Epub 2020 Jun 7.

Department of Medicine A, Hematology, Oncology, University Hospital Muenster, D-48149 Muenster, Germany.

Background: Aminopeptidase N (CD13) is present on tumor vasculature cells and some tumor cells. Truncated tissue factor (tTF) with a C-terminal NGR-peptide (tTF-NGR) binds to CD13 and causes tumor vascular thrombosis with infarction.

Methods: We treated 17 patients with advanced cancer beyond standard therapies in a phase I study with tTF-NGR (1-h infusion, central venous access, 5 consecutive days, and rest periods of 2 weeks). Read More

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http://dx.doi.org/10.3390/cancers12061488DOI Listing

Epstein-Barr virus-associated lymphoproliferative disorder in a young child treated for Wilms tumor.

Pediatr Hematol Oncol 2020 Jun 8:1-7. Epub 2020 Jun 8.

Department of Pathology, Loma Linda University Medical Center and School of Medicine, Loma Linda, California, USA.

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http://dx.doi.org/10.1080/08880018.2020.1771491DOI Listing

Malignant teratoid tumor of the thyroid gland: an aggressive primitive multiphenotypic malignancy showing organotypical elements and frequent DICER1 alterations-is the term "thyroblastoma" more appropriate?

Virchows Arch 2020 Jun 7. Epub 2020 Jun 7.

Instituto de Investigação e Inovação em Saúde, Porto, Portugal.

Primary thyroid teratomas are exceedingly rare. Mature and immature variants recapitulate their gonadal counterparts (predilection for infants/children, triphasic germ layer differentiation, and favorable outcome). On the other hand, the so-called malignant teratomas affect predominantly adults and elderly, are highly aggressive, and, according to a few published cases, harbor DICER1 mutations. Read More

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http://dx.doi.org/10.1007/s00428-020-02853-1DOI Listing

The contribution of WTAP gene variants to Wilms tumor susceptibility.

Gene 2020 Jun 3;754:144839. Epub 2020 Jun 3.

Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China. Electronic address:

Wilms tumor is the most frequently occurring pediatric renal malignancy. Wilms tumor suppressor-1-associated protein (WTAP) is a vital component of N6-methyltransferase complex involved in tumorigenesis. However, the roles of WTAP gene single nucleotide polymorphisms (SNPs) in Wilms tumor risk have not been clarified to date. Read More

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http://dx.doi.org/10.1016/j.gene.2020.144839DOI Listing

WT1, PRAME, and PR3 mRNA Expression in Acute Myeloid Leukemia (AML).

J Immunother 2020 Jul/Aug;43(6):204-215

Helmholtz Center Munich, German Research Center for Environmental Health.

Several tumor-associated antigens (TAAs) were recently identified, that could qualify as targets for immunotherapy, they could qualify (on RNA-level) for monitoring of tumor load. Here, we studied the expression levels of the immunogenic antigens PRAME (preferentially expressed antigen of melanoma), WT1 (Wilms' tumor gene), and PR3 (proteinase 3) on myeloid blasts by real-time quantitative polymerase chain reaction and correlated these data to the state and course of disease and to the defined subgroups of acute myeloid leukemia (AML). At first diagnoses, 41 of 47 patients tested showed overexpression of PRAME (87%), 38 of WT1 (81%), and 26 of PR3 (55%), with the highest expression levels for PRAME (2048-fold), followed by WT1 (486-fold) and PR3 (196-fold). Read More

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http://dx.doi.org/10.1097/CJI.0000000000000322DOI Listing

SOX6 is a Novel Immunohistochemical Marker for Differential Diagnosis of Epithelioid Mesothelioma From Lung Adenocarcinoma.

Am J Surg Pathol 2020 Jun 2. Epub 2020 Jun 2.

Department of Pathology, Graduate School of Biomedical and Health Science.

The differential diagnosis of epithelioid mesothelioma from lung adenocarcinoma using immunohistochemistry is improving. However, immunohistochemical markers with high sensitivity and specificity have yet to be identified. In this study, we investigated the utility of sex-determining region Y box 6 (SOX6) as a novel immunohistochemical marker, identified by analyzing previous gene expression data. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001507DOI Listing

Intravascular Lobular Capillary Hemangioma (Intravascular Pyogenic Granuloma): A Clinicopathologic Study of 40 Cases.

Am J Surg Pathol 2020 Jun 2. Epub 2020 Jun 2.

Department of Pathology, Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH.

Intravascular lobular capillary hemangioma (ILCH), or intravascular pyogenic granuloma, is relatively rare and likely underrecognized. We reviewed all ILCH cases from our institution confirmed pathologically from 2006 to 2019. Immunostains for smooth muscle actin and Wilms tumor 1 were performed on all cases and prior immunohistochemical stains were reviewed. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001509DOI Listing

MiRNA-203a-5p alleviates the malignant progression of Wilms' tumor via targeting JAG1.

Eur Rev Med Pharmacol Sci 2020 May;24(10):5329-5335

Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objective: To uncover the potential influence of microRNA-203a-5p (miRNA-203a-5p) on the malignant progression of Wilms' tumor (WT).

Patients And Methods: MiRNA-203a-5p levels in 49 paired WT and paracancerous tissues were determined by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). Prognostic value of miRNA-203a-5p in WT was assessed by the Kaplan-Meier method. Read More

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http://dx.doi.org/10.26355/eurrev_202005_21315DOI Listing

Testis formation in XX individuals resulting from novel pathogenic variants in Wilms' tumor 1 () gene.

Proc Natl Acad Sci U S A 2020 Jun 3;117(24):13680-13688. Epub 2020 Jun 3.

Human Developmental Genetics Unit, Institut Pasteur, 75724 Paris, France;

Sex determination in mammals is governed by antagonistic interactions of two genetic pathways, imbalance in which may lead to disorders/differences of sex development (DSD) in human. Among 46,XX individuals with testicular DSD (TDSD) or ovotesticular DSD (OTDSD), testicular tissue is present in the gonad. Although the testis-determining gene is present in many cases, the etiology is unknown in most -negative patients. Read More

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http://dx.doi.org/10.1073/pnas.1921676117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306989PMC

Linagliptin, when compared to placebo, improves CD34+ve endothelial progenitor cells in type 2 diabetes subjects with chronic kidney disease taking metformin and/or insulin: a randomized controlled trial.

Cardiovasc Diabetol 2020 06 3;19(1):72. Epub 2020 Jun 3.

The GW Medical Faculty Associates, 2300 M Street NW, Washington, DC, 20037, USA.

Background: Endothelial Progenitor cells (EPCs) has been shown to be dysfunctional in both type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) leading to poor regeneration of endothelium and renal perfusion. EPCs have been shown to be a robust cardiovascular disease (CVD) risk indicator. Cellular mechanisms of DPP4 inhibitors such as linagliptin (LG) on CVD risk, in patients with T2DM with established CKD has not been established. Read More

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http://dx.doi.org/10.1186/s12933-020-01046-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271387PMC
June 2020
4.015 Impact Factor

LncRNA WTAPP1 promotes cancer cell invasion and migration in NSCLC by downregulating lncRNA HAND2-AS1.

BMC Pulm Med 2020 May 30;20(1):153. Epub 2020 May 30.

Department of Thoracic Surgery, The Second Hospital of Jilin University, No.218 Ziqiang Street, Changchun City, Jilin Province, 130041, People's Republic of China.

Background: Long non-coding RNA (lncRNA) Wilms Tumor 1 Associated Protein Pseudogene 1 (WTAPP1) has been reported to be a critical player in the angiogenesis and migration of endothelial progenitor cells, while its involvement in cancer biology remains unknown. This study was carried out to investigate the role of WTAPP1 in non-small cell lung cancer (NSCLC).

Methods: The expression of WTAPP1 and lncRNA HAND2 Antisense RNA 1 (HAND2-AS1) in plasma and tissues from NSCLC patients was detected by qRT-PCR. Read More

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http://dx.doi.org/10.1186/s12890-020-01180-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260856PMC

Glioma-derived extracellular vesicles promote tumor progression by conveying WT1.

Carcinogenesis 2020 May 28. Epub 2020 May 28.

Department of Immunology, Kanazawa University Graduate School of Medical Sciences, Takara, Kanazawa, Ishikawa, Japan.

Glioma persists as one of the most aggressive primary tumors of the central nervous system. Glioma cells are known to communicate with tumor-associated macrophages/microglia via various cytokines to establish the tumor microenvironment. However, how extracellular vesicles (EVs), emerging regulators of cell-cell communication networks, function in this process is still elusive. Read More

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http://dx.doi.org/10.1093/carcin/bgaa052DOI Listing

Results of Treatment for Patients With Multicentric or Bilaterally Predisposed Unilateral Wilms Tumor (AREN0534): A report from the Children's Oncology Group.

Cancer 2020 Aug 27;126(15):3516-3525. Epub 2020 May 27.

Children's National Hospital, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA.

Background: A primary objective of Children's Oncology Group study AREN0534 (Treatment for Patients With Multicentric or Bilaterally Predisposed, Unilateral Wilms Tumor) was to facilitate partial nephrectomy in 25% of children with bilaterally predisposed unilateral tumors (Wilms tumor/aniridia/genitourinary anomalies/range of developmental delays [WAGR] syndrome; and multifocal and overgrowth syndromes). The purpose of this prospective study was to achieve excellent event-free survival (EFS) and overall survival (OS) while preserving renal tissue through preoperative chemotherapy, completing definitive surgery by 12 weeks from diagnosis, and modifying postoperative chemotherapy based on histologic response.

Methods: The treating institution identified whether a predisposition syndrome existed. Read More

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http://dx.doi.org/10.1002/cncr.32958DOI Listing

HOXB2 and FOXC1 synergistically drive the progression of Wilms tumor.

Exp Mol Pathol 2020 May 21;115:104469. Epub 2020 May 21.

Department of Pediatric Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.

Objective: To uncover the expression patterns of HOXB2 and FOXC1 in Wilms tumor samples, and their synergistical regulations on the development of Wilms tumor.

Methods: Expression levels of HOXB2 and FOXC1 in 58 cases of Wilms tumor tissues and paracancerous ones were detected. The influences of HOXB2 and FOXC1 on prognosis in Wilms tumor patients were analyzed. Read More

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http://dx.doi.org/10.1016/j.yexmp.2020.104469DOI Listing

Prevalence, Epidemiology, Etiology, and Sensitivity of Invasive Bacterial Infections in Pediatric Patients Undergoing Oncological Treatment: A Multicenter Nationwide Study.

Microb Drug Resist 2020 May 20. Epub 2020 May 20.

Department of Pediatric Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University Torun, Bydgoszcz, Poland.

Infectious complications (IC) caused by bacterial strains often impede anticancer therapy. The study aimed to retrospectively analyze bacterial IC that could help predict the risk and optimize the empirical treatment for bacterial infections in pediatric cancer patients. Over a 72-month period, all-in 5,599 children with cancer: 2,441 patients with hematological malignancy (HM including acute leukemias, Hodgkin and non-Hodgkin lymphomas [NHLs], and Langerhans cell histiocytosis) and 3,158 with solid tumors (STs including central nervous system tumors, neuroblastoma, Wilms' tumor, soft tissue sarcoma, germ cell tumors, Ewing sarcoma, osteosarcoma, hepatoblastoma, and others) were enrolled into the study. Read More

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http://dx.doi.org/10.1089/mdr.2019.0393DOI Listing

A systematic review of evidence for and against routine surveillance imaging after completing treatment for childhood extracranial solid tumors.

Cancer Med 2020 May 19. Epub 2020 May 19.

Centre for Reviews and Dissemination, University of York, York, UK.

Background: Regular off-treatment imaging is often used to assess for recurrence of disease after childhood cancer treatment. It is unclear if this increases survival, or what burden surveillance places on patients, families, or health-care services. This systematic review examines the impact of routine surveillance imaging after treatment of pediatric extracranial solid tumors. Read More

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http://dx.doi.org/10.1002/cam4.3110DOI Listing

Comprehensive analysis of competing endogenous RNA network in Wilms tumor based on the TARGET database.

Transl Androl Urol 2020 Apr;9(2):473-484

Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

Background: Wilms tumor (WT) was the most common malignant tumor of urinary system in children. With the advances in gene sequencing, research of molecular mechanism of WT tumor was gradually increasing. However, few studies have explored the influence of competing endogenous RNA (ceRNA) in WT. Read More

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http://dx.doi.org/10.21037/tau.2020.01.34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214997PMC

Recent advances in Wilms tumor predisposition.

Hum Mol Genet 2020 May 15. Epub 2020 May 15.

Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105.

Wilms tumor (WT), the most common childhood kidney cancer, develops in association with an underlying germline predisposition in up to 15% of cases. Germline alterations affecting the WT1 gene and epigenetic alterations affecting the 11p15 locus are associated with a selective increase in WT risk. Nevertheless, WT also occurs in the context of more pleiotropic cancer predispositions, such as DICER1, Li-Fraumeni, and Bloom syndrome, as well as Fanconi anemia. Read More

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http://dx.doi.org/10.1093/hmg/ddaa091DOI Listing

Local Stage dependent necessity of Radiotherapy in Rhabdoid Tumors of the Kidney (RTK) - the GPOH experience.

Int J Radiat Oncol Biol Phys 2020 May 11. Epub 2020 May 11.

Dep. of Pediatric Hematology and Oncology, Saarland University Hospital, Homburg/Saar, Germany.

Background: Rhabdoid tumor of the kidney (RTK) is one of the most aggressive childhood renal tumors. Overall survival ranges from 22 to 47%. Indication for radiotherapy (RTx) in usually very young patients is an ongoing discussion. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2020.04.046DOI Listing

PD-L1 in squamous cell carcinoma of the oral tongue shows gender-specific association with prognosis.

Oral Dis 2020 May 14. Epub 2020 May 14.

Department of Medical Biosciences/Pathology, Umeå University, Umeå, Sweden.

Objective: To use alternative quantitation approaches to clarify the clinical implication of programmed cell death ligand 1 (PD-L1) in squamous cell carcinoma of the oral tongue (SCCOT).

Materials And Methods: Ventana SP263 immunohistochemistry assay and a multiplicative QuickScore method were applied to quantify PD-L1 in tumor and surrounding immune cells from 101 patients with SCCOT. Tumor-infiltrating immune cells were estimated from bulk tissue transcriptional profiles of 25 patients. Read More

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http://dx.doi.org/10.1111/odi.13414DOI Listing

Wilms' tumor 1 gene in hematopoietic malignancies: clinical implications and future directions.

Leuk Lymphoma 2020 May 13:1-9. Epub 2020 May 13.

Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, China.

The Wilms' tumor 1 () gene is an important regulatory molecule that plays a vital role in cell growth and development. Initially, knowledge of was mostly limited to Wilms' tumor. Over the past years, numerous studies have shown that is aberrant expressed or mutated in hematopoietic malignancies, including acute leukemia (AL), myelodysplastic syndrome (MDS) and chronic myelogenous leukemia (CML). Read More

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http://dx.doi.org/10.1080/10428194.2020.1762884DOI Listing

The COVID-19 pandemic: A rapid global response for children with cancer from SIOP, COG, SIOP-E, SIOP-PODC, IPSO, PROS, CCI, and St Jude Global.

Pediatr Blood Cancer 2020 07 13;67(7):e28409. Epub 2020 May 13.

International Society of Paediatric Oncology (SIOP), UCL Great Ormond Street Institute of Child Health, University College London, London, UK.

The COVID-19 pandemic is one of the most serious global challenges to delivering affordable and equitable treatment to children with cancer we have witnessed in the last few decades. This Special Report aims to summarize general principles for continuing multidisciplinary care during the SARS-CoV-2 (COVID-19) pandemic. With contributions from the leadership of the International Society for Pediatric Oncology (SIOP), Children's Oncology Group (COG), St Jude Global program, and Childhood Cancer International, we have sought to provide a framework for healthcare teams caring for children with cancer during the pandemic. Read More

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http://dx.doi.org/10.1002/pbc.28409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235469PMC