2,743 results match your criteria Whipple Disease


Early reoperation following pancreaticoduodenectomy: impact on morbidity, mortality, and long-term survival.

World J Surg Oncol 2019 Jan 31;17(1):26. Epub 2019 Jan 31.

Department of General Surgery B, Division of General Surgery, Tel-Aviv Sourasky, Medical Center, Affiliated with the Sackler Faculty of Medicine, Tel Aviv University, 6 Weizmann St., 64239, Tel-Aviv, Israel.

Background: Reoperation following PD is a surrogate marker for a complex post-operative course and may lead to devastating consequences. We evaluate the indications for early reoperation following PD and analyze its effect on short- and long-term outcome.

Methods: Four hundred and thirty-three patients that underwent PD between August 2006 and June 2016 were retrospectively analyzed. Read More

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http://dx.doi.org/10.1186/s12957-019-1569-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357503PMC
January 2019
2 Reads

Otosyphilis: Resurgence of an Old Disease.

Laryngoscope 2018 Dec 28. Epub 2018 Dec 28.

Department of Otolaryngology-Head and Neck Surgery, Harborview Medical Center, University of Washington School of Medicine, Seattle, Washington, U.S.A.

Objectives: To describe the clinical characteristics of patients presenting with a new diagnosis of otosyphilis over the past 10 years in a large, urban, safety-net hospital affiliated with a large county sexually transmitted disease clinic.

Methods: Retrospective case series. A chart review was performed of all patients who presented to an adult otolaryngology clinic with a new diagnosis of syphilis and hearing loss from January 2008 to December 2017. Read More

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http://dx.doi.org/10.1002/lary.27635DOI Listing
December 2018
2 Reads

Polypoid Undifferentiated Carcinoma With Osteoclast-like Giant Cells Arising in the Distal Common Bile Duct: A Rare Case Report.

Anticancer Res 2019 Jan;39(1):437-441

Department of Pathology, Mount Sinai Hospital, New York, NY, U.S.A.

Background: Undifferentiated carcinoma with osteoclast-like giant cells (UC-OGC) in distal common bile duct (CBD) is a rare entity.

Case Report: This case report describes a 45-year-old male with a history of a choledochal cyst status post partial excision and cholecystectomy who presented with a mass in the remaining distal/intrapancreatic common bile duct. It was initially mistaken for post-surgery hematoma; however, the rapid growth raised concern for malignancy, and prompted a pancreaticoduodenectomy (Whipple) procedure. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13131DOI Listing
January 2019
14 Reads

Minimal-invasive approach to pancreatoduodenectomy is associated with lower early postoperative morbidity.

Am J Surg 2018 Apr 19. Epub 2018 Apr 19.

Department of Surgery, University of California, San Francisco, USA; Department of Surgery, San Francisco VA Medical Center, USA. Electronic address:

Objectives: We aim to investigate the impact of the operation time for pancreatoduodenectomy (PD) in different surgical approaches.

Methods: The NSQIP database was used to examine the clinical data of patients underwent PD during 2014-2016.

Results: We sampled a total of 6151 patients who underwent elective PD. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2018.04.009DOI Listing
April 2018
13 Reads

Preoperative administration of the 5-HT4 receptor agonist prucalopride reduces intestinal inflammation and shortens postoperative ileus via cholinergic enteric neurons.

Gut 2018 Nov 24. Epub 2018 Nov 24.

Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium.

Objectives: Vagus nerve stimulation (VNS), most likely via enteric neurons, prevents postoperative ileus (POI) by reducing activation of alpha7 nicotinic receptor (α7nAChR) positive macrophages (mMφ) and dampening surgery-induced intestinal inflammation. Here, we evaluated if 5-HT4 receptor (5-HT4R) agonist prucalopride can mimic this effect in mice and human.

Design: Using Ca imaging, the effect of electrical field stimulation (EFS) and prucalopride was evaluated in situ on mMφ activation evoked by ATP in jejunal tissue. Read More

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http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2018-317263
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http://dx.doi.org/10.1136/gutjnl-2018-317263DOI Listing
November 2018
15 Reads

Ventricular global longitudinal strain is altered in children with sickle cell disease.

Br J Haematol 2018 Dec 19;183(5):796-806. Epub 2018 Nov 19.

Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA.

Cardiac disease is the primary cause of death in sickle cell disease (SCD). Right and left ventricular global longitudinal strain (RVGLS, LVGLS) are early markers of systolic dysfunction but are not well investigated among children with SCD. One hundred and forty-three patients with HbSS or HbSβ -thalassaemia (median age 11 years, range 5-19 years) and 71 controls matched for age and sex were compared. Read More

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http://doi.wiley.com/10.1111/bjh.15607
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http://dx.doi.org/10.1111/bjh.15607DOI Listing
December 2018
12 Reads

Whipple's Disease: A Well-Done Outcome to a Rare Disease.

Dig Dis Sci 2019 01;64(1):9-11

Department of Gastroenterology, Norfolk and Norwich University Hospital, Norwich, NR4 7UY, UK.

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http://dx.doi.org/10.1007/s10620-018-5342-7DOI Listing
January 2019
3 Reads

Histochemistry in the diagnosis of non-neoplastic gastrointestinal disorders.

Semin Diagn Pathol 2018 Nov 16;35(6):370-380. Epub 2018 Oct 16.

Department of Pathology, St. Jude Medical Center, Fullerton, CA 92835, United States. Electronic address:

The alimentary tract serves as host to a large number of diseases. In the non-neoplastic group of disorders, conventional histochemistry continues to play an important diagnostic role. It is particularly important in recognizing specific infectious diseases, such as Helicobacter gastritis, Whipple disease, intestinal tuberculosis and other forms of mycobacteriosis, malakoplakia, intestinal spirochetosis, fungal enteritides, amebiasis, cryptosporidiosis, isosporiasis, and microsporidiosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07402570183009
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http://dx.doi.org/10.1053/j.semdp.2018.10.002DOI Listing
November 2018
21 Reads

From Whipple Disease to Tropheryma whipplei Infection.

Authors:
Didier Raoult

Clin Infect Dis 2018 Oct 22. Epub 2018 Oct 22.

Aix Marseille Université, Institut de recherche pour le développement, Microbes Evolution Phylogenie Et Infections.

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http://dx.doi.org/10.1093/cid/ciy668DOI Listing
October 2018
3 Reads

Detection of Tropheryma whipplei in stool samples by one commercial and two in-house real-time PCR assays.

Trop Med Int Health 2019 Jan 8;24(1):101-108. Epub 2018 Nov 8.

Institute for Medical Microbiology, Virology and Hygiene, University Medicine Rostock, Rostock, Germany.

Objective: Tropheryma whipplei, the causative agent of Whipple's disease, can also be identified in stool samples of humans without systemic disease. It is much more frequently detected in human stool samples in tropical environments than in industrialized countries. PCR-screening has been applied for point prevalence studies and environmental assessments in tropical settings, but results depend on the applied assay. Read More

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http://dx.doi.org/10.1111/tmi.13172DOI Listing
January 2019
5 Reads

[F]FDG-PET for evaluating pediatric Rosai-Dorfman disease.

Pediatr Hematol Oncol 2018 Oct 22:1-4. Epub 2018 Oct 22.

e Division of Pediatric Hematology/Oncology, Department of Pediatrics , University of Mississippi Medical Center , Jackson , Mississippi , USA.

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http://dx.doi.org/10.1080/08880018.2018.1484828DOI Listing
October 2018
3 Reads

Systematic review of movement disorders and oculomotor abnormalities in Whipple's disease.

Mov Disord 2018 Nov 19;33(11):1700-1711. Epub 2018 Oct 19.

Movement Disorders Research Center, Toront Western Hospital, Toronto, Ontario, Canada.

Whipple's disease, affecting the CNS, can cause a wide variety of symptoms. Movement disorders are very prevalent, and some are pathognomonic of the disease. This systematic review analyzed all published cases of movement disorders because of CNS Whipple's disease, providing detailed information on clinical and associated features. Read More

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http://dx.doi.org/10.1002/mds.27419DOI Listing
November 2018
3 Reads

Ocular Whipple Disease: Report of Three Cases.

Ocul Immunol Inflamm 2018 Sep 7:1-4. Epub 2018 Sep 7.

c Advanced Eye Centre , Post Graduate Institute of Medical Education and Research , Chandigarh , India.

Purpose: To emphasize the different manifestations of ocular involvement in Whipple disease with challenge in establishing the diagnosis as clinical, laboratory, and histological features could mimic other uveitis entities.

Methods: Case reports of three patients.

Results: The first patient was an African male suffering from a chronic bilateral keratoconjunctitivitis that was initially misdiagnosed as a chronic allergic conjunctivitis. Read More

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http://dx.doi.org/10.1080/09273948.2018.1518461DOI Listing
September 2018
4 Reads

Bronchobiliary fistula: a rare complication after pancreaticoduodenectomy.

BMJ Case Rep 2018 Sep 4;2018. Epub 2018 Sep 4.

University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.

Biliary anatomic pathologies are rare disease occurrences that can result from a number of causes, most commonly iatrogenic, infectious and malignant aetiologies. Communications between the biliary and bronchial systems are even rarer and few cases have been documented in the literature. The present study describes a case of a 70-year-old man who underwent a pancreaticoduodenectomy (Whipple Procedure) as a curative procedure for an early stage neuroendocrine tumour. Read More

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http://dx.doi.org/10.1136/bcr-2017-221895DOI Listing
September 2018
25 Reads

Practical experience implementing supervised exercise therapy for peripheral artery disease in urban and rural Minnesota.

J Vasc Nurs 2018 09 29;36(3):157-159. Epub 2018 Jul 29.

School of Nursing, University of Minnesota, Minneapolis, Minnesota. Electronic address:

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http://dx.doi.org/10.1016/j.jvn.2018.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110094PMC
September 2018
2 Reads

Mesenteric lymphadenitis as a presenting feature of Whipple's disease: Value of PCR analysis.

Int J Infect Dis 2018 Oct 7;75:15-17. Epub 2018 Aug 7.

Department of Internal Medicine, Hôpital de la Croix Rousse, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, Lyon, France. Electronic address:

Whipple's disease (WD) is a rare chronic and systemic infection caused by the ubiquitous actinomycete Tropheryma whipplei. A case of localized infection with mesenteric adenopathy associated with a prolonged unexplained fever is reported herein. Screening by PCR on saliva and stool was positive, and T. Read More

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http://dx.doi.org/10.1016/j.ijid.2018.08.003DOI Listing
October 2018
35 Reads

Tropheryma whipplei Increases Expression of Human Leukocyte Antigen-G on Monocytes to Reduce Tumor Necrosis Factor and Promote Bacterial Replication.

Gastroenterology 2018 11 1;155(5):1553-1563. Epub 2018 Aug 1.

Aix Marseille Univ, IRD, APHM, MEPHI, IHU-Mediterranee Infection, Marseille, France. Electronic address:

Background & Aims: Infection with Tropheryma whipplei has a range of effects-some patients can be chronic carriers without developing any symptoms, whereas others can develop systemic Whipple disease, characterized by a lack a protective inflammatory immune response. Alterations in HLA-G function have been associated with several diseases. We investigated the role of HLA-G during T whipplei infection. Read More

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http://dx.doi.org/10.1053/j.gastro.2018.07.034DOI Listing
November 2018
7 Reads

Usefulness of polymerase chain reaction for diagnosing Whipple's disease in rheumatology.

PLoS One 2018 18;13(7):e0200645. Epub 2018 Jul 18.

Rheumatology Unit, Hôpital de la Cavale Blanche, Brest, France.

Objectives: To determine when Tropheryma whipplei polymerase chain reaction (PCR) is appropriate in patients evaluated for rheumatological symptoms.

Methods: In a retrospective observational study done in rheumatology units of five hospitals, we assessed the clinical and radiological signs that prompted T. whipplei PCR testing between 2010 and 2014, the proportion of patients diagnosed with Whipple's disease, the number of tests performed and the number of diagnoses according to the number of tests, the patterns of Whipple's disease, and the treatments used. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200645PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051605PMC
January 2019
8 Reads

Identification of putative drug targets and annotation of unknown proteins in Tropheryma whipplei.

Comput Biol Chem 2018 Oct 9;76:130-138. Epub 2018 Jun 9.

Molecular and Cellular Engineering Group, BioQuant, University of Heidelberg, Heidelberg, Germany; The Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology (HBIGS), University of Heidelberg, Heidelberg, Germany. Electronic address:

Tropheryma whipplei (T. whipplei) is the causative agent of Whipple's disease and blood culture-negative endocarditis. Due to the variability of symptoms, the disease is often poorly diagnosed. Read More

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http://dx.doi.org/10.1016/j.compbiolchem.2018.05.024DOI Listing
October 2018
21 Reads
1.120 Impact Factor

Diagnostic Approach for Classic Compared With Localized Whipple Disease.

Open Forum Infect Dis 2018 Jul 13;5(7):ofy136. Epub 2018 Jun 13.

Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota.

Background: Whipple disease (WD), a rare systemic infection caused by can be a diagnostic challenge due to its variable presentation. The role of polymerase chain reaction (PCR) is unclear as small bowel biopsy with Periodic acid-Schiff (PAS) staining remains the diagnostic gold standard. Individualized diagnostic approaches based on variable clinical manifestations are underutilized. Read More

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http://dx.doi.org/10.1093/ofid/ofy136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030902PMC
July 2018
3 Reads

Venting post-Whipple benign gastric outlet obstruction with temporary bilateral fully covered metal stents.

VideoGIE 2017 Dec 29;2(12):349-352. Epub 2017 Sep 29.

Digestive Disease Institute, Virginia Mason Medical Center, Seattle, Washington, USA.

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http://dx.doi.org/10.1016/j.vgie.2017.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003889PMC
December 2017
10 Reads

A Case of Whipple's Disease: A Very Rare Cause for Rapidly Progressive Dementia.

Indian J Psychol Med 2018 May-Jun;40(3):280-283

Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

Introduction: Whipple's disease (WD) is a very rare systemic disease caused by the gram-positive bacillus Tropherymawhippleii 1st described in the year 1907. It is a disease with multisystem involvement and high degree of suspicion is needed for diagnosis. However the classical (OMM)oculomasticatory (OFMM)oculofacial-skeletal myorhythmia clubbed with dementia, head ache and other neurologic features should deserve an attempt to confirm whenever possible and therapeutic trial as it is one of the treatable dementias. Read More

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http://dx.doi.org/10.4103/IJPSYM.IJPSYM_149_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968653PMC
June 2018
11 Reads

Isolierter zerebraler Morbus Whipple.

Rofo 2018 Nov 6;190(11):1059-1061. Epub 2018 Jun 6.

Institute of Radiology, University Hospital St. Pölten, Austria.

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http://dx.doi.org/10.1055/a-0581-5421DOI Listing
November 2018
2 Reads

Estrogen receptor β promotes renal cell carcinoma progression via regulating LncRNA HOTAIR-miR-138/200c/204/217 associated CeRNA network.

Oncogene 2018 09 23;37(37):5037-5053. Epub 2018 May 23.

Departments of Urology and Pathology, George Whipple Lab for Cancer Research, University of Rochester Medical Center, Rochester, NY, 14642, USA.

Recent studies indicated that the estrogen receptor beta (ERβ) could affect the progression of prostate and bladder tumors, however, its roles in the renal cell carcinoma (RCC), remain to be elucidated. Here, we provide clinical evidence that ERβ expression is correlated in a negative manner with the overall survival/disease-free survival in RCC patients. Mechanism dissection revealed that targeting ERβ with ERβ-shRNA and stimulating the transactivation of ERβ with 17β-estradiol or environmental endocrine disrupting chemicals, all resulted in altering the lncRNA HOTAIR expression. Read More

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http://dx.doi.org/10.1038/s41388-018-0175-6DOI Listing
September 2018
20 Reads

A comprehensive review and meta-analysis of risk factors for statin-induced myopathy.

Eur J Clin Pharmacol 2018 Sep 22;74(9):1099-1109. Epub 2018 May 22.

Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

Purpose: To aid prescribers in assessing a patient's risk for statin-induced myopathy (SIM), we performed a comprehensive review of currently known risk factors and calculated aggregated odds ratios for each risk factor through a meta-analysis.

Methods: This meta-analysis was done through four phases: (1) Identification of the relevant primary literature; (2) abstract screening using inclusion and exclusion criteria; (3) detailed review and data extraction; and (4) synthesis and statistical analysis.

Results: Out of 44 papers analyzed from 836 papers searched from MEDLINE, 18 different potential risk factors were collected, divided into three categories: three demographics (11 papers), ten clinical factors (31 papers), and five pharmacogenetics/biomarkers (12 papers). Read More

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http://dx.doi.org/10.1007/s00228-018-2482-9DOI Listing
September 2018
4 Reads

Atypical response of spondyloarthritis to biologics revealing Whipple's disease: A case-report.

Therapie 2018 Oct 3;73(5):437-439. Epub 2018 Mar 3.

Service de rhumatologie, CHRU de Nancy, bâtiment des spécialités médicales, site de Brabois, 545011 Vandœuvre lès Nancy, France.

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http://dx.doi.org/10.1016/j.therap.2018.02.008DOI Listing
October 2018
26 Reads

IgLON5-mediated neurodegeneration is a differential diagnosis of CNS Whipple disease.

Neurology 2018 Jun 16;90(24):1113-1115. Epub 2018 May 16.

From the Movement Disorders Unit, Neurology Department (H.M.-B., B.C., A.F.F., V.F.), Department of Immunology (M.-W.L., J.J.), and Department of Tissue Pathology and Diagnostic Oncology, ICPMR (W.V.), Westmead Hospital; Woolcock Institute of Medical Research (D.B., R.G.), Sydney Medical School (H.M.-B., A.F.F., V.F.), the University of Sydney; Douglass Hanly Moir Pathology (M.R.), New South Wales; and Neuroscience Research Australia (C.S.), Sydney, Australia.

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http://dx.doi.org/10.1212/WNL.0000000000005679DOI Listing
June 2018
3 Reads

EUS-guided hepaticoenterostomy as a portal to allow definitive antegrade treatment of benign biliary diseases in patients with surgically altered anatomy.

Gastrointest Endosc 2018 Sep 3;88(3):547-554. Epub 2018 May 3.

Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC, USA.

Background And Aims: EUS-guided hepaticoenterostomy (EUS-HE) usually is reserved for palliation of malignant biliary obstruction after failed endoscopic retrograde cholangiography (ERC) or inaccessible biliary tree in surgically altered anatomy (SAA). We describe the outcome of EUS-HE and antegrade therapy for benign biliary disease in patients with SAA.

Methods: Retrospective review of 20 consecutive patients with surgically altered anatomy and benign biliary obstruction who underwent EUS-HE performed by 1 endoscopist at a tertiary-care center over a 3-year period. Read More

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http://dx.doi.org/10.1016/j.gie.2018.04.2353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097896PMC
September 2018
21 Reads

[Movement disorders in a 32-year-old woman].

Rev Med Interne 2018 Jul 1;39(7):597-599. Epub 2018 May 1.

Service de médecine interne, hôpital Cochin, 27, rue du Faubourg-Saint-Jacques 75014 Paris, France.

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http://dx.doi.org/10.1016/j.revmed.2018.04.007DOI Listing
July 2018
6 Reads

Gamma delta T cell expansion in Whipple's disease with muscular granulomatous vasculitis.

Infection 2018 Aug 3;46(4):573-576. Epub 2018 May 3.

Department of Internal Medicine and Infectious Diseases, CHU Bordeaux, Hôpital Haut Lévèque, 33600, Pessac, France.

Whipple's disease usually presents as chronic joint pain followed by digestive manifestations. However, many different presentations have been described in the literature. We report here the first proven case of muscular vasculitis related to Whipple's disease, associated with an expansion of circulating activated γδ T lymphocytes. Read More

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http://dx.doi.org/10.1007/s15010-018-1143-3DOI Listing
August 2018
1 Read

Whipple Disease Presenting as Cystic Brain Tumor: Case Report and Review of the Literature.

Turk Neurosurg 2018 ;28(3):495-499

Fattouma Bourguiba University Hospital, Department of Neurosurgery, Monastir, Tunisia.

Although neurological features are commonly encountered in Whipple"s disease (WD), presentation with purely neurological patterns is uncommon. Exclusive confinement to the central nervous system (CNS) is extremely rare. In these cases, the development of an isolated cerebral mass is exceptional. Read More

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http://dx.doi.org/10.5137/1019-5149.JTN.17111-16.2DOI Listing
August 2018
4 Reads

Cutaneous Metastasis of Adenocarcinoma of the Ampulla of Vater.

Am J Dermatopathol 2018 Oct;40(10):758-761

Department of Dermatology, Los Angeles Medical Center (LAMC), Southern California Kaiser Permanente, Los Angeles, CA.

Cutaneous metastases from an adenocarcinoma of the Ampulla of Vater are very rare, with only a few cases previously reported. We present here an additional case in a 57-year-old woman who complained of a painful growth on her frontal scalp that she had noticed 4 months earlier. Her medical history included an ampullary adenocarcinoma, which was diagnosed 4 years ago, excised through a Whipple procedure, and treated using chemotherapy and radiotherapy. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001155DOI Listing
October 2018
1 Read

Chronic Pancreatitis: Diagnosis and Treatment.

Authors:
Kathleen Barry

Am Fam Physician 2018 Mar;97(6):385-393

University of Texas Health Science Center at Houston, Houston, TX, USA.

Chronic pancreatitis is an irreversible and progressive disorder of the pancreas characterized by inflammation, fibrosis, and scarring. Exocrine and endocrine functions are lost, often leading to chronic pain. The etiology is multifactorial, although alcoholism is the most significant risk factor in adults. Read More

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March 2018
11 Reads

Back from the brink of obscurity.

Authors:
Donald C Vinh

Elife 2018 04 18;7. Epub 2018 Apr 18.

Department of Medicine, McGill University Health Centre, Montreal, Canada.

A mutation in a transcription factor makes people susceptible to , the bacterium that causes a rare condition called Whipple's disease. Read More

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http://dx.doi.org/10.7554/eLife.36649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906093PMC
April 2018
38 Reads

CNS Langerhans cell histiocytosis: Common hematopoietic origin for LCH-associated neurodegeneration and mass lesions.

Cancer 2018 Jun 6;124(12):2607-2620. Epub 2018 Apr 6.

Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.

Background: Central nervous system Langerhans cell histiocytosis (CNS-LCH) brain involvement may include mass lesions and/or a neurodegenerative disease (LCH-ND) of unknown etiology. The goal of this study was to define the mechanisms of pathogenesis that drive CNS-LCH.

Methods: Cerebrospinal fluid (CSF) biomarkers including CSF proteins and extracellular BRAFV600E DNA were analyzed in CSF from patients with CNS-LCH lesions compared with patients with brain tumors and other neurodegenerative conditions. Read More

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http://dx.doi.org/10.1002/cncr.31348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289302PMC
June 2018
17 Reads
4.890 Impact Factor

Synchronous Pancreatic Serous Cystic Neoplasm and Duodenal Neuroendocrine Tumor: Case Report and Review of the Literature.

Int J Surg Pathol 2018 Sep 6;26(6):551-557. Epub 2018 Apr 6.

1 Department of Pathology, Odense University Hospital, Odense, Denmark.

Simultaneous presence of pancreatic serous cystic neoplasms and neuroendocrine neoplasms is rare. We present a case with the incidental finding of a duodenal neuroendocrine tumor (NET) with 2 lymph node metastases in a Whipple resection specimen performed to remove a pancreatic cystic neoplasm that postoperatively turned out to represent a serous cystic neoplasm (SCN). The patient was a 75-year-old female. Read More

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http://journals.sagepub.com/doi/10.1177/1066896918766245
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http://dx.doi.org/10.1177/1066896918766245DOI Listing
September 2018
9 Reads

[Multidisciplinary approach to surgical disorders of the pancreas in children].

Rozhl Chir 2018 ;97(3):109-116

Introduction: Surgical diseases of the pancreas in children are not common and may be associated with significant morbidity and potential mortality. A multidisciplinary approach is essential for correct diagnosis, surgical strategy and postoperative as well as follow-up care.

Method: Retrospective analysis of patients operated on due to a pathological lesion of the pancreas focused on diagnostics, operating procedures, postoperative complications, and long-term results. Read More

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January 2018
25 Reads

Tropheryma whipplei Infection (Whipple Disease) in the USA.

Dig Dis Sci 2019 01 23;64(1):213-223. Epub 2018 Mar 23.

Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street, S.W., Rochester, MN, 55905, USA.

Background: Whipple disease (WD) is an infection caused by the bacterium Tropheryma whipplei (TW). Few cases have been reported in the USA.

Aims: To report on the demographics, clinical manifestations, diagnostic findings, treatment, and outcomes of TW infection. Read More

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http://dx.doi.org/10.1007/s10620-018-5033-4DOI Listing
January 2019
26 Reads

Whipple's disease: a rare case of malabsorption.

BMJ Case Rep 2018 Mar 5;2018. Epub 2018 Mar 5.

Department of Medicina Interna, Hospital Egas Moniz, Lisbon, Portugal.

Whipple's disease is a chronic, rare, multisystemic, infectious entity, described for the first time in 1907. Its aetiological agent is the Gram-negative rod, which was isolated for the first time in 2001 from a cardiac valve of a patient with endocarditis. We present the case of a 71-year-old man, who came into the emergency room complaining of anorexia, weakness, abdominal pain and diarrhoea with haematochezia and presented disseminated palpable purpuric lesions, predominantly in the lower limbs. Read More

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http://dx.doi.org/10.1136/bcr-2017-222955DOI Listing
March 2018
6 Reads

ERβ-Mediated Alteration of circATP2B1 and miR-204-3p Signaling Promotes Invasion of Clear Cell Renal Cell Carcinoma.

Cancer Res 2018 May 28;78(10):2550-2563. Epub 2018 Feb 28.

George Whipple Lab for Cancer Research, Departments of Urology, Pathology, Radiation Oncology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York.

Early studies have indicated that estrogen receptor beta (ERβ) can influence the progression of clear cell renal cell carcinoma (ccRCC). Here, we report the mechanistic details of ERβ-mediated progression of ccRCC. ERβ increased ccRCC cell invasion via suppression of circular RNA ATP2B1 (circATP2B1) expression by binding directly to the 5' promoter region of its host gene ATPase plasma membrane Ca2 transporting 1 (ATP2B1). Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-17-1575DOI Listing
May 2018
9 Reads

Pancreaticoduodenectomy in the surgical management of primary retroperitoneal sarcoma.

Eur J Surg Oncol 2018 06 5;44(6):810-815. Epub 2018 Feb 5.

Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Background: In retroperitoneal sarcoma (RPS), the optimal extent of resection must balance adequate disease control with potential for morbidity. We sought to study the frequency and outcomes after a Whipple procedure or pancreaticoduodenectomy (PD) in patients undergoing resection for primary RPS.

Methods: Participating referral centers within the Trans-Atlantic Retroperitoneal Sarcoma Working Group provided retrospective data from January 2007 to December 2016 for patients with primary RPS who underwent PD along with the total number of consecutive resections done during the same time period. Read More

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http://dx.doi.org/10.1016/j.ejso.2018.01.086DOI Listing
June 2018
10 Reads

Translation of an evidence-based therapeutic exercise program for patients with peripheral artery disease.

J Vasc Nurs 2018 03 1;36(1):23-33. Epub 2017 Nov 1.

School of Nursing, University of Minnesota, Minneapolis, MN.

The purpose of this study was to implement and evaluate quality outcomes including referral, enrollment, and completion rates of a new peripheral artery disease (PAD)-specific supervised exercise therapy (SET) program within a preexisting clinical exercise wellness program and to evaluate the clinical effectiveness and patient-centered outcomes derived from 12 weeks of PAD-specific SET. Recruited participants completed an individualized, minimally supervised, PAD-specific SET program based on the AHA-ACC guidelines. Exercise workloads (metabolic equivalents of task [METs]) were tracked and evaluated throughout the program. Read More

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http://dx.doi.org/10.1016/j.jvn.2017.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862037PMC
March 2018
7 Reads

Whipple's Disease with Long-term Endoscopic Follow-up.

Intern Med 2018 Jun 9;57(12):1707-1713. Epub 2018 Feb 9.

Department of Internal Medicine, Okayama Saiseikai General Hospital, Japan.

A 72-year-old man presented with anorexia and 15-kg weight loss over 3 years. Endoscopy revealed yellow, shaggy mucosa alternating with erythematous, eroded mucosa in the duodenum. Biopsy specimens showed massive infiltration of periodic acid-Schiff-positive macrophages in the lamina propria, consistent with Whipple's disease. Read More

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http://dx.doi.org/10.2169/internalmedicine.9631-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047986PMC
June 2018
22 Reads

Whipple's disease mimicking an auto-inflammatory disease with myositis and soft tissue inflammation.

Joint Bone Spine 2018 Oct 31;85(5):645-646. Epub 2018 Jan 31.

Department of Rheumatology, University Hospital Basel, Basel, Switzerland.

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http://dx.doi.org/10.1016/j.jbspin.2018.01.003DOI Listing
October 2018
7 Reads

Minimally invasive versus open pancreatoduodenectomy (LEOPARD-2): study protocol for a randomized controlled trial.

Trials 2018 Jan 3;19(1). Epub 2018 Jan 3.

Department of Surgery, Academic Medical Center, Cancer Center Amsterdam, PO Box 22660, 1100 DD, Amsterdam, The Netherlands.

Background: Data from observational studies suggest that minimally invasive pancreatoduodenectomy (MIPD) is superior to open pancreatoduodenectomy regarding intraoperative blood loss, postoperative morbidity, and length of hospital stay, without increasing total costs. However, several case-matched studies failed to demonstrate superiority of MIPD, and large registry studies from the USA even suggested increased mortality for MIPDs performed in low-volume (<10 MIPDs annually) centers. Randomized controlled multicenter trials are lacking but clearly required. Read More

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https://trialsjournal.biomedcentral.com/articles/10.1186/s13
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http://dx.doi.org/10.1186/s13063-017-2423-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753506PMC
January 2018
54 Reads

Neurological and neuropsychological complications in the course of chronic Whipple's disease - case report.

Psychiatr Pol 2017 Oct 29;51(5):953-961. Epub 2017 Oct 29.

Katedra i Klinika Neurologii, Wydział Lekarski ŚUM w Katowicach.

Introduction: Whipple's disease (WD) is a chronic, multisystemic infectious disease caused by Gram-positive bacillus Tropheryma whipplei (T.w.). Read More

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http://dx.doi.org/10.12740/PP/OnlineFirst/61131DOI Listing
October 2017
20 Reads

Periampullary Carcinoma: Unusual Sites of Metastasis.

Ochsner J 2017 ;17(4):426-429

National Institute of Pathology, Indian Council of Medical Research, Safdarjung Hospital, New Delhi, India.

Background: Periampullary neoplasms include carcinomas of the duodenum, ampulla of Vater, distal common bile duct, and pancreas. The aggressive course of these neoplasms is attributable to the delay in diagnosis, as patients have no symptoms until advanced stages of the disease. More than half of patients have distant metastasis at the time of diagnosis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718458PMC
January 2017
23 Reads

Postoperative endophthalmitis - a case report highlighting the additive value of molecular testing.

JMM Case Rep 2017 Oct 23;4(10):e005124. Epub 2017 Oct 23.

University of Würzburg, Institute for Hygiene and Microbiology, Josef-Schneider-Str. 2 E1, 97080 Wuerzburg, Germany.

is the causative agent of Whipple's disease. Gastrointestinal and lymphatic tissues are affected in the majority of cases, resulting in diarrhoea, malabsorption and fever. Here, we report a rare case of ocular manifestation in a patient lacking the typical Whipple symptoms. Read More

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http://dx.doi.org/10.1099/jmmcr.0.005124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692240PMC
October 2017
9 Reads

Unraveling Diagnostic Uncertainty Surrounding Lyme Disease in Children with Neuropsychiatric Illness.

Child Adolesc Psychiatr Clin N Am 2018 Jan 21;27(1):27-36. Epub 2017 Oct 21.

Division of Pediatric Emergency Medicine, Alpert Medical School of Brown University, Rhode Island Hospital - Hasbro Children's Hospital, 125 Whipple Street, UEMF Suite-3rd Floor, Providence, RI 02908, USA.

Lyme disease is endemic in parts of the United States, including New England, the Atlantic seaboard, and Great Lakes region. The presentation has various manifestations, many of which can mimic psychiatric diseases in children. Distinguishing manifestations of Lyme disease from those of psychiatric illnesses is complicated by inexact diagnostic tests and misuse of these tests when they are not clinically indicated. Read More

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http://dx.doi.org/10.1016/j.chc.2017.08.010DOI Listing
January 2018
22 Reads