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Lasers Med Sci 2019 Apr 3. Epub 2019 Apr 3.

Bahiana School of Medicine and Public Health, Av. Dom Joao VI, 275, Brotas, Salvador, Bahia, 40290-000, Brazil.

Vulvovaginal candidiasis (VVC) is a frequent infection of the female genitourinary tract. It is considered the second most common genital infection in women, after bacterial vaginosis. VVC is treated with oral or topical azole derivatives. Read More

Emerg Med Clin North Am 2019 May;37(2):193-205

Department of Emergency Medicine, University of Maryland School of Medicine, 110 South Paca Street, 6th Floor, Suite 200, Baltimore, MD 21201, USA. Electronic address:

Variations in estrogen levels across a woman's lifetime lead to important changes in genital physiology and pathophysiology. Low estrogen states like menopause and the prepubertal period share important physiologic changes, including more friable, dry, and inelastic mucosa that is prone to irritation, injury, and infection. These and other factors lead to unique gynecologic pathologic conditions encountered at the extremes of age. Read More

J Low Genit Tract Dis 2019 Apr;23(2):176-181

Unidade de Tracto Genital Inferior, Centro Hospitalar de São João, Porto, Portugal.

Objectives: Wet mount microscopy (WMM) is an ancillary test in the diagnosis of vulvovaginitis. However, there are little data about the impact of the sampling site. Our main objective was to determine the agreement between samples collected from different vaginal sites. Read More

J Biomed Nanotechnol 2019 May;15(5):1072-1089

In this study, was evaluated the chemical composition of a fraction from extract and its antimicrobial potential unloaded (Fr3) and loaded (F9Fr3) into a nanoemulsion (F9) composed of cholesterol as the oil phase (10%), polyoxyethylene 20-cetyl ether and soy phosphatidylcholine (2:1) as surfactant (20%), and a solution of phosphate buffer (pH 7.4) plus chitosan polymer dispersion (0.25%) as the aqueous phase (70%) to use for VVC treatment. Read More

Antimicrob Agents Chemother 2019 Mar 18. Epub 2019 Mar 18.

Center for Medical Mycology, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH.

Ibrexafungerp (IBX, formerly SCY-078) is a novel glucan synthase inhibitor with oral availability being evaluated for efficacy against vulvovaginal candidiasis (VVC). Bioavailability and activity are important efficacy indicators, but accepted susceptibility methods do not always accurately predict activity in an acidic environment such as the vagina. Studies were 3-fold: 1) pharmacokinetic study following oral administration in a murine model; 2) susceptibility testing of isolates from a Phase 2 VVC clinical trial by CLSI M27-A4 methodology, and 3) susceptibility testing of and isolates obtained from this trial group in RPMI-1640 adjusted to 3 different pH levels, 7. Read More

Clinicoecon Outcomes Res 2019 20;11:179-189. Epub 2019 Feb 20.

Center for Esoteric Testing, Laboratory Corporation of America Holdings, Burlington, NC, USA.

Background: Vulvovaginitis (VV) is a common reason women seek medical attention in the USA. Both the non-specific clinical presentation and risk of preterm labor or delivery necessitate accurate identification of the causative agents to guide appropriate therapy. The diagnostic accuracy of amplified molecular probe testing (AMP) has been shown to exceed that of non-amplified molecular probe (NAMP) by 20%-25%. Read More

J Pediatr 2019 Mar;206:239

Division of Pediatrics School of Medicine and Health Sciences Tecnologico de Monterrey Monterrey, Mexico.

J Low Genit Tract Dis 2019 Apr;23(2):164-169

Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA.

Objectives: We surveyed women from a primary care population to assess the prevalence of unreported vulvovaginal symptoms.

Materials And Methods: A random sample of women aged 18 to 84 years without a diagnosis of vulvovaginitis or vulvodynia in the past year were surveyed anonymously about prevalence and severity of vulvar and vaginal symptoms of itching, burning, irritation, vaginal discharge, vaginal dryness, and vulvovaginal pain in the past month. Women reporting at least 1 moderate-severe symptom were considered symptomatic. Read More

Cas Lek Cesk 2018 Dec;157(7):354-357

Disorders of vulva and vagina are the most common problem in childhood in gynecological practice. As child is not the little adult, as young girl is not little woman. Childhood is characterized by changing hormone levels, which influenced hormone-dependent tissues. Read More

Microb Pathog 2019 Mar 15;128:13-19. Epub 2018 Dec 15.

Department of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University, African Union Organization St. Abbassia, Cairo 11566, Egypt; Department of Microbiology and Immunology, School of Pharmacy & Pharmaceutical Industries, Badr University in Cairo (BUC), Entertainment Area, Badr City, Cairo, Egypt. Electronic address:

Candida albicans is considered as the leading species causing vulvovaginal candidiasis. Numerous virulence determinants and escalating resistance to antifungal therapy have contributed to its pathogenicity. However, correlation between resistance profiles and virulence patterns of C. Read More

Biomed Environ Sci 2018 Nov;31(11):816-828

Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing 210023, Jiangsu, China.

Objective: To evaluate the efficacy of cis-2-dodecenoic acid (BDSF) in the treatment and prevention of vaginal candidiasis in vivo.

Methods: The activities of different concentrations of BDSF against the virulence factors of Candida albicans (C. albicans) were determined in vitro. Read More

Int J Pharm 2019 Feb 12;556:181-191. Epub 2018 Dec 12.

Instituto de Química Rosario (IQUIR, CONICET-UNR), Suipacha 531, Rosario S2002LRK, Argentina; Área Técnica Farmacéutica, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, Rosario S2002LRK, Argentina. Electronic address:

Vaginal candidiasis is considered a frequent opportunistic mucosal infection and the second most common cause of vaginitis after bacterial vaginosis. In this work, different vaginal films based on chitosan, hydroxypropyl methylcellulose and blends of these polymers containing tioconazole, were developed and thoroughly characterized to improve the conventional therapeutics of vaginal candidiasis. Mechanical properties, swelling, adhesiveness, morphology, antifungal activity, hemocompatibility and cytotoxicity were evaluated. Read More

An Pediatr (Barc) 2018 Nov 24. Epub 2018 Nov 24.

Serviço de Pediatria, Hospital de Santarém, Santarém, Portugal.

Antimicrob Agents Chemother 2019 Feb 29;63(2). Epub 2019 Jan 29.

Institute of Plant Biology, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary

As a consequence of emerging numbers of vulvovaginitis cases caused by azole-resistant and biofilm-forming species, fast and efficient treatment of this infection has become challenging. The problem is further exacerbated by the severe side effects of azoles as long-term-use medications in the recurrent form. There is therefore an increasing demand for novel and safely applicable effective antifungal therapeutic strategies. Read More

Colloids Surf B Biointerfaces 2019 Feb 7;174:110-125. Epub 2018 Nov 7.

Department of Ecology of Pathogen Agents, Hospital Manuel Gea González, Mexico City, Mexico.

Candida species, including C. albicans, are part of the mucosal flora of most healthy women, and inhabit the gastrointestinal and genitourinary tracts. Under favourable conditions, they can colonize the vulvovaginal mucosa, giving rise to symptomatic vulvovaginal candidiasis (VVC). Read More

Indian J Med Microbiol 2018 Jul-Sep;36(3):364-368

Department of Obstetrics and Gynaecology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Background: Vulvovaginal candidiasis (VVC) is caused by overgrowth of Candida species in the female lower genital tract and most commonly caused by Candida albicans. The production of various virulence factors may attribute to their pathogenicity. Hence, this study was aimed to determine the production of various virulence factors of Candida spp. Read More

Lasers Med Sci 2018 Nov 7. Epub 2018 Nov 7.

Bahiana School of Medicine and Public Health, Av. Dom Joao VI, 275, Brotas, Salvador, Bahia, 40290-000, Brazil.

A healthy female genital mucosa has an ecosystem that remains in balance through interactions between endogenous and exogenous factors. The light-emitting diode (LED) is a device that emits light at different wavelengths, with varying color and effects. Blue light in humans is most commonly used for antimicrobial purposes and has been already applied to treat facial acne and gastric bacteria. Read More

Case Rep Obstet Gynecol 2018 1;2018:7651254. Epub 2018 Oct 1.

Catholic University of Graben, OBS/GYN Department, Democratic Republic of the Congo.

Spontaneous massive vulvar edema in pregnancy is unusual and a cause for concern. This condition should be taken seriously since it might be caused by some conditions such as preeclampsia, diabetes, vulvovaginitis, severe anemia, and neoplasms. We report a case of massive vulvar edema in a 15-year-old primigravida following tocolysis therapy at 33 weeks of gestation. Read More

J Fungi (Basel) 2018 Oct 31;4(4). Epub 2018 Oct 31.

Department of Medical Microbiology and Parasitology, University of Ibadan, Ibadan 200284, Nigeria.

species are one of the commonest causes of vaginitis in healthy women of reproductive age. Vulvovaginal candidiasis (VVC) is characterized by vulvovaginal itching, redness and discharge. , which is a common genito-urinary tract commensal, has been the prominent species and remains the most common fungal agent isolated from clinical samples of patients diagnosed with VVC. Read More

Rev Inst Med Trop Sao Paulo 2018 Oct 22;60:e59. Epub 2018 Oct 22.

Universidade Federal do Maranhão, Programa de Pós-Graduação em Saúde do Adulto, São Luís, Maranhão, Brazil.

Introduction: Candida parapsilosis is one of the main species that is able to adhere to forming biofilms on inert materials. Adhesion is the first step towards the colonization and invasion of host cells during the infectious process. Among the infections, vulvovaginal candidiasis is increasingly common. Read More

Cell Physiol Biochem 2018 24;50(3):893-910. Epub 2018 Oct 24.

Department of Obstetrics and Gynecology, Linyi People's Hospital, Linyi, China.

Background/aims: Vulvovaginal candidiasis (VVC) is a disease commonly occurring in sexually active women. The involvement of microRNAs in several kinds of infectious diseases has been highlighted in a number of researches. Therefore, we conducted the present study in order to investigate whether microRNA-1192 (miR-1192) would significantly target CXCR4 in Th17 cells as well as inflammatory factors in mouse models suffering from VVC. Read More

Diagn Microbiol Infect Dis 2018 Nov 2;92(3):226-229. Epub 2018 Jun 2.

Femicare vzw, Tienen.

Objective: Although most women on fluconazole maintenance therapy for recurrent vulvovaginal candidosis experience a substantial improvement in quality of life, some do not respond to therapy. Is candidal colonization of extragenital sites related to suboptimal response to maintenance therapy?

Patients And Methods: Women included in a multicenter follow-up study (ReCiDiF) were evaluated for clinical signs and presence of yeasts in nose, mouth, anus, perineum, and urine. Candida was diagnosed by positive microscopy, confirmed by positive culture or polymerase chain reaction. Read More

Curr Top Med Chem 2018 ;18(15):1324-1332

Department of Pharmacology, Faculty of Pharmacy, Universidad Complutense de Madrid. Plaza Ramon y Cajal s/n, Ciudad Universitaria, 28040, Madrid, Spain.

Background: Candida albicans is an opportunistic yeast that causes more than 90% of all vulvovaginal infections. Because of being inherently resistant to antifungals drugs such as azole derivatives, the search for anti-Candida albicans agents with new pharmacological targets is considered as the main therapeutic strategy to prevent and treat these types of infections. In this context, products of natural origin are a promising source of compounds with antifungal activity. Read More

Folia Microbiol (Praha) 2019 Mar 30;64(2):133-141. Epub 2018 Sep 30.

Postgraduate Program in Health Sciences, Faculty of Medicine and Clinical Analysis Technical Course, Health Technical School, Federal University of Uberlandia, Uberlandia, Minas Gerais, Brazil.

When it comes to women's health, treating vaginal infections makes up a high proportion of the gynecological services. Among the forms of vaginitis, vulvovaginal candidiasis (VVC) is considered the second most common. Demand for new treatment alternatives is increasingly relevant, especially for therapies with fewer side effects, better tolerability, and lower cost, while still offering improved quality of life in terms of disease prevention. Read More

Future Microbiol 2018 09 26;13:1375-1382. Epub 2018 Sep 26.

Department of Chemical, Biological, Pharmacological & Environmental Sciences, University of Messina, Italy.

Aim: The objective of this research was to evaluate the antifungal properties of the association between grape seed and pea by using a nonpharmacological medical device that contains them.

Materials & Methods: A murine model of vulvovaginal candidiasis, induced by Candida albicans infection, was used.

Results: We showed that topical treatment with the device significantly reduced the fungal burden in vagina and preserved vagina tissue architecture from C. Read More

J Med Microbiol 2018 Nov 4;67(11):1601-1607. Epub 2018 Oct 4.

4​Department of Medical Laboratory Sciences, Faculty of Paramedical, Bushehr University of Medical Sciences, Bushehr, Iran.

Purpose: Up to 75 % of all women develop vulvovaginal candidiasis (VVC), with symptoms such as vulvar erythema, pruritus and abnormal vaginal discharge. Despite the global distribution of Candida africana, its role in recurrent vulvovaginal candidiasis (RVVC) is still unclear and requires further investigation. Here, we report on the frequency of C. Read More

Sex Transm Infect 2019 02 18;95(1):60-66. Epub 2018 Sep 18.

Department of Global Health, University of Washington, Seattle, Washington, USA

Objectives: We evaluated the relationship of sexually transmitted infections (STIs) and genital infections during pregnancy and subsequent risk for infant mortality and stillbirth.

Methods: This was a nested longitudinal analysis using data from a study of peripartum HIV acquisition in Kenya. In the parent study, HIV-uninfected women were enrolled during pregnancy and followed until 9 months postpartum. Read More

Diabetes Obes Metab 2019 02 11;21(2):434-438. Epub 2018 Oct 11.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

The extent to which sodium-glucose co-transporter-2 (SGLT2) inhibitors increase the risk of genital infections in routine clinical care, compared with other antidiabetic medications, is not clear, or whether the increased risk is consistent across gender or age subgroups, within individual SGLT2 agents, or if it is more pronounced at a particular time after treatment initiation. We conducted a retrospective cohort study using two US commercial claims databases (2013-2017). In the primary analysis, 1:1 propensity score-matched cohorts of female and male subjects with type 2 diabetes mellitus initiating SGLT2 versus dipeptidyl peptidase-4 inhibitors were created. Read More

Curr Med Mycol 2018 Mar;4(1):30-33

Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medial Sciences, Tehran, Iran.

Background And Purpose: is a non- species isolated from certain plants, soil, air, and arctic glaciers.

Case Report: This report describes a case of a 23-year-old Iranian female with pruritus and vaginal irritation. Conventional tests and molecular analysis of the samples of vaginal discharge were performed. Read More

Int J STD AIDS 2019 Jan 31;30(1):90-93. Epub 2018 Aug 31.

Department of Dermatology, Topiwala National Medical College & B.Y.L. Nair Hospital, Mumbai, India.

Candida, a commensal dimorphic fungus, is the most common microorganism that causes opportunistic fungal infections worldwide. It can cause diseases ranging from superficial mucosal infections to disseminated, systemic life-threatening infections. Among Candida species, Candida albicans is the most common infectious agent. Read More

J Sex Med 2018 Sep 23;15(9):1310-1321. Epub 2018 Aug 23.

Department of Primary and Community Care, Unit Gender & Women's Health, Radboud University Medical Centre, Nijmegen, the Netherlands.

Background: Provoked vulvodynia (PVD) is a chronic vulvar pain condition affecting up to 8.3% of the female population. Despite many years of research, no clear cause for PVD has been identified. Read More

PLoS One 2018 22;13(8):e0202401. Epub 2018 Aug 22.

University of São Paulo, School of Pharmaceutical Sciences, São Paulo, São Paulo, Brazil.

Objective: To characterize the lipid profile in vaginal discharge of women with vulvovaginal candidiasis, cytolytic vaginosis, or no vaginal infection or dysbiosis.

Design: Cross-sectional study.

Setting: Genital Infections Ambulatory, Department of Tocogynecology, University of Campinas, Campinas, São Paulo-Brazil. Read More

J Clin Lab Anal 2019 Jan 12;33(1):e22644. Epub 2018 Aug 12.

Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.

Objective: This study was to investigate the changes of antifungal susceptibilities caused by the phenotypic switching in patients with vulvovaginal candidiasis (VVC).

Methods: 229 women were enrolled in this study. The vaginal smears of these patients were collected and gram stained for fungal microscopic observation. Read More

Niger J Clin Pract 2018 Aug;21(8):1017-1022

Department of Obstetrics and Gynaecology, University of Nigeria Teaching Hospital, Enugu, Nigeria.

Background: Clinical diagnosis of acute vulvovaginal candidiasis (VVC) depends on evidence of clinical symptoms, but symptomatic treatment widely practiced in low-resource area may lead to overdiagnosis and treatment.

Objective: The objective of the study is to determine the prevalence of VVC among women attending gynecological clinic in University of Nigeria Teaching Hospital (UNTH) Enugu and the accuracy of clinical-based diagnosis versus laboratory test supported diagnosis and patients' characteristics that affect accuracy.

Materials And Methods: This study surveyed patients seen in a gynecologic clinic for VVC using a semi-structured, pretested, and interviewer-administered questionnaire. Read More

Med Sci Monit 2018 Aug 1;24:5338-5345. Epub 2018 Aug 1.

Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China (mainland).

BACKGROUND The aim of this study was to analyze the differences in vaginal microecological factors and genital tract infections among pregnant women of different ages. MATERIAL AND METHODS This study included 751 pregnant women from West China Second University Hospital, Sichuan University, China, from January 2015 to April 2017. After gram staining, the vaginal microecological factors of these cases were observed, including vaginal cleanliness, lactobacillus number, bacterial density, flora diversity, dominant bacteria, pH, clue cells, Candida species, and Trichomonas vaginalis. Read More

PLoS One 2018 31;13(7):e0201436. Epub 2018 Jul 31.

Department of Medicine, University of Perugia, Perugia, Italy.

Vaginal candidiasis is a common disorder in women of childbearing age, caused primarily by the dimorphic fungus Candida albicans. Since C. albicans is a normal commensal of the vaginal mucosa, a long-standing question is how the fungus switches from being a harmless commensal to a virulent pathogen. Read More

Praxis (Bern 1994) 2018 Jul;107(15):850-851

1 Horten-Zentrum für praxisorientierte Forschung und Wissenstransfer, Universitätsspital Zürich.

Eur J Obstet Gynecol Reprod Biol 2018 Sep 9;228:232-237. Epub 2018 Jul 9.

Department of Biological Engineering, Inha University, Incheon 22212, Republic of Korea.

Candida albicans is the most important Candida species causing vulvovaginal candidiasis (VVC). We investigated the potential of the probiotic strains Lactobacillus fermentum MG901 and L. plantarum MG989 towards control of C. Read More

Mycoses 2018 Nov 1;61(11):857-860. Epub 2018 Aug 1.

Femicare vzw, Tienen, Belgium.

Objective: This study analyses a relation between sexual habits and the presence of Candida in extra-genital locations as well as a potential effect on therapy response.

Material And Methods: Candida cultures were obtained from mouth, nose, anus, urine and perineum of 117 women enrolled in a RVVC treatment trial (ReCiDiF). Sexual behaviour and carriage rates of extra-genital Candida of women responding well to treatment were compared to that of non-responders. Read More

Vet Microbiol 2018 Jul 24;221:27-32. Epub 2018 May 24.

School of Biosciences and Veterinary Medicine, University of Camerino, Matelica, Italy. Electronic address:

During a serological survey, 157 out of 681 unvaccinated buffaloes resulted seropositive for bovine alphaherpesvirus 1 (BoHV1) glycoprotein B (gB) and seronegative for BoHV1 glycoprotein E (gE). These serological results were generally expected in animals vaccinated with a BoHV1 gE-deleted vaccine but not in unvaccinated animals. Seroneutralization tests on 36 selected sera detected neutralizing antibody titers more than three times higher for BuHV1 than for BoHV1. Read More

Biomed Res Int 2018 7;2018:9703754. Epub 2018 Jun 7.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.

To explore risk factors of vulvovaginal candidiasis (VVC) among women of reproductive age in Xi'an district and then to offer reference for clinical prevention and treatment of VVC. Patients from the outpatient department of gynecology and obstetrics in the First Affiliated Hospital of Xi'an Jiaotong University from June 2016 to May 2017 were recruited strictly according to the inclusion and exclusion criteria. Participants diagnosed as simple VVC were assigned to the case group, while women who underwent routine gynecological examination and had normal vaginal microflora were assigned to the control group. Read More

J Low Genit Tract Dis 2018 Oct;22(4):382-386

Drexel University College of Medicine and Department of Obstetrics and Gynecology, Philadelphia, PA.

Objectives: Data about long-term clinical outcome after a course of maintenance fluconazole in those with recurrent vulvovaginal candidiasis (RVVC) is lacking. We aimed to determine the rate of recurrence at a minimum of 6 months after completion of maintenance therapy.

Methods: A retrospective analysis of women with Candida albicans RVVC from January 2008 to January 2017 was performed using chart review to obtain information about recurrence after maintenance therapy. Read More

CMAJ 2018 Jul;190(26):E800

Department of Obstetrics and Gynecology (Brander), McMaster University, Hamilton, Ont.; Obstetrics and Gynecology (McQuillan), University of Calgary, Calgary, Alta.

Expert Opin Pharmacother 2018 06 22;19(9):971-977. Epub 2018 Jun 22.

b Department of Obstetrics & Gynecology , Jefferson Medical College , Philadelphia , PA , USA.

Introduction: Clinicians are increasingly challenged by patients with refractory vulvovaginal candidiasis (VVC) caused by azole-resistant Candida species. Fluconazole resistant C.albicans is a growing and perplexing problem following years of indiscriminate drug prescription and unnecessary drug exposure and for which there are few therapeutic alternatives. Read More

Lasers Med Sci 2018 Dec 21;33(9):1925-1931. Epub 2018 Jun 21.

Biophotonics Applied to Health Sciences, Universidade Nove de Julho (UNINOVE), Brazil Rua Vergueiro 235/249, Liberdade, São Paulo, 01504-001, Brazil.

In this work, we present the efficacy of photodynamic therapy against yeast cells in an animal model. We tested two photosensitizers, methylene blue and protoporphyrin IX. Thirty-seven female BALB-c mice with a body mass of 20-25 g were used. Read More

Lett Appl Microbiol 2018 Sep 12;67(3):285-291. Epub 2018 Jul 12.

Departamento de Microbiologia e Parasitologia, Centro de Biociências, Universidade Federal do Rio Grande do Norte, UFRN, Natal, Rio Grande do Norte, Brazil.

Vulvovaginal candidiasis (VVC) is an inflammatory disease of the vulva and vagina caused by different yeasts of the genus Candida which is responsible for infection in pregnant patients who attended Maternidade Escola Januário Cicco, Rio Grande do Norte, Brazil. From 41 samples, 19 yeasts were identified phenotypically as Candida albicans and one as Candida glabrata which is reported as the non-albicans species most frequently isolated from vulvovaginitis. The susceptibility to selected antifungal agents (flucytosine, fluconazole, voriconazole, amphotericin B, caspofungin and micafungin) was determined, and the association between patient-related signs and symptoms aided the construction of an epidemiological profile. Read More

BMC Womens Health 2018 06 15;18(1):94. Epub 2018 Jun 15.

Department Clinical Laboratory, Fitche Hospital, P.O. Box 46, Oromia Administrative Region, Ethiopia.

Background: Vulvovaginal candidiasis is a global issue of concern due to its association with economic costs, sexually transmitted infections, and ascending genital tract infection. The aim of this study was to determine species distribution and antifungal susceptibility pattern of Candida species causing vulvovaginal candidiasis.

Methods: A cross sectional study was conducted from November 2015 to December 2016 at the Family Guidance Association of Ethiopia. Read More

BJOG 2018 11 11;125(12):1557. Epub 2018 Jul 11.

Department of Neonatology, National and Kapodistrian University of Athens, Medical School, Aretaieio University Hospital, Athens, Greece.

J Int Med Res 2018 Sep 7;46(9):3583-3595. Epub 2018 Jun 7.

6 Medical Department, ITF Research Pharma S.L.U., Madrid, Spain.

Objective To evaluate the efficacy, tolerability and acceptability of Zelesse®, an intimate hygiene wash solution, in the relief of the symptoms and signs of non-specific vulvovaginitis in paediatric patients. Methods The NINESSE Study was a prospective, observational, multicentre study involving females aged 2-8 years who attended paediatric offices with symptoms suggestive of non-specific vulvovaginitis. They were administered Zelesse® as a single treatment for 15 ± 5 days. Read More

New Microbiol 2018 07 6;41(3):220-224. Epub 2018 Jun 6.

Lower Genital Tract Disease Unit, V. Buzzi Hospital, University of Milan, Italy.

The aim of this non-interventional, observational, multicentre, open-label study was to assess the effectiveness of a vaginal gel containing extracts of Thymus vulgaris and Eugenia caryophyllus in conjunction with two specific lactobacilli strains (Lactobacillus fermentum LF10 and Lactobacillus plantarum LP02) specifically formulated in slow-release vaginal capsules, in treating bacterial vaginosis (BV), vulvovaginal candidiasis (VVC) or recurrent vulvovaginal candidiasis disease (RVVC) [Estromineral Probiogel (EPB) in Italy, or Saugella Probiogel; Meda Pharma - Mylan Group]. There was a statistically significant improvement in pruritus, burning, vulvovaginal oedema and erythema, dyspareunia and vaginal secretions in all diagnostic groups. At the end of the study, the microbiological evaluation was normal in 80. Read More