5,105 results match your criteria Whipple Disease


Outcomes associated with robotic approach to pancreatic resections.

J Gastrointest Oncol 2018 Oct;9(5):936-941

Department of Gastrointestinal Oncology, Sarasota Memorial Hospital, Sarasota, FL, USA.

Minimally invasive techniques have improved post-operative outcomes, however, the majority of pancreatic surgery, known for its complexity, is still performed via open approaches. The development of robotics has improved dexterity which may allow for application in more complex surgeries. We queried a prospectively maintained robotic database to identify patients who underwent robotic pancreatic resection by a single surgeon between 2012 and 2016. Read More

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October 2018
5 Reads

Minimal-invasive approach to pancreatoduodenectomy is associated with lower early postoperative morbidity.

Am J Surg 2018 Apr 19. Epub 2018 Apr 19.

Department of Surgery, University of California, San Francisco, USA; Department of Surgery, San Francisco VA Medical Center, USA. Electronic address:

Objectives: We aim to investigate the impact of the operation time for pancreatoduodenectomy (PD) in different surgical approaches.

Methods: The NSQIP database was used to examine the clinical data of patients underwent PD during 2014-2016.

Results: We sampled a total of 6151 patients who underwent elective PD. Read More

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April 2018
6 Reads

Pancreaticoduodenectomy with right gastric vessels preservation: impact on intraoperative and postoperative outcomes.

ANZ J Surg 2018 Nov 29. Epub 2018 Nov 29.

Department of Surgery, Léon Bérard Cancer Center, Lyon, France.

Background: Sympathetic denervation of the antropyloric area combined with relative devascularization from division of the right gastric vessels (RGV) during pancreaticoduodenectomy (PD) could predispose to delayed gastric emptying (DGE). Therefore, some authors advocated for RGV preservation (RGVP), where feasibility and utility for the prevention of post-operative DGE have never been investigated.

Methods: From 2011 to 2014, patients who underwent classic Whipple PD (CWPD, n = 34), standard pylorus-preserving PD (PPPD, n = 44) or PPPD with RGVP (n = 22) were retrospectively analysed. Read More

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November 2018

Immunotherapy, Radiotherapy, and Hyperthermia: A Combined Therapeutic Approach in Pancreatic Cancer Treatment.

Cancers (Basel) 2018 Nov 28;10(12). Epub 2018 Nov 28.

Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Pancreatic cancer (PC) has the highest mortality rate amongst all other cancers in both men and women, with a one-year relative survival rate of 20%, and a five-year relative survival rate of 8% for all stages of PC combined. The Whipple procedure, or pancreaticoduodenectomy, can increase survival for patients with resectable PC, however, less than 20% of patients are candidates for surgery at time of presentation. Most of the patients are diagnosed with advanced PC, often with regional and distant metastasis. Read More

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November 2018

The Three H's: Head, Heart, and Heat Considerations in Soccer.

Am J Orthop (Belle Mead NJ) 2018 Oct;47(10)

211 E Ontario St, Suite 200, Chicago, IL 60611, USA. Email:

Soccer requires significant physical conditioning and endurance, as well as the physicality required for contact play. In order to keep athletes safe, it is important that coaches, medical staff, and the players themselves are educated on the most common dangers to their health that they may encounter on a soccer pitch. This article aims to review the current literature and recommendations on concussion, cardiovascular considerations, and heat-related illness as they relate to competitive soccer, with a goal of educating all those who help to keep athletes healthy and competing to their full potential. Read More

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October 2018
1 Read

Preoperative administration of the 5-HT4 receptor agonist prucalopride reduces intestinal inflammation and shortens postoperative ileus via cholinergic enteric neurons.

Gut 2018 Nov 24. Epub 2018 Nov 24.

Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium.

Objectives: Vagus nerve stimulation (VNS), most likely via enteric neurons, prevents postoperative ileus (POI) by reducing activation of alpha7 nicotinic receptor (α7nAChR) positive macrophages (mMφ) and dampening surgery-induced intestinal inflammation. Here, we evaluated if 5-HT4 receptor (5-HT4R) agonist prucalopride can mimic this effect in mice and human.

Design: Using Ca imaging, the effect of electrical field stimulation (EFS) and prucalopride was evaluated in situ on mMφ activation evoked by ATP in jejunal tissue. Read More

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November 2018
4 Reads

Ventricular global longitudinal strain is altered in children with sickle cell disease.

Br J Haematol 2018 Dec 19;183(5):796-806. Epub 2018 Nov 19.

Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA.

Cardiac disease is the primary cause of death in sickle cell disease (SCD). Right and left ventricular global longitudinal strain (RVGLS, LVGLS) are early markers of systolic dysfunction but are not well investigated among children with SCD. One hundred and forty-three patients with HbSS or HbSβ -thalassaemia (median age 11 years, range 5-19 years) and 71 controls matched for age and sex were compared. Read More

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December 2018
4 Reads

Robotic pancreatoduodenectomy for a solid pseudopapillary tumor in a ten-year-old child.

Surg Oncol 2018 Dec 25;27(4):635-636. Epub 2018 Jul 25.

Dept. of Surgery, UMC Utrecht Cancer Center, Utrecht, The Netherlands.

Background: Pancreatoduodenectomy (Whipple resection) in children is feasible though rarely indicated. In several pediatric malignancies of the pancreas, however, it may be the only curative strategy [1]. With the emergence of robotic pancreatoduodenectomy as at least a clinically equivalent alternative to open surgery [2], it remains to be determined whether the pediatric population may potentially benefit from this minimally invasive procedure. Read More

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December 2018
1 Read

Androgen receptor (AR)/miR-520f-3p/SOX9 signaling is involved in the altering hepatocellular carcinoma (HCC) cell sensitivity to the Sorafenib therapy under hypoxia via increasing cancer stem cells phenotype.

Cancer Lett 2018 Nov 15. Epub 2018 Nov 15.

George Whipple Lab for Cancer Research, Departments of Pathology, Urology, Radiation Oncology and the Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA; Sex Hormone Research Center, China Medical University/Hospital, Taichung 404, Taiwan. Electronic address:

Early studies indicated that the androgen receptor (AR) might play key roles to impact hepatocellular carcinoma (HCC) progression at different stages. Its linkage to hypoxia, a condition that occurrs frequently during the HCC progression, however, remains unclear. Here we found that AR/miR-520f-3p/SOX9 signaling is involved in the altering HCC cells sensitivity to the Sorafenib therapy under hypoxia via increasing the cancer stem cells (CSCs) population. Read More

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November 2018
4 Reads

Anastomotic reconstruction and external drainage of Wirsung's duct as treatment for pancreaticojejunal stenosis following pancreaticoduodenectomy.

Cir Esp 2018 Nov 15. Epub 2018 Nov 15.

Unidad de Cirugía HPB y Trasplante de Órganos Abdominales, Hospital Universitario 12 de Octubre, Madrid, España; Departamento de Cirugía de la Facultad de Medicina, Universidad Complutense de Madrid, Madrid, España.

Stenosis of the pancreaticodigestive anastomosis (pancreaticogastrostomy and pancreaticojejunostomy) is a very rare complication that usually develops several years after pancreaticoduodenectomy (PD). Only a few cases have been previously reported. We have reviewed the literature and present 2 more cases of pancreaticojejunostomy stenosis that started with episodes of recurrent acute pancreatitis 6 years and 1 year after PD, respectively. Read More

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November 2018
10 Reads

Percutaneous extrahepatic splenomeso-caval shunt creation in a patient with portal vein thrombosis after Whipple procedure.

Clin Imaging 2019 Jan - Feb;53:221-224. Epub 2018 Oct 23.

Division of Vascular and Interventional Radiology, Department of Radiology, Mayo Clinic, Rochester, MN, USA.

A 72-year-old male presented with refractory ascites secondary to portal vein occlusion with cavernomatous transformation following pancreaticoduodenectomy (Whipple procedure). Due to the unfavorable anatomy, transjugular intrahepatic portosystemic shunt was not an option. However, given patency of the spleno-mesenteric confluence and absence of the pancreatic head after the Whipple procedure, a splenomeso-caval shunt was successfully created using a transjugular-transsplenic rendezvous technique. Read More

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October 2018
1 Read

Whipple's Pancreaticoduodenectomy in Pediatric Patients: An Experience from a Tertiary Care Center.

J Indian Assoc Pediatr Surg 2018 Oct-Dec;23(4):212-215

Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, India.

Purpose: Whipple's pancreaticoduodenectomy (WPD) is rarely required in children. However, WPD is the only option with pathologies involving the head of the pancreas requiring surgical excision. The objective of our study was to review our experience with WPD performed on children. Read More

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November 2018
1 Read

[Analysis of the digital preference for age in the pharmacovigilance system in Brazil, 2008-2013].

Cien Saude Colet 2018 Nov;23(11):3935-3946

Programa de Pós-Graduação em Epidemiologia, Faculdade de Medicina da Universidade Federal do Rio Grande do Sul. R. Ramiro Barcelos 2.400/2º, Bom Fim. 90035-003 Porto Alegre RS Brasil.

The scope of this article is to analyze the digital preference for the "age" variable in the database of cases of adverse drug events reported between 2008 and 2013 in the pharmacovigilance system in Brazil. The database was analyzed in three stages: 1) Initial exploration; 2) standardization of variables; and 3) duplicate records management. The digital preference for the "age" variable according to sex and grouped regions of the country, was determined using the Whipple and Myers methods and also measured by the adhesion test based on statistical χ2 at 5% significance level. Read More

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November 2018
1 Read

Targeting AR-Beclin 1 Complex-Modulated Growth Factor Signaling Increases the Antiandrogen-Enzalutamide Sensitivity to Better Suppress the Castration-Resistant Prostate Cancer Growth.

Cancer Lett 2018 Nov 10. Epub 2018 Nov 10.

George Whipple Lab for Cancer Research, Departments of Pathology, Urology, Radiation Oncology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, 14642, USA; Sex Hormone Research Center, China Medical University, Taichung, 404, Taiwan. Electronic address:

While the recently developed antiandrogen Enzalutamide (Enz) can extend survival for 4.8 months in castration-resistant prostate cancer (CRPC) patients, eventually most of these CRPC patients may develop resistance to the Enz without a clear mechanism. Here we found the expression of Beclin 1 was decreased in both Enz-resistant (EnzR) cell lines (EnzR1-C4-2 and EnzR2-C4-2B) as compared to their parental Enz-sensitive (EnzS) (EnzS1-C4-2 and EnzS2-C4-2B) cells, and targeting the Beclin 1 could lead to increase the Enz-sensitivity in these two CRPC cell lines. Read More

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November 2018
1 Read

A Bibliometric Study of Authorship and Collaboration Trends Over the Past 30 Years in Four Major Musculoskeletal Science Journals.

Calcif Tissue Int 2018 Nov 11. Epub 2018 Nov 11.

Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.

This study explored changes in bibliometric variables over the last 30 years for four major musculoskeletal science journals (BONE®), Calcified Tissue International® (CTI®), Journal of Bone and Mineral Research® (JBMR®), and Journal of Orthopaedic Research® (JOR®), with a specific focus on author gender. Bibliometric data were collected for all manuscripts in 1985 (BONE®, CTI®, JOR®), 1986 (JBMR®), 1995, 2005, and 2015; 2776 manuscripts met inclusion criteria. Manuscripts from Europe were more often published in BONE® or CTI®, while those from North America in JBMR® or JOR®. Read More

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November 2018

Gemcitabine-induced skin necrosis.

SAGE Open Med Case Rep 2018 30;6:2050313X18809268. Epub 2018 Oct 30.

Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA.

Since its emergence as a chemotherapy agent, gemcitabine has been associated with cutaneous adverse reactions. Rash is reported to be the most common cutaneous adverse effect. Other reported cutaneous reactions in the literature include bullous dermatosis, pseudocellulitis, subacute cutaneous lupus alopecia, and palmar-plantar erythrodysesthesia. Read More

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October 2018
2 Reads

Diffuse Large B-Cell Lymphoma With Striking Intrasinusoidal Pseudoglandular Growth Pattern as a Diagnostic Dilemma Mimicking Metastatic Poorly Differentiated Pancreatic Adenocarcinoma in an Intraabdominal Lymph Node.

Int J Surg Pathol 2018 Nov 4:1066896918810866. Epub 2018 Nov 4.

1 University of Southern California, Los Angeles, CA, USA.

We report an unusual intrasinusoidal growth pattern of an intraabdominal diffuse large B-cell lymphoma both clinically and histologically mimicking a metastatic adenocarcinoma. A 66-year-old woman presented with a high-grade distal biliary stricture with multiple enlarged abdominal lymph nodes. Frozen section at the time of pancreatoduodenectomy ("Whipple") demonstrated cohesive nests of large atypical cells within a totally effaced lymph node presenting a diagnostic challenge. Read More

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November 2018
1 Read

Whipple procedure.

Authors:

AORN J 2018 Nov;108(5):P11-P13

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November 2018

Histochemistry in the diagnosis of non-neoplastic gastrointestinal disorders.

Semin Diagn Pathol 2018 Nov 16;35(6):370-380. Epub 2018 Oct 16.

Department of Pathology, St. Jude Medical Center, Fullerton, CA 92835, United States. Electronic address:

The alimentary tract serves as host to a large number of diseases. In the non-neoplastic group of disorders, conventional histochemistry continues to play an important diagnostic role. It is particularly important in recognizing specific infectious diseases, such as Helicobacter gastritis, Whipple disease, intestinal tuberculosis and other forms of mycobacteriosis, malakoplakia, intestinal spirochetosis, fungal enteritides, amebiasis, cryptosporidiosis, isosporiasis, and microsporidiosis. Read More

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November 2018
6 Reads

From Whipple Disease to Tropheryma whipplei Infection.

Authors:
Didier Raoult

Clin Infect Dis 2018 Oct 22. Epub 2018 Oct 22.

Aix Marseille Université, Institut de recherche pour le développement, Microbes Evolution Phylogenie Et Infections.

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October 2018
1 Read

Detection of Tropheryma whipplei in stool samples by one commercial and two in-house real-time PCR assays.

Trop Med Int Health 2018 Oct 22. Epub 2018 Oct 22.

Institute for Medical Microbiology, Virology and Hygiene, University Medicine Rostock, Rostock, Germany.

Objective: Tropheryma whipplei, the causative agent of Whipple's disease, can also be identified in stool samples of humans without systemic disease. It is much more frequently detected in human stool samples in tropical environments than in industrialized countries. PCR-screening has been applied for point prevalence studies and environmental assessments in tropical settings, but results depend on the applied assay. Read More

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October 2018
2 Reads

[F]FDG-PET for evaluating pediatric Rosai-Dorfman disease.

Pediatr Hematol Oncol 2018 Oct 22:1-4. Epub 2018 Oct 22.

e Division of Pediatric Hematology/Oncology, Department of Pediatrics , University of Mississippi Medical Center , Jackson , Mississippi , USA.

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October 2018
1 Read

Systematic review of movement disorders and oculomotor abnormalities in Whipple's disease.

Mov Disord 2018 Nov 19;33(11):1700-1711. Epub 2018 Oct 19.

Movement Disorders Research Center, Toront Western Hospital, Toronto, Ontario, Canada.

Whipple's disease, affecting the CNS, can cause a wide variety of symptoms. Movement disorders are very prevalent, and some are pathognomonic of the disease. This systematic review analyzed all published cases of movement disorders because of CNS Whipple's disease, providing detailed information on clinical and associated features. Read More

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November 2018
1 Read

Collecting and delivering progress feedback: A meta-analysis of routine outcome monitoring.

Psychotherapy (Chic) 2018 12;55(4):520-537

Department of Psychological Medicine, Faculty of Medical and Health Sciences, Auckland University.

This systematic review and meta-analysis examines the impact of measuring, monitoring, and feeding back information on client progress to clinicians while they deliver psychotherapy. It considers the effects of the 2 most frequently studied routine outcome monitoring (ROM) practices: The Partners for Change Outcome Management System and the Outcome Questionnaire System. Like other ROM practices, they typify attempts to enhance routine care by assisting psychotherapists in recognizing problematic treatment response and increasing collaboration between therapist and client to overcome poor treatment response. Read More

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December 2018

Osteomyelitis as a Result of Pancreaticojejunostomy Stent Migration after Whipple Procedure.

ACG Case Rep J 2018 26;5:e67. Epub 2018 Sep 26.

Division of Gastroenterology, Advocate Lutheran General Hospital, Park Ridge, IL.

Pancreaticoduodenectomy, or Whipple procedure, is a high-risk surgical procedure commonly performed for tumors of the pancreatic head. The pancreatico-enteric anastomosis is an important component of this procedure. The maturation and adequate healing of this anastomotic site is critical to decrease the risk of postoperative pancreatic fistulas. Read More

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September 2018
1 Read

Mortality after pancreaticoduodenectomy: assessing early and late causes of patient death.

J Surg Res 2018 Nov 27;231:304-308. Epub 2018 Jun 27.

Department of Surgery, University of Virginia, Charlottesville, Virginia; Surgery Outcomes Research Center, University of Virginia, Charlottesville, Virginia; Division of Surgical Oncology, University of Virginia, Charlottesville, Virginia. Electronic address:

Background: Safety of pancreaticoduodenectomy has improved significantly in the past 3 decades. Current inpatient and 30-d mortality rates are low. However, incidence and causes of 90-d and 1-y mortality are poorly defined and largely unexplored. Read More

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November 2018
1 Read

Estrogen receptor β promotes the vasculogenic mimicry (VM) and cell invasion via altering the lncRNA-MALAT1/miR-145-5p/NEDD9 signals in lung cancer.

Oncogene 2018 Sep 24. Epub 2018 Sep 24.

George Whipple Lab for Cancer Research, Departments of Urology and Pathology, University of Rochester Medical Center, Rochester, NY, 14642, USA.

While estrogen receptor β (ERβ) may impact the progression of non-small cell lung cancer (NSCLC), its linkage to alteration of the vasculogenic mimicry (VM) formation to influence the NSCLC cell invasion remains unclear. Here, we analyzed immunohistochemistry data from NSCLC tissues and found that ERβ-positive NSCLC female patients had worse survival outcomes than those of ERβ-negative NSCLC female patients. In vitro studies using multiple NSCLC cell lines also revealed that ERβ could increase the VM formation and cell invasion. Read More

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September 2018

Targeting the androgen receptor (AR) with AR degradation enhancer ASC-J9 led to increase docetaxel sensitivity via suppressing the p21 expression.

Cancer Lett 2018 Sep 21. Epub 2018 Sep 21.

George Whipple Lab for Cancer Research, Departments of Pathology, Urology, Radiation Oncology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, 14642, USA; Sex Hormone Research Center, China Medical University and Hospital, Taichung, 404, Taiwan. Electronic address:

Chemotherapy with docetaxel remains as the effective therapy to suppress castration resistant prostate cancer (CRPC) in some patients. However, most chemotherapy with docetaxel eventually fails with the development of docetaxel resistance after 18-weeks of treatment. Here we found docetaxel treatment might have adverse effect of increasing the androgen receptor (AR) protein level in the CRPC cells, and combined docetaxel with anti-AR therapy using AR-shRNA or the AR degradation enhancer ASC-J9 may increase docetaxel sensitivity to better suppress the CRPC cell growth. Read More

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September 2018

ADT with antiandrogens in prostate cancer induces adverse effect of increasing resistance, neuroendocrine differentiation and tumor metastasis.

Cancer Lett 2018 Dec 15;439:47-55. Epub 2018 Sep 15.

George Whipple Lab for Cancer Research, Department of Pathology, Department of Urology, Department of Radiation Oncology, The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, 14642, USA; Sex Hormone Research Center, China Medical University/Hospital, Taichung, 404, Taiwan. Electronic address:

Prostate cancer (PCa) is the most common cancer and the 2nd leading cause of cancer-related deaths among men in the United States. Androgen-deprivation-therapy (ADT) with antiandrogens to target the androgens/androgen receptor (AR) signals remains the standard therapy for advanced PCa. However, most of the PCa patients who received ADT with antiandrogens, including the recently developed Enzalutamide (Enz) that might extend PCa patients survival an extra 4. Read More

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December 2018
3 Reads

The role of preoperative therapy prior to pancreatoduodenectomy for distal cholangiocarcinoma.

Am J Surg 2018 Sep 6. Epub 2018 Sep 6.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, USA.

Background: Although increasingly administered to patients with pancreatic ductal adenocarcinoma, the role of preoperative therapy for patients with distal cholangiocarcinoma is undefined.

Methods: All patients with distal cholangiocarcinoma who underwent pancreatoduodenectomy between 1999 and 2014 were retrospectively reviewed. Differences in clinicopathologic characteristics and overall survival (OS) were compared between patients who underwent surgery de novo and those who received preoperative therapy. Read More

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September 2018

Trends in Robotic Pancreaticoduodenectomy and Distal Pancreatectomy.

J Laparoendosc Adv Surg Tech A 2018 Sep 14. Epub 2018 Sep 14.

American British Cowdray Hospital , México City, México.

Background: Pancreatic surgery remains a challenge even to the most experienced surgeons. Despite significant advances in the field, morbidity and mortality continue to have elevated rates even in specialized, high-volume centers. The rise of laparoscopy in the past decades has improved outcomes for patients, but remains unused due to the technical complexities involved. Read More

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September 2018
8 Reads

Pancreatoduodenectomy for pancreatic head tumors in the elderly - Systematic review and meta-analysis.

Surg Oncol 2018 Sep 17;27(3):346-364. Epub 2018 May 17.

2ndDepartment of General Surgery, Jagiellonian University Medical College, Kopernika 21, 31-501, Krakow, Poland; Centre for Research, Training and Innovation in Surgery (CERTAIN Surgery), Krakow, Poland.

The age at which patients are undergoing pancreatoduodenectomy is increasing worldwide. The data on the outcome of this surgical procedure in the elderly is constantly expanding. This meta-analysis aims to assess the safety of pancreatoduodenectomy in elderly population, primarily focusing on morbidity and mortality. Read More

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September 2018
6 Reads

Maternal reproductive senescence shapes the fitness consequences of the parental age difference in ruffed lemurs.

Proc Biol Sci 2018 Sep 12;285(1886). Epub 2018 Sep 12.

Université de Lyon, F-69000, Lyon; Université Lyon 1; CNRS, UMR5558, Laboratoire de Biométrie et Biologie Evolutive, F-69622 Villeurbanne, France.

In humans, pronounced age differences between parents have deleterious fitness consequences. In particular, the number of children is lower when mothers are much older than fathers. However, previous analyses failed to disentangle the influence of differential parental age from a direct age effect of each parent. Read More

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September 2018
1 Read

Bulked-Segregant Analysis Coupled to Whole Genome Sequencing (BSA-Seq) for Rapid Gene Cloning in Maize.

G3 (Bethesda) 2018 11 6;8(11):3583-3592. Epub 2018 Nov 6.

Plant Biology Graduate Program and Biology Department, University of Massachusetts Amherst, Amherst, MA 01003

Forward genetics remains a powerful method for revealing the genes underpinning organismal form and function, and for revealing how these genes are tied together in gene networks. In maize, forward genetics has been tremendously successful, but the size and complexity of the maize genome made identifying mutant genes an often arduous process with traditional methods. The next generation sequencing revolution has allowed for the gene cloning process to be significantly accelerated in many organisms, even when genomes are large and complex. Read More

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November 2018
10 Reads

A case of a right accessory hepatic duct diagnosed during a Whipple procedure.

Int J Surg Case Rep 2018 23;51:210-212. Epub 2018 Aug 23.

Department of Anatomy and Surgical Anatony, Medical School, National and Kapodestrian University of Athens, Athens, Greece.

Introduction: Although anatomic variations of the bile tract are relatively common and can be present in about 28% of patients, existence of an accessory right hepatic duct that confluence on the common bile duct is quite rare.

Presentation Of Case: We present a rare case of a caucasian 78-years-old patient, with accessory right hepatic duct which was diagnosed intraoperatively. The patient was submitted to Whipple procedure due to a mass in the head of pancreas. Read More

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August 2018
2 Reads

Ocular Whipple Disease: Report of Three Cases.

Ocul Immunol Inflamm 2018 Sep 7:1-4. Epub 2018 Sep 7.

c Advanced Eye Centre , Post Graduate Institute of Medical Education and Research , Chandigarh , India.

Purpose: To emphasize the different manifestations of ocular involvement in Whipple disease with challenge in establishing the diagnosis as clinical, laboratory, and histological features could mimic other uveitis entities.

Methods: Case reports of three patients.

Results: The first patient was an African male suffering from a chronic bilateral keratoconjunctitivitis that was initially misdiagnosed as a chronic allergic conjunctivitis. Read More

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September 2018
1 Read

Successful Localization of the Source of Hemorrhage in Patient with Post-Whipple Surgery by Tc-Labelled Red Blood Cell Scintigraphy.

Case Rep Radiol 2018 14;2018:1381203. Epub 2018 Aug 14.

Department of Radiology, Division Nuclear Medicine Division & Cardiothoracic Radiology Division, King Faisal Specialist Hospital & Research Centre, P.O. Box 3354, MBC 28, Riyadh 11211, Saudi Arabia.

Gastrointestinal Bleeding Scintigraphy (GIBS) of Tc-labelled red blood cells is a relatively simple examination to perform, with high diagnostic accuracy and a relatively lower radiation dose. A positive scan can either suggest surgery without further investigation or can indicate angiography, a more targeted procedure. Whipple pancreatoduodenectomy is most often performed for tumors of the head of the pancreas. Read More

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August 2018
7 Reads

Bronchobiliary fistula: a rare complication after pancreaticoduodenectomy.

BMJ Case Rep 2018 Sep 4;2018. Epub 2018 Sep 4.

University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.

Biliary anatomic pathologies are rare disease occurrences that can result from a number of causes, most commonly iatrogenic, infectious and malignant aetiologies. Communications between the biliary and bronchial systems are even rarer and few cases have been documented in the literature. The present study describes a case of a 70-year-old man who underwent a pancreaticoduodenectomy (Whipple Procedure) as a curative procedure for an early stage neuroendocrine tumour. Read More

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September 2018
12 Reads

Targeting newly identified ERβ/TGF-β1/SMAD3 signals with the FDA-approved anti-estrogen Faslodex or an ERβ selective antagonist in renal cell carcinoma.

Mol Oncol 2018 Dec 30;12(12):2055-2071. Epub 2018 Oct 30.

George Whipple Lab for Cancer Research, Departments of Urology and Pathology, University of Rochester Medical Center, NY, USA.

Renal cell carcinoma (RCC) has the third highest mortality rate among urological tumors, and 20-30% of RCC patients present with metastatic RCC at the time of diagnosis. Although recent studies have indicated that estrogen receptor β (ERβ) could play promoting roles in RCC progression, the detailed mechanisms remain to be clarified. In the present study, we found that expression of ERβ, but not ERα, increases with tumor stage and grade, and also observed that modification of ERβ signals using estrogens/anti-estrogens, shRNA knockdown of ERβ and overexpression of ERβ using ectopic cDNA affects RCC cell proliferation, migration and invasion. Read More

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December 2018
5.330 Impact Factor

Practical experience implementing supervised exercise therapy for peripheral artery disease in urban and rural Minnesota.

J Vasc Nurs 2018 09 29;36(3):157-159. Epub 2018 Jul 29.

School of Nursing, University of Minnesota, Minneapolis, Minnesota. Electronic address:

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September 2018
1 Read

Management of Biliary Stricture Following Emergent Pancreaticoduodenectomy for Trauma: Report of Two Cases.

Cureus 2018 Jun 18;10(6):e2829. Epub 2018 Jun 18.

Trauma Surgery, Creighton University School of Medicine, Phoenix, USA.

Stricturing of the biliary-enteric anastomosis is a known complication of emergent pancreaticoduodenectomy (PD) performed for trauma. Percutaneous techniques have become the first-line option for the management of these strictures. In cases where percutaneous intervention fails, surgical revision of the biliary enteric anastomosis is necessary. Read More

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June 2018
10 Reads

[Ampulloma treatment with Whipple surgery. First case report in the regional hospital of Tumbes].

Rev Gastroenterol Peru 2018 Apr-Jun;38(2):187-191

Hospital Regional de Tumbes. Tumbes, Perú.

To report the first case of Whipple surgery performed at the Regional Hospital of Tumbes for the treatment of ampullary adenocarcinoma with successful results. A case report of a patient with diagnosis of ampullary adenocarcinoma, in whom was performed the first Whipple surgery at the Regional Hospital of Tumbes, in October, 2014. The patient diagnosed with an obstructive jaundice syndrome due to ampullary adenocarcinoma underwent Whipple surgery. Read More

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August 2018
1 Read

Three-dimensional characterization of debris clouds under hypervelocity impact with pulsed digital inline holography.

Appl Opt 2018 Jul;57(21):6145-6152

The increasing space debris poses a great threat to in-orbit spacecraft and satellites, because its hypervelocity impact can bring about fatal mechanical and electrical damage to them. This work applies pulsed digital inline holography (DIH) to measure three-dimensional (3D) positions and shapes of the debris clouds generated by the hypervelocity impact in the Whipple shield. Detailed operation procedures of synchronizing the pulse DIH system with the impact event and removing the strong plasma radiation are presented, ensuring the successful capture of the transient state of ultrafast ejecta. Read More

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Impact of neoadjuvant therapy on postoperative outcomes after pancreaticoduodenectomy.

J Surg Oncol 2018 Sep 16;118(3):455-462. Epub 2018 Aug 16.

Department of Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina.

Background: Surgical resection provides the only potentially curative treatment of pancreatic cancer. Neoadjuvant chemotherapy and/or radiation (NAT) is used to downstage patients with borderline resectable tumors. The objective of this study was to examine the postoperative morbidity and mortality of NAT after pancreaticoduodenectomy (PD) for pancreatic ductal adenocarcinoma (PDA). Read More

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September 2018
5 Reads

Reconstruction options following pancreaticoduodenectomy after Roux-en-Y gastric bypass: a systematic review.

World J Surg Oncol 2018 Aug 13;16(1):168. Epub 2018 Aug 13.

Division of Surgical Oncology, Department of Surgery, Drexel University College of Medicine, 245 N. 15th Street, Suite 7150, Philadelphia, PA, 19102, USA.

Background: Obesity is a risk factor for pancreatic cancer which may be treated with Roux-en-Y gastric bypass and represents an increasing morbidity. Post-RYGB anatomy poses considerable challenges for reconstruction after pancreaticoduodenectomy (PD), a growing problem encountered by surgeons. We characterize specific strategies used for post-PD reconstruction in the RYGB patient. Read More

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August 2018
9 Reads

Adenomyomatous hyperplasia of distal common bile duct: a case report and review of the literature.

J Surg Case Rep 2018 Aug 7;2018(8):rjy204. Epub 2018 Aug 7.

Department of Surgery, Maimonides Medical Center, Brooklyn, NY, USA.

Adenomyomatous hyperplasia (AH) is commonly found in the gallbladder and is considered a tumor-like inflammatory lesion arising from Rokitansky-Aschoff sinus. It is extremely rare in the extrahepatic bile duct and only 15 cases have been reported to date. We describe a 63-year-old male patient who presented with cholangitis, underwent an extensive diagnostic workup, and ultimately had a Whipple procedure. Read More

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Fish-Mouth Closure of the Pancreatic Stump and Parachuting of the Pancreatic End with Double U Trans-Pancreatic Sutures for Pancreatico-Jejunostomy.

Authors:
Woo Jung Lee

Yonsei Med J 2018 Sep;59(7):872-878

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.

Purpose: Leakage of pancreatico-jejunal anastomosis (PJ) remains the primary cause of morbidity and mortality after Whipple's operation. To reduce the occurrence thereof, the present author recently began to apply a modification of the Blumgart method of anastomosis after Whipple's operation (hereinafter referred to as Lee's method), with very good results.

Materials And Methods: The modified method and technique utilizes fish-mouth closure of a beveled pancreatic stump and parachuting of the pancreatic end with double U trans-pancreatic sutures (symmetric horizontal mattress-type sutures between the full thickness of the pancreas and the jejunal limb) after duct-to-mucosa pancreatico-jejunostomy. Read More

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September 2018
14 Reads

Tropheryma whipplei Increases Expression of Human Leukocyte Antigen-G on Monocytes to Reduce Tumor Necrosis Factor and Promote Bacterial Replication.

Gastroenterology 2018 11 1;155(5):1553-1563. Epub 2018 Aug 1.

Aix Marseille Univ, IRD, APHM, MEPHI, IHU-Mediterranee Infection, Marseille, France. Electronic address:

Background & Aims: Infection with Tropheryma whipplei has a range of effects-some patients can be chronic carriers without developing any symptoms, whereas others can develop systemic Whipple disease, characterized by a lack a protective inflammatory immune response. Alterations in HLA-G function have been associated with several diseases. We investigated the role of HLA-G during T whipplei infection. Read More

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November 2018
4 Reads

Fifty years after its discharge, methylation of legacy mercury trapped in the Penobscot Estuary sustains high mercury in biota.

Sci Total Environ 2018 Nov 21;642:1340-1352. Epub 2018 Jun 21.

Ramboll Environ Inc., USA. Electronic address:

Fifty years ago, the Penobscot Estuary was contaminated by mercury discharged from the chlor-alkali plant located in Orrington, Maine, USA. Almost all of the mercury was discharged from the plant during the late 1960s and early 1970s. Despite the much lower mercury discharges in recent decades, present-day concentrations in surface sediment remain high (averaging 350-1100 ng/g dw) and are still high in blood of marsh birds (up to 10. Read More

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November 2018
5 Reads