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Indian Dermatol Online J 2018 Nov-Dec;9(6):389-393

Department of Dermatology, Venereology and Leprosy, RNT Medical College, Udaipur, Rajasthan, India.

Background: Recently, with better understanding of the immunology of warts, immunotherapeutic approaches have emerged as an effective treatment option for the management of cutaneous warts. Intralesional immunotherapy with MMR vaccine is one such modality but there are still lack of enough placebo-controlled studies.

Aim: To evaluate the efficacy of intralesional MMR in patients of extragenital warts in a double-blinded manner using normal saline as control. Read More

Int J Surg Case Rep 2018 Nov 27;54:7-9. Epub 2018 Nov 27.

Department of Plastic Surgery and Breast Surgery, Zealand University Hospital, Roskilde, Denmark.

Introduction: Verrucous carcinoma is an uncommon variant of low-grade squamous cell malignancy with a low malignant potential but a high risk of recurrence.

Presentation Of Case: We report a case of a Human Papilloma Virus negative local verrucous carcinoma in the perianal area of a 45-year old otherwise healthy female. The tumor presented clinically as a persistent genital wart not responding to usual dermatologic local therapy. Read More

J Infect Dis 2018 Nov 29. Epub 2018 Nov 29.

National Center for HIV/AIDS, Viral Hepatitis, STD, and TB; Centers for Disease Control and Prevention; Atlanta, GA, USA.

Background: Approximately 90% of genital warts are caused by human papillomavirus (HPV) types 6 and 11. In the US, HPV vaccination has been recommended for females ≤26 years; and since 2011, males ≤21 years and gay, bisexual, and other men who have sex with men (MSM) ≤26 years.

Methods: Data were obtained from 27 clinics participating in the STD Surveillance Network (SSuN). Read More

PLoS One 2018 29;13(11):e0207953. Epub 2018 Nov 29.

Toronto General Hospital, Toronto, Canada.

The human papillomavirus (HPV) is the most common sexually transmitted infection worldwide. Gay, bisexual, and other men who have sex with men (GBM) living with HIV are disproportionately impacted by HPV-associated anal cancer, with rates about 100-fold that of the general population. Fortunately, HPV vaccination has proven efficacy in preventing both anogenital warts (condyloma) in males and anal pre-cancers (anal intraepithelial neoplasia; AIN) in GBM up to the age of 26. Read More

Asian Pac J Cancer Prev 2018 Nov 29;19(11):3039-3044. Epub 2018 Nov 29.

Pathology and Stem Cell Research Center, erman University of Medical Sciences, Kerman, Iran. Email:

Breast cancer is the first of the most important causes of the deaths of women in the world and in Iran. There are various causes and causes of this cancer, one of which has recently been described as a cause of breast cancer, is the human papillomavirus (HPV). The HPV is transmitted through sexual contact and skin lesions. Read More

Front Immunol 2018 12;9:2478. Epub 2018 Nov 12.

Department of Parasitology, Center of Research Excellence on Therapeutic Proteins and Antibody Engineering, Faculty of Medicine SIriraj Hospital, Mahidol University, Bangkok, Thailand.

Human papillomavirus (HPV) is a viral infection with skin-to-skin based transmission mode. HPV annually caused over 500,000 cancer cases including cervical, anogenital and oropharyngeal cancer among others. HPV vaccination has become a public-health concern, worldwide, to prevent the cases of HPV infections including precancerous lesions, cervical cancers, and genital warts especially in adolescent female and male population by launching national programs with international alliances. Read More

Int J STD AIDS 2018 Nov 27:956462418805197. Epub 2018 Nov 27.

1 Dermatology Hospital of Southern Medical University (Guangdong Provincial Dermatology Hospital), Guangzhou, China.

Early syphilis can rarely cause erythema multiforme-type eruptions as well as triggering erythema multiforme (EM). EM-like lesions in secondary syphilis are characterized by clinical features of EM and laboratory tests consistent with secondary syphilis and the skin histology shows predominantly a plasma cell infiltrate with the presence of treponemes. When EM is triggered by early syphilis, the skin histology shows mixed inflammatory cells usually in the absence of treponemes in the skin lesion. Read More

Int J Gynecol Pathol 2018 Nov 21. Epub 2018 Nov 21.

Departments of Pathology (S.I., A.K., W.G.M.) Dermatology (S.H.), Belfast Health and Social Care Trust Belfast Skin Clinic (P.M.) Centre for Medical Education, Queen's University (J.H.), Belfast Department of Pathology, Southmead Hospital, Bristol (K.M.) Department of Pathology, Antrim Area Hospital, Antrim, UK (J.J.).

Epidermolytic acanthoma is a rare benign lesion that most often presents as a solitary or multiple small papular lesions on the trunk, face, limbs or external male genitalia. Only a small number of cases have been reported occurring on the vulva and clinically and histologically they may mimic and be misdiagnosed as viral warts. We report 2 cases of multiple epidermolytic acanthomas localized to the vulva. Read More

Front Zool 2018 23;15:46. Epub 2018 Nov 23.

1Laboratory of Cell Biology, Instituto Butantan, Av. Vital Brasil 1500, São Paulo, 05503-000 Brazil.

Background: Amphibian defence against predators and microorganisms is directly related to cutaneous glands that produce a huge number of different toxins. These glands are distributed throughout the body but can form accumulations in specific regions. When grouped in low numbers, poison glands form structures similar to warts, quite common in the dorsal skin of bufonids (toads). Read More

Indian J Dermatol Venereol Leprol 2018 Nov 23. Epub 2018 Nov 23.

Department of Dermatology, Venereology and Leprosy, GMC, Kota, Rajasthan, India.

Background And Aim: Treatment of palmoplantar warts is a challenge for dermatologists. We aimed to study the efficacy and safety of Falknor's needling method in palmoplantar warts.

Methods: In an open, nonrandomized study, the index wart of eligible patients was punctured several times with a 26-gauge needle to produce a "beefy" red wound. Read More

J Surg Res 2018 Dec 11;232:629-634. Epub 2018 Aug 11.

Division of Colorectal Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin. Electronic address:

Background: Human papillomavirus is a common sexually transmitted infection that may affect the oropharynx, genitalia, or anus. Some strains of this virus may cause bulky growths around the anus known as giant anal condylomas. These can become large, disfiguring, and may cause bleeding, as well as difficulty with defecation and hygiene. Read More

Sex Transm Dis 2018 Nov 19. Epub 2018 Nov 19.

Yale School of Public Health, Department of Epidemiology of Microbial Diseases.

Background: Assessing the impact and effectiveness of HPV vaccines on anogenital warts in the United States can provide early indication of the success of vaccination programs as well as identify potential areas for improvement.

Methods: Articles were identified from the PubMed, Medline, and Embase databases. Exclusion criteria were applied, and remaining studies were then classified as impact or effectiveness studies. Read More

Acta Derm Venereol 2018 Nov 21. Epub 2018 Nov 21.

Department of Dermatology and Allergology, Klinikum rechts der Isar, Technical University of Munich, 80802 Munich, Germany.

Int J Dermatol 2018 Nov 19. Epub 2018 Nov 19.

Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.

J Am Acad Dermatol 2018 Nov 14. Epub 2018 Nov 14.

Department of Dermatology, NDMC Medical College & Hindu Rao Hospital, New Delhi-110007, India.

Urologe A 2018 Dec;57(12):1499-1508

, Terpstig 55, 25980, Sylt OT Morsum, Deutschland.

Vaccination qualifies as the most effective medical procedure worldwide. Using the example of human papillomavirus(HPV)-associated benign and malignant diseases, the incidence, diagnostics, treatment, particularly however, the option of sustainable elimination of all these entities by achieving herd immunity by a gender balanced inoculation quota of 80% at the age of 9-17 years are shown. Read More

Cancer Epidemiol 2018 Nov 12;58:12-16. Epub 2018 Nov 12.

The Kirby Institute, Wallace Wurth Building, UNSW Sydney, Randwick, New South Wales 2031, Australia. Electronic address:

Background: The association between anal high-grade squamous intraepithelial lesion (HSIL) and anal symptoms has not been systematically investigated.

Methods: The Study of Prevention of Anal Cancer is a prospective cohort study of men who have sex with men (MSM) ≥ 35 years old in Sydney, Australia. Self-reported symptoms were collected. Read More

BMC Public Health 2018 Nov 14;18(1):1260. Epub 2018 Nov 14.

Department of Surgery, University of Zimbabwe College of Health Sciences, P.O. Box A178 Avondale, Harare, Zimbabwe.

Background: HIV-infected individuals are at increased risk of anal cancer; in the majority of cases this is linked to human papillomavirus (HPV) infection. Anal cancer screening is not routinely offered in Zimbabwe.

Methods: A cross-sectional study was performed on 152 patients (88 females; 64 males) attending Opportunistic Infection Clinics at 2 tertiary hospitals between November 2014 and June 2015. Read More

Mult Scler 2018 Nov 14:1352458518807088. Epub 2018 Nov 14.

Department of Neurology, Concord Hospital, Concord, NSW, Australia/ Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.

Background:: Fingolimod is used to reduce relapse rates in relapsing-remitting multiple sclerosis (MS). It is a sphingosine 1-phosphate (S1P) analogue having antagonistic effects on S1P receptors. Its immunosuppressive effect is due to reduced circulating lymphocyte numbers, and it may also be associated with impaired intrinsic cancer surveillance. Read More

Mult Scler 2018 Nov 14:1352458518813109. Epub 2018 Nov 14.

Mellen Center for Multiple Sclerosis, Neurological Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.

J Dermatolog Treat 2018 Nov 14:1-18. Epub 2018 Nov 14.

a Department of Dermatology and Venereology , Nanfang hospital, Southern Medical University , Guangzhou , 510515 , China.

Condyloma acuminatum are the most common sexually transmitted diseases worldwide, and they are closely associated with human papillomavirus (HPV) infections. Urethral meatus warts are uncommon. And many treatments are limited by a difficult approach, recurrences, and potential complications. Read More

Acta Derm Venereol 2018 Nov 14. Epub 2018 Nov 14.

Department of Dermatology and Venereology, Skane University Hospital, SE-214 28 Malmö, Sweden. Department of Dermatology and Venereology, Skane University Hospital, SE-214 28 Malmö, Sweden.

Studies on risk factors for penile intraepithelial neoplasia have been small in size, have not distinguished penile intraepithelial neoplasia from invasive cancer, and have relied on self-reported information. This study investigated risk factors for penile intraepithelial neoplasia in a cohort of 580 penile intraepithelial neoplasia cases and 3,436 controls using information from 7 Swedish registers. Cases with penile intraepithelial neoplasia had increased odds ratios (ORs) for inflammatory skin diseases (14. Read More

Vaccine 2018 Nov 24;36(49):7536-7541. Epub 2018 Oct 24.

Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", Via Luciano Armanni, 5, 80138 Naples, Italy. Electronic address:

Background: The objectives of the present cross-sectional study were to investigate the level of knowledge and attitudes regarding Human papillomavirus (HPV) infection and its vaccination and to understand the impact of different determinants among immigrants and refugees in Italy.

Methods: Between September 2016 and March 2018, a total of 519 potential participants were randomly recruited. The information was collected through a questionnaire administered by two researchers. Read More

PLoS One 2018 12;13(11):e0206726. Epub 2018 Nov 12.

Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Brazil.

Background: The World Health Organization has recommended the introduction of HPV vaccines into national immunization programme (NIP), but vaccination coverage remains low worldwide. We assessed the coverage and the parental acceptance of female and male HPV vaccination in Brazil after its introduction into the NIP.

Methods: We conducted a random-digit-dial survey of parents in seven major Brazilian cities from July-2015 to October-2016. Read More

Front Oncol 2018 26;8:422. Epub 2018 Oct 26.

School of Public Health, Texas A&M University, College Station, TX, United States.

People living with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) and, men who have sex with men (MSM) are disproportionately affected by genital warts and cancers caused by human papillomavirus (HPV). We assessed community-based HIV/AIDS service organizations' (ASOs) staff awareness, knowledge, attitudes, and beliefs about HPV and effective cancer prevention tools, namely HPV vaccination, Pap, and HPV tests. The potential engagement of ASO staff in future efforts to reduce the disproportionate burden of genital warts and HPV-related cancers among HIV-positive women and MSM was explored. Read More

Medicine (Baltimore) 2018 Oct;97(43):e12539

Department of Psychiatry, Chiayi Branch, Taichung Veterans General Hospital, Chiayi.

Depressive disorder is a severe mental disorder associated with functional and cognitive impairment. Numerous papers in the literature investigated associations between sexually transmitted infections (STIs) and psychiatric illnesses. However, the results of these studies are controversial. Read More

Sex Transm Infect 2018 Nov 8. Epub 2018 Nov 8.

Melbourne Sexual Health Centre, Alfred Health, Melbourne, Victoria, Australia

Objective: In mid-2017, the Victorian Government funded a free time-limited human papillomavirus (HPV) vaccination catch-up programme for gay and bisexual men who have sex with men (MSM) aged up to 26 years through sexual health clinics or other immunisation centres. We aimed to examine the uptake of the HPV vaccine among young MSM attending the Melbourne Sexual Health Centre (MSHC).

Methods: MSM aged ≤26 attending MSHC between 27 April 2017 and 31 December 2017 were included in the analysis. Read More

Medicine (Baltimore) 2018 Nov;97(45):e13201

Division of Infectious Diseases, Department of Internal Medicine.

Human papillomavirus (HPV) infection is associated with cancer and can be prevented through vaccination. Few studies from Taiwan have reported on HPV infection among human immunodeficiency virus (HIV)-infected subjects. The aim of this study was to examine the prevalence of HPV infection among men who have sex with men (MSM) with and without HIV infection in Taiwan, and explore the behavioral risk factors thereof. Read More

Hand (N Y) 2018 Nov 8:1558944718810895. Epub 2018 Nov 8.

2 Mazandaran University of Medical Sciences, Sari, Iran.

BMC Med Res Methodol 2018 Nov 6;18(1):125. Epub 2018 Nov 6.

UCL Centre for Clinical Research in Infection and Sexual Health, The Mortimer Market Centre, Institute for Global Health, University College London, London, WC1E 6JB, UK.

Background: Anogenital warts are the second most common sexually transmitted infection diagnosed in sexual health services in England. About 90% of genital warts are caused by human papillomavirus (HPV) types 6 or 11, and half of episodes diagnosed are recurrences. The best and most cost-effective treatment for patients with anogenital warts is unknown. Read More

Am J Dermatopathol 2018 Oct 29. Epub 2018 Oct 29.

Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic.

Syringocystadenoma papilliferum (SCAP) is a benign tumor most commonly located on the head and neck area often associated with nevus sebaceus. In its usual location, the human papillomavirus (HPV) DNA and mutations in the RAS/mitogen-activated protein kinase signaling pathway have been detected in SCAP. We studied 16 cases of SCAP in the anogenital areas and buttock where this neoplasm is rare and attempted to find out whether SCAP in these sites have different histopathological and molecular biological features. Read More

Clin Colon Rectal Surg 2018 Nov 2;31(6):321-327. Epub 2018 Nov 2.

Division of Colon and Rectal Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.

Human papillomavirus (HPV) infection is responsible for 4.3% of the global cancer burden. Since 2006, current HPV vaccines have reduced the prevalence of the virus in adolescent girls, reduced the prevalence of genital warts, and been proven to reduce the progression of anal intraepithelial neoplasia in men. Read More

Int J STD AIDS 2018 Nov 5:956462418796088. Epub 2018 Nov 5.

2 Center for Observational and Real-World Evidence, Merck & Co., Inc., Kenilworth, NJ, USA.

Genital warts (GW) are mucosal or skin lesions caused by sexual transmission of human papillomavirus (HPV). This study estimates the frequency of GW cases in physicians' clinics and physicians' usual practices of GW referral and diagnosis in Peru. Participants in this study were a convenience sample of 100 physicians in five specialties: primary care (17), gynecology (37), urology (10), dermatology (31), and infectious diseases (5). Read More

Zhonghua Zhong Liu Za Zhi 2018 Oct;40(10):724-728

Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Prophylactic HPV vaccine was a milestone in the prevention and control of HPV-related diseases, especially cervical cancer. The first HPV vaccine has been marketed in the world for more than 10 years. The follow-up study of HPV vaccine clinical trials further confirms the effectiveness and safety. Read More

J Clin Immunol 2018 Nov 1. Epub 2018 Nov 1.

Department of Pediatrics, Laboratory for Inborn Errors of Immunity, Department of Microbiology and Immunology, University Hospitals Leuven, KU Leuven, Herestraat 49 - bus 7003, 3000, Leuven, Belgium.

Singapore Med J 2018 Oct;59(10):519-523

Department of Dermatology, Singapore General Hospital, Singapore.

Introduction: Lifelong immunosuppression after renal transplant exerts effects on the recipients' skin, including skin infections, skin cancers and drug-induced skin disorders. Our study aimed to determine the epidemiology of skin conditions among renal transplant recipients in the largest tertiary hospital in Singapore.

Methods: We reviewed the medical records of kidney transplant recipients at Singapore General Hospital, Singapore, between 1 January 2003 and 31 December 2013. Read More

J Assoc Nurses AIDS Care 2018 Nov - Dec;29(6):942-948. Epub 2018 May 26.

We used a cross-sectional study in 2011 to estimate prevalence and risk behaviors for self-reported symptomatic sexually transmitted infections (STI) in rural settlers in Midwestern Brazil. There were 353 individuals recruited who had been living in the settlement for more than 6 months. The endpoint variable was having reported vaginal discharge, urethral discharge, genital ulcers, or anogenital warts in the previous 12 months. Read More

J Drugs Dermatol 2018 Oct;17(10):1100-1105

Background: Nitric oxide (NO), a free radical gas, is endogenously produced in human cells. In high concentration, NO neutralizes many disease-causing microbes. The topical investigational drug SB206 releases NO and has the potential to treat skin diseases caused by viruses. Read More

J Cosmet Dermatol 2018 Oct 24. Epub 2018 Oct 24.

Qena Hospital, Qena, Egypt.

Introduction: Common warts are hyperkeratotic, benign cutaneous growths caused by types 1, 2, and 7 Human papilloma viruses. Different modalities are available to treat warts. Cryotherapy is one of the most common and effective treatments for common warts. Read More

J Infect Dis 2018 Oct 22. Epub 2018 Oct 22.

Medical advisor, STI unit, Institut national de santé publique du Québec, Montréal, QC, Canada.

SAGE Open Med Case Rep 2018 10;6:2050313X18802143. Epub 2018 Oct 10.

Division of Dermatology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada.

Condyloma acuminata, also known as anogenital warts, represent a cutaneous infection caused by sexual transmission of the human papilloma virus. We present a case of overwhelming condyloma acuminata that was treated successfully without surgery using only topical imiquimod 3.75% cream. Read More

Pan Afr Med J 2018 29;30:78. Epub 2018 May 29.

Hôpital Civil Tétouan, Tétouan, Maroc.

Epidermodysplasia verruciformis, also known as Lewandowsky-Lutz syndrome or tree man disease is a rare genetic skin disorder. It is characterized by abnormal susceptibility of the skin coating to human papillomaviruses (HPVs). It commonly affects people between the ages of 4 and 8, most often before the age of 20 years but it may exceptionally occur later. Read More

MycoKeys 2018 10(40):111-126. Epub 2018 Oct 10.

Institute of Microbiology, Beijing Forestry University, Beijing 100083, China Beijing Forestry University Beijing China.

Nine species of were subjected to phylogenetic analyses, based on a combined dataset of ITS1-5.8S-ITS2-nrLSU- sequences. The morphology of specimens collected from China and Australia were studied. Read More

J Obstet Gynaecol Can 2018 Oct 16. Epub 2018 Oct 16.

JSS Medical Research, Saint-Laurent, QC.

Publicly funded administration of the quadrivalent HPV (qHPV) vaccine in school-aged girls was implemented for all Canadian provinces and territories between 2007 and 2009. However, the impact of female qHPV vaccination in Canada has yet to be evaluated. This systematic literature review of studies published between September 1, 2006 and September 1, 2016 looked at real-world evidence related to the effects of qHPV vaccination on prevalence of HPV infection and disease in Canada over the past decade. Read More

Sci Rep 2018 Oct 18;8(1):15450. Epub 2018 Oct 18.

Department of Dermatology, 306 Hospital of PLA, Beijing, 100101, China.

In this study, the hands and feet of 15,384 undergraduate and postgraduate students in 3 colleges in Beijing were examined for the presence of cutaneous warts at college-entry, and those diagnosed with warts were followed up 2-3 years later. We identified totally 215 (1.4%; 95% CI, 1. Read More

Clinics (Sao Paulo) 2018 10 11;73(suppl 1):e486s. Epub 2018 Oct 11.

Centro de Pesquisa Translacional em Oncologia, Instituto do Cancer do Estado de Sao Paulo (ICESP), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Human papillomavirus infection is associated with the development of malignant and benign neoplasms. Approximately 40 viral types can infect the anogenital mucosa and are categorized into high- and low-risk oncogenic human papillomavirus, depending on their association with the development of cervical carcinoma. High-risk human papillomavirus 16 and 18 are detected in 55% and 15% of all invasive cervical squamous cell carcinomas worldwide, respectively. Read More

Euro Surveill 2018 Oct;23(41)

Robinson Research Institute and Adelaide Medical School, University of Adelaide, North Adelaide, Australia.

Background: A National human papilloma virus (HPV) Vaccination Programme for the prevention of HPV infection and associated disease using the quadrivalent HPV vaccine (4vHPV) has been funded and implemented in Australia since 2007, initially for girls only and extended to boys in 2013, with uptake rates among the highest observed worldwide.

Aim: We report on the impact of this national programme on HPV prevalence and associated disease burden and estimate the potential impact of adopting a nonavalent HPV (9vHPV) vaccine.

Methods: We performed a non-systematic literature review of studies measuring the burden of HPV-associated disease and infection in Australia before and after introduction of HPV vaccination. Read More

Rev Med Brux 2018;39(4):352-358

Service de Maladies infectieuses et tropicales, CHU Ambroise Paré, Mons.

High-risk oncogenic HPVs (HR-HPV) are associated in men with pre-cancerous anal dysplasia, oropharyngeal, anal and penile cancer. Anogenital warts are induced by low-risk HPVs. These manifestations are increasing among men, and especially in some high-risk groups as men who have sex with men (MSM). Read More

Lasers Surg Med 2018 Oct 15. Epub 2018 Oct 15.

Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts.

Objective: Lidocaine acts as a local anesthetic by blocking transmembrane sodium channel permeability, but also induces the synthesis of heat shock proteins and sensitizes cells to hyperthermia. A previous study reported two cases of deep focal skin ulceration at points corresponding to depot local lidocaine injection sites after treatment with non-ablative fractional resurfacing and it was hypothesized that lidocaine had focally sensitized keratinocytes to the thermal damage of laser treatment. The objective of this study was to investigate whether lidocaine potentiates hyperthermia damage to both normal and cancerous skin cells using an in vitro model. Read More

Zootaxa 2018 May 11;4418(6):562-576. Epub 2018 May 11.

State Key Laboratory of Biocontrol / The Museum of Biology, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, P.R. China.

A new species, Amolops yunkaiensis sp. nov. is described based on a series of specimens from Ehuangzhang Nature Reserve and Yunkaishan Nature Reserve, southwestern Guangdong Province, China. Read More