72,867 results match your criteria Von Hippel-Lindau Syndrome


Examination of the complexation ability of different calixarene derivatives towards [223Ra]RaCl2 in a hospital radiopharmaceutical laboratory.

Nuklearmedizin 2018 Dec 14;57(6):242-246. Epub 2018 Dec 14.

Aim: In this contribution we investigated the potential transfer of an established method for the synthesis of Ra-labelled calixarene complexes to a hospital radiopharmaceutical environment. For this purpose, commercially available [Ra]RaCl solution in pharmaceutical grade (Xofigo) was reacted with three calixarene derivatives.

Methods: A wellestablished two-phase extraction method using a two-phase solvent system was performed for complexation of the radium ions with calixarenes under slightly basic conditions. Read More

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December 2018

Kynurenic acid and zaprinast diminished CXCL17-evoked pain-related behaviour and enhanced morphine analgesia in a mouse neuropathic pain model.

Pharmacol Rep 2018 Oct 6;71(1):139-148. Epub 2018 Oct 6.

Department of Pain Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland. Electronic address:

Background: The G protein-coupled receptor 35 (GPR35), is considered important for nociceptive transmission, as suggested by accumulating evidence. This receptor was discovered in 1998; however, a lack of pharmacological tools prevented a complete understanding of its function and how to exploit it therapeutically. We studied the influence of CXCL17, kynurenic acid and zaprinast on nociceptive transmission in naïve and neuropathic mice. Read More

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October 2018

Upregulated levels and pathological aggregation of abnormally phosphorylated Tau-Protein in children with neurodevelopmental disorders.

Neurosci Biobehav Rev 2018 Dec 11. Epub 2018 Dec 11.

Department for NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Am Faßberg 11, 37077 Göttingen, Germany; German Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Str. 3a, 37075 Göttingen, Germany. Electronic address:

The tubulin-associated unit (Tau) protein is an intrinsically disordered protein that plays a well-established role in promoting microtubule assembly and stabilization in neuronal axons at all stages of development. Identification of new interacting partners and different sub-cellular localizations of Tau in recent years led to the discovery of novel physiological functions in regulation of neuronal activity, neurogenesis, long-term depression, iron export and genomic integrity. In addition, Tau gene mutations, aberrant mRNA splicing and abnormal post-translational modifications, such as hyperphosphorylation, lead to formation of pathological, insoluble Tau aggregates that are a hallmark of neurodegenerative diseases, collectively known as tauopathies. Read More

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December 2018

Distinction of sporadic and familial forms of ALS based on mitochondrial characteristics.

FASEB J 2018 Dec 14:fj201801843R. Epub 2018 Dec 14.

Laboratory of Bioenergetics and Biomembranes, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.

Bioenergetic failure, oxidative stress, and changes in mitochondrial morphology are common pathologic hallmarks of amyotrophic lateral sclerosis (ALS) in several cellular and animal models. Disturbed mitochondrial physiology has serious consequences for proper functioning of the cell, leading to the chronic mitochondrial stress. Mitochondria, being in the center of cellular metabolism, play a pivotal role in adaptation to stress conditions. Read More

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December 2018

Blood donors and their changing engagement in other prosocial behaviors.

Transfusion 2018 Dec 14. Epub 2018 Dec 14.

University of Hamburg, Research Group on Health Marketing, Hamburg, Germany.

Background: Increasing competition by nonprofit organizations provides blood donors with many options to engage themselves prosocially (e.g., by donating money or time). Read More

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December 2018

Voiding behavior and chronic pelvic pain in two types of rat nonbacterial prostatitis models: Attenuation of chronic pelvic pain by repeated administration of tadalafil.

Prostate 2018 Dec 14. Epub 2018 Dec 14.

Research Laboratories, Nippon Shinyaku Co., Ltd., Minami-ku, Kyoto, Japan.

Background: Experimental autoimmune prostatitis (EAP) and prostatitis induced by 17β-estradiol treatment combined with castration (hormone/castration-induced prostatitis; HCP) are the most commonly used rodent models of nonbacterial prostatitis. We studied the effect of the phosphodiesterase 5 inhibitor tadalafil on chronic pelvic pain in two such models in rats.

Methods: EAP was induced by intradermal injection of rat prostate antigen and complete Freund's adjuvant on Days 0 and 28. Read More

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December 2018

Regulatory B cells and advances in transplantation.

J Leukoc Biol 2018 Dec 13. Epub 2018 Dec 13.

Kidney Transplantation Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

The effects of B cell subsets with regulatory activity on the immune response to an allograft have evoked increasing interest. Here, we summarize the function and signaling of regulatory B cells (Bregs) and their potential effects on transplantation. These cells are able to suppress the immune system directly via ligand-receptor interactions and indirectly by secretion of immunosuppressive cytokines, particularly IL-10. Read More

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December 2018

SIRT3 inhibited the formation of calcium oxalate-induced kidney stones through regulating NRF2/HO-1 signaling pathway.

J Cell Biochem 2018 Dec 12. Epub 2018 Dec 12.

Department of Urology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui, China.

Oxidative stress is important for the calcium oxalate (CaOx)-induced kidney stone formation. Sirtuin 3 (SIRT3) plays an essential role in the amelioration of oxidative damages. This study aims to explore the effect of SIRT3 on the formation of CaOx-induced kidney stones and the underlying mechanism. Read More

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December 2018

Influence of canine donor plasma hemostatic protein concentration on quality of cryoprecipitate.

J Vet Intern Med 2018 Dec 11. Epub 2018 Dec 11.

Department of Clinical Sciences and Advanced Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Background: Cryoprecipitate (CRYO) is a plasma component containing high concentrations of factor VIII (FVIII), von Willebrand factor (VWF), and fibrinogen. Because Greyhounds are reported to have lower plasma VWF and fibrinogen concentrations, their plasma may not yield high potency CRYO.

Objectives: To determine if plasma hemostatic protein concentration is a good predictor of CRYO potency and if a difference exists in quality of CRYO prepared from Greyhounds versus non-Greyhounds. Read More

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December 2018

Detection of a multi-lineage mosaic NRAS mutation c.181C>A (p.Gln61Lys) in an individual with a complex congenital nevus syndrome.

Pigment Cell Melanoma Res 2018 Dec 7. Epub 2018 Dec 7.

Institute of Human Genetics, University Hospital Otto-von-Guericke-University, Magdeburg, German.

Mosaic RASopathies constitute a clinically and genetically heterogeneous group of non-inherited congenital (neuro)cutaneous disorders caused by postzygotic mutations in genes encoding components of the RAS-MAPK signaling pathway (Luo & Tsao, 2014). There are striking genotype-phenotype correlations within this group but also clinical features overlapping between distinct disorders. Congenital melanocytic nevi (CMN) are the most common lesions falling into the category of mosaic RASopathies. Read More

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December 2018

Comprehensive analysis of nuclear export of herpes simplex virus type 1 tegument proteins and their Epstein-Barr virus orthologs.

Traffic 2018 Dec 7. Epub 2018 Dec 7.

Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB, Stuttgart, Germany.

Morphogenesis of herpesviral virions is initiated in the nucleus but completed in the cytoplasm. Mature virions contain more than 25 tegument proteins many of which perform both nuclear and cytoplasmic functions suggesting they shuttle between these compartments. While nuclear import of herpesviral proteins was shown to be crucial for viral propagation, active nuclear export and its functional impact are still poorly understood. Read More

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December 2018

Anaerobic treatment of residuals from tanks transporting food and fodder.

Environ Sci Pollut Res Int 2018 Dec 13. Epub 2018 Dec 13.

Faculty of Agricultural and Environmental Sciences, University of Rostock, Justus-von-Liebig-Weg 6, 18059, Rostock, Germany.

The anaerobic digestion of wastewater from the cleaning of tank cars transporting food and fodder was investigated in both bench and pilot scales with a single-stage, mesophilic (39 °C), completely mixed process. The promising results lead to the planning and building of a 1200-m full-scale biogas plant at TS-Clean cleaning station in Fahrbinde, Germany. Due to softened water used in the cleaning of the car tanks, the alkalinity in the digester decreased as predicted by the physicochemical model developed for this treatment process. Read More

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December 2018
1 Read

Primary hypophysitis and other autoimmune disorders of the sellar and suprasellar regions.

Rev Endocr Metab Disord 2018 Dec 13. Epub 2018 Dec 13.

Medicover GmbH, Berlin/Hannover, Germany.

The pituitary gland and the hypothalamus can be affected by autoimmune-mediated structural and functional disruption. These autoimmune-mediated diseases occur more commonly in females and are often found during pregnancy or in the post-partum period. Autoimmune diseases can either affect parts of the pituitary or hypothalamus, or can involve both sellar and suprasellar structures. Read More

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December 2018
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Cardiovascular mortality attributable to dietary risk factors in 51 countries in the WHO European Region from 1990 to 2016: a systematic analysis of the Global Burden of Disease Study.

Eur J Epidemiol 2018 Dec 14. Epub 2018 Dec 14.

Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD), Halle-Jena-Leipzig, Germany.

This study was performed to highlight the relationship between single dietary risk factors and cardiovascular diseases (CVDs) in the WHO European Region. We used the comparative risk assessment framework of the Global Burden of Disease Study to estimate CVD mortality attributable to diet; comprising eleven forms of CVDs, twelve food and nutrient groups and 27 risk-outcome pairs in four GBD regions including 51 countries by age and sex between 1990 and 2016. In 2016, dietary risks were associated with 2. Read More

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December 2018
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Co-expression network analysis of gene expression profiles of HER2 breast cancer-associated brain metastasis.

Oncol Lett 2018 Dec 10;16(6):7008-7019. Epub 2018 Oct 10.

Department of Breast Surgery, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430079, P.R. China.

Brain metastasis occurs in ~30% of patients with breast cancer, and patients with human epidermal growth factor receptor 2 (HER2) breast cancer have a particularly high frequency of brain metastasis. Weighted gene co-expression network analysis was conducted to identify the hub differentially expressed genes from patients with HER2 breast cancer between brain metastases and primary tumors. The potential candidate genes were investigated in another set of patient samples to confirm their relevance. Read More

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December 2018

Associations of greenness with diabetes mellitus and glucose-homeostasis markers: The 33 Communities Chinese Health Study.

Int J Hyg Environ Health 2018 Dec 10. Epub 2018 Dec 10.

Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Guangdong Provincial Engineering Technology Research Center of Environmental and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, China. Electronic address:

Background: Residing in greener places may be protective against diabetes mellitus (DM) but evidence is scarce and comes mainly from developed countries.

Objectives: To investigate associations of residential greenness with DM prevalence and glucose-homeostasis markers in Chinese adults and whether these associations were mediated by air pollution, physical activity, and body mass index.

Methods: In 2009, a total of 15,477 adults from the cross-sectional 33 Communities Chinese Health Study provided blood samples and completed a questionnaire. Read More

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December 2018
1 Read

Excimer Laser Induced Spatially Resolved Formation and Implantation of Plasmonic Particles in Glass.

Nanomaterials (Basel) 2018 Dec 12;8(12). Epub 2018 Dec 12.

Laser-Laboratorium Göttingen e.V. Hans-Adolf-Krebs-Weg 1, D-37077 Göttingen, Germany.

Metallic nanoparticles are important building blocks for plasmonic applications. The spatially defined arrangement of these nanoparticles in a stable glass matrix is obtained here by nanosecond excimer laser irradiation at 193 nm. Two approaches are addressed: (1) Laser induced formation of particles from a dopant material pre-incorporated in the glass, (2) Particle formation and implantation by irradiation of material pre-coated on top of the glass. Read More

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December 2018

Microgravity Affects Thyroid Cancer Cells during the TEXUS-53 Mission Stronger than Hypergravity.

Int J Mol Sci 2018 Dec 12;19(12). Epub 2018 Dec 12.

Clinic for Plastic, Aesthetic and Hand Surgery, Otto von Guericke University Magdeburg, Leipziger Str. 44, D-39120 Magdeburg, Germany.

Thyroid cancer is the most abundant tumor of the endocrine organs. Poorly differentiated thyroid cancer is still difficult to treat. Human cells exposed to long-term real (r-) and simulated (s-) microgravity (µ) revealed morphological alterations and changes in the expression profile of genes involved in several biological processes. Read More

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December 2018

Determinants of Plasma Docosahexaenoic Acid Levels and Their Relationship to Neurological and Cognitive Functions in PKU Patients: A Double Blind Randomized Supplementation Study.

Nutrients 2018 Dec 7;10(12). Epub 2018 Dec 7.

Division Metabolic and Nutritional Medicine, LMU-Ludwig-Maximilians-Universität Munich, Dr. von Hauner Children's Hospital, 80337 Munich, Germany.

Children with phenylketonuria (PKU) follow a protein restricted diet with negligible amounts of docosahexaenoic acid (DHA). Low DHA intakes might explain subtle neurological deficits in PKU. We studied whether a DHA supply modified plasma DHA and neurological and intellectual functioning in PKU. Read More

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December 2018

Antioxidant Properties and the Formation of Iron Coordination Complexes of 8-Hydroxyquinoline.

Int J Mol Sci 2018 Dec 7;19(12). Epub 2018 Dec 7.

Division of Molecular Systems Biology, Department of Ecogenomics and Systems Biology, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria.

Background: The alkaloid 8-hydroxyquinoline (8HQ) is well-known for various biological activities, including antioxidant effects and especially for the formation of coordination complexes with various transition metals, such as iron, amongst others. Therefore, 8HQ was extensively explored as a promising antineurodegenerative agent. However, other authors noted pro-oxidant effects of 8HQ. Read More

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December 2018

Serial measurements of KL-6 for monitoring activity and recurrence of interstitial pneumonia with anti-aminoacyl-tRNA synthetase antibody: A retrospective cohort study.

Medicine (Baltimore) 2018 Dec;97(49):e13542

Department of Molecular and Internal Medicine.

The aim of this study was to evaluate whether serial measurements of serum Krebs von den Lungen-6 (KL-6) could be used to monitor disease activity and to detect recurrence in patients with interstitial pneumonia (IP) with anti-aminoacyl-tRNA synthetase antibodies (ARS-IP).This retrospective cohort study included 44 patients with ARS-IP. Thirty-six patients had serial data of blood tests and pulmonary function tests. Read More

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December 2018

ASSESSING THE CONTRIBUTION OF CROSS-SECTIONS TO THE UNCERTAINTY OF MONTE CARLO CALCULATIONS IN MICRO- AND NANODOSIMETRY.

Radiat Prot Dosimetry 2018 Dec 13. Epub 2018 Dec 13.

Physikalisch-Technische Bundesanstalt (PTB), Bundesallee 100, Braunschweig, Germany.

Within EURADOS Working Group 6 'Computational Dosimetry', the micro and nanodosimetry task group 6.2 has recently conducted a Monte Carlo (MC) exercise open to participants around the world. The aim of this exercise is to quantify the contribution to the uncertainty of micro and nanodosimetric simulation results arising from the use of different electron-impact cross-sections, and hence physical models, employed by different MC codes (GEANT4-DNA, PENELOPE, MCNP6, FLUKA, NASIC and PHITS). Read More

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December 2018

Different Effect of Hemodialysis on Function of Human Arterial and Venous Endothelial Cells.

Blood Purif 2018 Dec 13:1-5. Epub 2018 Dec 13.

Background/aims: Hemodialysis causes the systemic inflammatory response, which may affect the function of endothelial cells.

Methods: We studied the effect of the serum obtained after a hemodialysis session, compared to serum collected before the start of the treatment, on the gene expression and secretory activity of arterial endothelial cells (AECs) and venous endothelial cells (VECs) in in vitro culture.

Results: Serum collected at the end of the hemodialysis session increased expression of the studied genes in VECs, and at the same time decreased their expression in AECs. Read More

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December 2018

Intimate Crosstalk in Lower Airways at the Beginning of Life.

Authors:
Erika von Mutius

Cell Host Microbe 2018 Dec;24(6):758-759

Dr. von Hauner Children's Hospital, Ludwig Maximilian University, Munich, Germany; Institute for Asthma and Allergy Prevention, Helmholtz Centre, Munich, Germany; Member of the German Center for Lung Research, Munich, Germany. Electronic address:

The early life formation of the immunological and microbial environment of the human lower airways remains unknown. In this issue of Cell Host & Microbe, Pattaroni et al. (2018) shed light on this critical period, which is important for maturation or dysregulation of the microbiome and immune responses and disease development. Read More

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December 2018

Names above the rank of genus; the radical approach.

Authors:
B J Tindall

Int J Syst Evol Microbiol 2018 Dec 13. Epub 2018 Dec 13.

Leibniz Institut - DSMZ Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH, Inhoffenstraße 7B, 38124 Braunschweig, Germany.

The International Code of Nomenclature of Prokaryotes currently caters for the names of ranks from class to subspecies. The form of names and their typification is dealt with under Rules 7-22. The nature of names at different ranks has a direct influence on the structure of the Code. Read More

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December 2018

[Asthmatic attack].

MMW Fortschr Med 2018 Dec;160(21-22):50-51

Klinik für Anaesthesiologie und Intensivtherapie, Otto-von-Guericke Universität, Leipziger Straße 44, D-39120, Magdeburg, Deutschland.

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December 2018

Tree species from two contrasting habitats for use in harsh urban environments respond differently to extreme drought.

Int J Biometeorol 2018 Dec 12. Epub 2018 Dec 12.

Chair of Strategic Landscape Planning and Management, Technical University of Munich, Emil-Ramann-Straße 6, 85354, Freising, Germany.

The role of trees in city cooling has warranted much attention based on concerns over climate change and urban expansion. Simultaneously, there is an interest in introducing species from dry habitats to cope with the increasing risks of drought under climate change. The general understanding is that the evolutionary adaptation to respective resource supplies in species' habitats affects their environmental tolerance. Read More

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December 2018

Identifying the key genes and microRNAs in colorectal cancer liver metastasis by bioinformatics analysis and in vitro experiments.

Oncol Rep 2018 Nov 1. Epub 2018 Nov 1.

Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Colorectal cancer (CRC) is one of the principal causes of cancer‑associated mortality worldwide. The high incidence of liver metastasis is the leading risk factor of mortality in patients with CRC, and the mechanisms of CRC liver metastasis are poorly understood. In the present study, 7 datasets, including 3 gene expression profile datasets and 4 microRNA (miRNA) expression profile datasets were downloaded from the NCBI Gene Expression Omnibus (GEO) database to identify potential key genes and miRNAs, which may be candidate biomarkers for CRC liver metastasis. Read More

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November 2018

Advanced microRNA-based cancer diagnostics using amplified time-gated FRET.

Chem Sci 2018 Nov 11;9(42):8046-8055. Epub 2018 Sep 11.

NanoBioPhotonics , Institute for Integrative Biology of the Cell (I2BC) , Université Paris-Saclay , Université Paris-Sud , CNRS , CEA , Orsay , France . Email: ; https://www.nanofret.com.

MicroRNAs (miRNAs) play an important role in cellular functions and in the development and progression of cancer. Precise quantification of endogenous miRNAs from different clinical patient and control samples combined with a one-to-one comparison to standard technologies is a challenging but necessary endeavor that is largely neglected by many emerging fluorescence technologies. Here, we present a simple, precise, sensitive, and specific ratiometric assay for absolute quantification of miRNAs. Read More

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November 2018

Prediction of brain invasion in patients with meningiomas using preoperative magnetic resonance imaging.

Oncotarget 2018 Nov 13;9(89):35974-35982. Epub 2018 Nov 13.

Department of Neurosurgery, University Hospital Münster, Münster, North Rhine-Westphalia, Germany.

Brain invasion (BI) in meningiomas impacts WHO grading and therefore adjuvant treatment. However, BI is rare and neurosurgical sampling and neuropathological analyses are not standardised. Moreover, associations with imaging findings are sparsely known. Read More

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November 2018

Effects of permanent cardiac pacemaker implantation on vascular endothelial function, blood coagulation and cardiac function in patients with bradycardia.

Exp Ther Med 2018 Dec 28;16(6):4717-4721. Epub 2018 Sep 28.

The Heart Center, Jining First People's Hospital, Jining, Shandong 272011, P.R. China.

Changes in vascular endothelial function, blood coagulation and cardiac function indexes after the implantation of a permanent cardiac pacemaker in patients with bradycardia were investigated. A total of 53 healthy people and 117 patients with bradycardia in Jining First People's Hospital from January 2015 to August 2017 were selected. Factor VIII: coagulation (FVIII:C), von Willebr and factor (vWF), antithrombin activity (AT:A), D-dimmer (D-D), thrombomodulin (TM), tissue factor (TF), left ventricular ejection fraction (LVEF) and left ventricular end-systolic volume (LVESV) in the non-pacemaker group and the pacemaker group were significantly different from those in the control group (P<0. Read More

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December 2018

Reduced TCA cycle rates at high hydrostatic pressure hinder hydrocarbon degradation and obligate oil degraders in natural, deep-sea microbial communities.

ISME J 2018 Dec 12. Epub 2018 Dec 12.

Center for Microbial Ecology and Technology (CMET), Gent University, Coupure Links 653, Gent, B 9000, Belgium.

Petroleum hydrocarbons reach the deep-sea following natural and anthropogenic factors. The process by which they enter deep-sea microbial food webs and impact the biogeochemical cycling of carbon and other elements is unclear. Hydrostatic pressure (HP) is a distinctive parameter of the deep sea, although rarely investigated. Read More

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December 2018

Peer victimization and its impact on adolescent brain development and psychopathology.

Mol Psychiatry 2018 Dec 12. Epub 2018 Dec 12.

Medical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Chronic peer victimization has long-term impacts on mental health; however, the biological mediators of this adverse relationship are unknown. We sought to determine whether adolescent brain development is involved in mediating the effect of peer victimization on psychopathology. We included participants (n = 682) from the longitudinal IMAGEN study with both peer victimization and neuroimaging data. Read More

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December 2018

Factor VIII with 237 amino acids B-domain has extended half-life in F8-KO mice.

J Thromb Haemost 2018 Dec 7. Epub 2018 Dec 7.

Novo Nordisk Park, Måløv, Denmark.

Background: Factor VIII (FVIII) consists of the A1-A2-B-A3-C1-C2 domains. FVIII with an intermediate length B-domain of 226 amino acids (aa) has previously been evaluated in murine gene therapy studies.

Objective: To characterize FVIII with intermediate length B-domains in vitro and in vivo in F8-KO mice. Read More

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December 2018

Can All Major Ros Forming Sites of the Respiratory Chain Be Activated by High FADH /NADH Ratios?

Authors:
Peter Schönfeld

Bioessays 2018 Dec 7:e1800225. Epub 2018 Dec 7.

Institut für Biochemie und Zellbiologie, Otto-von-Guericke-Universität Magdeburg, Leipziger Str. 44, D-39120 Magdeburg, Germany.

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December 2018

Kinetic energy densities based on the fourth order gradient expansion: performance in different classes of materials and improvement via machine learning.

Phys Chem Chem Phys 2018 Dec 7. Epub 2018 Dec 7.

Department of Mechanical Engineering, National University of Singapore, Block EA #07-08, 9 Engineering Drive 1, Singapore 117576.

We study the performance of fourth-order gradient expansions of the kinetic energy density (KED) in semi-local kinetic energy functionals depending on the density-dependent variables. The formal fourth-order expansion is convergent for periodic systems and small molecules but does not improve over the second-order expansion (the Thomas-Fermi term plus one-ninth of the von Weizsäcker term). Linear fitting of the expansion coefficients somewhat improves on the formal expansion. Read More

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December 2018

Pretreatment with an angiotensin II receptor blocker abolished ameliorating actions of adipose-derived stem cell sheets on cardiac dysfunction and remodeling after myocardial infarction.

Regen Ther 2018 Dec 19;9:79-88. Epub 2018 Sep 19.

Division of Regenerative Medicine and Therapeutics, Department of Genetic Medicine and Regenerative Therapeutics, Tottori University Graduate School of Medical Science, 86 Nishi-cho, Yonago 683-8503, Japan.

Introduction: Cell sheets using myoblasts have been developed for the treatment of heart failure after myocardial infarction (MI) bridging to heart transplantation. Stem cells are supposed to be better than myoblasts as a source of cells, since they possess a potential to proliferate and differentiate into cardiomyocytes, and also have capacity to secrete angiogenic factors. Adipose-derived stem cells (ASCs) obtained from fat tissues are expected to be a new cell source for ASC sheet therapies. Read More

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December 2018

Corneal Subbasal Nerve Plexus Changes in Severe Diabetic Charcot Foot Deformity: A Pilot Study in Search for a DNOAP Biomarker.

J Diabetes Res 2018 4;2018:5910639. Epub 2018 Nov 4.

Department of Ophthalmology, Rostock University Medical Center, Doberaner Straße 140, 18057 Rostock, Germany.

Introduction: Diabetic neuroosteoarthropathy (DNOAP) early symptoms are unspecific, mimicking general infectious symptoms and rendering a diagnosis challenging. Consequently, unfavourable outcomes occur frequently, with recurrent foot ulceration, infectious complications, and eventually amputation. Corneal confocal microscopy (CCM) of the subbasal nerve plexus (SNP) is used to detect early peripheral neuropathy in diabetic patients without diabetic retinopathy. Read More

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November 2018

Structure Formation in Class I and Class II Hydrophobins at the Air-Water Interface under Multiple Compression/Expansion Cycles.

ChemistryOpen 2018 Dec 21;7(12):1005-1013. Epub 2018 Nov 21.

Institut für Chemie Martin-Luther-Universität Halle-Wittenberg Von-Danckelmann-Platz 4 06120 Halle/Saale Germany.

Hydrophobins are small amphiphilic fungal proteins empirically divided into two classes. We investigated the self-assembled structures of class I SC3 from and class II HFBII from transferred to mica from the air-water interface by using the Langmuir-Schaefer (LS) technique and atomic force microscopy (AFM). The main focus is the influence of areal constraint and multiple compressions and expansions on the morphology of the protein films. Read More

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December 2018

Upregulation of tryptophanyl-tRNA synthethase adapts human cancer cells to nutritional stress caused by tryptophan degradation.

Oncoimmunology 2018 5;7(12):e1486353. Epub 2018 Sep 5.

Brain Cancer Metabolism Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Tryptophan (Trp) metabolism is an important target in immuno-oncology as it represents a powerful immunosuppressive mechanism hijacked by tumors for protection against immune destruction. However, it remains unclear how tumor cells can proliferate while degrading the essential amino acid Trp. Trp is incorporated into proteins after it is attached to its tRNA by tryptophanyl-tRNA synthestases. Read More

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September 2018

A taxonomic revision of the Neotropical genus (Annonaceae), including five new species.

PhytoKeys 2018 26(112):1-141. Epub 2018 Nov 26.

Naturalis Biodiversity Center, section Botany, P.O. Box 9517, 2300 RA Leiden, The Netherlands Naturalis Biodiversity Center Wageningen Netherlands.

We present a taxonomic revision of , a genus of Neotropical Annonaceae occurring in lowland to premontane wet forest, mostly in areas surrounding the Andean mountain chain. We recognise 34 species, describing five as new here: from east of the Andes, Pirie & Chatrou, and Pirie & Maas, , endemic to Peru; Pirie, , from southern Peru and adjacent Bolivia and Brazil; and Pirie & Chatrou, , at higher elevations in northern Peru and Ecuador; and from west of the Andes, Pirie & Chatrou, endemic to Costa Rica, the most northerly distributed species of the genus. We provide an identification key, document diagnostic characters and distributions and provide illustrations and extensive lists of specimens, also presenting the latter in the form of mapping data with embedded links to images available online. Read More

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November 2018

One Hundred Fifty Years of Organized Health Care Services in Bosnia and Herzegovina.

Authors:
Izet Masic

Med Arch 2018 Nov;72(5):374-388

Academy of Medical Sciences of Bosnia and Herzegovina. Sarajevo, Bosnia and Herzegovina.

Introduction: Austro-Hungarian monarchy had great impact on healthcare system in Bosnia and Herzegovina (B&H), and consequences of that exist today.

Aim: To launch of the section "The Most Influential Physicians in the Development of Health Care in Bosnia and Herzegovina", in which, within next issues of the Medical Archives will be presented the prominent physicians, dentists and pharmacists who gave contribution to development of healthcare system in B&H.

Results: This paper provides a full overview from the literature about health care circumstances during 150 years in Bosnia and Herzegovina and important of the role health care institutions and of all the doctors working in B&H during the Austro-Hungarian administration. Read More

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November 2018

Mental capacity in Colombia: a comparison with the UK.

BJPsych Int 2018 Nov;15(4):85-88

Clinical Senior Lecturer in Mental Health, Ethics and Law, Wellcome Trust Senior Research Fellow, Institute of Psychiatry, Psychology and Neuroscience, King's College London.

Several international proclamations in the last decades have advocated for the dignity and autonomy of persons with mental disorders. Few discussions have been generated regarding the implication of this transition in low- and middle-income countries. The objective of this publication is to review how the concept of mental capacity has been defined in Colombian law. Read More

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November 2018

Resistive switching in sub-micrometric ZnO polycrystalline films.

Nanotechnology 2019 Feb;30(6):065707

Department of Applied Science and Technology, Politecnico di Torino, C.so Duca degli Abruzzi 24, I-10129 Torino, Italy.

Resistive switching (RS) devices are considered as the most promising alternative to conventional random access memories. They interestingly offer effective properties in terms of device scalability, low power-consumption, fast read/write operations, high endurance and state retention. Moreover, neuromorphic circuits and synapse-like devices are envisaged with RS modeled as memristors, opening the route toward beyond-Von Neumann computing architectures and intelligent systems. Read More

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February 2019

Differentiation of clear cell and non-clear cell renal cell carcinomas by all-relevant radiomics features from multiphase CT: a VHL mutation perspective.

Eur Radiol 2018 Dec 6. Epub 2018 Dec 6.

Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

Objectives: To develop a radiomics model with all-relevant imaging features from multiphasic computed tomography (CT) for differentiating clear cell renal cell carcinoma (ccRCC) from non-ccRCC and to investigate the possible radiogenomics link between the imaging features and a key ccRCC driver gene-the von Hippel-Lindau (VHL) gene mutation.

Methods: In this retrospective two-center study, two radiomics models were built using random forest from a training cohort (170 patients), where one model was built with all-relevant features and the other with minimum redundancy maximum relevance (mRMR) features. A model combining all-relevant features and clinical factors (sex, age) was also built. Read More

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December 2018

Differential Expression of PD-L1 Between Sporadic and VHL-Associated Hereditary Clear-Cell Renal Cell Carcinoma and Its Correlation With Clinicopathological Features.

Clin Genitourin Cancer 2018 Nov 13. Epub 2018 Nov 13.

Department of Urology, Peking University First Hospital, Beijing, China; Institute of Urology, Peking University, Beijing, China; National Urological Cancer Center, Beijing, China. Electronic address:

Background: Programmed death ligand-1 (PD-L1) is a potential predictive biomarker for immunotherapy in several malignancies. However, the expression level and clinical significance of PD-L1 in von Hippel-Lindau (VHL)-associated hereditary clear-cell renal cell carcinoma (ccRCC) remain unclear.

Patients And Methods: Surgical specimens were recruited from 129 patients with sporadic ccRCC and 26 patients with VHL-associated hereditary ccRCC. Read More

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November 2018

Two-component cyclase opsins of green algae are ATP-dependent and light-inhibited guanylyl cyclases.

BMC Biol 2018 Dec 6;16(1):144. Epub 2018 Dec 6.

Botanik I, Julius-Maximilians-Universität Würzburg, Biozentrum, Julius-von-Sachs-Platz 2, 97082, Würzburg, Germany.

Background: The green algae Chlamydomonas reinhardtii and Volvox carteri are important models for studying light perception and response, expressing many different photoreceptors. More than 10 opsins were reported in C. reinhardtii, yet only two-the channelrhodopsins-were functionally characterized. Read More

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December 2018

[Quality of life as a target criterion in schizophrenia therapy].

Fortschr Neurol Psychiatr 2018 Dec 12. Epub 2018 Dec 12.

Praxis Dr. Wietfeld, Fachärztin für Neurologie, Psychiatrie und Psychotherapie.

Consideration of quality of life has developed into an important concept of a patient-oriented medicine in the last 50 years. With it, it should be possible to capture the subjective experience of the patients and describe its different dimensions. Today, the quality of life as a patient-reported endpoint is also an integral part of the early benefit assessment under the German Drug Market Reorganization Act. Read More

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December 2018
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[Sirolimus for LAM - A New MILEStone Reached?]

Authors:
M Kreuter H Wirtz

Pneumologie 2018 Dec 12. Epub 2018 Dec 12.

Universitätsklinikum Leipzig, Abteilung Pneumologie.

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December 2018
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[Current trends in flexible ureteroscopy: an update].

Aktuelle Urol 2018 Dec 12. Epub 2018 Dec 12.

Department of Urology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg.

Flexible ureteroscopy (fURS) has become a success story in urology. Since its implementation into the treatment of urolithiasis, fURS has demonstrated excellent clinical performance and safety. In recent years, the spread of disposable ureteroscopes has shaped the field of endoscopic stone treatment. Read More

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December 2018
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