Mutat Res 2018 Feb 9;826:47-52. Epub 2017 Dec 9.
CSIRO Health and Biosecurity, Personalised Nutrition & Healthy Ageing, Gate 13, Kintore Ave, Adelaide, South Australia, 5000, Australia; University of Adelaide, Department of Molecular and Cellular Biology, School of Biological Sciences, Adelaide, South Australia, 5005, Australia. Electronic address:
Guanine-quadruplexes (G4) are stable tetra-stranded DNA structures that may cause DNA replication stress and inhibit gene expression. Defects in unwinding these structures by DNA helicases may result in telomere shortening and DNA damage. Furthermore, due to mutations in WRN helicase genes in Werner syndrome, G4 motifs are likely to be key elements in the expression of premature aging phenotypes. Read More