1,333 results match your criteria Vogt-Koyanagi-Harada Syndrome


Long-term outcomes of cataract surgery in children with uveitis.

Indian J Ophthalmol 2019 Apr;67(4):490-495

Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, India.

Purpose: To evaluate the long-term outcomes of cataract surgery in children with uveitis.

Methods: Retrospective, noncomparative review of medical records of children (≤16 years) with uveitic cataract who had undergone cataract surgery between January 2001 and December 2014 at a tertiary care center was done. The main outcome measures were visual acuity and postoperative complications. Read More

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http://dx.doi.org/10.4103/ijo.IJO_846_18DOI Listing
April 2019
3 Reads
0.927 Impact Factor

Vogt-Koyanagi-Harada syndrome: what neurologists need to know.

Pract Neurol 2019 Mar 19. Epub 2019 Mar 19.

Neurology, The Canberra Hospital, Canberra, Australian Capital Territory, Australia

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http://dx.doi.org/10.1136/practneurol-2018-002165DOI Listing

Immune-mediated conditions affecting the brain, eye and ear (BEE syndromes).

J Neurol Neurosurg Psychiatry 2019 Mar 9. Epub 2019 Mar 9.

Neuroimmunology Clinic, Concord Hospital, University of Sydney, Sydney, NSW, Australia

The triad of central nervous system symptoms, visual disturbance and hearing impairment is an oft-encountered clinical scenario. A number of immune-mediated diseases should be considered among the differential diagnoses including: Susac syndrome, Cogan syndrome or Vogt-Koyanagi-Harada disease; demyelinating conditions such as multiple sclerosis or neuromyelitis optica spectrum disorder; systemic diseases such as systemic lupus erythematosus, Sjögren syndrome or Behcet disease and granulomatous diseases such as sarcoidosis. In this article, we coin the term 'BEE syndromes' to draw attention to the various immune-mediated diseases that affect the brain, eye and ear. Read More

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http://jnnp.bmj.com/lookup/doi/10.1136/jnnp-2018-319002
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http://dx.doi.org/10.1136/jnnp-2018-319002DOI Listing
March 2019
20 Reads

Real-world evidence of treatment for relapse of noninfectious uveitis in tertiary centers in Japan: A multicenter study.

Medicine (Baltimore) 2019 Mar;98(9):e14668

Department of Ophthalmology & Visual Science, Tokyo Medical and Dental University Graduate School of Medicine.

Noninfectious uveitis (NIU), which pathogenesis is often autoimmune nature, occurs as a symptom of systemic syndromes or only in the eye. The standard treatment of NIU is local, topical, and oral administration of corticosteroids (CS) in combination with immunomodulatory therapy (IMT). However, additional therapeutic strategies involving topical and systemic administration of CS or others to treat relapse or exacerbation of ocular inflammation in NIU which present as various ocular manifestations have not been established. Read More

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http://dx.doi.org/10.1097/MD.0000000000014668DOI Listing
March 2019
2 Reads

Acute retinal necrosis (ARN) following chickenpox in a patient of Vogt-Koyanagi-Harada (VKH) syndrome using immunosuppressants.

BMJ Case Rep 2018 Nov 28;11(1). Epub 2018 Nov 28.

Smt. Kanuri Santhamma Centre for Vitreo Retinal Diseases, LV Prasad Eye Institute, Hyderabad, India.

A 36-year-old woman presented with diminution of vision and floaters in both the eyes. Both eyes had disc oedema, multiple pockets of neurosensory detachments along with vitritis. Fluorescein angiography and optical coherence tomography showed characteristic features of Vogt-Koyanagi-Harada (VKH) syndrome (figure 1). Read More

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http://dx.doi.org/10.1136/bcr-2018-227290DOI Listing
November 2018

[Investigation of the diagnostic value of anti-dense fine speckled 70/lens epithelium derived growth factor p75 autoantibody for autoimmune diseases].

Mikrobiyol Bul 2018 Oct;52(4):413-424

Ankara Training and Research Hospital, Clinic of Medical Microbiology, Ankara, Turkey.

Antinuclear antibodies (ANA) are the autoantibodies that are produced against nuclear antigens in the cell nucleus and/or cytoplasm, and are one of the important diagnostic criteria in systemic autoimmune rheumatic diseases (SARD). Until today, several methods have been developed for detecting ANA's. However, indirect immunofluorescence (IIF) technique, that is also known as one of the oldest methods, is still the most commonly used one. Read More

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http://dx.doi.org/10.5578/mb.67385DOI Listing
October 2018
4 Reads

Aggressive treatment in paediatric or young patients with drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) is associated with future development of type III polyglandular autoimmune syndrome.

BMJ Case Rep 2018 Oct 27;2018. Epub 2018 Oct 27.

Department of Dermatology, Kawasaki Medical School, Kurashiki, Okayama, Japan.

We experienced a 6-year-old case of drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) with subsequent development autoimmune thyroiditis (Hashimoto's thyroiditis), type 1 diabetes with antithyroglobulin, thyroid peroxidase, insulinoma-associated antigen and anti-insulin antibodies at 4 months, alopecia at 7 months, vitiligo, uveitis due to Vogt-Koyanagi-Harada disease at 8 months after clinical resolution of the DiHS/DRESS. He was diagnosed as type III polyglandular autoimmune syndrome (PASIII) after DiHS/DRESS. Prompted by this case, we sought to determine which triggering factors were responsible for later development of PASIII in previously published cases with autoimmune sequelae. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22552
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http://dx.doi.org/10.1136/bcr-2018-225528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214396PMC
October 2018
11 Reads

Update on Vertigo in Autoimmune Disorders, from Diagnosis to Treatment.

J Immunol Res 2018 26;2018:5072582. Epub 2018 Sep 26.

Department of Neurosciences, Otorhinolaryngology Unit, University of Padua, Via Giustiniani, 2, 35128 Padova, Italy.

The prevalence of autoimmune diseases has been increasing over the last 20 years. The clinical presentation of this large and heterogeneous group of disorders depends on whether the involvement is organ-specific or non-organ-specific. Dizziness, vertigo, and disequilibrium are common symptoms reported by patients with vestibulocochlear involvement. Read More

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http://dx.doi.org/10.1155/2018/5072582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178164PMC
December 2018
7 Reads

A case of Vogt-Koyanagi-Harada disease as a sequela of drug reaction with eosinophilia and systemic symptoms.

JAAD Case Rep 2018 Oct 3;4(9):863-865. Epub 2018 Oct 3.

Department of Dermatology, University of Washington, Seattle Washington.

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https://linkinghub.elsevier.com/retrieve/pii/S23525126183017
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http://dx.doi.org/10.1016/j.jdcr.2018.06.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172437PMC
October 2018
9 Reads

Disabled-2 (DAB2) Overexpression Inhibits Monocyte-Derived Dendritic Cells' Function in Vogt-Koyanagi-Harada Disease.

Invest Ophthalmol Vis Sci 2018 09;59(11):4662-4669

The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, People's Republic of China.

Purpose: Recent studies reported that the tumor suppressor disabled-2 (DAB2) is a negative regulator of immune function. In this study, we investigated the role of DAB2 in monocyte-derived dendritic cells (DCs) from Vogt-Koyanagi-Harada disease (VKH) patients.

Methods: The mRNA and protein levels of DAB2 were quantified by quantitative real-time PCR and Western blot. Read More

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http://dx.doi.org/10.1167/iovs.18-24630DOI Listing
September 2018
10 Reads

Response to comment on: Rebound inflammation after an intravitreal injection in Vogt-Koyanagi-Harada syndrome.

Indian J Ophthalmol 2018 10;66(10):1523

Department of Vitreoretina, Dr. Shroff's Charity Eye Hospital, New Delhi, India.

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http://dx.doi.org/10.4103/ijo.IJO_1221_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173022PMC
October 2018
1 Read

Comment on: Rebound inflammation after an intravitreal injection in Vogt-Koyanagi-Harada syndrome.

Authors:
Manish Jain

Indian J Ophthalmol 2018 10;66(10):1522-1523

Department of Ophthalmology, NMC Specialty Hospital, Al Ain, UAE.

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http://dx.doi.org/10.4103/ijo.IJO_980_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173042PMC
October 2018
1 Read

Acquired disorders with depigmentation: A systematic approach to vitiliginoid conditions.

J Am Acad Dermatol 2019 May 17;80(5):1215-1231.e6. Epub 2018 Sep 17.

Department of Dermatology and Pediatric Dermatology, Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatologic Institute, IRCCS, Rome, Italy.

Acquired disorders with depigmentation are commonly encountered by dermatologists and present with a wide differential diagnosis. Vitiligo, the most common disorder of acquired depigmentation, is characterized by well-defined depigmented macules and patches. Other conditions, such as chemical leukoderma, can present with similar findings, and are often easily mistaken for vitiligo. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183250
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http://dx.doi.org/10.1016/j.jaad.2018.03.063DOI Listing
May 2019
8 Reads

Optical Coherence Tomography Angiography for Evaluation of Sattler's Layer in Vogt-Koyanagi-Harada Disease.

Ophthalmic Surg Lasers Imaging Retina 2018 08;49(8):639-642

The authors report a case of acute Vogt-Koyanagi-Harada syndrome with massively impaired perfusion in the Sattler's layer on optical coherence tomography angiography (OCTA). The hypoperfusion fully resolved during a period of 4 weeks and correlated well with hypofluorescent spots on indocyanine green angiography. This is the first time reduced perfusion in Sattler's layer has been observed on OCTA. Read More

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http://dx.doi.org/10.3928/23258160-20180803-14DOI Listing
August 2018
3 Reads

Art is long, life is short. Francisco José de Goya y Lucientes (1746-1828), the suffering artist.

Med Hypotheses 2018 Aug 25;117:16-20. Epub 2018 May 25.

Psychiatry Unit, Hospital of Versilia, Lido di Camaiore, Lu, Italy.

Francisco José de Goya y Lucientes is one of the major figures of European art. From royal portraits to bizarre, grotesque illustrations, his legacy demonstrates a tortured genius, generating some of the most compelling art ever produced. His story is also the story of Spain during one of the most tumultuous passages of its history. Read More

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http://dx.doi.org/10.1016/j.mehy.2018.05.017DOI Listing
August 2018
1 Read
1.152 Impact Factor

SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY AND OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FINDINGS IN WAARDENBURG SYNDROME.

Retin Cases Brief Rep 2018 Jul 16. Epub 2018 Jul 16.

Vitreous Retina Macula Specialists of Toronto, Etobicoke, Ontario, Canada.

Purpose: Waardenburg syndrome (WS) is a rare condition characterized by six main features. It has been previously observed that WS is also associated with hypopigmentation of the choroid through multimodal imaging. To our knowledge, this is the first report of using swept-source optical coherence tomography angiography (OCTA) on a patient with known WS. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000783DOI Listing
July 2018
2 Reads

Long term treatment with infliximab in pediatric Vogt-Koyanagi-Harada disease.

Am J Ophthalmol Case Rep 2018 Sep 2;11:139-141. Epub 2018 Jul 2.

Rheumatology Department, Pedro de Elizalde Children General Hospital, Buenos Aires, Argentina.

Purpose: To report a case of pediatric Vogt-Koyanagi-Harada (VKH) successfully treated with infliximab and methotrexate for ten years.

Observations: A 9-year-old Hispanic girl with VKH disease, was successfully treated with oral methotrexate 15 mg/week and oral prednisone 40 mg/day (1mg/kg/day). But when oral prednisone was tapered to 10 mg/day over a 3-month period, inflammation recurred. Read More

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http://dx.doi.org/10.1016/j.ajoc.2018.06.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037902PMC
September 2018
3 Reads

Ahmed glaucoma drainage implant surgery in the management of refractory uveitic glaucoma: Long-term follow up.

Arch Soc Esp Oftalmol 2018 Sep 30;93(9):431-438. Epub 2018 Jun 30.

Fundación Oftalmológica Los Andes, Vitacura, Santiago de Chile, España. Electronic address:

Objective: To examine the long-term efficacy, safety and complications of Ahmed glaucoma drainage implant surgery in patients with refractory uveitic glaucoma.

Methods: Retrospective review of consecutive cases of patients with refractory uveitic glaucoma who underwent Ahmed glaucoma drainage implant surgery between 2004-2014. Demographic characteristics of the study population, visual acuity, intraocular pressure (IOP), number of antiglaucoma medications and operative and postoperative complications were recorded. Read More

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http://dx.doi.org/10.1016/j.oftal.2018.05.011DOI Listing
September 2018
4 Reads

Rebound inflammation after an intravitreal injection in Vogt-Koyanagi-Harada syndrome.

Indian J Ophthalmol 2018 06;66(6):863-865

Department of Vitreo-retina, Dr Shroff's Charity Eye Hospital, New Delhi, India.

A 43-year-old male with chronic Vogt-Koyanagi-Harada syndrome (VKH) presented with subfoveal choroidal neovascular membrane (CNVM) in the right eye with no evidence of active inflammation. He underwent intravitreal bevacizumab and dexamethasone injections. Postinjection he developed fresh keratic precipitates and exudative retinal detachment (RD). Read More

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http://dx.doi.org/10.4103/ijo.IJO_1145_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989520PMC
June 2018
3 Reads

Vogt-Koyanagi-Harada Syndrome Induced by Pembrolizumab in a Patient with Non-Small Cell Lung Cancer.

J Thorac Oncol 2018 Oct 3;13(10):1606-1607. Epub 2018 May 3.

Department of Respiratory Medicine, Iwakuni Clinical Center, Iwakuni, Japan.

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http://dx.doi.org/10.1016/j.jtho.2018.04.026DOI Listing
October 2018
3 Reads

[A rare case of ocular scarrings in a patient with Vogt-Koyanagi-Harada disease].

Pan Afr Med J 2017 22;28:313. Epub 2017 Dec 22.

Université Mohamed V Souissi, Service d'Ophtalmologie A, Hôpital des Spécialités, CHU IBN Sina, Rabat, Maroc.

We here report the case of a 27-year old patient, followed-up in our Department for treatment of chronic Vogt-Koyanagi-Harada disease ( VKH disease). Fundus examination showed depigmentation of the retinal pigment epithelium and of the choroid, appearing as a pseudotumoral peripapillary lesion. Vogt-Koyanagi-Harada disease is a multisystem disorder, characterized by bilateral granulomatous panuveitis with serous exudative multifocal retinal detachment. Read More

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http://www.panafrican-med-journal.com/content/article/28/313
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http://dx.doi.org/10.11604/pamj.2017.28.313.4547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927560PMC
May 2018
12 Reads

Intraocular Lens Calcification: Clinico-pathological Report of Two Cases and Literature Review.

J Ophthalmic Vis Res 2018 Apr-Jun;13(2):195-199

Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: We report the clinicopathological features and surgical outcomes of two cases of intraocular lens (IOL) calcification along with a review of the current literature.

Case Report: The first patient was a 53-year-old woman with diabetes mellitus (type 2) who underwent phacoemulsification with posterior chamber IOL insertion (PCIOL), and pars plana vitrectomy. Significant clouding of the IOL was first noted after 1. Read More

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http://dx.doi.org/10.4103/jovr.jovr_36_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905315PMC
May 2018
4 Reads

Patterns of Uveitis at a Tertiary Referral Center in Northeastern Iran.

J Ophthalmic Vis Res 2018 Apr-Jun;13(2):138-143

Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Purpose: To describe the demographic and clinical patterns of patients with uveitis referred to a tertiary center in northeastern Iran.

Methods: This cross-sectional retrospective study included 235 patients with uveitis who had been referred to the uveitis clinic of Khatam-Al-Anbia eye hospital, affiliated to Mashhad University of Medical Sciences, from February 2013 to March 2014. Data regarding patient age, sex, anatomical location of the disease, and etiologic and clinical features were analyzed. Read More

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http://dx.doi.org/10.4103/jovr.jovr_67_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905306PMC
May 2018
6 Reads

Decreased expression of A20 is associated with ocular Behcet's disease (BD) but not with Vogt-Koyanagi-Harada (VKH) disease.

Br J Ophthalmol 2018 08 26;102(8):1167-1172. Epub 2018 Apr 26.

The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, China

Purpose: A20 is a ubiquitously expressed and inducible cytosolic protein, which plays an important role in the negative regulation of inflammation and immunity. In this study, we investigated the role of A20 in Behcet's disease (BD) and Vogt-Koyanagi-Harada (VKH) disease.

Methods: The levels of A20 in peripheral blood mononuclear cells (PBMCs) and dendritic cells (DCs) were detected in BD patients with active and inactive uveitis, VKH patients with active and inactive uveitis, and normal subjects, respectively, by real-time PCR. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2017-311707DOI Listing
August 2018
8 Reads

Unusual Case of Vogt-Koyanagi-Harada Disease Associated with SAPHO Syndrome: A Case Report.

Case Rep Ophthalmol 2018 Jan-Apr;9(1):202-208. Epub 2018 Mar 29.

Aichi Medical University, Department of Ophthalmology, Nagakute City, Japan.

A 66-year-old Japanese woman who was diagnosed with synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome presented with bilateral blurred vision 4 months prior to visiting our hospital. She had visited a local ophthalmology clinic first. She was diagnosed with conjunctivitis and was prescribed antibacterial eye drops. Read More

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http://dx.doi.org/10.1159/000487226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903130PMC
March 2018
2 Reads

Did poor eyesight influence Goya's late works? Medicine and art history in search for an interpretation of Goya's late paintings.

Acta Ophthalmol 2018 Sep 15;96(6):652-654. Epub 2018 Apr 15.

Official School of Languages n.1, Zaragoza, Spain.

Purpose: The aim of this article is to 'determine' the scope of Goya's eyesight difficulties and assess the extent to which those difficulties might explain his style of painting in the last years of his life.

Methods: We analyse the correspondence and late works of the Aragonese painter Francisco de Goya y Lucientes (1746-1828), who has been admired for his use of colour, his energetic loose brushstrokes, his disregard for details and his bold compositions, as well as for his different artistic styles throughout his life.

Results: The evolution of Goya's style of painting in his later works seems to have been the consequence of an eyesight condition, probably age-related cataracts at an advanced stage. Read More

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http://dx.doi.org/10.1111/aos.13730DOI Listing
September 2018
8 Reads

Bilateral vestibular impairment in Vogt Koyanagi Harada syndrome: a case report.

Neurol Sci 2018 09 13;39(9):1609-1611. Epub 2018 Apr 13.

DMC University of Insubria, Varese; Neurology Unit, ASST 7 laghi, via Guicciardini 9, 21100, Varese, Italy.

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http://dx.doi.org/10.1007/s10072-018-3410-6DOI Listing
September 2018
7 Reads

A Case of Vogt-Koyanagi-Harada Syndrome Mimicking Optic Neuritis.

J Coll Physicians Surg Pak 2018 Apr;28(4):325-326

Department of Ophthalmology, Al-Khidmat Teaching Hospital, Mansoora / University College of Medicine and Dentistry, University of Lahore, Lahore.

Vogt-Koyanagi-Harada syndrome is a rare disease that occurs commonly in pigmented individuals of Asian origin. A 25-year female presented in medical outpatient department (OPD) of Al-Khidmat Teaching Hospital, Mansoora, Lahore with headache and neck stiffness. She was referred to eye OPD for the complaint of decreased vision. Read More

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http://dx.doi.org/10.29271/jcpsp.2018.04.325DOI Listing
April 2018
6 Reads

Late onset acute Vogt-Koyanagi-Harada syndrome-challenges on the way.

Int J Ophthalmol 2018 18;11(3):524-527. Epub 2018 Mar 18.

Department of Ophthalmology and Visual Sciences, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Rua Botucatu, 821, Vila Clementino, São Paulo, SP 04023-062, Brazil.

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http://dx.doi.org/10.18240/ijo.2018.03.27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861247PMC
March 2018
1 Read

Association of Long Noncoding RNAs Polymorphisms With Ankylosing Spondylitis, Vogt-Koyanagi-Harada Disease, and Behcet's Disease.

Invest Ophthalmol Vis Sci 2018 02;59(2):1158-1166

The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, Chongqing Eye Institute, Chongqing, China.

Purpose: Long noncoding RNAs (lncRNAs) are emerging as important regulators of inflammatory immune responses, whereby genetic variants may affect this biologic function. This study aimed to investigate the association of 110 single nucleotide polymorphisms (SNPs) of lncRNAs, known to be associated with autoimmune disease, in patients with ocular Vogt-Koyanagi-Harada (VKH) disease, Behcet's disease (BD), and acute anterior uveitis (AAU) with or without ankylosing spondylitis (AS).

Methods: A two-stage case-control study was performed on 1626 VKH patients, 384 BD patients, 624 AAU with AS, 751 AAU without AS, 720 AS without AAU, and 3305 healthy subjects. Read More

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http://dx.doi.org/10.1167/iovs.17-23247DOI Listing
February 2018
10 Reads

Positron emission tomography/computed tomography scan of Vogt-Koyanagi-Harada syndrome with associated autoimmune thyroid disease: A case report and literature review.

Medicine (Baltimore) 2018 Mar;97(9):e0047

Department of Ophthalmology, Tri-Service General Hospital.

Rationale: Vogt-Koyanagi-Harada (VKH) syndrome is a rare disease and could be associated with autoimmune thyroid disease (AITD). This report was aimed to investigate the utility of F-fludeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) for the diagnosis of VKH syndrome with AITD and to perform a literature review on the association between the 2 diseases.

Patient Concerns: A 55-year-old woman without the history of ocular trauma suffered from chronic headache. Read More

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http://dx.doi.org/10.1097/MD.0000000000010047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851737PMC
March 2018
19 Reads

HLA-DRB1*04:05 in two cases of Vogt-Koyanagi-Harada disease-like uveitis developing from an advanced melanoma patient treated by sequential administration of nivolumab and dabrafenib/trametinib therapy.

J Dermatol 2018 Jun 27;45(6):735-737. Epub 2018 Feb 27.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Although uveitis is reported as a rare adverse event (AE) associated with dabrafenib/trametinib therapy or nivolumab, the occurrence of severe uveitis is extremely rare. We describe two cases of Vogt-Koyanagi-Harada (VKH)-like uveitis developing after the sequential administration of nivolumab and dabrafenib/trametinib therapy. Interestingly, both cases had HLA-DRB1*04:05, which is strongly associated with VKH disease, and achieved biologically complete remission after the treatment for uveitis. Read More

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http://dx.doi.org/10.1111/1346-8138.14273DOI Listing
June 2018
4 Reads

MR findings of the orbit in patients with Vogt-Koyanagi-Harada disease.

Neuroradiology 2018 Apr 23;60(4):421-426. Epub 2018 Feb 23.

Department of Radiology, Gifu University School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.

Purpose: We aimed to evaluate the MR findings of the orbit in patients with Vogt-Koyanagi-Harada disease (VKHD).

Methods: We included 14 patients with clinically diagnosed VKHD, who underwent orbital MR imaging before treatment between May 2011 and August 2017. The mean duration from initial symptom onset to MR imaging was 16 days (range, 2-36 days). Read More

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http://dx.doi.org/10.1007/s00234-018-1999-zDOI Listing
April 2018
9 Reads

Association of human leukocyte antigen (HLA)-DQ and HLA-DQA1/DQB1 alleles with Vogt-Koyanagi-Harada disease: A systematic review and meta-analysis.

Medicine (Baltimore) 2018 Feb;97(7):e9914

Department of Ophthalmology, the First Affiliated Hospital of Jinan University.

Objective: The aim of this study was to evaluate the association of human leukocyte antigen (HLA)-DQ and HLA-DQA1/DQB1 alleles with Vogt-Koyanagi-Harada (VKH), providing further evidences on the genetic background of this disease.

Methods: A comprehensive literature search was conducted on the relationship of HLA-DQ and/or HLA-DQA1/DQB1 alleles with VKH through PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, VIP, and databases for grey literature. The last search was in October 2017. Read More

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http://dx.doi.org/10.1097/MD.0000000000009914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839848PMC
February 2018
5 Reads

How To Deal With Uveitis Patients?

Authors:
P Yang L Du Z Ye

Curr Mol Med 2018 03;17(7):468-470

The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, Chongqing Eye Institute, Chongqing, China.

During the past nine years, our center has grown into the largest uveitis referral center in China. To deal with this increasing stream of patients we have developed a management system to coordinate communication with our patients, their referring ophthalmologists, consultations with other medical specialties and worldrenowned foreign uveitis specialists. We have established the biggest database of uveitis patients records allowing continuous analysis of clinical features and response to treatment of patients with various uveitis entities as well as the evaluation of the relevance of various ancillary tests performed in this patient group. Read More

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http://dx.doi.org/10.2174/1566524018666180207153342DOI Listing
March 2018
3 Reads

Acquired myopia in Vogt-Koyanagi-Harada disease.

Int Ophthalmol 2019 Mar 3;39(3):521-531. Epub 2018 Feb 3.

Department of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.

Purpose: To analyze the change in refractive error and the axial length of chronic Vogt-Koyanagi-Harada (VKH) disease.

Methods: Medical records of 106 eyes of 54 adult VKH patients were analyzed. The refractive error and the axial length were compared between the baseline (defined as the time point at least 2 weeks after acute stage of VKH) and the final visit. Read More

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http://dx.doi.org/10.1007/s10792-018-0841-2DOI Listing
March 2019
3 Reads

Diagnostic Function of 3D Optical Coherence Tomography Images in Diagnosis of Vogt-Koyanagi-Harada Disease at Acute Uveitis Stage.

Med Sci Monit 2018 Feb 3;24:687-697. Epub 2018 Feb 3.

Department of Ophthalmology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China (mainland).

BACKGROUND This study analyzed the macular 3D-OCT images of Vogt-Koyanagi-Harada disease (VKH) in uveitis, explored the characteristics of 3D-OCT images of the macular region of VKH, and assessed which characteristics contribute most to VKH diagnosis. MATERIAL AND METHODS The 3D-OCT examination of 25 cases of VKH was performed on the macular area, and the image characteristics were analyzed. RESULTS Our study included a total of 50 eyes from 25 cases of VKH patients, 10 males and 15 females, aged 17 to 64 years, mean (39. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807914PMC
February 2018
7 Reads

Changes in Central Macular Thickness and Retinal Nerve Fiber Layer Thickness in Eyes with Vogt-Koyanagi-Harada Disease: A 2-Year Follow-Up Study.

Ophthalmologica 2018 16;239(2-3):143-150. Epub 2018 Jan 16.

Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Republic of Korea.

Purpose: To investigate the central macular thickness (CMT) and retinal nerve fiber layer (RNFL) thickness in eyes with Vogt-Koyanagi-Harada (VKH) disease associated with optic disc swelling and serous retinal detachment through a 24-month follow-up period.

Methods: We prospectively investigated 28 eyes of 14 treatment-naïve patients with acute VKH disease associated with optic disc swelling and serous retinal detachment and 30 eyes of 15 normal individuals to compare changes in the CMT and average RNFL thickness.

Results: The CMT was significantly lower in the eyes of the VKH group at 12 and 24 months. Read More

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https://www.karger.com/Article/FullText/481863
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http://dx.doi.org/10.1159/000481863DOI Listing
April 2018
7 Reads

Longitudinal observation of subretinal fibrosis in Vogt-Koyanagi-Harada disease.

BMC Ophthalmol 2018 Jan 15;18(1). Epub 2018 Jan 15.

Ophthalmology Department, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, 1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing, 100730, China.

Background: Subretinal fibrosis (SRF) is a vision-threatening complication of Vogt-Koyanagi-Harada disease (VKH). It has long been recognized as a sequela of chronic inflammation. The developmental process of SRF, however, has not been described. Read More

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http://dx.doi.org/10.1186/s12886-018-0670-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769357PMC
January 2018
6 Reads

Vogt-Koyanagi-Harada Disease Associated with Influenza A Virus Infection.

Intern Med 2018 Jun 11;57(11):1661-1665. Epub 2018 Jan 11.

Division of General Medicine, Department of Comprehensive Medicine 1, Saitama Medical Center, Jichi Medical University, Japan.

We herein report a case of a 31-year-old Japanese man who simultaneously had a positive influenza A virus antigen test result and Vogt-Koyanagi-Harada disease (VKHD), demonstrated by both diffuse multiple early hyperfluorescent points on fluorescein fundus photography and serous retinal detachments on optical coherence tomography. He had meningitis. It was difficult to determine whether the main cause of meningitis was influenza A or VKHD. Read More

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http://dx.doi.org/10.2169/internalmedicine.9819-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028674PMC
June 2018
3 Reads
0.970 Impact Factor

Associations between , and and Behçet's disease but not VKH syndrome in Han Chinese.

Oncotarget 2017 Dec 23;8(62):105037-105046. Epub 2017 Oct 23.

The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, China.

The present study was designed to explore the interrelationship between single nucleotide polymorphisms (SNP) of the tumor necrosis factor superfamily (TNFSF) and its respective receptor superfamily (TNFRSF) genes and Behcet's disease (BD) and Vogt-Koyanagi-Harada syndrome (VKH) in Han Chinese. The study sample included 796 patients with BD, 792 patients with VKH syndrome, and 1604 healthy controls. The genotyping of 35 SNPs was performed by MassARRAY platform (Sequenom), iPLEX Gold Assay, PCR-restriction fragment length polymorphism assay and TaqMan SNP assay. Read More

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http://dx.doi.org/10.18632/oncotarget.22064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739618PMC
December 2017
12 Reads

Recovery of macular cone photoreceptors in Vogt-Koyanagi-Harada disease.

Graefes Arch Clin Exp Ophthalmol 2018 Feb 20;256(2):387-394. Epub 2017 Dec 20.

Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.

Purpose: Our purpose was to study changes in macular cone photoreceptors in Vogt-Koyanagi-Harada (VKH) disease patients after high-dose corticosteroid treatment using an adaptive optics (AO) fundus camera.

Methods: We retrospectively analyzed 16 eyes of eight patients with new-onset acute VKH disease that were studied retrospectively. After serous retinal detachment (SRD) had resolved, AO images were obtained using the rtx1™ AO fundus camera over a 12-month course. Read More

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http://dx.doi.org/10.1007/s00417-017-3869-5DOI Listing
February 2018
7 Reads

Corticotherapy vs. Corticotherapy Plus Immunosuppressive Therapy in Acute Vogt-Koyanagi-Harada Disease.

Arch Soc Esp Oftalmol 2018 May 16;93(5):225-230. Epub 2017 Dec 16.

Asociación Para Evitar la Ceguera en México, Hospital Luis Sánchez Bulnes, Ciudad de México, México.

Introduction: Vogt-Koyanagi-Harada disease is a multisystem disorder characterized by a bilateral granulomatous panuveitis. Multiple therapeutic regimens have been used to control inflammation in acute uveitic stage to prevent irreversible visual loss. The purpose of this paper is to compare the effect, on functional and anatomic outcomes, of early treatment with standard corticotherapy vs. Read More

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http://dx.doi.org/10.1016/j.oftal.2017.09.010DOI Listing
May 2018
6 Reads

Association between CD40 rs1883832 and immune-related diseases susceptibility: A meta-analysis.

Oncotarget 2017 Nov 28;8(60):102235-102243. Epub 2017 Jun 28.

Department of Urology Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, 361003, China.

Background/objective: It has been reported that CD40 rs1883832 might be associated with immune-related diseases susceptibility. Owing to mixed and inconclusive results, we conducted a meta-analysis of case-control studies to summarize and clarify this association.

Methods/main Results: A systematic search of studies on the association between CD40 rs1883832 and immune-related diseases susceptibility was conducted in databases. Read More

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http://dx.doi.org/10.18632/oncotarget.18704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731949PMC
November 2017
6 Reads

Current and Newly Emerging Autoimmune Diseases.

Vet Clin North Am Small Anim Pract 2018 Mar 14;48(2):323-338. Epub 2017 Dec 14.

Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, Vet Med 3A, Davis, CA 95616, USA. Electronic address:

There are many autoimmune diseases that are recognized in domestic animals. The descriptions of diseases provide examples of the magnitude of immune targets and the variable nature of autoimmune diseases. Other autoimmune diseases that are recognized in dogs, cats, and horses include immune-mediated thrombocytopenia, VKH (Vogt-Koyanagi-Harada) ocular disease (dogs), and Evans syndrome (which includes both immune-mediated anemia and immune-mediated thrombocytopenia). Read More

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http://dx.doi.org/10.1016/j.cvsm.2017.10.010DOI Listing
March 2018
10 Reads

Multispectral image analysis in Vogt-Koyanagi-Harada disease.

Acta Ophthalmol 2018 Jun 8;96(4):411-419. Epub 2017 Dec 8.

The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, China.

Purpose: To investigate fundus abnormalities in Vogt-Koyanagi-Harada (VKH) disease by a noninvasive tool, multispectral imaging (MSI).

Methods: A total of 77 patients with VKH and 163 healthy controls were enrolled between January and April 2015. The MSI findings were evaluated in combination with fundus fluorescein angiography (FFA), optical coherent tomography (OCT) and fundus photography (FP). Read More

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http://dx.doi.org/10.1111/aos.13606DOI Listing
June 2018
13 Reads

Differences in photoreceptor recovery among patients and between different parts of the posterior pole in Vogt-Koyanagi-Harada disease.

Eye (Lond) 2018 03 17;32(3):572-578. Epub 2017 Nov 17.

Department of Ophthalmology, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

PurposeTo investigate the recovery of photoreceptors following the treatment in Vogt-Koyanagi-Harada (VKH) disease.Patients and methodsThis was a retrospective study. We enrolled 28 patients with VKH (56 eyes). Read More

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http://dx.doi.org/10.1038/eye.2017.250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848284PMC
March 2018
4 Reads

Treatment of Ipilimumab-Induced Vogt-Koyanagi-Harada Syndrome With Oral Dexamethasone.

Authors:
Matthew T Witmer

Ophthalmic Surg Lasers Imaging Retina 2017 11;48(11):928-931

The author presents a retrospective case report of a 54-year-old male with ipilimumab (Yervoy; Bristol-Myers Squibb, New York City, NY)-induced Vogt-Koyanagi-Harada Disease (VKH), which consisted of uveitis, optic neuritis, and choroiditis that was successfully treated with oral dexamethasone. The patient demonstrated resolution of uveitis, optic neuritis, and choroiditis 1 month following initiation of oral dexamethasone. Ipilimumab is a recently approved therapy for malignant melanoma. Read More

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http://dx.doi.org/10.3928/23258160-20171030-09DOI Listing
November 2017
9 Reads

Novel treatment regimen of Vogt-Koyanagi-Harada disease with a reduced dose of corticosteroids combined with immunosuppressive agents.

Curr Eye Res 2018 02 7;43(2):254-261. Epub 2017 Nov 7.

b University Eye Clinic Maastricht , Maastricht , The Netherlands.

Purpose: To investigate the effectiveness, visual outcome, and prognostic factors of Vogt-Koyanagi-Harada (VKH) disease treatment with a reduced dose of corticosteroids combined with immunosuppressive agents.

Methods: The clinical characteristics, auxiliary examinations, treatment result, visual outcome, and prognostic factors in VKH patients were analyzed.

Results: A total of 998 VKH patients were divided into posterior uveitis group (Group1), anterior uveal involvement group (Group 2), and recurrent granulomatous anterior uveitis group (Group 3). Read More

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http://dx.doi.org/10.1080/02713683.2017.1383444DOI Listing
February 2018
19 Reads

Evaluation of Vestibular Functions in Patients with Vogt-Koyanagi-Harada Disease.

Audiol Neurootol 2017 28;22(3):190-195. Epub 2017 Oct 28.

Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Vogt-Koyanagi-Harada (VKH) disease is an idiopathic, multisystem autoimmune disorder characterized by bilateral, diffuse granulomatous uveitis associated with neurological, audiovestibular, and dermatological manifestations. The purpose of this study is to investigate vestibular functions in patients with VKH disease. A total of 43 patients with VKH disease in Hokkaido University Hospital were enrolled in this study. Read More

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http://dx.doi.org/10.1159/000481426DOI Listing
July 2018
10 Reads