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    Dynamics of HPV Viral Loads Reflect the Treatment Effect of Photodynamic Therapy in Genital Warts.
    Photodiagnosis Photodyn Ther 2017 Nov 15. Epub 2017 Nov 15.
    Department of Dermatology and Venereology, Nanfang hospital, Southern Medical University, Guangzhou, 510515, China. Electronic address:
    Background: Photodynamic therapy (PDT) has demonstrated good clinical cure rates and low recurrence rates in the treatment of genital warts. Human papillomavirus (HPV) genotypes and viral load assays can reflect the status of persistent or latent infection and serve as a predictor of infection clearance.

    Methods: Specimens from 41 patients with HPV infection were obtained, and the HPV genotypes and viral load were analyzed using real-time polymerase chain reaction (PCR) assays. Read More

    Presence of infection and analysis of HPV subtypes in girls younger than 9 years old attended at a referral service in Espírito Santo, Brazil.
    J Med Virol 2017 Nov 16. Epub 2017 Nov 16.
    Núcleo de Genética Humana e Molecular - Departamento de Ciências Biológicas - Centro de Ciências Humanas e Naturais - Universidade Federal do Espírito Santo. Address: Avenida Fernando Ferrari, 514, Goiabeiras 29075-910 - Vitória - Espírito Santo, Brazil.
    Purpose: Human papillomavirus is found in adults and adolescents and is associated with genital warts and cervical cancer. However, it has been detected in girls younger than 10 years old. Currently, there are no prevention methods for this age group, since it is not considered a risk group. Read More

    A Prospective Study of the Incidence of Juvenile-Onset Recurrent Respiratory Papillomatosis After Implementation of a National HPV Vaccination Program.
    J Infect Dis 2017 Nov 9. Epub 2017 Nov 9.
    National HPV Vaccination Program Register, VCS, East Melbourne.
    Background: Recurrent respiratory papillomatosis is a rare but morbid disease caused by human papillomavirus (HPV) types 6 and 11. Infection is preventable through HPV vaccination. Following an extensive quadrivalent HPV vaccination program (females 12-26 years in 2007-2009) in Australia, we established a method to monitor incidence and demographics of juvenile-onset recurrent respiratory papillomatosis (JORRP) cases. Read More

    Multimodal Counseling Interventions: Effect on Human Papilloma Virus Vaccination Acceptance.
    Healthcare (Basel) 2017 Nov 6;5(4). Epub 2017 Nov 6.
    Department of Interdisciplinary Sciences, A. T. Still University, Mesa, AZ 85026, USA.
    Human papilloma virus (HPV) vaccine was developed to reduce HPV-attributable cancers, external genital warts (EGW), and recurrent respiratory papillomatosis. Adolescent HPV vaccination series completion rates are less than 40% in the United States of America, but up to 80% in Australia and the United Kingdom. Population-based herd immunity requires 80% or greater vaccination series completion rates. Read More

    [A man with strange genital warts].
    Ned Tijdschr Geneeskd 2017 ;161(0):D1715
    Catharina Ziekenhuis, afd. Dermatologie, Eindhoven.
    A 36-year-old man came to the outpatient dermatology department with asymptomatic, skin-coloured to white/yellow, firm papules on his prepuce. Over the last 10 years he had received different treatments for condylomata accuminata, with no effect. After shave excision, the diagnosis of idiopathic calcinosis cutis was made. Read More

    Burden of Disease of Human Papillomavirus (HPV): Hospitalizations in the Marche and Veneto Regions. An observational study.
    Clin Drug Investig 2017 Oct 28. Epub 2017 Oct 28.
    Hygiene and Public Health Unit, Department of Cardiac, Thoracic and Vascular Sciences, Institute of Hygiene, University of Padua, Via Loredan, 18, 35121, Padova, Italy.
    Background And Objectives: HPV (human papillomavirus) is the virus most often responsible for sexually transmitted infections. The burden of HPV-related diseases on hospital resources represents a major public health problem. The aim of this study was to assess the economic burden of HPV-related diseases (anal cancer, genital cancer, genital warts, oropharyngeal cancer) on hospital resources in two Italian regions. Read More

    Monitoring the impact of HPV vaccine in males-Considerations and challenges.
    Papillomavirus Res 2016 Dec 17;2:106-111. Epub 2016 May 17.
    University of British Columbia and BC Women's Hospital and Health Centre, 4500 Oak Street, Vancouver, BC, Canada V6H 3N1.
    In this article, we examine the issues involved if national or sub-national programs are considering extending post HPV vaccine introduction monitoring to include males. Vaccination programs are now being extended to include males in some countries, in order to improve population level HPV infection control and to directly prevent HPV-related disease in males such as anogenital warts and anal cancers. Coverage and adverse events surveillance are essential components of post-vaccination monitoring. Read More

    HPV knowledge, burden and genital wart location among heterosexually identified versus homosexually identified men who have sex with men in Lima, Peru: cross-sectional results from a cohort study.
    BMJ Open 2017 Oct 24;7(10):e017338. Epub 2017 Oct 24.
    Department of Social Medicine and Population Health, Center for Healthy Communities, School of Medicine, University of California, Riverside, California, USA.
    Objectives: The relationship between sexual practices, identity and role among Latino men who have sex with men (MSM) and HIV risk is the subject of ongoing investigation but less is known about how these aspects of sexuality relate to human papilloma-virus (HPV), an independent risk factor for HIV. This observational study investigated the relationship between HPV and sexual practices, identity and role as well as other sexually transmitted infection (STI)/HIV risk factors among HIV-negative heterosexually and homosexually identified Peruvian MSM.

    Setting: Community-based clinic for MSM in Lima, Peru. Read More

    The prevalence and concordance of human papillomavirus infection in different anogenital sites among men and women in Liuzhou, China: A population-based study.
    Int J Cancer 2017 Oct 24. Epub 2017 Oct 24.
    State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Strait Collaborative Innovation Center of Biomedicine and Pharmaceutics, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China.
    Human papillomavirus (HPV) infection is the pathogenesis of anogenital cancers and genital warts in both men and women, whereas there is a scarcity of large studies focused on HPV prevalence in different anogenital sites of both sexes in the same population. From May to July 2014, 2,309 men and 2,378 women aged 18-55 were enrolled from communities in Liuzhou, China. Penis/glans penis/coronary sulcus (PGC) and perianal/anal canal (PA) specimens of men, and vaginal (VA), vulvar (VU) and PA specimens of women, were collected and genotyped for HPV. Read More

    Awareness and Knowledge Levels of 18-Year-Old and Older Individuals Regarding Human Papillomavirus (HPV) and HPV Vaccine in Hatay, Turkey.
    J Cancer Educ 2017 Oct 23. Epub 2017 Oct 23.
    Faculty of Medicine, Department of Radiation Oncology, Mustafa Kemal University, Antakya, Hatay, Turkey.
    The aim of this study was to evaluate the knowledge and awareness levels of 18-year-old and older women and men on HPV infection, HPV vaccine, and the potential risk factors in Hatay, Turkey. In our study, it was found that overall 27.0 and 23. Read More

    Random Network Models to Predict the Long-Term Impact of HPV Vaccination on Genital Warts.
    Viruses 2017 Oct 16;9(10). Epub 2017 Oct 16.
    Departamento de Ciencias de la Computación, Arquitectura de Computadores, Lenguajes y Sistemas Informáticos, Estadística e Investigación Operativa, Universidad Rey Juan Carlos, Móstoles, 28933 Madrid, Spain.
    The Human papillomaviruses (HPV) vaccine induces a herd immunity effect in genital warts when a large number of the population is vaccinated. This aspect should be taken into account when devising new vaccine strategies, like vaccination at older ages or male vaccination. Therefore, it is important to develop mathematical models with good predictive capacities. Read More

    Treatment With Quadrivalent Human Papillomavirus Vaccine for Juvenile-Onset Recurrent Respiratory Papillomatosis: Case Report and Review of the Literature.
    J Pediatric Infect Dis Soc 2017 Aug 8. Epub 2017 Aug 8.
    Vaccine Education Center.
    Although juvenile-onset recurrent respiratory papillomatosis (JoRRP) generally involves a benign tumor on the larynx and other respiratory tract areas, almost all patients with this disease require repeated surgical intervention (to prevent airway obstruction during the course of illness) and various adjuvant therapies such as interferon, cidofovir, acyclovir, ribavirin, indole-3-carbinol, HspE7, mumps vaccine, photodynamic therapy, propranolol, cimetidine, and bevacizumab. Some case reports recently described the effectiveness of the quadrivalent human papillomavirus vaccine (HPV4) as an adjuvant therapy. On the basis of these reports, we administered HPV4 to a 2-year-old boy with JoRRP. Read More

    Estimating the burden of genital warts in Taiwan.
    Sex Health 2017 Oct 3. Epub 2017 Oct 3.
    Background: This study aimed to estimate the prevalence of genital warts in Taiwan among those seeking healthcare, as well as genital-warts-related healthcare resource use and costs, and self-reported genital-warts-related psychosocial impact. Methods: Genital warts prevalence estimates were extracted from a daily record of patients examined from 31 October 2011 to 4 May 2012 by 67 physicians in Taiwan. Physicians recorded the total number of patients and genital warts patients seen daily for 2 weeks. Read More

    9-Valent human papillomavirus vaccine: a review of the clinical development program.
    Expert Rev Vaccines 2017 Nov 9;16(11):1119-1139. Epub 2017 Oct 9.
    a Merck & Co., Inc ., Kenilworth , NJ , USA.
    Introduction: The 9-valent human papillomavirus (9vHPV) vaccine covers the same HPV types (6/11/16/18) as the quadrivalent HPV (qHPV) vaccine and 5 additional cancer-causing types (31/33/45/52/58). Epidemiological studies indicate that the 9vHPV vaccine could prevent approximately 90% of cervical cancers, 70-85% of high-grade cervical dysplasia (precancers), 85-95% of HPV-related vulvar, vaginal, and anal cancers, and 90% of genital warts. Areas covered: Study design features and key findings from the 9vHPV vaccine clinical development program are reviewed. Read More

    Skin diseases of the male external genitalia in the Tanlangai Hospital in Brazzaville, Congo.
    Med Sante Trop 2017 Aug;27(3):296-300
    CHU Brazzaville, 13 avenue Auxence-IKonga, Brazzaville, Congo.
    To determine the frequency of diseases responsible for skin lesions of the male external genitalia. This descriptive retrospective study examined the medical records of patients older than 14 years treated for genital symptoms as outpatients at the Dermatology Department of Talangaï Hospital in Brazzaville in 2009-2011. Patients' sociodemographic, medical history, clinical, and laboratory data were collected on a standardized individual form. Read More

    Cost-effectiveness of HPV vaccination in the context of high cervical cancer incidence and low screening coverage.
    Vaccine 2017 Nov 9;35(46):6329-6335. Epub 2017 Sep 9.
    Institute of Family Medicine and Public Health, University of Tartu, Tartu, Estonia.
    Background: Estonia has high cervical cancer incidence and low screening coverage. We modelled the impact of population-based bivalent, quadrivalent or nonavalent HPV vaccination alongside cervical cancer screening.

    Methods: A Markov cohort model of the natural history of HPV infection was used to assess the cost-effectiveness of vaccinating a cohort of 12-year-old girls with bivalent, quadrivalent or nonavalent vaccine in two doses in a national, school-based vaccination programme. Read More

    Lifestyle factors and oncogenic papillomavirus infection in a high-risk male population.
    PLoS One 2017 12;12(9):e0184492. Epub 2017 Sep 12.
    Department of Urology, University Hospital of Vigo, Vigo, Spain.
    Background: High risk human papillomavirus (HR-HPV) infection in males is a health issue with implications for HPV-related lesions in their partners. The identification of risk factors for male infection may improve our understanding of HR-HPV transmission and prevention. The aim of this study was to evaluate the relationships between lifestyle, genital warts and HR-HPV infection. Read More

    Tumour virus vaccines: hepatitis B virus and human papillomavirus.
    Philos Trans R Soc Lond B Biol Sci 2017 Oct;372(1732)
    Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK
    Two of the most important human oncogenic viruses are hepatitis B virus (HBV) and human papillomavirus (HPV). HBV infection has been preventable by vaccination since 1982; vaccination of neonates and infants is highly effective, resulting already in decreased rates of new infections, chronic liver disease and hepato-cellular carcinoma. Nonetheless, HBV remains a global public health problem with high rates of vertical transmission from mother to child in some regions. Read More

    Attitudes towards Human Papilloma Virus Vaccination in the Latin American Andean Region.
    Healthcare (Basel) 2017 Sep 8;5(3). Epub 2017 Sep 8.
    Obstetrics and Gynecology Locum Tenens, Salinas, CA 93902, USA.
    This commentary explores the distribution of human papilloma virus (HPV) and HPV-related diseases, and factors affecting attitudes towards HPV, HPV-related diseases, and HPV vaccination in the Latin American Andean region. Lack of knowledge of HPV, known negative attitudes or incorrect assumptions about HPV, HPV-related diseases, and HPV vaccination provide a basis upon which to develop targeted HPV awareness and preventive health media campaigns. For maximal effect, media campaigns should use the internet, radio, and television to address health care providers, parents, and students. Read More

    Cost-effectiveness of human papillomavirus vaccination in Germany.
    Cost Eff Resour Alloc 2017 4;15:18. Epub 2017 Sep 4.
    Department of Health Economics and Health Care Management, School of Public Health, Bielefeld University, Universitätsstraße 25, 33615 Bielefeld, Germany.
    Background: The aim of this study was to assess the cost-effectiveness of human papillomavirus (HPV) vaccination in addition to the current cervical cancer screening programme in Germany using a dynamic transmission model.

    Methods: Based on a mathematical model simulating the transmission dynamics and the natural history of HPV infection and associated diseases (cervical intraepithelial neoplasia, cervical cancer, and genital warts), we estimated the epidemiological and economic consequences of HPV vaccination with both the quadrivalent and bivalent vaccines. In our base case analysis, we assessed the cost-effectiveness of vaccinating 12-year-old girls with a 3-dose schedule. Read More

    Understanding the Effects of Forced Sex on Sexually Transmitted Disease Acquisition and Sexually Transmitted Disease Care: Findings From the National Survey of Family Growth (2011-2013).
    Sex Transm Dis 2017 Oct;44(10):613-618
    From the *Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA; and †Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN.
    Background: Although there is evidence for heightened sexually transmitted disease (STD) acquisition among women who experienced sexual violence, little is known about their patterns of STD testing, STD diagnosis, and STD treatment.

    Methods: Data was drawn from cycle eight of the National Survey of Family Growth (2011-2013). Logistic regression analyses used SUDAAN to examine the link between forced sex and risky sexual behavior as well as forced sex and STD testing, diagnoses, treatment, and connection to care. Read More

    Recurrence of Human Papillomavirus External Genital Wart Infection Among High-Risk Adults in Montréal, Canada.
    Sex Transm Dis 2017 Nov;44(11):700-706
    From the *Clinique Médicale l'Actuel; †Sexually Transmitted Infections Unit, Institut National de Santé Publique du Québec, Montréal; ‡JSS Medical Research, Saint-Laurent; and §Merck Canada, Montréal, Québec, Canada.
    Objectives: The incidence of recurrent genital warts is not well characterized; this is especially true in a post-human papillomavirus (HPV) vaccination era. The objectives of this study were to assess the incidence of subsequent HPV-related external genital warts (EGW) episodes in high-risk male and female adults, as well as ascertain patient profile and disease characteristics, in a real-world Canadian sexual health clinical setting.

    Methods: Retrospective chart review study conducted at Clinique médicale l'Actuel, a sexual health clinic in Montréal, Québec, Canada. Read More

    Topical Imiquimod is an Effective and Safe Drug for Molluscum Contagiosum in Children.
    Acta Dermatovenerol Croat 2017 Jul;25(2):164-166
    Efstathia Pasmatzi, MD, Department of Dermatology School of Medicine University of Patras, 26504 Rio-Patras, Greece;
    Dear Editor, Molluscum contagiosum (MC) is a very common skin infection caused by a molluscipox virus gene of the poxvirus family. It usually occurs in young children, sexually active adults, and immunocompromised individuals. The typical clinical picture of this infection is characterized by asymptomatic flesh-colored, single or multiple papules, measuring 2-6 mm in diameter with a central umbilication that occur on the skin and the mucous membranes. Read More

    Efficacy and Tolerability of Polyphenon E in "Difficult-to-Treat" Multiple Genital Warts in an HIV-Positive Male Subject.
    Case Rep Dermatol 2017 May-Aug;9(2):55-59. Epub 2017 Jun 27.
    Medical Department, Difa Cooper, Caronno, Italy.
    A 55-year-old man, nonsmoker, with a HIV-positive history came to our attention in February 2017. He was on treatment with Stribild(TM), 1 capsule daily (150 mg elvitegravir, 150 mg cobicistat, 200 mg emtricitabine, and 245 mg tenofovir disoproxil). The CD4+/CD8+ cellular count was 326/µL (normal values: 404-1,612); the CD3+/CD8+ cellular count was 819/µL (normal values: 220-1,219). Read More

    Detection of human papillomavirus in urine among heterosexual men in relation to location of genital warts and circumcision status.
    Sex Transm Infect 2017 Sep 2. Epub 2017 Sep 2.
    Melbourne Sexual Health Centre, Alfred Health, Melbourne, Victoria, Australia.
    Objective: Human papillomavirus (HPV) surveillance is important to monitor the effectiveness of national HPV vaccination programmes. Positivity of HPV in urine in men varies with different sampling methods. We aimed to determine the positivity for detection of HPV-6/11 in urine samples among men in relation to the position of genital warts and circumcision status. Read More

    Prevalence of anogenital HPV infection, related disease and risk factors among HIV-infected men in inner-city Johannesburg, South Africa: baseline findings from a cohort study.
    BMC Public Health 2017 Jul 4;17(Suppl 3):425. Epub 2017 Jul 4.
    Wits Reproductive Health and HIV Institute (WRHI), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
    Background: Persistent high-risk human papillomavirus (HR-HPV) infection is associated with the development of anogenital cancers, particularly in men living with HIV (MLWH). We describe the prevalence of anogenital HPV infection, abnormal anal cytology and anogenital warts (AGWs) in MLWH in Johannesburg, and explore whether HPV infection and receipt of antiretroviral treatment is associated with detection of abnormal anal cytology and AGWs.

    Methods: We enrolled a cohort of 304 sexually-active MLWH ≥18 years, who completed a questionnaire and physical examination. Read More

    "My mom said it wasn't important": A case for catch-up human papillomavirus vaccination among young adult women in the United States.
    Prev Med 2017 Dec 18;105:1-4. Epub 2017 Aug 18.
    Department of Community and Family Health, College of Public Health, University of South Florida, 13201 Bruce B. Downs Blvd. MDC 56, Tampa, FL 33612, USA. Electronic address:
    The human papillomavirus (HPV) vaccine prevents HPV-related diseases, including anogenital cancers and genital warts. In the United States, while it is recommended to adolescents ages 11 to 12, catch-up vaccination is available for those previously unvaccinated until age 26. Parental decisions or lack of provider recommendation during adolescence are barriers to on-time vaccination. Read More

    Knowledge, Beliefs and Attitudes of Somali Men in Olmsted County, Minnesota, U.S., on the Human Papillomavirus Vaccine and Cervical Cancer Screening: January 17, 2015.
    J Immigr Minor Health 2017 Aug 16. Epub 2017 Aug 16.
    School of Public Health, University of Minnesota, Minneapolis, MN, USA.
    This study explores the general knowledge of Human Papillomavirus vaccine (HPV) and cervical cancer screening (CCS) among Somali men in the U.S., who are major decision-makers in Somali households. Read More

    The cytotoxic mechanism of epigallocatechin gallate on proliferative HaCaT keratinocytes.
    J Biomed Sci 2017 Aug 15;24(1):55. Epub 2017 Aug 15.
    Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, 114, Taiwan, Republic of China.
    Background: Epigallocatechin gallate (EGCG) is the major ingredient of sinecatechins ointment, approved for the treatment of external genital and perianal warts. However, the molecular mechanism for EGCG's effect on warts resulting from the human papillomavirus (HPV) infection of keratinocytes is not well understood. HPV may survive in proliferative keratinocytes and may be involved in cell cycle regulation and progression. Read More

    HPV-11 variability, persistence and progression to genital warts in men: the HIM study.
    J Gen Virol 2017 Sep 15;98(9):2339-2342. Epub 2017 Aug 15.
    1​Molecular Biology Laboratory, Center for Translational Research in Oncology, Instituto do Cancer do Estado de Sao Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
    HPV-11 and HPV-6 are the etiological agents of about 90 % of genital warts (GWs). The intra-typic variability of HPV-11 and its association with infection persistence and GW development remains undetermined. Here, HPV infection in men (HIM) participants who had an HPV-11 genital swab and/or GW, preceded or not by a normal skin genital swab were analysed. Read More

    Molecular Screening and Single Nucleotide Polymorphism Typing of Molluscum Contagiosum Virus (MCV) from Genital Specimens, between 2012 and 2015
    Iran Biomed J 2017 08 15. Epub 2017 Aug 15.
    Research and Development (R&D) Department, Keyvan Virology Specialty Laboratory (KVSL), Tehran, Iran.
    Background: The present study is the first comprehensive report of the Molluscum contagiosum virus (MCV) in Iran based on the molecular technique for differentiation and typing of the MCV1 and MCV2.

    Methods: Patients were diagnosed as having tumor-like genital warts less than 5 mm in diameter, and HIV seronegative samples were chosen for this cross-sectional study. TaqMan real-time PCR was used to identify MCV following clinical examination. Read More

    Risk of cancer in patients with genital warts: A nationwide, population-based cohort study in Taiwan.
    PLoS One 2017 14;12(8):e0183183. Epub 2017 Aug 14.
    Department of Pediatrics, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan.
    Background: Condyloma acuminata currently affects around 1% of sexually active adults, and its incidence is increasing. The coexistence of genital warts (GW) and certain cancers and an association between human papillomavirus (HPV) and various malignancies have been reported. Therefore, we conducted this large national study to analyze the risk of malignancies among men and women with GW in Taiwan. Read More

    Progress in prophylactic human papillomavirus (HPV) vaccination in 2016: A literature review.
    Vaccine 2017 Aug 8. Epub 2017 Aug 8.
    Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Zaloška 4, 1000 Ljubljana, Slovenia. Electronic address:
    Prophylactic human papillomavirus (HPV) vaccine represents a revolutionary step forward in preventing HPV-related cancers, especially cervical carcinoma. Alongside appropriate screening, it has the potential to dramatically reduce cervical cancer incidence and even eradicate it. Following extensive evaluations in clinical trials, the first decade of routine HPV vaccine use provides overwhelming evidence of the vaccines' safety and their real-life effectiveness. Read More

    The human papillomavirus replication cycle, and its links to cancer progression: a comprehensive review.
    Clin Sci (Lond) 2017 Sep 10;131(17):2201-2221. Epub 2017 Aug 10.
    MRC-University of Glasgow Centre for Virus Research; Institute of Infection, Immunity and Inflammation; College of Medical, Veterinary and Life Sciences, University of Glasgow, Garscube Estate, Glasgow G61 1QH, Scotland, U.K.
    HPVs (human papillomaviruses) infect epithelial cells and their replication cycle is intimately linked to epithelial differentiation. There are over 200 different HPV genotypes identified to date and each displays a strict tissue specificity for infection. HPV infection can result in a range of benign lesions, for example verrucas on the feet, common warts on the hands, or genital warts. Read More

    Antibody persistence and evidence of immune memory at 5years following administration of the 9-valent HPV vaccine.
    Vaccine 2017 Sep 5;35(37):5050-5057. Epub 2017 Aug 5.
    Merck & Co., Inc., Kenilworth, NJ, USA. Electronic address:
    Background: The 9-valent HPV (9vHPV) vaccine was developed to prevent infection and disease related to 9 HPV types (HPV6/11/16/18/31/33/45/52/58) which cause approximately 90% of cervical cancers, HPV-related vulvar, vaginal and anal cancers, and genital warts worldwide. In a pivotal efficacy study, the 9vHPV vaccine prevented infection and disease due to the 9 vaccine types. Duration of protection remains to be determined. Read More

    Functional characterization of CD4 and CD8 T cell responses among human papillomavirus infected patients with ano-genital warts.
    Virusdisease 2017 Jun 13;28(2):133-140. Epub 2017 Jun 13.
    Department of Transplant Immunology & Immunogenetics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029 India.
    Ano-genital warts are considered one of the commonest and highly infectious sexually transmitted infections. These warts are primarily caused by the human papillomavirus (HPV) of the family Papillomaviridae, genus alpha-papillomavirus, species 10 and types 6 and 11. However the high recurrence rate of warts is a matter of serious concern to the patients and a challenge for the treating physician. Read More

    Missed opportunities for catch-up human papillomavirus vaccination among university undergraduates: Identifying health decision-making behaviors and uptake barriers.
    Vaccine 2017 Jul 26. Epub 2017 Jul 26.
    Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Rd NE, Atlanta, GA 30322, USA; Hubert Department of Global Health, Rollins School of Public Health, Emory University, 1518 Clifton Rd NE, Atlanta, GA 30322, USA; Emory Vaccine Center, 954 Gatewood Rd, Atlanta, GA 30329, USA; Department of Pediatrics, School of Medicine, Emory University, 201 Dowman Dr, Atlanta, GA 30322, USA. Electronic address:
    Background: Suboptimal adolescent human papillomavirus (HPV) vaccine rates in the US highlight the need for catch-up vaccination. When teenagers enter college, there may be a shift in healthcare decision-making from parents and guardians to the students themselves. Little is known about factors influencing college students' healthcare decision-making processes. Read More

    The Cost-Effectiveness of Quadrivalent Human Papillomavirus Vaccination in Indonesia
    Asian Pac J Cancer Prev 2017 07 27;18(7):2011-2017. Epub 2017 Jul 27.
    Indonesian Technical Advisory Group on Immunization (ITAGI), Indonesia. Email:
    Objective: National cervical cancer prevention program has been initiated in Indonesia since April 2015 and the ministry of health has started efforts to integrate the HPV Vaccine in the national immunization program since Q4 2015. Thus, it becomes important to analyze the cost-effectiveness of HPV vaccine. The objective of this model is to examine the potential long-term epidemiologic and economic impact of quadrivalent HPV(qHPV;6/11/16/18) vaccination program in Indonesia. Read More

    Sexual inactivity and occurrence of STIs in relation to weight status in women: Two large population-based studies.
    Women Health 2017 Jul 25:1-16. Epub 2017 Jul 25.
    a Unit of Virus, Lifestyle and Genes , Danish Cancer Society Research Centre , Copenhagen , Denmark.
    The aim of this study was to examine sexual inactivity and occurrence of selected sexually transmitted infections in relation to body mass index. We used data from two large Danish population-based cross-sectional studies conducted in 1991-1995 (HPV study: 6869 women, aged 22-32 years) and in 2004-2005 (Liva study: 19,484 women, aged 18-45 years). Data were collected using a structured interview and measured weight, height, high-risk human papillomavirus DNA, Chlamydia DNA for the HPV study and a structured questionnaire for the Liva study. Read More

    Atypical morphology of anogenital warts is not a marker of atypical histology or of infection to the high-risk human papillomavirus genotypes.
    Int J Dermatol 2017 Oct 25;56(10):1017-1021. Epub 2017 Jul 25.
    Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
    Background: The clinical morphology of anogenital warts may vary from flat, filiform, papular, or verrucous to giant condyloma acuminatum. Clinically atypical-looking genital warts may alarm the clinician because of their suspected malignant potential, which may cause anxiety, often leading to aggressive interventions.

    Objective: To study if clinically atypical-looking anogenital warts are more likely to be premalignant or malignant as compared to typical warts. Read More

    The first case of lymphogranuloma venereum in a woman in East-Central Europe and its multiple co-infections.
    Folia Microbiol (Praha) 2017 Jul 24. Epub 2017 Jul 24.
    Department of Dermatovenereology, Second Faculty of Medicine, Charles University and Hospital Bulovka, Budinova 2, 180 81, Prague 8, Czech Republic.
    We are reporting the first case of lymphogranuloma venereum in women in East-Central Europe. A 22-year-old heterosexual woman attended our department of venereology. She complained about a burning sensation in the urethra and vaginal discharge. Read More

    Human Papillomavirus Infection and Vaccination in Males.
    Eur Urol Focus 2016 Oct 12;2(4):355-362. Epub 2016 Sep 12.
    Università Vita-Salute San Raffaele, Milan, Italy; Division of Experimental Oncology/Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy.
    Context: Human papillomavirus (HPV) is the commonest sexually transmitted pathogen in humans and is linked to the aetiopathogenesis for both benign and malignant disease in men.

    Objective: To evaluate and summarise the evidence for HPV infection and vaccination in men.

    Evidence Acquisition: A search of Medline, PubMed, and Scopus was performed to identify articles published in English within the last 10 yr addressing HPV epidemiology, the natural history of HPV infection and its long-term consequences, and vaccination in men. Read More

    The feminization of HPV: How science, politics, economics and gender norms shaped U.S. HPV vaccine implementation.
    Papillomavirus Res 2017 Jun 23;3:142-148. Epub 2017 Apr 23.
    Department of Anthropology, Rollins College, Winter Park, FL, USA. Electronic address:
    Human papillomavirus (HPV) can cause a number of anogenital cancers (i.e., cervical, penile, anal, vaginal, vulvar) and genital warts. Read More

    Cost-effectiveness analysis of the nine-valent HPV vaccine in Italy.
    Cost Eff Resour Alloc 2017 11;15:11. Epub 2017 Jul 11.
    Sanofi Pasteur MSD, Lyon, France.
    Background: In Italy HPV vaccination with the quadrivalent vaccine (Gardasil(®)) is offered actively and free of charge to girls aged 12 since 2007. A nine-valent vaccine (Gardasil 9(®)) received the European market authorization in 2015 to protect, with only 2 doses, against around 90% of all HPV positive cancers, over 80% of high-grade precancerous lesions and 90% of genital warts caused by HPV types 6/11.

    Methods: A dynamic transmission model simulating the natural history of HPV-infections was calibrated to the Italian setting and used to estimate costs and QALYs associated with vaccination strategies. Read More

    Two Landmark Studies Published in 1976/1977 Paved the Way for the Recognition of Human Papillomavirus as the Major Cause of the Global Cancer Burden.
    Acta Cytol 2017 11;61(4-5):316-337. Epub 2017 Jul 11.
    Department of Clinical Research, Biohit Oyj, Helsinki, Finland; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil.
    Two groundbreaking reports were published in Acta Cytologica at the transition of 1976 to 1977. One appeared in the last issue of 1976 [Meisels and Fortin: Acta Cytol 1976;20:505-509] and the other in the first issue of 1977 [Purola and Savia: Acta Cytol 1977;21:26-31]. Today, 40 years later, it is not an overstatement to conclude that these are the two most influential studies ever published in this journal. Read More

    A cross-sectional study estimating the burden of illness related to genital warts in South Korea.
    BMJ Open 2017 Jul 2;7(6):e014217. Epub 2017 Jul 2.
    Obstetrics and Gynaecology, Ewha Woman's University, School of Medicine, Seoul, South Korea.
    Objectives: Estimate the prevalence of genital warts (GW) and GW-related healthcare resource use and costs among male and female patients seeking treatment in South Korea.

    Design: To estimate GW prevalence, physicians in five major South Korean regions recorded daily logs of patients (n=71 655) seeking care between July 26 and September 27, 2011. Overall prevalence estimates (and 95% CIs) were weighted by the estimated number of physicians in each specialty and the estimated proportion of total patients visiting each specialist type. Read More

    Human papillomavirus vaccination: the population impact.
    F1000Res 2017 12;6:866. Epub 2017 Jun 12.
    Department of Microbiology and Infectious Diseases, Royal Women's Hospital, Parkville, Victoria, Australia.
    We currently have the knowledge and experience to prevent much of human papillomavirus (HPV)-related disease burden globally. In many countries where prophylactic HPV vaccination programs have been adopted as highly effective public health programs with good vaccine coverage, we are already seeing, in real-world settings, reduction of vaccine-related HPV-type infections, genital warts and cervical pre-cancers with potential reductions in vulvar, vaginal and anal pre-cancers. Moreover, we are seeing a change in cervical screening paradigms, as HPV-based screening programs now have strong evidence to support their use as more sensitive ways to detect underlying cervical abnormalities, as compared with conventional cervical cytology. Read More

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