367,294 results match your criteria West Nile Encephalitis


Lennox-Gastaut Syndrome in Mitochondrial Disease.

Yonsei Med J 2019 Jan;60(1):106-114

Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.

Purpose: Previous studies have shown that neurologic symptoms are dominant in patients with mitochondrial diseases, and most of these patients have seizure-related disorders. The epileptic classification of these patients as Lennox-Gastaut syndrome (LGS) is as high as 25%. This study aimed to investigate the clinical manifestations, diagnoses, treatments, and epilepsy in LGS, which is associated with mitochondrial disease. Read More

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January 2019

Oceanobacillus timonensis sp. nov. and Oceanobacillus senegalensis sp. nov., two new moderately halophilic, Gram-stain positive bacteria isolated from stools sample of healthy young Senegalese.

Antonie Van Leeuwenhoek 2018 Dec 15. Epub 2018 Dec 15.

Aix Marseille Univ, IRD, AP-HM, MEPHI, IHU Méditerranée Infection, Marseille, France.

Oceanobacillus timonensis Marseille-P3532 (CSUR P3532, CCUG 70981) and Oceanobacillus senegalensis Marseille-P3587 (CSUR P3587, CCUG 70613), are the type strains of O. timonensis sp. nov. Read More

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December 2018
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Epidemiology of gastrostomy insertion for children and adolescents with intellectual disability.

Eur J Pediatr 2018 Dec 15. Epub 2018 Dec 15.

Telethon Kids Institute, Centre for Child Health Research, The University of Western Australia, PO Box 855, West Perth, Western Australia, 6872, Australia.

The largest group of recipients of pediatric gastrostomy have neurological impairment with intellectual disability (ID). This study investigated trends in first gastrostomy insertion according to markers of disadvantage and ID etiology. Linked administrative and health data collected over a 32-year study period (1983-2014) for children with ID born between 1983 and 2009 in Western Australia were examined. Read More

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December 2018

Efficacy and Safety of CFTR Corrector and Potentiator Combination Therapy in Patients with Cystic Fibrosis for the F508del-CFTR Homozygous Mutation: A Systematic Review and Meta-analysis.

Adv Ther 2018 Dec 15. Epub 2018 Dec 15.

Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.

Introduction: Cystic fibrosis (CF) is a progressive, genetic disease that causes persistent lung infections and limits the ability to breathe over time. The combination of a cystic fibrosis transmembrane conductance regulator (CFTR) corrector and potentiator has provided a benefit by decreasing sweat chloride concentration in CF for the F508del-CFTR homozygous mutation, but it remains controversial in lung function, nutritional status, clinical score and safety.

Methods: The authors performed a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy and safety of combination therapy on lung function, nutritional status, clinical score and safety in CF for the F508del-CFTR homozygous mutation. Read More

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December 2018
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Translation of basic research in cognitive science to HIV-risk: a randomized controlled trial.

J Behav Med 2018 Dec 15. Epub 2018 Dec 15.

Department of Psychiatry and Behavioral Sciences, University of Washington, 1100 NE 45th Street, Suite 300, Box 354944, Seattle, WA, 98195-4944, USA.

Many people enrolled in drug diversion programs are not receiving evidence-based prevention for HIV or hepatitis. This study translated basic research from cognitive science to increase screening for infection and condom use in this population. A parallel three-condition randomized trial was conducted in a drug diversion sample (N = 358), comparing a memory practice condition with two active control conditions. Read More

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December 2018
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Playing Super Mario increases oculomotor inhibition and frontal eye field grey matter in older adults.

Exp Brain Res 2018 Dec 15. Epub 2018 Dec 15.

Centre de Recherche en Neuropsychologie et Cogntion, University of Montreal, Pavillon Marie-Victorin 90, Avenue Vincent d'Indy, Montreal, QC, H2V 2S9, Canada.

Aging is associated with cognitive decline and decreased capacity to inhibit distracting information. Video game training holds promise to increase inhibitory mechanisms in older adults. In the current study, we tested the impact of 3D-platform video game training on performance in an antisaccade task and on related changes in grey matter within the frontal eye fields (FEFs) of older adults. Read More

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December 2018

Yield of peripheral sodium channels gene screening in pure small fibre neuropathy.

J Neurol Neurosurg Psychiatry 2018 Dec 15. Epub 2018 Dec 15.

Department of Clinical Genetics, Maastricht University Medical Centre, Maastricht, The Netherlands

Background: Neuropathic pain is common in peripheral neuropathy. Recent genetic studies have linked pathogenic voltage-gated sodium channel (VGSC) variants to human pain disorders. Our aims are to determine the frequency of , and variants in patients with pure small fibre neuropathy (SFN), analyse their clinical features and provide a rationale for genetic screening. Read More

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December 2018
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Synthesis, structure activity relationship and in vitro anti-influenza virus activity of novel polyphenol-pentacyclic triterpene conjugates.

Eur J Med Chem 2018 Dec 7;163:560-568. Epub 2018 Dec 7.

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic address:

It is urgently necessary to develop more effective anti-influenza agents due to the continuous emergence of drug-resistant strains of influenza virus. Our earlier studies have identified that certain pentacyclic triterpene derivatives are effective inhibitors of influenza virus infection. In the present study, a series of C-28 modified pentacyclic triterpene derivatives via conjugation with a series of polyphenols were synthesized, and their antiviral activities against influenza A/WSN/33 (H1N1) virus in MDCK (Madin-Darby canine kidney) cells were evaluated. Read More

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December 2018
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"It's about bloody time": Perceptions of people who use drugs regarding drug law reform.

Int J Drug Policy 2018 Dec 13;64:40-46. Epub 2018 Dec 13.

Drug Policy Modelling Program, University of New South Wales, 22-32 King Street, Randwick NSW 2031, Australia.

Background: In Australia and elsewhere, the impacts of drug prohibition have sparked a critical dialogue about the state of current drug laws. While a range of 'experts' have offered their opinion and participation in these deliberations, the voices of the affected community have largely been excluded. This study aimed to gather the opinions and preferences of people who use drugs about the current or alternative models of drug laws, in addition to how they think drug laws could be changed Author Conflict of Interest Declaration. Read More

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December 2018

Adaptation of Rabensburg virus (RBGV) to vertebrate hosts by experimental evolution.

Virology 2018 Dec 13;528:30-36. Epub 2018 Dec 13.

The Arbovirus Laboratory, Wadsworth Center, New York State Department of Health, Slingerlands, NY, USA; Department of Biomedical Sciences, State University of New York at Albany School of Public Health, Albany, NY, USA.

Rabensburg virus (RBGV; Flaviviridae, Flavivirus) has been classified as both a novel flavivirus and a unique lineage of West Nile virus (WNV). RBGV and WNV share approximately 76% sequence homology, yet RBGV does not replicate to high viral titers within vertebrate cell lines at physiological temperatures and has not been naturally isolated from a vertebrate host. These unique genetic and biological characteristics make RBGV a viable tool to identify the genetic determinants of flavivirus infectivity and fitness in vertebrate hosts. Read More

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December 2018
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Emigration and alcohol consumption among migrant household members staying behind: Evidence from Kyrgyzstan.

Soc Sci Med 2018 Dec 8;221:40-48. Epub 2018 Dec 8.

University of the West of England, UK; Institute of Labor Economics (IZA), Germany. Electronic address:

Despite the growth of alcohol consumption and international migration in many developing countries, the links between the two remain underexplored. We study the relationship between emigration of household members, receiving remittances (migrant monetary transfers), and alcohol consumption of migrant household members staying behind in Kyrgyzstan, a poor post-socialist country that has recently witnessed both large-scale emigration and a rise in alcohol-related health problems. Using a large longitudinal survey, we find that, among the ethnic majority (Kyrgyz), an increase in migrant remittances is associated with a higher likelihood and frequency of consuming alcohol, as well as an increase in the consumption of beer. Read More

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December 2018

Long-term disability in neuromyelitis optica spectrum disorder with a history of myelitis is associated with age at onset, delay in diagnosis/preventive treatment, MRI lesion length and presence of symptomatic brain lesions.

Mult Scler Relat Disord 2018 Dec 9;28:64-68. Epub 2018 Dec 9.

Johns Hopkins University, School of Medicine, Department of Neurology, Baltimore, MD, USA.

Background: Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease of the central nervous system (CNS) that preferentially targets the spinal cord and optic nerves. Increasing disability is accrued with each inflammatory attack. Disability has been shown to be an independent predictor of poor quality of life in those with NMOSD. Read More

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December 2018

Predictive validity of hypodensities on non-contrast computed tomography for hematoma growth in intracerebral hemorrhage: a meta-analysis.

World Neurosurg 2018 Dec 13. Epub 2018 Dec 13.

Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China. Electronic address:

Objective: Intracerebral hemorrhage (ICH) is a kind of stroke which leads to high mortality. Hematoma growth (HG) happens in about one third of all ICH patients and independently related to poor outcome. Previous studies have shown that an indicator on non-contrast computed tomography (NCCT), called hypodensities, can predict HG in ICH patients. Read More

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December 2018

How do manual handling advisors and physiotherapists construct their back beliefs, and do safe lifting posture beliefs influence them?

Musculoskelet Sci Pract 2018 Dec 1;39:101-106. Epub 2018 Dec 1.

Centre for Applied Research in Health, University of Huddersfield, HD1 3DH, UK; South West Yorkshire Partnership NHS Foundation Trust, UK.

Background: The Back-Pain Attitudes (Back-PAQ) questionnaire measures back beliefs across 6 domains. Our previous study showed that manual handling advisors (MHAs) have more negative beliefs than physiotherapists (PTs), and those who think straight back lifting is safer than a rounder back have more negative beliefs. However, exactly which domains of the Back-PAQ are most negative is unknown. Read More

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December 2018

Plio-Pleistocene diversification and biogeographic barriers in southern Australia reflected in the phylogeography of a widespread and common lizard species.

Mol Phylogenet Evol 2018 Dec 13. Epub 2018 Dec 13.

College of Science and Engineering, Flinders University, South Australia; Evolutionary Biology Unit, South Australian Museum.

Palaeoclimatic events and biogeographical processes since the mid-Tertiary have played an important role in shaping the evolution and distribution of Australian fauna. However, their impacts on fauna in southern and arid zone regions of Australia are not well understood. Here we investigate the phylogeography of an Australian scincid lizard, Tiliqua rugosa, across southern Australia using mitochondrial DNA (mtDNA) and 11 nuclear DNA markers (nuDNA), including nine anonymous nuclear loci. Read More

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December 2018

Accuracy of IP-10 for diagnosing latent tuberculosis infection: a systematic review and meta-analysis.

Clin Microbiol Infect 2018 Dec 13. Epub 2018 Dec 13.

Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Sichuan University, Chengdu, China. Electronic address:

Background: Effective diagnostic methods for detecting latent tuberculosis infection (LTBI) are important for its eradication. A number of studies have evaluated the use of interferon gamma-induced protein 10 (IP-10), which is elevated after tuberculosis infection, as a biomarker for LTBI, but conclusive results regarding its effectiveness have not been reported.

Objectives: Our objective was to assess the diagnostic value of IP-10 for LTBI. Read More

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December 2018

Effect of polymer concentration and solution pH on viscosity affecting integrity of a polysaccharide coat of compression coated tablets.

Int J Biol Macromol 2018 Dec 13. Epub 2018 Dec 13.

Division of Pharmaceutics, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, West Bengal, India.

Tablets, compression coated with certain polysaccharides and intended for colon delivery, retain the integrity of the coat for an initial period of about 6 h (lag period) beyond which (post-lag period) the coat is degraded by colonic enzymes to induce drug release. This work was undertaken to investigate the factors which influence the integrity of the coat during the lag period. Core tablets containing two model drugs were compression coated with various amounts of carboxymethyl locust bean gum (CMLBG). Read More

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December 2018

Mortality, morbidity, and hospitalisations due to influenza lower respiratory tract infections, 2017: an analysis for the Global Burden of Disease Study 2017.

Authors:

Lancet Respir Med 2018 Dec 12. Epub 2018 Dec 12.

Background: Although the burden of influenza is often discussed in the context of historical pandemics and the threat of future pandemics, every year a substantial burden of lower respiratory tract infections (LRTIs) and other respiratory conditions (like chronic obstructive pulmonary disease) are attributable to seasonal influenza. The Global Burden of Disease Study (GBD) 2017 is a systematic scientific effort to quantify the health loss associated with a comprehensive set of diseases and disabilities. In this Article, we focus on LRTIs that can be attributed to influenza. Read More

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December 2018
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Uridine adenosine tetraphosphate and purinergic signaling in cardiovascular system: an update.

Pharmacol Res 2018 Dec 13. Epub 2018 Dec 13.

Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, the Netherlands.

Uridine adenosine tetraphosphate (UpA), biosynthesized by activation of vascular endothelial growth factor receptor (VEGFR) 2, was initially identified as a potent endothelium-derived vasoconstrictor in perfused rat kidney. Subsequently, the effect of UpA on vascular tone regulation was intensively investigated in arteries isolated from different vascular beds in rodents including rat pulmonary arteries, aortas, mesenteric and renal arteries as well as mouse aortas, in which UpA produces vascular contraction. In contrast, UpA produces vascular relaxation in porcine coronary small arteries and rat aortas. Read More

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December 2018
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Age-related changes in neural coding of envelope cues: peripheral declines and central compensation.

Neuroscience 2018 Dec 13. Epub 2018 Dec 13.

Department of Otolaryngology, Harvard Medical School, and Eaton-Peabody Laboratories, Massachusetts Eye and Ear Infirmary, Boston, MA, 02114, USA.

Aging listeners often experience difficulties in perceiving temporally complex acoustic cues in noisy environments. These difficulties likely have neurophysiological contributors from various levels of auditory processing. Cochlear synapses between inner hair cells and auditory nerve fibers exhibit a progressive decline with age which is not reflected in the threshold audiogram. Read More

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December 2018

Different patterns of white matter changes after successful surgery of mesial temporal lobe epilepsy.

Neuroimage Clin 2018 Dec 8:101631. Epub 2018 Dec 8.

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address:

Objectives: To explore the dynamic changes of white matters following anterior temporal lobectomy (ATL) in mesial temporal lobe epilepsy (MTLE) patients who achieved seizure-free at two-year follow-up.

Methods: Diffusion tensor imaging (DTI) was obtained in ten MTLE patients at five serial time points: before surgery, three months, six months, 12 months and 24 months after surgery, as well as in 11 age- and sex-matched healthy controls at one time point. Regions with significant postoperative fractional anisotropy (FA) changes and their dynamic changes were confirmed by comparing all preoperative and postoperative data using Tract-Based Spatial Statistics (TBSS). Read More

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December 2018

Aspects of in vivo endotracheal tube intracuff pressure in cats.

Vet Anaesth Analg 2018 Oct 13. Epub 2018 Oct 13.

Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.

Objectives: To determine the endotracheal tube cuff pressure produced with two inflation techniques, in two brands of endotracheal tube in cats. To determine the inspiratory pressure which produces an audible leak when the intracuff pressure is 30 cmHO.

Study Design: Prospective, clinical, randomized study. Read More

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October 2018

Machine Learning for Data-Driven Discovery: The Rise and Relevance.

JACC Cardiovasc Imaging 2018 Dec 6. Epub 2018 Dec 6.

Division of Cardiology, WVU Heart & Vascular Institute, West Virginia University, Morgantown, West Virginia.

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December 2018

Prospective US investigational device exemption trial of a sutureless aortic bioprosthesis: One-year outcomes.

J Thorac Cardiovasc Surg 2018 Oct 23. Epub 2018 Oct 23.

Department of Thoracic and Cardiovascular Surgery, Heart and Vascular Institute, Cleveland Clinic Abu Dhabi and Cleveland Clinic Foundation, Cleveland, Ohio.

Objectives: We performed a prospective, single-arm clinical trial approved under a Food and Drug Administration Investigational Device Exemption to assess safety and efficacy of Perceval, a sutureless bovine pericardial aortic valve representing the initial US experience.

Methods: From June 2013 to January 2015, 300 patients (mean age 76.7 ± 7. Read More

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October 2018
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Genomics, GPCRs and new targets for the control of insect pests and vectors.

Curr Opin Insect Sci 2018 Dec 30;30:99-106. Epub 2018 Aug 30.

Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907-2089, USA.

The pressing need for new pest control products with novel modes of action has spawned interest in small molecules and peptides targeting arthropod GPCRs. Genome sequence data and tools for reverse genetics have enabled the prediction and characterization of GPCRs from many invertebrates. We review recent work to identify, characterize and de-orphanize arthropod GPCRs, with a focus on studies that reveal exciting new functional roles for these receptors, including the regulation of metabolic resistance. Read More

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December 2018

Discharge destination following pancreaticoduodenectomy: A NSQIP analysis of predictive factors and post-discharge outcomes.

Am J Surg 2018 Dec 8. Epub 2018 Dec 8.

Department of Surgery, Brigham and Women's Hospital/ Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA; Department of Surgery, VA Boston Healthcare System, West Roxbury, MA, USA. Electronic address:

Introduction: Pancreaticoduodenectomy is a complex surgical procedure. The purpose of this study was to identify factors associated non-home discharge destination and to characterize outcomes after non-home discharge.

Methods: 10,719 pancreaticoduodenectomy cases contained in the National Surgical Quality Improvement Program (NSQIP) Targeted Pancreatectomy dataset (years 2014-2016) were examined with univariate and multivariate logistic regression. Read More

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December 2018

Physical, psychological and economic burden of two-wheel users after a road traffic injury: Evidence from intensive care units of three EU countries.

J Safety Res 2018 Dec 21;67:155-163. Epub 2018 Oct 21.

Laboratory of Health and Road Safety, Department of Social Work, School of Health and Social Welfare, Technological Educational Institute of Crete, Estavromenos, P.C. 71004 Heraklion, Greece. Electronic address:

Introduction: This study aimed to assess the physical, psychological, and economic burden shouldered by severely injured two-wheel users in three European countries as well as the cost resulting from their hospitalization.

Methods: A total of seven public hospitals were involved in three countries: Greece, Italy, and Germany. Participants enrolled during a 12-month period starting in April 2013. Read More

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December 2018

Pectin-grafted terpolymer superadsorbent via N-H activated strategic protrusion of monomer for removals of Cd(II), Hg(II), and Pb(II).

Carbohydr Polym 2019 Feb 13;206:778-791. Epub 2018 Nov 13.

Advanced Polymer Laboratory, Department of Polymer Science and Technology, Government College of Engineering and Leather Technology (Post-Graduate), Maulana Abul Kalam Azad University of Technology, Salt Lake, Kolkata 700106, West Bengal, India. Electronic address:

Pectin (PC)-g-[methacrylic acid (MAA)-co-3-(N-isopropylacrylamido)-2-methylpropanoic acid (NIPAMPA)-co-N-isopropylacrylamide (NIPA)] (i.e., PC-g-TP), a novel interpenetrating terpolymer network hydrogel of excellent physicochemical properties and reusability, was synthesized via grafting of PC and in situ strategic protrusion of third monomer, i. Read More

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February 2019

Soluble xyloglucan generates bigger bacterial community shifts than pectic polymers during in vitro fecal fermentation.

Carbohydr Polym 2019 Feb 10;206:389-395. Epub 2018 Nov 10.

Whistler Center for Carbohydrate Research and Department of Food Science, Purdue University, West Lafayette, USA. Electronic address:

Xyloglucans and pectic polymers can be obtained from a variety of plants ubiquitous in the human diet, however, their fermentability in the colon and consequent nutritional benefits are poorly understood. Here, we evaluated metabolite profiles and bacterial shifts during in vitro fecal fermentations of two isolated pectic polymers and a xyloglucan. Depending on their chemical structure, pectic polymers were more acetogenic or propiogenic. Read More

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February 2019

Preparation and evaluation of carboxymethyl chitosan-rhein polymeric micelles with synergistic antitumor effect for oral delivery of paclitaxel.

Carbohydr Polym 2019 Feb 29;206:121-131. Epub 2018 Oct 29.

Pharmacy College, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China. Electronic address:

An amphiphilic carboxymethyl chitosan-rhein (CR) conjugate was prepared, characterized, and evaluated as a potential carrier material for oral delivery of paclitaxel (PTX). CR conjugate self-assembled in aqueous environment into CR polymeric micelles (CR PMs). The drug loading capacity and entrapment efficiency of PTX-loaded CR PMs were 35. Read More

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February 2019

Ventilation/perfusion SPECT/CT in patients with severe and rigid scoliosis: An evaluation by relationship to spinal deformity and lung function.

Clin Neurol Neurosurg 2018 Dec 6;176:97-102. Epub 2018 Dec 6.

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 37 Guoxue Rd, Chengdu, 610041, China. Electronic address:

Objective: Structural changes of the spine and chest wall associated with SRS result in poor cardiopulmonary function. Comprehensive assessment of pulmonary function is extremely important for patients with SRS before a correction operation. We explore the changes of distribution of lung ventilation and perfusion function in patients with SRS using SPECT/CT and describe the relation between these changes with Cobb angle and FVC%. Read More

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December 2018

Housefly larvae (Musca domestica) significantly accelerates degradation of monensin by altering the structure and abundance of the associated bacterial community.

Ecotoxicol Environ Saf 2018 Dec 12;170:418-426. Epub 2018 Dec 12.

College of Veterinary Medicine, China Agricultural University, No. 2 Yuan Ming Yuan West Road, Hai Dian District, Beijing 100193, China. Electronic address:

Vermicomposting of livestock manure using housefly larvae is a promising biotechnology for waste reduction and control of antibiotic pollution. Monensin (MON), an ionophore polyether antibiotic (IPA), is widely used in broiler feed to control coccidiosis. However, MON residues in litter have become a major source of pollution in the environment. Read More

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December 2018
2 Reads

Demarcating the dirty work: Canadian Fertility professionals' use of boundary-work in contentious egg donation.

Authors:
Skye A Miner

Soc Sci Med 2018 Dec 1;221:19-26. Epub 2018 Dec 1.

Department of Sociology, McGill University, Room 712, Leacock Building, 855 Sherbrooke Street West, Montreal, QC, H3A 2T7, Canada. Electronic address:

The potential medical risks to egg donors, in addition to the concern over the commodification of life, has led to debates surrounding the ethics of paying donors. In Canada, payment for eggs is prohibited by law; however, what is considered payment is contentious and has yet to be defined. The lack of legislative clarity coupled with increased ethical concerns over paying a donor has shifted egg donation from a medically-controlled procedure to a legal and social endeavor involving multiple professionals. Read More

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December 2018

Medical populism.

Soc Sci Med 2018 Dec 7;221:1-8. Epub 2018 Dec 7.

University of Canberra, Australia. Electronic address:

Medical emergencies are staple features of today's 24/7 culture of breaking news. As politics becomes increasingly stylised, audiences fragmented, and established knowledge claims contested, health crises have become even more vulnerable to politicisation. We offer the vocabulary of medical populism to make sense of this phenomenon. Read More

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December 2018
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Fluorodeoxyglucose positron emission tomography studies of the schizophrenia spectrum: The legacy of Monte S. Buchsbaum, M.D.

Psychiatry Res 2018 Dec 7;271:535-540. Epub 2018 Dec 7.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Mental Illness Research, Education, and Clinical Center (VISN 2), James J. Peters VA Medical Center, 130 West Kingsbridge Road, Room 6A-44, Bronx, NY, United States.

This is a selective review of the work of Buchsbaum and colleagues. It revisits and pays tribute to four decades of publications employing positron emission tomography (PET) with fluorodeoxyglucose (FDG) to examine the neurobiology of schizophrenia-spectrum disorders (including schizotypal personality disorder (SPD) and schizophrenia). Beginning with a landmark FDG-PET study in 1982 reporting hypofrontality in unmedicated schizophrenia patients, Buchsbaum and colleagues published high-impact work on regional glucose metabolic rate (GMR) abnormalities in the spectrum. Read More

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December 2018
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Are parents at a higher risk for secondary traumatic stress?: How interviewing child victims impacts relationships with forensic interviewer's friends and family.

Child Abuse Negl 2018 Dec 12;88:275-287. Epub 2018 Dec 12.

School of Arts & Sciences, University of Houston-Victoria, 3007 N. Ben Wilson, Victoria, TX, 77904, United States. Electronic address:

Background: Forensic interviewers are at a heightened risk for secondary traumatic stress (STS) due to their frequent interactions with victims of child maltreatment (Bonach & Heckert, 2012). To date, however, few studies have examined the negative effects of this work on interviewers' social and emotional well-being.

Objective: The present study seeks to explore the effect of STS on the relationships of forensic interviewers, including those with friends, family, and their respective children. Read More

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December 2018

Improved anti-colorectal carcinomatosis effect of tannic acid co-loaded with oxaliplatin in nanoparticles encapsulated in thermosensitive hydrogel.

Eur J Pharm Sci 2018 Dec 12. Epub 2018 Dec 12.

State Key Laboratory of Biotherapy and Cancer Center and Department of Neurosurgery, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu 610041, PR China. Electronic address:

Tannic acid, a hydrolysable tannin, exists commonly in food plants. Tannic acid has already been shown various anticancer mechanisms such as inhibiting the proliferation, inducing a higher apoptotic rate and slowing down the metastasis of different cancers. Moreover, tannic acid was reported to reduce the side effects caused by chemotherapeutics on patients. Read More

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December 2018

Regarding Manuscript: spontaneous cornual pregnancy after homolateral salpingectomy for an earlier tubal pregnancy: a case report and literature review.

J Minim Invasive Gynecol 2018 Dec 12. Epub 2018 Dec 12.

Department of Obstetrics and Gynecology №1, Marat Ospanov, West Kazakhstan State Medical University (WKSMU), Aktobe, Kazakhstan. Electronic address:

Spontaneous; Cornual; Pregnancy; Salpingectomy; Tubal. Read More

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December 2018
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Clinical signs of meibomian gland dysfunction (MGD) are associated with changes in meibum sphingolipid composition.

Ocul Surf 2018 Dec 12. Epub 2018 Dec 12.

Department of Ophthalmology, Anatomy and Neurobiology, University of Tennessee Health Sciences Center, Hamilton Eye Institute, 930 Madison Avenue, Memphis, TN, 38163, USA. Electronic address:

Purpose: Sphingolipids (SPL) play roles in cell signaling, inflammation, and apoptosis. Changes in SPL composition have been reported in individuals with MGD, but associations between clinical signs of MGD and compositional changes in meibum SPLs have not been examined.

Methods: Forty-three individuals underwent a tear film assessment. Read More

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December 2018
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Novel multifunctional nanocomposite for root caries restorations to inhibit periodontitis-related pathogens.

J Dent 2018 Dec 12. Epub 2018 Dec 12.

Department of Advanced Oral Sciences and Therapeutics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA; Center for Stem Cell Biology & Regenerative Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address:

Objectives: The objectives of this study were to: (1) develop a novel multifunctional composite with nanoparticles of silver (NAg), 2-methacryloyloxyethyl phosphorylcholine (MPC), dimethylaminohexadecyl methacrylate (DMAHDM) and nanoparticles of amorphous calcium phosphate (NACP); and (2) investigate biofilm-inhibition via the multifunctional nanocomposite against three species of periodontal pathogens for the first time.

Methods: The multifunctional nanocomposite was fabricated by incorporating NAg, MPC, DMAHDM and NACP into the resin consisting of pyromellitic glycerol dimethacrylate (PMDGDM) and ethoxylated bisphenol A dimethacrylate (EBPADMA). Three species (Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Fusobacterium nucleatum) were tested for metabolic activity (MTT), live/dead staining, polysaccharide production and colony-forming units (CFU) of biofilms grown on resins. Read More

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December 2018

Inhibition of SIRT1 by microRNA-9, the key point in process of LPS-induced severe inflammation.

Arch Biochem Biophys 2018 Dec 12. Epub 2018 Dec 12.

Department of Burns and Cutaneous Surgery, Xijing Hospital, The Fourth Military Medical University, 127 Changle West Road, Xi'an, Shaanxi, 710032, China. Electronic address:

Severe inflammation may lead to multiple organs dysfunction syndrome, which has a high mortality. MicroRNA is found participated in this process. In this study we developed a lipopolysaccharide-induced inflammation cell model on macrophages and a lipopolysaccharide-induced inflammation mouse model. Read More

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December 2018
3 Reads

Tobacco smoking, alcohol drinking, betel quid chewing, and the risk of head and neck cancer in an East Asian population.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Division of Public Health, Department of Family and Preventive Medicine, and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah.

Background: The smoking prevalence among men in China is high, but the head and neck cancer incidence rates are low. This study's purpose was to investigate the impact of tobacco, betel quid, and alcohol on head and neck cancer risk in East Asia.

Methods: A multicenter case-control study (921 patients with head and neck cancer and 806 controls) in East Asia was conducted. Read More

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December 2018

British Association of Dermatologists guidelines for the management of hidradenitis suppurativa (acne inversa) 2018.

Br J Dermatol 2018 Dec 15. Epub 2018 Dec 15.

British Association of Dermatologists, Willan House, 4 Fitzroy Square, London, W1T 5HQ, U.K.

The overall objective of the guideline is to provide up-to-date, evidence-based recommendations for the management of hidradenitis suppurativa (HS). The document aims to:. offer an appraisal of all relevant literature up to July 2018, focusing on any key developments. Read More

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December 2018

miR-186 inhibits proliferation, migration, and epithelial-mesenchymal transition in breast cancer cells by targeting Twist1.

J Cell Biochem 2018 Dec 14. Epub 2018 Dec 14.

Department of Anesthesiology, Qingdao West Coast New Area Central Hospital, Qingdao, Shandong, China.

Objective: Breast cancer (BC) is the most prevalent malignancy in women worldwide. Our study aimed to investigate the expression and biological effect of miR-186 in BC.

Methods: Expression of miR-186 was determined by quantitative reverse transcription PCR. Read More

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December 2018
2 Reads

Demographic and genetic description of Greenland´s only indigenous Atlantic salmon Salmo salar population.

J Fish Biol 2018 Dec 15. Epub 2018 Dec 15.

Department of Biology, Norwegian University of Science and Technology, Trondheim, Norway.

A survey of the Kapisillit River system was conducted in 2005 and 2012 to study the only indigenous Atlantic salmon Salmo salar population in Greenland. Little is known about its characteristics or its relationship with other S. salar populations across the species range. Read More

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December 2018
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Pulmonary Hypertension During Pregnancy in New York State, 2003-2014.

Matern Child Health J 2018 Dec 14. Epub 2018 Dec 14.

Department of Anesthesiology, Columbia University College of Physicians and Surgeons, 622 West 168th Street, PH5-505, New York, NY, 10032, USA.

Objectives This study examined the prevalence and temporal trends in (a) pulmonary hypertension (PH) during pregnancy and (b) mortality and morbidity during pregnancy with and without PH. Methods This was a retrospective observational study of the 2003-2014 New York State Inpatient Database. PH was categorized as primary or secondary and pregnancy as loss or termination of pregnancy, preterm birth, or term birth. Read More

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December 2018
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Identifying optimal approaches to scale up colorectal cancer screening: an overview of the centers for disease control and prevention (CDC)'s learning laboratory.

Cancer Causes Control 2018 Dec 14. Epub 2018 Dec 14.

Centers for Disease Control and Prevention, Atlanta, GA, USA.

Use of recommended screening tests can reduce new colorectal cancers (CRC) and deaths, but screening uptake is suboptimal in the United States (U.S.). Read More

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December 2018
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2.735 Impact Factor

Therapeutic potentials of the Rho kinase inhibitor Fasudil in experimental autoimmune encephalomyelitis and the related mechanisms.

Metab Brain Dis 2018 Dec 14. Epub 2018 Dec 14.

Institute of Brain Science, Shanxi Datong University, Datong, China.

Multiple sclerosis (MS), Parkinson's disease (PD), Alzheimer's disease (AD), and other neurodegenerative diseases of central nervous system (CNS) disorders are serious human health problems. Rho-kinase (ROCK) is emerging as a potentially important therapeutic target relevant to inflammatory neurodegeneration diseases. This is supported by studies showing the beneficial effects of fasudil, a ROCK inhibitor, in inflammatory neurodegeneration diseases. Read More

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December 2018

Radiologic types of Mycobacterium xenopi pulmonary disease: different patients with similar short-term outcomes.

Eur J Clin Microbiol Infect Dis 2018 Dec 14. Epub 2018 Dec 14.

Division of Respirology, Department of Medicine, University of Toronto, Toronto, ON, Canada.

Mycobacterium xenopi pulmonary disease (Mxe-PD) is common among nontuberculous mycobacterial infections in Europe and Canada. Associations between radiological pattern and clinical features and outcomes are inadequately studied in Mxe-PD. We sought to investigate clinical characteristics and outcomes according to the dominant radiological pattern among patients with Mxe-PD. Read More

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December 2018

Correction to: Platelet number and graft function predict intensive care survival in allogeneic stem cell transplantation patients.

Ann Hematol 2018 Dec 14. Epub 2018 Dec 14.

Department of Bone Marrow Transplantation, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany.

The author name Philipp Wohlfarth was incorrectly spelled as Philipp Wohlfahrth in the original version of this article. Read More

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December 2018