1,019 results match your criteria Wernicke-Korsakoff Syndrome


Neuro-ophthalmic Manifestations of Wernicke Encephalopathy.

Eye Brain 2020 30;12:49-60. Epub 2020 Jun 30.

Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, AL, USA.

Wernicke encephalopathy (WE) is a life-threatening but reversible syndrome resulting from acute thiamine deficiency that is frequently overlooked and underdiagnosed. It is classically characterized by a triad of ocular dysfunction, ataxia, and altered mental status. However, less than 1/3 patients have the complete triad, so it is crucial to have a high index of suspicion. Read More

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http://dx.doi.org/10.2147/EB.S234078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335288PMC

Design of a Randomized Placebo Controlled Trial of High Dose Intravenous Thiamine for the Prevention of Delirium in Allogeneic Hematopoietic Stem Cell Transplantation.

Contemp Clin Trials 2020 Jun 30:106076. Epub 2020 Jun 30.

Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Medicine, Division of Hematology/Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Background: Delirium is a highly prevalent and preventable neuropsychiatric condition with major health consequences. Thiamine deficiency is a well-established cause of delirium in those with chronic, severe alcoholism, but there remains an underappreciation of its significance in non-alcoholic populations, including patients with cancer. Treatment of suspected thiamine-related mental status changes with high dose intravenous (IV) thiamine has preliminary evidence for improving a variety of cognitive symptoms in oncology inpatient settings but has never been studied for the prevention of delirium in any population. Read More

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http://dx.doi.org/10.1016/j.cct.2020.106076DOI Listing

From psychosis to Wernicke encephalopathy: a case of hunger strike in prison.

Neurocase 2020 Jun 26:1-4. Epub 2020 Jun 26.

Department of Psychiatry, Erenköy Mental Health and Neurology, Training&Research Hospital , İstanbul, Turkey.

Wernicke encephalopathy (WE) is a neuropsychiatric condition associated with  thiamine deficiency that includes a triad of mental status changes, ophthalmoplegia, and ataxia. Worsening WE may lead to Korsakoff syndrome(KS), in which cognitive impairments such as confabulation and memory deficits and also psychiatric symptoms may occur. Diagnosis of Wernicke-Korsakoff syndrome can be complicated in many cases. Read More

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http://dx.doi.org/10.1080/13554794.2020.1786587DOI Listing

Caregivers' perspectives on good care for nursing home residents with Korsakoff syndrome.

Nurs Ethics 2020 May 21:969733020921507. Epub 2020 May 21.

Amsterdam UMC, the Netherlands.

Background: In the Netherlands, people with severe cognitive deficits due to Korsakoff syndrome are generally admitted to a specialized nursing home. Professional caregivers experience that these residents are often not aware of their deficits, and consequently, their willingness to accept care is relatively low. However, these residents need permanent support when performing daily tasks due to severe cognitive deficits. Read More

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http://dx.doi.org/10.1177/0969733020921507DOI Listing

Episodic future thinking together with observational learning benefits prospective memory in high-functioning Korsakoff's syndrome patients.

Br J Clin Psychol 2020 May 18:e12251. Epub 2020 May 18.

Helmholtz Institute, Experimental Psychology, Utrecht University, The Netherlands.

Objective: Patients with Korsakoff's syndrome (KS) have difficulty carrying out tasks which rely on prospective memory (PM). Since remembering to carry out an action in the future is crucial for living independently, it is of primary interest to develop strategies that improve PM performance in KS patients.

Design: The study employed a computer categorization task as an ongoing activity into which a PM task was embedded. Read More

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http://dx.doi.org/10.1111/bjc.12251DOI Listing

Wernicke-Korsakoff Syndrome: A Case Series in Liaison Psychiatry.

Prim Care Companion CNS Disord 2020 May 7;22(3). Epub 2020 May 7.

Department of Psychiatry, Prof. Dr. Fernando da Fonseca Hospital, Amadora, Portugal.

Wernicke-Korsakoff syndrome (WKS) is a life-threatening and underdiagnosed neuropsychiatric condition caused by thiamine deficiency that comprises Wernicke encephalopathy and Korsakoff syndrome. Although mainly associated with chronic alcoholism, WKS can arise from other circumstances. This report describes a series of cases of WKS that were clinically evaluated by liaison psychiatrists on a nonpsychiatric inpatient unit. Read More

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http://dx.doi.org/10.4088/PCC.19br02538DOI Listing

[Wernicke Korsakoff Syndrome in a Pregnant Woman - the Interesting Case].

Klin Monbl Augenheilkd 2020 Apr 24;237(4):521-523. Epub 2020 Apr 24.

Klinik für Augenheilkunde, Hippokration Krankenhaus, Thessaloniki, Griechenland.

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http://dx.doi.org/10.1055/a-1097-5534DOI Listing

Egocentric and Allocentric Spatial Memory in Korsakoff's Amnesia.

Front Hum Neurosci 2020 31;14:121. Epub 2020 Mar 31.

Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, Netherlands.

The goal of the present study was to investigate spatial memory in a group of patients with amnesia due to Korsakoff's syndrome (KS). We used a virtual spatial memory task that allowed us to separate the use of egocentric and allocentric spatial reference frames to determine object locations. Research investigating the ability of patients with Korsakoff's amnesia to use different reference frames is scarce and it remains unclear whether these patients are impaired in using ego- and allocentric reference frames to the same extent. Read More

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http://dx.doi.org/10.3389/fnhum.2020.00121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136515PMC

Acute amnestic syndromes.

J Neurol Sci 2020 Jun 18;413:116781. Epub 2020 Mar 18.

Department of Cognitive Neurology, Neuropsychiatry and Neuropsychology, Raúl Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina.

Acute amnestic syndromes are usually rare clinical events occurring in emergency situations. Etiological diagnosis can be challenging and underlying causes diverse. They can be transient and totally reversible, or accompanied by other neurological symptoms resulting in serious and irreversible brain damage. Read More

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http://dx.doi.org/10.1016/j.jns.2020.116781DOI Listing

The relationship between executive dysfunction and neuropsychiatric symptoms in patients with Korsakoff's syndrome.

Clin Neuropsychol 2020 May 19;34(4):740-754. Epub 2020 Mar 19.

Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.

: Patients with Korsakoff's syndrome (KS) show executive dysfunction and neuropsychiatric symptoms. This study investigates whether specific executive subcomponents (shifting, updating, and inhibition) predict variance in neuropsychiatric symptoms. We hypothesized that shifting deficits, in particular, are associated with neuropsychiatric symptoms. Read More

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http://dx.doi.org/10.1080/13854046.2020.1738554DOI Listing

Thiamine (vitamin B1) in septic shock: a targeted therapy.

J Thorac Dis 2020 Feb;12(Suppl 1):S78-S83

Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Thiamine (vitamin B1) is a water-soluble vitamin essential for human health. Thiamine deficiency is causal and/or contributory in a number of debilitating diseases including beri-beri, the Wernicke-Korsakoff syndrome, optic neuropathy, and others. While thiamine deficiency is relatively rare in developed nations as a result of dietary supplementation, thiamine deficiency is more common in nutritionally compromised populations. Read More

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http://dx.doi.org/10.21037/jtd.2019.12.82DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024754PMC
February 2020

Alcohol use disorders and the brain.

Addiction 2020 Aug 17;115(8):1580-1589. Epub 2020 Mar 17.

University of Oxford, Big Data Institute, Nuffield Department of Population Health.

A diagnosis of alcohol use disorder is associated with a higher risk of dementia, but a dose-response relationship between alcohol intake consumption and cognitive impairment remains unclear. Alcohol is associated with a range of effects on the central nervous system at different doses and acts on a number of receptors. Acute disorders include Wernicke's encephalopathy (WE), traumatic brain injury, blackouts, seizures, stroke and hepatic encephalopathy. Read More

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http://dx.doi.org/10.1111/add.15023DOI Listing

The effects of strategy training on spatial memory in diencephalic amnesia: a randomized controlled study.

Cogn Process 2020 May 17;21(2):315-319. Epub 2020 Feb 17.

Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.

Alcoholic Korsakoff's syndrome is characterized by severe amnesia, also affecting spatial memory. To date, research on cognitive rehabilitation in these patients is scarce. Aim of the present study is to examine the efficacy of a mnemonic strategy training in patients with Korsakoff's syndrome. Read More

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http://dx.doi.org/10.1007/s10339-020-00961-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203089PMC

Visual working memory capacity in Korsakoff's amnesia.

J Clin Exp Neuropsychol 2020 May 6;42(4):363-370. Epub 2020 Feb 6.

Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, The Netherlands.

: Despite the interest in memory functioning in Korsakoff's syndrome (KS), visual working memory capacity in KS is still poorly understood. Results from the last decades on working memory limitations in KS appear to be mixed, clearly calling for further investigations.: We investigated visual working memory storage capacity of patients diagnosed with KS using a change detection paradigm. Read More

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http://dx.doi.org/10.1080/13803395.2020.1722800DOI Listing

Alcohol and Dementia - What is the Link? A Systematic Review.

Neuropsychiatr Dis Treat 2020 9;16:87-99. Epub 2020 Jan 9.

Department of Psychiatry and Psychotherapy, Psychiatric Hospital of Charité at St. Hedwig Hospital, Berlin, Germany.

Background: Dementia is a globally increasing health issue and since no cure is currently available, prevention is crucial. The consumption of alcohol is a controversially discussed risk factor for dementia. While many previously published epidemiological studies reported a risk reduction by light to moderate alcohol consumption, there is no persuasive model of an underlying biochemical mechanism. Read More

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http://dx.doi.org/10.2147/NDT.S198772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957093PMC
January 2020

The image of memory: relationship between autobiographical memory and mental imagery in Korsakoff syndrome.

Appl Neuropsychol Adult 2020 Jan 29:1-7. Epub 2020 Jan 29.

University of Nantes, Nantes, France.

We evaluated the relationship between autobiographical memory and mental imagery in Korsakoff syndrome (KS). We invited patients with KS and control participants to retrieve personal events and to perform measures of visual imagery (Taller/Wilder task), and spatial imagery (Clock Angles task). On the Taller/Wilder task, participants had to generate a mental image of an object presented as a word and determine whether the object was taller than it was wide. Read More

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http://dx.doi.org/10.1080/23279095.2020.1716759DOI Listing
January 2020

Sex Differences in Korsakoff's Syndrome for Inhibition but Not for Episodic Memory or Flexibility.

Am J Addict 2020 03 15;29(2):129-133. Epub 2020 Jan 15.

CNRS, CHU Lille, UMR 9193 SCALab-Sciences Cognitives et Sciences Affectives, University of Lille, F-59000, Lille, France.

Background And Objectives: While sex differences in cognitive abilities have been extensively studied in healthy populations, little is known about these differences in patients with Korsakoff syndrome (KS).

Methods: We investigated sex differences in verbal episodic memory, inhibition, and flexibility in 25 patients with KS and 25 control participants.

Results: The analysis demonstrated no significant differences between women with KS and men with KS on episodic memory and flexibility, but higher inhibition was observed in women with KS compared with men with KS. Read More

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http://dx.doi.org/10.1111/ajad.12999DOI Listing

Confabulations in Alcoholic Korsakoff's Syndrome: A Factor Analysis of the Nijmegen-Venray Confabulation List.

Assessment 2020 Jan 12:1073191119899476. Epub 2020 Jan 12.

Vincent van Gogh Institute for Psychiatry, Venray, Netherlands.

Confabulations generally refer to the emergence of memories of experiences and events that, in reality, never took place, and which are unintentionally produced. They are frequently observed in alcoholic Korsakoff's syndrome. The aim of the current study was to validate the Nijmegen-Venray Confabulation List (NVCL), an observation scale for quantifying both spontaneous and provoked confabulations. Read More

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http://dx.doi.org/10.1177/1073191119899476DOI Listing
January 2020

[The 473rd case: renal failure, abdominal pain, and mental abnormality].

Zhonghua Nei Ke Za Zhi 2020 Jan;59(1):82-85

Department of Nephrology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

A 43-year-old male presented with elevated serum creatinine for 4 years and developed abdominal pain for 3 days. He started peritoneal dialysis 2 months ago. Dialysis-related peritonitis was ruled out and acute gastroenteritis was diagnosed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1426.2020.01.016DOI Listing
January 2020

Health problems and care needs in patients with Korsakoff's syndrome: A systematic review.

J Psychiatr Ment Health Nurs 2019 Dec 26. Epub 2019 Dec 26.

Department of Experimental Psychology, Helmholtz Research Institute, Utrecht University, the Netherlands.

WHAT IS KNOWN ON THE SUBJECT?: Patients with Korsakoff's syndrome suffer from a broad range of comorbid somatic and/or psychiatric conditions. The various health problems in patients with Korsakoff's syndrome limit their ability to perform daily activities and also negatively affect their social functioning. WHAT THE PAPER ADDS TO EXISTING KNOWLEDGE?: Patients with Korsakoff's syndrome have complex somatic and psychiatric comorbid conditions co-occurring with behavioural and functional problems. Read More

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http://dx.doi.org/10.1111/jpm.12587DOI Listing
December 2019

Wernicke-Korsakoff Syndrome in a Patient With Celiac Disease and Obsessive-Compulsive Disorder: A Case Report.

Psychosomatics 2020 Jul - Aug;61(4):375-378. Epub 2019 Oct 10.

Consultation-Liaison Psychiatry, Department of Psychiatry and Human Behavior, Thomas Jefferson University Hospital, Philadelphia, PA.

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http://dx.doi.org/10.1016/j.psym.2019.09.007DOI Listing
October 2019
8 Reads

Atrophic mammillary bodies with hypointensities on susceptibility-weighted images: A case-study in Korsakoff syndrome.

J Neurol Sci 2020 01 1;408:116551. Epub 2019 Nov 1.

Department of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Yazakokarimata 1-1, Nagakute, Aichi, Japan.

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http://dx.doi.org/10.1016/j.jns.2019.116551DOI Listing
January 2020
1 Read

Prevalence and Improvement of Caine-Positive Wernicke-Korsakoff Syndrome in Psychiatric Inpatient Admissions.

Psychosomatics 2020 Jan - Feb;61(1):31-38. Epub 2019 Aug 14.

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD.

Background: Wernicke-Korsakoff Syndrome (WKS) resulting from thiamine deficiency is classically defined as including encephalopathy, ataxia, and ophthalmoplegia. Only 16% of autopsy-confirmed patients with WKS exhibit all three signs. Caine-positive WKS criteria include two or more of the following: nutritional deficiency, delirium or mild memory impairment, cerebellar dysfunction/ataxia, and oculomotor abnormalities. Read More

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http://dx.doi.org/10.1016/j.psym.2019.08.002DOI Listing
August 2019
1 Read

Incidence of Adverse Reactions to Parenteral Thiamine in the Treatment of Wernicke's Encephalopathy, and Recommendations.

Alcohol Alcohol 2019 Dec;54(6):609-614

King's College London, Institute of Psychiatry, Psychology and Neuroscience London SE5 8AF, UK.

Aim: To offer an estimate of the incidence of anaphylactic reactions to parenteral products containing thiamine used in the treatment of Wernicke's encephalopathy (WE) and make recommendations.

Method: Review of previously released data on some older products and parenteral thiamine use in some other countries; analysis of sales and adverse incident data on anaphylaxis for a contemporary parenteral product used in the UK, Pabrinex.

Results: It was difficult to estimate the incidence of related anaphylactic reactions to Pabrinex in the UK because the number of doses given is unknown. Read More

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http://dx.doi.org/10.1093/alcalc/agy091DOI Listing
December 2019
6 Reads

Personality and Psychopathology in Adults with Noonan Syndrome.

J Clin Psychol Med Settings 2020 Jun;27(2):256-267

Centre of Excellence for Neuropsychiatry, Vincent van Gogh Institute for Psychiatry, P.O. Box 5, 5800 AA, Venray, The Netherlands.

This is the first controlled study regarding personality and psychopathology in adults with Noonan syndrome (NS). Anxiety, depression, alexithymia and symptoms of Attention Deficit-Hyperactivity Disorder and Autism Spectrum Disorder, have been previously described in NS. More information regarding personality and psychopathology in NS could improve mental health care for this population. Read More

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http://dx.doi.org/10.1007/s10880-019-09659-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217811PMC
June 2020
6 Reads

Endoscopic resection of the third ventricular epidermoid cysts: A case review and review of literature.

Surg Neurol Int 2019 7;10:98. Epub 2019 Jun 7.

Departments of Neurosurgery, Kaiser Permanente Fontana Medical Center, Fontana, United States.

Background: Epidermoid cysts are benign, congenital lesions that originate from ectodermal cells, they are most commonly found in the cerebellopontine angle, but rarely in the ventricular system. There is limited literature regarding the different microsurgical techniques utilized to approach these lesions.

Methods: A 63-year-old female with a recurrent third ventricular epidermoid cyst underwent gross total resection utilizing an endoscopic technique. Read More

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http://dx.doi.org/10.25259/SNI-233-2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744775PMC
June 2019
9 Reads

A view from the acute hospital: managing patients with alcohol problems.

Br J Hosp Med (Lond) 2019 Sep;80(9):500-506

Consultant Psychiatrist, Solihull Integrated Addiction Service, Institute for Mental Health, University of Birmingham B15 2TT.

Regular heavy consumption of alcohol is associated with a wide range of physical, psychological and social problems. All health-care clinicians should be able to screen for and detect problematic levels of alcohol consumption in their patients, and deliver an effective brief intervention. When patients with alcohol dependence are admitted to hospital there must be an assessment of whether medication is required to prevent withdrawal symptoms and potential delirium tremens and withdrawal seizures. Read More

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http://dx.doi.org/10.12968/hmed.2019.80.9.500DOI Listing
September 2019
5 Reads
0.366 Impact Factor

Brain 18FDG-PET pattern in patients with alcohol-related cognitive impairment.

Eur J Nucl Med Mol Imaging 2020 Feb 19;47(2):281-291. Epub 2019 Aug 19.

Département de Psychiatrie et de Médecine Addictologique, Groupe Hospitalier Saint-Louis Lariboisière Fernand-Widal, Hôpital Fernand Widal, Paris, France.

Purpose: Brain positron emission tomography using 18F-fluorodeoxyglucose (18FDG-PET) provides a metabolic assessment of brain function that is useful for differential diagnosis among several neurodegenerative diseases manifested by cognitive impairment (CI). The purpose of the study is to describe the pattern of 18FDG-PET abnormalities in patients with CI related to alcohol use disorder.

Methods: Patients admitted to the addiction medicine department of a university hospital in Paris between January 2017 and October 2018 with a confirmed diagnosis of alcohol-related cognitive impairment (ARCI) or Wernicke encephalopathy (WE) were included. Read More

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http://dx.doi.org/10.1007/s00259-019-04487-1DOI Listing
February 2020
2 Reads

Vitamin D supplementation after malnutrition associated with time-related increase of cancer diagnoses: A cohort study of 389 patients with Wernicke-Korsakoff syndrome.

Nutrition 2019 10 29;66:166-172. Epub 2019 May 29.

Slingedael Korsakoff Center, Lelie Care Group, Rotterdam, The Netherlands; Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, The Netherlands.

Objectives: Vitamin deficiencies may reflect less-than-optimal health in select populations. The aim of this study was to determine whether vitamin D supplementation (VDs) after malnutrition may be adversely related to cancer diagnoses in a selected group of patients with alcoholic Wernicke-Korsakoff syndrome (WKS).

Method: This was a retrospective cohort study of all patients admitted to Slingedael Korsakoff Center, from 1996 to 2018. Read More

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http://dx.doi.org/10.1016/j.nut.2019.05.008DOI Listing
October 2019
3 Reads

Subtle object location perception deficits in Korsakoff's syndrome.

J Clin Exp Neuropsychol 2019 11 14;41(9):881-887. Epub 2019 Jul 14.

Department of Experimental Psychology, Helmholtz Institute, Utrecht University , Utrecht , The Netherlands.

(Wernicke-)Korsakoff's syndrome (KS) is a neuropsychiatric syndrome, caused by vitamin B1 (thiamine) deficiency often resulting from chronic alcohol consumption. KS is characterized by severe cognitive problems, such as impaired explicit memory and executive functions. Visuospatial perception (VSP) refers to the identification of objects (object perception), and the localization of objects (space perception). Read More

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http://dx.doi.org/10.1080/13803395.2019.1640864DOI Listing
November 2019
7 Reads

Hyperemesis gravidarum causing Wernicke-Korsakoff syndrome: A rare complication.

J Obstet Gynaecol Res 2019 Sep 19;45(9):1929-1931. Epub 2019 Jun 19.

Department of Obstetrics and Gynaecology, Reproductive Medicine and Laparoscopy, Mothercare Hospital, Margao, Goa, India.

Wernicke-Korsakoff syndrome (WKS) is a rare neurological disorder due to severe thiamine deficiency. It is most prevalent among alcoholics. However in nonalcoholics the prevalence varies from 0. Read More

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http://dx.doi.org/10.1111/jog.14039DOI Listing
September 2019
18 Reads

[Neurological consequences of alcoholism].

Authors:
E Fouarge P Maquet

Rev Med Liege 2019 May;74(5-6):310-313

Service de Neurologie, CHU Liège, Belgique.

Chronic alcohol consumption results in multiple peripheral and central nervous system dysfunctions. Some are due to the direct action of alcohol or its derivatives, others are induced by the vitamin deficiencies associated with alcoholism, others are eventually related to the failure of other vital organs, such as the liver. In this short review, we describe alcohol-induced neuropathy, Gayet-Wernicke syndrome, Korsakoff syndrome, alcoholic dementia, Marchiafava-Bignami syndrome, hepatic encephalopathy, alcoholic epilepsy and manifestations of alcohol withdrawal. Read More

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May 2019
20 Reads

A patient with Korsakoff syndrome of psychiatric and alcoholic etiology presenting as DSM-5 mild neurocognitive disorder.

Neuropsychiatr Dis Treat 2019 22;15:1311-1320. Epub 2019 May 22.

Department of Psychiatry, University of Turku, Turku, Finland.

Wernicke's encephalopathy (WE) and Korsakoff syndrome (KS) are underdiagnosed. The DSM-5 has raised the diagnostic threshold by including KS in the major neurocognitive disorders, which requires that the patient needs help in everyday activities. We report clinical, neuropsychological, and radiological findings from a patient who developed Wernicke-Korsakoff syndrome as a result of alcohol use and weight loss due to major depression. Read More

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http://dx.doi.org/10.2147/NDT.S203513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535456PMC
May 2019
7 Reads

Wernicke Encephalopathy-Clinical Pearls.

Mayo Clin Proc 2019 06;94(6):1065-1072

Department of Psychiatry and Psychology, Mayo Clinic College of Medicine and Science, Rochester, MN.

Wernicke encephalopathy (WE) was first described by Carl Wernicke in 1881. WE is caused by thiamine deficiency. Alcoholism is the most common etiologic factor associated with WE in the United States, but it can occur in any patient with a nutritional deficiency state such as hyperemesis gravidarum, intestinal obstruction, and malignancy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00256196193025
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http://dx.doi.org/10.1016/j.mayocp.2019.02.018DOI Listing
June 2019
9 Reads

Future Thinking in Korsakoff Syndrome.

Alcohol Alcohol 2019 Jul;54(4):455-462

Univ. Lille, CNRS, CHU Lille, UMR 9193-SCALab-Sciences Cognitives et, Sciences Affectives, Lille, France.

Aims: Prior research has been mainly concerned with the ability of patients with Korsakoff syndrome (KS) to project themselves into the past. Little is known about the patients' ability to project themselves into the future. We therefore compared past and future thinking in patients with KS. Read More

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https://academic.oup.com/alcalc/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/alcalc/agz037DOI Listing
July 2019
22 Reads

Thalamus: a key player in alcohol use disorder and Korsakoff's syndrome.

Brain 2019 05;142(5):1170-1172

Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1093/brain/awz096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487327PMC
May 2019
1 Read

Response to Oudman.

Int Psychogeriatr 2019 08;31(8):1227

Vincent van Gogh Institute for Psychiatry, Center of Excellence for Korsakoff and alcohol related cognitive disorders, PO Box 5 5800 AA, Venray, the Netherlands.

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http://dx.doi.org/10.1017/S1041610218001734DOI Listing
August 2019
6 Reads

Errorless skill learning in long-term Korsakoff care.

Authors:
Erik Oudman

Int Psychogeriatr 2019 08;31(8):1225

Department of Experimental Psychology, Utrecht University, Helmholtz Institute, Utrecht, the Netherlands.

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http://dx.doi.org/10.1017/S1041610218001667DOI Listing
August 2019
2 Reads

Smartwatch aids time-based prospective memory in Korsakoff syndrome: a case study.

Neurocase 2019 Feb - Apr;25(1-2):21-25. Epub 2019 Apr 10.

a Helmhotz Institute, Experimental Psychology , Utrecht University , Utrecht , The Netherlands.

Prospective memory (PM) is the ability to remember to carry out an intention in the future. PM is particularly impaired in Korsakoff syndrome (KS). We investigated the benefit of a smartwatch and smartphone compared to no aid in supporting time accuracy and PM task performance in KS. Read More

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http://dx.doi.org/10.1080/13554794.2019.1602145DOI Listing
December 2019
6 Reads

Ischaemic stroke of the fornix and genu of the corpus callosum presenting with a Korsakoff-like syndrome.

BMJ Case Rep 2019 Mar 31;12(3). Epub 2019 Mar 31.

Neurology Department, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Salford, UK.

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http://dx.doi.org/10.1136/bcr-2018-228506DOI Listing
March 2019
8 Reads

Thiamine Substitution in Alcohol Use Disorder: A Narrative Review of Medical Guidelines.

Eur Addict Res 2019 21;25(3):103-110. Epub 2019 Mar 21.

Clinical Division of Social Psychiatry, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.

Aims: Patients with alcohol use disorder (AUD) frequently suffer from cognitive deficits ranging from mild symptoms to most severe forms. Wernicke encephalopathy (WE), caused by thiamine deficiency, is a potentially fatal syndrome characterized by the clinical triad of ophthalmoplegia, ataxia, and confusion. WE frequently presents in patients with AUD and, if left untreated, can progress to Wernicke-Korsakoff syndrome, which constitutes severe anterograde amnesia, confabulation, and behavioral abnormalities. Read More

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https://www.karger.com/Article/FullText/499039
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http://dx.doi.org/10.1159/000499039DOI Listing
August 2019
39 Reads

Wernicke's encephalopathy in hyperemesis gravidarum: A systematic review.

Eur J Obstet Gynecol Reprod Biol 2019 May 12;236:84-93. Epub 2019 Mar 12.

Experimental Psychology, Helmholtz Institute, Utrecht University, the Netherlands; Korsakoff Center Slingedael, Lelie Care Group, Rotterdam, the Netherlands.

Pregnant women have an increased demand for thiamine. In hyperemesis gravidarum (HG) thiamine rapidly depletes, which can lead to Wernicke's Encephalopathy (WE). Our objective was to systematically review the signs and symptoms of WE in HG. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.03.006DOI Listing
May 2019
9 Reads

Social cognitive training for adults with Noonan syndrome: a feasibility study.

Neuropsychiatr Dis Treat 2019 26;15:611-626. Epub 2019 Feb 26.

Centre of Excellence for Neuropsychiatry, Vincent van Gogh Institute for Psychiatry, Venray, The Netherlands,

Purpose: Noonan syndrome (NS) is a genetic disorder that is associated with social cognitive problems. While treatment aimed at the improvement of social cognition is available for other neuropsychiatric disorders, no such interventions yet exist for NS patients. In this study, the development of the first social cognitive training for NS patients is described and its applicability and feasibility evaluated. Read More

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http://dx.doi.org/10.2147/NDT.S179527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396661PMC
February 2019
9 Reads

Dissociating thalamic alterations in alcohol use disorder defines specificity of Korsakoff's syndrome.

Brain 2019 05;142(5):1458-1470

Normandie Univ, UNICAEN, PSL Research University, EPHE, INSERM, U1077, CHU de Caen, Cyceron, Neuropsychologie et Imagerie de la Mémoire Humaine, Caen, France.

The thalamus, a relay organ consisting of several nuclei, is shared between the frontocerebellar circuit and the Papez circuit, both particularly affected in alcohol use disorder. Shrinkage of the thalamus is known to be more severe in alcoholics with Korsakoff's syndrome than in those without neurological complications (uncomplicated alcoholics). While thalamic atrophy could thus be a key factor explaining amnesia in Korsakoff's syndrome, the loci and nature of alterations within the thalamic nuclei in uncomplicated alcoholics and alcoholics with Korsakoff's syndrome remains unclear. Read More

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http://dx.doi.org/10.1093/brain/awz056DOI Listing
May 2019
5 Reads

Dry Beriberi Due to Thiamine Deficiency Associated with Peripheral Neuropathy and Wernicke's Encephalopathy Mimicking Guillain-Barré syndrome: A Case Report and Review of the Literature.

Am J Case Rep 2019 Mar 13;20:330-334. Epub 2019 Mar 13.

Department of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO, USA.

BACKGROUND Beriberi due to thiamine (vitamin B1) deficiency has two clinical presentations. Patients with dry beriberi present with neuropathy, and patients with wet beriberi present with heart failure, with or without neuropathy. Dry beriberi can mimic the most common form of Guillain-Barre syndrome (GBS), an acute inflammatory demyelinating polyradiculoneuropathy (AIDP). Read More

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http://dx.doi.org/10.12659/AJCR.914051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429982PMC
March 2019
71 Reads

Neuropsychological and Neuroimaging Examinations of Self-Reported Sleep Quality in Alcohol Use Disorder With and Without Korsakoff's Syndrome.

Alcohol Clin Exp Res 2019 05 29;43(5):952-964. Epub 2019 Mar 29.

U1077, CHU de Caen , GIP Cyceron, Neuropsychologie et Imagerie de la Mémoire Humaine, Normandy Univ, UNICAEN, PSL Université, EPHE, INSERM, Caen, France.

Background: Alcohol use disorder (AUD) patients without Korsakoff's syndrome (KS) report a variable self-rated sleep quality. Their ability to accurately judge their sleep quality may be related to their alcohol-related cognitive deficits and brain damage. KS patients, who present severe brain dysfunction, may be cognitively unable to judge their sleep quality. Read More

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http://dx.doi.org/10.1111/acer.13997DOI Listing
May 2019
8 Reads

Awareness and its relationships with neuropsychiatric symptoms in people with Korsakoff syndrome or other alcohol-related cognitive disorders living in specialized nursing homes.

Int J Geriatr Psychiatry 2019 06 15;34(6):836-845. Epub 2019 Apr 15.

Department of General Practice and Elderly Care Medicine, Amsterdam Public Health research institute, VU University Medical Center, Amsterdam, The Netherlands.

Objectives: Impaired awareness of functional deficits is often observed in people with Korsakoff syndrome (KS) and may result in refusal of care, although this area has been understudied. This study aimed to investigate levels of impaired awareness and their relationships with neuropsychiatric symptoms (NPS) in people with KS residing in specialized nursing homes.

Methods: A cross-sectional, observational study was conducted among 215 residents with KS or other alcohol-related cognitive disorders. Read More

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http://doi.wiley.com/10.1002/gps.5093
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http://dx.doi.org/10.1002/gps.5093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593674PMC
June 2019
17 Reads

Wernicke-Korsakoff syndrome: Focus on low-threshold diagnosis and prompt treatment in the primary care setting.

Int J Psychiatry Med 2019 05 1;54(3):172-180. Epub 2019 Mar 1.

1 UCSF Fresno Psychiatry Residency Training Program, Fresno, CA, USA.

The authors present the case of an inpatient hospitalized at the Veterans Affairs psychiatric unit diagnosed with Wernicke-Korsakoff syndrome to promote awareness of this prevalent yet often underdiagnosed and undertreated condition. Although Veterans present with a unique predisposition for alcohol abuse, it remains problematic in the general population as well. Analysis from 2000 to 2003 reveals alcohol use in the past month in Veterans at 56. Read More

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http://dx.doi.org/10.1177/0091217419832771DOI Listing
May 2019
39 Reads