12,495 results match your criteria Wilms Tumor


Metastatic low-grade endometrial stromal sarcoma of uterus presenting as a primary pancreatic tumor: case presentation and literature review.

Diagn Pathol 2019 Apr 22;14(1):30. Epub 2019 Apr 22.

Department of Anatomical Pathology, Laboratory Medicine Program, University Health Network, Toronto General Hospital, 200 Elizabeth Street, 11th Floor, Eaton Wing, Toronto, Ontario, M5G 2C4, Canada.

Background: Metastatic tumors to the pancreas are uncommon, accounting for approximately 2% of pancreatic malignancies. The most common primary tumors to give rise to pancreatic metastases are carcinomas.

Case Presentation: A 50-year old female patient was investigated for a cause of abdominal discomfort. Read More

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http://dx.doi.org/10.1186/s13000-019-0807-3DOI Listing
April 2019
1 Read

Anaplastic sarcoma of the kidney: Case report and literature review.

Ci Ji Yi Xue Za Zhi 2019 Apr-Jun;31(2):129-132

Department of Pathology, Ditmanson Medical Foundation, Chiayi Christian Hospital, Chiayi, Taiwan.

We present a case of a 22-year-old female with gross hematuria for 1 month. A 9.5-cm tumor was found at her left kidney. Read More

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http://dx.doi.org/10.4103/tcmj.tcmj_194_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450149PMC

[Comparative evaluation of preoperation transcatheter arterial chemoembolization in children with advanced wilms tumor].

Zhonghua Yi Xue Za Zhi 2019 Apr;99(15):1147-1151

Department of Radiology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China.

To evaluate the therapeutic effect and prognosis of preoperative transcatheter arterial chemoembolization (TACE), transcatheter arterial chemoembolization (TAIC), preoperative intravenous chemotherapy for children with advanced stage nephroblastoma. From January 2007 to December 2018, according to different treatment protocols before surgery, children with nephroblastoma were divided into 3 groups, which were TACE group (44 cases), TAIC group (7 cases) and intravenous chemotherapy group (9 cases) in Children's Hospital, Zhejiang University School of Medicine. The imaging examination, treatment safety and long-term efficacy of these three groups before and after treatment were compared. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.15.006DOI Listing

Comparison of 3-Dimensional and Augmented Reality Kidney Models With Conventional Imaging Data in the Preoperative Assessment of Children With Wilms Tumors.

JAMA Netw Open 2019 Apr 5;2(4):e192633. Epub 2019 Apr 5.

Department of Pediatric Surgery, Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.

Importance: Nephron-sparing surgery can be considered in well-defined cases of unilateral and bilateral Wilms tumors, but the surgical procedure can be very challenging for the pediatric surgeon to perform.

Objective: To assess the added value of personalized 3-dimensional (3-D) kidney models derived from conventional imaging data to enhance preoperative surgical planning.

Design, Setting, And Participants: In a survey study, the conventional imaging data of 10 Dutch children with Wilms tumors were converted to 3-D prints and augmented reality (AR) holograms and a panel of pediatric oncology surgeons (n = 7) assessed the quality of the different imaging methods during preoperative evaluation. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2019.2633DOI Listing

SOX21-AS1 is associated with clinical stage and regulates cell proliferation in nephroblastoma.

Biosci Rep 2019 Apr 16. Epub 2019 Apr 16.

Linyi Central Hospital, Linyi, China.

LncRNA SOX21 antisense RNA 1 (SOX21-AS1) dysregulated in many types of human cancer, and functioned as tumor suppressor or promoter depending on tumor types. However, there was no report about the role of SOX21-AS1 in nephroblastoma. In present study, we firstly found SOX21-AS1 expression was elevated in nephroblastoma tissues and cell lines compared with adjacent normal tissues and normal human embryonic kidney cell line, respectively. Read More

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http://bioscirep.org/lookup/doi/10.1042/BSR20190602
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http://dx.doi.org/10.1042/BSR20190602DOI Listing
April 2019
2 Reads

Differential Expression of Wilms' Tumor Protein in Diffuse Intrinsic Pontine Glioma.

J Neuropathol Exp Neurol 2019 May;78(5):380-388

Children's National Health System, Center for Genetic Medicine Research, Washington, District of Columbia.

Diffuse intrinsic pontine gliomas (DIPGs) are deadly tumors comprising 10%-15% of all childhood CNS cancers. Standard treatment is considered palliative and prognosis is near universal mortality. DIPGs have been classified into genomic subtypes based on histone variants with the lysine to methionine mutation on position 27 of histone tails (K27M). Read More

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http://dx.doi.org/10.1093/jnen/nlz021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467196PMC
May 2019
2 Reads
3.797 Impact Factor

The Incidence and Durability of Compensatory Hypertrophy in Pediatric Patients with Solitary Kidneys.

Urology 2019 Apr 12. Epub 2019 Apr 12.

UCSF Benioff Children's Hospital, San Francisco, Department of Urology, Division of Pediatric Urology, USA. Electronic address:

Objective: To evaluate the incidence and durability of compensatory hypertrophy with solitary kidneys in the setting of those with multicystic dysplastic kidney or Wilms tumor status post nephrectomy.

Patients And Methods: We conducted a retrospective cohort study of patients with multicystic dysplastic kidneys (MCDK) and Wilms tumor (WT). MCDK patients were verified by sonographic findings prenatally. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00904295193034
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http://dx.doi.org/10.1016/j.urology.2019.04.003DOI Listing
April 2019
2 Reads

Antiangiogenic therapy for Wilms tumor in an adult and literature review.

Anticancer Drugs 2019 Apr 10. Epub 2019 Apr 10.

Departments of Oncology.

Wilms tumor is extremely rare in adults. There is no standard treatment for Wilms tumor in adults, and the therapy protocols are based on those used in children. Here, we report a case of Wilms tumor in a 24-year-old woman who was effectively treated with apatinib, a small-molecule inhibitor of vascular endothelial growth factor receptor-2. Read More

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http://dx.doi.org/10.1097/CAD.0000000000000792DOI Listing
April 2019
1 Read

[Congenital aniridia in children].

Rev Prat 2019 Jan;69(1):67-70

Service d'ophtalmologie, hôpital Necker Enfants-malades, AP-HP, centre de maladies rares OPHTARA, université Paris-Descartes, université Sorbonne-Paris-Cité, Paris, France. Unité CNRS FR3636, université Paris-Descartes, université Sorbonne-Paris-Cité, Paris, France. Coordonnateur du Centre OPHTARA maladies rares en Ophtalmologie, Centre Européen ERN EYE. Présidente du CMS Geniris et Aniridia Europe.

Congenital aniridia in children. Congenital aniridia is a genetic rare disease that affects the entire eyeball (pan-ocular disease). The disease is characterized by partial or complete absence of iris. Read More

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January 2019
1 Read

Quantitative proteomics identifies brain acid soluble protein 1 (BASP1) as a prognostic biomarker candidate in pancreatic cancer tissue.

EBioMedicine 2019 Apr 11. Epub 2019 Apr 11.

Department of Surgery, Clinical Sciences Lund, Lund University and Skåne University Hospital, Lund, Sweden. Electronic address:

Background: Pancreatic cancer is a heterogenous disease with a poor prognosis. This study aimed to discover and validate prognostic tissue biomarkers in pancreatic cancer using a mass spectrometry (MS) based proteomics approach.

Methods: Global protein sequencing of fresh frozen pancreatic cancer and healthy pancreas tissue samples was conducted by MS to discover potential protein biomarkers. Read More

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http://dx.doi.org/10.1016/j.ebiom.2019.04.008DOI Listing
April 2019
1 Read

Immune expression in children with Wilms tumor: a pilot study.

J Pediatr Urol 2019 Mar 20. Epub 2019 Mar 20.

Division of Surgical Sciences, Dept of Surgery, Duke University School of Medicine, Durham, NC, USA.

Background: Given improvements in multimodality therapy, survival among children with Wilms tumor (WT) exceeds 90%. However, 15% of children with favorable histology and 50% of children with anaplastic WT experience recurrence or progression. Of patients with advanced disease, only 50% survive to adulthood. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14775131193006
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http://dx.doi.org/10.1016/j.jpurol.2019.03.011DOI Listing
March 2019
2 Reads

INSM1 Expression in Peripheral Neuroblastic Tumors and Other Embryonal Neoplasms.

Pediatr Dev Pathol 2019 Apr 11:1093526619843725. Epub 2019 Apr 11.

1 Department of Pathology, Stanford University School of Medicine, Stanford, California.

Insulinoma-associated protein 1 (INSM1) is a transcription factor that functions in neuroepithelial tissue development and shows expression in neuroendocrine neoplasms. Given the role of INSM1 in controlling differentiation of the sympatho-adrenal lineage, we hypothesized that INSM1 expression would define a subset of neuroblastic tumors. This study aimed to characterize the immunohistochemical profile of INSM1 in a cohort of peripheral neuroblastic tumors and compare INSM1 expression in these tumors to that seen in other embryonal neoplasms, using both tissue microarrays and whole-slide histologic sections. Read More

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http://dx.doi.org/10.1177/1093526619843725DOI Listing
April 2019
1 Read

MAPK/ERK Signaling in Regulation of Renal Differentiation.

Int J Mol Sci 2019 Apr 10;20(7). Epub 2019 Apr 10.

Helsinki Institute of Life Science, University of Helsinki, FIN-00014 Helsinki, Finland.

Congenital anomalies of the kidney and urinary tract (CAKUT) are common birth defects derived from abnormalities in renal differentiation during embryogenesis. CAKUT is the major cause of end-stage renal disease and chronic kidney diseases in children, but its genetic causes remain largely unresolved. Here we discuss advances in the understanding of how mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) activity contributes to the regulation of ureteric bud branching morphogenesis, which dictates the final size, shape, and nephron number of the kidney. Read More

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http://dx.doi.org/10.3390/ijms20071779DOI Listing

Post therapy Wilms tumour or ectopic immature renal tissue: A pathologist's diagnostic dilemma.

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):266-269

Department of Pathology, IPGME and R, Kolkata, West Bengal, India.

Post chemotherapy Wilms Tumour (PCWT) is a diagnostic conundrum both for the clinician and the pathologist, in view of its morphological similarity with ectopic immature renal tissue (EIRT). However, due to their varying prognoses and different lines of management, it is important to distinguish between the two. Here, we discuss clinical presentation and pathology of a case of PCWT, arising in a horse shoe deformity of the kidney in a 5 year old girl. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_112_18DOI Listing

Prognostic Impact of WT-1 and Survivin Gene Expression in Acute Myeloid Leukemia Patients.

Clin Lab 2019 Apr;65(4)

Background: Wilms Tumor 1 (WT1) and Survivin genes are important leukemia-associated antigens (LAAs) in AML with potential prognostic impact.

Methods: We investigated WT1 and Survivin expression levels by RT-PCR in 61 AML patients in correlation with clinical characteristics and outcomes.

Results: WT1 was overexpressed in 45 patients (73. Read More

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http://www.clin-lab-publications.com/article/2973
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http://dx.doi.org/10.7754/Clin.Lab.2018.180329DOI Listing
April 2019
5 Reads

How do patient characteristics and anatomical features correlate to accuracy of organ dose reconstruction for Wilms' tumor radiation treatment plans when using a surrogate patient's CT scan?

J Radiol Prot 2019 Apr 9. Epub 2019 Apr 9.

Radiation Oncology, Amsterdam UMC, University of Amsterdam, Amsterdam, NETHERLANDS.

In retrospective radiation treatment (RT) dosimetry, a surrogate anatomy is often used for patients without 3D CT. To gain insight in what the crucial aspects in a surrogate anatomy are to enable accurate dose reconstruction, we investigated the relation of patient characteristics and internal anatomical features with deviations in reconstructed organ dose using surrogate patient's CT scans. Abdominal CT scans of 35 childhood cancer patients (age: 2. Read More

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http://dx.doi.org/10.1088/1361-6498/ab1796DOI Listing

, Not Maternal, Acquisition of Duplicated Orthologs in .

Int J Mol Sci 2019 Apr 5;20(7). Epub 2019 Apr 5.

Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture and College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China.

The highly conserved transcription factor Pax6 is involved in the development of the eyes, brain, and pancreas in vertebrates and invertebrates, whereas the additional expression pattern in other organs is still elusive. In this study, we cloned and characterized two homologs in blunt snout bream (), named and . The protein alignment and phylogenetic tree showed that Mapax6a and Mapax6b were highly conserved compared with their counterparts in other species. Read More

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http://dx.doi.org/10.3390/ijms20071710DOI Listing
April 2019
3 Reads
2.862 Impact Factor

Quantitative RT-PCR-based miRNA profiling of blastemal Wilms' tumors from formalin-fixed paraffin-embedded samples.

J Biotechnol 2019 Apr 5;298:11-15. Epub 2019 Apr 5.

Department of Human Genetics, Faculty of Medicine, University of Debrecen, 1 Egyetem tér, 4032, Debrecen, Hungary. Electronic address:

Blastemal Wilms' tumors are associated with poor chemo-responsiveness and an adverse prognosis. Our aim was to contribute to the miRNA profiling of the disease, while demonstrating the value of archived formalin-fixed, paraffin-embedded (FFPE) samples as miRNA sources. MiRNA was extracted from tumor and normal tissues of 8 patients diagnosed with blastemal Wilms' tumor in Hungary. Read More

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http://dx.doi.org/10.1016/j.jbiotec.2019.04.001DOI Listing

Dietary Turmeric Bisdemethoxycurcumin Suppresses Wilms' Tumor 1 and CD34 Protein Expressions in KG-1a Leukemic Stem Cells.

Nutr Cancer 2019 Apr 7:1-12. Epub 2019 Apr 7.

a Division of Clinical Microscopy, Department of Medical Technology, Faculty of Associated Medical Sciences , Chiang Mai University , Chiang Mai , Thailand.

Leukemic cells remaining in the body is the main problem for cancer patients, and these cells are called Leukemic Stem Cells (LSCs). Many studies have revealed that the overexpression of the Wilms' tumor 1 (WT1) protein is related to leukemogenesis. Curcuminoids (curcumin, demethoxycurcumin, and bisdemethoxycurcumin) from Thai turmeric (Curcuma longa Linn. Read More

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http://dx.doi.org/10.1080/01635581.2019.1598565DOI Listing
April 2019
1 Read

Late Recurrence of Wilms Tumor After 17 Years: A Case Report.

J Pediatr Hematol Oncol 2019 Apr 3. Epub 2019 Apr 3.

Departments of Pediatrics.

Wilms tumor is the most common renal malignancy in children. Most of Wilms tumor recurrences occur within 2 years of the first diagnosis. Relapse after 5 years after the first diagnosis is called "late recurrence" and is rare in Wilms tumor. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001473DOI Listing
April 2019
10 Reads

Comment on: "Indications and results of diagnostic biopsy in pediatric renal tumors: A retrospective analysis of 317 patients with critical review of SIOP guidelines".

Pediatr Blood Cancer 2019 Apr 2:e27746. Epub 2019 Apr 2.

University College London Great Ormond Street Institute of Child Health, London, UK.

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http://dx.doi.org/10.1002/pbc.27746DOI Listing
April 2019
1 Read

WARNING: G-401 and SK-NEP-1 cell lines are not Wilms tumor cell lines.

Pediatr Blood Cancer 2019 Mar 29:e27741. Epub 2019 Mar 29.

Molecular Bases of Genetic Risk and Genetic Testing Unit, Department of Research, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.

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http://dx.doi.org/10.1002/pbc.27741DOI Listing
March 2019
3 Reads

Fat, Cartilage, and Bone Metaplasia in Lungs of Cattle With Caudal Pleural Lesions and Subjacent Interstitial Fibrosis.

Vet Pathol 2019 Mar 27:300985819837719. Epub 2019 Mar 27.

1 Universidad Autónoma de Nuevo León, Posgrado Conjunto Agronomía-Veterinaria, Gral. Escobedo, Nuevo Leon, México.

The changes associated with condemned lungs in cattle with chronic pleural lesions of the caudal lobes were characterized by histology and immunohistochemistry (IHC). Fibroproliferative pleural lesions were microscopically confirmed. Occasionally, the pleural lesions also included adipose, chondroid, and osseous metaplasia that were covered by mesothelial cells, mostly in the absence of inflammation. Read More

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http://dx.doi.org/10.1177/0300985819837719DOI Listing
March 2019
1.869 Impact Factor

Rare clinical condition during Wilms' tumor treatment: Testicular metastasis.

Pediatr Int 2019 Mar;61(3):310-311

Department of Pediatric Oncology, Faculty of Medicine, Kocaeli University, Izmit, Kocaeli, Turkey.

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http://dx.doi.org/10.1111/ped.13769DOI Listing

Pediatric Renal Neoplasms:: MR Imaging-Based Practical Diagnostic Approach.

Magn Reson Imaging Clin N Am 2019 May;27(2):279-290

Department of Radiology, Seattle Children's, University of Washington, 4800 Sand Point Way Northeast, Seattle, WA 98105, USA.

Pediatric renal tumors may be malignant or benign. Wilms tumor, the most common malignant pediatric renal tumor, arises sporadically or with various syndromes. Renal cell carcinoma typically presents in older children. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10649689193000
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http://dx.doi.org/10.1016/j.mric.2019.01.006DOI Listing
May 2019
8 Reads

Serum α-l-fucosidase activities are significantly increased in patients with preeclampsia.

Prog Mol Biol Transl Sci 2019 8;162:349-362. Epub 2019 Mar 8.

Systems Biology and Medicine Center for Complex Diseases, Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:

Fucosylated glycans are essential molecules that facilitate signal transductions in several signal pathways and play important roles in development, inflammation, infection, and tumor metastasis. The fucosylated glycans are difficult to be developed into clinical biomarkers due to their complicated structures, but the decreased or increased activities of serum α-l-fucosidase, the lysosomal enzyme required for fucosylated glycan degradation, are diagnostic biomarker for patients with fucosidosis and hepatocellular carcinoma, respectively. However, the relationship between serum α-l-fucosidase activities and other human diseases is largely unknown. Read More

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http://dx.doi.org/10.1016/bs.pmbts.2018.12.008DOI Listing
March 2019
2 Reads

Glycated albumin level is significantly decreased in patients suffering nephrotic syndrome.

Prog Mol Biol Transl Sci 2019 6;162:307-319. Epub 2019 Mar 6.

Systems Biology and Medicine Center for Complex Diseases, Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:

Serum glycated albumin (GA) level is used along with that of glucose and glycated hemoglobin (HbA1c) as indicators of glycemic control for diabetic patients. Although serum GA levels are affected by blood glucose level, they are also influenced by serum albumin metabolism and other pathological conditions. However, a systematic comparison of the serum GA levels in different types of human diseases has not been reported. Read More

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http://dx.doi.org/10.1016/bs.pmbts.2019.01.006DOI Listing
March 2019
1 Read

Fasting blood glucose levels in patients with different types of diseases.

Prog Mol Biol Transl Sci 2019 6;162:277-292. Epub 2019 Mar 6.

Systems Biology and Medicine Center for Complex Diseases, Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:

Normal human physiology is dependent on a tight control of the fasting blood glucose (FBG) levels. The islets of pancreas maintains FBG levels within a narrow range of 4-6mmol/L by secreting various hormones, especially insulin and glucagon. However, the hormone secretions by the islets of pancreas are governed by a collective effort among pancreas-islet axis, brain-islet axis, liver-islet axis, gut-islet axis, and adipocyte/myocyte-islet axis. Read More

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http://dx.doi.org/10.1016/bs.pmbts.2019.01.004DOI Listing
March 2019
3 Reads

Serum AFP levels in patients suffering from 47 different types of cancers and noncancer diseases.

Prog Mol Biol Transl Sci 2019 6;162:199-212. Epub 2019 Mar 6.

Systems Biology and Medicine Center for Complex Diseases, Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:

Alpha-fetoprotein (AFP) is a glycoprotein and belongs to the gene family of serum albumins. The serum AFP levels were found to be elevated in the sera of liver cancer patients in 1964 and were subsequently developed and used as a liver cancer biomarker. However, elevated serum AFP levels have been observed in patients suffering from other cancer and noncancer diseases. Read More

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http://dx.doi.org/10.1016/bs.pmbts.2019.01.001DOI Listing
March 2019
1 Read

Measurable residual disease monitoring using Wilms tumor gene 1 expression in childhood acute myeloid leukemia based on child-specific reference values.

Pediatr Blood Cancer 2019 Jun 21;66(6):e27671. Epub 2019 Mar 21.

Department of Hematology, Aarhus University Hospital, Aarhus, Denmark.

Background: Measurable/minimal residual disease (MRD) monitoring can predict imminent hematological relapse in acute myeloid leukemia (AML). The majority of childhood AML patients do not harbor fusion genes or mutations applicable as MRD markers and overexpression of Wilms tumor gene 1 (WT1) may constitute a useful monitoring target. However, age-specific reference values in healthy hematopoiesis and standardization of WT1 assessment are prerequisites for clinical utility. Read More

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http://dx.doi.org/10.1002/pbc.27671DOI Listing
June 2019
1 Read

FXR1 expression domain in Wilms tumor.

J Pediatr Surg 2019 Feb 28. Epub 2019 Feb 28.

Vanderbilt University Medical Center, Department of Pediatric Surgery, Nashville, TN.

Background/purpose: Wilms tumor (WT) is the most common childhood kidney cancer globally. Our prior unbiased proteomic screen of WT disparities revealed increased expression of Fragile X-Related 1 (FXR1) in Kenyan specimens where survival is dismal. FXR1 is an RNA-binding protein that associates with poor outcomes in multiple adult cancers. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.02.030DOI Listing
February 2019
1 Read

Retroperitoneal Tumor: A Silent Trespasser - Role of Image-Guided Fine-Needle Aspiration Cytology with Histopathological Correlation in Early Diagnosis.

Acta Cytol 2019 Mar 20:1-9. Epub 2019 Mar 20.

Department of Pathology and Lab Medicine, All India Institute of Medical Sciences (AIIMS), Raipur, India.

Objective: Retroperitoneal lesions present a great diagnostic challenge. Here we analyze the spectrum of retroperitoneal lesions and the utility of cytohistopathological correlation in early diagnosis.

Study Design: This 7-year study was undertaken in 338 patients with a retroperitoneal mass (kidney/adrenal/ pancreas/retroperitoneal lymph node, or soft tissue origin). Read More

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http://dx.doi.org/10.1159/000497077DOI Listing
March 2019
5 Reads
1.562 Impact Factor

A case of metastatic Wilms' tumour with reversible distortion of mediastinal anatomy - a diagnostic challenge for the echocardiographer.

Images Paediatr Cardiol 2018 Jul-Dec;20(3):5-6

Department of Paediatrics and Child Health, Mater Dei Hospital, Malta.

Delineation and documentation of anatomy in the presence of significant mass pathology presents a diagnostic challenge. This often necessitates the implementation of more than one imaging modality in order to perform an adequate assessment. We present a three-year old boy with extensive distortion of mediastinal anatomy secondary to pleural metastases from a Wilms tumour. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360502PMC
March 2019
2 Reads

Identification of new Wilms tumour predisposition genes: an exome sequencing study.

Lancet Child Adolesc Health 2019 May 16;3(5):322-331. Epub 2019 Mar 16.

Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK; Cancer Genetics Unit, Royal Marsden NHS Foundation Trust, London, UK. Electronic address:

Background: Wilms tumour is the most common childhood renal cancer and is genetically heterogeneous. While several Wilms tumour predisposition genes have been identified, there is strong evidence that further predisposition genes are likely to exist. Our study aim was to identify new predisposition genes for Wilms tumour. Read More

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http://dx.doi.org/10.1016/S2352-4642(19)30018-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472290PMC
May 2019
2 Reads

Identifying new Wilms' tumour predisposition genes.

Lancet Child Adolesc Health 2019 May 16;3(5):285-287. Epub 2019 Mar 16.

Division of Haematology and Oncology, Department of Paediatrics, Hospital for Sick Children, Toronto, ON M5G-1X8, Canada.

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http://dx.doi.org/10.1016/S2352-4642(19)30064-1DOI Listing
May 2019
1 Read

What should we tackle next in acute myeloid leukemia? Wilms tumor gene 1 vaccine therapy would be a promising and versatile strategy for acute myeloid leukemia.

Expert Rev Hematol 2019 Apr 18;12(4):211-213. Epub 2019 Mar 18.

d Department of Cancer Immunology , Osaka University Graduate School of Medicine , Suita City, Osaka , Japan.

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http://dx.doi.org/10.1080/17474086.2019.1593824DOI Listing
April 2019
1 Read

Clinical Diagnosis Value of Chest X-Ray and Ultrasound in Recurrence in Patients With Favorable-Histology Wilms Tumor.

J Clin Oncol 2019 Mar 15:JCO1801886. Epub 2019 Mar 15.

1 Lulu Xie, MD; Baihui Liu, MD; and Kuiran Dong, PhD, Children's Hospital of Fudan University, Shanghai, People's Republic of China.

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http://dx.doi.org/10.1200/JCO.18.01886DOI Listing
March 2019
2 Reads

Immunotherapeutic Targeting of GPC3 in Pediatric Solid Embryonal Tumors.

Front Oncol 2019 26;9:108. Epub 2019 Feb 26.

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, United States.

Glypican 3 (GPC3) is a heparan sulfate proteoglycan and cell surface oncofetal protein which is highly expressed on a variety of pediatric solid embryonal tumors including the majority of hepatoblastomas, Wilms tumors, rhabdoid tumors, certain germ cell tumor subtypes, and a minority of rhabdomyosarcomas. Via both its core protein and heparan sulfate side chains, GPC3 activates the canonical Wnt/β-catenin pathway, which is frequently overexpressed in these malignancies. Loss of function mutations in lead to Simpson-Golabi-Behmel Syndrome, an X-linked overgrowth condition with a predisposition to GPC3-expressing cancers including hepatoblastoma and Wilms tumor. Read More

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http://dx.doi.org/10.3389/fonc.2019.00108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401603PMC
February 2019
4 Reads

Upfront Nephrectomy Versus Preoperative Chemotherapy In Wilm's Tumour.

J Ayub Med Coll Abbottabad 2019 Jan-Mar;31(1):104-107

Children's Hospital, Pakistan Institute of Medical Sciences, Islamabad, Pakistan.

Background: Wilms tumour is the most common renal tumour in paediatric age group. This study was done to compare the two approaches used for treatment, namely upfront nephrectomy versus pre-operative chemotherapy.. Read More

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March 2019
1 Read

PAI-1 and protein C as early markers of veno-occlusive disease in patients treated for Wilms tumor.

Pediatr Blood Cancer 2019 Mar 13:e27695. Epub 2019 Mar 13.

Hematology Oncology Division, Department of Mother's and Child's Health, University of Padova, Padova, Italy.

Background: Hepatic veno-occlusive (VOD) disease has been described in hematopoietic stem cell transplantation (HSCT), solid tumors, and acute lymphoblastic leukemia. The incidence of VOD in Wilms tumor (WT) ranges from 1.2% to 8%. Read More

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http://dx.doi.org/10.1002/pbc.27695DOI Listing
March 2019
2 Reads

The cell tube block technique and an immunohistochemistry panel including Wilms tumor 1 to assist in diagnosing cavitary effusions in dogs and cats.

Vet Clin Pathol 2019 Mar 13;48(1):50-60. Epub 2019 Mar 13.

DIMEVET Dipartimento di Medicina Veterinaria, Università degli Studi di Milano, Milan, Italy.

Background: Cell blocks and immunohistochemistry (IHC) are increasingly recognized as being complementary tools for cytologic diagnostics, especially for neoplastic diseases.

Objectives: The study aimed to evaluate the utility of cell tube block (CTB) IHC for refining the diagnosis of effusions in dogs and cats.

Methods: Cavitary effusions (n = 25) from dogs and cats classified by cytology as reactive, neoplastic, borderline (suspicious of neoplasia), and chylous were studied. Read More

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http://dx.doi.org/10.1111/vcp.12709DOI Listing
March 2019
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miR-140-5p alleviates the aggressive progression of Wilms' tumor through directly targeting gene.

Cancer Manag Res 2019 19;11:1641-1651. Epub 2019 Feb 19.

Department of Neurology, Henan Kaifeng Children's Hospital, Kaifeng, Henan, China,

Background And Objective: Although many miRNAs are identified to be deregulated and play vital roles in the progression of Wilms' tumor (WT), there are still a large number of miRNAs are waiting for us to explore. The purpose of the present study is to investigate the different expressing profiles of miRNAs in WT tissues and the adjacent normal tissues, and probe the effects and mechanism of a certain miRNA among the different expressing miRNAs.

Methods: miRNA microarray was recruited to assess the differently expressed miRNAs in WT tissues and normal tissues, which was further verified by RT-PCR. Read More

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http://dx.doi.org/10.2147/CMAR.S177508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389000PMC
February 2019
7 Reads

, A Prognosis-Related Enhancer RNA in Squamous Cell Carcinoma of the Head and Neck.

Cancers (Basel) 2019 Mar 11;11(3). Epub 2019 Mar 11.

Department of Medical Biosciences/Pathology, Umeå University, 90185 Umeå, Sweden.

A growing number of long non-coding RNAs (lncRNAs) have been linked to squamous cell carcinoma of the head and neck (SCCHN). A subclass of lncRNAs, termed enhancer RNAs (eRNAs), are derived from enhancer regions and could contribute to enhancer function. In this study, we developed an integrated data analysis approach to identify key eRNAs in SCCHN. Read More

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https://www.mdpi.com/2072-6694/11/3/347
Publisher Site
http://dx.doi.org/10.3390/cancers11030347DOI Listing
March 2019
5 Reads

Association of and gene polymorphisms with Wilms tumor risk: a four-center case-control study.

Aging (Albany NY) 2019 Mar;11(5):1551-1563

Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China.

Wilms tumor is a type of pediatric solid tumor that arises partly due to somatic and germline mutations. Single-nucleotide polymorphisms (SNPs) in the gene reportedly modify the risk for several types of human malignancies. We conducted a multicenter study to investigate whether gene variants predispose individuals to Wilms tumor. Read More

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http://www.aging-us.com/article/101855/text
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http://dx.doi.org/10.18632/aging.101855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428095PMC
March 2019
8 Reads

Haploinsufficiency of the brain-derived neurotrophic factor gene is associated with reduced pain sensitivity.

Pain 2019 05;160(5):1070-1081

Pediatrics and Developmental Neuropsychiatry Branch, National Institute of Mental Health (NIH), Bethesda, MD, United States.

Rare pain-insensitive individuals offer unique insights into how pain circuits function and have led to the development of new strategies for pain control. We investigated pain sensitivity in humans with WAGR (Wilms tumor, aniridia, genitourinary anomaly, and range of intellectual disabilities) syndrome, who have variably sized heterozygous deletion of the 11p13 region. The deletion region can be inclusive or exclusive of the brain-derived neurotrophic factor (BDNF) gene, a crucial trophic factor for nociceptive afferents. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476691PMC
May 2019
1 Read

Curcumin suppresses wilms' tumor metastasis by inhibiting RECK methylation.

Biomed Pharmacother 2019 Mar 15;111:1204-1212. Epub 2019 Jan 15.

Department of Pediatric Urology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China. Electronic address:

Wilms' tumor (WT) is the most common kidney tumor of children. The transformation suppressor gene RECK, which codes membrane-anchored glycoprotein, frequently downregulates multiple matrix metalloproteinases in tumors. And curcumin, which is a polyphenlic compound separated from turmeric, has antitumor effects on various cancers. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.12.111DOI Listing
March 2019
3 Reads

Risk of selected childhood cancers and parental employment in painting and printing industries: A register-based case‒control study in Denmark 1968-2015.

Scand J Work Environ Health 2019 Mar 6. Epub 2019 Mar 6.

The Danish Cancer Society Research Center, Strandboulevarden 49, DK-2100 Copenhagen Ø, Denmark.

Objectives Parental exposures and offspring's risk of cancer have been studied with inconsistent results. We investigated parental employment in painting and printing industries and risk of childhood leukemia, central nervous system (CNS) cancers, and prenatal cancers (acute lymphoblastic leukemia, Wilms tumor, medulloblastoma, neuroblastoma, retinoblastoma, and hepatoblastoma). Methods Using Danish registries, children aged ≤19 years diagnosed from 1968-2015 with leukemia (N=1999), CNS cancers (N=1111) or prenatal cancers (N=2704) were linked to parents and their employment history one year before birth to birth for fathers, and one year before birth to one year after for mothers. Read More

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http://dx.doi.org/10.5271/sjweh.3811DOI Listing
March 2019
7 Reads

G-quadruplex forming region within WT1 promoter is selectively targeted by daunorubicin and mitoxantrone: A possible mechanism for anti-leukemic effect of drugs.

J Biosci 2019 Mar;44(1)

Department of Molecular and Cell Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar CP: 47416-95447, Iran.

Wilms tumor 1 has long been overexpressed in acute myeloid leukemia and has a prognostic value in its diagnosis. Lately, the formation of G-quadruplexes in oncogenic promoters like has been widely investigated since stabilization of these structures leads to transcriptional inhibition of the oncogene. Daunorubicin and mitoxantrone considered as crucial components of almost all standard acute myeloid leukemia induction regimens. Read More

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March 2019
3 Reads
2.064 Impact Factor