2,832 results match your criteria Whipple Disease


Coronavirus (COVID-19): Patient experience-Administrative services on the frontline during crisis.

Head Neck 2020 May 16. Epub 2020 May 16.

Department of Patient Experience, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.

The COVID-19 pandemic has had a dramatic impact on care delivery among health care institutions and providers in the United States. As a categorical cancer center, MD Anderson has prioritized care for our patients based on acuity of their disease. We continue to implement measures to protect patients and employees from acquiring the infection within our facilities, and to provide acute management of cancer patients with concomitant COVID-19 infections who are considered at high risk of death. Read More

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http://dx.doi.org/10.1002/hed.26259DOI Listing

Ampullary stenosis and choledocholithiasis post Roux-En-Y gastric bypass: challenges of biliary access and intervention.

HPB (Oxford) 2020 Apr 24. Epub 2020 Apr 24.

University of California San Francisco, Department of Surgery, 513 Parnassus Avenue S-321, San Francisco, CA, 94143-0470, United States; San Francisco Veterans Affairs Medical Center, Department of Surgery, 4150 Clement Street, Box 112, San Francisco, CA, 94121, United States. Electronic address:

Background: Ampullary stenosis following Roux-en-Y gastric bypass (RYGB) is increasingly encountered. We describe cases of biliary obstruction from ampullary stenosis and choledocholithiasis to illustrate the associated diagnostic and interventional challenges with this condition.

Methods: We reviewed medical records of patients with prior RYGB who underwent a biliary access procedure or surgery for non-malignant disease from January 2012-December 2018. Read More

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http://dx.doi.org/10.1016/j.hpb.2020.02.004DOI Listing

Robotic pancreaticoduodenectomy may offer improved oncologic outcomes over open surgery: a propensity-matched single-institution study.

Surg Endosc 2020 Apr 23. Epub 2020 Apr 23.

Division of HPB Surgery, Department of General Surgery, Carolinas Medical Center, Charlotte, NC, USA.

Background: The robotic platform in pancreatic disease has gained popularity in the hepatobiliary community due to significant advantages it technically offers over conventional open and laparoscopic techniques. Despite promising initial studies, there remains scant literature on operative and oncologic outcomes of robotic pancreaticoduodenectomy (RPD) for pancreatic adenocarcinoma.

Methods: A retrospective review evaluated all RPD performed for pancreatic adenocarcinoma from 2008 to 2019 in a single tertiary institution. Read More

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http://dx.doi.org/10.1007/s00464-020-07564-xDOI Listing

Combined Modality Treatment With Brentuximab Vedotin and Radiation Therapy for Primary Cutaneous Anaplastic Large Cell Lymphoma: A Case Report.

J Hematol 2019 Sep 30;8(3):132-136. Epub 2019 Sep 30.

Department of Medicine, Division of Medical Oncology and Hematology, Mayo Clinic Health System, 1221 Whipple St., Eau Claire, WI, 54703, USA.

Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare form of non-Hodgkins lymphoma. Current frontline treatments for pcALCL include surgical resection, anthracycline-based chemotherapy, and/or radiation therapy (RT) depending on disease severity. While brentuximab vedotin (BV) has been used for refractory/relapsed cases, it recently received Food and Drug Administration (FDA) approval for use in combination with chemotherapy for peripheral T-cell lymphomas. Read More

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http://dx.doi.org/10.14740/jh534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153663PMC
September 2019

Development of a pediatric Lyme meningitis symptom measurement instrument using a Delphi technique.

Ticks Tick Borne Dis 2020 Mar 23:101418. Epub 2020 Mar 23.

Division of Emergency Medicine, Harvard Medical School; Boston, MA and Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, USA.

Published Lyme meningitis treatment studies are limited by outcome measures that cannot capture day-to-day differences in clinical improvement. Our goal was to use expert consensus to develop a daily measurement instrument for assessing clinical improvement in children with Lyme meningitis. We assembled a panel of 24 nationally recognized Lyme disease experts to develop a pediatric daily symptom measurement instrument. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2020.101418DOI Listing

Influence of Changes in Sedentary Time on Outcomes of Supervised Exercise Therapy in Individuals with Comorbid Peripheral Artery Disease and Type 2 Diabetes.

Ann Vasc Surg 2020 Apr 9. Epub 2020 Apr 9.

School of Nursing, University of Minnesota - Twin Cities, Minneapolis, MN.

Background: Although supervised exercise therapy (SET) is effective in improving walking distance among adults with symptomatic peripheral artery disease (PAD), some research suggests that individuals with comorbid PAD and type 2 diabetes mellitus (T2DM) may experience a blunted response to SET. It is unknown whether free-living sedentary time changes during SET, and if increases in sedentary time could, in part, explain poor response to SET. The purposes of this pilot study were to (1) determine if older adults with PAD (with and without T2DM) engaging in SET change their sedentary behavior and (2) examine the relationship between changes in sedentary behavior and SET outcomes. Read More

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http://dx.doi.org/10.1016/j.avsg.2020.03.040DOI Listing

Diagnosis of Flier's syndrome in a patient with nondiabetic hypoglycemia: a case report and critical appraisal of the literature.

Endocrine 2020 Apr 9. Epub 2020 Apr 9.

Department of Translational Medicine, Federico II University of Naples and URT "Genomic of Diabetes" of Institute of Experimental Endocrinology and Oncology, National Council of Research (CNR), Naples, Italy.

Purpose: Autoimmune hypoglycemia includes rare syndromes characterized by the presence of either anti-insulin antibodies (IAA) (Hirata's disease) or anti-insulin receptor (anti-ISR) antibodies (Flier's syndrome). Diagnosis is usually based on identification of the specific antibodies, in presence of the Whipple triad. However, most of these cases are classified as idiopathic diseases due to the difficulty to define the pathogenic culprit. Read More

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http://dx.doi.org/10.1007/s12020-020-02287-4DOI Listing

Trends in survival based on treatment modality in patients with pancreatic cancer: a population-based study.

Curr Oncol 2020 Feb 1;27(1):e1-e8. Epub 2020 Feb 1.

Health Research Methods, Evidence, and Impact.

Background: Pancreatic cancer (pcc) is one of the most lethal types of cancer, and surgery remains the optimal treatment modality for patients with resectable tumours. The objective of the present study was to examine and compare trends in the survival rate based on treatment modality in patients with pcc.

Methods: This population-based retrospective analysis included all patients with known-stage pcc in Ontario between 2007 and 2015. Read More

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http://dx.doi.org/10.3747/co.27.5211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096205PMC
February 2020

Unusual effectiveness of systemic steroids in Whipple disease.

Pulmonology 2020 Mar 16. Epub 2020 Mar 16.

University Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, Italy; Clinical and Experimental Medicine PhD Program, University of Modena Reggio Emilia, Italy.

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http://dx.doi.org/10.1016/j.pulmoe.2020.02.007DOI Listing

Recurrent pancreatic cancer patient treated by chemotherapy and focused ultrasound surgery. A case report.

Med Ultrason 2020 May 15;22(2):247-249. Epub 2019 Aug 15.

Clinical Center for Tumor Therapy of the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

We present a case of recurrent pancreatic cancer diagnosed by computer tomography (CT) and positron emission tomography(PET), 7 months after Whipple radical surgery in a 61-year-old female patient. The patient was successfully treated byfocused ultrasound surgery (FUS) by innovative high intensity focused ultrasound device. The patient had no complications. Read More

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http://dx.doi.org/10.11152/mu-2031DOI Listing

The discriminative properties of erythrocyte anisocytosis in patients with resectable malignant pancreatic masses compared with an age and gender matched control group.

Authors:
O M Akturk M Çakir

G Chir 2020 Jan-Feb;41(1):34-39

Introduction: Red cell distribution width (RDW) is a parameter that reflects the heterogeneity in the size of the circulating erythrocytes. Elevated levels of RDW have been found related to various pathologic conditions including cancers. We hypothesized that elevated RDW levels might correspond to advanced stages of pancreatic cancer. Read More

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February 2020

Plasma cells and lymphoid aggregates in sleeve gastrectomy specimens: Normal or gastritis?

Medicine (Baltimore) 2020 Feb;99(6):e18926

Department of Pathology and Laboratory Medicine.

Lymphoid follicles/aggregates in gastric biopsies have been traditionally linked to Helicobacter pylori gastritis, and less commonly to other inflammatory and neoplastic conditions. The frequency of such aggregates in normal stomachs has yet to be adequately evaluated. This is especially relevant when it comes to diagnosing non-specific chronic gastritis in biopsy specimens with chronic inflammation but no evidence of H pylori infection. Read More

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http://dx.doi.org/10.1097/MD.0000000000018926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015648PMC
February 2020

Pearls & Oy-sters: A rare presentation of Whipple disease: Still waters run deep.

Neurology 2020 02 3;94(7):e758-e761. Epub 2020 Feb 3.

From the Department of Neurology (A.T.K.), Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam; Department of Neurology (J.R.P., K.S.A.), OLVG Hospital, Amsterdam; Department of Neurology (J.R.P., K.S.A.), Zaans Medisch Centrum, Zaandam; and Department of Viroscience (K.S.A.), Erasmus MC, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1212/WNL.0000000000008976DOI Listing
February 2020

Cerebral Revascularization for Moyamoya Syndrome Associated with Sickle Cell Disease: A Systematic Review of the Literature on the Role of Extracranial-Intracranial Bypass in Treating Neurologic Manifestations of Pediatric Patients with Sickle Cell Disease.

World Neurosurg 2020 May 31;137:62-70. Epub 2020 Jan 31.

Department of Neurosurgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA. Electronic address:

Moyamoya syndrome (MMS) in patients with sickle cell disease (SCD) accentuates the risk of recurrent strokes. Chronic transfusion therapy (CTT) is an excellent option for preventing recurrent strokes in most patients with SCD. In SCD with MMS, CTT may fail as a long-term solution. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.01.182DOI Listing

Chronic bursitis and tenosynovitis revealing Whipple's disease.

Joint Bone Spine 2020 Jan 30. Epub 2020 Jan 30.

Department of Rheumatology, CHU Clermont ferrand, 58 rue Montalembert, 63003 Clermont Ferrand Cedex 1, France.

Joint complaints, most commonly intermittent arthritis, are the initial manifestation in about three-fourths of Whipple's disease cases. We herein report on two cases wherein Whipple's disease manifested itself as chronic bursitis and tenosynovitis at several sites. A 42 year-old man had bilateral olecranon bursitis, a right patellar bursitis and an extensor tenosynovitis on the left wrist and a 54 year-old man had extensor tenosynovitis at both wrists and a bilateral tenosynovitis of the extensors at both ankle. Read More

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http://dx.doi.org/10.1016/j.jbspin.2020.01.010DOI Listing
January 2020

Thrombocytopenia and endocarditis in a patient with Whipple's disease: case report.

BMC Infect Dis 2020 Jan 22;20(1):71. Epub 2020 Jan 22.

Division of Academic Affairs and Research, Orlando Regional Healthcare, 1401 Lucerne Terrace, 2nd floor, Orlando, Fl, 32806, USA.

Background: Whipple's disease (WD) is a rare multisystem infectious disorder that is caused by the actinomycete Tropheryma whipplei. It presents with joint pain followed by abdominal pain, diarrhea, malabsorption and finally failure to thrive. Diagnosis requires tissue sampling and histology with periodic acid-Schiff [PAS] staining. Read More

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http://dx.doi.org/10.1186/s12879-020-4799-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977297PMC
January 2020

Sudden 'cure' of type two diabetes due to pancreatic insulinoma: A case report.

Mol Clin Oncol 2020 Feb 3;12(2):174-178. Epub 2019 Dec 3.

Department of Endocrinology and Diabetes, Hellenic Red Cross Hospital, 11526 Athens, Greece.

Insulinomas are rare tumors of the islet cells of the pancreas and are the most common cause of endogenous hyperinsulinism. Although they usually present with symptoms of hypoglycemia, sometimes they can have vague symptoms. We present the case of a 62-year-old diabetic female who was diagnosed with a large insulinoma after being investigated for the 'cure' of her diabetes. Read More

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http://dx.doi.org/10.3892/mco.2019.1957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951228PMC
February 2020

Hepaticojejunostomy for Benign Disease: Long-Term Stricture Rate and Management.

Am Surg 2019 Dec;85(12):1350-1353

‡Division of Abdominal Transplantation, Department of Surgery, Rush University Medical Center, Chicago, Illinois.

The objective of the study was to determine the long-term stricture rate of hepaticojejunostiomy (HJ) performed for benign disease, to compare stricture rates for transplant patients and nontransplant patients, and to compare the success rates of procedural and surgical treatment options. Hospital charts of 135 consecutive patients undergoing HJ between 1998 and 2016 were analyzed retrospectively. The primary outcome was stricture formation. Read More

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December 2019

Liposomal Irinotecan + 5-FU/LV in Metastatic Pancreatic Cancer: Subgroup Analyses of Patient, Tumor, and Previous Treatment Characteristics in the Pivotal NAPOLI-1 Trial.

Pancreas 2020 01;49(1):62-75

Washington University in St. Louis, St. Louis, MO.

Objectives: The NAnoliPOsomaL Irinotecan (NAPOLI-1) study (NCT01494506) was the largest global phase 3 study in a post-gemcitabine metastatic pancreatic adenocarcinoma (mPAC) population (N = 417). The subanalyses reported here investigated the prognostic effect of tumor characteristics and disease stage, prior treatment characteristics, baseline patient characteristics on survival outcomes in NAPOLI-1, and whether liposomal irinotecan (nal-IRI) + 5-fluorouracil/leucovorin (5-FU/LV) benefited patients with mPAC across subgroups.

Methods: Post hoc analyses were performed in the NAPOLI-1 population (4 across tumor characteristics and disease stage, 6 across prior treatment characteristics, and 4 across patient baseline characteristics). Read More

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http://dx.doi.org/10.1097/MPA.0000000000001455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946097PMC
January 2020

Statin therapy does not influence the outcome of patients undergoing surgery for pancreatic cancer.

ANZ J Surg 2019 Dec 17. Epub 2019 Dec 17.

Department of Hepatobiliary and Pancreatic Surgery, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK.

Background: Recently, statins have been associated with improved survival in certain cancers. The aim of this study was to evaluate the impact of statins on the outcome of patients undergoing surgery for pancreatic cancer. In addition, the effect of statins on the histopathological characteristics of the disease was assessed. Read More

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http://dx.doi.org/10.1111/ans.15600DOI Listing
December 2019

Mixed serous-neuroendocrine neoplasm of the pancreas: A case report and review of the literature.

World J Clin Cases 2019 Dec;7(23):4119-4129

Department of Pathology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu Province, China.

Background: Pancreatic mixed serous-neuroendocrine neoplasms (MSNNs) are mixed tumors containing two components with different pathologies, namely, pancreatic serous cystic neoplasm (PSCN) and pancreatic neuroendocrine tumor (PanNET). For MSNNs, diffuse PSCN involving the whole pancreas is extremely rare, with only eight previous case reports.

Case Summary: A 45-year-old Chinese woman, with a free previous medical history and no obvious symptoms, was found to have a pancreatic neoplasm and admitted to our hospital for further diagnosis in March 2018. Read More

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http://dx.doi.org/10.12998/wjcc.v7.i23.4119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906574PMC
December 2019

Obesity and surgical complications of pancreaticoduodenectomy: An observation study utilizing ACS NSQIP.

Am J Surg 2019 Oct 25. Epub 2019 Oct 25.

State University of New York Downstate Medical Center, Department of Surgery, Brooklyn, NY, USA; Zucker School of Medicine at Hofstra Northwell, Department of Surgery, Hempstead, NY, USA.

Background: An estimated 38% of US adults are obese. Obesity is associated with socioeconomic disparities and increased rates of comorbidities, and is a known risk factor for development of pancreatic cancer. As a fourth leading cause of death in the United States, pancreatic cancer is commonly treated with a pancreatico-duodenectomy (PD), or Whipple procedure. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2019.10.030DOI Listing
October 2019
2.291 Impact Factor

Seronegative Arthritis and Whipple Disease: Risk of Misdiagnosis in the Era of Biologic Agents.

Case Rep Rheumatol 2019 13;2019:3410468. Epub 2019 Oct 13.

Rheumatology Clinic, Department of Medical Area, Academic Hospital Santa Maria della Misericordia, University of Udine, Udine, Italy.

We report 2 cases of Whipple disease (WD), previously diagnosed as seronegative polyarthritis and treated for several years with immunosuppressive agents, accordingly. Both cases had been treated over years with cDMARDs and bDMARDs. The first patient was a 48-year-old male, who developed a life-threatening disease characterized by fever, significant weight loss, and bloody diarrhoea, supported with RBC transfusions. Read More

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http://dx.doi.org/10.1155/2019/3410468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815603PMC
October 2019

Gemcitabine-induced pseudocellulitis: a case report and review of the literature.

Curr Oncol 2019 10 1;26(5):e703-e706. Epub 2019 Oct 1.

Schulich School of Medicine and Dentistry, London Regional Cancer Program, London, ON.

Gemcitabine is a chemotherapeutic agent used in a wide variety of solid tumours. Known side effects include a dose-limiting myelosuppressive toxicity, mild rash, and radiation-dependent dermatitis. Rarely, localized inflammation in the form of pseudocellulitis has also been observed. Read More

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http://dx.doi.org/10.3747/co.26.5007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821114PMC
October 2019

Freiburg Neuropathology Case Conference : A Progressive Lesion of the Optic Tract, Brainstem, Hypothalamus and Basal Ganglia.

Clin Neuroradiol 2019 Dec;29(4):797-804

Department of Neuropathology, Medical Centre, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1007/s00062-019-00849-2DOI Listing
December 2019

Prognostic value of positive surgical margins after resection of cholangiocarcinoma. Experience at a high-volume hospital center specializing in hepatopancreatobiliary surgery.

Rev Gastroenterol Mex 2020 Jan - Mar;85(1):18-24. Epub 2019 Nov 1.

Departamento de Cirugía Hepatopancreatobiliar, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Ciudad de México, México. Electronic address:

Introduction And Aims: Cholangiocarcinoma accounts for 3% of gastrointestinal tumors and is the second most frequent hepatic neoplasia after hepatocellular carcinoma. The primary aim was to evaluate the median disease-free period and survival in patients with cholangiocarcinoma diagnosis through the comparison of R0 and R1 resection margins.

Material And Methods: A retrospective analysis was conducted on 36 patients that underwent some type of surgical resection due to cholangiocarcinoma diagnosis, within the time frame of 2000-2017, at a center specializing in hepatopancreatobiliary surgery. Read More

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http://dx.doi.org/10.1016/j.rgmx.2018.11.011DOI Listing
November 2019
1 Read

Wither Away: Weight Loss and Persistent Inflammation in a Woman With Whipple Disease.

Am J Med 2019 Oct 31. Epub 2019 Oct 31.

Division of Internal Medicine, University Hospital Basel, Basel, Switzerland; Department of Clinical Research, University Basel, Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2019.08.058DOI Listing
October 2019

Piloting Electronic Case Reporting for Improved Surveillance of Sexually Transmitted Diseases in Utah.

Online J Public Health Inform 2019 19;11(2):e7. Epub 2019 Sep 19.

Utah Department of Health, Salt Lake City, UT, USA.

Objectives: The Utah Department of Health (UDOH) developed an electronic case reporting (eCR) process to automatically transfer clinical data from a provider to the state health department, with aims of improving sexually transmitted disease (STD) surveillance data quality, decreasing the time spent on STD case investigations, and expanding the process to other diseases and larger healthcare systems.

Methods: Reportable Conditions Trigger Codes (RCTC) were placed into the electronic health record (EHR) system at Planned Parenthood Association of Utah (PPAU) to trigger the automatic transfer of clinical data to Utah's public health surveillance system. Received data were de-duplicated, processed, and assigned directly to the public health surveillance system, with minimal manual intervention. Read More

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http://dx.doi.org/10.5210/ojphi.v11i2.9733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788887PMC
September 2019

Diagnostic vitrectomy: a case series in a single referral center.

Arch Soc Esp Oftalmol 2019 Nov 9;94(11):529-535. Epub 2019 Oct 9.

Clinic Institute of Ophthalmology (ICOF), Clinic Hospital of Barcelona, Barcelona, España.

Objective: To study the results and safety of diagnostic vitrectomy in patients with unknown etiology panuveitis.

Methods: A retrospective descriptive observational study was carried out in which a total of 29 patients (37 eyes) were included, who underwent a vitreous biopsy due to acute intraocular inflammatory processes. In all, demographic and clinical data were collected. Read More

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http://dx.doi.org/10.1016/j.oftal.2019.07.017DOI Listing
November 2019
1 Read

Modified Whipple on an 18-month-old with traumatic pancreatic transection and duodenal rupture.

Trauma Case Rep 2019 Oct 29;23:100241. Epub 2019 Aug 29.

Spartanburg Regional Healthcare System, United States of America.

The emergence of the Whipple procedure revolutionized operative management of pancreatic disease since its introduction (Fernandez-del Castillo et al., 2012 [1]). This operation classically involves removal of the head of the pancreas along with the duodenum, gallbladder, a portion of the bile duct, and part of the stomach (Warshaw and Thayer, 2004; Evans et al. Read More

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http://dx.doi.org/10.1016/j.tcr.2019.100241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727103PMC
October 2019
2 Reads

Cytologic identification of fungal arthritis in a Labrador Retriever with disseminated Talaromyces helicus infection.

Vet Clin Pathol 2019 Sep 11;48(3):449-454. Epub 2019 Sep 11.

Department of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.

An 8-year-old, neutered male Labrador Retriever presented with acute forelimb lameness. Clinical signs progressed over one week. On physical examination, right cubital joint effusion and bilateral axillary lymphadenomegaly were noted, and severe internal lymphadenomegaly was observed ultrasonographically. Read More

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http://dx.doi.org/10.1111/vcp.12777DOI Listing
September 2019
1 Read

Patients' treatment preferences for potentially resectable tumors of the head of the pancreas.

HPB (Oxford) 2020 Feb 6;22(2):265-274. Epub 2019 Sep 6.

University of Pittsburgh Medical Center, United States.

Background: The primary aim of this study was to assess if patients with potentially resectable ductal adenocarcinoma (PDAC) of the head of the pancreas would choose a Whipple procedure versus palliative chemotherapy.

Methods: A cohort of adults with radiological resectable PDAC was enrolled at a tertiary Canadian teaching hospital. Participants were informed about treatment options, expected outcomes, and adverse events using data from the most recent scientific literature. Read More

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http://dx.doi.org/10.1016/j.hpb.2019.06.015DOI Listing
February 2020
3 Reads

The Path to Whipple Reconstruction for Pancreatic Adenocarcinoma: Trans-Mesocolon or Through Ligament of Treitz?

J Gastrointest Surg 2019 Aug 29. Epub 2019 Aug 29.

Division of Surgical Oncology, Department of Surgery, Winship Cancer Institute, Emory University, 1365C Clifton Road NE, 2nd Floor, Atlanta, GA, 30322, USA.

Background: The path of the biliopancreatic limb for reconstruction of the pancreatic anastomosis during pancreatoduodenectomy for pancreatic ductal adenocarcinoma can be trans-mesocolon or through the ligament of Treitz. Even after curative intent pancreatoduodenectomy, incidence of recurrence in the surgical bed remains high and may lead to obstruction of the biliopancreatic limb. However, the association between path of jejunal limb and incidence of biliopancreatic limb obstruction has not been studied. Read More

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http://dx.doi.org/10.1007/s11605-019-04377-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048634PMC
August 2019
1 Read

Primary Whipple disease of the Central Nervous System presenting with rhombencephalitis.

Int J Infect Dis 2019 Nov 23;88:149-151. Epub 2019 Aug 23.

Infectious Diseases Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Italy.

Primary Whipple disease of the Central Nervous System is a rare entity whose outcome might be fatal if not promptly diagnosed and treated. Few cases are reported in the literature with heterogeneous clinical and radiological presentations which often make the diagnosis extremely challenging. We report a case of primary Whipple disease of the Central Nervous System presenting with rhombencephalitis in a female patient in immunosuppressive treatment for rheumatoid arthritis. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.08.019DOI Listing
November 2019
2 Reads

Autoimmune pancreatitis masquerading as carcinoma head of pancreas: A case report and review of literature.

Ann Med Surg (Lond) 2019 Sep 28;45:82-85. Epub 2019 Jul 28.

Department of Pathology, Pt. B D Sharma PGIMS, Rohtak, India.

Introduction: Autoimmune pancreatitis (AIP) is a rare form of chronic inflammatory pancreatic disease secondary to an underlying autoimmune mechanism. It is now considered as pancreatic manifestation of IgG4 related disease, which is a multisystem disease.

Case Report: We are reporting a patient who presented with obstructive jaundice and mass head of pancreas on Computed Tomography (CT) scan. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S20490801193009
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http://dx.doi.org/10.1016/j.amsu.2019.07.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698257PMC
September 2019
6 Reads

Efferent Loop Syndrome in a Post-pancreatoduodenectomy Patient Due to Exuberant Foreign Body Giant Cell Reaction Mimicking Cancer: A Case Report.

Cureus 2019 Jun 14;11(6):e4904. Epub 2019 Jun 14.

Surgery, Dow University of Health Sciences, Karachi, PAK.

Efferent loop syndrome has been rarely reported after pancreatoduodenectomy. In those cases that have been reported, the majority presented late and recurrence or peritoneal metastases were found to be the usual causes. Foreign body giant cell reactions (FBGCR) also rarely develop into masses that are large enough to cause problems or mimic malignancy. Read More

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https://www.cureus.com/articles/16231-efferent-loop-syndrome
Publisher Site
http://dx.doi.org/10.7759/cureus.4904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689478PMC
June 2019
4 Reads

Implications of Prolonged Time to Pancreaticoduodenectomy After Neoadjuvant Chemoradiation.

J Surg Res 2020 01 8;245:51-56. Epub 2019 Aug 8.

Division of Surgical Oncology, Trihealth Cancer Institute, Cincinnati, Ohio. Electronic address:

Background: For patients with pancreatic adenocarcinoma (PA), the optimal time interval between neoadjuvant chemoradiation (CR) to surgical resection has not been well established.

Methods: The National Cancer Database from 2006 to 2014 was queried for patients ≥18 y old diagnosed with PA who received neoadjuvant CR. Survival and short-term outcomes were compared between patients who had pancreaticoduodenectomy ≤12 wk and >12 wk after completion of CR. Read More

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http://dx.doi.org/10.1016/j.jss.2019.07.024DOI Listing
January 2020
3 Reads

Challenges in the management of adenocarcinoma of ampulla of Vater in pregnancy: A case report and review of literature.

Int J Surg Case Rep 2019 26;61:38-43. Epub 2019 Jun 26.

Department of General Surgery, King Fahad Specialist Hospital, Dammam, Saudi Arabia.

Introduction: Ampullary adenocarcinoma is a rare entity during pregnancy. It accounts for 0.5% of all gastrointestinal malignancies. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.06.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626975PMC
June 2019
3 Reads

Fatal Whipple's disease with severe mental manifestations on relapse - case report and brief advances update.

Rom J Morphol Embryol 2019 ;60(1):319-323

Department of Pathology, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania;

We present the case of a 51-year-old male admitted for asthenia, fatigability, nausea, inappetence, weight loss, watery diarrhea, lower limb paresthesia and diagnosed after further investigations with Whipple's disease (WD). The evolution was favorable under antibiotic therapy but after a period of time the patient was no longer compliant to the treatment and psychotic manifestations, general status alteration and finally the decease occurred. WD is a condition caused by Tropheryma whipplei (TW) bacterium in people with altered macrophage degrading capacity and it is lethal without early treatment. Read More

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December 2019
1 Read

Surgical management of familial adenomatous polyposis: pancreas-sparing duodenectomy or pancreaticoduodenectomy (Whipple procedure).

Rev Esp Enferm Dig 2019 07;111(7):572-573

Cirugía General y del Aparato Digestivo, Hospital Universitario Ramón y Cajal, España.

Duodenal cancer is the main cause of death for patients with FAP syndrome (familial adenomatous polyposis) treated with a colectomy. The disease follows the adenoma to carcinoma sequence and is diagnosed during follow-up in 7-36% of patients. Endoscopic treatment is used during the first treatment stage of the disease and surgery is an adequate therapeutic option when endoscopic control is insufficient. Read More

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http://dx.doi.org/10.17235/reed.2019.6096/2018DOI Listing
July 2019
4 Reads

ASC-J9® increases the bladder cancer chemotherapy efficacy via altering the androgen receptor (AR) and NF-κB survival signals.

J Exp Clin Cancer Res 2019 Jun 24;38(1):275. Epub 2019 Jun 24.

Sex Hormone Research Center and Department of Urology, China Medical University/Hospital, Taichung, 404, Taiwan.

Background: The current chemotherapy regimens may extend survival for patients with metastatic bladder cancer (BCa) for a few months, but eventually most patients succumb to disease because they develop resistance to their chemotherapy.

Methods: TCGA human clinical sample survey and urothelial tumor tissue microarrays (TMAs) were applied to investigate the expression of androgen receptor (AR) and NF-κB. Multiple BCa cell lines were used to test chemotherapy's efficacy via multiple assays including XTT, flow cytometry, TUNEL, and BrdU incorporation. Read More

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http://dx.doi.org/10.1186/s13046-019-1258-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592003PMC
June 2019
6 Reads

Surgical Outcomes After Pancreatic Resection of Screening-Detected Lesions in Individuals at High Risk for Developing Pancreatic Cancer.

J Gastrointest Surg 2020 May 13;24(5):1101-1110. Epub 2019 Jun 13.

Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD, USA.

Background: Screening high-risk individuals (HRI) can detect potentially curable pancreatic ductal adenocarcinoma (PDAC) and its precursors. We describe the outcomes of high-risk individuals (HRI) after pancreatic resection of screen-detected neoplasms.

Methods: Asymptomatic HRI enrolled in the prospective Cancer of the Pancreas Screening (CAPS) studies from 1998 to 2014 based on family history or germline mutations undergoing surveillance for at least 6 months were included. Read More

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http://dx.doi.org/10.1007/s11605-019-04230-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908777PMC
May 2020
12 Reads

[Whipple's disease: very rare, fatal without treatment but easily cured].

Lakartidningen 2019 May 28;116. Epub 2019 May 28.

Gavle sjukhus - Klinisk patologi och cytologi Gavle, Sweden Gavle sjukhus - Gastroenterologmottagning Gavle, Sweden.

Whipple's disease is a chronic infectious disease that primarily affects the small intestine, but several organs can be involved simultaneously. The disease is caused by a gram-positive bacterium called Tropheryma whipplei. The disease is difficult to suspect because it is rare, and produces unspecific and long-term symptoms. Read More

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May 2019
2 Reads

LncRNA-p21 alters the antiandrogen enzalutamide-induced prostate cancer neuroendocrine differentiation via modulating the EZH2/STAT3 signaling.

Nat Commun 2019 06 12;10(1):2571. Epub 2019 Jun 12.

George Whipple Lab for Cancer Research, Departments of Pathology, Urology, Radiation Oncology, Biology and The Wilmot Cancer Institute, University of Rochester, Rochester, NY, 14642, USA.

While the antiandrogen enzalutamide (Enz) extends the castration resistant prostate cancer (CRPC) patients' survival an extra 4.8 months, it might also result in some adverse effects via inducing the neuroendocrine differentiation (NED). Here we found that lncRNA-p21 is highly expressed in the NEPC patients derived xenograft tissues (NEPC-PDX). Read More

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http://dx.doi.org/10.1038/s41467-019-09784-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561926PMC
June 2019
8 Reads

Endoscopic entero-enteral bypass: an effective new approach to the treatment of postsurgical complications of hepaticojejunostomy.

Endoscopy 2019 12 4;51(12):1146-1150. Epub 2019 Jun 4.

Digestive and Interventional Endoscopy Unit, Niguarda-Ca' Granda Hospital, Milan, Italy.

Background: Management of biliary adverse events (BAEs) after biliodigestive anastomosis is challenging. We propose a new endoscopic approach to improve BAEs in this clinical setting.

Methods: Patients who had BAEs after a hepaticojejunostomy with Roux-en-Y loop or a Whipple procedure underwent creation of an entero-enteral endoscopic bypass (EEEB) between the duodenal/gastric wall and the biliary jejunal loop under endoscopic ultrasound (EUS) and fluoroscopic guidance using specifically designed fully covered self-expandable metal stents. Read More

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http://dx.doi.org/10.1055/a-0914-2855DOI Listing
December 2019
8 Reads

A mixed methods study of perceived barriers to physical activity, geriatric syndromes, and physical activity levels among older adults with peripheral artery disease and diabetes.

J Vasc Nurs 2019 Jun 11;37(2):91-105. Epub 2019 Mar 11.

University of Minnesota, School of Nursing, Minneapolis, MN.

Previous studies suggest a myriad of factors prevent individuals from engaging in physical activity; however, less is known about barriers faced by individuals with multiple chronic conditions, such as peripheral artery disease (PAD) and type 2 diabetes, and how these barriers may impact engagement in physical activity. To date, there are no studies that integrate simultaneous assessment of perceived barriers to physical activity and engagement in physical activity in older adults with PAD and diabetes. This integration is key to understanding the implications of barriers to physical activity and to developing strategies to address those barriers. Read More

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http://dx.doi.org/10.1016/j.jvn.2019.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556121PMC
June 2019
6 Reads

Reactive arthritis secondary to enterocolitis.

BMJ Case Rep 2019 May 28;12(5). Epub 2019 May 28.

Dipartimento di Medicina Clinica e Sperimentale, Università degli Studi di Sassari, Sassari, Italy.

Diagnosis of postenteritic reactive arthritis (ReA) is a challenge and might have a broad range of differential diagnoses. A 50-year-old man was referred to our attention because of persistent inflammatory low back pain and asymmetric oligoarthritis. The clinical history was positive for diarrhoea in the previous 3 months. Read More

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http://dx.doi.org/10.1136/bcr-2018-228513DOI Listing
May 2019
20 Reads

Whipple's disease: when diarrhea is absent.

Rev Esp Enferm Dig 2019 06;111(6):492-493

Anatomía Patológica, Hospital San Agustín.

Whipple's disease is a rare bacterial, chronic and multisystemic disease, produced by the gram-positive bacillus Tropheryma whipplei. The clinical manifestations are varied and diagnosis is often delayed. The four cardinal symptoms are arthralgias, weight loss, diarrhea and abdominal pain. Read More

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http://dx.doi.org/10.17235/reed.2019.6015/2018DOI Listing

Experience Implementing Supervised Exercise Therapy for Peripheral Artery Disease.

J Clin Exerc Physiol 2019 Mar;8(1):1-12

University of Minnesota, School of Nursing, Minneapolis, MN.

Background: Supervised exercise therapy (SET) is a cornerstone of treatment for improving walking distance for individuals with symptomatic peripheral artery disease and claudication. High quality randomized controlled trials have documented the efficacy of SET as a claudication treatment and led to the recent Centers for Medicare and Medicaid decision to cover supervised exercise therapy (SET). However, to date, the translation of highly controlled, laboratory based SET programs in real world cardiopulmonary rehabilitation settings has been unexplored. Read More

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http://dx.doi.org/10.31189/2165-6193-8.1.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529193PMC
March 2019
8 Reads