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    Cost analysis of Human Papillomavirus-related cervical diseases and genital warts in Swaziland.
    PLoS One 2017 22;12(5):e0177762. Epub 2017 May 22.
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
    Background: Human papillomavirus (HPV) has proven to be the cause of several severe clinical conditions on the cervix, vulva, vagina, anus, oropharynx and penis. Several studies have assessed the costs of cervical lesions, cervical cancer (CC), and genital warts. However, few have been done in Africa and none in Swaziland. Read More

    HPV entry into cells.
    Mutat Res 2017 Apr - Jun;772:13-22. Epub 2016 Sep 23.
    Department of Biological Sciences, Fordham University, Bronx, NY, USA. Electronic address:
    Human papillomavirus (HPV) is a sexually transmitted virus responsible for the development of cervical cancer, anal cancer, head and throat cancers, as well as genital area warts. A major focus of current HPV research is on preventing the virus from entering a cell and transferring its genetic material to the nucleus, thus potentially preventing the development of cancer. Although the available HPV vaccines are extremely successful, approximately 15 additional cancer-causing HPVs have been identified that the vaccines do not protect against. Read More

    Dysplasia of Granulocytes in a Patient with HPV Disease, Recurrent Infections, and B Lymphopenia: A Novel Variant of WHIM Syndrome?
    Front Pediatr 2017 2;5:95. Epub 2017 May 2.
    Department of Medicine of Systems, University of Rome Tor Vergata, Rome, Italy.
    WHIM syndrome is a condition in which affected persons have chronic peripheral neutropenia, lymphopenia, abnormal susceptibility to human papilloma virus infection, and myelokathexis. Myelokathexis refers to the retention of mature neutrophils in the bone marrow (BM), which accounts for degenerative changes and hypersegmentation. Most patients present heterozygous autosomal dominant mutations of the gene encoding CXCR4. Read More

    A Comparative Study of Liquid Nitrogen Cryotherapy as Monotherapy versus in Combination with Podophyllin in the Treatment of Condyloma Acuminata.
    J Clin Diagn Res 2017 Mar 1;11(3):WC01-WC05. Epub 2017 Mar 1.
    Junior Resident, Department of Dermatology, Government Medical College, Amritsar, Punjab. India.
    Introduction: Condyloma Acuminata (CA) is a common viral sexually transmitted disease. Although various treatment modalities are available for treating CA, but none of them can achieve 100% response rate. In a search for better response rate and less recurrence rate, the combination of cytotoxic agent Podophyllin with ablative liquid nitrogen cryotherapy was evaluated over cryotherapy alone. Read More

    Effectiveness of HPV vaccines against genital warts in women from Valencia, Spain.
    Vaccine 2017 Jun 9;35(25):3342-3346. Epub 2017 May 9.
    Universidad Católica de Valencia 'San Vicente Mártir', C/ Espartero, 7, 46007 Valencia, Spain; Vaccine Research Unit, Fundación para el Fomento de la Investigación Sanitaria y Biomédica (FISABIO), Avda. Catalunya 21, 46020 Valencia, Spain. Electronic address:
    Objectives: To assess the effectiveness of the HPV vaccines in preventing genital warts in young women.

    Design: Population-based study using health databases.

    Setting: Valencian Community (Spain). Read More

    Impact of Number of Human Papillomavirus Vaccine Doses on Genital Warts Diagnoses Among a National Cohort of U.S. Adolescents.
    Sex Transm Dis 2017 Jun;44(6):365-370
    From the * Boston Medical Center, Boston University School of Medicine; †Veterans Affairs Boston Healthcare System, Boston University School of Medicine, Boston, MA; and ‡Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC.
    Background: The impact of fewer than 3 doses of human papillomavirus (HPV) vaccine on genital warts is uncertain.

    Methods: Using the Truven Health Analytics Marketscan administrative database, we compared rates of genital warts among women receiving 0, 1, 2, or 3 doses of HPV vaccine. Females aged 9 to 18 years on January 1, 2007, who were continuously enrolled in the database through December 31, 2013, were included. Read More

    Virus-Induced Cancers of the Skin and Mucosa: Are We Dealing with "Smoking Guns" or "Smoke and Mirrors" in the Operating Theatre?
    Dermatol Ther (Heidelb) 2017 May 8. Epub 2017 May 8.
    Department of Otorhinolaryngology and Head and Neck Surgery, Bielefeld University Hospital, Teutoburger Strasse 50, 33604, Bielefeld, Germany.
    Introduction: Human papillomavirus (HPV) alone is thought to cause ~610,000 cases of cancer per year, and is the dominant aetiological agent for ano-genital (esp. cervical) and head and neck cancers (esp. oropharyngeal). Read More

    Traditional Chinese medicine for human papillomavirus (HPV) infections: A systematic review.
    Biosci Trends 2017 May 6. Epub 2017 May 6.
    Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, IBS, Shanghai Medical College, Fudan University.
    Human papillomavirus (HPV) infections are common and generally harmless, but persistent infections can bring health problems like cancer and genital warts. For the uninfected group, HPV vaccines provide safe and effective protection, but they're type-restricted and expensive. For those infected, so far there have been a handful of treatments for HPV-associated benign or malignant diseases, traditional Chinese medicine being one of them. Read More

    Prevalence of HPV in Adults Aged 18-69: United States, 2011-2014.
    NCHS Data Brief 2017 Apr(280):1-8
    Key Findings: Data from the National Health and Nutrition Examination Survey Human papillomavirus (HPV) is the most common sexually transmitted infection in the United States (1). Some HPV types can cause genital warts and are considered low risk, with a small chance for causing cancer. Other types are considered high risk, causing cancer in different areas of the body including the cervix and vagina in women, penis in men, and anus and oropharynx in both men and women (2). Read More

    [One decade of HPV vaccination in Germany].
    Urologe A 2017 Apr 28. Epub 2017 Apr 28.
    Urologische Klinik, Klinikum Memmingen, Bismarckstraße 23, 87700, Memmingen, Deutschland.
    As a worldwide very common sexually transmitted infection (STI), HPV causes millions of genital warts every year and is responsible for 5% of all cancers in men and women. With strong empirical evidence for both vaccine safety and efficacy, the HPV vaccines proved to protect against these HPV-related conditions over the last decade. But current HPV vaccination coverage is suboptimal in many countries. Read More

    Clinico-epidemiological profile of patients attending Suraksha Clinic of tertiary care hospital of North India.
    Indian J Sex Transm Dis 2017 Jan-Jun;38(1):54-59
    Department of Skin and STD, Government Medical College, Amritsar, Punjab, India.
    Background: Sexually transmitted infections (STIs) are a global health problem. Trends of STIs vary from place to place depending on various epidemiological factors prevailing in that respective geographic area.

    Aims And Objectives: The present study was conducted to find the pattern and prevalence of different STIs out of total STI clinic attendees, to identify any change in the trend of STIs, various epidemiological factors, and behavior of individual diseases. Read More

    Study of prevalence of sexually transmitted infections/human immunodeficiency virus and condom use among male-to-female transgender: A retrospective analysis from a tertiary care hospital in Chennai.
    Indian J Sex Transm Dis 2017 Jan-Jun;38(1):43-46
    Institute of Venereology, Madras Medical College, Chennai, Tamil Nadu, India.
    Context: A "Transgender" person is one who dresses as, desires to be, has undergone surgery to become or identifies with opposite sex. They have a higher risk of sexually transmitted infection (STI) due to a combination of biological and social reasons. They have risky sexual behaviors but low-risk perception. Read More

    Skin manifestations among GATA2-deficient patients.
    Br J Dermatol 2017 Apr 25. Epub 2017 Apr 25.
    Dermatology Department, CHU Rennes, Rennes, France.
    GATA2 mutations have been identified in various diseases, such as monoMAC syndrome, Emberger syndrome, familial myelodysplastic syndrome, acute myeloid leukemia, and dendritic cell, monocyte, B and NK cell deficiency. These syndromes present a wide range of clinical features, dominated by severe infections and haematological disorders such as myelodysplastic syndrome. Up to 70% of GATA2-mutated patients have dermatological features, mainly genital or extra-genital warts, panniculitis or erythema nodosum, and lymphedema. Read More

    Comparative study of p16 protein expression in squamous cell carcinomas from patients with epidermodysplasia verruciformis and patients without the disease.
    Arch Dermatol Res 2017 Apr 24. Epub 2017 Apr 24.
    Department of Dermatology, University of São Paulo Medical School, Avenida Dr. Arnaldo, 455, São Paulo, SP, 01246-903, Brazil.
    Epidermodysplasia verruciformis (EV) is a rare genodermatosis associated with susceptibility to beta-human papilloma virus (HPV) infection. EV patients develop disseminated warts and non-melanoma skin cancer, mainly squamous cell carcinomas (SCC) that are locally aggressive. EV pathogenesis is not yet fully understood, but alterations in the p16 gene play a role in the pathogenesis of neoplasms caused by high-risk genital HPV. Read More

    Condyloma-like lesions in a young woman: Not always synonym of genital warts.
    Eur J Obstet Gynecol Reprod Biol 2017 Jun 8;213:142-143. Epub 2017 Apr 8.
    Department of Dermatology, Hospital Universitario 12 de Octubre, Instituto de Investigación I+12, Madrid, Spain. Electronic address:

    Estimation of the overall burden of cancers, precancerous lesions, and genital warts attributable to 9-valent HPV vaccine types in women and men in Europe.
    Infect Agent Cancer 2017 11;12:19. Epub 2017 Apr 11.
    Cancer Epidemiology Research Program, Institut Català d'Oncologia (ICO)-IDIBELL, L'Hospitalet de Llobregat, Catalonia Spain.
    Background: In addition to cervical cancer, human papillomavirus (HPV) is responsible for a significant proportion of cancers and precancerous lesions of the vulva, vagina, anus, penis, head and neck, as well as genital warts. We estimated the annual number of new cases of these diseases attributable to 9-valent HPV vaccine types in women and men in Europe.

    Methods: The annual number of new cancers of the cervix, vulva, vagina, anus, penis, and selected head and neck sites in the population of the European Medicines Agency territory was estimated based on age-specific incidence rates extracted from Cancer Incidence in 5 Continents, Volume X and Eurostat population data for 2015. Read More

    HPV-related external genital lesions among men residing in Brazil.
    Braz J Infect Dis 2017 Apr 8. Epub 2017 Apr 8.
    Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Instituto do Câncer do Estado de São Paulo, Center for Translational Investigation in Oncology, São Paulo, SP, Brazil; Universidade de São Paulo Faculdade de Medicina, Departamento de Radiologia e Oncologia São Paulo, SP, Brazil. Electronic address:
    The aims of this study were to determine the incidence of external genital lesions (EGLs), specifically histologically confirmed condyloma (genital warts) and Penile Intraepithelial Neoplasia (PeIN), and genital HPV infection progression to EGLs among healthy men aged 18-73 residing in Brazil. Subjects included 1118 men enrolled in the HPV Infection in Men (HIM) study between July 2005 and June 2009. At each visit, EGLs were biopsied and subjected to pathological evaluation. Read More

    Skin diseases of the vulva: Infectious diseases.
    J Obstet Gynaecol 2017 Apr 11:1-9. Epub 2017 Apr 11.
    a Department of Dermatology , Bispebjerg Hospital , Copenhagen , Denmark.
    A multitude of infectious diseases of viral (genital herpes, herpes zoster, genital warts and molluscum contagiosum), bacterial (syphilis, chancroid, lymphogranuloma venereum, donovanosis, erysipelas, cellulitis and necrotising fasciitis, folliculitis, impetigo, bartholin gland abscess, trichomycosis and erythrasma), fungal (candidiasis and dermatophytosis) and parasitic (pediculosis pubis) origin may affect the vulvar area. Herein, we review the infections and their skin manifestations in the vulvar area. Read More

    Concordance of HPV-DNA in cervical dysplasia or genital warts in women and their monogamous long-term male partners.
    J Med Virol 2017 Apr 8. Epub 2017 Apr 8.
    Department of Dermatovenereology, Bulovka Hospital, 2nd Medical Faculty Charles University, Prague, Czech Republic.
    Transmission of human papillomavirus (HPV) is a premise for development of cervical dysplasia and genital warts (GWs). This cross-sectional study assesses concordance of HPV types present in GWs or cervical dysplasia in women and genital infection of their monogamous male partners in conjunction with seroprevalence of HPV-6, -11, -16, and -18 antibodies. Blood was taken from both women and men, as well a smear of the urogenital area of men. Read More

    Decline in hospitalization for genital warts in the Veneto region after an HPV vaccination program: an observational study.
    BMC Infect Dis 2017 Apr 5;17(1):249. Epub 2017 Apr 5.
    Institute of Hygiene, Laboratory of Public Health and Population Studies, University of Padua, Via Loredan 18, 35121, Padua, Italy.
    Background: Human papillomavirus (HPV) is one of the most common sexually transmitted pathogens. This observational study was conducted to estimate the trend of hospitalization for genital warts (GWs) in the Veneto region (Italy) from 2004 to 2015.

    Methods: All patients with GWs were identified in the hospital discharge records of all public and accredited private hospitals that related to Veneto residents and contained the ICD9-CM code 078. Read More

    Vulvar condylomatosis after sex reassignment surgery in a male-to-female transsexual: Complete response to imiquimod cream.
    Gynecol Oncol Rep 2017 May 18;20:75-77. Epub 2017 Mar 18.
    Department of Plastic and Reconstructive Surgery, Institute of Plastic Surgery Dr. Ivan Mañero, Barcelona, Spain.
    Background: The number of patients seeking sex reassignment surgery is increasing. Approximately 1:30,000 adult males and 1: 100,000 adult females seek this procedure. Neovaginal-related disorders after sex reassignment surgery are increasingly more common. Read More

    Heat-Induced Editing of HPV Genes to Clear Mucocutaneous Warts?
    J Invest Dermatol 2017 Apr;137(4):796-797
    Dermatology and Academic Wound Healing, Division of Infection and Immunity, School of Medicine, College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK. Electronic address:
    Hyperthermia increases expression of the antiviral cellular factors APOBEC3A and APOBEC3G and induces G-to-A or C-to-T mutations in human papilloma virus cervical cell lines and genital warts. This unexpected effect of heat treatment correlated with regression of genital warts in a subset of patients, including at distant sites, suggesting that this effect may be mediated in part by antiviral as well as immunological mechanisms. Read More

    Trends in genital warts diagnoses in New Zealand five years following the quadrivalent human papillomavirus vaccine introduction.
    N Z Med J 2017 Mar 24;130(1452):9-16. Epub 2017 Mar 24.
    Foundation Year Two Doctor, Taunton and Somerset Foundation Trust, UK.
    Aim: To investigate whether changes in rates of genital warts diagnosis at Auckland Sexual Health Service (ASHS), pre and post the quadrivalent human papillomavirus (4vHPV) vaccine introduction in late 2008, differed between clients vaccine-eligible and not eligible.

    Method: All new clients attending ASHS from 2007 to 2013 were categorised as having genital warts or not. Generalised linear mixed models were used to compare differences in rates of change in diagnoses. Read More

    The burden of HPV-related diseases in Italy, 2001-12.
    J Public Health (Oxf) 2017 Mar 14:1-8. Epub 2017 Mar 14.
    Postgraduate School of Hygiene and Preventive Medicine, University of Ferrara, 44121 Ferrara, Italy.
    Background: Human papillomavirus (HPV) infection is the main cause of cervical cancer and plays a relevant role in the development of genital warts and of the cancer of penis and anus, head/neck, oropharynx and genitourinary system. The aim of this study is the evaluation of hospitalizations due to HPV-related pathologies in 2001-12 in Italy.

    Methods: The national hospital discharge forms were provided by the Ministry of Health. Read More

    Human papillomavirus vaccination and genital warts in young Indigenous Australians: national sentinel surveillance data.
    Med J Aust 2017 Mar;206(5):204-209
    The Kirby Institute, University of New South Wales, Sydney, NSW.
    Objectives: To examine the impact of the national human papillomavirus (HPV) vaccination program (available to girls and women [12-26 years] since 2007 and to boys [12-15 years] since 2013) on the number of diagnoses of genital warts in Australian Aboriginal and Torres Strait Islander (Indigenous) people.

    Design, Setting, Participants: Analysis of routinely collected data from patients attending 39 sexual health clinics (SHCs) in the Genital Warts Surveillance Network for the first time.Major outcome: The average annual proportion of Indigenous and non-Indigenous SHC patients diagnosed with genital warts during the pre-vaccination (2004-2007) and vaccination periods (2008-2014), stratified by age group and sex. Read More

    "We've Been Together. We Don't Have It. We're Fine." How Relationship Status Impacts Human Papillomavirus Vaccine Behavior among Young Adult Women.
    Womens Health Issues 2017 Mar - Apr;27(2):228-236. Epub 2016 Oct 27.
    Department of Community and Family Health, College of Public Health, University of South Florida, Tampa, Florida.
    Background: Vaccination against the human papillomavirus (HPV) has the potential to significantly reduce morbidity and mortality associated with genital warts and HPV-related cancers. However, HPV vaccination rates continue to be suboptimal among the "catch-up" population of 18- to 26-year-old women. One consistent risk factor for nonvaccination is being in a relationship. Read More

    Ano-Genital Warts and HIV Status- A Clinical Study.
    J Clin Diagn Res 2017 Jan 1;11(1):WC01-WC04. Epub 2017 Jan 1.
    Assistant Professor, Center for Interdisciplinary Research, D.Y. Patil University , Kolhapur, Maharastra, India .
    Introduction: Ano-Genital Warts (AGW) like other Sexually Transmitted Diseases (STD) is associated with Human Immunodeficiency Virus (HIV) infection. This study of AGW was done in HIV positive and HIV negative patients.

    Aim: To study the risk factors and clinical presentations of ano-genital warts in HIV positive and negative patients. Read More

    Pulsed Dye Laser Therapy in the Treatment of Warts: A Review of the Literature.
    Dermatol Surg 2017 Apr;43(4):485-493
    *Department of Dermatology, University College London Hospital, London, United Kingdom; †Department of Dermatologic Surgery and Laser Unit, St. John's Institute of Dermatology, St. Thomas' Hospital, London, United Kingdom.
    Background: Warts or verrucae vulgaris are common cutaneous infections with currently no definitive curative treatments available.

    Objective: To determine the efficacy of pulsed dye laser (PDL) in the treatment of warts.

    Materials And Methods: A literature search was performed using the PubMed and MEDLINE databases. Read More

    The presence of human papillomavirus in semen does not affect the integrity of sperm DNA.
    Andrologia 2017 Mar 6. Epub 2017 Mar 6.
    Unit of Genetics, Department of Biology, Universidad Autónoma de Madrid, Madrid, Spain.
    It remains unknown whether human papillomaviruses (HPVs) in semen affect sperm DNA integrity. We investigated whether the presence of these viruses in semen was associated with an elevated sperm DNA fragmentation index. Semen samples of 22 normozoospermic patients undergoing infertility treatment, nine fertile donors and seven fertile men with a risk of HPV infection (genital warts or condylomas) were included in the study. Read More

    [Interferon in combined therapy of human papillomavirus infections associated with sexually transmitted infections. linical observation].
    Urologiia 2016 Nov(5):103-108
    Moscow Regional Clinical Center of Skin and Sexually-Transmitted Diseases, Moscow.
    To investigate the effectiveness of Ingaron (interferon-) in the treatment of HPV infection associated with sexually transmitted infections, the authors analyzed the scientific literature on the association of human papillomavirus infection with other viral and microbial pathogens. A clinical case of the association of human papillomavirus infection, urogenital infections (urogenital chlamydia and genital herpes) and localized scleroderma penis is described. The results of integrated therapy of diseases with the help of Interferon-gamma have been presented. Read More

    [Anogenital warts: a new way of solving the common problem of urology (results of long-term follow-up)].
    Urologiia 2016 Nov(5):47-51
    Samara Regional Center for Prevention and Control of AIDS and Infectious Diseases.
    Aim: To evaluate the effectiveness of combined use of the imiquimod 5% cream and vaccination against human papillomavirus (HPV) using a quadrivalent recombinant vaccine to achieve long-term clinical remission of chronic HPV infection manifested by anogenital warts.

    Material And Methods: The study comprised 36 patients, including 22 men, aged 26.4+/-4. Read More

    Human papilloma virus dermatosis in human immunodeficiency virus-positive patients: A 14-year retrospective study in 965 patients.
    Med Clin (Barc) 2017 May 21;148(9):401-404. Epub 2017 Feb 21.
    Universidad Rey Juan Carlos, Madrid, España; Servicio de Medicina Preventiva, Hospital Universitario Rey Juan Carlos, Móstoles, Madrid, España.
    Introduction: The incidence of the human papilloma virus (HPV) has not dropped in HIV-positive patients despite the discovery of antiretroviral therapy (ART). Our goal is to assess the prevalence of HPV in HIV patients and its relationship with the epidemiological and virological characteristics of HIV patients.

    Patients And Methods: Retrospective cohort of 965 patients diagnosed with HIV from 1998 to 2012. Read More

    Lichen planus hypertrophicus of the vulva - a rare entity.
    Int J STD AIDS 2017 Jan 1:956462417695052. Epub 2017 Jan 1.
    Department of Dermatology, St John's Medical College, Bangalore, India.
    Vulvovaginal lichen planus is a type of chronic inflammatory dermatosis of the vulva, usually seen as a part of widespread lichen planus. The common clinical types of vulval lichen planus include papulosquamous, erosive and pigmented types. Hypertrophic lichen planus of the vulva is a rare entity. Read More

    Sexual health of women aged 40 and over attending an inner city integrated sexual health clinic.
    Int J STD AIDS 2017 Mar 20;28(4):404-407. Epub 2016 Dec 20.
    Department of GUM/HIV, King's College Hospital NHS Foundation Trust, London, UK.
    Sexual health policy remains focussed on younger adults. However, rates of sexually transmitted infections (STIs) in older people continue to increase. We explored the sexual healthcare needs of women aged 40 and over attending an integrated sexual health clinic in South London. Read More

    Common Skin Conditions in Children: Skin Infections.
    FP Essent 2017 Feb;453:26-32
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Skin infections account for a significant subset of dermatologic conditions of childhood. Common cutaneous viral infections in children include warts, molluscum contagiosum, hand-foot-and-mouth disease, and herpes simplex. Although viral infections are self-limited and often only mildly symptomatic, they can cause anxiety, embarrassment, and health care use. Read More

    Perceptions of HPV and attitudes towards HPV vaccination amongst men who have sex with men: A qualitative analysis.
    Br J Health Psychol 2017 May 13;22(2):345-361. Epub 2017 Feb 13.
    Brighton and Sussex Medical School, UK.
    Objectives: Men who have sex with men (MSM) are at risk of genital warts and anal cancer due to human papillomavirus (HPV) infection. This study explores MSMs' perceptions of HPV and HPV vaccination prior to the introduction of this programme.

    Design: Focus groups and one-to-one interviews with self-identified MSM were conducted between November 2014 and March 2015 in Brighton, UK. Read More

    The clinical and economic benefits of school-based quadrivalent HPV vaccination in Singapore.
    Int J Gynaecol Obstet 2017 May 10;137(2):129-137. Epub 2017 Mar 10.
    Center for Observational and Real World Evidence, Merck, Kenilworth, NJ, USA.
    Objective: To investigate the clinical and economic impacts of school-based administration of the quadrivalent HPV vaccine.

    Methods: A retrospective health-economic analysis was conducted using data collected in Singapore between 2004 and 2005. A dynamic transmission model was adapted for universal vaccination that provided 80% coverage among students aged 11-12 years. Read More

    Sexually transmitted infection prevalence and related risk factors among heterosexual male methamphetamine users in China.
    Int J STD AIDS 2017 Jan 1:956462417693165. Epub 2017 Jan 1.
    4 Department of Dermatology, The Third hospital of Chengyang, Qingdao, China.
    Few studies have examined the association between methamphetamine (MA) abuse and sexually transmitted infection (STI) risk among heterosexual male MA users in China. A total of 288 heterosexual male MA users who met our inclusion criteria were recruited from nightclubs, KTVs, bars, bath centres and an STI clinic. STIs were screened among the participants, and the risk factors related to STIs were analysed by multivariate logistic regression in SPSS 11. Read More

    Prevalence and incidence of external genital warts in a sample of Italian general female population.
    BMC Infect Dis 2017 Feb 6;17(1):126. Epub 2017 Feb 6.
    HPV-unit, Istituto Nazionale Tumori Regina Elena, Via Elio Chianesi 53, Rome, Italy.
    Background: The Human papillomavirus is the most common sexually transmitted virus worldwide. The objective of this study was to estimate: 1) the prevalence and the incidence of external genital warts (eGW) in a sample of women attending community outpatient clinics and 2) the total number of eGW cases in the Italian female population aged 15-64 years.

    Methods: A prospective study was performed for a 12-month period between 2009 and 2010, among a sample of women attending community gynecological outpatient clinics located throughout Italy. Read More

    [Genital warts in HIV-infected individuals].
    Hautarzt 2017 Mar;68(3):192-198
    Klinik für Dermatologie, Venerologie und Allergologie, HELIOS St. Elisabeth Klinik Oberhausen, Universität Witten-Herdecke, 46045, Oberhausen, Deutschland.
    Anogenital warts (condylomata acuminata) are much more frequent in human immunodeficiency (HIV)-positive patients compared to HIV-negative individuals. Anogenital warts of HIV-infected patients differ from those of HIV-negative individuals with respect to their spread, occurrence on more unusual anatomical sites, human papillomavirus (HPV)-type spectrum, tendency to recur, and risk of malignant transformation. Between 18 and 56% of anogenital warts of HIV-positive patients harbor high-grade dysplasia. Read More

    Health economic evaluation of Human Papillomavirus vaccines in women from Venezuela by a lifetime Markov cohort model.
    BMC Public Health 2017 Feb 2;17(1):152. Epub 2017 Feb 2.
    IECS Instituto de Efectividad Clínica y Sanitaria, Dr. Emilio Ravignani 2024 (C1014CPV), 1014, Buenos Aires, Argentina.
    Background: Cervical cancer (CC) and genital warts (GW) are a significant public health issue in Venezuela. Our objective was to assess the cost-effectiveness of the two available vaccines, bivalent and quadrivalent, against Human Papillomavirus (HPV) in Venezuelan girls in order to inform decision-makers.

    Methods: A previously published Markov cohort model, informed by the best available evidence, was adapted to the Venezuelan context to evaluate the effects of vaccination on health and healthcare costs from the perspective of the healthcare payer in an 11-year-old girls cohort of 264,489. Read More

    Four sexually transmitted infections (STIs) in Belgian general practice: first results (2013-2014) of a nationwide continuing surveillance study.
    BMJ Open 2017 Jan 27;7(1):e012118. Epub 2017 Jan 27.
    Department of Health Services Research, Scientific Institute of Public Health, Brussels, Belgium.
    Objectives: To describe and explore data from the surveillance of chlamydia, syphilis, gonorrhoea and genital warts by the Belgian Network of Sentinel General Practices (SGP) over the first 2 years (2013 and 2014) and to estimate the incidence of these 4 sexually transmitted infections (STIs). A special focus is put on data quality.

    Design: Retrospective observational study. Read More

    No evidence for cross-protection of the HPV-16/18 vaccine against HPV-6/11 positivity in female STI clinic visitors.
    J Infect 2017 Apr 23;74(4):393-400. Epub 2017 Jan 23.
    Center for Infectious Disease Control, National Institute for Public Health and the Environment, P.O. Box 1, 3720 BA Bilthoven, The Netherlands. Electronic address:
    Objectives: Data from a vaccine trial and from post-vaccine surveillance in the United Kingdom have suggested that the bivalent HPV-16/18 vaccine offers cross-protection against HPV-6/11 and protection against anogenital warts (AGW). We studied the effect of the bivalent vaccine on genital HPV-6/11 positivity and AGW in the Netherlands.

    Methods: We included all vaccine-eligible women from the PASSYON study, a biennial cross-sectional study among 16- to 24-year-old sexually transmitted infection (STI) clinic attendants. Read More

    Ranpirnase eradicates human papillomavirus in cultured cells and heals anogenital warts in a Phase I study.
    Antivir Ther 2017 Jan 25. Epub 2017 Jan 25.
    Tamir Biotechnology, Inc., Clinical Development, San Diego, CA, USA.
    Background: Human papillomaviruses (HPV), the causative agents of anogenital warts, are the most prevalent sexually transmitted infectious agents, and wart treatment poses a persistent challenge. We assessed the safety and efficacy of treating HPV with ranpirnase, an endoribonuclease from the northern leopard frog that has been used extensively in Phase III oncology trials.

    Methods: As initial verification of ranpirnase antiviral activity, we assessed its ability to eliminate papillomaviruses in cultured cells. Read More

    Should Female Partners of Men With Non-Gonococcal Urethritis, Negative for Chlamydia trachomatis and Mycoplasma genitalium, Be Informed and Treated? Clinical Outcomes From a Partner Study of Heterosexual Men With NGU.
    Sex Transm Dis 2017 Feb;44(2):126-130
    From the *Melbourne Sexual Health Centre, Alfred Health, Carlton; and †Central Clinical School, Monash University, Clayton, Victoria, Australia.
    Background: To determine if female partners of men with pathogen-negative non-gonococcal urethritis (NGU) are at risk of genital infection.

    Methods: Secondary data analysis using health records from a large sexually transmitted disease clinic in Melbourne of 1710 men and their female partners attending on the same day from January 2006 to April 2015. Proportions of female partners with symptoms suggesting genital infection or pelvic inflammatory disease (PID) were determined for: (1) men with NGU and no Chlamydia trachomatis or Mycoplasma genitalium (referred to as pathogen-negative NGU) (n = 91); 2) men with urethral C. Read More

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