961 results match your criteria Wernicke-Korsakoff Syndrome


Role of Thiamin in Health and Disease.

Nutr Clin Pract 2019 Jan 15. Epub 2019 Jan 15.

Internal Medicine Department, Medical School, São Paulo State University (Unesp), Botucatu, São Paulo, Brazil.

Thiamin is a hydrosoluble vitamin that plays a role in several biological processes, mainly in glucose metabolism. There are several risk factors for developing thiamin deficiency, such as malnutrition, refeeding syndrome, gastrointestinal surgery, and alcoholism. Recently, the role of thiamin in critically ill patients has gained prominence, and the prevalence of thiamin deficiency was found to be increased in patients with severe burns, major surgery, septic shock, end-stage renal disease, and heart failure. Read More

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http://dx.doi.org/10.1002/ncp.10234DOI Listing
January 2019
4 Reads

Wernicke's Encephalopathy due to Non-Alcoholic Gastrointestinal Tract Disease.

Noro Psikiyatr Ars 2018 Dec 25;55(4):307-314. Epub 2018 Apr 25.

Department of Neurology, İstanbul Medical Faculty, University of İstanbul, Turkey.

Introduction: Wernicke's encephalopathy (WE) is an underdiagnosed neuropsychiatric disorder especially in non-alcoholic groups that causes morbidity-mortality if diagnosis is delayed. Korsakoff syndrome is a chronic consequence of this condition characterized by persistent memory impairment. In this study we present a series of non-alcoholic patients with WE. Read More

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http://dx.doi.org/10.29399/npa.23010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300840PMC
December 2018
14 Reads

Identification and Evaluation of Neuropsychological Tools Used in the Assessment of Alcohol-Related Cognitive Impairment: A Systematic Review.

Front Psychol 2018 18;9:2618. Epub 2018 Dec 18.

Addictions Research Group, University of South Wales, School of Psychology & Therapeutic Studies, Pontypridd, United Kingdom.

Neuropsychological assessment is central to identifying and determining the extent of Alcohol-Related Cognitive Impairment (ARCI). The present systematic review aimed to synthesize and discuss the evidence appraising the neuropsychological tests used to assess ARCI in order to support clinicians and researchers in selecting appropriate tests for use with this population. We searched for studies investigating the psychometric, diagnostic and practical values of tools used in the screening, diagnosis, and assessment of Korsakoff's Syndrome (KS), Alcohol-Related Dementia (ARD), and those with a specific diagnosis of Alcohol-Related Brain Damage (ARBD). Read More

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http://dx.doi.org/10.3389/fpsyg.2018.02618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305333PMC
December 2018
2 Reads

Vitamin Deficiency and Systemic Failure: The Case For Greater Focus On Wernicke-Korsakoff Syndrome

Ir Med J 2018 Dec 6;111(10):848. Epub 2018 Dec 6.

William Stokes Postgraduate Centre, St. James’s Hospital, Dublin 8.

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December 2018
1 Read

[A Reversible Case of Korsakoff Syndrome in an Alcohol Dependent Patient].

Psychiatr Prax 2018 Dec 12. Epub 2018 Dec 12.

LVR-Klinikum Düsseldorf, Kliniken der Heinrich-Heine-Universität, Medizinische Fakultät Düsseldorf.

Alcohol dependent patients represent a high-risk group for vitamin deficiency, which could lead to variable cognitive dysfunctions and, as an extreme example, to an amnestic-confabulatory syndrome. In this case report, we report about an alcohol dependent 58-year-old patient without focal neurological symptoms with an amnestic-confabulatory syndrome. After substitution of thiamine, vitamin B12 and folic acid, cognitive symptoms completely vanish within a 22-month period of observation. Read More

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http://dx.doi.org/10.1055/a-0807-4290DOI Listing
December 2018
7 Reads

Executive Dysfunction in Patients With Korsakoff's Syndrome: A Theory-Driven Approach.

Alcohol Alcohol 2019 Jan;54(1):23-29

Donders Institute for Brain, Cognition and Behaviour, Radboud University, Montessorilaan 3, Nijmegen, The Netherlands.

Aims: In addition to amnesia, executive deficits are prominent in Korsakoff's syndrome (KS), yet poorly studied. This study investigates the degree of executive dysfunction in patients with KS for the three main executive subcomponents shifting, updating and inhibition using novel, theory-driven paradigms.

Short Summary: Compared to healthy controls, patients with KS show impairments on the executive subcomponents shifting and updating, but not on inhibition. Read More

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http://dx.doi.org/10.1093/alcalc/agy078DOI Listing
January 2019
10 Reads

[Neurological pathology associated with vitamin B group deficiency: thiamine, folate and cobalamin].

Nutr Hosp 2018 Sep 7;35(Spec No6):54-59. Epub 2018 Sep 7.

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The "fragility" of the nervous system, especially concerning to its nutrition and metabolism, explains why vitamin deficits are an important cause of neurological pathology. Some deficiency diseases, which can be very severe and irreversible, are still present in our environment; diagnosis, which must be early so as not to delay treatment, can be difficult if we do not have them in mind. In this review we address the most relevant neurological diseases associated with thiamine, folate and cobalamin deficiency, and we focus especially combined subacute degeneration and Wernicke-Korsakoff syndrome. Read More

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http://dx.doi.org/10.20960/nh.2289DOI Listing
September 2018
2 Reads

Review of thiamine deficiency disorders: Wernicke encephalopathy and Korsakoff psychosis.

J Basic Clin Physiol Pharmacol 2018 Oct 2. Epub 2018 Oct 2.

Clinical Research Unit, Children's Hospital Research Institute of Manitoba, Winnipeg, Canada.

Wernicke encephalopathy (WE) and Korsakoff psychosis (KP), together termed Wernicke-Korsakoff syndrome (WKS), are distinct yet overlapping neuropsychiatric disorders associated with thiamine deficiency. Thiamine pyrophosphate, the biologically active form of thiamine, is essential for multiple biochemical pathways involved in carbohydrate utilization. Both genetic susceptibilities and acquired deficiencies as a result of alcoholic and non-alcoholic factors are associated with thiamine deficiency or its impaired utilization. Read More

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http://www.degruyter.com/view/j/jbcpp.ahead-of-print/jbcpp-2
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http://dx.doi.org/10.1515/jbcpp-2018-0075DOI Listing
October 2018
9 Reads

Chunking to improve verbal forward spans in Korsakoff's syndrome.

Appl Neuropsychol Adult 2018 Sep 5:1-8. Epub 2018 Sep 5.

h CNRS CHU Lille, et UMR 9193 - SCALab - Sciences Cognitives Sciences Affectives , Univ. Lille , Lille , France.

Chunking is a mnemonic strategy that involves organizing information into appropriate units. Our article examined the use of this strategy on forward and backward span performance in Korsakoff's syndrome. Fifteen patients with Korsakoff's syndrome and 17 age-and-education matched healthy controls participated to the study. Read More

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http://dx.doi.org/10.1080/23279095.2018.1499023DOI Listing
September 2018
27 Reads

Social and emotional loneliness in Korsakoff's syndrome.

Cogn Neuropsychiatry 2018 09 10;23(5):307-320. Epub 2018 Aug 10.

a Experimental Psychology , Helmholtz Institute, Utrecht University , Utrecht , Netherlands.

Introduction: Loneliness is the subjective negative evaluation of social participation and isolation. Emotional loneliness reflects the absence of close relationships, and social loneliness the absence of a social network. Although loneliness is a growing problem in modern society, studies about loneliness in patients with Korsakoff's syndrome (KS) in need of chronic care are currently missing. Read More

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http://dx.doi.org/10.1080/13546805.2018.1505607DOI Listing
September 2018
4 Reads

Wernicke-Korsakoff Syndrome in End-Stage Renal Disease: A Case Report.

Ther Apher Dial 2018 12 15;22(6):676-679. Epub 2018 Jul 15.

Nephrology and Dialysis Unit, "Pugliese-Ciaccio" Hospital of Catanzaro, Catanzaro, Italy.

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http://dx.doi.org/10.1111/1744-9987.12715DOI Listing
December 2018
18 Reads
1.532 Impact Factor

Is physical rehabilitation effective for Wernicke-Korsakoff syndrome? A case report.

Int J Rehabil Res 2018 Dec;41(4):373-376

Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Ankara University, Ankara, Turkey.

Wernicke-Korsakoff syndrome is a type of brain disorder caused by the lack of thiamine, most commonly because of chronic alcohol misuse. It consists of two separate conditions including Wernicke's encephalopathy and Korsakoff syndrome. Various levels of cognitive impairments are associated with the severity of the syndrome. Read More

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http://Insights.ovid.com/crossref?an=00004356-900000000-9948
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http://dx.doi.org/10.1097/MRR.0000000000000303DOI Listing
December 2018
10 Reads

Tell about yourself to improve your autobiographical memory: A study of Korsakoff's syndrome.

Psychiatry Res 2018 10 30;268:37-41. Epub 2018 Jun 30.

Univ. Lille, CNRS, CHU Lille, UMR 9193 - SCALab, Sciences Cognitives et Sciences Affectives, Lille F-59000, France.

Korsakoff's syndrome (KS) has been associated with a difficulty to retrieve specific autobiographical memories. We investigated whether this difficulty can be alleviated after the retrieval of statements describing self-images. KS patients and control participants were recruited and asked to retrieve autobiographical memories after providing statements to the question "Who am I?" and after a control condition consisting of verbal fluency. Read More

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http://dx.doi.org/10.1016/j.psychres.2018.06.064DOI Listing
October 2018
5 Reads

Preventing Wernicke's encephalopathy in anorexia nervosa: A systematic review.

Psychiatry Clin Neurosci 2018 Oct 31;72(10):774-779. Epub 2018 Jul 31.

Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, The Netherlands.

Anorexia nervosa (AN) is a common eating disorder that affects 2.9 million people worldwide. Not eating a balanced diet or fasting can cause neurological complications after severe vitamin B1 malnourishment, although the precise signs and symptoms of Wernicke's encephalopathy (WE) are not clear. Read More

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http://dx.doi.org/10.1111/pcn.12735DOI Listing
October 2018
12 Reads

The effect of errorless learning on psychotic and affective symptoms, as well as aggression and apathy in patients with Korsakoff's syndrome in long-term care facilities.

Int Psychogeriatr 2019 Jan 20;31(1):39-47. Epub 2018 Jun 20.

Centre of Excellence for Korsakoff and Alcohol-Related Cognitive Disorders,Vincent van Gogh Institute for Psychiatry,Venray,the Netherlands.

ABSTRACTObjectives:Errorless learning is a promising rehabilitation principle for learning tasks in patients with amnesia, including patients with Korsakoff's syndrome. Errorless learning might possibly also contribute to decreases in behavioral and psychiatric problems, as patients in long-term care facilities become more independent after training. The aim of this study was to examine the effects of errorless learning on potential changes in psychotic and affective symptoms, aggression and apathy, in contrast with a control group who received care as usual. Read More

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http://dx.doi.org/10.1017/S1041610218000492DOI Listing
January 2019
6 Reads

Korsakoff Syndrome in Non-alcoholic Psychiatric Patients. Variable Cognitive Presentation and Impaired Frontotemporal Connectivity.

Front Psychiatry 2018 31;9:204. Epub 2018 May 31.

Department of Psychiatry, University of Turku, Turku, Finland.

Non-alcoholic Wernicke's encephalopathy and Korsakoff syndrome are greatly underdiagnosed. There are very few reported cases of neuropsychologically documented non-alcoholic Korsakoff syndrome, and diffusion tensor imaging (DTI) data are scarce. We report clinical characteristics and neuropsychological as well as radiological findings from three psychiatric patients (one woman and two men) with a history of probable undiagnosed non-alcoholic Wernicke's encephalopathy and subsequent chronic memory problems. Read More

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http://dx.doi.org/10.3389/fpsyt.2018.00204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992887PMC
May 2018
12 Reads

Beyond Thiamine: Treatment for Cognitive Impairment in Korsakoff's Syndrome.

Psychosomatics 2018 Jul - Aug;59(4):311-317. Epub 2018 Mar 27.

Durham VA Medical Center, Durham, NC.

Background: Wernicke's encephalopathy is a condition whose treatment many consultation-liaison psychiatrists know quite well. Less clear, however, is the treatment of its dementia disorder descendent, the Korsakoff's syndrome (KS).

Objective: This article seeks to review treatment options and provide recommendations for consultation-liaison psychiatrists treating cognitive impairment in KS. Read More

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http://dx.doi.org/10.1016/j.psym.2018.03.011DOI Listing
March 2018
5 Reads

What can go wrong in hyperemesis gravidarum: Wernicke-Korsakoff syndrome in Bulawayo, Zimbabwe.

Clin Case Rep 2018 May 8;6(5):802-804. Epub 2018 Mar 8.

Department of Medicine United Bulawayo Hospitals 2 St Lukes Road, Ascot Bulawayo Zimbabwe.

We report two cases of Wernicke-Korsakoff syndrome (WKS) secondary to hyperemesis gravidarum. Oral thiamine was administered (intravenous unavailable locally). However, both the patient's condition improved in the first 48 h and progressively over a month. Read More

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http://dx.doi.org/10.1002/ccr3.1462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930197PMC
May 2018
3 Reads

Thiamine and Alcohol for Brain Pathology: Super-imposing or Different Causative Factors for Brain Damage?

Curr Drug Abuse Rev 2017 ;10(1):44-51

Italian Liver Foundation, Centro Studi Fegato, SS14, Km 163.5, Trieste, 34149, Italy.

Background: Drinking more than the recommended limits is a worldwide emerging problem, difficult to circumscribe, and alcohol-related brain damages are an under-recognized health problem. Alcohol-cognitive disruption can be considered as transient and recoverable if the alcohol consumption is limited and occasional; if not, it can progress to the so-called Alcohol-Related Dementia (ARD), or to the Wernicke encephalopathy, or it can even induce the Korsakoff syndrome, an irreversible and long-lasting medical condition. ARD still remains poorly diagnosed and addressed, despite having increased research interest being a frustrating condition, a relatively non-progressive, or even partially reversible condition in abstinent ex-drinkers. Read More

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http://dx.doi.org/10.2174/1874473711666180402142012DOI Listing
October 2018
34 Reads

Severe neurological complication following adjustable gastric banding.

G Chir 2018 Mar-Apr;39(2):92-96

Aim: In the last years with the increase of bariatric surgery, first of all as a result of new indications, a rise in the incidence of nutrient-related complications has been observed. Currently little is known about the impact of post-bariatric malnutrition and neurological complications. Wernicke's encephalopathy is a severe neurological syndrome which occurs as a result of thiamine deficiency. Read More

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April 2018
2 Reads

Forgetting the new locations of one's keys: spatial-memory interference in Korsakoff's amnesia.

Exp Brain Res 2018 07 21;236(7):1861-1868. Epub 2018 Apr 21.

Centre of Excellence for Korsakoff and Alcohol-Related Cognitive Disorders, Vincent van Gogh Institute for Psychiatry, Venray, The Netherlands.

The present study focused on interference in a group of patients with amnesia due to Korsakoff's syndrome (KS) within the domain of spatial memory. An object-location memory task was used in which participants first learned an array of objects on a computer screen, followed by a reconstruction of the object positions. Next a trial was given in which the same objects were presented only now in different locations. Read More

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http://dx.doi.org/10.1007/s00221-018-5266-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010480PMC
July 2018
6 Reads

Impaired affective prosody decoding in severe alcohol use disorder and Korsakoff syndrome.

Psychiatry Res 2018 06 3;264:404-406. Epub 2018 Apr 3.

Laboratory for Experimental Psychopathology, Psychological Science Research Institute, Faculté de Psychologie, Université catholique de Louvain, 10 Place C. Mercier, B-1348 Louvain-la-Neuve, Belgium. Electronic address:

Recognizing others' emotions is a fundamental social skill, widely impaired in psychiatric populations. These emotional dysfunctions are involved in the development and maintenance of alcohol-related disorders, but their differential intensity across emotions and their modifications during disease evolution remain underexplored. Affective prosody decoding was assessed through a vocalization task using six emotions, among 17 patients with severe alcohol use disorder, 16 Korsakoff syndrome patients (diagnosed following DSM-V criteria) and 19 controls. Read More

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http://dx.doi.org/10.1016/j.psychres.2018.04.001DOI Listing
June 2018
7 Reads

[The prevention of Korsakoff's syndrome by offering involuntary care?]

Tijdschr Psychiatr 2018;60(4):250-257

Background: The new draft Law on care and coercion focuses on the care of people with a psychogeriatric disorder or intellectual disability. Perhaps this law can be applied to people suffering from chronic alcoholism, associated with an increased risk of Korsakoff's syndrome.

Aim: To explore whether the new draft law on care and coercion can be applied to people suffering from chronic alcoholism who still live at home. Read More

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August 2018
13 Reads

Non-alcoholic Wernicke-Korsakoff syndrome heralding non-Hodgkin lymphoma progression.

Neurol Sci 2018 08 26;39(8):1493-1495. Epub 2018 Mar 26.

Neurology Unit, Ospedale del Mare, Via Enrico Russo, 80147, Naples, Italy.

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http://dx.doi.org/10.1007/s10072-018-3313-6DOI Listing
August 2018
5 Reads

Imbalance between cognitive systems in alcohol-dependence and Korsakoff syndrome: An exploration using the Alcohol Flanker Task.

J Clin Exp Neuropsychol 2018 Oct 6;40(8):820-831. Epub 2018 Mar 6.

a Laboratory for Experimental Psychopathology, Psychological Sciences Research Institute , Université catholique de Louvain , Louvain-la-Neuve , Belgium.

Background: Alcohol-dependent individuals (ALC) simultaneously present decreased inhibitory control and increased attention towards alcohol-related cues. The dual-process models have proposed that these symptoms reflect an imbalance between prefrontal/reflective and limbic/automatic systems, respectively leading to cognitive dysfunctions in executive processes and to alcohol-related bias. However, most previous research has focused on a separate exploration of these systems among ALC, and the direct measure of their interactions remains to be conducted. Read More

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http://dx.doi.org/10.1080/13803395.2018.1438371DOI Listing
October 2018
9 Reads

Clinical Characteristics and Outcomes Associated With High-Dose Intravenous Thiamine Administration in Patients With Encephalopathy.

Psychosomatics 2018 Jul - Aug;59(4):379-387. Epub 2018 Jan 11.

Department of Psychiatry, University of North Carolina, Chapel Hill, NC; Department of Medicine, University of North Carolina, Chapel Hill, NC.

Background: Wernicke encephalopathy is a common neuropsychiatric syndrome due to thiamine deficiency. There is no consensus regarding thiamine dosing when Wernicke encephalopathy is suspected. A longstanding dosing strategy for Wernicke encephalopathy is 100mg daily, yet updated clinical guidelines suggest using high-dose intravenous (HDIV) thiamine. Read More

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http://dx.doi.org/10.1016/j.psym.2018.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015524PMC
January 2018
14 Reads

Preserved re-experience of discrete emotions: Amnesia and executive function.

J Neuropsychol 2018 Feb 7. Epub 2018 Feb 7.

School of Psychology, Bangor, Gwynedd, UK.

Amnesic patients can re-experience emotions elicited by forgotten events, suggesting that brain systems for episodic and emotional memory are independent. However, the range of such emotional memories remains under-investigated (most studies employing just positive-negative emotion dyads), and executive function may also play a role in the re-experience of emotions. This is the first investigation of the intensity of the emotional re-experience of a range of discrete emotions (anger, fear, sadness, and happiness) for a group of amnesic patients. Read More

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http://dx.doi.org/10.1111/jnp.12147DOI Listing
February 2018
9 Reads

Diagnosis makes a difference: Perceptions of older persons with dementia symptoms.

Exp Aging Res 2018 Mar-Apr;44(2):148-161. Epub 2018 Feb 5.

c Department of Psychology , The University of Wisconsin Oshkosh , Oshkosh , WI.

Background/Study Context: Employing the stereotype content model and terror management theory, we examined whether stereotypes and feelings about persons with dementia vary depending on the type of dementia diagnosis and purported causes of the dementia.

Methods: Participants were randomly assigned to read one of four vignettes that depicted a man who consulted his doctor because of memory problems. All vignettes described the same symptoms and diagnostic tests, but each of four groups read a different result: all tests normal (Normal); Alzheimer's disease (AD); Wernicke-Korsakoff Syndrome (WKS) associated with alcohol abuse; and chronic traumatic encephalopathy (CTE) associated with head injuries from playing football in high school and college. Read More

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http://dx.doi.org/10.1080/0361073X.2017.1422475DOI Listing
December 2018
10 Reads

Wernicke-Korsakoff syndrome as a rare phenotype of sporadic Creutzfeldt-Jakob disease.

Prion 2018 03 9;12(2):143-146. Epub 2018 Feb 9.

a Department of Neurology , Medical University of Lublin , Lublin , Poland.

We reported the case of a patient with Wernicke-Korsakoff syndrome (WKs) as an early clinical manifestation of sporadic Creutzfeld-Jakob disease (sCJD). The 66-year-old female complained of dizziness and imbalance which mostly occurred while walking. A neurological examination revealed a triad of symptoms characteristic for WKs such as gaze paresis, ataxia of limbs and trunk as well as memory disturbances with confabulations. Read More

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https://www.tandfonline.com/doi/full/10.1080/19336896.2018.1
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http://dx.doi.org/10.1080/19336896.2018.1433988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016515PMC
March 2018
10 Reads

[Wernicke-Korsakoff syndrome secondary to cytomegalovirus encephalitis: A case report].

Biomedica 2017 Dec 1;37(4):444-451. Epub 2017 Dec 1.

Departamento de Infectología, Hospital Universitario de Bucaramanga "Los Comuneros", Bucaramanga, Colombia.

Cytomegalovirus (CMV) is one of the opportunistic microorganisms with the highest prevalence in immunocompromised patients. Reactivation has decreased after the introduction of highly active antiretroviral therapy (HAART). Encephalitis has been reported in the coinfection as one of the most frequent presentations. Read More

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http://dx.doi.org/10.7705/biomedica.v37i4.3451DOI Listing
December 2017
28 Reads

Intellectual Profiles in KBG-Syndrome: A Wechsler Based Case-Control Study.

Front Behav Neurosci 2017 19;11:248. Epub 2017 Dec 19.

Centre of Excellence for Neuropsychiatry, Vincent van Gogh Institute for Psychiatry, Venray, Netherlands.

KBG syndrome is a neurodevelopmental disorder (NDD) caused by loss-of-function of the gene. The core phenotype comprises developmental delay (DD)/ intellectual disability (ID) and several specific facial dysmorphisms. In addition, both ADHD- and ASD-related symptoms have been mentioned. Read More

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http://dx.doi.org/10.3389/fnbeh.2017.00248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742227PMC
December 2017
6 Reads

The implicit revolution: Reconceiving the relation between conscious and unconscious.

Am Psychol 2017 Dec;72(9):861-871

Department of Psychology, Harvard University.

In the 1970s, memory researchers converged on interesting phenomena observed in Korsakoff-syndrome amnesic patients. These patients' performances on difficult tasks were reliably improved by practice sessions from which they could recall nothing. Related findings of indirect memory effects in college students triggered wide attention to phenomena that, in 1985, were first identified as implicit memory. Read More

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http://dx.doi.org/10.1037/amp0000238DOI Listing
December 2017
7 Reads

Effects of drinking on late-life brain and cognition.

Evid Based Ment Health 2018 Feb 22;21(1):12-15. Epub 2017 Dec 22.

Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.

Alcohol consumption is common in Western countries and has been increasing in older adults. Latest figures from Great Britain suggest 75% of those over 65 years drink, an increase from 71% 10 years ago. Chronic heavy intake is a well-established cause of brain atrophy and dementia, with a recent long-term prospective study from the USA reporting a doubling of the odds of later severe memory impairment in those with a history of an alcohol use disorder. Read More

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http://dx.doi.org/10.1136/eb-2017-102820DOI Listing
February 2018
7 Reads

Korsakoff's syndrome: a critical review.

Neuropsychiatr Dis Treat 2017 27;13:2875-2890. Epub 2017 Nov 27.

Centre of Excellence for Korsakoff and Alcohol-Related Cognitive Disorders, Vincent van Gogh Institute for Psychiatry, Venray.

In this review, we present a survey on Korsakoff's syndrome (KS), a residual syndrome in patients who suffered from a Wernicke encephalopathy (WE) that is predominantly characterized by global amnesia, and in more severe cases also by cognitive and behavioral dysfunction. We describe the history of KS and its definition, its epidemiology, and the lack of consensus criteria for its diagnosis. The cognitive and behavioral symptoms of KS, which include anterograde and retrograde amnesia, executive dysfunction, confabulation, apathy, as well as affective and social-cognitive impairments, are discussed. Read More

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http://dx.doi.org/10.2147/NDT.S130078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708199PMC
November 2017
14 Reads

The effect of errorless learning on quality of life in patients with Korsakoff's syndrome.

Neuropsychiatr Dis Treat 2017 27;13:2867-2873. Epub 2017 Nov 27.

Center of Excellence for Korsakoff and Alcohol-Related Cognitive Disorders, Vincent van Gogh Institute for Psychiatry, Venray, the Netherlands.

Background: Errorless learning (EL) is a promising rehabilitation principle for (re)learning instrumental activities in patients with amnesia, including patients with Korsakoff's syndrome (KS). Successfully (re)learning tasks might improve the sense of competence and independence, and subsequently the quality of life. Quality of life in patients with KS has received limited attention, and no studies have been conducted to experimentally examine the effect of EL on quality of life in patients in this patient group. Read More

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http://dx.doi.org/10.2147/NDT.S140950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708189PMC
November 2017
9 Reads

Wet Beriberi Associated with Hikikomori Syndrome.

J Gen Intern Med 2018 Mar 29;33(3):384-387. Epub 2017 Nov 29.

Department of Critical Care Medicine, Tokyo Bay Urayasu Ichikawa Medical Center, Urayasu-city, Japan.

Wet beriberi, characterized by high cardiac output with predominantly right-sided heart failure and lactic acidosis, is a disease caused by thiamine deficiency, and is rarely seen in modern society. However, patients with social withdrawal syndrome, also known as hikikomori syndrome, may be a new population at risk of thiamine deficiency. Hikikomori syndrome, first recognized in Japan, is becoming a worldwide issue. Read More

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http://dx.doi.org/10.1007/s11606-017-4208-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834955PMC
March 2018
12 Reads

Impairment of Thiamine Transport at the GUT-BBB-AXIS Contributes to Wernicke's Encephalopathy.

Mol Neurobiol 2018 Jul 11;55(7):5937-5950. Epub 2017 Nov 11.

Laboratory of Neurovascular Inflammation and Neurodegeneration, Department of Biomedical Engineering, Center for Injury Bio Mechanics, Materials and Medicine, New Jersey Institute of Technology, 111 Lock Street, Newark, NJ, 07102, USA.

Wernicke's encephalopathy, a common neurological disease, is caused by thiamine (vitamin B1) deficiency. Neuropathy resulting from thiamine deficiency is a hallmark of Wernicke-Korsakoff syndrome in chronic alcohol users. The underlying mechanisms of this deficiency and progression of neuropathy remain to be understood. Read More

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http://dx.doi.org/10.1007/s12035-017-0811-0DOI Listing
July 2018
13 Reads

Wernicke-Korsakoff syndrome complicated by subacute beriberi neuropathy in an alcoholic patient.

Clin Neurol Neurosurg 2018 01 8;164:1-4. Epub 2017 Nov 8.

Department of Experimental Biomedicine and Clinical Neurosciences (BioNeC), University of Palermo, Italy. Electronic address:

Thiamine (vitamin B1) deficiency is a common condition in alcohol abusers, which can lead to damage of both the peripheral and the central nervous systems. Here we describe the case of an alcoholic patient who presented with acute onset of ataxia, severe weakness of the four limbs, and hypoesthesia and dysesthesia of the distal portion of the upper and lower extremities. The clinical picture also included mental confusion and amnesia. Read More

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http://dx.doi.org/10.1016/j.clineuro.2017.11.006DOI Listing
January 2018
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Alcool et troubles cognitifs chez la personne âgée.

Praxis (Bern 1994) 2017;106(22):1221-1223

1 Service d'alcoologie, Département universitaire de médecine et santé communautaires, Centre hospitalier universitaire vaudois (CHUV), Lausanne.

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https://econtent.hogrefe.com/doi/10.1024/1661-8157/a002805
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http://dx.doi.org/10.1024/1661-8157/a002805DOI Listing
December 2017
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A three-decade repeated cross-sectional survey on mental health of the Chinese Jino minority.

Aust N Z J Psychiatry 2017 Nov 1;51(11):1134-1141. Epub 2016 Dec 1.

2 Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, China.

Objective: As there is growing evidence outlining varying degrees of social, economic and cultural changes among minority groups in China, there was a need to undertake research to determine whether modernization and urbanization of China has had an impact on the mental health of individuals from minority groups. In 1979, the Jino ethnic minority group was the last minority group to be designated a minority by the Chinese Central Government. As a direct result of the Chinese Government intervention, the Jino society began transitioning from a traditional rural lifestyle existence to that of a more modern urban lifestyle. Read More

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http://dx.doi.org/10.1177/0004867416682599DOI Listing
November 2017
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Neuropsychiatric Symptoms in People With Korsakoff Syndrome and Other Alcohol-Related Cognitive Disorders Living in Specialized Long-Term Care Facilities: Prevalence, Severity, and Associated Caregiver Distress.

J Am Med Dir Assoc 2018 Mar 1;19(3):240-247. Epub 2017 Nov 1.

Department of General Practice and Elderly Care Medicine, Amsterdam Public Health research institute, VU University Medical Center, Amsterdam, the Netherlands.

Objectives: Caring for people with Korsakoff syndrome (KS) residing in specialized long-term care facilities (LTCFs) can be distressing because of challenging neuropsychiatric symptoms (NPS). However, good-quality studies on NPS in this under-researched population are lacking. This study examined the prevalence and severity of NPS in people with KS living in specialized LTCFs and the associated caregiver distress. Read More

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http://dx.doi.org/10.1016/j.jamda.2017.09.013DOI Listing
March 2018
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Modification of Automatic Alcohol-Approach Tendencies in Alcohol-Dependent Patients with Mild or Major Neurocognitive Disorder.

Alcohol Clin Exp Res 2018 Jan 24;42(1):153-161. Epub 2017 Nov 24.

Centre of Excellence for Neuropsychiatry, Vincent van Gogh Institute for Psychiatry, Venray, the Netherlands.

Background: To examine the applicability of an alcohol-avoidance training procedure in patients with alcohol dependence and alcohol-induced neurocognitive disorders (NDs), we trained 2 groups that differed in the degree of cognitive impairment: One group fulfilled the DSM-5 criteria for alcohol-induced mild ND, and 1 group was diagnosed with Korsakoff's syndrome (KS) (alcohol-induced major ND, confabulatory/amnesic subtype; DSM-5). The intervention is assumed to match the preserved cognitive capacity for implicit learning in both groups.

Methods: Fifty-one inpatients with a mild ND and 54 inpatients with KS were trained. Read More

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http://dx.doi.org/10.1111/acer.13529DOI Listing
January 2018
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Alcohol's Effects on the Brain: Neuroimaging Results in Humans and Animal Models.

Alcohol Res 2017 ;38(2):183-206

Natalie M. Zahr, Ph.D., is a Research Scientist in the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California; and Program Director of Translational Imaging, Neuroscience Program, SRI International, Menlo Park, California. Adolf Pfefferbaum, M.D., is Professor of Psychiatry and Behavioral Sciences at Stanford University School of Medicine, Stanford, California; and Distinguished Scientist and Center Director of the Neuroscience Program, SRI International, Menlo Park, California.

Brain imaging technology has allowed researchers to conduct rigorous studies of the dynamic course of alcoholism through periods of drinking, sobriety, and relapse and to gain insights into the effects of chronic alcoholism on the human brain. Magnetic resonance imaging (MRI) studies have distinguished alcohol-related brain effects that are permanent from those that are reversible with abstinence. In support of postmortem neuropathological studies showing degeneration of white matter, MRI studies have shown a specific vulnerability of white matter to chronic alcohol exposure. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513685PMC
May 2018
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Errorless (re)learning of everyday activities in patients with Korsakoff's syndrome: A feasibility study.

Neuropsychol Rehabil 2017 Oct 2:1-15. Epub 2017 Oct 2.

a Centre of Excellence for Korsakoff and Alcohol-Related Cognitive Disorders , Vincent van Gogh Institute for Psychiatry , Venray , The Netherlands.

Errorless learning has proven to be an effective method for (re)learning tasks in several patient groups with amnesia. However, so far only a handful of studies have examined the effects of errorless learning in patients with Korsakoff's syndrome. The aims of this feasibility study were to (a) examine the effects of errorless learning training on (re)learning tasks in a patient with Korsakoff's syndrome, (b) examine the effects of the nature of the training on the execution of the tasks, and (c) examine characteristics that may mediate learning outcome. Read More

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http://dx.doi.org/10.1080/09602011.2017.1379419DOI Listing
October 2017
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Phenomenological characteristics of autobiographical memory in Korsakoff's syndrome.

Conscious Cogn 2017 10 6;55:188-196. Epub 2017 Sep 6.

Univ. Lille, CNRS, CHU Lille, UMR 9193 - SCALab - Sciences Cognitives et Sciences Affectives, F-59000 Lille, France.

A body of research suggests compromise of autobiographical memory in Korsakoff's syndrome (KS). The present paper extends this literature by investigating the subjective experience of autobiographical recall in the syndrome. Patients with KS and controls were asked to retrieve autobiographical memories. Read More

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http://dx.doi.org/10.1016/j.concog.2017.08.011DOI Listing
October 2017
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Crossmodal processing of emotions in alcohol-dependence and Korsakoff syndrome.

Cogn Neuropsychiatry 2017 Sep 8;22(5):436-451. Epub 2017 Sep 8.

a Laboratory for Experimental Psychopathology , Psychological Sciences Research Institute, Université catholique de Louvain , Louvain-la-Neuve , Belgium.

Introduction: Decoding emotional information from faces and voices is crucial for efficient interpersonal communication. Emotional decoding deficits have been found in alcohol-dependence (ALC), particularly in crossmodal situations (with simultaneous stimulations from different modalities), but are still underexplored in Korsakoff syndrome (KS). The aim of this study is to determine whether the continuity hypothesis, postulating a gradual worsening of cognitive and brain impairments from ALC to KS, is valid for emotional crossmodal processing. Read More

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http://dx.doi.org/10.1080/13546805.2017.1373639DOI Listing
September 2017
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Split-brain phenomena in anterior communicating artery aneurysm rupture: A case report.

Psych J 2017 Jun;6(2):120-136

Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.

In 1976, a patient with an anterior communicating artery aneurysm (ACoAA) rupture (diagnosed on angiography) and sub-arachnoid hemorrhage (SAH) underwent serial neuropsychological testing revealing a classical anterior cerebral artery (ACA) spasm picture with severe anterograde amnesia of Korsakoff's type and dysexecutive syndrome. In addition, the patient demonstrated impaired hemispheric interaction with alien hand syndrome, dyscopia-dysgraphia, complete left ear neglect, and other, more complex, split-brain phenomena. He was evaluated by A. Read More

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http://dx.doi.org/10.1002/pchj.145DOI Listing
June 2017
12 Reads