5,028 results match your criteria Vulvovaginitis


[Occult foreign body: A rare cause of recurrent vulvovaginitis].

An Pediatr (Barc) 2018 Nov 24. Epub 2018 Nov 24.

Serviço de Pediatria, Hospital de Santarém, Santarém, Portugal.

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November 2018

applicability of antifungal protein 2 (NFAP2) in treatment of vulvovaginal candidiasis.

Antimicrob Agents Chemother 2018 Nov 26. Epub 2018 Nov 26.

Institute of Plant Biology, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary

In the consequence of emerging number of vulvovaginitis caused by azole-resistant and biofilm-forming species, the fast and efficient treatment of this infection has become challenging. The problem is further exacerbated by the severe side-effects of azoles as long-term use medications in the recurrent form. There is therefore an increasing demand for novel and safely applicable effective antifungal therapeutic strategies. Read More

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November 2018
4 Reads

Biofilms and vulvovaginal candidiasis.

Colloids Surf B Biointerfaces 2018 Nov 7;174:110-125. Epub 2018 Nov 7.

Department of Ecology of Pathogen Agents, Hospital Manuel Gea González, Mexico City, Mexico.

Candida species, including C. albicans, are part of the mucosal flora of most healthy women, and inhabit the gastrointestinal and genitourinary tracts. Under favourable conditions, they can colonize the vulvovaginal mucosa, giving rise to symptomatic vulvovaginal candidiasis (VVC). Read More

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November 2018
14 Reads

Blue light-emitting diode in healthy vaginal mucosa-a new therapeutic possibility.

Lasers Med Sci 2018 Nov 7. Epub 2018 Nov 7.

Bahiana School of Medicine and Public Health, Av. Dom Joao VI, 275, Brotas, Salvador, Bahia, 40290-000, Brazil.

A healthy female genital mucosa has an ecosystem that remains in balance through interactions between endogenous and exogenous factors. The light-emitting diode (LED) is a device that emits light at different wavelengths, with varying color and effects. Blue light in humans is most commonly used for antimicrobial purposes and has been already applied to treat facial acne and gastric bacteria. Read More

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November 2018
6 Reads

Spontaneous Massive Vulvar Edema in Pregnancy: A Case Report.

Case Rep Obstet Gynecol 2018 1;2018:7651254. Epub 2018 Oct 1.

Catholic University of Graben, OBS/GYN Department, Democratic Republic of the Congo.

Spontaneous massive vulvar edema in pregnancy is unusual and a cause for concern. This condition should be taken seriously since it might be caused by some conditions such as preeclampsia, diabetes, vulvovaginitis, severe anemia, and neoplasms. We report a case of massive vulvar edema in a 15-year-old primigravida following tocolysis therapy at 33 weeks of gestation. Read More

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October 2018
5 Reads

An Update on the Roles of Non- Species in Vulvovaginitis.

J Fungi (Basel) 2018 Oct 31;4(4). Epub 2018 Oct 31.

Department of Medical Microbiology and Parasitology, University of Ibadan, Ibadan 200284, Nigeria.

species are one of the commonest causes of vaginitis in healthy women of reproductive age. Vulvovaginal candidiasis (VVC) is characterized by vulvovaginal itching, redness and discharge. , which is a common genito-urinary tract commensal, has been the prominent species and remains the most common fungal agent isolated from clinical samples of patients diagnosed with VVC. Read More

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October 2018
1 Read

Inhibition of CXCR4 by MicroRNA-1192 Reduces the Activation of Th17 Cells and Expression of Inflammation Factors in a Mouse Model of Vulvovaginal Candidiasis.

Cell Physiol Biochem 2018 24;50(3):893-910. Epub 2018 Oct 24.

Department of Obstetrics and Gynecology, Linyi People's Hospital, Linyi, China.

Background/aims: Vulvovaginal candidiasis (VVC) is a disease commonly occurring in sexually active women. The involvement of microRNAs in several kinds of infectious diseases has been highlighted in a number of researches. Therefore, we conducted the present study in order to investigate whether microRNA-1192 (miR-1192) would significantly target CXCR4 in Th17 cells as well as inflammatory factors in mouse models suffering from VVC. Read More

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November 2018
4 Reads
2.880 Impact Factor

Is multiple-site colonization with Candida spp. related to inadequate response to individualized fluconazole maintenance therapy in women with recurrent Candida vulvovaginitis?

Diagn Microbiol Infect Dis 2018 Nov 2;92(3):226-229. Epub 2018 Jun 2.

Femicare vzw, Tienen.

Objective: Although most women on fluconazole maintenance therapy for recurrent vulvovaginal candidosis experience a substantial improvement in quality of life, some do not respond to therapy. Is candidal colonization of extragenital sites related to suboptimal response to maintenance therapy?

Patients And Methods: Women included in a multicenter follow-up study (ReCiDiF) were evaluated for clinical signs and presence of yeasts in nose, mouth, anus, perineum, and urine. Candida was diagnosed by positive microscopy, confirmed by positive culture or polymerase chain reaction. Read More

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November 2018
2 Reads

Natural products for vulvovaginal candidiasis treatment: evidence from clinical trials.

Curr Top Med Chem 2018 Oct 2. Epub 2018 Oct 2.

Department of Pharmacology, Faculty of Pharmacy, Universidad Complutense de Madrid. Plaza Ramón y Cajal s/n, Ciudad Universitaria, 28040, Madrid. Spain.

Background: Candida albicans is an opportunistic yeast that causes more than 90% of all vulvovaginal infections. Because of inherently resistant to antifungals drugs such as azole derivatives, the search for anti-Candida albicans agents with new pharmacological targets is considered as the main therapeutic strategy to prevent and treat these type of infections. In this context, products of natural origin are a promising source of compounds with antifungal activity. Read More

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October 2018
1 Read

Alternative and complementary therapies for vulvovaginal candidiasis.

Folia Microbiol (Praha) 2018 Sep 30. Epub 2018 Sep 30.

Postgraduate Program in Health Sciences, Faculty of Medicine and Clinical Analysis Technical Course, Health Technical School, Federal University of Uberlandia, Uberlandia, Minas Gerais, Brazil.

When it comes to women's health, treating vaginal infections makes up a high proportion of the gynecological services. Among the forms of vaginitis, vulvovaginal candidiasis (VVC) is considered the second most common. Demand for new treatment alternatives is increasingly relevant, especially for therapies with fewer side effects, better tolerability, and lower cost, while still offering improved quality of life in terms of disease prevention. Read More

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September 2018
2 Reads

Candida africana in recurrent vulvovaginal candidiasis (RVVC) patients: frequency and phenotypic and genotypic characteristics.

J Med Microbiol 2018 Nov 4;67(11):1601-1607. Epub 2018 Oct 4.

4​Department of Medical Laboratory Sciences, Faculty of Paramedical, Bushehr University of Medical Sciences, Bushehr, Iran.

Purpose: Up to 75 % of all women develop vulvovaginal candidiasis (VVC), with symptoms such as vulvar erythema, pruritus and abnormal vaginal discharge. Despite the global distribution of Candida africana, its role in recurrent vulvovaginal candidiasis (RVVC) is still unclear and requires further investigation. Here, we report on the frequency of C. Read More

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November 2018
2 Reads

Comparative risk of genital infections associated with sodium-glucose co-transporter-2 inhibitors.

Diabetes Obes Metab 2018 Sep 12. Epub 2018 Sep 12.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

The extent to which sodium-glucose co-transporter-2 (SGLT2) inhibitors increase the risk of genital infections in routine clinical care, compared with other antidiabetic medications, is not clear, or whether the increased risk is consistent across gender or age subgroups, within individual SGLT2 agents, or if it is more pronounced at a particular time after treatment initiation. We conducted a retrospective cohort study using two US commercial claims databases (2013-2017). In the primary analysis, 1:1 propensity score-matched cohorts of female and male subjects with type 2 diabetes mellitus initiating SGLT2 versus dipeptidyl peptidase-4 inhibitors were created. Read More

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September 2018
16 Reads

First report of Vulvovaginitis due to in Iran.

Curr Med Mycol 2018 Mar;4(1):30-33

Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medial Sciences, Tehran, Iran.

Background And Purpose: is a non- species isolated from certain plants, soil, air, and arctic glaciers.

Case Report: This report describes a case of a 23-year-old Iranian female with pruritus and vaginal irritation. Conventional tests and molecular analysis of the samples of vaginal discharge were performed. Read More

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Chronic vulvovaginitis caused by Candida dubliniensis in an immunologically competent adult female.

Int J STD AIDS 2018 Aug 31:956462418792113. Epub 2018 Aug 31.

Department of Dermatology, Topiwala National Medical College & B.Y.L. Nair Hospital, Mumbai, India.

Candida, a commensal dimorphic fungus, is the most common microorganism that causes opportunistic fungal infections worldwide. It can cause diseases ranging from superficial mucosal infections to disseminated, systemic life-threatening infections. Among Candida species, Candida albicans is the most common infectious agent. Read More

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August 2018
2 Reads

The Relationship Between Vulvovaginal Candidiasis and Provoked Vulvodynia: A Systematic Review.

J Sex Med 2018 Sep 23;15(9):1310-1321. Epub 2018 Aug 23.

Department of Primary and Community Care, Unit Gender & Women's Health, Radboud University Medical Centre, Nijmegen, the Netherlands.

Background: Provoked vulvodynia (PVD) is a chronic vulvar pain condition affecting up to 8.3% of the female population. Despite many years of research, no clear cause for PVD has been identified. Read More

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September 2018
24 Reads

Vulvovaginal candidiasis in reproductive age women in Enugu Nigeria, clinical versus laboratory-assisted diagnosis.

Niger J Clin Pract 2018 Aug;21(8):1017-1022

Department of Obstetrics and Gynaecology, University of Nigeria Teaching Hospital, Enugu, Nigeria.

Background: Clinical diagnosis of acute vulvovaginal candidiasis (VVC) depends on evidence of clinical symptoms, but symptomatic treatment widely practiced in low-resource area may lead to overdiagnosis and treatment.

Objective: The objective of the study is to determine the prevalence of VVC among women attending gynecological clinic in University of Nigeria Teaching Hospital (UNTH) Enugu and the accuracy of clinical-based diagnosis versus laboratory test supported diagnosis and patients' characteristics that affect accuracy.

Materials And Methods: This study surveyed patients seen in a gynecologic clinic for VVC using a semi-structured, pretested, and interviewer-administered questionnaire. Read More

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August 2018
1 Read

Analysis of the Vaginal Microecological Status and Genital Tract Infection Characteristics of 751 Pregnant Women.

Med Sci Monit 2018 Aug 1;24:5338-5345. Epub 2018 Aug 1.

Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China (mainland).

BACKGROUND The aim of this study was to analyze the differences in vaginal microecological factors and genital tract infections among pregnant women of different ages. MATERIAL AND METHODS This study included 751 pregnant women from West China Second University Hospital, Sichuan University, China, from January 2015 to April 2017. After gram staining, the vaginal microecological factors of these cases were observed, including vaginal cleanliness, lactobacillus number, bacterial density, flora diversity, dominant bacteria, pH, clue cells, Candida species, and Trichomonas vaginalis. Read More

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August 2018
4 Reads

Postmenopausale vulvovaginale Beschwerden: Estradioltabletten, spezifische Gels oder normales Gel.

Authors:
Johann Steurer

Praxis (Bern 1994) 2018 Jul;107(15):850-851

1 Horten-Zentrum für praxisorientierte Forschung und Wissenstransfer, Universitätsspital Zürich.

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July 2018
2 Reads

Molecular characterization and virulence of an alphaherpesvirus isolated from a BoHV1 gB-seropositive and gE-seronegative Italian buffalo.

Vet Microbiol 2018 Jul 24;221:27-32. Epub 2018 May 24.

School of Biosciences and Veterinary Medicine, University of Camerino, Matelica, Italy. Electronic address:

During a serological survey, 157 out of 681 unvaccinated buffaloes resulted seropositive for bovine alphaherpesvirus 1 (BoHV1) glycoprotein B (gB) and seronegative for BoHV1 glycoprotein E (gE). These serological results were generally expected in animals vaccinated with a BoHV1 gE-deleted vaccine but not in unvaccinated animals. Seroneutralization tests on 36 selected sera detected neutralizing antibody titers more than three times higher for BuHV1 than for BoHV1. Read More

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July 2018
2 Reads

Long-Term Outcomes of Women With Recurrent Vulvovaginal Candidiasis After a Course of Maintenance Antifungal Therapy.

J Low Genit Tract Dis 2018 Oct;22(4):382-386

Drexel University College of Medicine and Department of Obstetrics and Gynecology, Philadelphia, PA.

Objectives: Data about long-term clinical outcome after a course of maintenance fluconazole in those with recurrent vulvovaginal candidiasis (RVVC) is lacking. We aimed to determine the rate of recurrence at a minimum of 6 months after completion of maintenance therapy.

Methods: A retrospective analysis of women with Candida albicans RVVC from January 2008 to January 2017 was performed using chart review to obtain information about recurrence after maintenance therapy. Read More

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October 2018
7 Reads

Prepubertal vulvovaginitis.

CMAJ 2018 Jul;190(26):E800

Department of Obstetrics and Gynecology (Brander), McMaster University, Hamilton, Ont.; Obstetrics and Gynecology (McQuillan), University of Calgary, Calgary, Alta.

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July 2018
3 Reads

Current treatment options for vulvovaginal candidiasis caused by azole-resistant Candida species.

Authors:
J D Sobel R Sobel

Expert Opin Pharmacother 2018 Jun 22;19(9):971-977. Epub 2018 Jun 22.

b Department of Obstetrics & Gynecology , Jefferson Medical College , Philadelphia , PA , USA.

Introduction: Clinicians are increasingly challenged by patients with refractory vulvovaginal candidiasis (VVC) caused by azole-resistant Candida species. Fluconazole resistant C.albicans is a growing and perplexing problem following years of indiscriminate drug prescription and unnecessary drug exposure and for which there are few therapeutic alternatives. Read More

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June 2018
5 Reads

Prevalence and antifungal susceptibility of Candida species among pregnant women attending a school maternity at Natal, Brazil.

Lett Appl Microbiol 2018 Sep 12;67(3):285-291. Epub 2018 Jul 12.

Departamento de Microbiologia e Parasitologia, Centro de Biociências, Universidade Federal do Rio Grande do Norte, UFRN, Natal, Rio Grande do Norte, Brazil.

Vulvovaginal candidiasis (VVC) is an inflammatory disease of the vulva and vagina caused by different yeasts of the genus Candida which is responsible for infection in pregnant patients who attended Maternidade Escola Januário Cicco, Rio Grande do Norte, Brazil. From 41 samples, 19 yeasts were identified phenotypically as Candida albicans and one as Candida glabrata which is reported as the non-albicans species most frequently isolated from vulvovaginitis. The susceptibility to selected antifungal agents (flucytosine, fluconazole, voriconazole, amphotericin B, caspofungin and micafungin) was determined, and the association between patient-related signs and symptoms aided the construction of an epidemiological profile. Read More

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September 2018
2 Reads

Efficacy, acceptability and tolerability of Zelesse® for the treatment of non-specific vulvovaginitis in paediatric patients: The NINESSE Study.

J Int Med Res 2018 Sep 7;46(9):3583-3595. Epub 2018 Jun 7.

6 Medical Department, ITF Research Pharma S.L.U., Madrid, Spain.

Objective To evaluate the efficacy, tolerability and acceptability of Zelesse®, an intimate hygiene wash solution, in the relief of the symptoms and signs of non-specific vulvovaginitis in paediatric patients. Methods The NINESSE Study was a prospective, observational, multicentre study involving females aged 2-8 years who attended paediatric offices with symptoms suggestive of non-specific vulvovaginitis. They were administered Zelesse® as a single treatment for 15 ± 5 days. Read More

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September 2018
1 Read

Thymol, eugenol and lactobacilli in a medical device for the treatment of bacterial vaginosis and vulvovaginal candidiasis.

New Microbiol 2018 07 6;41(3):220-224. Epub 2018 Jun 6.

Lower Genital Tract Disease Unit, V. Buzzi Hospital, University of Milan, Italy.

The aim of this non-interventional, observational, multicentre, open-label study was to assess the effectiveness of a vaginal gel containing extracts of Thymus vulgaris and Eugenia caryophyllus in conjunction with two specific lactobacilli strains (Lactobacillus fermentum LF10 and Lactobacillus plantarum LP02) specifically formulated in slow-release vaginal capsules, in treating bacterial vaginosis (BV), vulvovaginal candidiasis (VVC) or recurrent vulvovaginal candidiasis disease (RVVC) [Estromineral Probiogel (EPB) in Italy, or Saugella Probiogel; Meda Pharma - Mylan Group]. There was a statistically significant improvement in pruritus, burning, vulvovaginal oedema and erythema, dyspareunia and vaginal secretions in all diagnostic groups. At the end of the study, the microbiological evaluation was normal in 80. Read More

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July 2018
9 Reads

Antifungals susceptibility pattern of isolated from female genital tract at the Yaoundé Bethesda Hospital in Cameroon.

Pan Afr Med J 2017 6;28:294. Epub 2017 Dec 6.

Biotechnology Center, University of Yaoundé I, Cameroon.

Introduction: Vaginal candidiasis is considered as an important public health problem worldwide and its incidence has increased nowadays. In recent years, inappropriate and disproportionate use of antifungal drugs, automedication as well as non compliance have caused drug resistance.

Methods: This study aimed at determining the antifungal susceptibility patterns of isolated from female genital tract at in Cameroon. Read More

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June 2018
12 Reads

Mannose-Binding Lectin Gene Polymorphism and Its Association with Susceptibility to Recurrent Vulvovaginal Candidiasis.

Biomed Res Int 2018 4;2018:7648152. Epub 2018 Apr 4.

Department of Medical Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Recurrent vulvovaginal candidiasis (RVVC) is a common illness influencing childbearing women worldwide. Most women suffering from RVVC develop infection without specified risk factors. Mannose-binding lectin (MBL) is an important component of innate immune defense against infection. Read More

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October 2018
1 Read

National surveillance plan for infectious bovine rhinotracheitis (IBR) in autochthonous Italian cattle breeds: Results of first year of activity.

Vet Microbiol 2018 Jun 11;219:150-153. Epub 2018 Apr 11.

Centro di Referenza nazionale per la Rinotracheite Infettiva del Bovino (IBR), Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche, via G. Salvemini 1, 06126 Perugia, Italy. Electronic address:

Infectious bovine rhinotracheitis (IBR)/infectious pustular vulvovaginitis (IPV) caused by Bovine alphaherpesvirus 1 (BoHV-1) is a significant disease in domestic and wild cattle. In June 2015, the Ministry of Agriculture, Food and Forestry in Italy approved a national surveillance plan to control and eradicate IBR in beef cattle breeds. The objective of this study was to evaluate the results of the first year of the IBR voluntary surveillance plan in Italy. Read More

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June 2018
2 Reads

Pulsatilla decoction inhibits Candida albicans proliferation and adhesion in a mouse model of vulvovaginal candidiasis via the Dectin-1 signaling pathway.

J Ethnopharmacol 2018 Sep 26;223:51-62. Epub 2018 May 26.

First School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China. Electronic address:

Ethnopharmacological Relevance: Pulsatilla decoction (PD) is a classical prescription in Traditional Chinese Medicine (TCM) and has been reported to have inhibitory effects on Candida albicans proliferation.

Study Aim: To investigate the therapeutic effects of PD in the treatment of Vulvovaginal candidiasis (VVC) and elucidate the potential mechanism.

Materials And Methods: Female BALB/c mice (N = 90) were randomized to six treatment groups, including the Control group, Model group, three PD groups and Fluconazole group which served as a positive control (20 mg/kg weekly). Read More

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September 2018
1 Read

Psoriasin, a novel anti-Candida albicans adhesin.

J Mol Med (Berl) 2018 May 7. Epub 2018 May 7.

Department of Clinical Sciences, Division of Obstetrics and Gynecology, Danderyd Hospital and Karolinska Institutet, Stockholm, Sweden.

Candida albicans belongs to the normal microbial flora on epithelial surfaces of humans. However, under certain, still not fully understood conditions, it can become pathogenic and cause a spectrum of diseases, from local infections to life-threatening septicemia. We investigated a panel of antimicrobial proteins and peptides (AMPs), potentially involved in mucosal immunity against this pathogen. Read More

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May 2018
2 Reads

Identification of species isolated from vulvovaginitis using matrix assisted laser desorption ionization-time of flight mass spectrometry.

Curr Med Mycol 2017 Dec;3(4):21-25

Department of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Background And Purpose: Vulvovaginal candidiasis (VVC) is a common problem in women. The purpose of this study was to identify isolates by matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) from women with vulvovaginitis that were referred to Ghaem Hospital, Mashhad, Iran.

Materials And Methods: This study was conducted on 65 clinical samples isolated from women that were referred to Ghaem Hospital. Read More

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December 2017
5 Reads

Evaluation of esterase and hemolysin activities of different species isolated from vulvovaginitis cases in Lorestan Province, Iran.

Curr Med Mycol 2017 Dec;3(4):1-5

Department of Hematology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background And Purpose: Annually affecting millions of women, vulvovaginal candidiasis (VVC) is commonly described by signs and symptoms of vulvovaginal inflammation in the presence of  species. Today, the detection of the virulence factors plays a major role in the understanding of pathogenesis of candidiasis and helps produce new anticandidial drugs to improve its treatment efficiency. Herein, we aimed to evaluate the esterase and hemolysin activities of the vaginal isolates of and their relationship with the presence of VVC. Read More

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December 2017
1 Read

Effect of 2-Phenylethanol as Antifungal Agent and Common Antifungals (Amphotericin B, Fluconazole, and Itraconazole) on Candida Species Isolated from Chronic and Recurrent Cases of Candidal Vulvovaginitis.

Assay Drug Dev Technol 2018 Apr;16(3):141-149

2 Department of Medical Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences , Tehran, Iran .

The antifungal effects of 2-phenylethanol are clearly visible through its intervention in Candida morphogenesis. Chronic and recurrent vulvovaginitis, however, does not respond to this standard experimental therapy; therefore, the study presented in this article investigated the effect of common antifungal drugs (amphotericin B [AMB], fluconazole [FLU], and itraconazole [ITC]), in combination with 2-phenylethanol, on the Candida species isolated from cases of chronic and recurrent vulvovaginitis, thereby allowing the recommendation of a more appropriate treatment option. Forty isolates from patients with chronic and recurrent vaginal candidiasis were investigated in this experimental study. Read More

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April 2018
5 Reads

Distribution of genital Mollicutes in the vaginal ecosystem of women with different clinical conditions.

New Microbiol 2018 07 5;41(3):225-229. Epub 2018 Apr 5.

Microbiology, DIMES, University of Bologna, Bologna, Italy.

Ureaplasma urealyticum (UU), Ureaplasma parvum (UP), Mycoplasma hominis (MH) and Mycoplasma genitalium (MG) are the most common Mollicutes of the female genital tract. Although many studies have addressed their possible role in the vaginal ecosystem, many aspects remain to be elucidated. The aim of this study was to evaluate the vaginal presence of ureaplasmas/mycoplasmas in women with different clinical conditions. Read More

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July 2018
3 Reads

Differentiation of bovine herpesvirus1 subtypes based on UL0.5 gene sequencing.

Virusdisease 2018 Mar 25;29(1):106-108. Epub 2018 Jan 25.

2Centre for Animal Disease Research and Diagnosis, ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 India.

Infectious bovine rhinotracheitis/infectious pustular vulvovaginitis is one of the high economic importance diseases of cattle and caused by bovine herpesvirus1 (BoHV1). Based on the restriction endonuclease fingerprinting of viral DNA, the BoHV1 can be divided into three subtypes viz., BoHV1. Read More

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March 2018
4 Reads

Nerve Growth Factor and Selected Cytokines in Women With and Without Vulvodynia.

J Low Genit Tract Dis 2018 Apr;22(2):139-146

University of Michigan, Department of Family Medicine, Ann Arbor, MI.

Objective: The aim of the study was to assess the association between cytokines/neurokines after in vitro stimulation with Candida antigen or lipopolysaccharide (LPS) in blood samples among women with and without vulvodynia.

Materials And Methods: Women with vulvodynia and asymptomatic controls at three offices at the University of Michigan were examined clinically and completed a comprehensive survey in this cross-sectional study. Cytokine/neurokine levels were determined on blood samples using established ELISA protocols. Read More

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April 2018
4 Reads

Candida vaginitis: virulence, host response and vaccine prospects.

Med Mycol 2018 Apr;56(suppl_1):26-31

Departmentt. of Clinical Microbiology, G. Gennimatas General Hospital, 154 Avenue Mesogeion, 11527, Athens, Greece.

Vulvovaginal candidiasis is a common mucosal infection affecting a large proportion of women with some of them affected by recurrent often intractable forms of the disease. Thus, there is an increasing interest in understanding the pathogenesis of this disease. The aim of our work was to characterize, in animal models of vaginal candidiasis, the components of the host-fungus interaction at the mucosal level. Read More

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April 2018
5 Reads

Formulation, stability study and preclinical evaluation of a vaginal cream containing curcumin in a rat model of vulvovaginal candidiasis.

Mycoses 2018 Oct 31;61(10):723-730. Epub 2018 Jul 31.

Laboratory of Pharmacology, Federal University of São João Del-Rei, Campus Centro Oeste Dona Lindu, Divinópolis, Minas Gerais, Brazil.

Owing to the growing resistance among isolates of Candida species to usual antifungal agents and the well-known therapeutic potential of curcumin, the purpose of this study was to develop and validate a vaginal formulation containing this substance and to evaluating its effectiveness in the treatment of experimental vulvovaginal candidiasis. Curcumin was incorporated in a vaginal cream in three concentrations (0.01%, 0. Read More

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October 2018
17 Reads

Antifungal Activity of Chitosan-Coated Poly(lactic-co-glycolic) Acid Nanoparticles Containing Amphotericin B.

Mycopathologia 2018 Aug 1;183(4):659-668. Epub 2018 Mar 1.

Department of Pharmacy, Universidade Estadual do Centro-Oeste/UNICENTRO, Rua Simeão Camargo Varela de Sá 03, Guarapuava, PR, 85040-080, Brazil.

Amphotericin B (AmB) is one of the most used drugs for the treatment of systemic fungal infections; however, the treatment causes several toxic manifestations, including nephrotoxicity and hemolytic anemia. Chitosan-coated poly(lactide-co-glycolide) (PLGA) nanoparticles containing AmB were developed with the aim to decrease AmB toxicity and propose the oral route for AmB delivery. In this work, the antifungal efficacy of chitosan-coated PLGA nanoparticles containing AmB was evaluated in 20 strains of fungus isolates from patients with vulvovaginal candidiasis (01 Candida glabrata and 03 Candida albicans), bloodstream infections (04 C. Read More

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August 2018
5 Reads

Reduced Antifungal Susceptibility of Vulvovaginal Candida Species at Normal Vaginal pH Levels: Clinical Implications.

J Low Genit Tract Dis 2018 Apr;22(2):152-158

Department of Obstetrics and Gynecology, Hofstra Northwell School of Medicine, Hempstead, NY.

Objective: The aims of the study were to assess for differences in antifungal in vitro potency at pH 7 and pH 4 and to discuss any potential clinical implications of that difference.

Materials And Methods: A retrospective analysis of 217 first positive yeast cultures from 217 patients. Yeast isolates underwent antifungal susceptibility testing, with minimum inhibitory concentrations (MICs) (microgram per milliliter) measured at pH 7 and pH 4 for fluconazole, itraconazole, miconazole, clotrimazole, terconazole, and nystatin. Read More

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April 2018
3 Reads

Is non-response to fluconazole maintenance therapy for recurrent Candida vaginitis related to sensitization to atopic reactions?

Am J Reprod Immunol 2018 04 22;79(4):e12811. Epub 2018 Feb 22.

Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.

Problem: Is sensitization to atopic reaction related to treatment response of recurrent Candida vulvovaginal (RVVC)?

Method Of The Study: Analysis of ReCiDiF trial data of optimal (OR) and non-responders (NR) to fluconazole maintenance treatment, to explore medical history, physical status, family history, and vaginal immune response for potential sensitization to atopic reaction.

Results: Sociodemographic characteristics of 33 NR women were not different from 38 OR. NR had received higher number of different treatments (mean difference 1. Read More

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April 2018
5 Reads

Peptidomic Analysis of Female Reproductive Tract Secretion to Identify Putative Anti-Infection Peptides in the Female Genital System via Nanotechnologies.

J Biomed Nanotechnol 2018 Jan;14(1):215-226

The female genital system infections have high-incidence among various gynecological diseases. The role of endogenous peptides in female reproductive tract secretion has been rarely investigated regarding gynecological infections. To identify gynecological infections associated endogenous peptides, a comparative peptidomic profiling of vaginal secretion from sexually mature and perimenopause women was conducted in this study using nanoflow liquid chromatography-tandem mass spectrometer. Read More

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January 2018
26 Reads

Spontaneous resolution of labial adhesions in pre-pubertal girls.

J Paediatr Child Health 2018 Jul 13;54(7):748-753. Epub 2018 Feb 13.

Department of Gynaecology, Royal Children's Hospital, Melbourne, Victoria, Australia.

Aims: This study sought to observe the rate and timing of spontaneous resolution of labial adhesions that had been diagnosed in pre-pubertal girls. The secondary aim was to evaluate the conservative approach to management of labial adhesions that has been advocated by the Gynaecology Department, by assessing the rates of concurrent uro-gynaecological symptoms in this population, as well as parent satisfaction with their child's management.

Methods: A retrospective chart review was performed of all patients diagnosed with labial adhesions in the Department of Paediatric and Adolescent Gynaecology between 2000 and 2017. Read More

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July 2018
1 Read

Anti-Inflammatory Activity of Babassu Oil and Development of a Microemulsion System for Topical Delivery.

Evid Based Complement Alternat Med 2017 21;2017:3647801. Epub 2017 Dec 21.

Núcleo de Plataformas Tecnológicas, Instituto Aggeu Magalhães, FIOCRUZ, Av. Prof. Moraes Rego S/N, Cidade Universitária, 50740-465 Recife, PE, Brazil.

Babassu oil extraction is the main income source in nut breakers communities in northeast of Brazil. Among these communities, babassu oil is used for cooking but also medically to treat skin wounds and inflammation, and vulvovaginitis. This study aimed to evaluate the anti-inflammatory activity of babassu oil and develop a microemulsion system with babassu oil for topical delivery. Read More

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December 2017
7 Reads

Parapoxviral vulvovaginitis in Holstein cows.

J Vet Diagn Invest 2018 May 11;30(3):464-467. Epub 2018 Feb 11.

California Animal Health and Food Safety Laboratory, Tulare Laboratory (Moeller, Adaska, Blanchard), School of Veterinary Medicine, University of California, Davis, CA.

A group of Holstein first-calved heifers developed small pustules and ulcers on the vulva and in the vagina during the first 1-4 wk postpartum. The lesions varied from small red pinpoint foci to pustules and ulcers, 3-5 mm diameter. Some ulcers coalesced to form large ulcerated areas up to 15 mm diameter. Read More

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May 2018
7 Reads

High variability within Candida albicans transcription factor RLM1: Isolates from vulvovaginal infections show a clear bias toward high molecular weight alleles.

Med Mycol 2018 Jul;56(5):649-651

Centre of Molecular and Environmental Biology (CBMA), Department of Biology, University of Minho, Braga, Portugal.

Previous studies have correlated the severity of recurrent vulvovaginal Candida infections (VVC) and balanitis in patients from China with the presence of some dominant genotypes at the ORF RLM1. Here we tested VVC vs non-VVC isolates from Portugal, Brazil and Greece and, although the same genotypes were identified in VVC isolates, they were present in only five out of 150 strains. However, this analysis showed that VVC isolates presented a higher percentage of genotypes with similar high molecular weight alleles, in comparison with strains isolated from other biological sources. Read More

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July 2018
2 Reads

Bovine herpesvirus-1 in three major milk sheds of Ethiopia: Serostatus and association with reproductive disorders in dairy cattle.

Prev Vet Med 2018 Feb 1;150:126-132. Epub 2018 Jan 1.

School of Veterinary Medicine, Hawassa University, P.O. Box 05, Hawassa, Ethiopia. Electronic address:

Bovine herpesvirus-1 (BHV-1) causes infectious bovine rhinotracheitis (IBR), and infectious pustular vulvovaginitis (IPV) in cows and infectious pustular balanopostitis (IPB) in bulls worldwide. Infection of seronegative cattle with BHV-1 leads to abortion, retention of fetal membranes, increased service per conception, metritis and oophoritis. As part of an ongoing study on infectious causes of reproductive disorders in Ethiopia, this investigation aims at assessing the role of BHV-1 in the disorders and the risk factors affecting its seroprevalence. Read More

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February 2018
9 Reads

Molecular identification and antifungal susceptibility profile of species isolated from patients with vulvovaginitis in Tehran, Iran.

J Res Med Sci 2017 26;22:132. Epub 2017 Dec 26.

Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.

Background: Rapid and accurate identification and evaluation of antifungal susceptibility pattern of isolates are crucial to determine suitable antifungal drugs for the treatment of patients with vulvovaginitis candidiasis.

Materials And Methods: Vaginal samples were collected from 150 women with suspicious vaginal candidiasis, and then cultured on Sabouraoud's Dextrose Agar with chloramphenicol to isolate species. After identification of isolates using polymerase chain reaction-restriction fragment length polymorphism technique, antifungal susceptibility testing of four azolic antifungal drugs was carried out using broth microdilution method according to the CLSI M27-A3. Read More

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December 2017
2 Reads

Saccharomyces cerevisiae-based probiotic as novel anti-fungal and anti-inflammatory agent for therapy of vaginal candidiasis.

Benef Microbes 2018 Feb 30;9(2):219-230. Epub 2018 Jan 30.

1 Department of Medicine, University of Perugia, Sant'Andrea delle Fratte, 06132 Perugia, Italy.

Previously we demonstrated that the treatment with live Saccharomyces cerevisiae exerts beneficial therapeutic effects against vaginal candidiasis. Here, we address potential mechanisms particularly examining the probiotic capacity to modulate both fungus and host-related factors. We show that the S. Read More

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February 2018