2,759 results match your criteria Whipple Disease


Closed loop duodenal obstruction secondary to pancreatic carcinoma: a case report.

Comb Chem High Throughput Screen 2019 Apr 11. Epub 2019 Apr 11.

Department of Hepatobiliary Surgery, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing University, Shaoxing 312000. China.

Patients with pancreatic adenocarcinoma may develop into duodenal obstruction during the course of their disease. The diagnosis of obstruction can be generally achieved by means of imaging technologies. We reported a rare case of pancreatic tumor with duodenal obstruction accompanied by obstructive symptoms, which was finally confirmed by laparotomy. Read More

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http://dx.doi.org/10.2174/1386207322666190411112412DOI Listing
April 2019
1 Read

Pancreatic islet cell tumors in adolescents and young adults.

J Pediatr Surg 2019 Mar 27. Epub 2019 Mar 27.

Department of Surgery, University of Alabama at Birmingham, Children's of Alabama, Birmingham, AL. Electronic address:

Background: Pancreatic islet cell tumors are rare in adolescents, and most studies published to date focus on older patients. We utilized a national database to describe the histology and clinical pattern of pancreatic islet cell tumors in adolescent and young adult (AYA) patients, and to compare AYAs to older adults. We hypothesized that AYAs with pancreatic islet cell tumors would have better overall survival. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.01.060DOI Listing
March 2019
1 Read

Potential Role for Urine Polymerase Chain Reaction in the Diagnosis of Whipple Disease.

Clin Infect Dis 2019 Apr 4. Epub 2019 Apr 4.

Rheumatology Unit, CHU Brest, France.

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http://dx.doi.org/10.1093/cid/ciz094DOI Listing
April 2019
2 Reads

Whipple's endocarditis diagnosed by thrombus analysis retrieved by successful mechanical thrombectomy.

J Neurol Sci 2019 May 14;400:42-43. Epub 2019 Mar 14.

Stroke Unit, Department of Neurology, Hôpital Pierre Wertheimer, Lyon, France. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2019.03.009DOI Listing
May 2019
1 Read

Loss of the androgen receptor suppresses intrarenal calcium oxalate crystals deposition via altering macrophage recruitment/M2 polarization with change of the miR-185-5p/CSF-1 signals.

Cell Death Dis 2019 Mar 20;10(4):275. Epub 2019 Mar 20.

George Whipple Lab for Cancer Research, Departments of Pathology, Urology, and Radiation Oncology, and The Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, 14646, USA.

Crystals can trigger a wide range of kidney injuries that may link to the development of kidney stones. Infiltrating macrophages may influence hyperoxaluria-induced intrarenal calcium oxalate (CaOx) crystals deposition, yet their linkage to sex hormones remains unclear. Here we demonstrated that suppressing the androgen receptor (AR) expression in renal tubular epithelial cells increased the macrophage recruitment/M2 polarization that may result in enhancing the phagocytosis of intrarenal CaOx crystals. Read More

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http://dx.doi.org/10.1038/s41419-019-1358-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427030PMC
March 2019
1 Read

Tropheryma whipplei intestinal colonization in Italian and migrant population: a retrospective observational study.

Future Microbiol 2019 Mar 11;14:283-292. Epub 2019 Mar 11.

Centre for Tropical Diseases, IRCCS Sacro Cuore - Don Calabria Hospital, Via Sempreboni 5, 37024 Negrar, Italy.

Aim:  To obtain the first molecular epidemiological survey of Tropheryma whipplei intestinal colonization in Italy. Materials & methods: Retrospective, observational study to assess the prevalence of T. whipplei, the causative agent of Whipple's disease, in stool samples (real-time PCR) of patients attending the Center for Tropical Diseases (Italy) and risk factors associated. Read More

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http://dx.doi.org/10.2217/fmb-2018-0347DOI Listing
March 2019
2 Reads

Early Stage Biomarkers Screening of Prostate Cancer Based on Weighted Gene Coexpression Network Analysis.

DNA Cell Biol 2019 Mar 5. Epub 2019 Mar 5.

1 Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China.

Although the morbidity and mortality rates of prostate cancer (PCa) are considerably high, many PCas are characterized as indolent and slow growing, which do not require overtreatment. Overdiagnosis and overtreatment of early detected PCa are an emerging problem, owing to a lack of biomarkers that detect advanced disease at an earlier stage. In this study, RNA-Seq data of 57,045 genes for 495 PCa samples and 52 normal samples in the The Cancer Genome Atlas (TCGA) database were downloaded. Read More

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http://dx.doi.org/10.1089/dna.2018.4406DOI Listing
March 2019
5 Reads
2.055 Impact Factor

Whipple disease after bariatric surgery: from malabsorption to malnutrition status.

Nutr Hosp 2019 03;36(1):238-241

Center of Excellence for the Study and Treatment of the Obesity and Diabetes (CTO).

Introduction: Malabsorptive bariatric techniques are associated with nutritional deficiencies. However, when patients do not respond to supplemental intensive treatments they should be closely followed because they can hide other pathological conditions. We present the case of a 47-year-old man with morbid obesity (body mass index [BMI]: 48 kg/m2) who underwent bariatric surgery. Read More

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http://dx.doi.org/10.20960/nh.02258DOI Listing
March 2019
1 Read

Nissen Fundoplication-Preserving Laparoscopic Sleeve Gastrectomy.

Am Surg 2019 Feb;85(2):173-176

Gastroesophageal reflux disease (GERD) is significantly more prevalent in obese patients. Nissen fundoplication alleviates symptoms in those refractory to dietary changes and optimal medical management. The need for concomitant treatment of GERD and obesity is becoming more prevalent. Read More

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February 2019
5 Reads

Differences in Prognostic Factors and Recurrence Patterns after Curative-Intent Resection of Perihilar and Distal Cholangiocarcinomas.

Scand J Surg 2019 Feb 21:1457496919832150. Epub 2019 Feb 21.

2 Department of Transplantation and Liver Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Background:: Perihilar cholangiocarcinoma and distal cholangiocarcinoma arise from the same tissue but require different surgical treatment methods. It remains unclear whether these cholangiocarcinoma types have different outcomes, prognostic factors, and/or recurrence patterns.

Methods:: This retrospective study evaluated patients who underwent curative-intent resection for perihilar cholangiocarcinoma or distal cholangiocarcinoma at a tertiary academic hospital during 2000-2015. Read More

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http://dx.doi.org/10.1177/1457496919832150DOI Listing
February 2019
1 Read

[Diagnosis and surgical treatment of duodenal tumors].

Khirurgiia (Mosk) 2019(1):5-13

A.V. Vishnevsky Institute of Surgery, Moscow, Russia.

Aim: To present the experience in diagnosis and surgical treatment of duodenal tumors.

Material And Methods: The study included 27 patients with different duodenal tumors: adenocarcinoma (AC, n=8), gastrointestinal stromal tumor (GIST, n=13), neuroendocrine tumor (NET, n=6). The examination included computed tomography (in 27 patients), magnetic resonance imaging (12), transcutaneous ultrasound (14), endosonography (16), esophagogastroduodenoscopy (16). Read More

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http://www.mediasphera.ru/issues/khirurgiya-zhurnal-im-n-i-p
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http://dx.doi.org/10.17116/hirurgia20190115DOI Listing
January 2019
3 Reads

Early reoperation following pancreaticoduodenectomy: impact on morbidity, mortality, and long-term survival.

World J Surg Oncol 2019 Jan 31;17(1):26. Epub 2019 Jan 31.

Department of General Surgery B, Division of General Surgery, Tel-Aviv Sourasky, Medical Center, Affiliated with the Sackler Faculty of Medicine, Tel Aviv University, 6 Weizmann St., 64239, Tel-Aviv, Israel.

Background: Reoperation following PD is a surrogate marker for a complex post-operative course and may lead to devastating consequences. We evaluate the indications for early reoperation following PD and analyze its effect on short- and long-term outcome.

Methods: Four hundred and thirty-three patients that underwent PD between August 2006 and June 2016 were retrospectively analyzed. Read More

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http://dx.doi.org/10.1186/s12957-019-1569-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357503PMC
January 2019
6 Reads

Otosyphilis: Resurgence of an Old Disease.

Laryngoscope 2018 Dec 28. Epub 2018 Dec 28.

Department of Otolaryngology-Head and Neck Surgery, Harborview Medical Center, University of Washington School of Medicine, Seattle, Washington, U.S.A.

Objectives: To describe the clinical characteristics of patients presenting with a new diagnosis of otosyphilis over the past 10 years in a large, urban, safety-net hospital affiliated with a large county sexually transmitted disease clinic.

Methods: Retrospective case series. A chart review was performed of all patients who presented to an adult otolaryngology clinic with a new diagnosis of syphilis and hearing loss from January 2008 to December 2017. Read More

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http://dx.doi.org/10.1002/lary.27635DOI Listing
December 2018
2 Reads

Polypoid Undifferentiated Carcinoma With Osteoclast-like Giant Cells Arising in the Distal Common Bile Duct: A Rare Case Report.

Anticancer Res 2019 Jan;39(1):437-441

Department of Pathology, Mount Sinai Hospital, New York, NY, U.S.A.

Background: Undifferentiated carcinoma with osteoclast-like giant cells (UC-OGC) in distal common bile duct (CBD) is a rare entity.

Case Report: This case report describes a 45-year-old male with a history of a choledochal cyst status post partial excision and cholecystectomy who presented with a mass in the remaining distal/intrapancreatic common bile duct. It was initially mistaken for post-surgery hematoma; however, the rapid growth raised concern for malignancy, and prompted a pancreaticoduodenectomy (Whipple) procedure. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13131DOI Listing
January 2019
21 Reads

Minimal-invasive approach to pancreatoduodenectomy is associated with lower early postoperative morbidity.

Am J Surg 2019 Apr 19;217(4):718-724. Epub 2018 Apr 19.

Department of Surgery, University of California, San Francisco, USA; Department of Surgery, San Francisco VA Medical Center, USA. Electronic address:

Objectives: We aim to investigate the impact of the operation time for pancreatoduodenectomy (PD) in different surgical approaches.

Methods: The NSQIP database was used to examine the clinical data of patients underwent PD during 2014-2016.

Results: We sampled a total of 6151 patients who underwent elective PD. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2018.04.009DOI Listing
April 2019
15 Reads

Preoperative administration of the 5-HT4 receptor agonist prucalopride reduces intestinal inflammation and shortens postoperative ileus via cholinergic enteric neurons.

Gut 2018 Nov 24. Epub 2018 Nov 24.

Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium.

Objectives: Vagus nerve stimulation (VNS), most likely via enteric neurons, prevents postoperative ileus (POI) by reducing activation of alpha7 nicotinic receptor (α7nAChR) positive macrophages (mMφ) and dampening surgery-induced intestinal inflammation. Here, we evaluated if 5-HT4 receptor (5-HT4R) agonist prucalopride can mimic this effect in mice and human.

Design: Using Ca imaging, the effect of electrical field stimulation (EFS) and prucalopride was evaluated in situ on mMφ activation evoked by ATP in jejunal tissue. Read More

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http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2018-317263
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http://dx.doi.org/10.1136/gutjnl-2018-317263DOI Listing
November 2018
23 Reads

Ventricular global longitudinal strain is altered in children with sickle cell disease.

Br J Haematol 2018 Dec 19;183(5):796-806. Epub 2018 Nov 19.

Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA.

Cardiac disease is the primary cause of death in sickle cell disease (SCD). Right and left ventricular global longitudinal strain (RVGLS, LVGLS) are early markers of systolic dysfunction but are not well investigated among children with SCD. One hundred and forty-three patients with HbSS or HbSβ -thalassaemia (median age 11 years, range 5-19 years) and 71 controls matched for age and sex were compared. Read More

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http://doi.wiley.com/10.1111/bjh.15607
Publisher Site
http://dx.doi.org/10.1111/bjh.15607DOI Listing
December 2018
19 Reads

Whipple's Disease: A Well-Done Outcome to a Rare Disease.

Dig Dis Sci 2019 01;64(1):9-11

Department of Gastroenterology, Norfolk and Norwich University Hospital, Norwich, NR4 7UY, UK.

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http://dx.doi.org/10.1007/s10620-018-5342-7DOI Listing
January 2019
8 Reads

Histochemistry in the diagnosis of non-neoplastic gastrointestinal disorders.

Semin Diagn Pathol 2018 Nov 16;35(6):370-380. Epub 2018 Oct 16.

Department of Pathology, St. Jude Medical Center, Fullerton, CA 92835, United States. Electronic address:

The alimentary tract serves as host to a large number of diseases. In the non-neoplastic group of disorders, conventional histochemistry continues to play an important diagnostic role. It is particularly important in recognizing specific infectious diseases, such as Helicobacter gastritis, Whipple disease, intestinal tuberculosis and other forms of mycobacteriosis, malakoplakia, intestinal spirochetosis, fungal enteritides, amebiasis, cryptosporidiosis, isosporiasis, and microsporidiosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07402570183009
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http://dx.doi.org/10.1053/j.semdp.2018.10.002DOI Listing
November 2018
25 Reads

From Whipple Disease to Tropheryma whipplei Infection.

Authors:
Didier Raoult

Clin Infect Dis 2018 Oct 22. Epub 2018 Oct 22.

Aix Marseille Université, Institut de recherche pour le développement, Microbes Evolution Phylogenie Et Infections.

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http://dx.doi.org/10.1093/cid/ciy668DOI Listing
October 2018
4 Reads

Detection of Tropheryma whipplei in stool samples by one commercial and two in-house real-time PCR assays.

Trop Med Int Health 2019 Jan 8;24(1):101-108. Epub 2018 Nov 8.

Institute for Medical Microbiology, Virology and Hygiene, University Medicine Rostock, Rostock, Germany.

Objective: Tropheryma whipplei, the causative agent of Whipple's disease, can also be identified in stool samples of humans without systemic disease. It is much more frequently detected in human stool samples in tropical environments than in industrialized countries. PCR-screening has been applied for point prevalence studies and environmental assessments in tropical settings, but results depend on the applied assay. Read More

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http://dx.doi.org/10.1111/tmi.13172DOI Listing
January 2019
10 Reads

[F]FDG-PET for evaluating pediatric Rosai-Dorfman disease.

Pediatr Hematol Oncol 2018 Oct 22:1-4. Epub 2018 Oct 22.

e Division of Pediatric Hematology/Oncology, Department of Pediatrics , University of Mississippi Medical Center , Jackson , Mississippi , USA.

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http://dx.doi.org/10.1080/08880018.2018.1484828DOI Listing
October 2018
8 Reads

Systematic review of movement disorders and oculomotor abnormalities in Whipple's disease.

Mov Disord 2018 Nov 19;33(11):1700-1711. Epub 2018 Oct 19.

Movement Disorders Research Center, Toront Western Hospital, Toronto, Ontario, Canada.

Whipple's disease, affecting the CNS, can cause a wide variety of symptoms. Movement disorders are very prevalent, and some are pathognomonic of the disease. This systematic review analyzed all published cases of movement disorders because of CNS Whipple's disease, providing detailed information on clinical and associated features. Read More

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http://dx.doi.org/10.1002/mds.27419DOI Listing
November 2018
5 Reads

Ocular Whipple Disease: Report of Three Cases.

Ocul Immunol Inflamm 2018 Sep 7:1-4. Epub 2018 Sep 7.

c Advanced Eye Centre , Post Graduate Institute of Medical Education and Research , Chandigarh , India.

Purpose: To emphasize the different manifestations of ocular involvement in Whipple disease with challenge in establishing the diagnosis as clinical, laboratory, and histological features could mimic other uveitis entities.

Methods: Case reports of three patients.

Results: The first patient was an African male suffering from a chronic bilateral keratoconjunctitivitis that was initially misdiagnosed as a chronic allergic conjunctivitis. Read More

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http://dx.doi.org/10.1080/09273948.2018.1518461DOI Listing
September 2018
5 Reads

Bronchobiliary fistula: a rare complication after pancreaticoduodenectomy.

BMJ Case Rep 2018 Sep 4;2018. Epub 2018 Sep 4.

University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.

Biliary anatomic pathologies are rare disease occurrences that can result from a number of causes, most commonly iatrogenic, infectious and malignant aetiologies. Communications between the biliary and bronchial systems are even rarer and few cases have been documented in the literature. The present study describes a case of a 70-year-old man who underwent a pancreaticoduodenectomy (Whipple Procedure) as a curative procedure for an early stage neuroendocrine tumour. Read More

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http://dx.doi.org/10.1136/bcr-2017-221895DOI Listing
September 2018
33 Reads

Practical experience implementing supervised exercise therapy for peripheral artery disease in urban and rural Minnesota.

J Vasc Nurs 2018 09 29;36(3):157-159. Epub 2018 Jul 29.

School of Nursing, University of Minnesota, Minneapolis, Minnesota. Electronic address:

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http://dx.doi.org/10.1016/j.jvn.2018.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110094PMC
September 2018
3 Reads

Mesenteric lymphadenitis as a presenting feature of Whipple's disease: Value of PCR analysis.

Int J Infect Dis 2018 Oct 7;75:15-17. Epub 2018 Aug 7.

Department of Internal Medicine, Hôpital de la Croix Rousse, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, Lyon, France. Electronic address:

Whipple's disease (WD) is a rare chronic and systemic infection caused by the ubiquitous actinomycete Tropheryma whipplei. A case of localized infection with mesenteric adenopathy associated with a prolonged unexplained fever is reported herein. Screening by PCR on saliva and stool was positive, and T. Read More

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http://dx.doi.org/10.1016/j.ijid.2018.08.003DOI Listing
October 2018
47 Reads

Tropheryma whipplei Increases Expression of Human Leukocyte Antigen-G on Monocytes to Reduce Tumor Necrosis Factor and Promote Bacterial Replication.

Gastroenterology 2018 11 1;155(5):1553-1563. Epub 2018 Aug 1.

Aix Marseille Univ, IRD, APHM, MEPHI, IHU-Mediterranee Infection, Marseille, France. Electronic address:

Background & Aims: Infection with Tropheryma whipplei has a range of effects-some patients can be chronic carriers without developing any symptoms, whereas others can develop systemic Whipple disease, characterized by a lack a protective inflammatory immune response. Alterations in HLA-G function have been associated with several diseases. We investigated the role of HLA-G during T whipplei infection. Read More

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http://dx.doi.org/10.1053/j.gastro.2018.07.034DOI Listing
November 2018
8 Reads

Usefulness of polymerase chain reaction for diagnosing Whipple's disease in rheumatology.

PLoS One 2018 18;13(7):e0200645. Epub 2018 Jul 18.

Rheumatology Unit, Hôpital de la Cavale Blanche, Brest, France.

Objectives: To determine when Tropheryma whipplei polymerase chain reaction (PCR) is appropriate in patients evaluated for rheumatological symptoms.

Methods: In a retrospective observational study done in rheumatology units of five hospitals, we assessed the clinical and radiological signs that prompted T. whipplei PCR testing between 2010 and 2014, the proportion of patients diagnosed with Whipple's disease, the number of tests performed and the number of diagnoses according to the number of tests, the patterns of Whipple's disease, and the treatments used. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200645PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051605PMC
January 2019
9 Reads

Identification of putative drug targets and annotation of unknown proteins in Tropheryma whipplei.

Comput Biol Chem 2018 Oct 9;76:130-138. Epub 2018 Jun 9.

Molecular and Cellular Engineering Group, BioQuant, University of Heidelberg, Heidelberg, Germany; The Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology (HBIGS), University of Heidelberg, Heidelberg, Germany. Electronic address:

Tropheryma whipplei (T. whipplei) is the causative agent of Whipple's disease and blood culture-negative endocarditis. Due to the variability of symptoms, the disease is often poorly diagnosed. Read More

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http://dx.doi.org/10.1016/j.compbiolchem.2018.05.024DOI Listing
October 2018
22 Reads
1.120 Impact Factor

Diagnostic Approach for Classic Compared With Localized Whipple Disease.

Open Forum Infect Dis 2018 Jul 13;5(7):ofy136. Epub 2018 Jun 13.

Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota.

Background: Whipple disease (WD), a rare systemic infection caused by can be a diagnostic challenge due to its variable presentation. The role of polymerase chain reaction (PCR) is unclear as small bowel biopsy with Periodic acid-Schiff (PAS) staining remains the diagnostic gold standard. Individualized diagnostic approaches based on variable clinical manifestations are underutilized. Read More

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http://dx.doi.org/10.1093/ofid/ofy136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030902PMC
July 2018
4 Reads

Venting post-Whipple benign gastric outlet obstruction with temporary bilateral fully covered metal stents.

VideoGIE 2017 Dec 29;2(12):349-352. Epub 2017 Sep 29.

Digestive Disease Institute, Virginia Mason Medical Center, Seattle, Washington, USA.

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http://dx.doi.org/10.1016/j.vgie.2017.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003889PMC
December 2017
11 Reads

A Case of Whipple's Disease: A Very Rare Cause for Rapidly Progressive Dementia.

Indian J Psychol Med 2018 May-Jun;40(3):280-283

Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

Introduction: Whipple's disease (WD) is a very rare systemic disease caused by the gram-positive bacillus Tropherymawhippleii 1st described in the year 1907. It is a disease with multisystem involvement and high degree of suspicion is needed for diagnosis. However the classical (OMM)oculomasticatory (OFMM)oculofacial-skeletal myorhythmia clubbed with dementia, head ache and other neurologic features should deserve an attempt to confirm whenever possible and therapeutic trial as it is one of the treatable dementias. Read More

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http://dx.doi.org/10.4103/IJPSYM.IJPSYM_149_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968653PMC
June 2018
15 Reads

Isolierter zerebraler Morbus Whipple.

Rofo 2018 Nov 6;190(11):1059-1061. Epub 2018 Jun 6.

Institute of Radiology, University Hospital St. Pölten, Austria.

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http://dx.doi.org/10.1055/a-0581-5421DOI Listing
November 2018
4 Reads

Estrogen receptor β promotes renal cell carcinoma progression via regulating LncRNA HOTAIR-miR-138/200c/204/217 associated CeRNA network.

Oncogene 2018 09 23;37(37):5037-5053. Epub 2018 May 23.

Departments of Urology and Pathology, George Whipple Lab for Cancer Research, University of Rochester Medical Center, Rochester, NY, 14642, USA.

Recent studies indicated that the estrogen receptor beta (ERβ) could affect the progression of prostate and bladder tumors, however, its roles in the renal cell carcinoma (RCC), remain to be elucidated. Here, we provide clinical evidence that ERβ expression is correlated in a negative manner with the overall survival/disease-free survival in RCC patients. Mechanism dissection revealed that targeting ERβ with ERβ-shRNA and stimulating the transactivation of ERβ with 17β-estradiol or environmental endocrine disrupting chemicals, all resulted in altering the lncRNA HOTAIR expression. Read More

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http://dx.doi.org/10.1038/s41388-018-0175-6DOI Listing
September 2018
25 Reads

A comprehensive review and meta-analysis of risk factors for statin-induced myopathy.

Eur J Clin Pharmacol 2018 Sep 22;74(9):1099-1109. Epub 2018 May 22.

Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

Purpose: To aid prescribers in assessing a patient's risk for statin-induced myopathy (SIM), we performed a comprehensive review of currently known risk factors and calculated aggregated odds ratios for each risk factor through a meta-analysis.

Methods: This meta-analysis was done through four phases: (1) Identification of the relevant primary literature; (2) abstract screening using inclusion and exclusion criteria; (3) detailed review and data extraction; and (4) synthesis and statistical analysis.

Results: Out of 44 papers analyzed from 836 papers searched from MEDLINE, 18 different potential risk factors were collected, divided into three categories: three demographics (11 papers), ten clinical factors (31 papers), and five pharmacogenetics/biomarkers (12 papers). Read More

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http://dx.doi.org/10.1007/s00228-018-2482-9DOI Listing
September 2018
5 Reads

Atypical response of spondyloarthritis to biologics revealing Whipple's disease: A case-report.

Therapie 2018 Oct 3;73(5):437-439. Epub 2018 Mar 3.

Service de rhumatologie, CHRU de Nancy, bâtiment des spécialités médicales, site de Brabois, 545011 Vandœuvre lès Nancy, France.

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http://dx.doi.org/10.1016/j.therap.2018.02.008DOI Listing
October 2018
32 Reads

IgLON5-mediated neurodegeneration is a differential diagnosis of CNS Whipple disease.

Neurology 2018 Jun 16;90(24):1113-1115. Epub 2018 May 16.

From the Movement Disorders Unit, Neurology Department (H.M.-B., B.C., A.F.F., V.F.), Department of Immunology (M.-W.L., J.J.), and Department of Tissue Pathology and Diagnostic Oncology, ICPMR (W.V.), Westmead Hospital; Woolcock Institute of Medical Research (D.B., R.G.), Sydney Medical School (H.M.-B., A.F.F., V.F.), the University of Sydney; Douglass Hanly Moir Pathology (M.R.), New South Wales; and Neuroscience Research Australia (C.S.), Sydney, Australia.

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http://dx.doi.org/10.1212/WNL.0000000000005679DOI Listing
June 2018
7 Reads

EUS-guided hepaticoenterostomy as a portal to allow definitive antegrade treatment of benign biliary diseases in patients with surgically altered anatomy.

Gastrointest Endosc 2018 Sep 3;88(3):547-554. Epub 2018 May 3.

Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC, USA.

Background And Aims: EUS-guided hepaticoenterostomy (EUS-HE) usually is reserved for palliation of malignant biliary obstruction after failed endoscopic retrograde cholangiography (ERC) or inaccessible biliary tree in surgically altered anatomy (SAA). We describe the outcome of EUS-HE and antegrade therapy for benign biliary disease in patients with SAA.

Methods: Retrospective review of 20 consecutive patients with surgically altered anatomy and benign biliary obstruction who underwent EUS-HE performed by 1 endoscopist at a tertiary-care center over a 3-year period. Read More

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http://dx.doi.org/10.1016/j.gie.2018.04.2353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097896PMC
September 2018
27 Reads

[Movement disorders in a 32-year-old woman].

Rev Med Interne 2018 Jul 1;39(7):597-599. Epub 2018 May 1.

Service de médecine interne, hôpital Cochin, 27, rue du Faubourg-Saint-Jacques 75014 Paris, France.

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http://dx.doi.org/10.1016/j.revmed.2018.04.007DOI Listing
July 2018
8 Reads

Gamma delta T cell expansion in Whipple's disease with muscular granulomatous vasculitis.

Infection 2018 Aug 3;46(4):573-576. Epub 2018 May 3.

Department of Internal Medicine and Infectious Diseases, CHU Bordeaux, Hôpital Haut Lévèque, 33600, Pessac, France.

Whipple's disease usually presents as chronic joint pain followed by digestive manifestations. However, many different presentations have been described in the literature. We report here the first proven case of muscular vasculitis related to Whipple's disease, associated with an expansion of circulating activated γδ T lymphocytes. Read More

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http://dx.doi.org/10.1007/s15010-018-1143-3DOI Listing
August 2018
2 Reads

Whipple Disease Presenting as Cystic Brain Tumor: Case Report and Review of the Literature.

Turk Neurosurg 2018 ;28(3):495-499

Fattouma Bourguiba University Hospital, Department of Neurosurgery, Monastir, Tunisia.

Although neurological features are commonly encountered in Whipple"s disease (WD), presentation with purely neurological patterns is uncommon. Exclusive confinement to the central nervous system (CNS) is extremely rare. In these cases, the development of an isolated cerebral mass is exceptional. Read More

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http://dx.doi.org/10.5137/1019-5149.JTN.17111-16.2DOI Listing
August 2018
5 Reads

Cutaneous Metastasis of Adenocarcinoma of the Ampulla of Vater.

Am J Dermatopathol 2018 Oct;40(10):758-761

Department of Dermatology, Los Angeles Medical Center (LAMC), Southern California Kaiser Permanente, Los Angeles, CA.

Cutaneous metastases from an adenocarcinoma of the Ampulla of Vater are very rare, with only a few cases previously reported. We present here an additional case in a 57-year-old woman who complained of a painful growth on her frontal scalp that she had noticed 4 months earlier. Her medical history included an ampullary adenocarcinoma, which was diagnosed 4 years ago, excised through a Whipple procedure, and treated using chemotherapy and radiotherapy. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001155DOI Listing
October 2018
6 Reads

Chronic Pancreatitis: Diagnosis and Treatment.

Authors:
Kathleen Barry

Am Fam Physician 2018 Mar;97(6):385-393

University of Texas Health Science Center at Houston, Houston, TX, USA.

Chronic pancreatitis is an irreversible and progressive disorder of the pancreas characterized by inflammation, fibrosis, and scarring. Exocrine and endocrine functions are lost, often leading to chronic pain. The etiology is multifactorial, although alcoholism is the most significant risk factor in adults. Read More

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March 2018
12 Reads

Back from the brink of obscurity.

Authors:
Donald C Vinh

Elife 2018 04 18;7. Epub 2018 Apr 18.

Department of Medicine, McGill University Health Centre, Montreal, Canada.

A mutation in a transcription factor makes people susceptible to , the bacterium that causes a rare condition called Whipple's disease. Read More

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http://dx.doi.org/10.7554/eLife.36649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906093PMC
April 2018
51 Reads

CNS Langerhans cell histiocytosis: Common hematopoietic origin for LCH-associated neurodegeneration and mass lesions.

Cancer 2018 Jun 6;124(12):2607-2620. Epub 2018 Apr 6.

Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.

Background: Central nervous system Langerhans cell histiocytosis (CNS-LCH) brain involvement may include mass lesions and/or a neurodegenerative disease (LCH-ND) of unknown etiology. The goal of this study was to define the mechanisms of pathogenesis that drive CNS-LCH.

Methods: Cerebrospinal fluid (CSF) biomarkers including CSF proteins and extracellular BRAFV600E DNA were analyzed in CSF from patients with CNS-LCH lesions compared with patients with brain tumors and other neurodegenerative conditions. Read More

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http://dx.doi.org/10.1002/cncr.31348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289302PMC
June 2018
29 Reads
4.890 Impact Factor

Synchronous Pancreatic Serous Cystic Neoplasm and Duodenal Neuroendocrine Tumor: Case Report and Review of the Literature.

Int J Surg Pathol 2018 Sep 6;26(6):551-557. Epub 2018 Apr 6.

1 Department of Pathology, Odense University Hospital, Odense, Denmark.

Simultaneous presence of pancreatic serous cystic neoplasms and neuroendocrine neoplasms is rare. We present a case with the incidental finding of a duodenal neuroendocrine tumor (NET) with 2 lymph node metastases in a Whipple resection specimen performed to remove a pancreatic cystic neoplasm that postoperatively turned out to represent a serous cystic neoplasm (SCN). The patient was a 75-year-old female. Read More

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http://journals.sagepub.com/doi/10.1177/1066896918766245
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http://dx.doi.org/10.1177/1066896918766245DOI Listing
September 2018
10 Reads