235 results match your criteria Whole-Bowel Irrigation

Short-Term Interferential Transabdominal Electrical Stimulation Did Not Change Oral-Rectal Transit Time in Piglets.

Neuromodulation 2018 Oct 2;21(7):669-675. Epub 2018 Mar 2.

Surgical Research Group, Murdoch Children's Research Institute, Parkville, VIC, Australia.

Background: Transcutaneous electrical stimulation (TES) using interferential current (IFC) is a new therapeutic treatment for constipation. Clinical studies show that TES-IFC for 3-6 months improves colonic transit, but it is not clear if short-term stimulation affects transit or the effect requires longer to develop. The aim of this study was to determine if TES-IFC for only four days affects oral-rectal transit time in healthy pigs. Read More

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October 2018

[Treating poisoning; how do you choose the best type of gastrointestinal decontamination?]

Ned Tijdschr Geneeskd 2018;162:D1574

St Antonius Ziekenhuis, afd. Klinische Farmacie, Nieuwegein.

- A new guideline: 'Intoxication: initial approach in the hospital' will be published this year. This guideline sets out the latest insights on gastrointestinal decontamination in intoxication; the advice is summarized in a flowchart.- The advice is to generally administer activated charcoal, unless there are indications that the toxin will not bind to activated charcoal or that the amount of toxin that the patient has ingested is too great; in these cases gastric lavage can be considered. Read More

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January 2018
2 Reads

Pediatric Orbeez Ingestions Reported to Texas Poison Centers.

Pediatr Emerg Care 2017 Jul 11. Epub 2017 Jul 11.

From the *Department of State Health Services, Austin, TX.

Objectives: There is concern that ingestion of superabsorbent polymer toys, which can absorb large amounts of fluid and increase greatly in volume, may pose a risk if swallowed by children.The intent of this study was to characterize pediatric Orbeez ingestions reported to a statewide poison center system.

Methods: Cases were Orbeez ingestions among patients 19 years or younger reported to Texas poison centers during January 2011 to June 2016. Read More

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July 2017
10 Reads

Clinical, endoscopic and pathological characteristics of colorectal polyps in elderly patients: Single-center experience.

Mol Clin Oncol 2017 Jul 1;7(1):81-87. Epub 2017 Jun 1.

Department of Gastroenterology and Key Laboratory for Molecular Diagnosis of Hubei, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, P.R. China.

Increasing age is a risk factor for the development of colorectal adenomas and advanced adenomas. However, few studies have been published on the features of colorectal polyps in the elderly. The present study aimed to investigate the clinical, enteroscopic and pathological characteristics of colorectal polyps in Chinese elderly patients in a single center (The Central Hospital of Wuhan, Hubei, China). Read More

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July 2017
26 Reads

Intentional ingestion of elemental mercury requiring multi-step decontamination and prophylactic appendectomy: a case report and treatment proposal.

Clin Toxicol (Phila) 2018 Jan 26;56(1):69-73. Epub 2017 Jun 26.

c Department of Internal Medicine, Gastroenterology Unit , Ospedale dell'Angelo and Ospedale SS Giovanni e Paolo , Venice , Italy.

Background: Ingestion of elemental mercury (Hg0) is considered non-toxic. After massive ingestion, local intestinal complications may develop: retention within appendix is quite frequent but treatment is debated. We describe a case of intentional ingestion of Hg0 requiring multi-step decontamination and prophylactic appendectomy. Read More

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January 2018
17 Reads
3.120 Impact Factor

Chemical Hand Warmer Packet Ingestion: A Case of Elemental Iron Exposure.

Wilderness Environ Med 2017 Sep 17;28(3):246-248. Epub 2017 Jun 17.

Department of Emergency Medicine, Lehigh Valley Hospital/USF Morsani College of Medicine, Allentown, Pennsylvania. Electronic address:

For individuals who work outdoors in the winter or play winter sports, chemical hand warmers are becoming increasingly more commonplace because of their convenience and effectiveness. A 32-year-old woman with a history of chronic pain and bipolar disorder presented to the emergency department complaining of a "warm sensation" in her mouth and epigastrium after reportedly ingesting the partial contents of a chemical hand warmer packet containing between 5 and 8 g of elemental iron. She had been complaining of abdominal pain for approximately 1 month and was prescribed unknown antibiotics the previous day. Read More

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September 2017
5 Reads

Toll-like receptor 4 is critical for the development of resection-associated hepatic steatosis.

J Pediatr Surg 2017 Jun 16;52(6):1014-1019. Epub 2017 Mar 16.

Division of Pediatric Surgery, Department of Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; St. Louis Children's Hospital, St. Louis, MO, USA. Electronic address:

Background: A significant number of children with short bowel syndrome experience intestinal failure-associated liver disease. We recently demonstrated accelerated hepatic steatosis after 50% small bowel resection (SBR) in mice. Since SBR is associated with alterations in the gut microbiome, the purpose of this study was to determine whether TLR4 signaling is critical to the development of resection-associated hepatic steatosis. Read More

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June 2017
4 Reads

Effects of prophylactic incisional gastropexy on markers of gastric motility in dogs as determined by use of a novel wireless motility device.

Am J Vet Res 2017 Jan;78(1):100-106

OBJECTIVE To evaluate effects of laparoscopic-assisted incisional gastropexy (LAIG) on gastric motility in dogs by use of a wireless motility device (WMD). ANIMALS 10 healthy client-owned large or giant-breed dogs. PROCEDURES 10 dogs owned by clients interested in prophylactic LAIG were enrolled. Read More

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January 2017

Lubiprostone Accelerates Intestinal Transit and Alleviates Small Intestinal Bacterial Overgrowth in Patients With Chronic Constipation.

Am J Med Sci 2016 09 24;352(3):231-8. Epub 2016 May 24.

Department of Internal Medicine, Texas Tech University Health Sciences Center, El Paso, Texas.

Background: Lubiprostone is an effective treatment for chronic constipation (CC). The mechanism of action of lubiprostone is through increasing fluid secretion and lubrication of the intestinal lumen. The effects of lubiprostone on gastrointestinal transit and small intestinal bacterial overgrowth (SIBO) have not been adequately explored. Read More

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September 2016
19 Reads

The Influence of Polyethylene Glycol Solution on the Dissolution Rate of Sustained Release Morphine.

J Med Toxicol 2016 12 13;12(4):391-395. Epub 2016 Jun 13.

Institute of Analytical Chemistry and Food Chemistry, Graz University of Technology, Graz, Austria.

Introduction: Whole bowel irrigation (WBI) is a management option for overdose of medications poorly adsorbed to activated charcoal, with modified release properties, or for body packers. Polyethylene glycol (PEG) is a mixture of ethylene oxide polymers of varying molecular weight. PEG with an average molecular weight of 3350 g/mol is used for WBI. Read More

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December 2016
9 Reads

A Rare Case of an Early Postoperative Obstructive Ileus in a Young Female Patient due to a Residual Trichobezoar Mass.

Case Rep Surg 2016 11;2016:4121969. Epub 2016 Apr 11.

Surgical Department, Airedale General Hospital, West Yorkshire BD20 6TD, UK.

Trichobezoar is a rare cause of small bowel obstruction, whereby a mass forms most commonly in the stomach and duodenum of young females, from ingestion of hair, a condition known as trichophagia. We present a case of recurrent small bowel obstruction due to a residual hair mass that was removed surgically in a young female patient who had a laparotomy and gastrotomy for removal of a large gastric trichobezoar just two weeks prior to the current admission. This case illustrates the importance of a thorough inspection of the whole bowel to ensure that no residual bezoars remain after surgery. Read More

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The effects of camicinal, a novel motilin agonist, on gastro-esophageal function in healthy humans-a randomized placebo controlled trial.

Neurogastroenterol Motil 2015 Nov 8;27(11):1629-37. Epub 2015 Sep 8.

GlaxoSmithKline, Research Triangle Park, NC, USA.

Background: A proportion of patients with foregut dysmotility fail to respond to standard interventions. Motilin agonists may be beneficial in this group. We aimed to determine the effect of camicinal, a novel motilin agonist, on gastrointestinal physiology in healthy volunteers. Read More

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November 2015
16 Reads

Calcium channel antagonist and beta-blocker overdose: antidotes and adjunct therapies.

Br J Clin Pharmacol 2016 Mar 30;81(3):453-61. Epub 2015 Oct 30.

Monash Health Clinical Toxicology and Addiction Medicine Service, Monash Health, Dandenong Hospital, David Street, Dandenong, VIC, 3175, Australia.

Management of cardiovascular instability resulting from calcium channel antagonist (CCB) or beta-adrenergic receptor antagonist (BB) poisoning follows similar principles. Significant myocardial depression, bradycardia and hypotension result in both cases. CCBs can also produce vasodilatory shock. Read More

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March 2016
17 Reads

Hepatocyte Growth Factor and MET Support Mouse Enteric Nervous System Development, the Peristaltic Response, and Intestinal Epithelial Proliferation in Response to Injury.

J Neurosci 2015 Aug;35(33):11543-58

Departments of Pediatrics, Developmental Regenerative and Stem Cell Biology, and Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania and The Children's Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania 19104,

Unlabelled: Factors providing trophic support to diverse enteric neuron subtypes remain poorly understood. We tested the hypothesis that hepatocyte growth factor (HGF) and the HGF receptor MET might support some types of enteric neurons. HGF and MET are expressed in fetal and adult enteric nervous system. Read More

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August 2015
3 Reads

Two Year Old With Water Bead Ingestion.

Pediatr Emerg Care 2015 Aug;31(8):605-7

From the Children's Mercy Hospital and Clinics, Kansas City, MO.

Foreign body ingestion is a common pediatric complaint. Two case reports describe intestinal obstruction in children from an ingestion of a single superabsorbent water ball, requiring surgical removal. We describe nonsurgical management of an asymptomatic child who ingested approximately 100 superabsorbent water beads. Read More

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August 2015
5 Reads

Percutaneous Aspiration Embolectomy Using Guiding Catheter for the Superior Mesenteric Artery Embolism.

Korean J Radiol 2015 Jul-Aug;16(4):736-43. Epub 2015 Jul 1.

Department of Radiology, Seoul National University College of Medicine, Institute of Radiation Medicine, Seoul National University Medical Research Center, and Clinical Research Institute, Seoul National University Hospital, Seoul 110-744, Korea.

Objective: To evaluate the technical feasibility and clinical outcome of percutaneous aspiration embolectomy for embolic occlusion of the superior mesenteric artery (SMA).

Materials And Methods: Between January 2010 and December 2013, 9 patients with embolic occlusion of the SMA were treated by percutaneous aspiration embolectomy in 2 academic teaching hospitals. The aspiration embolectomy procedure was performed with the 6-Fr and 7-Fr guiding catheter. Read More

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February 2016
9 Reads

The features of intestinal tuberculosis by contrast-enhanced ultrasound.

Jpn J Radiol 2015 Sep 15;33(9):577-84. Epub 2015 Jul 15.

Department of Ultrasonography, Hangzhou Red Cross Hospital, No 208, Huangcheng East Road, Hangzhou, 310003, China.

Purpose: To examine the imaging characteristics of intestinal tuberculosis by conventional ultrasound and contrast-enhanced ultrasound (CEUS).

Materials And Methods: Characteristics of the conventional and contrast-enhanced ultrasound images of 31 patients with intestinal tuberculosis confirmed by surgery were retrospectively examined. CEUS was used to evaluate the pattern of the bowel wall enhancement. Read More

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September 2015
5 Reads

What is the main target: a clearer colon with a sennoside-based regime, or adequate bowel cleansing before colonoscopy with a PEG-EL-based regime?

Turk J Med Sci 2015 ;45(2):404-8

Background/aim: Even though polyethylene glycol-electrolyte lavage (PEG-EL)-based regimes have become the gold standard in recent years, to finish drinking 4 L of PEG-EL solution can be difficult. The quality of sennoside-based bowel-cleansing regimes used in Turkey has been known for some time. Therefore, we aimed to investigate the efficacy of both bowel-cleansing regimes. Read More

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July 2015
11 Reads
0.840 Impact Factor

Examining the whole bowel, double balloon enteroscopy: Indications, diagnostic yield and complications.

World J Gastrointest Endosc 2015 Mar;7(3):247-52

Fatih Saygili, Erkin Oztas, Department of Gastroenterology, Turkiye Yuksek Ihtisas Education and Research Hospital, 06040 Ankara, Turkıye.

Double balloon enteroscopy (DBE) is an advanced type of endoscopic procedure which brings the advantage of reaching the whole small bowel using anterograde or the retrograde route. This procedure is both diagnostic and interventional for a variety of small intestinal diseases, such as vascular lesions, tumors, polyps and involvement of inflammatory bowel diseases. Main indication is the diagnosis and treatment of mid-gastrointestinal bleeding according to the recent published data all over the world. Read More

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March 2015
18 Reads

Conventional ultrasound and contrast-enhanced ultrasound in evaluating the severity of Crohn's disease.

Int J Clin Exp Med 2015 15;8(1):123-34. Epub 2015 Jan 15.

Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tenth People's Hospital of Tongji University Shanghai, China.

Objective: To evaluate the value of conventional ultrasound and contrast-enhanced ultrasound (CEUS) in determining the severity of active Crohn's disease.

Methods: Thirty-seven patients who were considered to be in active period of Crohn's disease were included. Conventional ultrasound was employed to measure the thicknesses of interior, exterior and the whole bowel walls. Read More

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March 2015
38 Reads

[Iron intoxication--poisoning with easily accessible medicines].

Lakartidningen 2014 Sep 17-23;111(38):1576-7

A 20-year-old woman was found semiconscious on the floor in a pool of black diarrhea with an empty 100 jar of ferrous sulphate beside her (100 mg Fe2+/tablet), 160 mg/kg. She was brought to the hospital an estimated 4 hours after ingestion and presented with irritability and a fluctuating CNS depression. Her blood pressure was 190/85 mmHg and pulse 130 bpm. Read More

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February 2015
5 Reads

Symptomatic Exposures Among California Inmates 2011-2013.

J Med Toxicol 2015 Sep;11(3):309-16

Department of Internal Medicine, Tulane University Medical Center, New Orleans, LA, USA,

Prisoners have a high prevalence of substance misuse and abuse, but few studies have examined symptomatic exposures among incarcerated populations. We sought to further characterize the nature of these exposures among this population using the California Poison Control System data. Keyword searches identified inmate cases in 2011-2013 for patients 20+ years old exposed to a single substance and taken to hospital from jail, prison, or police custody. Read More

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September 2015
5 Reads

Position paper update: whole bowel irrigation for gastrointestinal decontamination of overdose patients.

Clin Toxicol (Phila) 2015 Jan 16;53(1):5-12. Epub 2014 Dec 16.

European Association of Poisons Centres and Clinical Toxicologists , Brussels , Belgium.

Context: A position paper on the use of whole bowel irrigation (WBI) was first published in 1997 by the American Academy of Clinical Toxicology (AACT) and the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) and updated in 2004. The aims of this paper are to briefly summarize the content of the 2004 Position Paper and to present any new data and recommendations.

Methods: A systematic review of the literature from January 2003 to February 28, 2013 was conducted using multiple online databases for articles concerning WBI for gastrointestinal decontamination. Read More

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January 2015
11 Reads

[Is it radical enough? Transanal endoscopic microsurgery for the treatment of rectal neoplasia -- clinicopathological viewpoint].

Magy Seb 2014 Dec;67(6):329-33

Semmelweis Egyetem I. Sz. Sebészeti Klinika 1082 Budapest Üllői út 78.

The transanal endoscopic microsurgery (TEM) provides lower relapse and complication rate for the the surgical treatment of the neoplasms of the middle and lower third of the rectum in selected cases. Hence, it can be an alternative method of the conventional approaches, if it does not compromise oncological radicality. The TEM procedure has been started at the 1st Department of Surgery, Semmelweis University in the fall of 2013. Read More

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December 2014

Metastatic squamous cell carcinoma from hand skin causing small bowel obstruction: an unusual case presentation.

World J Surg Oncol 2014 May 28;12:166. Epub 2014 May 28.

Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, China.

The small bowel rarely suffers from metastatic tumors from outside the abdomen. Small bowel obstructions caused by the metastatic spread of squamous cell carcinoma (SCC) of the hand to the intestines are even rarer. A 71-year-old man with intermittent abdominal distension and pain for 4 months was diagnosed with partial bowel obstruction. Read More

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May 2014
5 Reads

Extended release potassium salts overdose and endoscopic removal of a pharmacobezoar: A case report.

Toxicol Rep 2014 22;1:209-213. Epub 2014 May 22.

Residente de Toxicología Hospital Angeles Lomas, Vialidad de la Barranca No. 14, Colonia Valle de las Palmas, Huixquilucan, Estado de México CP 52787, Mexico.

Background: Reported cases of potassium overdoses have shown that this condition could generate several morbidities, mainly related to cardiac dysrhythmias even with fatal outcomes in some cases. Potassium salts in extended release tablets could form pharmacobezoars if a large amount is ingested. In relation to the above, when the patient has a pharmacobezoar, clinical findings may be delayed and may persist. Read More

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May 2014
4 Reads

Free jejunal flap transfer for pharyngoesophageal reconstruction in patients with intestinal malrotation: two case reports.

Microsurgery 2014 Oct 24;34(7):582-5. Epub 2014 Mar 24.

Department of Plastic and Reconstructive Surgery, Hamamatsu University School of Medicine, Shizuoka, Japan.

Intestinal malrotation results from failure of intestinal rotation and fixation during fetal life. We report two cases of esophageal reconstruction with free jejunal flaps following total laryngopharyngectomy of hypopharyngeal and cervical esophageal carcinoma in which intestinal malrotation was detected during the jejunal flap harvesting. In both cases, the ligament of Treitz was absent, and the laparotomy incision was thus extended to identify the jejunum. Read More

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October 2014
8 Reads

Endoscopic removal of pharmacobezoar in case of intentional potassium overdose.

J Emerg Med 2014 Mar 7;46(3):351-4. Epub 2013 Oct 7.

Department of Emergency Medicine, Carilion Roanoke Memorial Hospital, Roanoke, Virginia; Department of Pharmacy, Carilion Roanoke Memorial Hospital, Roanoke, Virginia.

Background: Hyperkalemia is a potentially life-threatening electrolyte abnormality commonly seen in the emergency department (ED). Intentional overdose of potassium supplements is an uncommon occurrence.

Objective: This case illustrates a novel approach to treatment of pharmacobezoar with esophagogastroduodenoscopy (EGD) and demonstrates its effectiveness in the setting of extended-release potassium chloride overdose. Read More

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March 2014
4 Reads

Factors associated with severe effects following acute glufosinate poisoning.

Clin Toxicol (Phila) 2013 Nov 18;51(9):846-9. Epub 2013 Sep 18.

Department of Emergency Medicine, Iwate Medical University, School of Medicine , Morioka, Iwate , Japan.

Context: In acute glufosinate poisoning, sudden respiratory arrest and convulsion can occur after a latent period of 4-60 h. There is still no factor that accurately predicts the occurrence of these symptoms.

Objective: To elucidate the predictors of severe effects following acute glufosinate poisoning. Read More

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November 2013
2 Reads

Mechanical bowel preparation and prophylactic antibiotic administration in colorectal surgery: a survey of the current status in Korea.

Ann Coloproctol 2013 Aug 29;29(4):160-6. Epub 2013 Aug 29.

Department of Surgery, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea.

Purpose: The usefulness of mechanical bowel preparation (MBP) in colon surgery was recently challenged by many multicenter clinical trials and meta-analyses. The objectives of this study were to investigate current national opinions about MBP and prophylactic antibiotics (PA) and to provide preliminary data for developing future Korean guidelines for MBP and PA administration in colorectal surgery.

Methods: A questionnaire was mailed to 129 colorectal specialists. Read More

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August 2013
17 Reads

Lithium poisoning: the value of early digestive tract decontamination.

Clin Toxicol (Phila) 2013 May 9;51(4):243-8. Epub 2013 Apr 9.

CHU Angers, Pôle Médecines Intensives et spécialisées, Centre antipoison et Toxicovigilance, Angers, France.

Objective: The objective of this study was to evaluate the effects of early digestive tract decontamination on the severity of acute-on-chronic lithium poisoning (acute poisoning in patients under long-term therapy).

Materials And Methods: This was an observational and retrospective study of acute-on-chronic lithium overdoses recorded by the Angers Poisons and Toxicovigilance Centre between February 2006 and September 2010. The cases of overdose were divided into two groups: those undergoing early decontamination (by sodium polystyrene sulphonate and/or whole bowel irrigation) and those in whom decontamination was delayed (> 12 h) or not performed. Read More

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May 2013
2 Reads

Position paper update: ipecac syrup for gastrointestinal decontamination.

Clin Toxicol (Phila) 2013 Mar 13;51(3):134-9. Epub 2013 Feb 13.

European Association of Poison Centres and Clinical Toxicologists.

Context: An update of the first position paper on ipecac syrup from 1997 was published by the American Academy of Clinical Toxicology and the European Association of Poison Centres and Clinical Toxicologists in 2004. The aims of this paper are to briefly summarize the content of the 2004 Position Paper and to present any new data.

Methods: A systematic review of the literature from the year 2003 forward. Read More

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March 2013
2 Reads

A clinicopathological study of serotonin of sigmoid colon mucosa in association with chronic symptoms in uncomplicated diverticulosis.

Int J Colorectal Dis 2012 Dec 29;27(12):1597-605. Epub 2012 Jun 29.

Department of Colorectal Surgery, Kings College Hospital, London, UK.

Introduction: Neurotransmitter imbalance is hypothesised as a pathogenetic mechanism in several bowel conditions. We previously reported increased 5-HT in the sigmoid mucosa of colon resected for complicated diverticular disease (DD). We aimed to identify if abnormal 5-HT expression is associated with symptoms of uncomplicated DD. Read More

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December 2012
1 Read

A retrospective review of whole bowel irrigation in pediatric patients.

Clin Toxicol (Phila) 2012 Jun;50(5):414-7

University of California-San Diego, Toxicology, San Diego, CA 92103, USA.

Background: Traditionally whole bowel irrigation (WBI) has been advocated for ingestions involving substances not bound with activated charcoal as well as extended release and enteric coated medications. Other than isolated case reports, little exists in the literature regarding the use of WBI in poisoned pediatric patients. The purpose of this study is to better understand the use of WBI in pediatric patients. Read More

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June 2012
3 Reads

Lipid therapy for the treatment of a refractory amitriptyline overdose.

CJEM 2012 May;14(3):193-7

Departmens of Medicine, Dalhousie University, Halifax, NS.

Tricyclic antidepressant (TCA) overdose is a leading cause of death among intentional overdoses. Intravenous lipid emulsion therapy is an emerging antidote for local anesthetic toxicity, and there is animal evidence that lipid therapy may be efficacious in TCA overdose. Furthermore, case reports in humans have described the use of lipid therapy to reverse the toxicity of other lipophilic drugs. Read More

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May 2012
7 Reads

Fecal transplantation, through colonoscopy, is effective therapy for recurrent Clostridium difficile infection.

Gastroenterology 2012 Mar 7;142(3):490-6. Epub 2011 Dec 7.

Department of Infectious Diseases, Helsinki University Central Hospital, Helsinki, Finland.

Background & Aims: Treatment of recurrent Clostridium difficile infection (CDI) with antibiotics leads to recurrences in up to 50% of patients. We investigated the efficacy of fecal transplantation in treatment of recurrent CDI.

Methods: We reviewed records from 70 patients with recurrent CDI who had undergone fecal transplantation. Read More

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March 2012
5 Reads

Decontamination and enhanced elimination in sustained-release potassium chloride poisoning.

Naren Gunja

Emerg Med Australas 2011 Dec;23(6):769-72

New South Wales Poisons, The Children's Hospital at Westmead, New South Wales, Australia.

Potassium chloride poisoning can be potentially life-threatening, particularly in massive ingestions of sustained-release preparations. Profound hyperkalaemia, developing over several hours, can lead to cardiac arrhythmias and death. This case series reports three episodes of sustained-release potassium chloride poisoning in two individuals requiring whole bowel irrigation or haemodialysis. Read More

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December 2011
3 Reads

Gastrointestinal decontamination in the acutely poisoned patient.

Int J Emerg Med 2011 Oct 12;4:65. Epub 2011 Oct 12.

Department of Internal Medicine, School of Medicine, University of California, Davis, Sacramento, California, USA.

Objective: To define the role of gastrointestinal (GI) decontamination of the poisoned patient.

Data Sources: A computer-based PubMed/MEDLINE search of the literature on GI decontamination in the poisoned patient with cross referencing of sources.

Study Selection And Data Extraction: Clinical, animal and in vitro studies were reviewed for clinical relevance to GI decontamination of the poisoned patient. Read More

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October 2011
5 Reads

Medical management of motility disorders in patients with intestinal failure: a focus on necrotizing enterocolitis, gastroschisis, and intestinal atresia.

J Pediatr Surg 2011 Aug;46(8):1618-30

Division of Pediatric Surgery, Stollery Children's Hospital, University of Alberta Hospital, Edmonton, Alberta, Canada.

Background: Intestinal failure (IF) is the dependence upon parenteral nutrition to maintain minimal energy requirements for growth and development. It may occur secondary to a loss of bowel length, disorders of motility, or both. Short bowel syndrome (SBS) is a malabsorptive state resulting from surgical resection, congenital defect, or diseases associated with loss of absorptive surface area. Read More

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August 2011
2 Reads

Management of an oral ingestion of transdermal fentanyl patches: a case report and literature review.

Case Rep Med 2011 12;2011:495938. Epub 2011 May 12.

Department of Pharmacy Services, University Health System, 4502 Medical Drive, San Antonio, TX 78229, USA.

Purpose. Fentanyl is available as a transdermal system for the treatment of chronic pain in opioid-tolerant patients; however, it carries a black box warning due to both the potency of the product and the potential for abuse. In this report, we describe a case of transbuccal and gastrointestinal ingestion of fentanyl patches and the management of such ingestion. Read More

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July 2011
13 Reads

The effect of decontamination procedures on the pharmacodynamics of venlafaxine in overdose.

Br J Clin Pharmacol 2011 Jul;72(1):125-32

School of Pharmacy, University of Otago, Dunedin, New Zealand.

Aims: To investigate the relationship between decontamination procedures and seizure events caused by venlafaxine overdose and to estimate the time at which 90% of patients would have had their first seizure in the presence and absence of decontamination.

Methods: Data were collected from 319 patients who took an overdose of venlafaxine on 436 occasions. Seizures occurred on 24 of 436 occasions (5%). Read More

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July 2011
5 Reads

Application of distractive forces to the small intestine: defining safe limits.

J Surg Res 2010 Oct 21;163(2):169-75. Epub 2010 Apr 21.

Section of Pediatric Surgery, Department of Surgery, C.S. Mott Children's Hospital, University of Michigan, Ann Arbor, Michigan 48109-0245, USA.

Background: Distraction enterogenesis is a novel method for increasing small bowel length by the application of linearly directed forces. However, the magnitude of distractive forces that human and animal small bowel can safely withstand is unknown.

Methods: Acute ex vivo force-displacement curves for human (n = 5) and pig (n = 6) small intestine (with and without mesentery) were made by applying increasing amounts of distractive forces to bowel immersed in normal saline (39°C). Read More

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October 2010

Evaluation of potential factors predicting attainment of full gavage feedings in preterm infants.

Neonatology 2011 30;99(1):38-44. Epub 2010 Jun 30.

Department of Pediatrics, Children's Nutrition Research Center, Houston, Tex 77030-2600, USA. rshulman @ bcm.tmc.edu

Background: The clinical measures of gastric residuals and abdominal distention are often used to guide feeding in preterm infants, but there are few data demonstrating their usefulness. Similarly, techniques are now available to investigate gastrointestinal (GI) function noninvasively and safely, but their ability to predict attainment of full gavage feedings and/or feeding volume in preterm infants is unclear.

Objective: We sought to determine prospectively the potential relationships of attainment of full gavage feedings and feeding volume with clinical measures and noninvasive GI tests. Read More

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April 2011
2 Reads

Drugs and pharmaceuticals: management of intoxication and antidotes.

Silas W Smith

EXS 2010 ;100:397-460

New York City Poison Control Center, New York University School of Medicine, New York, USA.

The treatment of patients poisoned with drugs and pharmaceuticals can be quite challenging. Diverse exposure circumstances, varied clinical presentations, unique patient-specific factors, and inconsistent diagnostic and therapeutic infrastructure support, coupled with relatively few definitive antidotes, may complicate evaluation and management. The historical approach to poisoned patients (patient arousal, toxin elimination, and toxin identification) has given way to rigorous attention to the fundamental aspects of basic life support--airway management, oxygenation and ventilation, circulatory competence, thermoregulation, and substrate availability. Read More

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April 2010
4 Reads

[Seizure and non-cardiogenic pulmonary edema after intoxication].

Internist (Berl) 2010 Apr;51(4):528-32

Medizinische Klinik, Universitätsspital Basel, Basel, Schweiz.

We report a case of severe intoxication with extended-release verapamil. In addition to cardiovascular toxicities with hypotension, atrioventricular block and bradycardia, the patient suffered from grand-mal seizure and pulmonary edema 13 and 48 hours respectively, after ingestion of 4.8 g of extended-release verapamil. Read More

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April 2010
3 Reads

Clinical management of cocaine body packers: the Hillingdon experience.

Can J Surg 2009 Oct;52(5):417-21

Department of Surgery, Charing Cross Hospital, Fulham Palace Road, London, UK.

Background: International smuggling of cocaine by internal concealment is a serious and growing problem. People who engage in this practice are commonly referred to as body packers or mules. The most serious risks associated with body packing include intestinal obstruction and death from cocaine intoxication. Read More

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October 2009
6 Reads

Sclerosing encapsulating peritonitis (abdominal cocoon) associated with liver cirrhosis and diffuse large B-cell lymphoma: autopsy case.

Pathol Int 2009 Sep;59(9):681-6

Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

A case of sclerosing encapsulating peritonitis (SEP) associated with liver cirrhosis (LC) and complicated by diffuse large B-cell lymphoma (DLBCL) is reported herein. A 49-year-old Japanese man had undergone peritoneo-venous shunt against refractory ascites due to hepatitis C virus-positive uncompensated LC for 2 years. After he received a diagnosis of DLBCL of the left neck lymph node 3 months before his death, palliative care was given because of his poor general condition. Read More

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September 2009
2 Reads

The effect of decontamination procedures on the pharmacokinetics of venlafaxine in overdose.

Clin Pharmacol Ther 2009 Oct 15;86(4):403-10. Epub 2009 Jul 15.

School of Pharmacy, University of Otago, Dunedin, New Zealand.

The aim of this work was to investigate the pharmacokinetics (PK) of venlafaxine in overdose and the effects of single-dose activated charcoal (SDAC) and whole-bowel irrigation (WBI), alone or in combination, as methods of decontamination. The data included 339 concentration-time points from 76 venlafaxine overdose events (median dose 2,625 (150-13,500 mg)); 69 were slow-release doses. SDAC, WBI, a combination of both, or no decontamination were administered to patients as decided by the treating clinician. Read More

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October 2009
3 Reads