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Semin Oncol Nurs 2022 May 13:151284. Epub 2022 May 13.

Department of Urology, University Hospitals Leuven, Leuven, Belgium. Electronic address:

Objectives: Human papillomavirus (HPV) is the most common sexually transmitted infection globally, which causes nearly all cervix carcinomas and contributes to oropharyngeal, penile, vulva, vagina, and anal cancers. Despite the role of HPV in several preneoplastic and cancerous lesions in men, male vaccine coverage is low. This article aims to provide insights into the pathophysiology of HPV-related penile cancer and penile intraepithelial neoplasia (PeIN). Read More

Vaccine 2022 May 11. Epub 2022 May 11.

Consulta de Doenças Sexualmente Transmissíveis, Centro de Saúde da Lapa, R. de São Ciro 36, 1200-830 Lisboa, Portugal.

Int J Mol Sci 2022 Apr 20;23(9). Epub 2022 Apr 20.

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR-1163, Necker Hospital for Sick Children, 75015 Paris, France.

Giant condyloma acuminatum, also known as Buschke-Lowenstein tumor (BLT), is a rare disease of the anogenital region. BLT is considered a locally aggressive tumor of benign histological appearance, but with the potential for destructive growth and high recurrence rates. BLT development is strongly associated with infection with low-risk human papillomaviruses (HPVs), mostly HPV-6 and -11. Read More

Eur J Health Econ 2022 May 13. Epub 2022 May 13.

Institute for Leadership and Management in Health, Kingston University, London, UK.

Background And Objective: HPV (human papillomavirus) is the virus most often responsible for sexually transmitted infections. The burden of HPV-related diseases on hospital resources represents a major public health problem. The objective of this study was to quantify the lifetime economic burden of HPV-related diseases based on hospital resources from the perspective of National Health Service (NHS) in England. Read More

Arch Gynecol Obstet 2022 May 13. Epub 2022 May 13.

EACCOS Research Group, Universidad Autónoma de Madrid, Madrid, Spain.

Purpose: The HPV-Quality-of-Life (HPV-QoL) questionnaire was developed to determine the impact of Human-Papillomavirus (HPV) infection and related interventions on women health-related quality-of-life. This study provides the development and preliminary psychometric properties of a novel HPV-QoL questionnaire for adult women with HPV.

Methods: After reviewing literature and cognitive debriefing interviews in women who had experienced HPV-related conditions, instrument items and domains were developed. Read More

Sex Transm Infect 2022 May 6. Epub 2022 May 6.

Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Z Evid Fortbild Qual Gesundhwes 2022 Apr 27. Epub 2022 Apr 27.

Stabsstelle Krebsprävention, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Deutschland. Electronic address:

Background: In Germany, the prevalence of infections with the human papilloma virus (HPV) among women and men is high. High-risk HPV types can lead to certain types of cancer (e. g. Read More

Reprod Health 2022 Apr 27;19(1):102. Epub 2022 Apr 27.

Department of Midwifery, School of Nursing and Midwifery, Community Based Psychiatric Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Human papillomavirus is the most common sexually transmitted infection, usually passing from one person to another after the first sexual activity. Infection with this virus and the occurrence of genital warts (GWs) could have several effects on patients' health. This study was performed to evaluate the sexual function and sexual quality of life (SQOL) in men with GWs. Read More

Cureus 2022 Mar 25;14(3):e23477. Epub 2022 Mar 25.

Emergency Medicine, Envision Physician Services, Plantation, USA.

The Buschke-Löwenstein tumor (BLT), also known as giant condylomata acuminata (GCA), is a pseudo-epithelial proliferation engendered by the human papillomavirus (HPV). Interestingly, its location at the anal margin, or perianal skin, is rare. The authors present the case of a gentleman who became unstable while standing, stating that his ears were ringing. Read More

Viruses 2022 Apr 5;14(4). Epub 2022 Apr 5.

Division of Cancer Sciences, University of Manchester, Oxford Rd, Manchester M13 9WL, UK.

Vaccination programs with the current prophylactic HPV vaccines started in most countries around 2008 with introduction of the bivalent Cervarix HPV16/18 vaccine, rapidly followed by Gardasil (HPV6/11/16/18) and, finally, Gardasil 9 (HPV6/11/16/18/31/33/45/52/58), from 2015. Many studies have now confirmed their ability to prevent infection with vaccine-covered HPV types, and the subsequent development of either genital warts and/or cervical neoplasia, although this is clearly more effective in younger women vaccinated prior to sexual debut. Most notably, reductions in the prevalence of vaccine-covered HPV types were also observed in unvaccinated women at the same geographical location, presumably by sexual dissemination of these changes, between vaccinated and unvaccinated women. Read More

Vaccines (Basel) 2022 Apr 13;10(4). Epub 2022 Apr 13.

Division of Infectious Diseases, St. Mary's General Hospital, Passaic, NJ 07055, USA.

Human papillomavirus (HPV) is the most common sexually transmitted infection in the United States (US). It is often discussed within the context of women's sexual health due to its association with cervical cancer. However, HPV is also associated with other cancers and conditions which affect men. Read More

Infect Agent Cancer 2022 Apr 21;17(1):19. Epub 2022 Apr 21.

Department of Clinical Laboratory, Minzu Hospital of Guangxi Zhuang Autonomous Region, Affiliated Minzu Hospital of Guangxi Medical University, Nanning, 530001, Guangxi Zhuang Autonomous Region, China.

Background: Human papillomavirus is a primary cause of cervical cancer and genital warts. HPV vaccine can prevent high-grade cervical lesions as well as cervical cancer. The aim of this study was to analyze the prevalence and genotype distribution of human papillomavirus among women in Guangxi before and after the HPV vaccine was approved for use in China. Read More

Clin Infect Dis 2022 Apr 19. Epub 2022 Apr 19.

Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.

Background: Kidney transplant recipients (KTRs) have increased risk of human papillomavirus (HPV)-related anogenital (pre-)cancers, including anal high-grade intraepithelial lesions (HSIL) and cancer. Previous studies on anal high-risk HPV among KTRs are sparse.

Methods: In a cross-sectional study, we included 247 KTRs and 248 controls from a dermatology department and five nephrology departments in Denmark during 2016-2017. Read More

JMIR Form Res 2022 Apr 11;6(4):e28676. Epub 2022 Apr 11.

Department of Communication, University of Illinois at Urbana, Urbana, IL, United States.

Background: Human papillomavirus (HPV) can cause several types of cancers and genital warts. A vaccine is available to prevent HPV infections, and several efforts have been made to increase HPV education and, eventually, vaccination. Although previous studies have focused on the development of messages to educate children about HPV and the existence of the HPV vaccine, limited research is available on how to help children better communicate with their parents and health care professionals about the HPV vaccination. Read More

New Microbiol 2022 Jan 11;45(1):73-81. Epub 2021 Dec 11.

Translational Medicine, Vanguard and Technology Transfer Sector, Human Health Department, Central ADN Laboratories. Morelia, Michoacán, México, 58341.

The distribution of Human Papilloma Virus (HPV) genotypes is not homogeneous among the infectedcells in a specific anatomical site. Thus, we conducted a prospective cross-sectional studywith 2,130 Mexican men and women aged 16 to 80 years. We described the prevalence of HPVgenotypes at the oropharyngeal cavity, anus, and urogenital sites. Read More

PeerJ 2022 23;10:e13140. Epub 2022 Mar 23.

Department of Clinical Pharmacy, College of Pharmacy, University of Hail, Hail, Saudi Arabia.

Background: Human papillomavirus (HPV) is a well-known cause of cervical cancer. The prevalence of HPV, insufficient preventive services, inadequate treatment access, socioeconomic conditions, certain cultural causes and values and opinions regarding cervical cancer have been established as factors contributing to the occurrence of cervical cancer in various parts of the world.

Objective: To determine university students' knowledge, attitudes and perceptions regarding HPV and its vaccine. Read More

J Infect Chemother 2022 Jul 25;28(7):845-852. Epub 2022 Mar 25.

Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

The present guidelines aim to provide comprehensive information on genital condyloma acuminata, including the epidemiology, clinical features, diagnosis and management. The guidelines provide evidence-based recommendations on the diagnosis, prevention and treatment of genital condyloma acuminata in adults in Asia, including patients with HIV co-infection.

Methodology: A PubMed search was performed, using the keywords "condyloma acuminata", "anal wart", "anogenital wart", "genital wart" and "genital HPV". Read More

United European Gastroenterol J 2022 Apr 23;10(3):249-250. Epub 2022 Mar 23.

Department of Gastroenterology, Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP, Hôpital Saint-Antoine, Paris, France.

BMC Infect Dis 2022 Mar 22;22(1):278. Epub 2022 Mar 22.

Department of Gynecology and Obstetrics, Medical Faculty, Birjand University of Medical Sciences, Birjand, Iran.

Background: Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide, affecting about 80% of women up to the age of 50. The persistent infection of high risk-HPV types (HR-HPV) is the leading cause of cervical cancer, the fourth most common cancer of women. Therefore, we aimed to evaluate the frequency and typing of HPV in the genital lesions in the Iranian population. Read More

J Med Case Rep 2022 Mar 18;16(1):116. Epub 2022 Mar 18.

Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon.

Background: Buschke-Löwenstein tumor is a giant condyloma acuminata infection that is characterized by degeneration, invasion, and recurrence. It is associated with human papilloma virus infection. It develops around the genital and perineal area, sometimes causing a large budding ulcerated lesion. Read More

J Obstet Gynaecol Can 2022 Mar;44(3):294-297

Allan Blair Cancer Centre, Regina, SK.

Giant condyloma acuminatum (GCA) is a benign anogenital lesion caused by human papilloma virus. It is rarely found on the cervix and is difficult to differentiate from malignancy. It is associated with a propensity for invasion, recurrence, and malignant transformation. Read More

United European Gastroenterol J 2022 Apr 16;10(3):287-295. Epub 2022 Mar 16.

PREDICT, Center for Molecular Prediction of Inflammatory Bowel Disease, Faculty of Medicine, Aalborg University, Copenhagen, Denmark.

Background: Patients with inflammatory bowel disease (IBD) are at increased risk of human papillomavirus (HPV) related cancers such as anal squamous cell carcinoma. However, risk of non-malignant HPV infection has never been systematically studied in IBD. This study aims to assess the risk of genital warts (GW) in IBD patients. Read More

Ann Coloproctol 2022 Mar 17. Epub 2022 Mar 17.

Department of Surgery, Tokatsu-Tsujinaka Hospital, Abiko, Japan.

Purpose: The anatomical distribution of perianal warts is associated with patient characteristics such as sexual orientation. The purpose of this study is to confirm this experiential knowledge using a quantitative classification system and analysis and to obtain findings useful for future treatment.

Methods: From January 2014 to December 2020, 93 patients with perianal warts presented to our hospital. Read More

Clin Drug Investig 2022 Apr 16;42(4):333-343. Epub 2022 Mar 16.

Fifth Department of Medicine, University Hospital Mannheim, Heidelberg University, Mannheim, Germany.

Background And Objectives: In South Africa, the prevalence of human papillomavirus (HPV) and associated diseases, such as cervical cancer and genital warts, is among the highest in the world. This study evaluates the cost-effectiveness of bivalent, quadrivalent, and nonavalent HPV vaccination for 9- to 14-year-old girls from the South African healthcare system perspective.

Methods: A Markov model portraying the natural HPV disease progression from high-risk infection to cervical intraepithelial neoplasia (CIN) I, CIN II/III, or cervical cancer and from low-risk infection to genital warts was built. Read More

Res Pharm Sci 2022 Apr 15;17(2):189-208. Epub 2022 Jan 15.

Department of Medicinal Chemistry, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, I.R. Iran.

Background And Purpose: Human papillomavirus (HPV) is known as the main reason for cervical cancer. According to carcinogenic risk, HPV can be located into two classes, counting the low-risk virus, which is the main cause of genital warts and low-grade cervical epithelial lesions. HPV-16 is one of the high-risk HPV subtypes in the spectrum of cervical diseases. Read More

Front Public Health 2022 21;10:774767. Epub 2022 Feb 21.

School of Health Management, Harbin Medical University, Harbin, China.

Human papillomavirus (HPV) is the most common genital tract virus infection and can cause genital warts and cervical cancer. This multicenter study examined HPV information sources, vaccine hesitancy, and the association between the two variables. An online survey of HPV information sources and vaccine hesitancy was conducted among Chinese medical students. Read More

BMC Womens Health 2022 03 8;22(1):63. Epub 2022 Mar 8.

Social Determinants in Health Promotion Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

Background: Genital wart (GW) is known as an infectious disease. Besides the infection, it is associated with a higher risk of cervical neoplasia and cancer in the infected population. The present research aimed to explore the predictors of GW preventive behaviors based on the health belief model (HBM). Read More

Actas Dermosifiliogr 2022 Feb;113(2):T115-T122

Servicio de Dermatología Medicoquirúrgica y Venereología, Hospital Universitario La Paz, Madrid, Spain.

Objective: To describe changes in sexually transmitted infection (STI) diagnoses during the first wave of the COVID-19 pandemic in Spain.

Material And Methods: We collected demographic, chronological, and clinical data for all patients seen for a possible STI at Hospital La Paz, Centro Sanitario Sandaval, and Centro de Diagnóstico Médico in Madrid and Hospital Costa del Sol in Malaga between March 14, 2020 and June 30, 2020.

Results: We identified 674 STI diagnoses. Read More

J Health Econ Outcomes Res 2022 7;9(1):31-38. Epub 2022 Feb 7.

Center for Observational and Real-world Evidence, Merck Sharp & Dohme, Madrid, Spain.

Cervical cancer rates in North Africa have risen in the last 10 years, suggesting that this region might benefit from cervical cancer screening and HPV vaccination programs. To assess the potential benefits of cervical cancer screening and HPV vaccination in North African countries, country-specific data on the prevalence and burden of HPV-related conditions are needed. To describe the patterns and estimate the costs of management of cervical cancer, cervical intraepithelial neoplasia (CIN), and genital warts in Algeria. Read More

Indian Dermatol Online J 2022 Jan-Feb;13(1):167-171. Epub 2022 Jan 24.

Department of Dermatology, Venereology and Leprosy, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.

Podophyllin is a cytotoxic material extracted from and and is widely used for the treatment of genital warts. This article reviews the chemistry of podophyllin and its active components along with the mechanism of action in various dermatoses. Furthermore, the documented uses of podophyllin in various dermatological disorders have been described along with the side effects of the drug. Read More