8,219 results match your criteria Wegener Granulomatosis


Temporal and Cartographic Analyses of the Distribution within Spain of Mortality Due to Granulomatosis with Polyangiitis (1984⁻2016).

Int J Environ Res Public Health 2019 Apr 17;16(8). Epub 2019 Apr 17.

Institute of Rare Diseases Research (IIER), Instituto de Salud Carlos III, 28029 Madrid, Spain.

The aim is to conduct a descriptive, population-based study in order to assess temporal and spatial changes in mortality due to granulomatosis with polyangiitis (GPA) in Spain from 1984 to 2016. Mortality data were obtained from the Spanish Annual Death Registry. Deaths in which GPA was the underlying cause were selected using the 446. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijerph16081388DOI Listing

Does transbronchial lung cryobiopsy give useful information in asthmatic patients?

Multidiscip Respir Med 2019 8;14:12. Epub 2019 Apr 8.

Department of Thoracic Diseases, "GB. Morgagni" Hospital, Forlì, Italy.

Introduction: Lung biopsy in asthmatic patients is justified in case of atypical presentations of asthma, when other differential diagnoses, such as hypersensitivity pneumonitis or eosinophilic granulomatosis with polyangiitis, could be possible or for research purposes.

Aim: We aim to describe the utility and the safety of TBLC (transbronchial lung cryobiopsy) in asthmatic patients, providing data on the pathological changes occurring in the airways and in the lung parenchyma.

Methods: We reviewed asthmatic patients that underwent TBLC, that eventually had only a final diagnosis of asthma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40248-019-0176-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452509PMC
April 2019
1 Read

P-ANCA negative eosinophilic granulomatosis with polyangiitis.

Respir Med Case Rep 2019 28;27:100830. Epub 2019 Mar 28.

Department of Pathology, Southern Illinois University, Springfield, IL, USA.

Vasculitis refers to inflammation of the systemic vessels. Eosinophilic granulomatosis with polyangiitis (EGPA) is a medium and small vessel vasculitis characterized by hypereosinophilia, pulmonary infiltrates, difficult to treat asthma and polyneuropathies. Diagnosis can often be challenging. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.rmcr.2019.100830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446216PMC
March 2019
1 Read

Oral manifestations of granulomatosis with polyangiitis - Clinical and radiological assessment.

J Dent Sci 2019 Mar 27;14(1):54-60. Epub 2018 Nov 27.

2nd Department of Medicine, Jagiellonian University Medical College, Krakow, Poland.

Background/purpose: Granulomatosis with polyangiitis (GPA) is a type of primary systemic vasculitis associated with the presence of anti-neutrophil cytoplasmic antibodies (ANCA). GPA mainly affects medium and small vessels and may manifest in different organs, most commonly upper respiratory tract. Oral lesions occur in 6-13% of GPA patients and might be the first symptom observed by the patient. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S19917902183054
Publisher Site
http://dx.doi.org/10.1016/j.jds.2018.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445982PMC
March 2019
2 Reads

[Treatment of ANCA-associated vasculitides: Certainties and controversies].

Authors:
Benjamin Terrier

Nephrol Ther 2019 Apr;15 Suppl 1:S7-S12

Service de médecine interne, centre de références des maladies auto-immunes et systémiques rares, hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP), 24, rue du Faubourg-Saint-Jacques, 75014 Paris, France; Faculté de médecine, université Paris Descartes, 24, rue du Faubourg-Saint-Jacques, 75014 Paris, France. Electronic address:

Antineutrophil cytoplasm antibodies (ANCA)-associated vasculitides are necrotizing vasculitis affecting small blood vessels and include granulomatosis with polyangiitis (formerly Wegener's), microscopic polyangiitis and eosinophilic granulomatosis with polyangiitis (formerly Churg-Strauss syndrome). Diagnosis of ANCA-associated vasculitis is based on the clinical presentation, ANCA positivity directed against proteinase 3 or myeloperoxidase, and when possible on histological evidence of vasculitis. Evolution of ANCA-associated vasculitides without treatment leads constantly to death. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nephro.2019.02.008DOI Listing
April 2019
2 Reads

Outcomes of Nasal Septal Perforation Repair Using Combined Temporoparietal Fascia Graft and Polydioxanone Plate Construct.

JAMA Facial Plast Surg 2019 Apr 11. Epub 2019 Apr 11.

Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee.

Importance: Numerous techniques are used for septal perforation repair, yet success rates remain variable. Few studies have evaluated the effectiveness of interposition grafts of polydioxanone plates combined with a temporoparietal fascia graft for septal perforation repair.

Objective: To investigate and describe the use of interposition grafts of polydioxanone plates combined with a temporoparietal fascia graft for septal perforation repair and the expansion of this technique to patients with more challenging comorbidities, including granulomatosis with polyangiitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamafacial.2019.0020DOI Listing
April 2019
1 Read

A boy in his teens with large ulcerations of the head and neck.

Tidsskr Nor Laegeforen 2019 Apr 8;139(7). Epub 2019 Apr 8.

Background: Granulomatosis with polyangiitis (GPA), formerly known as Wegener's granulomatosis, has a predilection for the upper airways, lungs and kidneys. However, any other organ can be affected. Although cutaneous lesions are common, they have only rarely been reported as a primary manifestation of the disease. Read More

View Article

Download full-text PDF

Source
https://tidsskriftet.no/2019/04/noe-laere-av/gutt-i-tenarene
Publisher Site
http://dx.doi.org/10.4045/tidsskr.18.0647DOI Listing
April 2019
2 Reads

Head and Neck Manifestations of Granulomatosis with Polyangiitis: A Retrospective analysis of 19 Patients and Review of the Literature.

Int Arch Otorhinolaryngol 2019 Apr 1;23(2):165-171. Epub 2019 Mar 1.

Department of Otorhinolaryngology and Head and Neck Surgery, Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain.

Granulomatosis with Polyangiitis (GPA) is a small vessel vasculitis characterized by a necrositing granulomatous inflammation of the upper and lower respiratory tracts and focal/proliferative glomerulonephritis. In more than 70% of the cases, the presenting symptoms are head and neck manifestations that are often misdiagnosed as infectious or allergic in etiology.  The present study provides an analysis of head and neck manifestations in a series of patients diagnosed with GPA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0038-1675759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449134PMC
April 2019
1 Read

Non-squamous cell carcinoma diseases of the larynx: clinical and imaging findings.

Braz J Otorhinolaryngol 2019 Mar 16. Epub 2019 Mar 16.

Erciyes University Medical Faculty, Department of Radiology, Kayseri, Turkey.

Introduction: Squamous cell carcinoma is the most common laryngeal neoplasm and accounts for approximately 95% of all malignant neoplams of the larynx. However, various benign and malignant tumors and inflammatory diseases may affect the larynx.

Objective: The purpose of this study is to analyze the clinical and imaging findings of non-squamous cell neoplasms and inflammatory diseases of the larynx. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S18088694183022
Publisher Site
http://dx.doi.org/10.1016/j.bjorl.2019.02.003DOI Listing
March 2019
6 Reads

Remission Of Non-Infectious Anterior Scleritis: Incidence And Predictive Factors.

Am J Ophthalmol 2019 Apr 2. Epub 2019 Apr 2.

Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD; Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD.

Purpose: To assess how often non-infectious anterior scleritis remits and identify predictive factors.

Methods: Our retrospective cohort study at four ocular inflammation subspecialty centers collected data for each affected eye/patient at every visit from center inception (1978, 1978, 1984, 2005) until 2010. Remission was defined as inactivity of disease off all suppressive medications at all visits spanning at least three consecutive months or at all visits up to the last visit (to avoid censoring patients stopping follow-up after remission). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajo.2019.03.024DOI Listing
April 2019
1 Read

Aggressive spinal cord involvement in granulomatosis with polyangiitis.

Int J Rheum Dis 2019 Apr 4;22(4):756-758. Epub 2019 Apr 4.

Department of Neurology, Otto-von-Guericke University, Magdeburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1756-185X.13561DOI Listing
April 2019
2 Reads

18FDG PET for Detecting Renal Granulomatous Localization: Illustration of Granulomatosis With Polyangiitis and Sarcoidosis.

J Clin Rheumatol 2019 Apr 3. Epub 2019 Apr 3.

AP-HP, Sorbonne Université Hôpital Saint Antoine Service de Médecine Interne and Inflammation-Immunopathology-Biotherapy Department, Paris Service de Médecine Nucléaire Université Paris 13, Bobigny, France AP-HP, Sorbonne Université Hôpital Saint Antoine Service de Médecine Interne and Inflammation-Immunopathology-Biotherapy Department, Paris

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RHU.0000000000001003DOI Listing

Safety and Efficacy of Mepolizumab in Patients with Eosinophilic Granulomatosis with Polyangiitis.

Pulm Med 2019 3;2019:4376380. Epub 2019 Mar 3.

Regional Neurological Associates, New York, USA.

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare form of vasculitis disorder which involves multiple organ systems and is characterized by asthma, pulmonary infiltrates, sinusitis, neuropathy, and peripheral eosinophilia. It also has an effect on the heart, skin, kidneys, and gastrointestinal tract. Interlukin-5 (IL-5) is involved in maturation and activation of eosinophil, the production of which is increased in the EGPA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/4376380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421039PMC
March 2019
3 Reads

[Hypereosinophilic syndrome and other rheumatic diseases with hypereosinophilia].

Z Rheumatol 2019 Apr 1. Epub 2019 Apr 1.

Klinik für Innere Medizin I, Sektion Rheumatologie, Exzellenzzentrum Entzündungsmedizin, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 3, 24105, Kiel, Deutschland.

Among the eosinophilic diseases treated by rheumatologists other than eosinophilic granulomatosis with polyangiitis, there are further organ-related and systemic diseases with hypereosinophilia. Only the exact differential diagnostic demarcation of the diseases enables a pathogenetic oriented treatment. This article focuses on the hypereosinophilic syndromes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00393-019-0623-xDOI Listing
April 2019
3 Reads

Multiple Distinctive Demyelinating Lesions Caused by Eosinophilic Granulomatosis With Polyangiitis: Case Report and Literature Review.

Front Neurol 2019 11;10:213. Epub 2019 Mar 11.

Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Eosinophilic granulomatosis with polyangiitis (EGPA) is an extremely rare rheumatic immune disease characterized by vasculitis of small- and medium-sized blood vessels. Central nervous system (CNS) involvement frequently consists of cerebrovascular disease; a manifestation with multiple demyelinating lesions has never been reported in detail. This report describes a 38-year-old man, who presented with progressive memory deterioration and underwent microsurgery; EGPA was subsequently confirmed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fneur.2019.00213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423896PMC
March 2019
6 Reads

Anti-Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis Causes Aortic Valve Degeneration and Severe Aortic Regurgitation.

Am J Case Rep 2019 Apr 1;20:423-429. Epub 2019 Apr 1.

Department of Cardiology, Odense University Hospital, Odense, Denmark.

BACKGROUND Granulomatosis with polyangiitis (GPA)/Wegener's granulomatosis (WG) and eosinophilic granulomatosis with polyangiitis (EGPA)/Churg-Strauss' syndrome (CSS) are ANCA (antineutrophil cytoplasmic antibodies) associated vasculitides that can affect the heart, predominantly the myocardium. Valvular affection is rare and is described anecdotally. The purpose of this case report was to present aortic valve affection of an ANCA positive vasculitis. Read More

View Article

Download full-text PDF

Source
https://www.amjcaserep.com/abstract/index/idArt/912693
Publisher Site
http://dx.doi.org/10.12659/AJCR.912693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454581PMC
April 2019
5 Reads

Airway Biopsy Results From Patients With Suspected Granulomatosis With Polyangiitis (2005-2015): Clinicopathological Correlation and Proposal of an Algorithm to Improve Diagnosis.

Ann Otol Rhinol Laryngol 2019 Mar 29:3489419839092. Epub 2019 Mar 29.

1 Instituto Nacional de Enfermedades Respiratorias, Mexico, Mexico City, Mexico.

Objectives:: The aim of this study was to review the histologic diagnostic yield of airway biopsies with a suspected granulomatosis with polyangiitis (GPA) diagnosis at a single center devoted to respiratory diseases using previously published criteria. A secondary aim was to apply the algorithm proposed by the European Medicines Agency to determine whether more biopsies were confidently identified as having GPA diagnoses.

Methods:: From a total of 132 airway biopsies (2005-2015), 50 were randomly selected for second review by an expert pathologist, and previously published criteria were applied. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0003489419839092DOI Listing
March 2019
7 Reads

Tolerability and safety of long-term rituximab treatment in systemic inflammatory and autoimmune diseases.

Rheumatol Int 2019 Mar 28. Epub 2019 Mar 28.

Clinical Immunology Unit, Stavanger University Hospital, Stavanger, Norway.

Rituximab, an anti-CD20 monoclonal antibody causing selective B-cell depletion, is used for various systemic inflammatory and autoimmune diseases (SIADs). Long-term safety data on rituximab are limited. The objectives of this study were to evaluate the long-term safety and tolerability of rituximab treatment for SIADs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00296-019-04272-1DOI Listing
March 2019
1 Read

Extracutaneous involvement of pyoderma gangrenosum.

Arch Dermatol Res 2019 Mar 29. Epub 2019 Mar 29.

Department of Dermatology and OHSU Wound and Hyperbaric Medicine, Oregon Health and Science University, 3303 SW Bond Ave Center for Health and Healing Building 1, Suite 16, Portland, OR, 97239, USA.

Pyoderma Gangrenosum (PG) is an inflammatory neutrophilic dermatosis (ND) associated with underlying chronic inflammation and/or malignancy. Diagnosis remains to be challenging as a gold standard diagnostic test is lacking. Initial manifestations may include papules, vesicles, or pustules that subsequently develop into ulceration with features of undermining and violaceous borders. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00403-019-01912-1DOI Listing
March 2019
1 Read

[The 469th case: multiple cutaneous abscesses, pelvic mass, and lung cavities].

Zhonghua Nei Ke Za Zhi 2019 Apr;58(4):333-336

Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

A 28-year-old woman with multiple abscesses for 2 month and fever for 1 month was admitted in Peking Union Medical College Hospital. The skin abscesses gradually developed at skull, face, abdominal wall and pelvis. Laboratory examinations related to inflammatory reactions were strongly high including erythrocyte sedimentation rate 99 mm/1 h,C-reactive protein160. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.0578-1426.2019.04.021DOI Listing
April 2019
3 Reads

Anti-neutrophil cytoplasmic antibody-positive eosinophilic granulomatosis with polyangiitis: can it cause membranous nephropathy?

Scand J Rheumatol 2019 Mar 25:1-2. Epub 2019 Mar 25.

d Department of Internal Medicine Division of Rheumatology , Hennepin County Medical Center , Minneapolis , MN , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/03009742.2019.1580765DOI Listing
March 2019
2 Reads

No Differences in Nasal Tissue Inflammatory Cells and Adhesion Molecules (iCAM-1 and vCAM-1) Based on the Comparison of EGPA With Eosinophilic Chronic Sinusitis With Polyposis.

Am J Rhinol Allergy 2019 Mar 25:1945892419836819. Epub 2019 Mar 25.

1 Otolaryngology Section, Department of Neuroscience-DNS, Padova University, Padova, Italy.

Background: An example of aggressive eosinophilic polyposis can be found in eosinophilic granulomatosis with polyangiitis (EGPA). Intercellular adhesion molecule-1 (iCAM-1) and vascular cell adhesion molecule-1 (vCAM-1) play a part in mediating the recruitment and adhesion of leukocytes to the vessel wall, and their blood-to-tissue migration under inflammatory conditions.

Objective: This prospective study compared 3 groups-patients with a definite diagnosis EGPA, non-EGPA patients with phenotypic features suggestive of EGPA, and patients with non-eosinophilic nasal polyposis (controls)-in terms of nasal tissue histology, iCAM-1 and vCAM-1 expression, and blood inflammatory cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1945892419836819DOI Listing
March 2019
3 Reads

Childhood-onset Eosinophilic Granulomatosis with Polyangiitis with a Vulvar Granuloma: A Case Report and Review of the Literature.

J Pediatr Adolesc Gynecol 2019 Mar 20. Epub 2019 Mar 20.

Department of Obstetrics & Gynecology, Kaiser Permanente, Roseville, Northern California, 1600 Eureka Road, Building C, 3rd floor, Roseville, CA 95661. Electronic address:

Background: Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare multisystem necrotizing vasculitis associated with eosinophilia and extravascular granulomas classically involving the upper and lower airways. There have only been a few reported cases of gynecologic involvement in EGPA.

Case: We present an 8-year-old female diagnosed with EGPA with a vulvar granuloma in what is the first reported pediatric gynecologic manifestation of EGPA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpag.2019.03.002DOI Listing
March 2019
1 Read

Subglottic Stenosis in Granulomatosis With Polyangiitis.

Am J Med Sci 2019 Apr 12;357(4):e13-e14. Epub 2019 Jan 12.

Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical University, Asahikawa, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amjms.2019.01.005DOI Listing
April 2019
2 Reads

MYCYC: unravelling the long road ahead in ANCA-associated vasculitis.

Ann Rheum Dis 2019 Mar 20. Epub 2019 Mar 20.

Clinical Immunology and Rheumatology Services, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/annrheumdis-2019-215241DOI Listing
March 2019
1 Read

Response to: 'MYCYC, unravelling the long road ahead in ANCA-associated vasculitis' by Jain .

Ann Rheum Dis 2019 Mar 20. Epub 2019 Mar 20.

Department of Renal Medicine, Addenbrooke's Hospital, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/annrheumdis-2019-215254DOI Listing
March 2019
1 Read

Should nasal biopsy inevitably be performed for classifying granulomatosis with polyangiitis in patients with rhinosinusitis? A retrospective chart review study.

Rheumatol Int 2019 Mar 18. Epub 2019 Mar 18.

Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.

Nasal biopsy is the essential method for differentiating and diagnosing granulomatosis with polyangiitis (GPA) in patients with chronic rhinosinusitis. Nevertheless, in the real clinical settings, there are several cases unable for nasal biopsy. Hence, in this study, we investigated initial clinical manifestations and laboratory factors which could be helpful for diagnosing GPA in cases unable for nasal biopsy performance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00296-019-04282-zDOI Listing
March 2019
1 Read

Orbital mass in ANCA-associated vasculitides: data on clinical, biological, radiological and histological presentation, therapeutic management, and outcome from 59 patients.

Rheumatology (Oxford) 2019 Mar 18. Epub 2019 Mar 18.

Department of Internal Medicine, National Referral Center for Systemic and Autoimmune Diseases, Hôpital de la Pitié-Salpêtrière, Paris.

Objective: Orbital mass is a rare and sight-threatening manifestation of ANCA-associated vasculitides, which remains a therapeutic challenge. We aimed to describe the presentation, therapeutic management and outcome of ANCA-associated vasculitides-related orbital mass.

Methods: We conducted a French nationwide retrospective study of patients with orbital mass in the setting of ANCA-associated vasculitides according to ACR criteria and/or Chapel Hill Consensus Conference definitions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/rheumatology/kez071DOI Listing
March 2019
1 Read
4.475 Impact Factor

Eosinophils in anti-neutrophil cytoplasmic antibody associated vasculitis.

BMC Rheumatol 2019 8;3. Epub 2019 Mar 8.

2Department of Hematology, Skane University Hospital and Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden.

Background: Anti-neutrophil cytoplasmic antibodies associated vasculitides (AAV) are characterized by autoimmune small vessel inflammation. Eosinophils are multifunctional cells with both pro-inflammatory and immunoregulatory properties. Tissue activated eosinophils secrete cyto- and chemokines and form extracellular traps (EETs), they release free granules and produce reactive oxygen species. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s41927-019-0059-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408823PMC
March 2019
1 Read

Ocular Manifestations of Granulomatosis with Polyangiitis: A Review of the Literature.

Ophthalmol Ther 2019 Mar 15. Epub 2019 Mar 15.

2nd Department of Ophthalmology, National and Kapodistrian University of Athens, Athens, Greece.

Granulomatosis with polyangiitis (GPA) is a rare systemic autoimmune disease of unknown etiology that is characterized by granulomatous inflammation, tissue necrosis, and vasculitis in small- and medium-sized vessels. Ocular and orbital manifestations are common in almost half of patients with GPA, affecting every structure of the eye, from the eyelid and orbit to the retina, the choroid, and the optic nerve, with a wide range of severity. Since imaging findings are not always specific for the diagnosis of GPA, biopsy is useful to confirm the diagnosis. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s40123-019-0176-8
Publisher Site
http://dx.doi.org/10.1007/s40123-019-0176-8DOI Listing
March 2019
14 Reads

Systemic vasculitis involving the breast: a case report and literature review.

Rheumatol Int 2019 Mar 14. Epub 2019 Mar 14.

Department of Rheumatology and Immunology, Peking University Third Hospital, No. 49, North Garden Road, Beijing, 100191, China.

Systemic vasculitis involving the breast is a rare clinical condition and may mimic breast cancer or mastitis clinically or radiographically. Here, we report a case of polyarteritis nodosa (PAN) with breast involvement and perform a literature review of published cases of systemic vasculitis affecting the breast to better understand this disorder. We report a case of PAN affecting the right breast in a young woman. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00296-019-04279-8
Publisher Site
http://dx.doi.org/10.1007/s00296-019-04279-8DOI Listing
March 2019
4 Reads

Granulomatosis with polyangiitis in a patient with biopsy-proven IgG4-related pulmonary disease and coincident small cell lung cancer.

BMJ Case Rep 2019 Mar 14;12(3). Epub 2019 Mar 14.

Rheumatology (111R), Minneapolis VA HCS, Minneapolis, Minnesota, USA.

Granulomatosis with polyangiitis (GPA) was diagnosed in a patient with a 16-month history of IgG4-related lung disease that spontaneously became asymptomatic. Cytoplasmic antineutrophil cytoplasmic antibody (ANCA) was positive at the time of diagnosis of IgG4-related disease (IgG4-RD), but there was no vasculitis or kidney disease. Sixteen months later he developed rapidly progressive glomerulonephritis that responded to cyclophosphamide treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2018-226280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424371PMC
March 2019
3 Reads

For Whom the Bell's Toll: Recurrent Facial Nerve Paralysis, A Retrospective Study and Systematic Review of the Literature.

Otol Neurotol 2019 Apr;40(4):517-528

Department of Otorhinolaryngology.

Purpose: To examine the etiology, clinical course, and management of recurrent peripheral facial nerve paralysis.

Methods: Retrospective review at a single tertiary academic center and systematic review of the literature. Clinical presentation, laboratory and imaging findings, treatment and outcome for all cases of recurrent ipsilateral, recurrent contralateral, and bilateral simultaneous cases of facial paralysis are reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MAO.0000000000002167DOI Listing
April 2019
9 Reads

Ocular involvement in granulomatosis with polyangiitis: A single-center cohort study on 63 patients.

Autoimmun Rev 2019 May 4;18(5):493-500. Epub 2019 Mar 4.

National Referral Center for Rare Systemic Autoimmune Diseases, Department of Internal Medicine, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France. Electronic address:

Objective: To analyse the ocular manifestations of patients with GPA, their treatment and outcome.

Methods: Retrospective cohort study performed at the National Referral Center for Vasculitis, Cochin Hospital, Paris (France), from January 2005 to December 2015. Among 308 patients with a new diagnosis of GPA in accordance with the American College of Rheumatology classification criteria and/or revised Chapel Hill nomenclature definitions, we identified those with ocular involvement and a subsequent follow up in our center. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15689972193005
Publisher Site
http://dx.doi.org/10.1016/j.autrev.2019.03.001DOI Listing
May 2019
7 Reads

Comment on: A case of granulomatosis with polyangiitis complicated by two opportunistic infections.

Int J Rheum Dis 2019 Apr 5;22(4):752. Epub 2019 Mar 5.

Faculty of Medicine, Department of Microbiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1756-185X.13528DOI Listing
April 2019
3 Reads

For Whom the Bell's Toll: Recurrent Facial Nerve Paralysis, A Retrospective Study and Systematic Review of the Literature.

Otol Neurotol 2019 Feb 27. Epub 2019 Feb 27.

Department of Otorhinolaryngology.

Purpose: To examine the etiology, clinical course, and management of recurrent peripheral facial nerve paralysis.

Methods: Retrospective review at a single tertiary academic center and systematic review of the literature. Clinical presentation, laboratory and imaging findings, treatment and outcome for all cases of recurrent ipsilateral, recurrent contralateral, and bilateral simultaneous cases of facial paralysis are reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MAO.0000000000002167DOI Listing
February 2019
1 Read

Limited GPA and Alpha-1 Antitrypsin Deficiency in a Pediatric Patient.

J Rheumatol 2019 Mar 1. Epub 2019 Mar 1.

From the Department of Family Medicine, University of Toronto, Toronto; Division of Gastroenterology and Nutrition, Division of Rheumatology, McMaster Children's Hospital; Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. Address correspondence to Dr. M. Batthish, Division of Rheumatology, Department of Pediatrics, McMaster University, 1280 Main St. West, L8N 3Z5, Canada. E-mail:

Granulomatosis with polyangiitis (GPA) is a rare systemic vasculitis affecting small to medium-sized blood vessels. The most frequent presenting symptoms are nonspecific constitutional symptoms, followed by pulmonary, renal, and upper respiratory tract symptoms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3899/jrheum.180979DOI Listing
March 2019
4 Reads

Clinical impact of alpha-1-antitrypsin deficiency in ANCA-associated vasculitis: results from a French retrospective monocentric cohort of 142 consecutive patients.

J Rheumatol 2019 03 1. Epub 2019 Mar 1.

From the Department of Internal Medicine, Department of Biochemistry, Department of Immunology & Department of Nephrology, CHU de Caen, Caen, F-14000, France; Department of Infectious Diseases, CH Mémorial,Saint-Lô, 50000, France. Address correspondence to Pr Achille AOUBA, Department of Internal Medicine and Clinical Immunology, CHU Côte de Nacre - Université Basse Normandie, Avenue de la Côte de Nacre, 14000 CAEN, FRANCE. Email:

Objective: Deficiency in alpha-1-antitrypsin (AAT) is a possible pathogenic cofactor in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). However, the clinical impact of AAT deficiency remains poorly established in this setting. This study aimed to describe the clinical phenotypes and outcomes of AAV according to AAT phenotypes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3899/jrheum.180591DOI Listing
March 2019
1 Read

'Carpal tunnel syndrome' and 'tennis elbow' as prodromes for granulomatosis with polyangiitis (formerly Wegener's granulomatosis).

BMJ Case Rep 2019 Feb 28;12(2). Epub 2019 Feb 28.

Division of Rheumatology, Columbia University, New York, New York, USA.

A 62-year-old man presented with excruciating joint pains, back stiffness and numbness of his hands and feet. Over the past 18 months, he had experienced similar episodes for which the diagnoses of bilateral carpal tunnel syndrome and lateral epicondylitis had been made. Physical examination revealed polyarticular arthritis affecting the shoulders, wrists and right knee. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2018-227348DOI Listing
February 2019
3 Reads

Hypophysis Involvement in Granulomatosis with Polyangiitis.

Arthritis Rheumatol 2019 Feb 28. Epub 2019 Feb 28.

Dokuz Eylul University School of Medicine, Department of Rheumatology, Izmir, Turkey.

A 25-year-old, previously healthy female presented with a 3 months history of new-onset headache, polyuria and polydipsia. There was no infection, trauma, or drug intake prior symptoms. Physical examination was unremarkable; laboratory tests were consistent with increased inflammation markers along with hypernatremia, high serum osmolality, and low urine osmolality. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/art.40873DOI Listing
February 2019
1 Read

Clinical impact of subgrouping ANCA-associated vasculitis according to antibody specificity beyond the clinicopathological classification.

Rheumatology (Oxford) 2019 Feb 25. Epub 2019 Feb 25.

Department of Internal Medicine and Clinical Immunology, Normandie Univ, UNICAEN, CHU de Caen Normandie, Caen, France.

Objectives: In ANCA-associated vasculitis (AAV), classifications have emerged to individualize homogeneous clinical and outcomes patterns, including the recently defined anti-MPO granulomatosis with polyangiitis (GPA) subgroup. This study aimed to retrospectively evaluate the impacts of re-classification based on clinicopathological criteria and/or ANCA specificity.

Methods: A retrospective monocentric study conducted at Caen University Hospital led to the identification of PR3 or MPO-ANCA AAV patients from January 2000 or September 2011, respectively, to June 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/rheumatology/kez016DOI Listing
February 2019
1 Read

Echocardiogram: The GPS to GPA's Heart (Granulomatosis with Polyangiitis).

Case Rep Rheumatol 2019 16;2019:7609386. Epub 2019 Jan 16.

Robert Wood Johnson Medical School, Piscataway Township, NJ, USA.

Granulomatosis with polyangiitis (GPA) is a rare ANCA-associated necrotizing granulomatous vasculitis affecting small- to medium-sized vessels. Common manifestations of this disease process affect the ear, nose, throat, upper and lower airways, and kidneys. Cardiac involvement has been reported in 6-44% of patients, primarily as coronary arteritis and pericarditis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/7609386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360069PMC
January 2019
2 Reads

Chronic pulmonary aspergillosis may cause eosinophilic granulomatosis with polyangiitis via allergic bronchopulmonary aspergillosis.

Oxf Med Case Reports 2019 Feb 16;2019(2):omy126. Epub 2019 Feb 16.

Second Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.

An 84-year-old man visited our hospital with a prolonged productive cough. Chest computed tomography showed a thick wall cavity and bilateral consolidations. Laboratory findings revealed peripheral blood eosinophilia, increased total IgE and elevated myeloperoxidase anti-neutrophil cytoplasmic antibody. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/omcr/omy126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380532PMC
February 2019
2 Reads

Rare presentation of granulomatosis with polyangiitis.

BMJ Case Rep 2019 Feb 22;12(2). Epub 2019 Feb 22.

Department of Internal Medicine, New York-Presbyterian/Queens, Flushing, New York, USA.

A 62-year-old man with no pertinent medical history presented with lower extremity weakness and worsening distal fingertips and toe cyanosis/gangrene. In the outpatient setting, he was initially being treated for Raynaud's phenomenon with a calcium channel blocker. On presentation, the patient had elevated inflammatory markers and white blood cell count. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2018-227218DOI Listing
February 2019
3 Reads

Rituximab as an effective and probably safe treatment for granulomatosis with polyangiitis (Wegener's Granulomatosis).

Int Immunopharmacol 2019 May 20;70:67-68. Epub 2019 Feb 20.

Rheumatology and Internal Medicine, Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.01.029DOI Listing
May 2019
1 Read

Anemia Combined Significantly Increased High-Sensitivity C Reactive Protein and Lung Lesions Lead to the Diagnosis of Granulomatosis with Polyangiitis Proven by Lung Biopsy and Anti-neutrophil Cytoplasmic Antibody Test.

Clin Lab 2019 Jan;65(1)

Background: To report an atypical case misdiagnosed as lung abscess over the past 2 months, but persistent anemia combined with significantly increased hs-CRP and lung lesions indicated systemic lesion, which led to the diagnosis of granulomatosis with polyangiitis proven by lung biopsy and anti-neutrophil cytoplasmic antibody test (ANCA).

Methods: The complete blood count, hs-CRP, and anti-neutrophil cytoplasmic antibody (ANCA) test were performed. The pathology consultation for the lung biopsy was arranged. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7754/Clin.Lab.2018.180733DOI Listing
January 2019
2 Reads
1.084 Impact Factor

Granulomatosis With Polyangiitis Induced by Infection.

Kidney Int Rep 2019 Feb 26;4(2):341-345. Epub 2018 Sep 26.

Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ekir.2018.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365307PMC
February 2019
1 Read