2,898 results match your criteria Whipple Disease


Intraperitoneal gemcitabine chemotherapy is safe for patients with resected pancreatic cancer: final clinical and pharmacologic data from a phase II protocol and recommended future directions.

J Gastrointest Oncol 2021 Apr;12(Suppl 1):S99-S109

Center for Gastrointestinal Malignancies, MedStar Washington Hospital Center, Washington, DC, USA.

Worldwide, the surgical management of pancreas cancer using the Whipple procedure results in long-term survival in approximately 20% of patients when there is a R0 resection. Local recurrence within the resection site and peritoneal metastases are a prominent part of this treatment failure. Gemcitabine was used for a regional chemotherapy treatment strategy. Read More

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A Framework for Outpatient Infusion of Antispike Monoclonal Antibodies to High-Risk Patients with Mild-to-Moderate Coronavirus Disease-19: The Mayo Clinic Model.

Mayo Clin Proc 2021 05 9;96(5):1250-1261. Epub 2021 Mar 9.

Division of Pediatric Infectious Diseases, Mayo Clinic, Rochester, MN.

The administration of spike monoclonal antibody treatment to patients with mild to moderate COVID-19 is very challenging. This article summarizes essential components and processes in establishing an effective spike monoclonal antibody infusion program. Rapid identification of a dedicated physical infrastructure was essential to circumvent the logistical challenges of caring for infectious patients while maintaining compliance with regulations and ensuring the safety of our personnel and other patients. Read More

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The Landscape of Cell-free HBV Integrations and Mutations in Cirrhosis and Hepatocellular Carcinoma Patients.

Clin Cancer Res 2021 May 4. Epub 2021 May 4.

Berry Oncology Corporation, Beijing, China.

Purpose: Intratumoral hepatitis B virus (HBV) integrations and mutations are related to hepatocellular carcinoma (HCC) progression. Circulating cell-free DNA (cfDNA) has shown itself as a powerful non-invasive biomarker for cancer. However, the HBV integration and mutation landscape on cfDNA remains unclear. Read More

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Signet ring cell cancer of Ampulla of Vater-first ever case reported in a teenager and a review of literature.

Rare Tumors 2021 12;13:20363613211007767. Epub 2021 Apr 12.

Cancer Foundation Hospital, Karachi, Pakistan.

Ampullary cancers are rare accounting for 0.2% of all gastrointestinal cancers. Signet ring is a rare variant of adenocarcinoma, characterized by having more than 50% of mucin secreting cells and clinically having a worse prognosis. Read More

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The Path of Most Resistance: A Rare Instance of Metastatic Pancreatic Adenocarcinoma Identified Within Skeletal Muscle.

Cureus 2021 Mar 17;13(3):e13947. Epub 2021 Mar 17.

Radiology, University of Florida College of Medicine, Jacksonville, USA.

Soft tissue neoplastic metastases, specifically to the skeletal muscle, are uncommon in comparison to metastases within the abdomen, thorax, or intracranial regions. Specifically, pancreatic adenocarcinoma with skeletal muscle metastasis is a rare clinical phenomenon and is hardly reported. There is a high mortality rate after the diagnosis of metastatic pancreatic adenocarcinoma, attributed to inadequate screening and advanced staging upon incidental discovery. Read More

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Hepatobiliary Manifestations of Whipple Disease.

Clin Liver Dis (Hoboken) 2021 Mar 13;17(3):180-183. Epub 2021 Apr 13.

Division of Gastroenterology and Hepatology Department of Medicine Miller School of Medicine University of Miami Miami FL.

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Real robotic total mesopancreas excision (TMpE) assisted by hanging manoeuver (HM): Standardised technique.

Int J Med Robot 2021 Apr 7. Epub 2021 Apr 7.

Department of General and Minimally Invasive Surgery (Laparoscopy and Robotic), Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg.

Background: Pancreaticoduodenectomy (PD) is one of the most demanding interventions for digestive surgeons. R0 resection is a key point for the overall survival and disease-free survival. Total mesopancreas excision (TMpE) has been described by laparotomy but laparoscopy did not provide good results probably because of the technical difficulties of the approach. Read More

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Persistence of Facio-Skeletal Myorhythmia During Sleep in anti-IgLON5 Disease.

Mov Disord Clin Pract 2021 Apr 25;8(3):460-463. Epub 2021 Feb 25.

IRCCS Istituto delle Scienze Neurologiche di Bologna UOC Clinica Neurologica Rete Metropolitana NEUROMET Bologna Italy.

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The Effect of Tocilizumab on Inflammatory Markers in Patients Hospitalized with Serious Infections. Case Series and Review of Literature.

Life (Basel) 2021 Mar 20;11(3). Epub 2021 Mar 20.

Department of Rheumatology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

Background: The human anti-IL-6 receptor antibody tocilizumab (TCZ) has been approved for the treatment of rheumatoid arthritis (RA) and giant cell arteritis (GCA). It is observed that CRP levels drop quickly after starting TCZ treatment. This may lead to misinterpretation of laboratory results when accessing the patient with infectious disease while on TCZ. Read More

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Ethical considerations for research involving pregnant women living with HIV and their young children: a systematic review of the empiric literature and discussion.

BMC Med Ethics 2021 Apr 1;22(1):38. Epub 2021 Apr 1.

Department of Pediatrics, The Ryan White Center for Pediatric Infectious Disease and Global Health, Indiana University School of Medicine, 705 Riley Hospital Drive, Room 5853, Indianapolis, IN, 46202, USA.

Background: The proper and ethical inclusion of PWLHIV and their young children in research is paramount to ensure valid evidence is generated to optimize treatment and care. Little empirical data exists to inform ethical considerations deemed most critical to these populations. Our study aimed to systematically review the empiric literature regarding ethical considerations for research participation of PWLHIV and their young children. Read More

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Hepatolithiasis: clinical series, review and current management strategy.

Turk J Surg 2020 Dec 29;36(4):382-392. Epub 2020 Dec 29.

Department of Pathology, İzmir Katip Çelebi University School of Medicine, İzmir, Turkey.

Objectives: Hepatolithiasis (HL) continues to be a problem due to its local and systemic complications, insufficiency in treatment modalities and high risk of recurrence. There are various surgical options available, ranging from endoscopic interventions to a small segment resection and ultimately to transplantation. In this article, patients with the diagnosis of HL and our treatment strategies were evaluated in the light of literature. Read More

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December 2020

Whipple's disease: the great masquerader-a high level of suspicion is the key to diagnosis.

BMC Gastroenterol 2021 Mar 20;21(1):128. Epub 2021 Mar 20.

Department of Medicine, Karolinska Institutet, Solna, Sweden.

Background: Whipple's disease is a chronic infectious disease that primarily affects the small intestine, but several organs can simultaneously be involved. The disease is caused by a gram-positive bacterium called Tropheryma whipplei. The disease is difficult to suspect because it is rare with unspecific and long-term symptoms; it can be lethal if not properly treated. Read More

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Sickle cell disease and ventricular myocardial strain: A systematic review.

Pediatr Blood Cancer 2021 Jun 19;68(6):e28973. Epub 2021 Mar 19.

Department of Hematology, St Jude Children's Research Hospital, Memphis, Tennessee, USA.

Cardiac disease is the primary cause of death in sickle cell disease (SCD). Cardiac abnormalities begin in childhood and progress throughout life. Right and left ventricular (RV, LV) myocardial strain are early markers of systolic dysfunction but are not well investigated among individuals with SCD. Read More

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Tropheryma whipplei endocarditis.

Echocardiography 2021 Apr 12;38(4):697-700. Epub 2021 Mar 12.

Wessex Cardiothoracic Centre, Southampton General Hospital, Southampton, UK.

Tropheryma whipplei is a bacterium that causes a rare infection called Whipple's disease and can cause devastating effects if left untreated. It is important to recognize that patients with this infection may present with atypical symptoms and are often apyrexial with normal inflammatory markers. Moreover, routine blood cultures often do not isolate these bacteria in conventional growth media. Read More

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Tropheryma whipplei in Feces of Patients with Diarrhea in 3 Locations on Different Continents.

Emerg Infect Dis 2021 Mar;27(3):932-935

We examined fecal specimens of patients with diarrhea from 3 continents for Tropheryma whipplei and enteropathogens. T. whipplei was most common in South Africa, followed by Singapore and Germany. Read More

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[Whipple's disease and reversible pulmonary hypertension].

Medicina (B Aires) 2021 ;81(1):91-95

Servicio de Anatomía Patológica, Hospital Británico de Buenos Aires, Argentina.

Whipple's disease is a chronic mutisystem disease caused by the bacteria Tropherima whipplei. Approximately 1200 cases have been described in the literature. The worldwide incidence is estimated at 9. Read More

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February 2021

A Case of Whipple Disease With Cutaneous Manifestations.

Am J Dermatopathol 2021 Feb 16. Epub 2021 Feb 16.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada; Division of Anatomical Pathology, Department of Pathology and Laboratory Medicine, Dalhousie University, Halifax, Canada; Department of Pathology, Nova Scotia Health Authority (Central Zone), Halifax, Canada; Department of Medicine, Dalhousie University, Halifax, Canada; and Division of Rheumatology, Department of Medicine, Nova Scotia Health Authority (Central Zone) and Dalhousie University, Halifax, Canada.

Abstract: Whipple disease (WD) is a rare bacterial infectious disease that is classically characterized by years of arthralgia, followed by malabsorption, diarrhea, and weight loss. However, WD may manifest in virtually any organ system, and patients with WD rarely develop subcutaneous erythema nodosum-like lesions. We report a case of a 51-year-old man diagnosed with WD who subsequently developed widely distributed erythematous subcutaneous nodules after 5 months of antibiotic therapy. Read More

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February 2021

Radiation segmentectomy of hepatic metastases with Y-90 glass microspheres.

Abdom Radiol (NY) 2021 Feb 19. Epub 2021 Feb 19.

Interventional Radiology Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.

Purpose: To evaluate safety and efficacy of radiation segmentectomy (RS) with Y glass microspheres in patients with limited metastatic liver disease not amenable to resection or percutaneous ablation.

Methods: Patients with ≤ 3 tumors treated with RS from 6/2015 to 12/2017 were included. Target tumor radiation dose was > 190 Gy based on medical internal radiation dose (MIRD) dosimetry. Read More

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February 2021

Reliable, scalable functional genetics in bloodstream-form Trypanosoma congolense in vitro and in vivo.

PLoS Pathog 2021 01 22;17(1):e1009224. Epub 2021 Jan 22.

School of Life Sciences, University of Nottingham, Nottingham, United Kingdom.

Animal African trypanosomiasis (AAT) is a severe, wasting disease of domestic livestock and diverse wildlife species. The disease in cattle kills millions of animals each year and inflicts a major economic cost on agriculture in sub-Saharan Africa. Cattle AAT is caused predominantly by the protozoan parasites Trypanosoma congolense and T. Read More

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January 2021

Ectopic liver tissue (choristoma) on the gallbladder: A comprehensive literature review.

World J Gastrointest Surg 2020 Dec;12(12):534-548

Department of Liver Transplant Institute, Inonu University, Malatya 44280, Turkey.

Background: Liver tissue situated outside the liver with a hepatic connection is usually called an accessory liver, and that without a connection to the mother liver, is called ectopic liver tissue.

Aim: To identify studies in the literature on ectopic liver tissue located on the gallbladder surface or mesentery.

Methods: We present two patients and review published articles on ectopic liver tissue located on the gallbladder surface accessed PubMed, MEDLINE, Google Scholar, and Google databases. Read More

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December 2020

Partial pancreatic tail preserving subtotal pancreatectomy for pancreatic cancer: Improving glycemic control and quality of life without compromising oncological outcomes.

World J Gastrointest Surg 2020 Dec;12(12):491-506

Department of Pancreatic Surgery, Pancreatic Disease Institute, Huashan Hospital, Shanghai 200040, China.

Background: Total pancreatectomy (TP) is usually considered a therapeutic option for pancreatic cancer in which Whipple surgery and distal pancreatectomy are undesirable, but brittle diabetes and poor quality of life (QoL) remain major concerns. A subset of patients who underwent TP even died due to severe hypoglycemia. For pancreatic cancer involving the pancreatic head and proximal body but without invasion to the pancreatic tail, we performed partial pancreatic tail preserving subtotal pancreatectomy (PPTP-SP) in selected patients, in order to improve postoperative glycemic control and QoL without compromising oncological outcomes. Read More

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December 2020

Endoscopic and percutaneous biliary interventions in patients with altered upper gastrointestinal anatomy-the Munich Multicenter Experience.

Surg Endosc 2021 Jan 4. Epub 2021 Jan 4.

Medizinische Klinik II, Krankenhaus Landshut-Achdorf, Akademisches Lehrkrankenhaus der TU München, Achdorferweg 3, 84036, Landshut, Germany.

Background: In patients with altered upper gastrointestinal anatomy, conventional endoscopic retrograde cholangiography is often not possible and different techniques, like enteroscopy-assisted or percutaneous approaches are required. Aim of this study was to analyze success and complication rates of these techniques in a large collective of patients in the daily clinical practice in a pre-endosonographic biliary drainage era.

Patients And Methods: Patients with altered upper gastrointestinal anatomy with biliary interventions between March 1st, 2006, and June 30th, 2014 in four tertiary endoscopic centers in Munich, Germany were retrospectively analyzed. Read More

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January 2021

Confirmed Hypoglycemia Without Whipple Triad: A Rare Case of Hyper-Warburgism.

J Endocr Soc 2021 Jan 21;5(1):bvaa182. Epub 2020 Nov 21.

Division of Endocrinology, Department of Internal Medicine, University at Buffalo and Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.

Spontaneous hypoglycemia in nondiabetic patients poses a diagnostic challenge. Hypoglycemia in malignancy has several etiologies; an extremely rare mechanism is the Warburg effect causing excess lactate production and avid glucose consumption. We describe the clinical course of a 52-year-old man admitted for chest wall mass and severe but asymptomatic hypoglycemia. Read More

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January 2021

Individual Differences in Response to Supervised Exercise Therapy for Peripheral Artery Disease.

West J Nurs Res 2020 Dec 17:193945920977479. Epub 2020 Dec 17.

School of Nursing, University of Minnesota - Twin Cities, Minneapolis, MN, USA.

Nonresponse to exercise has been extensively examined in young athletes but is seldom reported in studies of aerobic exercise interventions in older adults. This study examined the prevalence of nonresponse and poor response to exercise in functional and quality of life outcomes and response patterns between and among older adults undergoing 12-weeks of supervised exercise therapy for the management of peripheral artery disease ( = 44, mean age 72.3 years, 47. Read More

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December 2020

Mesenteric panniculitis as a presentation of Whipple's disease: case report and review of the literature.

Acta Gastroenterol Belg 2020 Oct-Dec;83(4):666-668

Department of Pathology, University Hospitals Leuven, Belgium.

Background: Whipple's disease is a rare, multi-organ disease caused by Tropheryma Whipplei. A classic presentation is characterized by arthropathy, diarrhea and weight loss but a broad spectrum of manifestations is possible. We present a case of a patient with mesenteric panniculitis as a manifestation of WD. Read More

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December 2020

Emergency Pancreatoduodenectomy for Ampullary Cancer Post-Iatrogenic Duodenal Perforation: No Option but to Strike.

Cureus 2020 Nov 8;12(11):e11384. Epub 2020 Nov 8.

Pathology, All India Institute of Medical Sciences, Jodhpur, Jodhpur, IND.

Endoscopic retrograde cholangiography related duodenal perforation is an infrequent complication and associated with significant morbidity. The management of such perforations, especially in the setting of malignancy, is not standardized given the paucity of literature. We encountered a patient who was diagnosed with periampullary carcinoma and had a perforation in the duodenum during endoscopy. Read More

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November 2020

[A 3-week history of intestinal symptoms in a 67-year-old male patient with chronic arthralgia].

Internist (Berl) 2021 Apr 9;62(4):433-440. Epub 2020 Dec 9.

Medizinische Klinik 1, ViDia Christliche Kliniken Karlsruhe, Karlsruhe, Deutschland.

Whipple disease is an infection caused by the bacterium Tropheryma whipplei. Due to its unspecific clinical symptoms, it is difficult to diagnose and often remains undetected for a long time. The case of a patient who presented with acute intestinal symptoms to the authors' department is reported. Read More

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Case Report: Tropheryma whipplei Infection Presenting with Optic Disc Edema.

Optom Vis Sci 2020 Dec;97(12):1041-1047

Ophthalmology Clinic, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio.

Significance: Whipple disease is a rare chronic, systemic bacterial infection that predominantly affects the small intestine but also other organs of the body. When left untreated, it can be not only vision threatening but also life threatening because of its central nervous system involvement. Therefore, early detection and treatment are important. Read More

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December 2020

Pre-operative stenting and complications following pancreatoduodenectomy for pancreatic cancer: an analysis of the ACS-NSQIP registry.

Surg Endosc 2020 Nov 25. Epub 2020 Nov 25.

Department of General Surgery, London Health Sciences Centre, London, ON, Canada.

Background: Historically, pre-operative biliary stenting has been associated with higher infectious complication rates following pancreatoduodenectomy. However, alleviation of biliary obstruction is necessary for consideration of pre-operative chemotherapy, which may improve disease-free survival, or for mitigation of symptoms while awaiting surgery. Our aim is to compare contemporary post-operative complication risk among patients with pre-operative endoscopic retrograde cholangiopancreatography (ERCP) stenting compared to those without. Read More

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November 2020

Gastrointestinal and renal involvement in systemic vasculitis.

Rev Esp Enferm Dig 2020 Dec;112(12):952-953

Gastroenterology, Centro Hospitalar Vila Nova de Gaia e Espinho, Portugal.

Vasculitis can also present with GI or solid organ involvement. IgA and ANCA associated vasculitis are more likely to have GI involvement. A 56-year-old female was admitted to the ER due to nausea, vomiting, epigastric pain and fever. Read More

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December 2020