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    Lichen planus hypertrophicus of the vulva - a rare entity.
    Int J STD AIDS 2017 Jan 1:956462417695052. Epub 2017 Jan 1.
    Department of Dermatology, St John's Medical College, Bangalore, India.
    Vulvovaginal lichen planus is a type of chronic inflammatory dermatosis of the vulva, usually seen as a part of widespread lichen planus. The common clinical types of vulval lichen planus include papulosquamous, erosive and pigmented types. Hypertrophic lichen planus of the vulva is a rare entity. Read More

    Sexual health of women aged 40 and over attending an inner city integrated sexual health clinic.
    Int J STD AIDS 2017 Mar 20;28(4):404-407. Epub 2016 Dec 20.
    Department of GUM/HIV, King's College Hospital NHS Foundation Trust, London, UK.
    Sexual health policy remains focussed on younger adults. However, rates of sexually transmitted infections (STIs) in older people continue to increase. We explored the sexual healthcare needs of women aged 40 and over attending an integrated sexual health clinic in South London. Read More

    Common Skin Conditions in Children: Skin Infections.
    FP Essent 2017 Feb;453:26-32
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Skin infections account for a significant subset of dermatologic conditions of childhood. Common cutaneous viral infections in children include warts, molluscum contagiosum, hand-foot-and-mouth disease, and herpes simplex. Although viral infections are self-limited and often only mildly symptomatic, they can cause anxiety, embarrassment, and health care use. Read More

    Perceptions of HPV and attitudes towards HPV vaccination amongst men who have sex with men: A qualitative analysis.
    Br J Health Psychol 2017 Feb 13. Epub 2017 Feb 13.
    Brighton and Sussex Medical School, UK.
    Objectives: Men who have sex with men (MSM) are at risk of genital warts and anal cancer due to human papillomavirus (HPV) infection. This study explores MSMs' perceptions of HPV and HPV vaccination prior to the introduction of this programme.

    Design: Focus groups and one-to-one interviews with self-identified MSM were conducted between November 2014 and March 2015 in Brighton, UK. Read More

    The clinical and economic benefits of school-based quadrivalent HPV vaccination in Singapore.
    Int J Gynaecol Obstet 2017 Feb 11. Epub 2017 Feb 11.
    Center for Observational and Real World Evidence, Merck, Kenilworth, NJ, USA.
    Objective: To investigate the clinical and economic impacts of school-based administration of the quadrivalent HPV vaccine.

    Methods: A retrospective health-economic analysis was conducted using data collected in Singapore between 2004 and 2005. A dynamic transmission model was adapted for universal vaccination that provided 80% coverage among students aged 11-12 years. Read More

    Sexually transmitted infection prevalence and related risk factors among heterosexual male methamphetamine users in China.
    Int J STD AIDS 2017 Jan 1:956462417693165. Epub 2017 Jan 1.
    4 Department of Dermatology, The Third hospital of Chengyang, Qingdao, China.
    Few studies have examined the association between methamphetamine (MA) abuse and sexually transmitted infection (STI) risk among heterosexual male MA users in China. A total of 288 heterosexual male MA users who met our inclusion criteria were recruited from nightclubs, KTVs, bars, bath centres and an STI clinic. STIs were screened among the participants, and the risk factors related to STIs were analysed by multivariate logistic regression in SPSS 11. Read More

    Prevalence and incidence of external genital warts in a sample of Italian general female population.
    BMC Infect Dis 2017 Feb 6;17(1):126. Epub 2017 Feb 6.
    HPV-unit, Istituto Nazionale Tumori Regina Elena, Via Elio Chianesi 53, Rome, Italy.
    Background: The Human papillomavirus is the most common sexually transmitted virus worldwide. The objective of this study was to estimate: 1) the prevalence and the incidence of external genital warts (eGW) in a sample of women attending community outpatient clinics and 2) the total number of eGW cases in the Italian female population aged 15-64 years.

    Methods: A prospective study was performed for a 12-month period between 2009 and 2010, among a sample of women attending community gynecological outpatient clinics located throughout Italy. Read More

    [Genital warts in HIV-infected individuals].
    Hautarzt 2017 Feb 3. Epub 2017 Feb 3.
    Klinik für Dermatologie, Venerologie und Allergologie, HELIOS St. Elisabeth Klinik Oberhausen, Universität Witten-Herdecke, 46045, Oberhausen, Deutschland.
    Anogenital warts (condylomata acuminata) are much more frequent in human immunodeficiency (HIV)-positive patients compared to HIV-negative individuals. Anogenital warts of HIV-infected patients differ from those of HIV-negative individuals with respect to their spread, occurrence on more unusual anatomical sites, human papillomavirus (HPV)-type spectrum, tendency to recur, and risk of malignant transformation. Between 18 and 56% of anogenital warts of HIV-positive patients harbor high-grade dysplasia. Read More

    Health economic evaluation of Human Papillomavirus vaccines in women from Venezuela by a lifetime Markov cohort model.
    BMC Public Health 2017 Feb 2;17(1):152. Epub 2017 Feb 2.
    IECS Instituto de Efectividad Clínica y Sanitaria, Dr. Emilio Ravignani 2024 (C1014CPV), 1014, Buenos Aires, Argentina.
    Background: Cervical cancer (CC) and genital warts (GW) are a significant public health issue in Venezuela. Our objective was to assess the cost-effectiveness of the two available vaccines, bivalent and quadrivalent, against Human Papillomavirus (HPV) in Venezuelan girls in order to inform decision-makers.

    Methods: A previously published Markov cohort model, informed by the best available evidence, was adapted to the Venezuelan context to evaluate the effects of vaccination on health and healthcare costs from the perspective of the healthcare payer in an 11-year-old girls cohort of 264,489. Read More

    Four sexually transmitted infections (STIs) in Belgian general practice: first results (2013-2014) of a nationwide continuing surveillance study.
    BMJ Open 2017 Jan 27;7(1):e012118. Epub 2017 Jan 27.
    Department of Health Services Research, Scientific Institute of Public Health, Brussels, Belgium.
    Objectives: To describe and explore data from the surveillance of chlamydia, syphilis, gonorrhoea and genital warts by the Belgian Network of Sentinel General Practices (SGP) over the first 2 years (2013 and 2014) and to estimate the incidence of these 4 sexually transmitted infections (STIs). A special focus is put on data quality.

    Design: Retrospective observational study. Read More

    No evidence for cross-protection of the HPV-16/18 vaccine against HPV-6/11 positivity in female STI clinic visitors.
    J Infect 2017 Jan 23. Epub 2017 Jan 23.
    Center for Infectious Disease Control, National Institute for Public Health and the Environment, P.O. Box 1, 3720 BA Bilthoven, The Netherlands. Electronic address:
    Objectives: Data from a vaccine trial and from post-vaccine surveillance in the United Kingdom have suggested that the bivalent HPV-16/18 vaccine offers cross-protection against HPV-6/11 and protection against anogenital warts (AGW). We studied the effect of the bivalent vaccine on genital HPV-6/11 positivity and AGW in the Netherlands.

    Methods: We included all vaccine-eligible women from the PASSYON study, a biennial cross-sectional study among 16- to 24-year-old sexually transmitted infection (STI) clinic attendants. Read More

    Ranpirnase eradicates human papillomavirus in cultured cells and heals anogenital warts in a Phase I study.
    Antivir Ther 2017 Jan 25. Epub 2017 Jan 25.
    Tamir Biotechnology, Inc., Clinical Development, San Diego, CA, USA.
    Background: Human papillomaviruses (HPV), the causative agent of anogenital warts, are the most prevalent sexually transmitted infectious agents, and wart treatment poses a persistent challenge. We assessed the safety and efficacy of treating HPV with ranpirnase, an endoribonuclease from the Northern Leopard frog that has been used extensively in Phase III oncology trials.

    Methods: As initial verification of ranpirnase antiviral activity, we assessed its ability to eliminate papillomaviruses in cultured cells. Read More

    Should Female Partners of Men With Non-Gonococcal Urethritis, Negative for Chlamydia trachomatis and Mycoplasma genitalium, Be Informed and Treated? Clinical Outcomes From a Partner Study of Heterosexual Men With NGU.
    Sex Transm Dis 2017 Feb;44(2):126-130
    From the *Melbourne Sexual Health Centre, Alfred Health, Carlton; and †Central Clinical School, Monash University, Clayton, Victoria, Australia.
    Background: To determine if female partners of men with pathogen-negative non-gonococcal urethritis (NGU) are at risk of genital infection.

    Methods: Secondary data analysis using health records from a large sexually transmitted disease clinic in Melbourne of 1710 men and their female partners attending on the same day from January 2006 to April 2015. Proportions of female partners with symptoms suggesting genital infection or pelvic inflammatory disease (PID) were determined for: (1) men with NGU and no Chlamydia trachomatis or Mycoplasma genitalium (referred to as pathogen-negative NGU) (n = 91); 2) men with urethral C. Read More

    Chimeric L2-Based Virus-Like Particle (VLP) Vaccines Targeting Cutaneous Human Papillomaviruses (HPV).
    PLoS One 2017 5;12(1):e0169533. Epub 2017 Jan 5.
    Laboratory of Viral Oncology, Department of Dermatology, Medical University of Vienna, Vienna, Austria.
    Common cutaneous human papillomavirus (HPV) types induce skin warts, whereas species beta HPV are implicated, together with UV-radiation, in the development of non-melanoma skin cancer (NMSC) in immunosuppressed patients. Licensed HPV vaccines contain virus-like particles (VLP) self-assembled from L1 major capsid proteins that provide type-restricted protection against mucosal HPV infections causing cervical and other ano-genital and oro-pharyngeal carcinomas and warts (condylomas), but do not target heterologous HPV. Experimental papillomavirus vaccines have been designed based on L2 minor capsid proteins that contain type-common neutralization epitopes, to broaden protection to heterologous mucosal and cutaneous HPV types. Read More

    Human papilloma virus in oral cancer.
    J Korean Assoc Oral Maxillofac Surg 2016 Dec 27;42(6):327-336. Epub 2016 Dec 27.
    Oral and Maxillofacial Microvascular Reconstruction Lab, Brong Ahafo Regional Hospital, Sunyani, Ghana.; Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.
    Cervical cancer is the second most prevalent cancer among women, and it arises from cells that originate in the cervix uteri. Among several causes of cervical malignancies, infection with some types of human papilloma virus (HPV) is well known to be the greatest cervical cancer risk factor. Over 150 subtypes of HPV have been identified; more than 40 types of HPVs are typically transmitted through sexual contact and infect the anogenital region and oral cavity. Read More

    Spotlight on the 9-valent HPV vaccine.
    Drug Des Devel Ther 2017 20;11:35-44. Epub 2016 Dec 20.
    Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
    Starting in 2006, vaccination against human papillomavirus (HPV) has been progressively implemented in most developed countries. Two vaccines have been successfully used, a bivalent vaccine targeting HPV-related cancers (bHPV) and a quadrivalent vaccine (qHPV) targeting both HPV-related cancers and genital warts. Between December 2014 and June 2015, a new nonavalent HPV vaccine (9vHPV) was granted marketing authorization in the USA and Europe. Read More

    Clinico-Epidemiological Profile of Viral Sexually Transmitted Infections in Seropositive Patients Attending a Tertiary Care Hospital in North India.
    J Int Assoc Provid AIDS Care 2017 Jan 1:2325957416686196. Epub 2017 Jan 1.
    2 Department of Dermatology, Ram Manohar Lohia Hospital, Baba Kharak Singh Marg, New Delhi, India.
    Sexually transmitted diseases are a major public health problem both in developing and in developed countries, and especially with the co-synergy with HIV infection, there is an increasing need to have a proper understanding of the clinicodemographic patterns of sexually transmitted infections (STIs) for planning and implementing control strategies. Worldwide, there is an increased preponderance of viral STIs. Increasing incidence and altered clinical presentation of viral STIs in patients with HIV pose a diagnostic challenge; thereby, we studied the demographic profile of HIV-seropositive patients and compared clinical manifestations of viral STIs in HIV-seropositive patients to those in seronegative individuals. Read More

    The low-risk papillomaviruses.
    Virus Res 2017 Mar 28;231:119-127. Epub 2016 Dec 28.
    Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge, UK. Electronic address:
    Human Papillomavirus (HPV) research has been dominated by the study of a subset of Alpha papillomaviruses that together cause almost 5% of human cancers worldwide, with the focus being on the two most prominent of these (HPV16 and 18). These viruses are referred to as 'high-risk' (hrHPV), to distinguish them from the over 200 prevalent HPV types that more commonly cause only benign epithelial lesions. The 'low-risk' (lrHPV) term used to describe this group belies their cumulative morbidity. Read More

    Young Hungarian Students' Knowledge about HPV and Their Attitude Toward HPV Vaccination.
    Vaccines (Basel) 2016 Dec 29;5(1). Epub 2016 Dec 29.
    Department of Public Health, Semmelweis University, Nagyvárad tér 4., Budapest 1089, Hungary.
    (1) Background: Hungarys's estimated cervical cancer mortality was 6.9/100,000 in 2012, above the average of the EU27 countries (3.7/100,000) in the same year. Read More

    Vaccines against human papillomavirus infections: protection against cancer, genital warts or both?
    Clin Microbiol Infect 2016 Dec;22 Suppl 5:S125-S127
    Department of Gynaecology and Obstetrics, Comprehensive Cancer Centre, Medical University of Vienna, Austria.
    Since 2006, three vaccines against infections and disease caused by human papillomavirus (HPV) became available in Europe-in 2006 a quadrivalent HPV 6/11/16/18 vaccine, in 2007 a bivalent HPV 16/18 vaccine and in 2015 a nonavalent HPV 6/11/16/18/31/33/45/52/58 vaccine. HPV 16 and 18 are the most oncogenic HPV strains, causing about 70% of cervical and other HPV-related cancers, HPV 6 and 11 cause 85% of all genital warts. The additional types of the polyvalent vaccine account for about 20% of invasive cervical cancer and >35% of pre-cancer. Read More

    Gonorrhea infection increases the risk of prostate cancer in Asian population: a nationwide population-based cohort study.
    Eur J Clin Microbiol Infect Dis 2016 Dec 24. Epub 2016 Dec 24.
    Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Sec.2, Chenggong Rd., Neihu District, Taipei City, Taiwan.
    This nationwide population-based retrospective cohort study evaluated the risk of developing prostate cancer among patients with gonorrhea. We identified cases of newly diagnosed gonorrhea in men between 2000 and 2010 from the Taiwan National Health Insurance Research Database. Each patient with gonorrhea was matched to four controls, based on age and index year. Read More

    HPV-6 molecular variants association with the development of genital warts in men: The HIM Study.
    J Infect Dis 2016 Dec 23. Epub 2016 Dec 23.
    Molecular Biology Laboratory, Center for Translational Research in Oncology, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
    Background: HPV-6 and 11 are the etiological agents of approximately 90% genital warts (GWs). The impact of HPV-6 genetic heterogeneity on persistence and progression to GWs remains undetermined.

    Methods: HPV Infection in Men (HIM) study participants who had HPV-6 genital swabs and/or GWs preceded by a viable normal genital swab were analyzed. Read More

    Surgical Management of Giant Genital Condyloma Acuminata by Using Double Keystone Flaps.
    Case Rep Urol 2016 16;2016:4347821. Epub 2016 Nov 16.
    Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia.
    Condyloma acuminata in the external genitalia (genital warts) is a sexually transmitted disease that is often caused by human papillomavirus (HPV). We report a case of giant genital condyloma acuminata in a 35-year-old male patient with HIV comorbidity treated by wide surgical excision. Excision defect was covered with split thickness skin graft (STSG) and double keystone flaps. Read More

    Current global status & impact of human papillomavirus vaccination: Implications for India.
    Indian J Med Res 2016 Aug;144(2):169-180
    Screening Group, Early Detection and Prevention Section, International Agency for Research on Cancer (IARC-WHO), Lyon, France.
    This review addresses the effectiveness and safety of human papillomavirus (HPV) vaccines, the current status of its introduction in the National Immunization Programmes (NIPs) and its relevance to India, which contributes a fifth of the global burden of cervical cancer. The vast literature on efficacy, acceptability and safety of HPV vaccination and its impact after population level introduction was reviewed and discussed. The efficacy of HPV vaccines in preventing high-grade precancerous lesions caused by vaccine-targeted HPV infections was 90 per cent or higher in HPV naοve women in randomized clinical trials. Read More

    Efficacy and tolerability of a new topical nitric-zinc preparation for "difficult-to-treat" warts.
    Dermatol Ther 2016 Dec 5. Epub 2016 Dec 5.
    Rutgers New Jersey Medical School.
    Treating plantar, periungual, and external genital warts can be challenging. A prospective study from four centers in Italy evaluated 37 immunocompetent patients with single or multiple warts and treated each lesion with a nitric-zinc topical solution composed of organic and inorganic acids meant to devitalize tissue and destroy HPV DNA in infected keratinocytes. Thirty of the 37 patients had external genital warts, two had plantar warts, two had palm and finger warts, and three had subungual warts for a total of 55 lesions treated. Read More

    Immunogenicity of the 9-Valent HPV Vaccine Using 2-Dose Regimens in Girls and Boys vs a 3-Dose Regimen in Women.
    JAMA 2016 12;316(22):2411-2421
    Merck & Co Inc, Kenilworth, New Jersey.
    Importance: Human papillomavirus (HPV) infections cause anogenital cancers and warts. The 9-valent HPV vaccine provides protection against 7 high-risk types of HPV responsible for 90% of cervical cancers and 2 other HPV types accounting for 90% of genital warts.

    Objective: To determine whether HPV type-specific antibody responses would be noninferior among girls and boys aged 9 to 14 years after receiving 2 doses of the 9-valent HPV vaccine compared with adolescent girls and young women aged 16 to 26 years receiving 3 doses. Read More

    Heat Increases the Editing Efficiency of Human Papillomavirus E2 Gene by Inducing Upregulation of APOBEC3A and 3G.
    J Invest Dermatol 2016 Nov 24. Epub 2016 Nov 24.
    Department of Dermatology, No.1 Hospital of China Medical University, Shenyang, China. Electronic address:
    Apolipoprotein B mRNA-editing catalytic polypeptide (APOBEC) 3 proteins have been identified as potent viral DNA mutators and have broad antiviral activity. In this study, we demonstrated that apolipoprotein B mRNA-editing catalytic polypeptide 3A (A3A) and A3G expression levels were significantly upregulated in human papillomavirus (HPV)-infected cell lines and tissues. Heat treatment resulted in elevated expression of A3A and A3G in a temperature-dependent manner in HPV-infected cells. Read More

    Developments in L2-based human papillomavirus (HPV) vaccines.
    Virus Res 2017 Mar 23;231:166-175. Epub 2016 Nov 23.
    Laboratory of Viral Oncology (LVO), Division of Immunology, Allergy and Infectious Diseases (DIAID), Department of Dermatology, Medical University of Vienna, Austria. Electronic address:
    Infections with sexually transmitted high-risk Human Papillomavirus (hrHPV), of which there are at least 15 genotypes, are responsible for a tremendous disease burden by causing cervical, and subsets of other ano-genital and oro-pharyngeal carcinomas, together representing 5% of all cancer cases worldwide. HPV subunit vaccines consisting of virus-like particles (VLP) self-assembled from major capsid protein L1 plus adjuvant have been licensed. Prophylactic vaccinations with the 2-valent (HPV16/18), 4-valent (HPV6/11/16/18), or 9-valent (HPV6/11/16/18/31/33/45/52/58) vaccine induce high-titer neutralizing antibodies restricted to the vaccine types that cause up to 90% of cervical carcinomas, a subset of other ano-genital and oro-pharyngeal cancers and 90% of benign ano-genital warts (condylomata). Read More

    Awareness and Knowledge About HPV and HPV Vaccine Among Romanian Women.
    J Cancer Educ 2016 Nov 9. Epub 2016 Nov 9.
    Department of Epidemiology, University of Medicine and Pharmacy "Grigore T. Popa", Iasi, Romania.
    Cervical cancer is one of the most prevalent gynecological malignancies worldwide. Romania has the highest incidence of this type of cancer in Europe. A successful prevention strategy has to consider the primary prevention measures (including health education on human papilloma virus (HPV) infection but also vaccination). Read More

    Evolving role of immunotherapy in the treatment of refractory warts.
    Indian Dermatol Online J 2016 Sep-Oct;7(5):364-370
    Department of Dermatology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
    Cutaneous and genital warts are common dermatological conditions caused by the human papilloma virus (HPV). Although it is a benign condition, it causes disfigurement, has a tendency to koebnerize, and can be transmitted to others. This makes adequate and timely treatment important. Read More

    High prevalence of genital HPV infection among long-term monogamous partners of women with cervical dysplasia or genital warts-Another reason for HPV vaccination of boys.
    Dermatol Ther 2017 Jan 9;30(1). Epub 2016 Oct 9.
    Dermatovenereology Department, Na Bulovce Hospital, 2nd Medical Faculty Charles University, Prague, Czech Republic.
    We conducted a cross-sectional study on the occurrence of a specific type of genital human papillomavirus (HPV) among long-term monogamous male partners of women with cervical dysplasia and genital warts. The purpose of the study was to improve knowledge with regards to the management of these couples. The presence of genital HPV-DNA was detected by PCR with broad spectrum primers followed by hybridization. Read More

    Papillomavirus and cancers: should we extend vaccination to boys in France?
    J Public Health (Oxf) 2016 Sep 27. Epub 2016 Sep 27.
    Service de Gynécologie-Obstétrique, Clinique Universitaire, Maternité Régionale Universitaire, Nancy, France.
    Background: In 2006, the HPV (Human papillomavirus) 6/11/16/18 quadrivalent vaccine was approved by the European Medicines Agency and obtained its marketing authorization in both girls and boys. Currently, the French guidelines recommend and refund vaccination of girls aged 11 to 14 with a catch-up program for females from 15 to 19 years old.

    Discussion: In France, HPV vaccination coverage tends to decrease. Read More

    Systematic Review and Meta-Analysis of Interventions to Improve Access and Coverage of Adolescent Immunizations.
    J Adolesc Health 2016 Oct;59(4S):S40-S48
    Centre for Global Child Heath, The Hospital for Sick Children, Toronto, Canada; Center of Excellence in Women and Child Health, The Aga Khan University, Karachi, Pakistan. Electronic address:
    Vaccination strategies are among the most successful and cost-effective public health strategies for preventing disease and death. Until recently, most of the existing immunization programs targeted infants and children younger than 5 years which have successfully resulted in reducing global infant and child mortality. Adolescent immunization has been relatively neglected, leaving a quarter of world's population underimmunized and hence vulnerable to a number of preventable diseases. Read More

    Risk Factors for Urethral Condyloma among Heterosexual Young Male Patients with Condyloma Acuminatum of Penile Skin.
    Infect Chemother 2016 Sep 1;48(3):216-218. Epub 2016 Sep 1.
    Department of Urology, Chonbuk National University and Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute and Medical Device Clinical Trial Center of Chonbuk National University, Jeonju, Korea.
    To our knowledge, this is the first study that focuses on risk factor of urethral condyloma (UC). The subjects of our study included genital warts patients who had been diagnosed as having condyloma acuminatum of penile skin (CAPS) with/without UC. Relationship with UC of number of life time female partners, co-infection with urethritis, circumcision status, number of CAPS and wart diameter were studied by use of multivariate analysis. Read More

    [CONDYDAV: A multicentre observational study of patients presenting external genital warts in France].
    Ann Dermatol Venereol 2016 Nov 19;143(11):675-681. Epub 2016 Sep 19.
    Département de dermatologie, CIDDIST Tarnier, hôpital Cochin, 89, rue d'Assas, 75006 Paris, France. Electronic address:
    Background: Since 2007 in France, human papilloma virus (HPV) vaccination has been licensed for use as a vaccine against HPV 6, 11, 16 and 18. The impact on the epidemiology of external genital warts (EGWs) in a large population remains unclear.

    Objectives: To determine epidemiologic and clinical features of patients presenting EGWs in France in the era of HPV vaccination. Read More

    Human papillomavirus vaccination in men who have sex with men ? what will be required by 2020 for the same dramatic changes seen in heterosexuals.
    Sex Health 2016 Sep 23. Epub 2016 Sep 23.
    This paper addresses the issue of whether men who have sex with men (MSM) will share the spectacular reductions in human papillomavirus (HPV) infection and its associated neoplasia that we are currently witnessing in heterosexuals. The reproductive rate for HPV infection in heterosexuals is not well established, but 70% vaccination coverage in women has resulted in a fall of more than 90% in genital warts and HPV types 16/18 in young women and 80% fall in young men indicating that the critical vaccination threshold has been exceeded for this group. Published data on the three elements of the reproductive rate for HPV infection (i. Read More

    Expressions of NDRG1, VEGF and Ki-67 in Condyloma Acuminatum.
    J Biol Regul Homeost Agents 2016 Jul-Sep;30(3):773-776
    Department of Dermatology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou City, PR China.
    The objective of this study was to explore the expressions and significance of NDRG1 (N-myc downregulated gene family 1), VEGF (vascular endothelial growth factor) and Ki-67 in lesions of Condyloma Acuminatum (CA). Immunohistochemistry was adopted to measure the expressions of NDRG1, VEGF and Ki-67 in 48 cases of CA and 18 normal skin controls. The positive rates of NDRG1, VEGF and Ki-67 were 63. Read More

    Therapeutic effects of topical 5-aminolevulinic acid photodynamic therapy.
    Pak J Med Sci 2016 Jul-Aug;32(4):961-4
    Jun-Ling Gao, Department of Dermatology, Huaihe Hospital of Henan University, Kaifeng 475000, Henan Province, China.
    Objective: To evaluate the therapeutic effects of combined 5-aminolevulinic acid (ALA) and photodynamic therapy (PDT) on genital warts and the safety.

    Methods: One hundred ten patients with genital warts who were treated in our hospital from June 2013 to October 2014 were selected. The warts and affected parts were disinfected with benzalkonium bromide solution, and the warts were covered with absorbent cotton that had already been added freshly prepared 20% ALA solution, packaged and fixed. Read More

    Physicians', Nurses', and Medical Assistants' Perceptions of the Human Papillomavirus Vaccine in a Large Integrated Health Care System.
    Perm J 2016 13;20(4). Epub 2016 Sep 13.
    Behavioral Scientist in the Department of Research and Evaluation for Kaiser Permanente Southern California in Pasadena, CA.
    Context: Vaccination against the human papillomavirus (HPV) decreases risks of cancer and genital warts and the need for gynecologic procedures, yet nationwide vaccination rates are low. Previous surveys exploring this phenomenon have not included input from nurses and medical assistants, who play integral roles in HPV vaccine delivery.

    Objective: To understand perceptions of HPV vaccine delivery among physicians, nurses, and medical assistants in a large integrated health care system in Southern California. Read More

    Oral and oropharyngeal cancer and the role of sexual behaviour: a systematic review.
    Community Dent Oral Epidemiol 2016 Sep 19. Epub 2016 Sep 19.
    Department of Epidemiology and Biostatistics, School of Population Health, University of Auckland, Auckland, New Zealand.
    Objectives: This systematic review identified and evaluated the evidence for the role of sexual behaviours in the development of oropharyngeal cancers (OPCs) and oral cavity cancers (OCCs).

    Methods: Following the PRISMA guidelines, we identified observational and interventional studies reporting associations between several different sexual behaviours and OPC or OCC. Study quality was assessed independently by two reviewers using a validated scoring system. Read More

    Nonconventional Use of Flash-Lamp Pulsed-Dye Laser in Dermatology.
    Biomed Res Int 2016 18;2016:7981640. Epub 2016 Aug 18.
    Laser in Dermatology Unit, University of Rome "Tor Vergata", Rome, Italy.
    Flash-lamp pulsed-dye laser (FPDL) is a nonablative technology, typically used in vascular malformation therapy due to its specificity for hemoglobin. FPDL treatments were performed in a large group of patients with persistent and/or recalcitrant different dermatological lesions with cutaneous microvessel involvement. In particular, 149 patients (73 males and 76 females) were treated. Read More

    Therapeutic management of cutaneous and genital warts.
    J Dtsch Dermatol Ges 2016 Sep;14(9):892-9
    Department of Dermatology and Allergology, Medical Center Hanau, Hanau, Germany.
    During their lifetime, at least 10 % of the population will be infected by human papillomaviruses (HPV), clinically characterized by the formation of cutaneous or genital warts. Although warts are ubiquitous, there are no defined treatments. Especially in the first six months, warts frequently resolve without therapeutic intervention. Read More

    HPV strain distribution in patients with genital warts in a female population sample.
    Oncol Lett 2016 Sep 22;12(3):1779-1782. Epub 2016 Jul 22.
    Department of Forensic Sciences and Toxicology, Medical School, University of Crete, Heraklion 71003, Greece.
    The incidence of human papillomavirus (HPV) in the human cancer domain is still a subject of intensive study. In this study, we examined cervical swab samples from 713 females with genital warts, and tested the samples for high- and low-risk genital HPV. HPV genotyping was assessed using a Genotyping test that detects HPV by the amplification of target DNA using polymerase chain reaction and nucleic acid hybridization. Read More

    As through a glass, darkly: the future of sexually transmissible infections among gay, bisexual and other men who have sex with men.
    Sex Health 2016 Sep 2. Epub 2016 Sep 2.
    The trajectory of sexually transmissible infection (STI) incidence among gay and other men who have sex with men (MSM) suggests that incidence will likely remain high in the near future. STIs were hyperendemic globally among MSM in the decades preceding the HIV epidemic. Significant changes among MSM as a response to the HIV epidemic, caused STI incidence to decline, reaching historical nadirs in the mid-1990s. Read More

    Sexually transmitted infections case notification rates in the Kingdom of Saudi Arabia, 2005-2012.
    J Infect Dev Ctries 2016 Aug 31;10(8):884-7. Epub 2016 Aug 31.
    College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
    Introduction: Sexually transmitted infections (STIs) are major public health concerns around the world. This study describes the epidemiology of reported STI cases from 2005 to 2012 in the Kingdom of Saudi Arabia.

    Methodology: The annual registry was the main source of data as reported by healthcare providers. Read More

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