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    Cost-effectiveness of HPV vaccination in the context of high cervical cancer incidence and low screening coverage.
    Vaccine 2017 Sep 9. Epub 2017 Sep 9.
    Institute of Family Medicine and Public Health, University of Tartu, Tartu, Estonia.
    Background: Estonia has high cervical cancer incidence and low screening coverage. We modelled the impact of population-based bivalent, quadrivalent or nonavalent HPV vaccination alongside cervical cancer screening.

    Methods: A Markov cohort model of the natural history of HPV infection was used to assess the cost-effectiveness of vaccinating a cohort of 12-year-old girls with bivalent, quadrivalent or nonavalent vaccine in two doses in a national, school-based vaccination programme. Read More

    Lifestyle factors and oncogenic papillomavirus infection in a high-risk male population.
    PLoS One 2017 12;12(9):e0184492. Epub 2017 Sep 12.
    Department of Urology, University Hospital of Vigo, Vigo, Spain.
    Background: High risk human papillomavirus (HR-HPV) infection in males is a health issue with implications for HPV-related lesions in their partners. The identification of risk factors for male infection may improve our understanding of HR-HPV transmission and prevention. The aim of this study was to evaluate the relationships between lifestyle, genital warts and HR-HPV infection. Read More

    Tumour virus vaccines: hepatitis B virus and human papillomavirus.
    Philos Trans R Soc Lond B Biol Sci 2017 Oct;372(1732)
    Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK
    Two of the most important human oncogenic viruses are hepatitis B virus (HBV) and human papillomavirus (HPV). HBV infection has been preventable by vaccination since 1982; vaccination of neonates and infants is highly effective, resulting already in decreased rates of new infections, chronic liver disease and hepato-cellular carcinoma. Nonetheless, HBV remains a global public health problem with high rates of vertical transmission from mother to child in some regions. Read More

    Attitudes towards Human Papilloma Virus Vaccination in the Latin American Andean Region.
    Healthcare (Basel) 2017 Sep 8;5(3). Epub 2017 Sep 8.
    Obstetrics and Gynecology Locum Tenens, Salinas, CA 93902, USA.
    This commentary explores the distribution of human papilloma virus (HPV) and HPV-related diseases, and factors affecting attitudes towards HPV, HPV-related diseases, and HPV vaccination in the Latin American Andean region. Lack of knowledge of HPV, known negative attitudes or incorrect assumptions about HPV, HPV-related diseases, and HPV vaccination provide a basis upon which to develop targeted HPV awareness and preventive health media campaigns. For maximal effect, media campaigns should use the internet, radio, and television to address health care providers, parents, and students. Read More

    Cost-effectiveness of human papillomavirus vaccination in Germany.
    Cost Eff Resour Alloc 2017 4;15:18. Epub 2017 Sep 4.
    Department of Health Economics and Health Care Management, School of Public Health, Bielefeld University, Universitätsstraße 25, 33615 Bielefeld, Germany.
    Background: The aim of this study was to assess the cost-effectiveness of human papillomavirus (HPV) vaccination in addition to the current cervical cancer screening programme in Germany using a dynamic transmission model.

    Methods: Based on a mathematical model simulating the transmission dynamics and the natural history of HPV infection and associated diseases (cervical intraepithelial neoplasia, cervical cancer, and genital warts), we estimated the epidemiological and economic consequences of HPV vaccination with both the quadrivalent and bivalent vaccines. In our base case analysis, we assessed the cost-effectiveness of vaccinating 12-year-old girls with a 3-dose schedule. Read More

    Understanding the Effects of Forced Sex on Sexually Transmitted Disease Acquisition and Sexually Transmitted Disease Care: Findings From the National Survey of Family Growth (2011-2013).
    Sex Transm Dis 2017 Oct;44(10):613-618
    From the *Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA; and †Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN.
    Background: Although there is evidence for heightened sexually transmitted disease (STD) acquisition among women who experienced sexual violence, little is known about their patterns of STD testing, STD diagnosis, and STD treatment.

    Methods: Data was drawn from cycle eight of the National Survey of Family Growth (2011-2013). Logistic regression analyses used SUDAAN to examine the link between forced sex and risky sexual behavior as well as forced sex and STD testing, diagnoses, treatment, and connection to care. Read More

    Recurrence of Human Papillomavirus External Genital Wart Infection Among High-Risk Adults in Montréal, Canada.
    Sex Transm Dis 2017 Jun 20. Epub 2017 Jun 20.
    From the *Clinique Médicale l'Actuel; †Sexually Transmitted Infections Unit, Institut National de Santé Publique du Québec, Montréal; ‡JSS Medical Research, Saint-Laurent; and §Merck Canada, Montréal, Québec, Canada.
    Objectives: The incidence of recurrent genital warts is not well characterized; this is especially true in a post-human papillomavirus (HPV) vaccination era. The objectives of this study were to assess the incidence of subsequent HPV-related external genital warts (EGW) episodes in high-risk male and female adults, as well as ascertain patient profile and disease characteristics, in a real-world Canadian sexual health clinical setting.

    Methods: Retrospective chart review study conducted at Clinique médicale l'Actuel, a sexual health clinic in Montréal, Québec, Canada. Read More

    Topical Imiquimod is an Effective and Safe Drug for Molluscum Contagiosum in Children.
    Acta Dermatovenerol Croat 2017 Jul;25(2):164-166
    Efstathia Pasmatzi, MD, Department of Dermatology School of Medicine University of Patras, 26504 Rio-Patras, Greece;
    Dear Editor, Molluscum contagiosum (MC) is a very common skin infection caused by a molluscipox virus gene of the poxvirus family. It usually occurs in young children, sexually active adults, and immunocompromised individuals. The typical clinical picture of this infection is characterized by asymptomatic flesh-colored, single or multiple papules, measuring 2-6 mm in diameter with a central umbilication that occur on the skin and the mucous membranes. Read More

    Efficacy and Tolerability of Polyphenon E in "Difficult-to-Treat" Multiple Genital Warts in an HIV-Positive Male Subject.
    Case Rep Dermatol 2017 May-Aug;9(2):55-59. Epub 2017 Jun 27.
    Medical Department, Difa Cooper, Caronno, Italy.
    A 55-year-old man, nonsmoker, with a HIV-positive history came to our attention in February 2017. He was on treatment with Stribild(TM), 1 capsule daily (150 mg elvitegravir, 150 mg cobicistat, 200 mg emtricitabine, and 245 mg tenofovir disoproxil). The CD4+/CD8+ cellular count was 326/µL (normal values: 404-1,612); the CD3+/CD8+ cellular count was 819/µL (normal values: 220-1,219). Read More

    Detection of human papillomavirus in urine among heterosexual men in relation to location of genital warts and circumcision status.
    Sex Transm Infect 2017 Sep 2. Epub 2017 Sep 2.
    Melbourne Sexual Health Centre, Alfred Health, Melbourne, Victoria, Australia.
    Objective: Human papillomavirus (HPV) surveillance is important to monitor the effectiveness of national HPV vaccination programmes. Positivity of HPV in urine in men varies with different sampling methods. We aimed to determine the positivity for detection of HPV-6/11 in urine samples among men in relation to the position of genital warts and circumcision status. Read More

    Prevalence of anogenital HPV infection, related disease and risk factors among HIV-infected men in inner-city Johannesburg, South Africa: baseline findings from a cohort study.
    BMC Public Health 2017 Jul 4;17(Suppl 3):425. Epub 2017 Jul 4.
    Wits Reproductive Health and HIV Institute (WRHI), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
    Background: Persistent high-risk human papillomavirus (HR-HPV) infection is associated with the development of anogenital cancers, particularly in men living with HIV (MLWH). We describe the prevalence of anogenital HPV infection, abnormal anal cytology and anogenital warts (AGWs) in MLWH in Johannesburg, and explore whether HPV infection and receipt of antiretroviral treatment is associated with detection of abnormal anal cytology and AGWs.

    Methods: We enrolled a cohort of 304 sexually-active MLWH ≥18 years, who completed a questionnaire and physical examination. Read More

    "My mom said it wasn't important": A case for catch-up human papillomavirus vaccination among young adult women in the United States.
    Prev Med 2017 Aug 18;105:1-4. Epub 2017 Aug 18.
    Department of Community and Family Health, College of Public Health, University of South Florida, 13201 Bruce B. Downs Blvd. MDC 56, Tampa, FL 33612, USA. Electronic address:
    The human papillomavirus (HPV) vaccine prevents HPV-related diseases, including anogenital cancers and genital warts. In the United States, while it is recommended to adolescents ages 11 to 12, catch-up vaccination is available for those previously unvaccinated until age 26. Parental decisions or lack of provider recommendation during adolescence are barriers to on-time vaccination. Read More

    Knowledge, Beliefs and Attitudes of Somali Men in Olmsted County, Minnesota, U.S., on the Human Papillomavirus Vaccine and Cervical Cancer Screening: January 17, 2015.
    J Immigr Minor Health 2017 Aug 16. Epub 2017 Aug 16.
    School of Public Health, University of Minnesota, Minneapolis, MN, USA.
    This study explores the general knowledge of Human Papillomavirus vaccine (HPV) and cervical cancer screening (CCS) among Somali men in the U.S., who are major decision-makers in Somali households. Read More

    The cytotoxic mechanism of epigallocatechin gallate on proliferative HaCaT keratinocytes.
    J Biomed Sci 2017 Aug 15;24(1):55. Epub 2017 Aug 15.
    Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, 114, Taiwan, Republic of China.
    Background: Epigallocatechin gallate (EGCG) is the major ingredient of sinecatechins ointment, approved for the treatment of external genital and perianal warts. However, the molecular mechanism for EGCG's effect on warts resulting from the human papillomavirus (HPV) infection of keratinocytes is not well understood. HPV may survive in proliferative keratinocytes and may be involved in cell cycle regulation and progression. Read More

    HPV-11 variability, persistence and progression to genital warts in men: the HIM study.
    J Gen Virol 2017 Sep 15;98(9):2339-2342. Epub 2017 Aug 15.
    1​Molecular Biology Laboratory, Center for Translational Research in Oncology, Instituto do Cancer do Estado de Sao Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
    HPV-11 and HPV-6 are the etiological agents of about 90 % of genital warts (GWs). The intra-typic variability of HPV-11 and its association with infection persistence and GW development remains undetermined. Here, HPV infection in men (HIM) participants who had an HPV-11 genital swab and/or GW, preceded or not by a normal skin genital swab were analysed. Read More

    Molecular Screening and Single Nucleotide Polymorphism Typing of Molluscum Contagiosum Virus (MCV) from Genital Specimens, between 2012 and 2015
    Iran Biomed J 2017 08 15. Epub 2017 Aug 15.
    Research and Development (R&D) Department, Keyvan Virology Specialty Laboratory (KVSL), Tehran, Iran.
    Background: The present study is the first comprehensive report of the Molluscum contagiosum virus (MCV) in Iran based on the molecular technique for differentiation and typing of the MCV1 and MCV2.

    Methods: Patients were diagnosed as having tumor-like genital warts less than 5 mm in diameter, and HIV seronegative samples were chosen for this cross-sectional study. TaqMan real-time PCR was used to identify MCV following clinical examination. Read More

    Risk of cancer in patients with genital warts: A nationwide, population-based cohort study in Taiwan.
    PLoS One 2017 14;12(8):e0183183. Epub 2017 Aug 14.
    Department of Pediatrics, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan.
    Background: Condyloma acuminata currently affects around 1% of sexually active adults, and its incidence is increasing. The coexistence of genital warts (GW) and certain cancers and an association between human papillomavirus (HPV) and various malignancies have been reported. Therefore, we conducted this large national study to analyze the risk of malignancies among men and women with GW in Taiwan. Read More

    Progress in prophylactic human papillomavirus (HPV) vaccination in 2016: A literature review.
    Vaccine 2017 Aug 8. Epub 2017 Aug 8.
    Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Zaloška 4, 1000 Ljubljana, Slovenia. Electronic address:
    Prophylactic human papillomavirus (HPV) vaccine represents a revolutionary step forward in preventing HPV-related cancers, especially cervical carcinoma. Alongside appropriate screening, it has the potential to dramatically reduce cervical cancer incidence and even eradicate it. Following extensive evaluations in clinical trials, the first decade of routine HPV vaccine use provides overwhelming evidence of the vaccines' safety and their real-life effectiveness. Read More

    The human papillomavirus replication cycle, and its links to cancer progression: a comprehensive review.
    Clin Sci (Lond) 2017 Sep 10;131(17):2201-2221. Epub 2017 Aug 10.
    MRC-University of Glasgow Centre for Virus Research; Institute of Infection, Immunity and Inflammation; College of Medical, Veterinary and Life Sciences, University of Glasgow, Garscube Estate, Glasgow G61 1QH, Scotland, U.K.
    HPVs (human papillomaviruses) infect epithelial cells and their replication cycle is intimately linked to epithelial differentiation. There are over 200 different HPV genotypes identified to date and each displays a strict tissue specificity for infection. HPV infection can result in a range of benign lesions, for example verrucas on the feet, common warts on the hands, or genital warts. Read More

    Antibody persistence and evidence of immune memory at 5years following administration of the 9-valent HPV vaccine.
    Vaccine 2017 Sep 5;35(37):5050-5057. Epub 2017 Aug 5.
    Merck & Co., Inc., Kenilworth, NJ, USA. Electronic address:
    Background: The 9-valent HPV (9vHPV) vaccine was developed to prevent infection and disease related to 9 HPV types (HPV6/11/16/18/31/33/45/52/58) which cause approximately 90% of cervical cancers, HPV-related vulvar, vaginal and anal cancers, and genital warts worldwide. In a pivotal efficacy study, the 9vHPV vaccine prevented infection and disease due to the 9 vaccine types. Duration of protection remains to be determined. Read More

    Functional characterization of CD4 and CD8 T cell responses among human papillomavirus infected patients with ano-genital warts.
    Virusdisease 2017 Jun 13;28(2):133-140. Epub 2017 Jun 13.
    Department of Transplant Immunology & Immunogenetics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029 India.
    Ano-genital warts are considered one of the commonest and highly infectious sexually transmitted infections. These warts are primarily caused by the human papillomavirus (HPV) of the family Papillomaviridae, genus alpha-papillomavirus, species 10 and types 6 and 11. However the high recurrence rate of warts is a matter of serious concern to the patients and a challenge for the treating physician. Read More

    Missed opportunities for catch-up human papillomavirus vaccination among university undergraduates: Identifying health decision-making behaviors and uptake barriers.
    Vaccine 2017 Jul 26. Epub 2017 Jul 26.
    Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Rd NE, Atlanta, GA 30322, USA; Hubert Department of Global Health, Rollins School of Public Health, Emory University, 1518 Clifton Rd NE, Atlanta, GA 30322, USA; Emory Vaccine Center, 954 Gatewood Rd, Atlanta, GA 30329, USA; Department of Pediatrics, School of Medicine, Emory University, 201 Dowman Dr, Atlanta, GA 30322, USA. Electronic address:
    Background: Suboptimal adolescent human papillomavirus (HPV) vaccine rates in the US highlight the need for catch-up vaccination. When teenagers enter college, there may be a shift in healthcare decision-making from parents and guardians to the students themselves. Little is known about factors influencing college students' healthcare decision-making processes. Read More

    The Cost-Effectiveness of Quadrivalent Human Papillomavirus Vaccination in Indonesia
    Asian Pac J Cancer Prev 2017 07 27;18(7):2011-2017. Epub 2017 Jul 27.
    Indonesian Technical Advisory Group on Immunization (ITAGI), Indonesia. Email:
    Objective: National cervical cancer prevention program has been initiated in Indonesia since April 2015 and the ministry of health has started efforts to integrate the HPV Vaccine in the national immunization program since Q4 2015. Thus, it becomes important to analyze the cost-effectiveness of HPV vaccine. The objective of this model is to examine the potential long-term epidemiologic and economic impact of quadrivalent HPV(qHPV;6/11/16/18) vaccination program in Indonesia. Read More

    Sexual inactivity and occurrence of STIs in relation to weight status in women: Two large population-based studies.
    Women Health 2017 Jul 25:1-16. Epub 2017 Jul 25.
    a Unit of Virus, Lifestyle and Genes , Danish Cancer Society Research Centre , Copenhagen , Denmark.
    The aim of this study was to examine sexual inactivity and occurrence of selected sexually transmitted infections in relation to body mass index. We used data from two large Danish population-based cross-sectional studies conducted in 1991-1995 (HPV study: 6869 women, aged 22-32 years) and in 2004-2005 (Liva study: 19,484 women, aged 18-45 years). Data were collected using a structured interview and measured weight, height, high-risk human papillomavirus DNA, Chlamydia DNA for the HPV study and a structured questionnaire for the Liva study. Read More

    Atypical morphology of anogenital warts is not a marker of atypical histology or of infection to the high-risk human papillomavirus genotypes.
    Int J Dermatol 2017 Oct 25;56(10):1017-1021. Epub 2017 Jul 25.
    Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
    Background: The clinical morphology of anogenital warts may vary from flat, filiform, papular, or verrucous to giant condyloma acuminatum. Clinically atypical-looking genital warts may alarm the clinician because of their suspected malignant potential, which may cause anxiety, often leading to aggressive interventions.

    Objective: To study if clinically atypical-looking anogenital warts are more likely to be premalignant or malignant as compared to typical warts. Read More

    The first case of lymphogranuloma venereum in a woman in East-Central Europe and its multiple co-infections.
    Folia Microbiol (Praha) 2017 Jul 24. Epub 2017 Jul 24.
    Department of Dermatovenereology, Second Faculty of Medicine, Charles University and Hospital Bulovka, Budinova 2, 180 81, Prague 8, Czech Republic.
    We are reporting the first case of lymphogranuloma venereum in women in East-Central Europe. A 22-year-old heterosexual woman attended our department of venereology. She complained about a burning sensation in the urethra and vaginal discharge. Read More

    Human Papillomavirus Infection and Vaccination in Males.
    Eur Urol Focus 2016 Oct 12;2(4):355-362. Epub 2016 Sep 12.
    Università Vita-Salute San Raffaele, Milan, Italy; Division of Experimental Oncology/Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy.
    Context: Human papillomavirus (HPV) is the commonest sexually transmitted pathogen in humans and is linked to the aetiopathogenesis for both benign and malignant disease in men.

    Objective: To evaluate and summarise the evidence for HPV infection and vaccination in men.

    Evidence Acquisition: A search of Medline, PubMed, and Scopus was performed to identify articles published in English within the last 10 yr addressing HPV epidemiology, the natural history of HPV infection and its long-term consequences, and vaccination in men. Read More

    The feminization of HPV: How science, politics, economics and gender norms shaped U.S. HPV vaccine implementation.
    Papillomavirus Res 2017 Jun 23;3:142-148. Epub 2017 Apr 23.
    Department of Anthropology, Rollins College, Winter Park, FL, USA. Electronic address:
    Human papillomavirus (HPV) can cause a number of anogenital cancers (i.e., cervical, penile, anal, vaginal, vulvar) and genital warts. Read More

    Cost-effectiveness analysis of the nine-valent HPV vaccine in Italy.
    Cost Eff Resour Alloc 2017 11;15:11. Epub 2017 Jul 11.
    Sanofi Pasteur MSD, Lyon, France.
    Background: In Italy HPV vaccination with the quadrivalent vaccine (Gardasil(®)) is offered actively and free of charge to girls aged 12 since 2007. A nine-valent vaccine (Gardasil 9(®)) received the European market authorization in 2015 to protect, with only 2 doses, against around 90% of all HPV positive cancers, over 80% of high-grade precancerous lesions and 90% of genital warts caused by HPV types 6/11.

    Methods: A dynamic transmission model simulating the natural history of HPV-infections was calibrated to the Italian setting and used to estimate costs and QALYs associated with vaccination strategies. Read More

    Two Landmark Studies Published in 1976/1977 Paved the Way for the Recognition of Human Papillomavirus as the Major Cause of the Global Cancer Burden.
    Acta Cytol 2017 11;61(4-5):316-337. Epub 2017 Jul 11.
    Department of Clinical Research, Biohit Oyj, Helsinki, Finland; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil.
    Two groundbreaking reports were published in Acta Cytologica at the transition of 1976 to 1977. One appeared in the last issue of 1976 [Meisels and Fortin: Acta Cytol 1976;20:505-509] and the other in the first issue of 1977 [Purola and Savia: Acta Cytol 1977;21:26-31]. Today, 40 years later, it is not an overstatement to conclude that these are the two most influential studies ever published in this journal. Read More

    A cross-sectional study estimating the burden of illness related to genital warts in South Korea.
    BMJ Open 2017 Jul 2;7(6):e014217. Epub 2017 Jul 2.
    Obstetrics and Gynaecology, Ewha Woman's University, School of Medicine, Seoul, South Korea.
    Objectives: Estimate the prevalence of genital warts (GW) and GW-related healthcare resource use and costs among male and female patients seeking treatment in South Korea.

    Design: To estimate GW prevalence, physicians in five major South Korean regions recorded daily logs of patients (n=71 655) seeking care between July 26 and September 27, 2011. Overall prevalence estimates (and 95% CIs) were weighted by the estimated number of physicians in each specialty and the estimated proportion of total patients visiting each specialist type. Read More

    Human papillomavirus vaccination: the population impact.
    F1000Res 2017 12;6:866. Epub 2017 Jun 12.
    Department of Microbiology and Infectious Diseases, Royal Women's Hospital, Parkville, Victoria, Australia.
    We currently have the knowledge and experience to prevent much of human papillomavirus (HPV)-related disease burden globally. In many countries where prophylactic HPV vaccination programs have been adopted as highly effective public health programs with good vaccine coverage, we are already seeing, in real-world settings, reduction of vaccine-related HPV-type infections, genital warts and cervical pre-cancers with potential reductions in vulvar, vaginal and anal pre-cancers. Moreover, we are seeing a change in cervical screening paradigms, as HPV-based screening programs now have strong evidence to support their use as more sensitive ways to detect underlying cervical abnormalities, as compared with conventional cervical cytology. Read More

    Cryotherapy to treat anogenital warts in nonimmunocompromised adults: Systematic review and meta-analysis.
    J Am Acad Dermatol 2017 Sep 23;77(3):518-526. Epub 2017 Jun 23.
    Antilles-Guyane University, Fort-de-France, Martinique; Délégation à la Recherche Clinique et à l'Innovation, Centre Hospitalier Universitaire de Martinique, Fort-de-France, Martinique; Department of Dermatology, Centre Hospitalier Universitaire de Martinique, Fort-de-France, Martinique.
    Background: Cryotherapy is one of the most commonly used therapeutic modalities to treat anogenital warts (AGWs), but this treatment was not clearly established in the recent international recommendations.

    Objective: To compare the efficacy and safety of cryotherapy versus other AGW treatments.

    Methods: Through a systematic search of 12 electronic databases, we identified 11 randomized controlled trials, screened from database inception through October 2016, that met the inclusion criteria (including immunocompetent adults with AGWs receiving cryotherapy in 1 of the comparison groups). Read More

    Radiology Case of the Month: Idiopathic CD4 Lymphocytopenia.
    J La State Med Soc 2017 May-Jun;169(3):85-87. Epub 2017 Jun 23.
    Department of Radiology at Tulane University, Health Sciences Center - New Orleans, LA.
    A 39 year-old male with a history of diabetes, retinitis pigmentosa, and genital warts presented with intractable occipital headaches accompanied with nausea and vomiting. The patient had markedly depressed CD4 counts. Furthermore the patient tested negative for HIV and HTLV 1/2 and had normal immunoglobulin levels. Read More

    Louisiana Physicians Are Increasing HPV Vaccination Rates.
    J La State Med Soc 2017 May-Jun;169(3):63-67. Epub 2017 Jun 23.
    Louisiana State University Health Sciences Center, School of Medicine - New Orleans, LA.
    Human papilloma virus (HPV) is a common virus that can cause genital warts and certain cancers. The HPV vaccine is effective in preventing many HPV-associated diseases, however, vaccination rates suggest many remain unprotected. This study examined successful strategies used by physicians to improve HPV vaccination rates. Read More

    Human Papillomavirus Vaccine Dose Effectiveness Against Incident Genital Warts in a Cohort of Insured US Females.
    Am J Epidemiol 2017 Jun 21. Epub 2017 Jun 21.
    We examined effectiveness of HPV vaccination by dose number and interval against incident genital warts in a cohort of 64,517 females in the United States during 8/2006-9/2012. Eligible females were classified into 0, 1-dose, 2-dose < 6 months apart, 2-dose ≥6 months apart, and 3-dose groups and followed until genital wart diagnosis, loss to follow-up, or end of study. Propensity score weights were used to balance baseline differences across groups. Read More

    Oral and oropharyngeal papillomas are not associated with high-risk human papillomavirus infection.
    Eur Arch Otorhinolaryngol 2017 Jun 21. Epub 2017 Jun 21.
    Department of Laryngology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
    The role of different types of human papillomavirus (HPV) in the development of oral and oropharyngeal papillomas remains unclear. High-risk HPV (HR-HPV) was shown to be involved in the pathogenesis of significant proportion of squamous cell carcinomas of the oropharynx. In this study, we hypothesized that in some oropharyngeal papillomas, low-risk HPV (LR-HPV) and HR-HPV infection could co-exist, similar to what is observed in genital warts, and thus contribute to the elevated risk of malignancy. Read More

    Association between sexual mixing and genital warts in heterosexual men in Australia: the herd protection from the female human papillomavirus vaccination program.
    Sex Health 2016 Oct;13(5):489-490
    Melbourne Sexual Health Centre, Alfred Health, 580 Swanston Street, Carlton, Vic. 3053, Australia.
    Australian-born women aged ≤32 years were eligible for the free female human papillomavirus (HPV) vaccination program introduced in 2007. A total of 1165 heterosexual couples attending the Melbourne Sexual Health Centre between 2011 and 2014 were included in this analysis. Findings showed the odds of having penile warts was 0. Read More

    Sexual Behaviors and Sexually Transmitted Infections Among Male Veterans and Nonveterans.
    Am J Mens Health 2017 Jul 22;11(4):791-800. Epub 2017 Mar 22.
    3 Center for Women's Health Research and Innovation, Pittsburgh, PA, USA.
    Little is known about the sexual health of male veterans. This study used nationally representative data from the 2011 to 2013 National Survey of Family Growth to compare sexual behaviors and history of sexually transmitted infections (STIs) between male veterans and nonveterans. The sample included 3,860 men aged 18 to 44 years who reported ever having sex with a man or woman. Read More

    Cervical Cancers Manifest a High Rate of Infection by a High-Risk Human Papilloma Virus Subtype but a Very Low Rate of Infection by a Low-Risk Subtype in the Guiyang District of China.
    J Cancer 2017 11;8(7):1263-1270. Epub 2017 May 11.
    Central Laboratory, Guizhou Medical University Hospital, Guiyang, Guizhou 550004, P. R. China.
    The prevalence of infection by different genotypes of human papillomavirus (HPV) varies among different geographic areas. We studied the prevalence of infection by 21 HPV genotypes in cervical tissue specimens from 4213 women in the Guiyang district, that is located in the southwest of China and is dominated by minor ethnicities of Chinese, and 2074 cases in our cohort had pathological diagnosis available. The overall infection rate was 36. Read More

    Relationship between maternal experiences and adolescent HPV vaccination.
    Hum Vaccin Immunother 2017 Sep 12;13(9):2150-2154. Epub 2017 Jun 12.
    a Center for Interdisciplinary Research in Women's Health, University of Texas Medical Branch , Galveston , TX , USA.
    The human papillomavirus (HPV) vaccine has been available for over a decade but its uptake rate is still low. To explore the relationship between the HPV vaccination status of a child and their mother's beliefs, behaviors and knowledge, we surveyed 1497 women with at least one child aged 9-17 y between September 2011 and November 2015. Physician recommendation was the most important factor associated with reported child vaccination status. Read More

    Impact of quadrivalent human papillomavirus vaccine on genital warts in an opportunistic vaccination structure.
    Gynecol Oncol 2017 Aug 8;146(2):299-304. Epub 2017 Jun 8.
    Cervical clinic, Maccabi Health Services, Tel Aviv, Israel.
    Objective: Genital warts are the most common sexually transmitted disease and have a detrimental impact on quality of life. Genital warts could be prevented by prophylactic HPV vaccination. The objective was to study real-life benefit of opportunistic HPV vaccination on age and gender specific incidence of genital warts. Read More

    Calcein represses human papillomavirus 16 E1-E2 mediated DNA replication via blocking their binding to the viral origin of replication.
    Virology 2017 Aug 29;508:180-187. Epub 2017 May 29.
    VCU Philips Institute for Oral Health Research, Virginia Commonwealth University School of Dentistry, Department of Oral and Craniofacial Molecular Biology, Richmond, VA 23298, USA; VCU Massey Cancer Center, Richmond, VA 23298, USA. Electronic address:
    Human papillomaviruses are causative agents in several human diseases ranging from genital warts to ano-genital and oropharyngeal cancers. Currently only symptoms of HPV induced disease are treated; there are no antivirals available that directly target the viral life cycle. Previously, we determined that the cellular protein TopBP1 interacts with the HPV16 replication/transcription factor E2. Read More

    Sinecatechins and imiquimod as proactive sequential therapy of external genital and perianal warts in adults.
    Int J STD AIDS 2017 Jan 1:956462417711622. Epub 2017 Jan 1.
    8 Dermatology Department, University of Brescia, Brescia, Italy.
    This review about the proactive sequential therapy (PST) of external genital and perianal warts (EGW) is based on the most current available clinical literature and on the broad clinical experience of a group of international experts, physicians who are well versed in the treatment of human papillomavirus-associated diseases. It provides a practical guide for the treatment of EGW, including epidemiology, etiology, clinical appearance, and diagnostic procedures for these viral infections. Furthermore, the treatment goals and current treatment options, elucidating provider- and patient-applied therapies, and the parameters driving treatment decisions are summarized. Read More

    Prevalence and risk factors associated with sexually transmitted infections (STIs) among women of reproductive age in Swaziland.
    Infect Agent Cancer 2017 25;12:29. Epub 2017 May 25.
    Discipline of Public Health, School of Nursing and Public Health, University of KwaZulu-Natal, 2nd Floor George Campbell Building, Mazisi Kunene Road, 4041 Durban, South Africa.
    Background: Sexually transmitted infections (STIs) remain an important public health problem with approximately half a billion new cases annually among persons aged 15-49 years. Epidemiological data on STIs among women of reproductive age in Swaziland are limited. The availability of epidemiological data on STIs and associated risk factors in this population is essential for the development of successful prevention, diagnosis and management strategies in the country. Read More

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