1,068 results match your criteria Wernicke-Korsakoff Syndrome

Alcohol-Related Dementia: Rethink How Much You Drink.

Sr Care Pharm 2021 Jul;36(7):324-330

People have consumed alcohol for centuries. Most clinicians who work with people who have dementia acknowledge that alcohol may cause or exacerbate dementia's symptoms. Alcohol-related dementia (ARD) has been recognized since the 1960s, but clinicians rarely use this diagnosis. Read More

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Behavioral, Emotional and Social Apathy in Alcohol-Related Cognitive Disorders.

J Clin Med 2021 May 31;10(11). Epub 2021 May 31.

Centre of Excellence for Korsakoff and Alcohol-Related Cognitive Disorders, Vincent van Gogh Institute for Psychiatry, 5803 DN Venray, The Netherlands.

Apathy is a fundamental neuropsychiatric symptom of Korsakoff's syndrome (KS) and has also been reported in patients with alcohol use disorder with no (AUD) or less severe cognitive impairments (ARCI). However, research on the nature of apathy is limited in these groups. Aim of this study was to examine the multidimensional nature of apathy in patients with KS, ARCI and AUD. Read More

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Confabulations in post-acute and chronic alcoholic Korsakoff's syndrome: a cross-sectional study conducted in two centres.

Int J Psychiatry Clin Pract 2021 May 31:1-5. Epub 2021 May 31.

Center of Excellence for Korsakoff and Alcohol-Related Cognitive Disorders, Vincent van Gogh Institute for Psychiatry, Venray, The Netherlands.

Introduction: Confabulations refer to the emergence of memories of experiences and events that are incorrect in place and time, or never took place. In alcoholic Korsakoff's syndrome, confabulations have been frequently reported, but seldomly been investigated. Traditional reports on confabulations state that confabulations in KS mainly occur in the post-acute phase of the illness. Read More

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Wernicke-Korsakoff syndrome despite no alcohol abuse: A summary of systematic reports.

J Neurol Sci 2021 Jul 7;426:117482. Epub 2021 May 7.

Experimental Psychology, Helmholtz Institute, Utrecht University, the Netherlands; Slingedael Korsakoff Center, Lelie Care Group, Rotterdam, the Netherlands.

Background: Wernicke-Korsakoff syndrome (WKS) is a neurological disorder typically found in alcohol use disorder. The fact that it also occurs in nonalcoholic patients is less well known and often ignored. For the first time, this review offers a systematic investigation of the frequency and associated features of nonalcoholic WKS in the published literature. Read More

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Wernicke Encephalopathy in an Elderly Patient Due to Chronic Malnutrition From an Atypical Diet.

Cureus 2021 Mar 31;13(3):e14210. Epub 2021 Mar 31.

Psychiatry, Lewis Gale Medical Center, Salem, USA.

Wernicke encephalopathy has traditionally been associated with chronic alcohol abuse leading to thiamine deficiency. Clinical symptoms include mentation change, gait ataxia, and oculomotor abnormalities. However, it is often an underdiagnosed condition in patients suffering from chronic malnutrition, especially in the West. Read More

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A randomized double-blind placebo-controlled trial of intravenous thiamine for prevention of delirium following allogeneic hematopoietic stem cell transplantation.

J Psychosom Res 2021 Jul 27;146:110503. Epub 2021 Apr 27.

Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Medicine, Division of Hematology/Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Objective: To determine if high dose intravenous (IV) thiamine can prevent delirium during hospitalization following allogeneic HSCT. Secondarily, we evaluated the effects of high dose IV thiamine on thiamine levels and explored risk factors for delirium.

Methods: Randomized, double-blind, placebo-controlled trial in patients undergoing allogeneic HSCT at a U. Read More

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Polyneuropathy and Korsakoff syndrome complicating sleeve gastrectomy.

Obes Res Clin Pract 2021 May-Jun;15(3):293-296. Epub 2021 Apr 30.

Department of Internal Medicine, King Saud University Medical City and College of Medicine, King Saud University, Riyadh, Saudi Arabia.

We report a case of a 36 year old gentleman presenting with polyneuropathy and Korsakkoff Syndrome complicating Sleeve Gastrectomy. Read More

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Time perception and alcohol use: A systematic review.

Neurosci Biobehav Rev 2021 Apr 29;127:377-403. Epub 2021 Apr 29.

Louvain Experimental Psychopathology Research Group, Psychological Science Research Institute, UClouvain, 10, place Cardinal Mercier, Louvain-la-Neuve, B-1348, Belgium. Electronic address:

Attentional, executive, and memory processes play a pivotal role in time perception. As acute or chronic alcohol consumption influences these processes, it should also modify time perception. We systematically reviewed and critically assessed all existing studies on time perception among alcohol drinkers, following the PICOS procedure and PRISMA guidelines. Read More

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Memantine Usage for Management of Korsakoff Syndrome in the Setting of Chronic Alcohol Use and Unspecified Eating Disorder.

Cureus 2021 Mar 12;13(3):e13846. Epub 2021 Mar 12.

Internal Medicine, Medical Center of Trinity, Trinity, USA.

Korsakoff syndrome is a neuropsychiatric condition frequently seen as a progression of Wernicke's encephalopathy and is often associated with long-term alcohol abuse. It is characterized by further cognitive impairments, such as indiscriminate anterograde and retrograde amnesia, in addition to executive function deficits. As the syndrome is a result of severe thiamine deficiency, its management primarily focuses on nutritional replenishment and electrolyte maintenance. Read More

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Intentional and unintentional mind-wandering in Korsakoff syndrome.

Psychiatry Res 2021 Jun 2;300:113921. Epub 2021 Apr 2.

Univ. Lille, CNRS, CHU Lille, UMR 9193 SCALab, Sciences Cognitives et Sciences Affectives, F-59000 Lille, France.

Mind-wandering refers to the intentional and unintentional tendency to withdraw from the external environment and engage in internally generated thoughts. We investigated intentional and unintentional mind-wandering in patients with Korsakoff syndrome (KS). We invited 31 patients with KS and 33 control participants to answer a questionnaire probing intentional and unintentional mind-wandering. Read More

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Autobiographical memory in Korsakoff syndrome: A review.

M El Haj

Encephale 2021 Apr 5. Epub 2021 Apr 5.

Nantes Université, University Angers, Laboratoire de Psychologie des Pays de la Loire (LPPL - EA 4638), 44000 Nantes, France; Unité de Gériatrie, Centre Hospitalier de Tourcoing, Tourcoing, France; Institut Universitaire de France, Paris, France. Electronic address:

Autobiographical memory (AM) (i.e., memory for personal information) is a unique form of memory that goes beyond recalling information such as what, where and when of an event, to include what that event means and why it is important to our life story. Read More

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Wernicke-Korsakoff Syndrome in Hyperemesis Gravidarum: A Case Report and Literature Review.

Neurohospitalist 2021 Apr 4;11(2):141-147. Epub 2020 Sep 4.

Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Philippines.

Background: Wernicke-Korsakoff syndrome (WKS) is a triad of ophthalmoplegia, ataxia and memory deficits due to thiamine insufficiency resulting from under- or untreated Wernicke's encephalopathy (WE), which may be associated with hyperemesis gravidarum (HEG).

Case Presentation: We present a case of a 36-year-old Filipino woman in her first trimester with HEG, along with the WKS triad and abnormal hyperintense signals in the bilateral thalami and midbrain, left occipital lobe, periaqueductal gray matter and pontine periventricular areas. Neurologic deficits partially improved but persisted despite intravenous thiamine administration. Read More

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Low rates of thiamine prescribing in adult patients with alcohol-related diagnoses in the emergency department.

Am J Drug Alcohol Abuse 2021 Mar 29:1-7. Epub 2021 Mar 29.

Department of Emergency Medicine, Columbia University Irving Medical Center, New York, NY, USA.

Alcohol use disorder (AUD) is associated with thiamine deficiency and Wernicke-Korsakoff Syndrome (WKS). Thiamine supplementation for the prevention of WKS in patients with suspected AUD in the Emergency Department (ED) is generally recommended. As alcohol-related diagnoses are frequent reasons for visits to EDs, ED thiamine prescribing practices are relevant to the overall management and prevention of WKS in patients with AUD. Read More

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Recognition of younger and older faces in Korsakoff's syndrome.

Appl Neuropsychol Adult 2021 Mar 24:1-8. Epub 2021 Mar 24.

UMR 9193 SCALab, Sciences Cognitives et Sciences Affectives, Univ. Lille, CNRS, CHU Lille, Lille, France.

The own-age bias refers to the observation that face recognition is typically superior for own-age faces compared with other-age faces. We investigated this bias in Korsakoff patients, as well as its relationship with social contact and episodic memory. Korsakoff patients and age-matched controls were exposed to older faces (own-age faces) and younger faces (other-age faces). Read More

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Repurposing Treatment of Wernicke-Korsakoff Syndrome for Th-17 Cell Immune Storm Syndrome and Neurological Symptoms in COVID-19: Thiamine Efficacy and Safety, In-Vitro Evidence and Pharmacokinetic Profile.

Front Pharmacol 2020 2;11:598128. Epub 2021 Mar 2.

Department of Medicine, University of Louisville, Louisville, KY, United States.

Coronavirus disease identified in 2019 (COVID-19) can be complicated by the Th17 cell-mediated IL-17 proinflammatory response. We tested if thiamine can effectively lower the Th17 response in a clinical study [Proinflammatory state in alcohol use disorder patients termed as disease controls (DC)] and corroborated the results using an study. We developed an effective dose range and model for key pharmacokinetic measures with the potential of targeting the cytokine storm and neurological symptoms of COVID-19. Read More

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Behavioural effects of light intervention in people with Korsakoff Syndrome: A pilot study.

Neuropsychol Rehabil 2021 Mar 8:1-16. Epub 2021 Mar 8.

Lelie Care Group, Slingedael Korsakoff Center, Rotterdam, Netherlands.

Korsakoff Syndrome (KS) is commonly associated with behavioural symptoms such as agitation, apathy, and disinhibition. People with KS often reside in long-term care facilities, which reduces their exposure to natural light. Little is known regarding positive effects of light intervention in KS. Read More

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Pharmacological enhancing agents targeting cognition in patients with alcohol-induced neurocognitive disorders: A systematic review.

Neurosci Biobehav Rev 2021 Jun 2;125:608-626. Epub 2021 Mar 2.

Unit for Psychiatric Research, Department of Clinical Research, University of Southern Denmark, Odense C, Denmark; Brain Research-Inter-Disciplinary Guided Excellence (BRIDGE), Department of Clinical Research, University of Southern Denmark, Odense C, Denmark.

Debilitating neurocognitive deficits are seen in alcohol use disorders (AUD) and Wernicke-Korsakoff's syndrome (WKS). These shared characteristics suggest a spectrum of alcohol-induced neurocognitive disorders (AIND). Cognitive pharmacological enhancing agents (CPEA) have been examined in the treatment of other psychiatric disorders, but little is known about the effects of these agents on AINDs. Read More

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Temporal Cognitive and Brain Changes in Korsakoff Syndrome.

Neurology 2021 04 26;96(15):e1987-e1998. Epub 2021 Feb 26.

From Normandie Université (A.M., A.L., N.C., C.B., F.E., F.V., S.S., A.-L.P.), UNICAEN, PSL Université Paris, EPHE, INSERM, U1077, CHU de Caen, GIP Cyceron, Neuropsychologie et Imagerie de la Mémoire Humaine; Service d'addictologie (N.C., C.B., F.V.), Centre Hospitalier Universitaire de Caen; Normandie Université (G.C.), UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders," Institut Blood and Brain at Caen-Normandie, Cyceron, Caen; Service d'addictologie (L.U.), Centre Hospitalier de Roubaix; and Institut Universitaire de France (A.-L.P.), Paris.

Objective: To investigate cognitive and brain changes in patients with Korsakoff syndrome (KS) over months and up to 10 years after the diagnosis.

Methods: Two groups of 8 patients with KS underwent neuropsychological, motor, and neuroimaging investigations, including structural MRI and F-fluorodeoxyglucose-PET. The KS group, recruited at Caen University Hospital, was examined early after the KS diagnosis (KS-T1) and 1 year later (KS-T2). Read More

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Nonalcoholic Wernicke-Korsakoff Syndrome Resulting From Psychosis.

J Nerv Ment Dis 2021 03;209(3):229-231

Psychiatry and Mental Health Department, Centro Hopitalar Universitário Lisboa Norte.

Abstract: Wernicke encephalopathy (WE) results from thiamine deficiency. If undiagnosed or inadequately treated, WE evolves into Korsakoff syndrome (KS). We herein report a case of nonalcoholic Wernicke-Korsakoff syndrome (WKS) that resulted from malnutrition due to psychosis in a 42-years-old male patient. Read More

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Nystagmus in non-alcoholic Wernicke encephalopathy.

BMJ Case Rep 2021 Feb 18;14(2). Epub 2021 Feb 18.

Department of Medicine, Okinawa Chubu Hospital, Uruma, Okinawa, Japan

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February 2021

An Unusual Presentation of Catatonia in Non-alcoholic Wernicke Encephalopathy.

Cureus 2021 Jan 6;13(1):e12537. Epub 2021 Jan 6.

Psychiatry, Cornerstone Healthcare System, Newburgh, USA.

Wernicke encephalopathy (WE) is an acute reaction to thiamine deficiency, which presents with the classic triad of ocular findings, cerebellar dysfunction, and confusion. However, thiamine deficiency can also present with several neuropsychiatric signs and symptoms other than the classical triad. We report a patient who presented with catatonia as a presenting feature of WE. Read More

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January 2021

High emotional experience during autobiographical retrieval in women with Korsakoff syndrome.

Cogn Neuropsychiatry 2021 03 10;26(2):136-148. Epub 2021 Feb 10.

Faculté de Psychologie, Laboratoire de Psychologie des Pays de la Loire (LPPL - EA 4638), Nantes Université, Université d'Angers, Nantes, France.

Introduction: In this exploratory study, we investigated gender differences regarding autobiographical memory in KS.

Method: We invited 33 patients with KS and 35 matched control participants to retrieve autobiographical memories and, afterward, to rate mental time travel during retrieval, emotional value and importance of memories.

Results: Analysis demonstrated lower specificity (i. Read More

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Wernicke encephalopathy in a patient with Burkitt lymphoma with typical and atypical findings on MRI.

BMJ Case Rep 2021 Feb 4;14(2). Epub 2021 Feb 4.

Pedeatric Oncology, Centro Hospitalar e Universitario de Coimbra EPE Hospital Pediátrico de Coimbra, Coimbra, Coimbra, Portugal.

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February 2021

Wernicke's encephalopathy - from basic science to clinical practice. Part 1: Understanding the role of thiamine.

Ther Adv Psychopharmacol 2020 29;10:2045125320978106. Epub 2020 Dec 29.

Department of Clinical Sciences, Division of Psychiatry, Sunderby Research Unit, Umeå University, Umeå, Sweden.

Wernicke's encephalopathy (WE) is an acute neuropsychiatric state. Untreated, WE can lead to coma or death, or progress to Korsakoff syndrome (KS) - a dementia characterized by irreversible loss of anterograde memory. Thiamine (vitamin B1) deficiency lies at the heart of this condition. Read More

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December 2020

A reappraisal of acute doses of benzodiazepines as a model of anterograde amnesia.

Hum Psychopharmacol 2021 May 26;36(3):e2774. Epub 2020 Dec 26.

Departamento de Psicobiologia, Universidade Federal de São Paulo- Escola Paulista de Medicina, Sao Paulo, Brazil.

Objective: Acute administration of benzodiazepines is considered a pharmacological model of general organic anterograde amnesias (OAA). We sought to determine which type of amnesia these drugs best model by comparing the effects of diazepam with those reported in amnesiacs regarding working memory capacity (WMC), susceptibility to retroactive interference (RI), and accelerated forgetting.

Methods: In this double-blind, parallel-group design study, 30 undergraduates were randomly allocated to acute oral treatments with 15 mg diazepam or placebo. Read More

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The Inferior Colliculus in Alcoholism and Beyond.

Front Syst Neurosci 2020 11;14:606345. Epub 2020 Dec 11.

Neuroscience Program, SRI International, Menlo Park, CA, United States.

Post-mortem neuropathological and neuroimaging methods have demonstrated the vulnerability of the inferior colliculus to the sequelae of thiamine deficiency as occurs in Wernicke-Korsakoff Syndrome (WKS). A rich literature in animal models ranging from mice to monkeys-including our neuroimaging studies in rats-has shown involvement of the inferior colliculi in the neural response to thiamine depletion, frequently accomplished with pyrithiamine, an inhibitor of thiamine metabolism. In uncomplicated alcoholism (i. Read More

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December 2020

Cerebellar and cortical TLR4 activation and behavioral impairments in Wernicke-Korsakoff Syndrome: Pharmacological effects of oleoylethanolamide.

Prog Neuropsychopharmacol Biol Psychiatry 2021 Jun 1;108:110190. Epub 2020 Dec 1.

Department of Psychobiology and Behavioral Sciences Methods, Faculty of Psychology, Universidad Complutense de Madrid (UCM), Madrid, Spain; Red de Trastornos Adictivos (RTA) del Instituto de Salud Carlos III (ISCIII), Spain. Electronic address:

Wernicke-Korsakoff Syndrome (WKS) is a neuropsychiatric disorder whose etiology is a thiamine deficiency (TD), with alcoholism being the main underlying cause. Previous evidence suggests the presence of initial neuroinflammation and oxidative/nitrosative stress in the physiopathology, although the specific molecular mechanisms underlying TD-induced brain damage and behavioral disabilities are unknown. We explored the specific role of the innate immune receptor TLR4 in three murine models of WKS, based on the combination of a thiamine-deficient diet and pyrithiamine injections (0. Read More

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Wernicke's Encephalopathy in Alcohol Use Disorder Patients after Liver Transplantation: A Case Series and Review of Literature.

J Clin Med 2020 Nov 25;9(12). Epub 2020 Nov 25.

Alcohol Use Disorder and Alcohol Related Disease Unit, Department of Internal Medicine and Gastroenterology, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.

Wernicke's encephalopathy (WE) is an acute neurological disorder resulting from thiamine deficiency, commonly found in alcohol use disorder (AUD) patients. Liver transplantation (LT) could represent a risk factor for the onset of WE in AUD patients, due to the onset of chronic depletion of thiamine in this population and the high metabolic demand of surgery and the postoperative period. However, few data are available about the risk of the onset of WE in AUD patients after LT. Read More

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November 2020

Moral reasoning, moral decision-making, and empathy in Korsakoff's syndrome.

J Neuropsychol 2020 Nov 27. Epub 2020 Nov 27.

Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, The Netherlands.

Korsakoff's syndrome (KS) is a neuropsychiatric disorder, caused by a vitamin B1 deficiency. Although it is known that patients with KS display diminished theory of mind functioning and frequently exhibit marked antisocial interactions little attention has so far focused on the integrity of moral decision-making abilities, moral reasoning, and empathy. In an experimental cross-sectional design, 20 patients diagnosed with KS, and twenty age-, education-, and gender-equivalent healthy participants performed tests assessing moral decision-making, moral reasoning maturity, empathy, and executive functioning. Read More

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November 2020