Hematol Oncol Clin North Am 2018 10 26;32(5):787-809. Epub 2018 Jul 26.
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, 9609 Medical Center Drive, Room 6E516, MSC 9772, Bethesda, MD 20892-9772, USA; Commissioned Corps of the US Public Health Service, US Department of Health and Human Services, 330 C Street SW, Washington, DC 20416, USA. Electronic address:
Familial clustering of Waldenström macroglobulinemia (WM) has been observed for nearly 6 decades. Family studies have provided seminal observations in delineating the phenotypic spectrum of WM susceptibility and confirming the importance of immunoglobulin M (IgM) monoclonal gammopathy of undetermined significance (IgM MGUS) as a precursor condition for WM, providing the rationale for large population-based epidemiologic studies of IgM MGUS and WM, and providing both the basis and the material for ongoing genetic studies aimed at identifying WM predisposition genes. Together, these investigations may help elucidate the host factors underlying WM development. Read More