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Sci Rep 2021 May 10;11(1):9855. Epub 2021 May 10.

Marsa Sexual Health Center, Beirut, Lebanon.

Access to sexual and reproductive health in conservative communities and in the MENA region are particularly limited and, as such, increase women's vulnerability to unwanted pregnancies, unsafe abortions, and sexually transmitted infections (STIs). The aim was to assess the prevalence of STIs, sexual practices, recreational drug-use and their possible associations among cisgender unmarried women residing in Lebanon. Data on demographics, sexual practices and substance-use were collected from 2083 unmarried cisgender women who voluntarily attended a sexual health clinic in Lebanon between 2015 and 2019. Read More

J Cancer Educ 2021 May 3. Epub 2021 May 3.

Department of Epidemiology, School of Public Health, University of Alabama At Birmingham, 1665 University Blvd, Birmingham, AL, 35294-0022, USA.

Human papillomavirus (HPV) is a common sexually transmitted disease worldwide. While burden of HPV-associated cancers and mortality is higher in low-income countries, there is limited data about knowledge of it among health care students and professionals. We assessed awareness and knowledge of HPV, its related diseases, and HPV vaccine among 333 participants, composed of 146 medical students (MSs) and professionals (MPs) and 187 nursing students (NSs) and professionals (NPs) using a 40-question survey between July 2018 and February 2019. Read More

Front Pharmacol 2021 12;12:628434. Epub 2021 Apr 12.

Merck Sharp & Dohme, Lyon, France.

Routine human papillomavirus (HPV) immunization in Belgium is currently regionally managed, with school-aged girls receiving the 9-valent HPV (9vHPV) vaccine in Flanders and Wallonia-Brussels with a national catch-up program for females only. This study will assess whether expanding these programs to gender-neutral vaccination (GNV) with the 9vHPV vaccine is a cost-effective strategy in Belgium. A validated HPV-type transmission dynamic model estimated the potential health and economic impact of regional vaccination programs, comparing GNV versus female-only vaccination (FOV) with the 9vHPV vaccine in individuals aged 11-12 years in Flanders, GNV with the 9vHPV vaccine versus FOV with the 2-valent HPV (2vHPV) vaccine in individuals aged 12-13 years in Wallonia-Brussels, and national catch-up GNV versus FOV with the 9vHPV vaccine for those aged 12-18 years. Read More

Indian J Dermatol 2021 Jan-Feb;66(1):44-48

Department of Dermatology, Venereology and Leprosy, GMC, Kota, Rajasthan, India.

Background: Extra-genital warts (EGWs) affect 7-10% of population. Even though a plethora of studies have been conducted to assess the impact of genital warts (GWs) showing a significant impact on the quality of life but surprisingly, barely any data has been collected on the impact of EGWs on quality of life.

Aims And Objective: This cross-sectional study aimed at comparing the magnitude of EGWs on health-related quality of life and various variables with that of GWs. Read More

Int J Womens Dermatol 2020 Dec 12;6(5):429-430. Epub 2020 Jun 12.

Department of Dermatology, Northwestern University, Chicago, IL, United States.

Clin Cancer Res 2021 Apr 22. Epub 2021 Apr 22.

Department of Pathology, The Johns Hopkins University, Baltimore, Maryland.

It is a sad fact that despite being almost completely preventable through human papillomavirus (HPV) vaccination and screening, cervical cancer remains the fourth most common cancer to affect women worldwide. Persistent high-risk HPV (hrHPV) infection is the primary etiologic factor for cervical cancer. Upward of 70% of cases are driven by HPV types 16 and 18, with a dozen other hrHPVs associated with the remainder of cases. Read More

Int J Community Based Nurs Midwifery 2021 Apr;9(2):92-105

Molecular Dermatology Research Center, Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Human papillomavirus (HPV) is the most globally-prevalent sexually-transmitted disease. Many stresses experienced by the patients after their disease is diagnosed affect the disease progression, and these problems and consequences demonstrate the importance of the support for the patients. The present research was conducted to explore the perception and experience of support in patients diagnosed with HPV. Read More

Vaccine 2021 05 6;39(20):2731-2735. Epub 2021 Apr 6.

Department of Epidemiology of Microbial Diseases, Yale School of Public Health, PO Box 208034, 60 College Street, New Haven, CT 06520-8034, USA. Electronic address:

The coronavirus disease 2019 (COVID-19) pandemic has significantly affected utilization of preventative health care, including vaccines. We aimed to assess HPV vaccination rates during the pandemic, and conduct a simulation model-based analysis to estimate the impact of current coverage and future pandemic recovery scenarios on disease outcomes. The model population included females and males of all ages in the US. Read More

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2021 May 13;64(5):590-599. Epub 2021 Apr 13.

Lehrstuhl für Epidemiologie, Fakultät für Sport- und Gesundheitswissenschaften, Technische Universität München, Georg-Brauchle-Ring 56, 80992, München, Deutschland.

Human papillomaviruses (HPVs) can cause both benign and malignant tumors. To date, more than 200 HPV types have been discovered, of which 12 are currently classified as high risk for cervical cancer. HPV types that affect the anogenital tract are sexually transmitted. Read More

Int J Dermatol 2021 Apr 7. Epub 2021 Apr 7.

Dermatology Department, Hospital Sant Joan de Déu, Barcelona, Spain.

Indian J Sex Transm Dis AIDS 2020 Jul-Dec;41(2):204-207. Epub 2020 Jul 31.

Department of Dermatology, Venereology and Leprosy, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, India.

Genital warts/condyloma acuminata is the most common mucosal human papillomavirus (HPV) infection encountered by the dermatologists. They can be asymptomatic or symptomatic. They can present as discrete lesions or confluent masses. Read More

J Am Acad Dermatol 2021 Apr 2. Epub 2021 Apr 2.

Department of Biostatistics, Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM), Université Libre de Bruxelles, Brussels, Belgium.

Asian Pac J Cancer Prev 2021 Mar 1;22(3):785-791. Epub 2021 Mar 1.

School of Science, Arts, Media and Management (SSAMM), Karunya Institute of Technology and Sciences, Karunya Nagar, Coimbatore-641 114, Tamil Nadu, India.

Background: Global trend is moving towards the use of natural phytochemicals to fight against pathogens. Human cervical cancer is directly associated with onco-potent type of Human Papilloma Virus (HPV). There is no known medicine for clearance of HPV type whose persistence is the cause of occurrence and re-occurrence of cervical cancer. Read More

Skin Therapy Lett 2021 Mar;26(2):6-8

Virginia Tech Carilion School of Medicine; Roanoke, VA, USA.

Human papillomavirus (HPV)-induced cutaneous disease is a common complaint for patients presenting for dermatology evaluation. Infection by HPV is the major etiologic factor in the development of cutaneous warts, epidermodysplasia verruciformis, and possibly a subset of cutaneous squamous cell carcinoma. Carcinoma of the genitourinary tract, most notably cervical carcinoma, is the most severe manifestation of infection with specific serotypes of HPV. Read More

Australas J Dermatol 2021 Mar 25. Epub 2021 Mar 25.

Department of Dermatology, Acharya Shree Bhikshu Hospital, Delhi, India.

Anogenital warts (AGWs) are caused by human papilloma virus (HPV) and are transmitted by sexual route. The available options for the treatment of AGWs are cumbersome, require multiple sittings and are associated with recurrence. This is a case report of a male with condyloma acuminata who was treated successfully using injection vitamin D3. Read More

Sex Med Rev 2021 Mar 19. Epub 2021 Mar 19.

Division of Urologic Surgery, Duke University Medical Center, Durham, NC, USA. Electronic address:

Introduction: Condyloma acuminata (CA) of the urethra presents a management challenge due to high recurrence rates, difficulty in accessing urethral lesions, risk of stricture formation, and potential for sexual dysfunction. While standard treatment modalities are acceptable for some external genital condyloma, they are not always feasible or appropriate for urethral lesions.

Objectives: We sought to review the literature on epidemiology, presentation, diagnosis and treatment of urothelial CA with a focus on surgical treatment options. Read More

Microb Pathog 2021 Mar 16;154:104802. Epub 2021 Mar 16.

Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Vulvovaginal candidiasis is a global issue of concern due to its association with economic costs, sexually transmitted infections, and ascending genital tract diseases. This infection affects 75% of women on at least one occasion over a lifetime. The present systematic review and meta-analysis is the first to determine the prevalence of vulvovaginal candidiasis in Iranian women. Read More

PLoS Med 2021 Mar 11;18(3):e1003534. Epub 2021 Mar 11.

Cancer Research Division, Cancer Council New South Wales, Sydney, Australia.

Background: A nonavalent human papillomavirus (HPV) vaccine has been licensed for use in women and men up to age 45 years in the United States. The cost-effectiveness of HPV vaccination for women and men aged 30 to 45 years in the context of cervical cancer screening practice was evaluated to inform national guidelines.

Methods And Findings: We utilized 2 independent HPV microsimulation models to evaluate the cost-effectiveness of extending the upper age limit of HPV vaccination in women (from age 26 years) and men (from age 21 years) up to age 30, 35, 40, or 45 years. Read More

Hum Vaccin Immunother 2021 Mar 11:1-12. Epub 2021 Mar 11.

Keck School of Medicine of USC, USC Student Health, Los Angeles, CA, USA.

Human papillomavirus (HPV) is the most common sexually transmitted infection in the world, with the ability to cause external genital warts and cancers. The HPV vaccine, first released in the United States of America (USA) in 2006, has been shown to protect against the highest risk HPV strains responsible for the majority of HPV-related cancers. In mainland China, the HPV vaccine was only recently approved in 2016 and is therefore not readily available. Read More

J Infect Dev Ctries 2021 Mar 7;15(2):297-300. Epub 2021 Mar 7.

Infectious Diseases Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.

Introduction: Ethnical segregation and migration influence sexual health. Differences in sexual networks and the risk of sexually transmitted diseases (STDs) between racial/ethnic minorities and the native population have been described in the literature.

Methodology: We collected data on sexual behavior and physical examination. Read More

Prev Med 2021 Mar 4;144:106321. Epub 2021 Mar 4.

University of Cambridge, Cambridge, United Kingdom.

Prophylactic HPV vaccination has been a great public health success. For >20 years, clinical trials were conducted with the 2-, 4-, and/or 9-valent vaccines in young-adult females, mid-adult women, males, and adolescents. In all studies, the vaccines were highly efficacious, immunogenic, and well tolerated. Read More

Life (Basel) 2021 Feb 14;11(2). Epub 2021 Feb 14.

Department of Dermatology, Military Institute of Medicine, 01-755 Warsaw, Poland.

Background: Genital warts are the manifestation of the human papillomavirus (HPV) infection, which may last for weeks or months before the clinical presentation. The primary aim of the study was the correlation of the DNA HPV genotypes eradication with the treatment response in male patients with persistent genital warts.

Methods: Twenty-one male patients (age range: 22-58) after failure of cryotherapy and podophyllotoxin treatment were enrolled in the study. Read More

Case Rep Dermatol 2021 Jan-Apr;13(1):36-41. Epub 2021 Jan 25.

Department of Dermatology, Derma Clinics, Riyadh, Saudi Arabia.

Imiquimod cream is an immunomodulatory agent that has been approved by the US Food and Drug Administration for use in the treatment of anogenital warts (condylomata acuminata) due to its local immune effects in activating Toll-like receptors 7 and 8 on antigen-presenting cells, resulting in reduction of the viral load of human papillomavirus with subsequent wart regression. After its application, some side effects are commonly reported, including erythema, edema, scaling, erosion, and ulceration. While pigmentary changes, including vitiligo-like depigmentation, have been mentioned as a possible side effect, they have rarely been reported in the literature. Read More

Rev Med Virol 2021 Mar 17;31(2):e2169. Epub 2020 Sep 17.

Laboratorio 315, Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, Mexico City, México.

While high-risk human papillomavirus (HR-HPV) infection is related to the development of cervical, vulvar, anal, penile and oropharyngeal cancer, low-risk human papillomavirus (LR-HPV) infection is implicated in about 90% of genital warts, which rarely progress to cancer. The carcinogenic role of HR-HPV is due to the overexpression of HPV E5, E6 and E7 oncoproteins which target and modify cellular proteins implicated in cell proliferation, apoptosis and immortalization. LR-HPV proteins also target and modify some of these processes; however, their oncogenic potential is lower than that of HR-HPV. Read More

PLoS One 2021 11;16(2):e0245894. Epub 2021 Feb 11.

Center for Observational and Real World Evidence, Merck & Co., Inc., Kenilworth, New Jersey, United States of America.

Background: The human papillomavirus (HPV) vaccine was introduced into Thailand's national immunization program in 2017 for 11-12 year old school girls. The objectives of this study were to examine the epidemiological consequences and cost-effectiveness of a routine quadrivalent HPV (4vHPV) vaccination and the routine 4vHPV vaccination plus 5-year catch-up vaccination by comparing with cervical cancer screening only (no vaccination) in Thailand.

Method: A transmission dynamic model was used to assess the cost-effectiveness of the routine 4vHPV vaccination and the routine 4vHPV vaccination plus catch-up vaccination, compared with no vaccination (screening only) in Thai population. Read More

Front Public Health 2020 20;8:552028. Epub 2021 Jan 20.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

Diagnosed in more than 90% of cervical cancers, the fourth deadliest cancer in women, human papillomavirus (HPV) is currently the most common pathogen responsible for female cancers. Moreover, HPV infection is associated with many other diseases, including cutaneous and anogenital warts, and genital and upper aerodigestive tract cancers. The incidence and prevalence of these pathologies vary considerably depending on factors including HPV genotype, regional conditions, the study population, and the anatomical site sampled. Read More

Andrologia 2021 May 7;53(4):e14006. Epub 2021 Feb 7.

Dermatalogy Clinic, Dragos Hospital, Bezmialem Vakıf University, İstanbul, Turkey.

The relationships between cancer caused by HPV and some vitamins, as well as leucocytes and their ratios, have been investigated in the literature. Our aim is to evaluate these relationships at the level of genital wart in terms of the investigated parameters and lesion numbers. Data were obtained from 98 and 94 patients for groups one and two, including warts patients and healthy people respectively. Read More

Photodiagnosis Photodyn Ther 2021 Mar 30;33:102204. Epub 2021 Jan 30.

Department of Dermatology, Saint-Joseph University, Beirut, Lebanon.

Background: Human papilloma virus (HPV) infection is the most common sexually transmitted disease worldwide and the main cause of genital warts. Clear recommendations for the management of urethral warts, which are often hard to detect and difficult to treat, are still lacking.

Objective: To summarize all available data describing treatment modalities of urethral warts, compare their efficacy and side effects, and provide physicians a treatment strategy outline. Read More

J Med Internet Res 2021 02 2;23(2):e21465. Epub 2021 Feb 2.

JC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.

Background: Human papillomavirus (HPV) vaccination is effective in the prevention of vaccine-type genital warts and cancers among men who have sex with men (MSM).

Objective: The primary objective of this randomized controlled trial (RCT) is to evaluate the efficacies of 2 web- and theory-based interventions with and without brief motivational interviewing (MI) over the phone to increase the completion of HPV vaccination among unvaccinated participants within a 24-month follow-up period compared with the control group.

Methods: A 3-arm parallel-group RCT was conducted between July 2017 and December 2019. Read More