333 results match your criteria Whole Bowel Irrigation


First use of whole-genome sequencing to investigate a cluster of Yersinia enterocolitica, Liverpool, United Kingdom, 2017.

J Med Microbiol 2018 Dec 16;67(12):1747-1752. Epub 2018 Oct 16.

4​North West Health Protection Team, Public Health England, Liverpool, UK.

Purpose: In May 2017 we were notified of a cluster of Yersinia enterocolitica-positive isolates from Liverpool. The purpose of this work was to investigate this cluster of cases and find a possible common source. We combined epidemiological information with whole-genome sequencing (WGS) results, which indicated that these cases were unlikely to be from the same source. Read More

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http://dx.doi.org/10.1099/jmm.0.000856DOI Listing
December 2018

[Treating poisoning; how do you choose the best type of gastrointestinal decontamination?]

Ned Tijdschr Geneeskd 2018;162:D1574

St Antonius Ziekenhuis, afd. Klinische Farmacie, Nieuwegein.

- A new guideline: 'Intoxication: initial approach in the hospital' will be published this year. This guideline sets out the latest insights on gastrointestinal decontamination in intoxication; the advice is summarized in a flowchart.- The advice is to generally administer activated charcoal, unless there are indications that the toxin will not bind to activated charcoal or that the amount of toxin that the patient has ingested is too great; in these cases gastric lavage can be considered. Read More

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December 2018
3 Reads

Pediatric Orbeez Ingestions Reported to Texas Poison Centers.

Pediatr Emerg Care 2017 Jul 11. Epub 2017 Jul 11.

From the *Department of State Health Services, Austin, TX.

Objectives: There is concern that ingestion of superabsorbent polymer toys, which can absorb large amounts of fluid and increase greatly in volume, may pose a risk if swallowed by children.The intent of this study was to characterize pediatric Orbeez ingestions reported to a statewide poison center system.

Methods: Cases were Orbeez ingestions among patients 19 years or younger reported to Texas poison centers during January 2011 to June 2016. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001227DOI Listing
July 2017
12 Reads

Intentional ingestion of elemental mercury requiring multi-step decontamination and prophylactic appendectomy: a case report and treatment proposal.

Clin Toxicol (Phila) 2018 Jan 26;56(1):69-73. Epub 2017 Jun 26.

c Department of Internal Medicine, Gastroenterology Unit , Ospedale dell'Angelo and Ospedale SS Giovanni e Paolo , Venice , Italy.

Background: Ingestion of elemental mercury (Hg0) is considered non-toxic. After massive ingestion, local intestinal complications may develop: retention within appendix is quite frequent but treatment is debated. We describe a case of intentional ingestion of Hg0 requiring multi-step decontamination and prophylactic appendectomy. Read More

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http://dx.doi.org/10.1080/15563650.2017.1338346DOI Listing
January 2018
21 Reads
3.120 Impact Factor

Chemical Hand Warmer Packet Ingestion: A Case of Elemental Iron Exposure.

Wilderness Environ Med 2017 Sep 17;28(3):246-248. Epub 2017 Jun 17.

Department of Emergency Medicine, Lehigh Valley Hospital/USF Morsani College of Medicine, Allentown, Pennsylvania. Electronic address:

For individuals who work outdoors in the winter or play winter sports, chemical hand warmers are becoming increasingly more commonplace because of their convenience and effectiveness. A 32-year-old woman with a history of chronic pain and bipolar disorder presented to the emergency department complaining of a "warm sensation" in her mouth and epigastrium after reportedly ingesting the partial contents of a chemical hand warmer packet containing between 5 and 8 g of elemental iron. She had been complaining of abdominal pain for approximately 1 month and was prescribed unknown antibiotics the previous day. Read More

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http://dx.doi.org/10.1016/j.wem.2017.04.006DOI Listing
September 2017
6 Reads

The Influence of Polyethylene Glycol Solution on the Dissolution Rate of Sustained Release Morphine.

J Med Toxicol 2016 12 13;12(4):391-395. Epub 2016 Jun 13.

Institute of Analytical Chemistry and Food Chemistry, Graz University of Technology, Graz, Austria.

Introduction: Whole bowel irrigation (WBI) is a management option for overdose of medications poorly adsorbed to activated charcoal, with modified release properties, or for body packers. Polyethylene glycol (PEG) is a mixture of ethylene oxide polymers of varying molecular weight. PEG with an average molecular weight of 3350 g/mol is used for WBI. Read More

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http://dx.doi.org/10.1007/s13181-016-0561-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135674PMC
December 2016
9 Reads

Calcium channel antagonist and beta-blocker overdose: antidotes and adjunct therapies.

Br J Clin Pharmacol 2016 Mar 30;81(3):453-61. Epub 2015 Oct 30.

Monash Health Clinical Toxicology and Addiction Medicine Service, Monash Health, Dandenong Hospital, David Street, Dandenong, VIC, 3175, Australia.

Management of cardiovascular instability resulting from calcium channel antagonist (CCB) or beta-adrenergic receptor antagonist (BB) poisoning follows similar principles. Significant myocardial depression, bradycardia and hypotension result in both cases. CCBs can also produce vasodilatory shock. Read More

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http://dx.doi.org/10.1111/bcp.12763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767195PMC
March 2016
19 Reads

Two Year Old With Water Bead Ingestion.

Pediatr Emerg Care 2015 Aug;31(8):605-7

From the Children's Mercy Hospital and Clinics, Kansas City, MO.

Foreign body ingestion is a common pediatric complaint. Two case reports describe intestinal obstruction in children from an ingestion of a single superabsorbent water ball, requiring surgical removal. We describe nonsurgical management of an asymptomatic child who ingested approximately 100 superabsorbent water beads. Read More

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http://pdfs.journals.lww.com/pec-online/2015/08000/Two_Year_
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/PEC.0000000000000520DOI Listing
August 2015
5 Reads

What is the main target: a clearer colon with a sennoside-based regime, or adequate bowel cleansing before colonoscopy with a PEG-EL-based regime?

Turk J Med Sci 2015 ;45(2):404-8

Background/aim: Even though polyethylene glycol-electrolyte lavage (PEG-EL)-based regimes have become the gold standard in recent years, to finish drinking 4 L of PEG-EL solution can be difficult. The quality of sennoside-based bowel-cleansing regimes used in Turkey has been known for some time. Therefore, we aimed to investigate the efficacy of both bowel-cleansing regimes. Read More

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http://journals.tubitak.gov.tr/medical/issues/sag-15-45-2/sa
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July 2015
11 Reads
0.841 Impact Factor

Meconium ileus in newborns with cystic fibrosis - results of treatment in the group of patients operated on in the years 2000-2014.

Dev Period Med 2015 Jan-Mar;19(1):32-40

Clinical Department of Children's and Adolescents' Surgery, Institute of Mother and Child, Kasprzaka Street 17a, 01-211 Warsaw, Poland, tel. (+48 22) 32-77-107, e-mail:

Aim: Evaluation of diagnostic and treatment procedures in children with cystic fibrosis (CF) operated on because of meconium ileus (MI).

Material And Methods: The authors retrospectively reviewed the documentation of 10 CF newborn patients operated on in the years 2000-2014 because of MI. In prenatal ultrasound (US) examinations, suspicion of bowel abnormalities was raised in 2 cases, even though all the 10 mothers had a minimum of 3 US examinations during pregnancy. Read More

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June 2015
14 Reads

[Clinical study on the treatment of acute paraquat poisoning with sequential whole gastric and bowel irrigation].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2015 Mar;33(3):213-5

Liaochen People's Hospital, Shandong Province, Liaochen 252000, China.

Objective: To explore the clinical efficacy of early application of sequential gastrointestinal lavage in patients with acute paraquat poisoning by analyzing the clinical data of 97 patients.

Methods: A total of 97 eligible patients with acute paraquat poisoning were divided into conventional treatment group (n = 48) and sequential treatment group (n = 49). The conventional treatment group received routine gastric lavage with water. Read More

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March 2015
3 Reads

Role of signal transducer and activator of transcription 1 in murine allergen-induced airway remodeling and exacerbation by carbon nanotubes.

Am J Respir Cell Mol Biol 2015 Nov;53(5):625-36

Environmental and Molecular Toxicology Program, Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina.

Asthma is characterized by a T helper type 2 phenotype and by chronic allergen-induced airway inflammation (AAI). Environmental exposure to air pollution ultrafine particles (i.e. Read More

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http://dx.doi.org/10.1165/rcmb.2014-0221OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742949PMC
November 2015
16 Reads

[Iron intoxication--poisoning with easily accessible medicines].

Lakartidningen 2014 Sep 17-23;111(38):1576-7

A 20-year-old woman was found semiconscious on the floor in a pool of black diarrhea with an empty 100 jar of ferrous sulphate beside her (100 mg Fe2+/tablet), 160 mg/kg. She was brought to the hospital an estimated 4 hours after ingestion and presented with irritability and a fluctuating CNS depression. Her blood pressure was 190/85 mmHg and pulse 130 bpm. Read More

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February 2015
5 Reads

Symptomatic Exposures Among California Inmates 2011-2013.

J Med Toxicol 2015 Sep;11(3):309-16

Department of Internal Medicine, Tulane University Medical Center, New Orleans, LA, USA,

Prisoners have a high prevalence of substance misuse and abuse, but few studies have examined symptomatic exposures among incarcerated populations. We sought to further characterize the nature of these exposures among this population using the California Poison Control System data. Keyword searches identified inmate cases in 2011-2013 for patients 20+ years old exposed to a single substance and taken to hospital from jail, prison, or police custody. Read More

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http://link.springer.com/10.1007/s13181-014-0456-6
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http://dx.doi.org/10.1007/s13181-014-0456-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547960PMC
September 2015
5 Reads

Position paper update: whole bowel irrigation for gastrointestinal decontamination of overdose patients.

Clin Toxicol (Phila) 2015 Jan 16;53(1):5-12. Epub 2014 Dec 16.

European Association of Poisons Centres and Clinical Toxicologists , Brussels , Belgium.

Context: A position paper on the use of whole bowel irrigation (WBI) was first published in 1997 by the American Academy of Clinical Toxicology (AACT) and the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) and updated in 2004. The aims of this paper are to briefly summarize the content of the 2004 Position Paper and to present any new data and recommendations.

Methods: A systematic review of the literature from January 2003 to February 28, 2013 was conducted using multiple online databases for articles concerning WBI for gastrointestinal decontamination. Read More

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http://dx.doi.org/10.3109/15563650.2014.989326DOI Listing
January 2015
12 Reads

Split-dose vs same-day reduced-volume polyethylene glycol electrolyte lavage solution for morning colonoscopy.

World J Gastroenterol 2014 Oct;20(39):14488-94

Wah-Kheong Chan, Sanjiv Mahadeva, Khean-Lee Goh, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.

Aim: To compare same-day whole-dose vs split-dose of 2-litre polyethylene glycol electrolyte lavage solution (PEG-ELS) plus bisacodyl for colon cleansing for morning colonoscopy.

Methods: Consecutive adult patients undergoing morning colonoscopy were allocated into two groups i.e. Read More

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http://dx.doi.org/10.3748/wjg.v20.i39.14488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202378PMC
October 2014
9 Reads

Rectal effluent as a research tool.

Dig Dis Sci 2015 Jan 2;60(1):24-31. Epub 2014 Sep 2.

University of South Alabama Mitchell Cancer Institute, Mobile, AL, USA,

Studies of localized secretions are generally superior to those of blood because they contain higher concentrations of molecules specific to the organ of interest. A common method used to analyze localized secretions is lavage. The flow of fluid over the lining of a cavity picks up both cells and soluble factors, and the effluent can be collected for study. Read More

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http://dx.doi.org/10.1007/s10620-014-3330-0DOI Listing
January 2015
6 Reads

Optimal bowel cleansing for colonoscopy: split the dose! A series of meta-analyses of controlled studies.

Gastrointest Endosc 2014 Oct 19;80(4):566-576.e2. Epub 2014 Jul 19.

Gastroenterology and Endoscopy Unit, L. Curto Hospital, Polla (Salerno), Italy. Electronic address:

Background: Colonoscopy is considered the criterion standard for detecting colorectal cancer; adequate preparation is crucial for an effective colonoscopy, but definitive data on the optimal preparation are lacking.

Objective: Our aim was to assess the efficacy of split-dose versus non-split-dose preparations, the rate of adequate preparation according to type and dose of laxatives, the role of "runway time" (the interval time between the last drink of purgative and the beginning of colonoscopy), and to evaluate compliance as an additive risk factor for colon cleansing.

Design: A series of meta-analyses of controlled studies. Read More

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http://dx.doi.org/10.1016/j.gie.2014.05.320DOI Listing
October 2014
11 Reads

Extended release potassium salts overdose and endoscopic removal of a pharmacobezoar: A case report.

Toxicol Rep 2014 22;1:209-213. Epub 2014 May 22.

Residente de Toxicología Hospital Angeles Lomas, Vialidad de la Barranca No. 14, Colonia Valle de las Palmas, Huixquilucan, Estado de México CP 52787, Mexico.

Background: Reported cases of potassium overdoses have shown that this condition could generate several morbidities, mainly related to cardiac dysrhythmias even with fatal outcomes in some cases. Potassium salts in extended release tablets could form pharmacobezoars if a large amount is ingested. In relation to the above, when the patient has a pharmacobezoar, clinical findings may be delayed and may persist. Read More

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http://dx.doi.org/10.1016/j.toxrep.2014.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598358PMC
May 2014
5 Reads

Inhibition of intestinal epithelial apoptosis improves survival in a murine model of radiation combined injury.

PLoS One 2013 28;8(10):e77203. Epub 2013 Oct 28.

Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, United States of America.

World conditions place large populations at risk from ionizing radiation (IR) from detonation of dirty bombs or nuclear devices. In a subgroup of patients, ionizing radiation exposure would be followed by a secondary infection. The effects of radiation combined injury are potentially more lethal than either insult in isolation. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0077203PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810465PMC
August 2014
4 Reads

Endoscopic removal of pharmacobezoar in case of intentional potassium overdose.

J Emerg Med 2014 Mar 7;46(3):351-4. Epub 2013 Oct 7.

Department of Emergency Medicine, Carilion Roanoke Memorial Hospital, Roanoke, Virginia; Department of Pharmacy, Carilion Roanoke Memorial Hospital, Roanoke, Virginia.

Background: Hyperkalemia is a potentially life-threatening electrolyte abnormality commonly seen in the emergency department (ED). Intentional overdose of potassium supplements is an uncommon occurrence.

Objective: This case illustrates a novel approach to treatment of pharmacobezoar with esophagogastroduodenoscopy (EGD) and demonstrates its effectiveness in the setting of extended-release potassium chloride overdose. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07364679130094
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http://dx.doi.org/10.1016/j.jemermed.2013.08.031DOI Listing
March 2014
4 Reads

Factors associated with severe effects following acute glufosinate poisoning.

Clin Toxicol (Phila) 2013 Nov 18;51(9):846-9. Epub 2013 Sep 18.

Department of Emergency Medicine, Iwate Medical University, School of Medicine , Morioka, Iwate , Japan.

Context: In acute glufosinate poisoning, sudden respiratory arrest and convulsion can occur after a latent period of 4-60 h. There is still no factor that accurately predicts the occurrence of these symptoms.

Objective: To elucidate the predictors of severe effects following acute glufosinate poisoning. Read More

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http://dx.doi.org/10.3109/15563650.2013.841180DOI Listing
November 2013
2 Reads

Mechanical bowel preparation and prophylactic antibiotic administration in colorectal surgery: a survey of the current status in Korea.

Ann Coloproctol 2013 Aug 29;29(4):160-6. Epub 2013 Aug 29.

Department of Surgery, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea.

Purpose: The usefulness of mechanical bowel preparation (MBP) in colon surgery was recently challenged by many multicenter clinical trials and meta-analyses. The objectives of this study were to investigate current national opinions about MBP and prophylactic antibiotics (PA) and to provide preliminary data for developing future Korean guidelines for MBP and PA administration in colorectal surgery.

Methods: A questionnaire was mailed to 129 colorectal specialists. Read More

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http://dx.doi.org/10.3393/ac.2013.29.4.160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767866PMC
August 2013
19 Reads

Adding pineapple juice to a polyethylene glycol-based bowel cleansing regime improved the quality of colon cleaning.

Ann Nutr Metab 2013 14;63(1-2):83-7. Epub 2013 Aug 14.

Department of Gastroenterology, Dıskapı Yıldırım Beyazıt Education and Research Hospital, Ankara, Turkey.

Background/aims: An unsuccessful colonoscopy procedure is often related to inadequate bowel cleansing. It is difficult for patients to finish the whole 4 liters of polyethylene glycol-electrolyte lavage (PEG-EL) because of its salty taste and the large quantity. Pineapple juice has been shown to be an effective agent in the dissolution of undigested food in the stomach. Read More

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http://dx.doi.org/10.1159/000354094DOI Listing
April 2014
11 Reads
1 Citation
2.620 Impact Factor

Lithium poisoning: the value of early digestive tract decontamination.

Clin Toxicol (Phila) 2013 May 9;51(4):243-8. Epub 2013 Apr 9.

CHU Angers, Pôle Médecines Intensives et spécialisées, Centre antipoison et Toxicovigilance, Angers, France.

Objective: The objective of this study was to evaluate the effects of early digestive tract decontamination on the severity of acute-on-chronic lithium poisoning (acute poisoning in patients under long-term therapy).

Materials And Methods: This was an observational and retrospective study of acute-on-chronic lithium overdoses recorded by the Angers Poisons and Toxicovigilance Centre between February 2006 and September 2010. The cases of overdose were divided into two groups: those undergoing early decontamination (by sodium polystyrene sulphonate and/or whole bowel irrigation) and those in whom decontamination was delayed (> 12 h) or not performed. Read More

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http://dx.doi.org/10.3109/15563650.2013.782409DOI Listing
May 2013
2 Reads

The effect of whole gut irrigation on contractile responses of guinea pig gallbladder, ileum, and tissue cholecystokinin levels.

Eur J Pediatr Surg 2014 Apr 4;24(2):168-73. Epub 2013 Mar 4.

Department of Pediatric Surgery, Ankara University School of Medicine, Ankara, Turkey.

Aim: An experimental study was performed to evaluate the effect of whole gut irrigation (WGI) solutions on contractile responses of the gallbladder and ileum and also on tissue cholecystokinin (CCK) levels.

Materials And Methods: Thirty guinea pigs were enrolled into five groups including control group (CG) and WGI group (saline physiologic [SP], Ringer lactated [RL], polyethylene glycol [PEG], and dibasic sodium phosphate [DNP]). After median laparotomy, the distal esophagus was ligated and SP, PEG, RL, and DNP infusions (2 mL/kg/min) were performed via gastric catheter until rectal discharge became clear in WGI groups. Read More

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http://dx.doi.org/10.1055/s-0033-1337115DOI Listing
April 2014
4 Reads

Position paper update: ipecac syrup for gastrointestinal decontamination.

Clin Toxicol (Phila) 2013 Mar 13;51(3):134-9. Epub 2013 Feb 13.

European Association of Poison Centres and Clinical Toxicologists.

Context: An update of the first position paper on ipecac syrup from 1997 was published by the American Academy of Clinical Toxicology and the European Association of Poison Centres and Clinical Toxicologists in 2004. The aims of this paper are to briefly summarize the content of the 2004 Position Paper and to present any new data.

Methods: A systematic review of the literature from the year 2003 forward. Read More

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http://dx.doi.org/10.3109/15563650.2013.770153DOI Listing
March 2013
2 Reads

A retrospective review of whole bowel irrigation in pediatric patients.

Clin Toxicol (Phila) 2012 Jun;50(5):414-7

University of California-San Diego, Toxicology, San Diego, CA 92103, USA.

Background: Traditionally whole bowel irrigation (WBI) has been advocated for ingestions involving substances not bound with activated charcoal as well as extended release and enteric coated medications. Other than isolated case reports, little exists in the literature regarding the use of WBI in poisoned pediatric patients. The purpose of this study is to better understand the use of WBI in pediatric patients. Read More

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http://dx.doi.org/10.3109/15563650.2012.679277DOI Listing
June 2012
3 Reads

Lipid therapy for the treatment of a refractory amitriptyline overdose.

CJEM 2012 May;14(3):193-7

Departmens of Medicine, Dalhousie University, Halifax, NS.

Tricyclic antidepressant (TCA) overdose is a leading cause of death among intentional overdoses. Intravenous lipid emulsion therapy is an emerging antidote for local anesthetic toxicity, and there is animal evidence that lipid therapy may be efficacious in TCA overdose. Furthermore, case reports in humans have described the use of lipid therapy to reverse the toxicity of other lipophilic drugs. Read More

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May 2012
7 Reads

Fecal transplantation, through colonoscopy, is effective therapy for recurrent Clostridium difficile infection.

Gastroenterology 2012 Mar 7;142(3):490-6. Epub 2011 Dec 7.

Department of Infectious Diseases, Helsinki University Central Hospital, Helsinki, Finland.

Background & Aims: Treatment of recurrent Clostridium difficile infection (CDI) with antibiotics leads to recurrences in up to 50% of patients. We investigated the efficacy of fecal transplantation in treatment of recurrent CDI.

Methods: We reviewed records from 70 patients with recurrent CDI who had undergone fecal transplantation. Read More

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http://dx.doi.org/10.1053/j.gastro.2011.11.037DOI Listing
March 2012
5 Reads

Decontamination and enhanced elimination in sustained-release potassium chloride poisoning.

Authors:
Naren Gunja

Emerg Med Australas 2011 Dec;23(6):769-72

New South Wales Poisons, The Children's Hospital at Westmead, New South Wales, Australia.

Potassium chloride poisoning can be potentially life-threatening, particularly in massive ingestions of sustained-release preparations. Profound hyperkalaemia, developing over several hours, can lead to cardiac arrhythmias and death. This case series reports three episodes of sustained-release potassium chloride poisoning in two individuals requiring whole bowel irrigation or haemodialysis. Read More

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http://dx.doi.org/10.1111/j.1742-6723.2011.01469.xDOI Listing
December 2011
3 Reads

Gastrointestinal decontamination in the acutely poisoned patient.

Int J Emerg Med 2011 Oct 12;4:65. Epub 2011 Oct 12.

Department of Internal Medicine, School of Medicine, University of California, Davis, Sacramento, California, USA.

Objective: To define the role of gastrointestinal (GI) decontamination of the poisoned patient.

Data Sources: A computer-based PubMed/MEDLINE search of the literature on GI decontamination in the poisoned patient with cross referencing of sources.

Study Selection And Data Extraction: Clinical, animal and in vitro studies were reviewed for clinical relevance to GI decontamination of the poisoned patient. Read More

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http://dx.doi.org/10.1186/1865-1380-4-65DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207879PMC
October 2011
5 Reads

Preparation before colonoscopy: a randomized controlled trial comparing different regimes.

Eur J Gastroenterol Hepatol 2011 Oct;23(10):897-902

Internal Medicine and Gastroenterology, Atrium Medical Center Parkstad, Heerlen, The Netherlands.

Background And Aim: A good bowel preparation is essential for optimal visualization of the large intestine. Several preparations with a difference in composition and volume are available. We compared five methods for bowel cleansing quality and patients' acceptability. Read More

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http://dx.doi.org/10.1097/MEG.0b013e32834a3444DOI Listing
October 2011
9 Reads

Management of an oral ingestion of transdermal fentanyl patches: a case report and literature review.

Case Rep Med 2011 12;2011:495938. Epub 2011 May 12.

Department of Pharmacy Services, University Health System, 4502 Medical Drive, San Antonio, TX 78229, USA.

Purpose. Fentanyl is available as a transdermal system for the treatment of chronic pain in opioid-tolerant patients; however, it carries a black box warning due to both the potency of the product and the potential for abuse. In this report, we describe a case of transbuccal and gastrointestinal ingestion of fentanyl patches and the management of such ingestion. Read More

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http://dx.doi.org/10.1155/2011/495938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099212PMC
July 2011
13 Reads

The effect of decontamination procedures on the pharmacodynamics of venlafaxine in overdose.

Br J Clin Pharmacol 2011 Jul;72(1):125-32

School of Pharmacy, University of Otago, Dunedin, New Zealand.

Aims: To investigate the relationship between decontamination procedures and seizure events caused by venlafaxine overdose and to estimate the time at which 90% of patients would have had their first seizure in the presence and absence of decontamination.

Methods: Data were collected from 319 patients who took an overdose of venlafaxine on 436 occasions. Seizures occurred on 24 of 436 occasions (5%). Read More

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http://dx.doi.org/10.1111/j.1365-2125.2011.03934.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141194PMC
July 2011
5 Reads

Anti-inflammatory effects of ethanolic extract from Lagerstroemia indica on airway inflammation in mice.

J Ethnopharmacol 2011 Jul 18;136(3):422-7. Epub 2010 Jun 18.

Department of Biomedical Laboratory Science, School of Medicine, Eulji University, Yeuongdu-dong, Jung-gu, Daejeon, Republic of Korea.

Aim Of The Study: In the present study, we investigated whether the Lagerstroemia indica Linn (LI) extract has an anti-inflammatory effect on lung inflammation in ovalbumin-induced asthmatic mice.

Materials And Methods: The LI extract was obtained from dried and powdered whole plants of LI using 80% ethanol. ELISA was performed to evaluate cytokine concentration. Read More

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http://dx.doi.org/10.1016/j.jep.2010.05.066DOI Listing
July 2011
6 Reads

Drugs and pharmaceuticals: management of intoxication and antidotes.

Authors:
Silas W Smith

EXS 2010 ;100:397-460

New York City Poison Control Center, New York University School of Medicine, New York, USA.

The treatment of patients poisoned with drugs and pharmaceuticals can be quite challenging. Diverse exposure circumstances, varied clinical presentations, unique patient-specific factors, and inconsistent diagnostic and therapeutic infrastructure support, coupled with relatively few definitive antidotes, may complicate evaluation and management. The historical approach to poisoned patients (patient arousal, toxin elimination, and toxin identification) has given way to rigorous attention to the fundamental aspects of basic life support--airway management, oxygenation and ventilation, circulatory competence, thermoregulation, and substrate availability. Read More

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April 2010
4 Reads

Clinical management of cocaine body packers: the Hillingdon experience.

Can J Surg 2009 Oct;52(5):417-21

Department of Surgery, Charing Cross Hospital, Fulham Palace Road, London, UK.

Background: International smuggling of cocaine by internal concealment is a serious and growing problem. People who engage in this practice are commonly referred to as body packers or mules. The most serious risks associated with body packing include intestinal obstruction and death from cocaine intoxication. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769129PMC
October 2009
6 Reads

Effect of whole gut irrigation solutions on gastrointestinal smooth muscle activity.

J Pediatr Surg 2009 Sep;44(9):1719-24

Department of Pediatric Surgery, Medical Faculty, Kirikkale University, 71100 Kirikkale, Turkey.

Background/purpose: It has been suggested that whole gut irrigation (WGI), which is a preparation method for large bowel surgery or colonoscopy, increases gastrointestinal motility by creating a gastrocolic reflex. An experimental study was performed to evaluate the effect of different WGI solutions on gastrointestinal smooth muscle activity.

Materials And Methods: Thirty Wistar albino rats weighing 200 to 250 g were enrolled in the study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223468090013
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http://dx.doi.org/10.1016/j.jpedsurg.2009.02.007DOI Listing
September 2009
5 Reads

The effect of decontamination procedures on the pharmacokinetics of venlafaxine in overdose.

Clin Pharmacol Ther 2009 Oct 15;86(4):403-10. Epub 2009 Jul 15.

School of Pharmacy, University of Otago, Dunedin, New Zealand.

The aim of this work was to investigate the pharmacokinetics (PK) of venlafaxine in overdose and the effects of single-dose activated charcoal (SDAC) and whole-bowel irrigation (WBI), alone or in combination, as methods of decontamination. The data included 339 concentration-time points from 76 venlafaxine overdose events (median dose 2,625 (150-13,500 mg)); 69 were slow-release doses. SDAC, WBI, a combination of both, or no decontamination were administered to patients as decided by the treating clinician. Read More

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http://dx.doi.org/10.1038/clpt.2009.114DOI Listing
October 2009
3 Reads

[Decontamination and antidotes in acute cases of poisoning].

Ther Umsch 2009 May;66(5):331-4

Schweizerisches Toxikologisches Informationszentrum, Zürich.

In acute poisoning the maintenance or reconstitution of vital functions is the first and most critical action. All subsequent therapies and the prognosis depend on the identification of the causative agent and on information about substance-specific toxicity. Despite incomplete evidence the concept of harm reduction by decreased absorption of the toxicants and by shortening the course of illness is consistent with toxicokinetic-dynamic principles and is therefore still used by clinical toxicologists. Read More

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https://econtent.hogrefe.com/doi/10.1024/0040-5930.66.5.331
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http://dx.doi.org/10.1024/0040-5930.66.5.331DOI Listing
May 2009
17 Reads

Severe iron intoxication treated with exchange transfusion.

BMJ Case Rep 2009 8;2009. Epub 2009 May 8.

Pediatric Intensive Care Unit, Odense University Hospital, Odense, Denmark.

An 18-month-old previous healthy girl who had ingested 442 mg elemental iron/kg was admitted to a paediatric intensive care unit. The child was treated with gastric lavage, whole bowel irrigation and intravenous deferoxamine. After 2 h of standard therapy serum iron had risen threefold to 1362 µg/dl (244 µmol/l). Read More

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http://dx.doi.org/10.1136/bcr.01.2009.1445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3029243PMC
November 2011
3 Reads

Successful whole bowel irrigation in self-poisoning with potassium capsules.

Clin Toxicol (Phila) 2008 Dec;46(10):1102-3

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http://dx.doi.org/10.1080/15563650802415165DOI Listing
December 2008
2 Reads

Lithium overdose with electrocardiogram changes suggesting ischemia.

J Med Toxicol 2008 Sep;4(3):170-2

Department of Emergency Medicine, Brody School of Medicine at East Carolina University, Greenville, North Carolina, USA.

Background: Lithium toxicity is associated with electrocardiogram (ECG) changes, but changes suggestive of an ST segment elevation myocardial infarction have not been reported.

Case Report: A 46-year-old incarcerated man suffering from diabetes, hypertension, and schizoaffective/bipolar disorder was treated with lithium 1,200 mg twice daily. Two days prior to presentation the patient became confused, ataxic, and anorexic in jail. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3550041PMC
September 2008
4 Reads

Whole bowel irrigation and the hemodynamically unstable calcium channel blocker overdose: primum non nocere.

J Emerg Med 2010 Feb 9;38(2):171-4. Epub 2008 Jul 9.

The Toxikon Consortium at Cook County Hospital, Chicago, Illinois 60612, USA.

Sustained-release calcium channel blocker (CCB SR) overdoses are potentially life-threatening ingestions. These patients may not become hemodynamically unstable until many hours after ingestion. On theoretical grounds, some have suggested that whole bowel irrigation (WBI) with polyethylene glycol electrolyte lavage solution may be of value in the management of these cases. Read More

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http://dx.doi.org/10.1016/j.jemermed.2007.11.100DOI Listing
February 2010
4 Reads

Severe iron intoxication treated with exchange transfusion.

Arch Dis Child 2008 Apr;93(4):321-2

Pediatric Intensive Care Unit, Afdeling V, Odense University Hospital, Sdr. Boulevard 29, 5000 Odense C., Denmark.

An 18-month-old previous healthy girl who had ingested 442 mg elemental iron/kg was admitted to a paediatric intensive care unit. The child was treated with gastric lavage, whole bowel irrigation and intravenous deferoxamine. After 2 h of standard therapy serum iron had risen threefold to 1362 microg/dl (244 micromol/l). Read More

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http://dx.doi.org/10.1136/adc.2007.123240DOI Listing
April 2008
2 Reads

Gastrointestinal decontamination of the poisoned patient.

Pediatr Emerg Care 2008 Mar;24(3):176-86; quiz 187-9

Department of Emergency Medicine, Wright State University Boonshoft School of Medicine, Dayton, OH 45429, USA.

Gastrointestinal decontamination has been a historically accepted modality in the emergency management of oral intoxicants. Theoretically, gastric and whole-bowel emptying procedures hinder absorption, remove toxic substances, prevent clinical deterioration, and hasten recovery. This article presents a current overview of gastrointestinal decontamination. Read More

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http://dx.doi.org/10.1097/PEC.0b013e318166a092DOI Listing
March 2008
4 Reads