21,986 results match your criteria Werner Syndrome
J Neurophysiol 2018 Dec 12. Epub 2018 Dec 12.
Werner Reichardt Centre for Integrative Neuroscience, Germany.
Two main types of small eye movements occur during gaze fixation: microsaccades and slow ocular drifts. While microsaccade generation has been relatively well-studied, ocular drift control mechanisms are unknown. Here we explored the degree to which monkey smooth eye movements, on the velocity scale of slow ocular drifts, can be generated systematically. Read More
Pediatr Cardiol 2018 Dec 11. Epub 2018 Dec 11.
Department of Cardiology, Pediatric Heart Centre, University Children's Hospital Zurich, Steinwiesstr. 75, 8032, Zurich, Switzerland.
The absence of cardiac symptoms, the improved exercise tolerance and the increased life expectancy are the advantages of a successful cardiac device therapy. Nevertheless, the fact of a lifelong device dependency, the inherent possibility of device malfunction and the progression of the underlying heart disease may impact the health-related quality of life (HRQoL) and the psychological adjustment of these individuals. To date, an overview of findings on these topics is lacking. Read More
Science 2018 Dec 11. Epub 2018 Dec 11.
U.S. Geological Survey, National Civil Applications Center, 12201 Sunrise Valley Dr., MS-562, Reston, VA 20192, USA.
In 2018, Kīlauea Volcano experienced its largest lower East Rift Zone (LERZ) eruption and caldera collapse in at least 200 years. After collapse of the Pu'u 'Ō'ō vent on 30 April, magma propagated downrift. Eruptive fissures opened in the LERZ on 3 May, eventually extending ~6. Read More
J Control Release 2018 Dec 8. Epub 2018 Dec 8.
Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 1-5, 8093 Zurich, Switzerland.
In glioblastoma, the benefit from temozolomide chemotherapy is largely limited to a subgroup of patients (30-35%) with tumors exhibiting methylation of the promoter region of the O-methylguanine-DNA methyltransferase (MGMT) gene. In order to allow more patients to benefit from this treatment, we explored magnetic resonance image-guided microbubble-enhanced low-intensity pulsed focused ultrasound (LIFU) to transiently open the blood-brain barrier and deliver a first-in-class liposome-loaded small molecule MGMT inactivator in mice bearing temozolomide-resistant gliomas. We demonstrate that a liposomal O-(4-bromothenyl)guanine (OBTG) derivative can efficiently target MGMT, thereby sensitizing murine and human glioma cells to temozolomide in vitro. Read More
J Anat 2018 Dec 9. Epub 2018 Dec 9.
Fraunhofer Institute for Machine Tools and Forming Technology IWU, Dresden, Germany.
The sacroiliac joint (SIJ) is a well-known source of low back and pelvic pain, of increasing interest for both conservative and surgical treatment. Alterations in the kinematics of the pelvis have been hypothesized as a major cause of SIJ-related pain. However, definitions of both the range and the extent of physiological movement are controversial, and there are no clear baseline data for pathological alterations. Read More
Oncogene 2018 Dec 7. Epub 2018 Dec 7.
Department of Medical Genetics, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China.
MDM2 (Murine double minute 2) acts as a key repressor for p53-mediated tumor-suppressor functions, which includes cellular senescence. We found that MDM2 can promote cellular senescence by modulating WRN stability. Werner syndrome (WS), caused by mutations of the WRN gene, is an autosomal recessive disease, which is characterized by premature aging. Read More
Hosp Pediatr 2018 Dec 10. Epub 2018 Dec 10.
Department of Pediatrics, School of Medicine and Public Health,
Objectives: Children with medical complexity (CMC) are commonly assisted by medical devices to support essential body functions, although complications may lead to preventable emergency department (ED) and hospital use. Our objective was to identify predictors of device-complicated ED visits and hospitalizations.
Methods: This single-center retrospective cohort study included patients referred to a Pediatric Complex Care Program between April 1, 2014, and April 30, 2016, assisted by at least 1 medical device. Read More
Biochem Pharmacol 2018 Dec 7. Epub 2018 Dec 7.
Cancer Target and Experimental Therapeutics, Institute for Advanced Biosciences, INSERM U1209, CNRS UMR5309, Grenoble Alpes University, Grenoble, France. Electronic address:
Standard chemotherapies that interfere with microtubule dynamics are a chemotherapeutic option used for the patients with advanced malignancies that invariably relapse after targeted therapies. However, major efforts are needed to reduce their toxicity, optimize their efficacy, and reduce cancer chemoresistance to these agents. We previously identified a pyrrolo[2,3d]pyrimidine-based microtubule-depolymerizing agent (PP-13) that binds to the colchicine site of β-tubulin and exhibits anticancer properties in solid human cancer cells, including chemoresistant subtypes. Read More
Parkinsonism Relat Disord 2018 Nov 29. Epub 2018 Nov 29.
Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands; GROW Research Institute for Oncology and Developmental Biology, Maastricht University, Maastricht, the Netherlands.
Background: The frequency of late-onset Huntington's disease (>59 years) is assumed to be low and the clinical course milder. However, previous literature on late-onset disease is scarce and inconclusive.
Objective: Our aim is to study clinical characteristics of late-onset compared to common-onset HD patients in a large cohort of HD patients from the Registry database. Read More
Curr Rheumatol Rev 2018 Dec 10. Epub 2018 Dec 10.
Department of Orthopedic Surgery, SUNY Upstate Medical University, Syracuse, New York. United States.
Background: Scapholunate interosseous ligament (SLIL) injury following a fall on an outstretched hand may lead to carpal instability and in some cases require long term rehabilitation following repair. Rehabilitation, especially in athletes, may include pushups, but little is known as to what type of pushup may be safer.
Objective: To determine biomechanical differences between two pushup position (neutral or extended). Read More
Radiology 2018 Dec 11:180946. Epub 2018 Dec 11.
From the Department of Diagnostic and Interventional Neuroradiology (H.C.K., T.S., U.H., M.H.S., J.F., S.G.), Department of Radiotherapy and Radiation Oncology (F.M., T.G.), Institute of Medical Biometry and Epidemiology (G.S.), and Institute of Computational Neuroscience (F.M., R.W.); University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
Purpose To investigate the feasibility of tumor type prediction with MRI radiomic image features of different brain metastases in a multiclass machine learning approach for patients with unknown primary lesion at the time of diagnosis. Materials and methods This single-center retrospective analysis included radiomic features of 658 brain metastases from T1-weighted contrast material-enhanced, T1-weighted nonenhanced, and fluid-attenuated inversion recovery (FLAIR) images in 189 patients (101 women, 88 men; mean age, 61 years; age range, 32-85 years). Images were acquired over a 9-year period (from September 2007 through December 2016) with different MRI units, reflecting heterogeneous image data. Read More
J Chem Phys 2018 Dec;149(21):215101
Department of Astronomy and Theoretical Physics, Lund University, Lund, Sweden.
Nanochannels provide a means for detailed experiments on the effect of confinement on biomacromolecules, such as DNA. Here we introduce a model for the complete unfolding of DNA from the circular to linear configuration. Two main ingredients are the entropic unfolding force and the friction coefficient for the unfolding process, and we describe the associated dynamics by a non-linear Langevin equation. Read More
J Am Acad Orthop Surg 2018 Dec 4. Epub 2018 Dec 4.
From the Department of Orthopaedic Surgery, University of Virginia, Charlottesville, VA.
Background: A few investigations exist which evaluate the influence of obstructive sleep apnea (OSA) on complications after arthroscopic rotator cuff repair.
Methods: A database was queried for patients undergoing rotator cuff repair with and without OSA and further subdivided into those with and without a billing code for a continuous positive airway pressure (CPAP) device. Thirty-day and 6-month adverse events were assessed. Read More
Curr Rheumatol Rev 2018 Dec 5. Epub 2018 Dec 5.
Department of Orthopedic Surgery, SUNY Upstate Medical University, Syracuse, NY. United States.
Morphology may provide the basis for the understanding of wrist mechanics. We used classification systems based on cadaver dissection of lunate and capitate types to evaluate a normal database of 70 wrist radiographs in 35 subjects looking for associations between bone shapes. Kappa statistics and a log-linear mixed -effects model with a random intercept were used. Read More
Nature 2018 Dec 5. Epub 2018 Dec 5.
Department of Anaesthesiology, University Hospital, LMU Munich, Munich, Germany.
Heart transplantation is the only cure for patients with terminal cardiac failure, but the supply of allogeneic donor organs falls far short of the clinical need. Xenotransplantation of genetically modified pig hearts has been discussed as a potential alternative. Genetically multi-modified pig hearts that lack galactose-α1,3-galactose epitopes (α1,3-galactosyltransferase knockout) and express a human membrane cofactor protein (CD46) and human thrombomodulin have survived for up to 945 days after heterotopic abdominal transplantation in baboons. Read More
JCI Insight 2018 Dec 6;3(23). Epub 2018 Dec 6.
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center (LUMC), Leiden, Netherlands.
PD-1/PD-L1 checkpoint therapy for cancer is commonly considered to act by reactivating T cells in the tumor microenvironment. Here, we present data from 2 mouse tumor models demonstrating an essential involvement of tumor-draining lymph nodes in PD-1 and PD-L1 therapeutic efficacy. Immune activation induced by checkpoint treatment was predominantly observed in the tumor-draining, but not nondraining, lymph nodes and was reflected in local accumulation of CD8+ T cells. Read More
Mar Drugs 2018 Dec 4;16(12). Epub 2018 Dec 4.
Institute for Inorganic and Analytical Chemistry, Bioorganic Analytics, Friedrich Schiller University Jena, Lessingstr. 8, D-07743 Jena, Germany.
Algicidal bacteria can lyse microalgal blooms and trigger shifts within plankton communities. Resistant algal species can escape lysis, and have the opportunity to dominate the phytoplankton after a bacterial infection. Despite their important function in ecosystem regulation, little is known about mechanisms of resistance. Read More
Mol Psychiatry 2018 Nov 30. Epub 2018 Nov 30.
Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Campus-Vienna-Biocenter 1, 1030, Vienna, Austria.
Benzodiazepines (BZDs) have been a standard treatment for anxiety disorders for decades, but the neuronal circuit interactions mediating their anxiolytic effect remain largely unknown. Here, we find that systemic BZDs modulate central amygdala (CEA) microcircuit activity to gate amygdala output. Combining connectome data with immediate early gene (IEG) activation maps, we identified the CEA as a primary site for diazepam (DZP) anxiolytic action. Read More
Dent Mater 2018 Nov 27. Epub 2018 Nov 27.
Department of Conservative Dentistry, Periodontology and Preventive Dentistry, Hannover Medical School, D-30625 Hannover, Germany. Electronic address:
Objective: Dental pulp stem cells (DPSCs) can differentiate into tissue specific lineages to support dental pulp regeneration after injuries. Triethylene glycol dimethacrylate (TEGDMA) is a widely used co-monomer in restorative dentistry with adverse effects on cellular metabolism. Aim of this study was to analyze the impact of TEGDMA on the angiogenic differentiation potential of DPSCs. Read More
Materials (Basel) 2018 Nov 29;11(12). Epub 2018 Nov 29.
Institute of Physics, Bijenička 46, 10000 Zagreb, Croatia.
For this study, a paper impregnated with silver nanoparticles (AgNPs) was prepared. To prepare the substrates, aqueous suspensions of pulp fines, a side product from the paper production, were mixed with AgNP suspensions. The nanoparticle (NP) synthesis was then carried out via laser ablation of pure Ag in water. Read More
Eur J Pharm Sci 2018 Dec 3;128:162-170. Epub 2018 Dec 3.
Life Science Technologies, Ostwestfalen-Lippe University of Applied Science, Georg-Weerth-Straße 20, 32756 Detmold, Germany.
The Process Analytical Technology (PAT) initiative published by the Food and Drug administration (FDA) describes PAT systems as important tools to optimize pharmaceutical processes in order to ensure the final product quality. Real-time particle size measurements provide a promising approach for process automation of fluid bed granulation processes. This work focuses on the introduction and evaluation of a new time-based buffer approach for in-line spatial filtering technique (SFT) in order to provide a minimum time delay of the real-time measurement. Read More
Phys Rev Lett 2018 Nov;121(21):211801
CERN, Geneva, Switzerland.
A combination of the searches for pair-produced vectorlike partners of the top and bottom quarks in various decay channels (T→Zt/Wb/Ht, B→Zb/Wt/Hb) is performed using 36.1 fb^{-1} of pp collision data at sqrt[s]=13 TeV with the ATLAS detector at the Large Hadron Collider. The observed data are found to be in good agreement with the standard model background prediction in all individual searches. Read More
Phys Rev Lett 2018 Nov;121(21):212301
CERN, Geneva, Switzerland.
This Letter presents a measurement of γγ→μ^{+}μ^{-} production in Pb+Pb collisions recorded by the ATLAS detector at the Large Hadron Collider at sqrt[s_{NN}]=5.02 TeV with an integrated luminosity of 0.49 nb^{-1}. Read More
Clin Nucl Med 2018 Dec 3. Epub 2018 Dec 3.
Gynecomastia is not uncommon in men older than 50 years of age and is characterized by glandular proliferation of breast tissue. Non-physiologic gynecomastia is mostly caused by a variety of external medical interventions. Medications that belong to classes of antiandrogens, antipsychotics, or antibiotics alter the levels of estrogen and testosterone and are commonly implicated in patients with gynecomastia. Read More
Ecology 2018 Dec 5. Epub 2018 Dec 5.
Department of Plant Sciences, University of California, Davis, CA, 95616.
Disturbance such as wildfire may create opportunities for plant communities to reorganize in response to climate change. The interaction between climate change and disturbance may be particularly important in forests, where many of the foundational plant species (trees) are long-lived and where poor initial tree establishment can result in conversion to shrub- or graminoid-dominated systems. The response of post-disturbance vegetation establishment to post-disturbance weather conditions-particularly to extreme weather-could therefore provide useful information about how forest communities will respond to climate change. Read More
Front Endocrinol (Lausanne) 2018 20;9:692. Epub 2018 Nov 20.
Department of Pharmacology, Physiology and Neuroscience and Cancer Center, Rutgers University, The State University of New Jersey, New Brunswick, NJ, United States.
Sci Rep 2018 Dec 4;8(1):17631. Epub 2018 Dec 4.
Department of Nuclear Medicine, University Hospital Wuerzburg, Wuerzburg, Germany.
In diabetic cardiomyopathy, left ventricular (LV) diastolic dysfunction is one of the earliest signs of cardiac involvement prior to the definitive development of heart failure (HF). We aimed to explore the LV diastolic function using electrocardiography (ECG)-gated F-fluorodeoxyglucose positron emission tomography (F-FDG PET) imaging beyond the assessment of cardiac glucose utilization in a diabetic rat model. ECG-gated F-FDG PET imaging was performed in a rat model of type 2 diabetes (ZDF fa/fa) and ZL control rats at age of 13 weeks (n = 6, respectively). Read More
NPJ Prim Care Respir Med 2018 Dec 4;28(1):45. Epub 2018 Dec 4.
Technical University of Munich, TUM School of Medicine, Institute of General Practice, Munich, Germany.
The Control of Allergic Rhinitis and Asthma Test (CARAT10), developed by Portuguese experts, is the only questionnaire assessing asthma control under additional consideration of a frequently concurrent allergic rhinitis (AR), providing sub-scores for both diseases. Aims of this study were the translation and validation of its German version. Asthma patients both with and without AR were included at three primary care pulmologists´ practices in Southern Germany. Read More
BMC Pharmacol Toxicol 2018 Dec 4;19(1):80. Epub 2018 Dec 4.
James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH, USA.
Background: Several tyrosine kinase inhibitors (TKIs) developed as anti-cancer drugs, also have anti-viral activity due to their ability to disrupt productive replication and dissemination in infected cells. Consequently, such drugs are attractive candidates for "repurposing" as anti-viral agents. However, clinical evaluation of therapeutics against infectious agents associated with high mortality, but low or infrequent incidence, is often unfeasible. Read More
Materials (Basel) 2018 Nov 30;11(12). Epub 2018 Nov 30.
Institute for Paper-, Pulp- and Fibre Technology, Graz University of Technology, Inffeldgasse 23, 8010 Graz, Austria.
This study investigates flexible (polyamide 6.6 PA-6.6, polyethylene terephthalate PET, Cu, Al, and Ni foils) and, for comparison, stiff substrates (silicon wafers and glass) differing in, for example, in surface free energy and surface roughness and their ability to host cellulose-based thin films. Read More
iScience 2018 Nov 20;10:123-134. Epub 2018 Nov 20.
Department of Evolutionary Biology, Max Planck Institute for Developmental Biology, Tübingen 72076, Germany. Electronic address:
Many animal and plant species respond to population density by phenotypic plasticity. To investigate if specific age classes and/or cross-generational signaling affect density-dependent plasticity, we developed a dye-based method to differentiate co-existing nematode populations. We applied this method to Pristionchus pacificus, which develops a predatory mouth form to exploit alternative resources and kill competitors in response to high population densities. Read More
Dev Cell 2018 Dec;47(5):535-536
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:
Cytokinesis is the subject of intense study, but mechanisms underlying contractility and cell shape change in cytokinesis are still being defined. Furthermore, it is unknown how contractile mechanisms vary among cell types and throughout development. Recent findings uncover differential molecular requirements for cytokinesis depending on cell fate and embryonic context. Read More
Anaesthesist 2018 Dec;67(12):936-949
Stabsstelle Klinische Mikrobiologie und Krankenhaushygiene, Klinikum der Universität München, Campus Großhadern, München, Deutschland.
In January 2018 the recent revision of the S2k guidelines on calculated parenteral initial treatment of bacterial diseases in adults-update 2018 (Editor: Paul Ehrlich Society for Chemotherapy, PEG) was realized. It is a helpful tool for the complex infectious disease setting in an intensive care unit. The present summary of the guidelines focuses on the topics of anti-infective agents, including new substances, pharmacokinetics and pharmacodynamics as well as on microbiology, resistance development and recommendations for calculated drug therapy in septic patients. Read More
Front Physiol 2018 19;9:1553. Epub 2018 Nov 19.
Charité-Universitätsmedizin Berlin, Institute of Physiology, Center for Space Medicine and Extreme Environments Berlin, Berlin, Germany.
Head-down-tilt bed rest (HDT) mimics the changes in hemodynamics and autonomic cardiovascular control induced by weightlessness. However, the time course and reciprocal interplay of these adaptations, and the effective exercise protocol as a countermeasure need further clarification. The overarching aim of this work (as part of a European Space Agency sponsored long-term bed rest study) was therefore to evaluate the time course of cardiovascular hemodynamics and autonomic control during prolonged HDT and to assess whether high-intensity, short-duration exercise could mitigate these effects. Read More
BMC Pregnancy Childbirth 2018 Dec 4;18(1):473. Epub 2018 Dec 4.
Research Group `FamiLe - Family Health in Life Course`, Witten and Osnabrück, Germany.
Background: From the individual perspective, security, which is essential to life quality, is characterised as an elementary human need that requires fulfilment. During the transition to parenthood, mothers and fathers are confronted with changes in physical and psychosocial processes that are accompanied by uncertainty and insecurity. Feelings of insecurity may have consequences affecting their pregnancy and childbirth experiences as well as their adaption to the parental role in the first weeks following childbirth. Read More
SLAS Technol 2018 Nov 30:2472630318812341. Epub 2018 Nov 30.
1 Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University, Tübingen, Germany.
Radiosynthesis of [1-C]acetate is well described in literature, but all syntheses either require adaptations in complex commercial synthesizers or rely on closed-source hardware and software control. Arduino microcontrollers are ideal for the compact, flexible, and inexpensive control of low-complexity hardware, making them particularly suited for radiochemistry where operation in space-limited shielded hot cells is mandatory. We established a [1-C]acetate radiosynthesis module for combination with a [C]MeI module available in almost every lab working with C. Read More
Biomacromolecules 2018 Nov 30. Epub 2018 Nov 30.
We report a novel method to prepare capsules, beads or open-cell materials from Pickering emulsions of monomers, stabilized by cellulose nanocrystals (CNCs) grafted with reactive Isobutyrate bromide moieties (CNC-Br). CNC-Br particles with different hydrophylic/hydrophobic balance at their surface were prepared, and subsequently used to stabilize direct (O/W), inverted (W/O), or double emulsions of Styrene or n-BuA. The different emulsions obtained were subsequently polymerized, by initiating an AGET-ATRP polymerization from the brominated particles surrounding the stabilized droplets. Read More
Angew Chem Int Ed Engl 2018 Nov 30. Epub 2018 Nov 30.
UNITED STATES.
Broadly useful chiroptical ee sensing remains challenging and typically involves carefully designed molecular receptors or supramolecular assemblies. Herein, we describe enantioselective sensing of 35 amino acids, amino phosphonic acids, hydroxy acids, amino alcohols and diamines with an auxiliary-free cobalt probe. Chiroptical analysis of the enantiomeric composition and concentration of minute sample amounts is achieved with high accuracy using earth-abundant cobalt salts and hydrogen peroxide as oxidant. Read More
Sci Rep 2018 Nov 29;8(1):17460. Epub 2018 Nov 29.
Boone Pickens School of Geology, Oklahoma State University, 105 Noble Research Centre, Stillwater, Oklahoma, 74078, USA.
Carbonate depositional systems related to groundwater upwelling are ubiquitous around the world and form ecologically and culturally important features of many landscapes. Spring carbonate deposits record past climatic and hydrological conditions. The reconstruction of past processes using spring carbonate proxies requires fundamental understanding of the factors that control their geometry. Read More
Colloids Surf B Biointerfaces 2018 Nov 16;174:451-458. Epub 2018 Nov 16.
Clinic of Operative Dentistry, Periodontology and Preventive Dentistry, University Hospital, Saarland University, Building 73, 66421 Homburg/Saar, Germany.
The proteinaceous pellicle layer, which develops upon contact with saliva on the surface of teeth, is important for the formation of oral biofilms and for the protection of teeth from abrasion and chemically induced erosion. Astringent food ingredients comprising polyphenols, cationic macromolecules, and multivalent metal salts are known to interact with the pellicle. However, astringent-induced changes in the physicochemical properties of the tooth-saliva interphase are not yet completely understood. Read More
Eur Heart J 2018 Nov 28. Epub 2018 Nov 28.
Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Liebigstr. 20, Leipzig, Germany.
Aims: It is unknown whether different training modalities exert differential cellular effects. Telomeres and telomere-associated proteins play a major role in cellular aging with implications for global health. This prospective training study examines the effects of endurance training, interval training (IT), and resistance training (RT) on telomerase activity and telomere length (TL). Read More
Eur Heart J 2018 Nov 27. Epub 2018 Nov 27.
Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Leipzig, Germany.
Endocr Connect 2018 Nov 1. Epub 2018 Nov 1.
M Niedziela, Department of Pediatric Endocrinology and Rheumatology, Poznan University of Medical Sciences, Poznan, Poland.
Objective: 46,XY differences and/or disorders of sex development (DSD) are clinically and genetically heterogeneous conditions. Although complete androgen insensitivity syndrome has a strong genotype-phenotype correlation, the other types of 46,XY DSD are less well-defined and thus the precise diagnosis is challenging. This study focused on comparing the relationship between clinical assessment and genetic findings in a cohort of well-phenotyped patients with 46,XY DSD. Read More
Chemphyschem 2018 Nov 29. Epub 2018 Nov 29.
Institute of Chemistry, ZIK HALOmem and Charles-Tanford-Protein Center, University of Halle, Kurt-Mothes-Str. 3a, 06120, Halle, Germany.
Dual-color Fluorescence Cross-Correlation Spectroscopy (dcFCCS) allows binding analysis of biomolecules. Combining cross- and autocorrelation amplitudes yields binding degrees and concentrations of bound and unbound species. However, non-ideal detection volume overlap reduces the cross-correlation, causing overestimation of the K . Read More
Nat Commun 2018 11 28;9(1):5045. Epub 2018 Nov 28.
Laboratoire de Physique Statistique, Département de physique de l'ENS, Ecole Normale Supérieure, PSL Research University, Université Paris Diderot, Sorbonne Paris Cité, Sorbonne Universités, UPMC Univ. Paris 06, CNRS, 75005, Paris, France.
Active matter has been much studied for its intriguing properties such as collective motion, motility-induced phase separation and giant fluctuations. However, it has remained unclear how the states of active materials connect with the equilibrium phases. For two-dimensional systems, this is also because the understanding of the liquid, hexatic, and solid equilibrium phases and their phase transitions is recent. Read More
PLoS One 2018 28;13(11):e0206666. Epub 2018 Nov 28.
Faculty of Business Administration and Economics, University of Passau, Passau, Germany.
Previous laboratory studies on the centipede game have found that subjects exhibit surprisingly high levels of cooperation. Across disciplines, it has recently been highlighted that these high levels of cooperation might be explained by "team reasoning", the willingness to think as a team rather than as an individual. We run an experiment with a standard centipede game as a baseline. Read More
Pathologe 2018 Nov 27. Epub 2018 Nov 27.
Department für Allgemein- und Viszeralchirurgie, Universitätsklinikum Freiburg, Freiburg, Deutschland.
Background: Pancreatic ductal adenocarcinoma (PDAC) is a disease with a poor prognosis. PDAC shows characteristic mutations within codon 12/13. Circulating tumor cells (CTC) detected in blood samples of patients with cancer are hypothesized as the means of systemic tumor spread. Read More
Nature 2018 Nov 27. Epub 2018 Nov 27.
Physics and Theoretical Divisions, Los Alamos National Laboratory, Los Alamos, NM, USA.
In this Letter, owing to a production error, the penultimate version of the PDF was published. The HTML version was always correct. The PDF has been corrected online. Read More
Neuron 2018 Dec 25;100(5):1224-1240.e13. Epub 2018 Oct 25.
Department of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tübingen, Germany; Department of Empirical Inference, Max Planck Institute for Intelligent Systems and Max Planck ETH Center for Learning Systems, Tübingen, Germany. Electronic address:
Hippocampal ripple oscillations likely support reactivation of memory traces that manifest themselves as temporally organized spiking of sparse neuronal ensembles. However, the network mechanisms concurring to achieve this function are largely unknown. We designed a multi-compartmental model of the CA3-CA1 subfields to generate biophysically realistic ripple dynamics from the cellular level to local field potentials. Read More