Search Our Scientific Publications & Authors

Ophthalmic Res 2018 Dec 6:1-5. Epub 2018 Dec 6.

Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu,

Purpose: To evaluate the efficacy of bilateral lateral rectus muscle recession (BLR) to treat recurrent exotropia after bilateral medial rectus muscle resection (BMR).

Methods: Twenty-four patients who underwent BLR for recurrent exotropia and were followed up for more than 6 months were included in this retrospective study. All of them had prior BMR. Read More

Epilepsy Behav 2018 Dec 3;90:99-106. Epub 2018 Dec 3.

Population, Policy and Practice Unit, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.

Background: Sudden Unexpected Death in Epilepsy (SUDEP) is a significant cause of death in childhood epilepsy, and causes considerable concern to patients and their families. Despite this, the condition remains poorly understood. This systematic review investigates the risk factors, pathophysiology, and circumstances associated with childhood SUDEP. Read More

Drug Alcohol Depend 2018 Dec 3;194:482-486. Epub 2018 Dec 3.

Department of Academic Affairs, Baystate Medical Center, 3601 Main St., Springfield, MA 01199, United States. Electronic address:

Background: Criminal justice involved (CJS) populations with opioid use disorder (OUD) have high rates of relapse, future arrests, and death upon release. While medication for OUD (MOUD) reduces opioid relapse, concerns regarding diversion and stigma limit treatment in CJS populations. Extended release naltrexone (XR-NTX), as an opioid antagonist, may be more acceptable to CJS administrators. Read More

Midwifery 2018 Nov 23;69:158-162. Epub 2018 Nov 23.

Nursing Department of Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, No.2699, West Gaoke Road, Pudong New Area, Shanghai 201204, China.

Background: Depression is the most prevalent psychiatric disease during and after pregnancy (Aktas and Yesilcicek, 2015). Social supportive system (SSS) serves to protect against the development of depressive symptoms (Moshki and Cheravi, 2016). The mitigating effect of SSS on depression among expectant Chinese women is unclear. Read More

Clin Neurophysiol 2018 Nov 26;130(1):111-121. Epub 2018 Nov 26.

Department of Linguistics and Languages, McMaster University, Togo Salmon Hall 513, 1280 Main Street, West Hamilton, ON L8S 4M2, Canada; ARiEAL Research Centre, McMaster University, L.R. Wilson Hall, 1280 Main Street, West Hamilton, ON L8S 4M2, Canada; School of Biomedical Engineering, McMaster University, ETB-406, 1280 Main St., West Hamilton, ON L8S 4K1, Canada; MaRS Centre, Vector Institute, Canada; McMaster University, Department of Psychology, Neuroscience and Behaviour, Canada. Electronic address:

Objective: Recent studies demonstrate that sports-related concussions can have negative consequences on long-term brain health. The goal of the present study was to determine whether retired Canadian Football League (CFL) athletes with a history of concussions exhibit alterations in neurocognitive functioning, along with changes in physical, social, and psychological health.

Methods: Our study compared nineteen retired CFL athletes' concussion histories to eighteen healthy age-matched controls with no history of concussion. Read More

J Thorac Oncol 2018 Dec 3. Epub 2018 Dec 3.

Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou, China. Electronic address:

Introduction: Adjuvant gefitinib therapy prolonged disease-free survival (DFS) in patients with resected early-stage epidermal growth factor receptor (EGFR)-mutation positive non-small cell lung cancer (NSCLC) in the ADJUVANT study (CTONG 1104). However, treatment failure patterns after gefitinib therapy are less well characterized.

Methods: Overall, 222 stage N1-N2, EGFR-mutant NSCLC patients received gefitinib or vinorelbine plus cisplatin (VP) treatment. Read More

Fitoterapia 2018 Dec 3. Epub 2018 Dec 3.

Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Medicine, Shenzhen University Health Science Center, Shenzhen 518060, People's Republic of China. Electronic address:

Nine multifarious new meroterpenoids, cochlearols E-M (1-9), along with seven known meroterpenoids 10-16, were isolated from the fruiting bodies of Ganoderma cochlear. Racemic 1, 6-8, 10 and 13 were separated by chiral HPLC. The structures were elucidated based on detailed spectroscopic analyses (HRESIMS, 1D/2D-NMR) and calculated electronic circular dichroism (ECD). Read More

Fitoterapia 2018 Dec 3. Epub 2018 Dec 3.

Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, PR China. Electronic address:

Two new nucleoside derivatives, named asponguanosines A and B (1 and 2), three new N-acetyldopamine analogues, aspongamides C-E (3-5), one new sesquiterpene, aspongnoid D (6), and three known compounds were isolated from the medicinal insect Aspongopus chinensis. Their structures including absolute configurations were assigned by using spectroscopic methods and ECD and C NMR calculations. Biological activities of compounds 3-7 towards human cancer cells, COX-2, ROCK1, and JAK3 were evaluated. Read More

Cochrane Database Syst Rev 2018 Dec 4;12:CD009458. Epub 2018 Dec 4.

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, No. 20, Section Three, Ren Min Nan Lu Avenue, Chengdu, Sichuan, China, 610041.

Background: Endometrial carcinoma is the most common gynaecologic malignancy in the world and develops through preliminary stages of endometrial hyperplasia. Atypical endometrial hyperplasia suggests a significant pre-malignant state with frank progression to endometrial carcinoma, and tends to occur at a young age. Oral progestins have been used as conservative treatment in young women with atypical endometrial hyperplasia, but they are associated with poor tolerability and side effects that may limit their overall efficacy. Read More

PLoS One 2018 6;13(12):e0208571. Epub 2018 Dec 6.

Haaglanden Medical Center, The Hague, the Netherlands.

Aim: Increasing evidence exists with respect to the relation between stressful life events and functional constipation (FC). We aimed to investigate the prevalence of FC in Palestinian refugee preschool children and to determine if stress and trauma exposure are risk factors of FC in these children.

Methods: From November 2013 until May 2014, a cross-sectional survey was conducted in West Bank, Gaza and Jordan. Read More

PLoS One 2018 6;13(12):e0208435. Epub 2018 Dec 6.

Occupational and environmental medicine, Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Recurrent headache, abdominal and musculoskeletal pain are common in adolescents and it is therefore important to understand their impact on the transitional period from childhood to adulthood. However, studies of the prevalence over time and implications on educational outcomes are still limited, especially regarding multiple pain symptoms. The present study material consists of questionnaire surveys, completed in 2000 and 2008, including two study populations of 9th grade adolescents aged 15 living in West Sweden (n = 20 877). Read More

PLoS One 2018 6;13(12):e0207406. Epub 2018 Dec 6.

Tropical and Infectious Diseases Department, Centre Hospitalier Andrée Rosemon, Cayenne, French Guiana.

Background: French Guiana (FG) was the first country in South America to declare chikungunya virus infection (CHIKV). The outbreak affected about 16,000 persons between February 2014 and October 2015, with several atypical cases, but only two fatal cases. We aimed to describe the clinical presentation of patients hospitalized for CHIKV infection, to estimate and identify risk factors of unusual and severe forms in adult patients. Read More

PLoS One 2018 6;13(12):e0207571. Epub 2018 Dec 6.

Wellcome Trust Brighton & Sussex Centre for Global Health Research, Brighton & Sussex Medical School, Falmer, Brighton, United Kingdom.

Background: Intimate Partner Violence (IPV) is a serious, preventable public health problem that affects millions of people worldwide. Research indicates that adults suffering from long term, disabling conditions are more likely to be victims of IPV due to the intersection of disease-associated stigma and discrimination. IPV in turn is known to worsen the overall health and wellbeing of those affected by it. Read More

Br J Community Nurs 2018 Dec;23(12):582-588

Consultant nurse, physical healthcare, West London Mental Health Trust.

Faecal incontinence (FI) is a hidden problem that is under-diagnosed, under-investigated and under treated. Up to 10% of adults can experience an episode of FI. The prevalence of FI in the adult population has been estimated at 0. Read More

Aging Ment Health 2018 Dec 6:1-7. Epub 2018 Dec 6.

a Department of Pharmaceutical Systems and Policy , West Virginia University , Morgantown , WV , USA.

Background: Antipsychotic medication use among elderly with Alzheimer's disease and related dementias (ADRD) and without severe mental illness is considered as low-value care. Our objective was to assess the factors associated with this inappropriate use of antipsychotic medications among community-dwelling Medicare beneficiaries with ADRD and without severe mental illness.

Methods: This study used a retrospective cross-sectional design. Read More

Br J Community Nurs 2018 Dec;23(Sup12):S6-S12

Professor and Director for the Institute of Skin Integrity and Infection prevention, Department of Nursing and Midwifery, University of Huddersfield, Queensgate, Huddersfield, West Yorkshire.

Chronic wounds are associated with a significant patient, healthcare and financial burden and can have extensive implications for healthcare. Age is a significant risk factor for developing chronic wounds, due to physical changes in skin integrity and several age-related complex comorbidities, including poor nutrition and mobility. Pressure ulcers (PU) are a common type of chronic wound that can have a substantial impact on health-related quality of life and patient outcomes. Read More

Clin Anat 2018 Dec 6. Epub 2018 Dec 6.

Seattle Science Foundation, Seattle, WA, USA.

The field of stem cell biology is exciting because it provides researchers and clinicians with seemingly unlimited applications for treating many human diseases. Stem cells are a renewable source of pluripotent cells that can differentiate into nearly all human cell types. In this article we focus particularly on human embryonic stem (hES) cells, derived from the inner cell mass of the blastocyst and cultured for expansion while remaining undifferentiated, to explore their unique molecular personalities and clinical applications. Read More

New Phytol 2018 Dec 6. Epub 2018 Dec 6.

Department of Plant Sciences, University of Cambridge, Cambridge, CB2 3EA, UK.

High efficiency methods for DNA assembly have enabled routine assembly of synthetic DNAs of increased size and complexity. However, these techniques require customisation, elaborate vector sets or serial manipulations for the different stages of assembly. We have developed Loop assembly based on a recursive approach to DNA fabrication. Read More

Int J Cancer 2018 Dec 6. Epub 2018 Dec 6.

Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20133 Milan, Italy.

Diets rich in vegetables and fruit have been associated with reduced risk of gastric cancer, and there is suggestive evidence that citrus fruits have a protective role. This study aimed at evaluating and quantifying the association between citrus fruit consumption and gastric cancer risk. We conducted a one-stage pooled analysis including 6340 cases and 14,490 controls from 15 case-control studies from the Stomach cancer Pooling (StoP) Project consortium. Read More

Cancer 2018 Dec 6. Epub 2018 Dec 6.

Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia.

Background: Depression is highly prevalent in lung cancer. Although there is a known association between inflammation and depression, this relationship has not been examined in patients with lung cancer who undergo treatment with immune and other targeted drug therapies. Peripheral blood C-reactive protein (CRP), a marker of systemic inflammation, may help identify metastatic lung cancer patients with inflammation-associated depression. Read More

Sleep 2018 Dec 5. Epub 2018 Dec 5.

CRUK Clinical Trials Unit, Institute of Cancer Sciences, University of Glasgow.

Study Objectives: Insomnia in cancer patients is prevalent, persistent and confers risk for physical and psychological disorder. We must better understand how insomnia develops in cancer patients and explore the main contributors to its chronicity so that insomnia management protocols can be integrated more effectively within cancer care. This study monitors the etiology of insomnia in breast cancer patients and identifies risk factors for its persistence. Read More

Bioinformatics 2018 Dec 6. Epub 2018 Dec 6.

Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.

Motivation: Small p-values are often required to be accurately estimated in large-scale genomic studies for the adjustment of multiple hypothesis tests and the ranking of genomic features based on their statistical significance. For those complicated test statistics whose cumulative distribution functions are analytically intractable, existing methods usually do not work well with small p-values due to lack of accuracy or computational restrictions. We propose a general approach for accurately and efficiently estimating small p-values for a broad range of complicated test statistics based on the principle of the cross-entropy method and Markov chain Monte Carlo sampling techniques. Read More

J Clin Endocrinol Metab 2018 Dec 5. Epub 2018 Dec 5.

Molecular Thyroid Research Laboratory, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany.

Context: The Major Histocompatibility Complex (MHC) strongly contributes to the development of polyglandular autoimmunity (PGA).

Objective: To evaluate the impact of gender on human leukocyte antigen (HLA) association with PGA for the first time.

Design: Cross-sectional immunogenetic study. Read More

JAMA Oncol 2018 Dec 6. Epub 2018 Dec 6.

Swedish Cancer Institute, Seattle, Washington.

Org Biomol Chem 2018 Dec 6. Epub 2018 Dec 6.

Tianjin Key Laboratory for Photoelectric Materials and Devices, and Key Laboratory of Display Materials and Photoelectric Devices, Ministry of Education, School of Materials Science & Engineering, Tianjin University of Technology, Tianjin 300384, China. and School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, China.

Hypochlorous acid (HOCl) has been known to be intertwined with various pathophysiological processes. In this paper, a novel mitochondria-targeted near-infrared (NIR) fluorescent probe L based on a chromenylium-phenothiazine conjugate has been designed and synthesized for the detection of hypochlorous acid. Due to the HOCl-promoted intramolecular charge transfer processes, the probe L shows near-infrared fluorescence emission at 672 nm, large Stokes shifts of 97 nm, fast response, and high selectivity and sensitivity. Read More

Analyst 2018 Dec 6. Epub 2018 Dec 6.

State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, Beijing, 100084, China and Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA and Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.

Direct sampling mass spectrometry (MS) has been advancing aggressively, showing immense potential in translating MS into the clinical field. Unlike traditional MS analysis involving extensive sample preparation and chromatographic separation, quick and simple procedures with minimal sample pretreatment or purification became available with direct sampling. An overview of the development in this field is provided, including some representative ambient ionization and fast extraction methods. Read More

Am J Surg Pathol 2018 Dec 4. Epub 2018 Dec 4.

Department of Pathology, Stanford University School of Medicine, Stanford, CA.

The spectrum of tumors arising in the salivary glands is wide and has recently been shown to harbor a network of tumor-specific fusion genes. Acinic cell carcinoma (AciCC) is one of the more frequently encountered types of salivary gland carcinoma, but it has remained a genetic orphan until recently when a fusion between the HTN3 and MSANTD3 genes was described in one case. Neither of these 2 genes is known to be implicated in any other malignancy. Read More

Cancer Nurs 2019 Jan/Feb;42(1):86-87

Author Affiliation: Yale University School of Nursing, West Haven, Connecticut.

Br J Psychiatry 2018 Dec 6:1-9. Epub 2018 Dec 6.

Clinical Senior Lecturer in Mood Disorders and Consultant Psychiatrist,National Affective Disorders Service; Academic Psychiatry Training Programme Lead,Institute of Psychiatry,Psychology and Neuroscience,King's College London,South London and Maudsley NHS Foundation Trust (SLaM); andCRN South London Lead for Mental Health,Centre for Affective Disorders, Institute of Psychiatry,Psychology and Neuroscience,King's College London,South London and Maudsley NHS Foundation Trust (SLaM),UK.

Background: Most people with bipolar disorder spend a significant percentage of their lifetime experiencing either subsyndromal depressive symptoms or major depressive episodes, which contribute greatly to the high levels of disability and mortality associated with the disorder. Despite the importance of bipolar depression, there are only a small number of recognised treatment options available. Consecutive treatment failures can quickly exhaust these options leading to treatment-resistant bipolar depression (TRBD). Read More

J Neurotrauma 2018 Dec 6. Epub 2018 Dec 6.

ICORD/UBC, Medicine , 6270 University Blv. , Vancouver, British Columbia, Canada , V6T 1Z4.

N/a. Read More

Ir Med J 2018 08 13;111(7):787. Epub 2018 Aug 13.

Academic Department of Medicine, National University of Ireland Galway, University Road, Galway, Ireland.

Aim This study aims to describe the perceptions of young adults’, parents of young adults’ and health care professionals’ (HCPs) of the transition process for young adults with Type 1 Diabetes in the West of Ireland. Methods Thematic analysis of semi-structured interviews conducted with the three stakeholder groups was performed. Results Young adults hardly noticed the transition, with many of them seeing it as a physical move, whereas parents were more anxious and felt their involvement was still needed but not accommodated. Read More

Transbound Emerg Dis 2018 Dec 6. Epub 2018 Dec 6.

Center of Conservation Medicine & Ecological Safety, Northeast Forestry University, Harbin, 150040, Heilongjiang province, P. R. China.

African swine fever (ASF) is a transcontinental, contagious, fatal virus disease of pig with devastating socioeconomic impacts. Interaction between infected wild boar and domestic pig may spread the virus. The disease is spreading fast from the west of Eurasia towards ASF-free China. Read More

Dermatol Ther 2018 Dec 5:e12796. Epub 2018 Dec 5.

Farabi Building, Isfahan, Iran.

Recently, advances in understanding the etiology of urticaria and updates of diagnostic and therapeutic management guidelines have drawn attention to chronic urticaria (CU) morbidity. This study aimed to evaluate Iranian dermatologists' practice and real life management of CU patients. A total of 35 dermatologists and 443 patients were included in the study. Read More

Genes Chromosomes Cancer 2018 Dec 5. Epub 2018 Dec 5.

Institute of Pathology, Hannover Medical School, Hannover, Germany.

HER2-positive breast cancer is defined by amplification or overexpression of the HER2/ERBB2 oncogene and accounts for about 15% of breast cancer (BC) cases. Somatic mutation of ERBB2 is an alternative mechanism, by which activation of HER2 signaling can occur. ERBB2 mutation has been associated with invasive lobular breast cancer (ILBC). Read More

J Vet Intern Med 2018 Dec 5. Epub 2018 Dec 5.

Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York.

Background: Three flaviviruses (equine pegivirus [EPgV]; Theiler's disease-associated virus [TDAV]; non-primate hepacivirus [NPHV]) and equine parvovirus (EqPV-H) are present in equine blood products; the TDAV, NPHV, and EqPV-H have been suggested as potential causes of serum hepatitis.

Objective: To determine the prevalence of these viruses in horses with equine serum hepatitis.

Animals: Eighteen horses diagnosed with serum hepatitis, enrolled from US referral hospitals. Read More

Chirality 2018 Dec 6. Epub 2018 Dec 6.

Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou, China.

Enantioselective vinylation of aldehydes via direct catalytic asymmetric Grignard reaction of aldehdyes and the vinyl Grinard reagent is a long-standing challenge. This work demonstrated that the magnesium (S)-3,3'-dimethyl BINOLate enantioselectively catalyze the direct vinylation of aldehydes with the deactivated vinylmagnesium bromide by bis(2-[N,N'-dimethylamino]ethyl) ether (BDMAEE) in the addition of n-butylmagnesium chloride. The highest ee of 63% was achieved up to date. Read More

Am J Ind Med 2018 Dec 5. Epub 2018 Dec 5.

Division of Health and Nutrition Examination Surveys, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland.

Introduction: This study estimated the prevalence of spirometry-defined airflow obstruction by industry and occupation and chronic obstructive pulmonary disease (COPD) among ever-employed U.S. adults. Read More

J Clin Lab Anal 2018 Dec 5:e22724. Epub 2018 Dec 5.

Department of Neurosurgery, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region, Chengdu, China.

Background: This study aimed to evaluate the predictive value of presurgical factors for psychiatric disorders (PD) in refractory temporal lobe epilepsy and mesial temporal sclerosis (TLE-MTS) patients underwent cortico-amygdalohippocampectomy (CAH).

Methods: A total of 98 refractory TLE-MTS patients underwent CAH were consecutively enrolled in this cohort study. Several presurgical factors were recorded, such as married status, employment status, highest education, disease duration, family history of epilepsy, and disorganized VEEG background activity. Read More

J Neurochem 2018 Dec 6. Epub 2018 Dec 6.

Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Morgantown, WV.

Improper protein folding and trafficking are common pathological events in neurodegenerative diseases that result in the toxic accumulation of misfolded proteins within the lumen of the endoplasmic reticulum (ER). While low-level stimulation of the unfolded protein response (UPR) is protective, sustained UPR activation resulting from prolonged ER stress can promote neurotoxicity. The cell-autonomous mechanisms of the UPR have been extensively characterized. Read More

J Comp Neurol 2018 Dec 6. Epub 2018 Dec 6.

Department of Biological Sciences, Purdue University, West Lafayette, Indiana.

Class III Semaphorin (Sema) secreted ligands are known to repel neurites expressing Neuropilin (Nrp) and/or Plexin (Plxn) receptors. There is, however, a growing body of literature supporting that Sema signaling also has alternative roles in development such as synaptogenesis, boundary formation and vasculogenesis. To evaluate these options during inner ear development, we used in situ hybridization or immunohistochemistry to map the expression of Sema3D, Sema3F, Nrp1, Nrp2, and PlxnA1 in the chicken (Gallus gallus) inner ear from embryonic day (E)5 to E10. Read More

Fish Physiol Biochem 2018 Dec 5. Epub 2018 Dec 5.

Department of Applied Microbiology and Biotechnology, Faculty of Food Science and Fisheries, West Pomeranian University of Technology, Papieza Pawla VI 3, 71-450, Szczecin, Poland.

Defense mechanisms of fish are investigated in many aspects. One of the most interesting systems is that based on non-specific immune factors whose mechanisms of biocontrol have evolved in complex processes of microbiological co-existence. The wild fish devoid of probiotic stimulation have developed their own system to control the biosynthesis of immunostimulating compounds based on commensal microflora. Read More

EJNMMI Phys 2018 Dec 5;5(1):34. Epub 2018 Dec 5.

Biomedical Imaging Science Department, School of Medicine, University of Leeds, Leeds, West Yorkshire, UK.

Background: Positron emission tomography (PET) imaging has a wide applicability in oncology, cardiology and neurology. However, a major drawback when imaging very active regions such as the bladder is the spill-in effect, leading to inaccurate quantification and obscured visualisation of nearby lesions. Therefore, this study aims at investigating and correcting for the spill-in effect from high-activity regions to the surroundings as a function of activity in the hot region, lesion size and location, system resolution and application of post-filtering using a recently proposed background correction technique. Read More

Neotrop Entomol 2018 Dec 5. Epub 2018 Dec 5.

Coordenação de Biodiversidade, Lab de Sistemática e Ecologia de Coleoptera, Instituto Nacional de Pesquisas da Amazônia, Av. André Araújo, N° 2936, campus II, caixa postal 478, CEP 69011-970, Aleixo Manaus, Amazonas, Brasil.

We present a list of Passalidae species found in the westmost Brazilian Amazon region, which is considered to be a diversity-rich area due to being a tectonic and geographic transition zone in relation to Brazilian Amazon lowlands and the Andean range. The specimens acquired in field collections and museums were analyzed. Their geographical distributions were estimated based on data from labeled specimens and the literature. Read More

Environ Sci Pollut Res Int 2018 Dec 5. Epub 2018 Dec 5.

Department of Microbiology, SVKM's Mithibai College of Arts, Chauhan Institute of Science & Amrutben Jivanlal College of Commerce and Economics, Vile Parle West, Mumbai, Maharashtra, 400056, India.

Biodiesel production from microalgae has been researched extensively and attempted to commercialize on a large scale, but there are major hurdles in the production process like harvesting and low lipid content, which should be studied to enhance the process and make it economical. Present study aimed to improve the lipid productivity of Chlorella minutissima and Chlorella pyrenoidosa by modifying the carbon and nitrogen content of the medium. Both organisms were grown in BG11 medium for the first 6 days and thereafter grown in a modified BG11 medium completely deprived of nitrogen for 2 to 10 days. Read More

Virus Genes 2018 Dec 5. Epub 2018 Dec 5.

Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Science, 666 Liuying Xi Road, Changchun, 130122, China.

Feline panleukopenia virus (FPV) infects cats and can be fatal to kittens. There is evidence that canine parvovirus originated from FPV, which makes FPV important in studies of the family Parvoviridae. In the present study, the entire genome of FPV strain HH-1/86 was converted into a full-length infectious clone (pFPV). Read More

Mol Divers 2018 Dec 5. Epub 2018 Dec 5.

College of Science, China Agricultural University, No. 2, Yuanmingyuan West Road, Haidian District, Beijing, 100193, China.

1,1-Diaryl compounds are a series of compounds which possess two aryl groups attached to a central carbon atom. This special structure made it as a very important module in bioactive molecules, and compounds of this type are numerous. 1,1-Diaryl derivatives can be used as catalysts in chemical synthesis, chemical probes and biologically active molecules for medicines and pesticides. Read More

Theor Appl Genet 2018 Dec 5. Epub 2018 Dec 5.

National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.

Key Message: We developed breeder-friendly high-throughput and cost-effective KASP marker for marker-assisted selection for grain yield related traits in wheat. Plant-specific protein kinase, SnRK2s, is a major family of signaling genes associated with metabolic regulations, nutrient utilization and response to external stimuli. In the present study, three copies of TaSnRK2. Read More

Open Med (Wars) 2018 25;13:565-574. Epub 2018 Nov 25.

Department of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University, Szczecin, Poland.

Ovarian cancer is characterised by the greatest mortality among all tumors of the reproductive tract. This study included 246 patients which consisted of 136 women with ovarian cancer without genetic mutation and 110 women with benign ovarian cysts. We created two mathematical logic models containing positive and negative risk factors of ovarian cancer such as: age at last menstruation cycle, patient age, OC, HRT, smoking, education status, and alcohol consumption. Read More

Biomed Res Int 2018 4;2018:8305927. Epub 2018 Nov 4.

Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center and Postgraduate School Molecular Medicine, Rotterdam, Netherlands.

[This corrects the article DOI: 10.1155/2018/6751952.]. Read More

ERJ Open Res 2018 Oct 3;4(4). Epub 2018 Dec 3.

Dept of Research and Education, CIRO+, Center of Expertise for Chronic Organ Failure, Horn, The Netherlands.

http://ow.ly/2HER30mxLLj. Read More