Imatinib mesylate use in refractory eosinophilic granulomatosis with polyangiitis: a literature review and a case report.
- Tatiana V Beketova,
- Mikhail Y Volkov,
- Evgeniy A Naryshkin,
- Tatiana M Novoselova,
- Evgeniy L Nasonov
Clin Rheumatol 2018 Mar 21. Epub 2018 Mar 21.
Department of Vascular Problems in Rheumatic Diseases, V.A. Nasonova Research Institute of Rheumatology, Kashirskoe shosse 34A, Moscow, Russian Federation, 115522.
Recent advances in pharmacology have greatly expanded the drug repertoire for treatment of anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis. Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare multisystemic disorder, a type of the ANCA-associated vasculitis. Important features of this disease are eosinophilia and anti-myeloperoxidase ANCA presence in around 30-70% of patients. Read More