1,210 results match your criteria Vogt-Koyanagi-Harada Syndrome


[Investigation of the diagnostic value of anti-dense fine speckled 70/lens epithelium derived growth factor p75 autoantibody for autoimmune diseases].

Mikrobiyol Bul 2018 Oct;52(4):413-424

Ankara Training and Research Hospital, Clinic of Medical Microbiology, Ankara, Turkey.

Antinuclear antibodies (ANA) are the autoantibodies that are produced against nuclear antigens in the cell nucleus and/or cytoplasm, and are one of the important diagnostic criteria in systemic autoimmune rheumatic diseases (SARD). Until today, several methods have been developed for detecting ANA's. However, indirect immunofluorescence (IIF) technique, that is also known as one of the oldest methods, is still the most commonly used one. Read More

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October 2018

Choroidal biomarkers.

Indian J Ophthalmol 2018 Dec;66(12):1716-1726

Advanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

A structurally and functionally intact choroid tissue is vitally important for the retina function. Although central retinal artery is responsible to supply the inner retina, choroidal vein network is responsible for the remaining one-third of the external part. Abnormal choroidal blood flow leads to photoreceptor dysfunction and photoreceptor death in the retina, and the choroid has vital roles in the pathophysiology of many diseases such as central serous chorioretinopathy, age-related macular degeneration, pathologic myopia, Vogt-Koyanagi-Harada disease. Read More

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December 2018
5 Reads
0.930 Impact Factor

Association Study of ARMC9 Gene Variants with Vogt-Koyanagi-Harada Disease in Japanese Patients.

Ocul Immunol Inflamm 2018 Nov 5:1-7. Epub 2018 Nov 5.

a Department of Ophthalmology and Visual Science , Yokohama City University Graduate School of Medicine , Yokohama , Kanagawa , Japan.

Purpose: To investigate whether variants in the ARMC9 gene encoding KU-MEL-1 are associated with Vogt-Koyanagi-Harada (VKH) disease in a Japanese population.

Methods: We recruited 380 Japanese patients with VKH disease and 744 Japanese healthy controls to genotype seven single-nucleotide polymorphisms (SNPs) in ARMC9. We also performed imputation analysis of the ARMC9 region and 195 imputed SNPs were included in the statistical analysis. Read More

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November 2018
5 Reads

Aggressive treatment in paediatric or young patients with drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) is associated with future development of type III polyglandular autoimmune syndrome.

BMJ Case Rep 2018 Oct 27;2018. Epub 2018 Oct 27.

Department of Dermatology, Kawasaki Medical School, Kurashiki, Okayama, Japan.

We experienced a 6-year-old case of drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) with subsequent development autoimmune thyroiditis (Hashimoto's thyroiditis), type 1 diabetes with antithyroglobulin, thyroid peroxidase, insulinoma-associated antigen and anti-insulin antibodies at 4 months, alopecia at 7 months, vitiligo, uveitis due to Vogt-Koyanagi-Harada disease at 8 months after clinical resolution of the DiHS/DRESS. He was diagnosed as type III polyglandular autoimmune syndrome (PASIII) after DiHS/DRESS. Prompted by this case, we sought to determine which triggering factors were responsible for later development of PASIII in previously published cases with autoimmune sequelae. Read More

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October 2018
4 Reads

Update on Vertigo in Autoimmune Disorders, from Diagnosis to Treatment.

J Immunol Res 2018 26;2018:5072582. Epub 2018 Sep 26.

Department of Neurosciences, Otorhinolaryngology Unit, University of Padua, Via Giustiniani, 2, 35128 Padova, Italy.

The prevalence of autoimmune diseases has been increasing over the last 20 years. The clinical presentation of this large and heterogeneous group of disorders depends on whether the involvement is organ-specific or non-organ-specific. Dizziness, vertigo, and disequilibrium are common symptoms reported by patients with vestibulocochlear involvement. Read More

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September 2018
3 Reads

Probable Vogt-Koyanagi-Harada disease with granulomatous tattoo-related dermatitis.

Can J Ophthalmol 2018 Oct 7;53(5):e179-e182. Epub 2018 Mar 7.

University of Calgary, Calgary, Alberta; Calgary Retina Consultants, Calgary, Alberta.

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October 2018

Noninfectious uveitis in the Asia-Pacific region.

Eye (Lond) 2018 Oct 15. Epub 2018 Oct 15.

Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan.

Uveitis is a sight-threatening disease. Up to 35% of patients may have impaired vision. Inflammation of the uvea tissue has more than 60 etiologies. Read More

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October 2018
10 Reads
1.900 Impact Factor

A case of Vogt-Koyanagi-Harada disease as a sequela of drug reaction with eosinophilia and systemic symptoms.

JAAD Case Rep 2018 Oct 3;4(9):863-865. Epub 2018 Oct 3.

Department of Dermatology, University of Washington, Seattle Washington.

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October 2018
7 Reads

Clinical Characteristics and Treatment of 308 Panuveitis Patients over 10 Years: Results from the KKESH Uveitis Survey Study Group.

Ocul Immunol Inflamm 2018 Oct 10:1-9. Epub 2018 Oct 10.

b Vitreoretinal and Uveitis Division , King Khaled Eye Specialist Hospital , Riyadh , Kingdom of Saudi Arabia.

Purpose: To describe the clinical characteristics and surgical outcomes of panuveitis over a 10-year period.

Methods: Data were collected on panuveitis etiology, treatment, surgery and change in vision.

Results: Overall, 308 patients (594 eyes) were evaluated, 54. Read More

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October 2018
5 Reads

Disabled-2 (DAB2) Overexpression Inhibits Monocyte-Derived Dendritic Cells' Function in Vogt-Koyanagi-Harada Disease.

Invest Ophthalmol Vis Sci 2018 Sep;59(11):4662-4669

The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, People's Republic of China.

Purpose: Recent studies reported that the tumor suppressor disabled-2 (DAB2) is a negative regulator of immune function. In this study, we investigated the role of DAB2 in monocyte-derived dendritic cells (DCs) from Vogt-Koyanagi-Harada disease (VKH) patients.

Methods: The mRNA and protein levels of DAB2 were quantified by quantitative real-time PCR and Western blot. Read More

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September 2018
1 Read

Response to comment on: Rebound inflammation after an intravitreal injection in Vogt-Koyanagi-Harada syndrome.

Indian J Ophthalmol 2018 10;66(10):1523

Department of Vitreoretina, Dr. Shroff's Charity Eye Hospital, New Delhi, India.

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October 2018

Comment on: Rebound inflammation after an intravitreal injection in Vogt-Koyanagi-Harada syndrome.

Authors:
Manish Jain

Indian J Ophthalmol 2018 10;66(10):1522-1523

Department of Ophthalmology, NMC Specialty Hospital, Al Ain, UAE.

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October 2018

The CC chemokines CCL8, CCL13 and CCL20 are local inflammatory biomarkers of HLA-B27-associated uveitis.

Acta Ophthalmol 2018 Sep 21. Epub 2018 Sep 21.

Rega Institute for Medical Research, Department of Microbiology and Immunology, University of Leuven, KU Leuven, Leuven, Belgium.

Purpose: To determine the concentrations of the CC chemokines CCL2, CCL7, CCL8, CCL11, CCL13, CCL20, CCL24 and CCL26 in aqueous humour (AH) samples from patients with specific uveitic entities.

Methods: Aqueous humour samples from patients with active uveitis associated with Behçet's disease (BD) (n = 13), sarcoidosis (n = 8), HLA-B27-related inflammation (n = 12), Vogt-Koyanagi-Harada (VKH) disease (n = 12) and control patients (n = 9) were assayed with the use of a multiplex assay.

Results: When considering all uveitis patients as one group, all chemokine levels except CCL2 were significantly increased compared to controls. Read More

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September 2018
1 Read

Acquired disorders with depigmentation: A systematic approach to vitiliginoid conditions.

J Am Acad Dermatol 2018 Sep 17. Epub 2018 Sep 17.

Department of Dermatology and Pediatric Dermatology, Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatologic Institute, IRCCS, Via Elio Chianesi 53, Rome 00144, Italy.

Acquired disorders with depigmentation are commonly encountered by dermatologists and present with a wide differential diagnosis. Vitiligo, the most common disorder of acquired depigmentation, is characterized by well-defined depigmented macules and patches. Other conditions, such as chemical leukoderma, can present with similar findings, and are often easily mistaken for vitiligo. Read More

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September 2018
4 Reads

Outcome and Prognostic Factors of Phacoemulsification Cataract Surgery in Vogt-Koyanagi-Harada Uveitis.

Am J Ophthalmol 2018 Dec 6;196:121-128. Epub 2018 Sep 6.

The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, and Chongqing Eye Institute, Chongqing, China. Electronic address:

Purpose: To investigate visual outcome and prognostic factors following cataract surgery in patients with Vogt-Koyanagi-Harada (VKH) disease.

Design: Retrospective, interventional case series.

Methods: The history, clinical characteristics, best-corrected visual acuity (BCVA), full-field electroretinogram (ERG), intraocular inflammation, complications, and extraocular manifestations were analyzed retrospectively. Read More

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December 2018
6 Reads

Incomplete Vogt-Koyanagi-Harada disease following treatment with encorafenib and binimetinib for metastatic melanoma.

Melanoma Res 2018 Dec;28(6):648-651

Department of Internal Medicine, Laikon General Hospital.

Ophthalmological complications constitute a class effect of treatment with BRAF inhibitors. Encorafenib is a new BRAF inhibitor currently being tested in phase 3 clinical trials for advanced or metastatic melanoma as monotherapy or in combination with the MEK-inhibitor binimetinib. In this study, we present a case of severe bilateral panuveitis and neurosensory hearing loss in an elderly patient treated with encorafenib and binimetinib for metastatic BRAF-mutant melanoma. Read More

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December 2018
9 Reads

A challenging case of tuberculosis-associated uveitis after corticosteroid treatment for Vogt-Koyanagi-Harada disease.

Int J Ophthalmol 2018 18;11(8):1430-1432. Epub 2018 Aug 18.

Department of Ophthalmology, Shanghai General Hospital, Shanghai 200080, China.

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August 2018
1 Read

Optical Coherence Tomography Angiography for Evaluation of Sattler's Layer in Vogt-Koyanagi-Harada Disease.

Ophthalmic Surg Lasers Imaging Retina 2018 Aug;49(8):639-642

The authors report a case of acute Vogt-Koyanagi-Harada syndrome with massively impaired perfusion in the Sattler's layer on optical coherence tomography angiography (OCTA). The hypoperfusion fully resolved during a period of 4 weeks and correlated well with hypofluorescent spots on indocyanine green angiography. This is the first time reduced perfusion in Sattler's layer has been observed on OCTA. Read More

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Ultra-wide-field angiography findings in acute Vogt-Koyanagi-Harada disease.

Br J Ophthalmol 2018 Aug 12. Epub 2018 Aug 12.

Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

Background/aims: To investigate the prevalence of abnormal central and peripheral ultra-wide-field (UWF) angiography findings, and their association with clinical features in acute Vogt-Koyanagi-Harada (VKH) disease.

Methods: This retrospective, observational study included 26 eyes of 13 treatment-naïve patients with acute VKH disease who underwent UWF fluorescein angiography (FA). Sixteen eyes of eight patients also underwent UWF indocyanine green angiography (ICGA). Read More

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TUBERCULOUS CHOROIDITIS IN PATIENT WITH VOGT-KOYANAGI-HARADA DISEASE.

Retin Cases Brief Rep 2018 Aug 1. Epub 2018 Aug 1.

Department of Ophthalmology, Northwell Health System, Great Neck, New York.

Purpose: To describe a novel case of intraocular tuberculosis (TB) arising in a patient undergoing treatment for Vogt-Koyanagi-Harada disease, and to highlight the use of spectral domain optical coherence tomography for helping confirm the diagnosis and monitor treatment response.

Methods: Case report of a patient with Vogt-Koyanagi-Harada disease on prednisone, with acute clinical changes suspicious for bilateral tuberculous choroiditis. Spectral optical coherence tomography, fundus photography, and B-scan ultrasonography were all used to capture the acute lesions, and to monitor their responses after initiation of anti-TB therapy. Read More

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August 2018
6 Reads

Epidemiology of uveitis (2013-2015) and changes in the patterns of uveitis (2004-2015) in the central Tokyo area: a retrospective study.

BMC Ophthalmol 2018 Aug 2;18(1):189. Epub 2018 Aug 2.

Department of Ophthalmology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Background: The distribution of uveitis varies with genetic, ethnic, geographic, environmental, and lifestyle factors. Epidemiological information about the patterns of uveitis is useful when an ophthalmologist considers the diagnosis of uveitis. Therefore, it is important to identify the causes of uveitis over the years in different regions. Read More

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August 2018
2 Reads

SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY AND OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FINDINGS IN WAARDENBURG SYNDROME.

Retin Cases Brief Rep 2018 Jul 16. Epub 2018 Jul 16.

Vitreous Retina Macula Specialists of Toronto, Etobicoke, Ontario, Canada.

Purpose: Waardenburg syndrome (WS) is a rare condition characterized by six main features. It has been previously observed that WS is also associated with hypopigmentation of the choroid through multimodal imaging. To our knowledge, this is the first report of using swept-source optical coherence tomography angiography (OCTA) on a patient with known WS. Read More

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July 2018
1 Read

Long term treatment with infliximab in pediatric Vogt-Koyanagi-Harada disease.

Am J Ophthalmol Case Rep 2018 Sep 2;11:139-141. Epub 2018 Jul 2.

Rheumatology Department, Pedro de Elizalde Children General Hospital, Buenos Aires, Argentina.

Purpose: To report a case of pediatric Vogt-Koyanagi-Harada (VKH) successfully treated with infliximab and methotrexate for ten years.

Observations: A 9-year-old Hispanic girl with VKH disease, was successfully treated with oral methotrexate 15 mg/week and oral prednisone 40 mg/day (1mg/kg/day). But when oral prednisone was tapered to 10 mg/day over a 3-month period, inflammation recurred. Read More

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September 2018
2 Reads

Development and Evaluation of Diagnostic Criteria for Vogt-Koyanagi-Harada Disease.

JAMA Ophthalmol 2018 Sep;136(9):1025-1031

University Eye Clinic Maastricht, Maastricht, Limburg, the Netherlands.

Importance: To our knowledge, a set of well-defined diagnostic criteria is not yet developed for the diagnosis of Vogt-Koyanagi-Harada (VKH) disease.

Objective: To develop and evaluate a set of diagnostic criteria for VKH disease using data from Chinese patients.

Design, Setting, And Participants: This case-control study reviewed medical records of patients from a tertiary referral center between October 2011 and October 2016. Read More

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September 2018
9 Reads

Improving the Diagnostic Criteria for Vogt-Koyanagi-Harada Disease.

Authors:
Douglas A Jabs

JAMA Ophthalmol 2018 Sep;136(9):1032-1033

Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York.

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September 2018

Vogt-Koyanagi-Harada Disease Associated with Hepatitis B Vaccination.

Ocul Immunol Inflamm 2018 Jun 28:1-4. Epub 2018 Jun 28.

b Emory Eye Center, Department of Ophthalmology , Emory University School of Medicine , Atlanta , Georgia , USA.

Purpose: To report a case of Vogt-Koyanagi-Harada (VKH) disease associated with hepatitis B vaccination.

Methods: Case report.

Results: A 43-year-old Caucasian male presented with a three-week history of blurry vision, pain, photophobia, and redness in both eyes. Read More

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June 2018
7 Reads

Catching the therapeutic window of opportunity in early initial-onset Vogt-Koyanagi-Harada uveitis can cure the disease.

Int Ophthalmol 2018 Jun 11. Epub 2018 Jun 11.

Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Purpose: Vogt-Koyanagi-Harada (VKH) disease is a primary autoimmune granulomatous choroiditis that begins in the choroidal stroma. The aim of this review was to gather a body of evidence for the concept of a window of therapeutic opportunity, defined as a time interval following initial-onset disease during which adequate treatment will substantially modify the disease outcome and possibly even lead to cure, similar to what has been described for rheumatoid arthritis.

Methods: We reviewed the literature and consulted leading experts in VKH disease to determine the consensus for the notion of a therapeutic window of opportunity in VKH disease. Read More

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June 2018
7 Reads

Assessment of measurement methods of posterior inflammation in stromal choroiditis: the value of quantitative outcome measures versus the presently qualitatively based paradigm.

Int Ophthalmol 2018 Jun 26. Epub 2018 Jun 26.

Retinal and Inflammatory Eye Diseases, Centre for Ophthalmic Specialized Care (COS), Clinic Montchoisi Teaching Centre, Rue Charles-Monnard 6, 1003, Lausanne, Switzerland.

Purpose: To assess posterior inflammation using a fluorescein (FA)/indocyanine-green angiography (ICGA) scoring system, and compare them to the presently recommended outcome measure, the standardization of uveitis nomenclature vitreous haze score (SUN-VH) in stromal choroiditis.

Methods: This was a retrospective study on patients with a diagnosis of ocular sarcoidosis(OS), ocular tuberculosis(OT), Birdshot retinochoroiditis(BRC) and Vogt-Koyanagi-Harada disease(VKH) seen in the Centre for Ophthalmic Specialized Care, Lausanne, Switzerland. Angiography signs were quantified according to an established FA/ICGA scoring system. Read More

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June 2018
8 Reads

Increased Expression of IL-23 Receptor (IL-23R) in Vogt-Koyanagi-Harada (VKH) Disease.

Curr Eye Res 2018 Nov 18;43(11):1369-1373. Epub 2018 Jul 18.

a Chongqing Key Lab of Ophthalmology, Chongqing Eye Institute , The First Affiliated Hospital of Chongqing Medical University , Chongqing , P. R. China.

Objective: Vogt-Koyanagi-Harada (VKH) disease is an autoimmune disease mediated by T cells that target melanocytes. It has been shown that IL-23 receptor (IL-23R) signaling promotes the generation of pathogenic T helper 17 cells. The aim of this study was designed to detect the possible role of IL-23R in VKH disease. Read More

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November 2018
9 Reads
1.663 Impact Factor

Rebound inflammation after an intravitreal injection in Vogt-Koyanagi-Harada syndrome.

Indian J Ophthalmol 2018 06;66(6):863-865

Department of Vitreo-retina, Dr Shroff's Charity Eye Hospital, New Delhi, India.

A 43-year-old male with chronic Vogt-Koyanagi-Harada syndrome (VKH) presented with subfoveal choroidal neovascular membrane (CNVM) in the right eye with no evidence of active inflammation. He underwent intravitreal bevacizumab and dexamethasone injections. Postinjection he developed fresh keratic precipitates and exudative retinal detachment (RD). Read More

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June 2018
2 Reads

Vogt-Koyanagi-Harada disease like presentation in patients with chronic myeloid leukemia.

Am J Ophthalmol Case Rep 2018 Jun 10;10:221-225. Epub 2018 Mar 10.

Sankara Nethralaya, Medical Research Foundation, Chennai, India.

Purpose: To report two rare cases of chronic myeloid leukemia (CML) on tyrosine kinase inhibitors presenting as bilateral serous retinal detachment and ocular inflammation, simulating Vogt-Koyanagi-Harada (VKH) disease.

Methods: Case series and review of literature.

Result: Two young patients (one male and one female) with CML on treatment with tyrosine kinase inhibitors (imatinib and dasatanib) under remission presented with bilateral sudden vision loss. Read More

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June 2018
10 Reads

Vogt-Koyanagi-Harada disease: study of 14 cases.

Med Clin (Barc) 2018 May 4. Epub 2018 May 4.

Servicio de Reumatología, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, Las Palmas, España.

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May 2018
2 Reads

Vogt-Koyanagi-Harada Syndrome Induced by Pembrolizumab in a Patient with Non-Small Cell Lung Cancer.

J Thorac Oncol 2018 Oct 3;13(10):1606-1607. Epub 2018 May 3.

Department of Respiratory Medicine, Iwakuni Clinical Center, Iwakuni, Japan.

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October 2018
2 Reads

[A rare case of ocular scarrings in a patient with Vogt-Koyanagi-Harada disease].

Pan Afr Med J 2017 22;28:313. Epub 2017 Dec 22.

Université Mohamed V Souissi, Service d'Ophtalmologie A, Hôpital des Spécialités, CHU IBN Sina, Rabat, Maroc.

We here report the case of a 27-year old patient, followed-up in our Department for treatment of chronic Vogt-Koyanagi-Harada disease ( VKH disease). Fundus examination showed depigmentation of the retinal pigment epithelium and of the choroid, appearing as a pseudotumoral peripapillary lesion. Vogt-Koyanagi-Harada disease is a multisystem disorder, characterized by bilateral granulomatous panuveitis with serous exudative multifocal retinal detachment. Read More

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May 2018
5 Reads

Intraocular Lens Calcification: Clinico-pathological Report of Two Cases and Literature Review.

J Ophthalmic Vis Res 2018 Apr-Jun;13(2):195-199

Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: We report the clinicopathological features and surgical outcomes of two cases of intraocular lens (IOL) calcification along with a review of the current literature.

Case Report: The first patient was a 53-year-old woman with diabetes mellitus (type 2) who underwent phacoemulsification with posterior chamber IOL insertion (PCIOL), and pars plana vitrectomy. Significant clouding of the IOL was first noted after 1. Read More

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May 2018
2 Reads

Patterns of Uveitis at a Tertiary Referral Center in Northeastern Iran.

J Ophthalmic Vis Res 2018 Apr-Jun;13(2):138-143

Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Purpose: To describe the demographic and clinical patterns of patients with uveitis referred to a tertiary center in northeastern Iran.

Methods: This cross-sectional retrospective study included 235 patients with uveitis who had been referred to the uveitis clinic of Khatam-Al-Anbia eye hospital, affiliated to Mashhad University of Medical Sciences, from February 2013 to March 2014. Data regarding patient age, sex, anatomical location of the disease, and etiologic and clinical features were analyzed. Read More

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May 2018
4 Reads

Differential CXC and CX3C Chemokine Expression Profiles in Aqueous Humor of Patients With Specific Endogenous Uveitic Entities.

Invest Ophthalmol Vis Sci 2018 May;59(6):2222-2228

Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, KU Leuven, Leuven, Belgium.

Purpose: To determine the levels of the neutrophil chemoattractants CXCL1, CXCL2, CXCL5, CXCL6, and CXCL8, the T helper 1 chemoattractants CXCL9, CXCL10 and CXCL11, the lymphoid chemokines CXCL12 and CXCL13 and the soluble form of the transmembrane chemokines CXCL16 and CX3CL1, in aqueous humor samples from patients with specific uveitic entities.

Methods: Aqueous humor samples from patients with active uveitis associated with Behçet's disease (n = 13), sarcoidosis (n = 8), HLA-B27-related inflammation (n = 12), Vogt-Koyanagi-Harada (VKH) disease (n = 12), and healthy controls (n = 9) were assayed with the use of a multiplex assay.

Results: All chemoattractant levels were significantly higher in all patients than in the controls. Read More

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May 2018
15 Reads

Longitudinal Study of Visual Function in Vogt-Koyanagi-Harada Disease Using Full-Field Electroretinography.

Am J Ophthalmol 2018 Jul 25;191:92-99. Epub 2018 Apr 25.

Ophthalmology Department, Chongqing Key Lab of Ophthalmology, Chongqing Eye Institute, The First Affiliated Hospital of Chongqing Medical University, Chongqing, P.R. China. Electronic address:

Purpose: To investigate the dynamic changes of full-field electroretinography (ffERG) and its relationship with structural changes in Vogt-Koyanagi-Harada (VKH) disease.

Design: Interventional case series.

Methods: A total of 42 VKH patients (84 eyes) and 45 normal controls (90 eyes) were included in this study. Read More

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July 2018
3 Reads

Decreased expression of A20 is associated with ocular Behcet's disease (BD) but not with Vogt-Koyanagi-Harada (VKH) disease.

Br J Ophthalmol 2018 Aug 26;102(8):1167-1172. Epub 2018 Apr 26.

The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, China

Purpose: A20 is a ubiquitously expressed and inducible cytosolic protein, which plays an important role in the negative regulation of inflammation and immunity. In this study, we investigated the role of A20 in Behcet's disease (BD) and Vogt-Koyanagi-Harada (VKH) disease.

Methods: The levels of A20 in peripheral blood mononuclear cells (PBMCs) and dendritic cells (DCs) were detected in BD patients with active and inactive uveitis, VKH patients with active and inactive uveitis, and normal subjects, respectively, by real-time PCR. Read More

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August 2018
6 Reads

Unusual Case of Vogt-Koyanagi-Harada Disease Associated with SAPHO Syndrome: A Case Report.

Case Rep Ophthalmol 2018 Jan-Apr;9(1):202-208. Epub 2018 Mar 29.

Aichi Medical University, Department of Ophthalmology, Nagakute City, Japan.

A 66-year-old Japanese woman who was diagnosed with synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome presented with bilateral blurred vision 4 months prior to visiting our hospital. She had visited a local ophthalmology clinic first. She was diagnosed with conjunctivitis and was prescribed antibacterial eye drops. Read More

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March 2018
1 Read

Need for Quantitative Measurement Methods for Posterior Uveitis: Comparison of Dual FA/ICGA Angiography, EDI-OCT Choroidal Thickness and SUN Vitreous Haze Evaluation in Stromal Choroiditis.

Klin Monbl Augenheilkd 2018 Apr 18;235(4):424-435. Epub 2018 Apr 18.

Ophthalmology, Retinal and Inflammatory Eye Diseases, Centre for Ophthalmic Specialized Care (COS), Clinic Montchoisi Teaching Centre, Lausanne, Switzerland.

Background/purpose: Quantitative methods for posterior uveitis are necessary for precise appraisal and follow-up of inflammation in practice and in clinical trials. The aim of this study was to assess fluorescein angiography (FA), indocanine green angiography (ICGA), and enhanced depth imaging optical coherence tomography choroidal thickness (EDI-OCT CT) in two stromal choroiditis entities, birdshot retinochoroiditis (BRC), and Vogt-Koyanagi-Harada disease (VKH), as well as to determine (1) disease patterns, (2) respective response to therapy, and (3) their potential utility in clinical trials in comparison to vitreous haze, the present standard outcome used in clinical trials.

Methods: This retrospective study included newly diagnosed patients with BRC and VKH, seen at the Centre for Ophthalmic Specialized Care, Lausanne, Switzerland. Read More

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April 2018
14 Reads

Clinical features and visual outcomes of 111 patients with new-onset acute Vogt-Koyanagi-Harada disease treated with pulse intravenous corticosteroids.

Br J Ophthalmol 2018 Apr 17. Epub 2018 Apr 17.

Department of Ophthalmology, Kyorin University School of Medicine, Tokyo, Japan

Purpose: To describe the clinical features, treatment and visual outcomes of Japanese patients with new-onset acute Vogt-Koyanagi-Harada (VKH) disease.

Methods: Clinical records of 111 patients who presented between 1999 and 2015 to the Ocular Inflammation Service of the Kyorin Eye Center, Tokyo, were reviewed.

Results: Of the 111 patients (68 women, 43 men), 16 had complete, 90 had incomplete and 5 had probable VKH disease. Read More

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April 2018
3 Reads

Did poor eyesight influence Goya's late works? Medicine and art history in search for an interpretation of Goya's late paintings.

Acta Ophthalmol 2018 Sep 15;96(6):652-654. Epub 2018 Apr 15.

Official School of Languages n.1, Zaragoza, Spain.

Purpose: The aim of this article is to 'determine' the scope of Goya's eyesight difficulties and assess the extent to which those difficulties might explain his style of painting in the last years of his life.

Methods: We analyse the correspondence and late works of the Aragonese painter Francisco de Goya y Lucientes (1746-1828), who has been admired for his use of colour, his energetic loose brushstrokes, his disregard for details and his bold compositions, as well as for his different artistic styles throughout his life.

Results: The evolution of Goya's style of painting in his later works seems to have been the consequence of an eyesight condition, probably age-related cataracts at an advanced stage. Read More

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September 2018
5 Reads

Bilateral vestibular impairment in Vogt Koyanagi Harada syndrome: a case report.

Neurol Sci 2018 09 13;39(9):1609-1611. Epub 2018 Apr 13.

DMC University of Insubria, Varese; Neurology Unit, ASST 7 laghi, via Guicciardini 9, 21100, Varese, Italy.

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September 2018
1 Read

A Case of Vogt-Koyanagi-Harada Syndrome Mimicking Optic Neuritis.

J Coll Physicians Surg Pak 2018 Apr;28(4):325-326

Department of Ophthalmology, Al-Khidmat Teaching Hospital, Mansoora / University College of Medicine and Dentistry, University of Lahore, Lahore.

Vogt-Koyanagi-Harada syndrome is a rare disease that occurs commonly in pigmented individuals of Asian origin. A 25-year female presented in medical outpatient department (OPD) of Al-Khidmat Teaching Hospital, Mansoora, Lahore with headache and neck stiffness. She was referred to eye OPD for the complaint of decreased vision. Read More

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April 2018
5 Reads

Late onset acute Vogt-Koyanagi-Harada syndrome-challenges on the way.

Int J Ophthalmol 2018 18;11(3):524-527. Epub 2018 Mar 18.

Department of Ophthalmology and Visual Sciences, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Rua Botucatu, 821, Vila Clementino, São Paulo, SP 04023-062, Brazil.

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Retinal Pigment Epithelium Detachment in Acute Vogt-Koyanagi-Harada Disease: An Unusual Finding at Presentation.

Ocul Immunol Inflamm 2018 Mar 7:1-4. Epub 2018 Mar 7.

a Department of Ophthalmology, Fattouma Bourguiba University Hospital, Faculty of Medicine , University of Monastir , Monastir , Tunisia.

Purpose: To report the cases of two patients who presented with acute Vogt-Koyanagi-Harada (VKH) disease and associated retinal pigment epithelium detachment (PED).

Methods: 2 case reports. Case 1: A 22-year-old male patient complained of acute bilateral decrease in vision. Read More

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March 2018
8 Reads

Decreased interleukin(IL)-35 Expression is Associated with Active Intraocular Inflammation in Vogt-Koyanagi-Harada(VKH) Disease.

Ocul Immunol Inflamm 2018 Mar 2:1-7. Epub 2018 Mar 2.

a The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Lab of Ophthalmology, Chongqing Eye Institute , Chongqing , P. R. China.

Purpose: Recent studies have reported that IL-35 has a protective effect in autoimmune disease. In this study, we explored the role of IL-35 in the pathogenesis of Vogt-Koyanagi-Harada (VKH) disease.

Methods: The IL-35/EBI3 and IL-35/P35 mRNA level was assayed by Real-Time PCR. Read More

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March 2018
4 Reads
1.440 Impact Factor

Association of Long Noncoding RNAs Polymorphisms With Ankylosing Spondylitis, Vogt-Koyanagi-Harada Disease, and Behcet's Disease.

Invest Ophthalmol Vis Sci 2018 02;59(2):1158-1166

The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, Chongqing Eye Institute, Chongqing, China.

Purpose: Long noncoding RNAs (lncRNAs) are emerging as important regulators of inflammatory immune responses, whereby genetic variants may affect this biologic function. This study aimed to investigate the association of 110 single nucleotide polymorphisms (SNPs) of lncRNAs, known to be associated with autoimmune disease, in patients with ocular Vogt-Koyanagi-Harada (VKH) disease, Behcet's disease (BD), and acute anterior uveitis (AAU) with or without ankylosing spondylitis (AS).

Methods: A two-stage case-control study was performed on 1626 VKH patients, 384 BD patients, 624 AAU with AS, 751 AAU without AS, 720 AS without AAU, and 3305 healthy subjects. Read More

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February 2018
4 Reads