1,419 results match your criteria Vogt-Koyanagi-Harada Syndrome


Usefulness of intravitreal dexamethasone implant in the management of «Vogt-Koyanagi-Harada-like syndrome» secondary to map kinase pathway inhibition.

Arch Soc Esp Oftalmol 2020 Jun 24. Epub 2020 Jun 24.

Hospital Campo Aarañuelo, Navalmoral de la Mata, Cáceres, España.

The case is presented of a 58-year-old woman with a personal history of metastatic melanoma under treatment with trametinib and dabrafenib, as well as a decrease in bilateral visual acuity. On examination, it was observed that she had an anterior uveitis, vitritis, serous retinal detachment, vasculitis and disc oedema in both eyes. She was diagnosed with a Vogt-Koyanagi-Harada-like syndrome secondary to MAP kinase pathway inhibition. Read More

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http://dx.doi.org/10.1016/j.oftal.2020.05.014DOI Listing

[Changes of retinal structure after systemic immunosuppressive treatment in eyes with Vogt-Koyanagi-Harada disease].

Zhonghua Yi Xue Za Zhi 2020 Jun;100(22):1725-1729

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing 100730, China.

To assess structural changes in retina after systemic immunosuppressive treatment in Vogt-Koyanagi-Harada (VKH) disease using spectral-domain optical coherence tomography (SD-OCT). The clinical data of 17 VKH cases (34 eyes) who consecutively attended the Beijing Tongren Hospital between December 2015 and December 2019 were retrospectively reviewed. All the patients had acute or subacute onset, and underwent high-dose systemic corticosteroid and/or immunosuppressive treatment, with a followed-up time of at least 6 months. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20200212-00265DOI Listing

Epidemiology of 2000 Chinese uveitis patients from Northeast China.

Br J Ophthalmol 2020 May 18. Epub 2020 May 18.

Ophthalmologic Center, The Second Hospital of Jilin University, Changchun, China

Aims: To study the clinical characteristics of 2000 patients with uveitis admitted to the ophthalmology centre of the Second Hospital of Jilin University.

Methods: We retrospectively analysed 2000 patients with uveitis who were admitted to the uveitis clinic of the Second Hospital of Jilin University from July 2010 to June 2019 and analysed data on sex, onset age, onset season, anatomical classification, visual acuity and compared the results with those of other investigation studies.

Results: Among 2000 uveitis patients, the mean age of onset was 39. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-316256DOI Listing
May 2020
2.976 Impact Factor

Serous Macular Detachment in Probable Vogt-Koyanagi-Harada Syndrome.

JAMA Ophthalmol 2020 May 14;138(5):e191981. Epub 2020 May 14.

Department of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California.

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http://dx.doi.org/10.1001/jamaophthalmol.2019.1981DOI Listing

Vogt-Koyanagi-Harada-like syndrome induced by immune checkpoint inhibitors in a melanoma patient.

Clin Exp Dermatol 2020 May 11. Epub 2020 May 11.

Department of Dermatology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.

Immune checkpoint inhibitors, such as anti-PD-1 and anti-CTLA-4 antibodies, have been widely used for treating metastatic melanoma. Here, we describe a case of Vogt-Koyanagi-Harada (VKH)-like syndrome in a melanoma patient during treatment with immune checkpoint inhibitors. Read More

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http://dx.doi.org/10.1111/ced.14282DOI Listing

Evolving spectrum of drug-induced uveitis at the era of immune checkpoint inhibitors results from the WHO's pharmacovigilance database.

J Autoimmun 2020 Jul 14;111:102454. Epub 2020 Apr 14.

Department of Internal Medicine and Clinical Immunlogy, Sorbonne Université, Pitié-Salpêtrière University Hospital, Paris, France; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Centre national de référence maladies auto-immunes systémiques rares, Centre national de référence maladies auto-inflammatoires et amylose, INSERM UMR_S 959, Immunologie-Immunopathologie-Immunothérapie, i3, France. Electronic address:

Purpose: Drug-induced uveitis is a rare but sight-threatening condition. We seek to determine the spectrum of drug-induced uveitis at the era of immune checkpoint inhibitors (ICI).

Methods: Retrospective pharmacovigilance study based on adverse drug reactions reported within VigiBase, the WHO international pharmacovigilance database. Read More

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http://dx.doi.org/10.1016/j.jaut.2020.102454DOI Listing

Concurrent presence of retinal hemorrhages in the setting of acute Vogt-Koyanagi-Harada syndrome - an unusual presentation.

J Ophthalmic Inflamm Infect 2020 Apr 15;10(1):12. Epub 2020 Apr 15.

Department of Ophthalmology and Visual Sciences, Khoo Teck Puat Hospital, Yishun, Singapore.

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http://dx.doi.org/10.1186/s12348-020-00203-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158964PMC

Comprehensive meta-analysis reveals an association of the HLA-DRB1*1602 allele with autoimmune diseases mediated predominantly by autoantibodies.

Autoimmun Rev 2020 Jun 29;19(6):102532. Epub 2020 Mar 29.

Priority Area Asthma & Allergy, Research Center Borstel, Airway Research Center North (ARCN), Members of the German Center for Lung Research (DZL), Borstel, Germany. Electronic address:

The human leukocytes antigen (HLA)-DRB1*16:02 allele has been suggested to be associated with many autoimmune diseases. However, a validation of the results of the different studies by a comprehensive analysis of the corresponding meta data is lacking. In this study, we performed a meta-analysis of the association between HLA-DRB1*16:02 allele with various autoimmune disorders. Read More

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http://dx.doi.org/10.1016/j.autrev.2020.102532DOI Listing

Bilateral serous retinal detachments associated with burkitt lymphoma.

Am J Ophthalmol Case Rep 2020 Jun 7;18:100654. Epub 2020 Mar 7.

Department of Ophthalmology & Visual Sciences, Montefiore Medical Center/AECOM, Bronx, NY, USA.

Purpose: To report a case of bilateral serous retinal detachments in a patient found to have burkitt lymphoma.

Observations: A patient who presented with bilateral serous retinal detachments and "B" symptoms underwent extensive workup and was found to have burkitt lymphoma. Multiagent chemotherapy was initiated with resolution of the serous retinal detachments and visual recovery occurring in parallel to disease remission. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078497PMC

Adalimumab effectively controls both anterior and posterior noninfectious uveitis associated with systemic inflammatory diseases: focus on Behçet's syndrome.

Inflammopharmacology 2020 Jun 10;28(3):711-718. Epub 2020 Mar 10.

Department of Experimental and Clinical Medicine, University of Firenze, 50134, Florence, Italy.

Background: To compare the efficacy of Adalimumab (ADA) in noninfectious anterior uveitis (AU) and posterior segment (PS) involvement, associated with different conditions, with a focus on Behçet's syndrome (BS).

Methods: In this retrospective, multicenter post-hoc study, we evaluated the efficacy of ADA in terms of ocular control and relapses in 96 patients with AU and PS uveitis, either idiopathic (IU) or associated with BS or with other systemic disorders (OSD) (Juvenile Idiopathic Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, Vogt-Koyanagi-Harada, Inflammatory Bowel Disease), followed in three tertiary referral centers.

Results: Ninety-six patients (45 AU; 51 PS uveitis) were included. Read More

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http://dx.doi.org/10.1007/s10787-020-00697-4DOI Listing

Management of recalcitrant vitiligo in Vogt-Koyanagi-Harada syndrome: Adjuvant ablative fractional laser.

Pediatr Dermatol 2020 May 4;37(3):514-516. Epub 2020 Mar 4.

Dermatology Department, Gülhane School of Medicine, Health Sciences University, Ankara, Turkey.

The course of dermatologic findings in Vogt-Koyanagi-Harada disease is variable. Herein, we report the remarkable repigmentation of widespread facial vitiligo lesions in an adolescent girl with Vogt-Koyanagi-Harada disease. The patient was treated with a combination of fractional erbium:YAG laser, topical tacrolimus, and phototherapy. Read More

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http://dx.doi.org/10.1111/pde.14108DOI Listing

Unilateral Presentation of Vogt-Koyanagi-Harada Syndrome.

J Ophthalmic Vis Res 2020 Jan-Mar;15(1):99-103. Epub 2020 Feb 2.

Eye Research Center, Matini Eye Hospital, Kashan University of Medical Sciences, Kashan, Iran.

Purpose: To report a case of acute Vogt-Koyanagi-Harada (VKH) disease with unilateral clinical manifestations followed by late fellow eye involvement.

Case Report: This case report reviews the 12-month follow-up observation of a 44-year old woman who presented to the emergency department with unilateral progressive and painless visual blurring. Ophthalmoscopic findings, best-corrected visual acuity (BCVA), fluorescein angiography (FAG), enhanced-depth optical coherence tomography (EDI-OCT), indocyanine green angiography, and response to treatment were evaluated. Read More

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http://dx.doi.org/10.18502/jovr.v15i1.5954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001015PMC
February 2020

Vogt-Koyanagi-Harada (VKH) syndrome: A new perspective for healthcare professionals.

J Family Med Prim Care 2020 Jan 28;9(1):31-35. Epub 2020 Jan 28.

Private Practitioner, New Delhi, India.

Vogt-Koyanagi-Harada syndrome (VKH syndrome) is a rare granulomatous inflammatory disease that affects the melanin pigment producing melanocytes and mainly affects the pigmented structures such as eyes, ear, skin, meninges, and hair. VKT is an autoimmune disorder, which is mainly a T CD4+ Th1 lymphocyte-mediated aggression to melanocytes, in individuals with a genetic predisposition, in particular, the presence of HLA-DRB1 * 0405 allele. Melanin usually gives color to skin, hair, and eyes. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_787_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014871PMC
January 2020

Vogt-Koyanagi-Harada Syndrome: A Rare Cause of Panuveitis Presenting as Unilateral Loss of Visual Acuity.

J Clin Rheumatol 2020 Feb 22. Epub 2020 Feb 22.

From the Division of Rheumatology, Department of Medicine, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN; and Vanderbilt Eye Institute, Nashville, TN.

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http://dx.doi.org/10.1097/RHU.0000000000001351DOI Listing
February 2020

Ocular syphilis mimicking Vogt-Koyanagi-Harada disease.

Taiwan J Ophthalmol 2019 Oct-Dec;9(4):271-275. Epub 2019 Dec 13.

Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.

The study aimed to present a case of ocular syphilis mimicking Vogt-Koyanagi-Harada (VKH) disease. This is an observational case report. A 59-year-old female with Sicca syndrome and rheumatoid arthritis presented to the ophthalmologic department with blurred vision of the right eye for 5 days accompanied by color sensation loss in both eyes. Read More

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http://dx.doi.org/10.4103/tjo.tjo_63_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947747PMC
December 2019

Vogt-Koyanagi-Harada syndrome: importance of early treatment.

Acta Neurol Belg 2020 Jan 11. Epub 2020 Jan 11.

Department of Neurology, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, Referral Centre of the Ministry of Health of the Republic of Croatia for Epilepsy, Affiliated to EpiCARE ERN, Kispaticeva 12, 10000, Zagreb, Croatia.

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http://dx.doi.org/10.1007/s13760-020-01273-xDOI Listing
January 2020

Bilateral retinal detachments presenting as manifestations of Vogt-Koyanagi-Harada syndrome.

Eur J Rheumatol 2020 Jan 2:1-2. Epub 2020 Jan 2.

Department of Ophthalmology and Visual Science, University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.5152/eurjrheum.2019.19032DOI Listing
January 2020

Evaluation of Retinal Pigment Epithelium Layer Change in Vogt-Koyanagi-Harada Disease With Multicontrast Optical Coherence Tomography.

Invest Ophthalmol Vis Sci 2019 08;60(10):3352-3362

Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan.

Purpose: Clinical evaluation of retinal pigment epithelium (RPE) change is important for the therapeutic management of chronic Vogt-Koyanagi-Harada (VKH) disease. We evaluated long-term change in the RPE layer in VKH disease, using near-infrared (NIR; 817 nm) images and autofluorescence images at 488 nm (short-wavelength [SW]-AF) and 785 nm (NIR-AF), and compared those images with images from multicontrast optical coherence tomography (MC-OCT). MC-OCT is capable of simultaneous measurement of OCT angiography, polarization-sensitive OCT, and standard OCT. Read More

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http://dx.doi.org/10.1167/iovs.19-27378DOI Listing

rs4750316 is associated with Vogt-Koyanagi-Harada syndrome in a Han Chinese population.

Mol Vis 2019 2;25:834-842. Epub 2019 Dec 2.

Laboratory Animal Center, Chongqing Medical University, Yixueyuan Road 1, Yuzhong District, Chongqing, P. R. China.

Purpose: The and genes are said to be associated with multiple autoimmune diseases. This study investigated the association between these genes and VogtKoyanagiHarada (VKH) syndrome in Han Chinese.

Methods: A two-stage case-control study was performed on three single nucleotide polymorphisms ([SNPs] rs4750316, rs11258747, and rs947474) of the gene and three SNPs (rs842647, rs702873, and rs13031237) of the gene using PCR-restriction fragment length polymorphism (PCR-RFLPs) in a total of 859 patients with VKH syndrome and 1,542 healthy controls. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925663PMC

Unique clinical spectrum with distinguishing diagnostic features in Vogt-Koyanagi-Harada syndrome.

BMJ Case Rep 2019 Dec 29;12(12). Epub 2019 Dec 29.

Ophthalmology, King Saud University, Riyadh, Saudi Arabia.

A 36-year-old ulcerative colitis male patient on treatment for 7 years was referred to dermatology with resistant alopecia universalis and hypopigmented patches on limbs for 5 months. During this time he also reported to ophthalmology with acute bilateral decreased vision for 5 days. His examination revealed hyperaemic discs, multifocal retinal detachments and choroidal granulomas. Read More

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http://dx.doi.org/10.1136/bcr-2019-231397DOI Listing
December 2019

Aqueous cytokine levels in four common uveitis entities.

Int Immunopharmacol 2020 Jan 24;78:106021. Epub 2019 Nov 24.

The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, PR China. Electronic address:

To investigate aqueous cytokine profiles in acute anterior uveitis (AAU), Fuchs' syndrome, Vogt-Koyanagi-Harada (VKH) disease and Behcet's disease (BD), we assayed the concentrations of 17 cytokines by multiplex immunoassay in aqueous humor (AqH) collected during cataract surgery from 24 AAU, 29 Fuchs' syndrome, 29 VKH disease, 30 BD and 30 senile cataract control patients. Aqueous cytokine levels were compared between the five groups and analysed by logistic regression. Cytokine levels were then compared between uveitis patients who underwent cataract surgery within 3 months and those who underwent this surgery more than 3 months after complete control of intraocular inflammation. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.106021DOI Listing
January 2020

Replication of Genome-Wide Association Analysis Identifies New Susceptibility Loci at Long Noncoding RNA Regions for Vogt-Koyanagi-Harada Disease.

Invest Ophthalmol Vis Sci 2019 11;60(14):4820-4829

The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, and Chongqing Eye Institute, Chongqing, The People's Republic of China.

Purpose: This study was aimed at investigating the association of long noncoding RNA (lncRNA)-related single nucleotide polymorphisms (SNPs) with Vogt-Koyanagi-Harada (VKH) disease.

Methods: LncRNA-related SNPs were selected by multi-omics analysis. Genotyping, expression of lncRNA and mRNA, cell proliferation, and cytokine production were tested by MassARRAY System, real-time PCR, CCK8, and ELISA. Read More

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http://dx.doi.org/10.1167/iovs.19-27708DOI Listing
November 2019
3.404 Impact Factor

Correlation between visual acuity and human leukocyte antigen DRB1*04 in patients with Vogt-Koyanagi-Harada disease.

BMC Ophthalmol 2019 Nov 7;19(1):214. Epub 2019 Nov 7.

Department of Ophthalmology and Visual Science, Graduate School of Medicine, Osaka City University, 1-5-7 Asahimachi, Abeno-ku, Osaka-shi, 545-8586, Japan.

Background: The common presence of human leukocyte antigen (HLA)-DRB1*04 in Vogt-Koyanagi-Harada (VKH) disease is well known. The aim of this study was to investigate the relationship between visual prognosis and HLA-DRB1*04 alleles during systemic corticosteroid therapy in patients with VKH disease.

Methods: This retrospective case series included 57 eyes from 29 consecutive patients with treatment-naïve VKH disease who received systemic corticosteroid therapy. Read More

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http://dx.doi.org/10.1186/s12886-019-1227-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836542PMC
November 2019

Impact of Inflammation and Treatment on Self-reported Quality of Life in Patients with Non-acute Vogt-Koyanagi-Harada Disease (VKHD).

Ocul Immunol Inflamm 2019 Oct 31:1-12. Epub 2019 Oct 31.

Department of Ophthalmology, LIM-33, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.

: To evaluate associations between vision-related (VR-) and health-related (HR-) QoL metrics and inflammation and treatment in non-acute VKHD patients.: Cross-sectional study in a tertiary center in Sao Paulo, Brazil with 22 patients with non-acute VKHD followed prospectively for ≥12 months since acute disease onset, with systematic evaluation and predefined treatment protocols. VR- and HR-QoL aspects were assessed by VFQ-25 and SF-36 questionnaires, respectively. Read More

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http://dx.doi.org/10.1080/09273948.2019.1668431DOI Listing
October 2019

[Systemic biological treatment in ophthalmology].

Orv Hetil 2019 Nov;160(44):1744-1750

Szemészeti Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Üllői út 26., 1085.

We present herewith cases of non-infectious uveitis with biological treatment where the ocular complaints were the initial symptoms indicating a multi-organ autoimmune disease. The first case was a patient with panuveitis and Vogt-Koyanagi-Harada disease, the second case was also a panuveitic patient with sarcoidosis and the third case was a patient with intermediate uveitis and inflammatory bowel disease. In all cases, emerging new, biological therapy (adalimumab) was necessary to achieve permanent inactive period of uveitis and the autoimmune disease. Read More

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http://dx.doi.org/10.1556/650.2019.31552DOI Listing
November 2019

Vogt-Koyanagi-Harada Syndrome in a Ugandan: Diagnostic and Therapeutic Challenges.

Case Rep Med 2019 16;2019:5192754. Epub 2019 Sep 16.

Department of Internal Medicine, College of Health Sciences, Makerere University, P. O. Box 7072, Kampala, Uganda.

Background: Vogt-Koyanagi-Harada (VKH) syndrome is a multisystemic autoimmune disease of uncertain pathogenesis. Infectious aetiology has been proposed which is suggested to lead to the loss of melanocytes in the skin, inner ear, meninges, and uvea in those who are genetically predisposed. Information regarding VKH syndrome is scanty among the African population. Read More

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http://dx.doi.org/10.1155/2019/5192754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766141PMC
September 2019
1 Read

Textural Properties of Choriocapillaris on OCTA in Healed Inflammatory Choriocapillaropathies.

Ophthalmic Surg Lasers Imaging Retina 2019 09;50(9):566-572

Background And Objective: To evaluate the flow characteristics and textural properties of choriocapillaris (CC) on optical coherence tomography angiography in eyes with resolved inflammatory choriocapillaropathies and Vogt-Koyanagi-Harada (VKH) disease.

Patients And Methods: A cohort of eyes with healed acute posterior multifocal placoid pigment epitheliopathy (APMPPE), serpiginous choroiditis (SC), and VKH disease were included. A 3 mm × 3 mm OCT angiogram of CC was acquired and graded for flow characteristics and textural properties. Read More

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https://www.healio.com/doiresolver?doi=10.3928/23258160-2019
Publisher Site
http://dx.doi.org/10.3928/23258160-20190905-05DOI Listing
September 2019
3 Reads

Case Report of a 4-Year-Old Child with Complicated Vogt-Koyanagi-Harada at a Tertiary Eye Hospital.

Middle East Afr J Ophthalmol 2019 Apr-Jun;26(2):117-119. Epub 2019 Aug 26.

Department of Pediatric Ophthalmology, King Khalid Eye Specialist Hospital, Riyadh, Saudi Arabia.

Vogt-Koyanagi-Harada (VKH) disease is a chronic, bilateral, granulomatous panuveitis associated with cutaneous, neurologic, and auditory manifestations. We report a 4-year-old Saudi boy who developed severe ocular complications by 5 years of age. He presented to King Khalid Eye Specialist Hospital at the age of 4 years and was previously operated on elsewhere for cataract with intraocular lens implantation in his right eye at the age of 3 years. Read More

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http://dx.doi.org/10.4103/meajo.MEAJO_244_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737783PMC
November 2019
2 Reads

Presumed atypical peripapillary Vogt-Koyanagi-Harada disease.

Am J Ophthalmol Case Rep 2019 Dec 27;16:100548. Epub 2019 Aug 27.

University of Sao Paulo Hospital of Clinics - Universidade de São Paulo, Av. Dr. Enéas Carvalho de Aguiar, 255, São Paulo, SP, Brazil.

Purpose: To describe a case of bilateral presumed atypical Harada disease with sequential, not simultaneous, involvement of the peripapillary retina (subretinal fluid) in a healthy patient with no systemic complaints.

Observation: A 35-year-old healthy white man presented with sudden paracentral visual loss in the left eye. His medical history was unremarkable. Read More

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http://dx.doi.org/10.1016/j.ajoc.2019.100548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737331PMC
December 2019
3 Reads

Optical coherence tomography diagnostic signs in posterior uveitis.

Prog Retin Eye Res 2020 03 9;75:100797. Epub 2019 Sep 9.

Department of Ophthalmology, Inselspital, Bern University Hospital and University of Bern, Switzerland; BPRC, Bern Photographic Reading Center, University of Bern, Switzerland; Feinberg School of Medicine, Northwestern University Chicago, Chicago, IL, USA.

A diagnostic sign refers to a quantifiable biological parameter that is measured and evaluated as an indicator of normal biological, pathogenic, or pharmacologic responses to a therapeutic intervention. When used in translational research discussions, the term itself often alludes to a sign used to accelerate or aid in diagnosis or monitoring and provide insight into "personalized" medicine. Many new diagnostic signs are being developed that involve imaging technology. Read More

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http://dx.doi.org/10.1016/j.preteyeres.2019.100797DOI Listing
March 2020
2 Reads

Lymphocyte proliferation induced by high-affinity peptides for HLA-B*51:01 in Behçet's uveitis.

PLoS One 2019 12;14(9):e0222384. Epub 2019 Sep 12.

Department of Pharmacology, University of Shizuoka, Shizuoka, Japan.

Several proteins have been proposed as candidate auto-antigens in the pathogenesis of Behçet's disease (BD). In this study, we aimed to confirm the cellular responses to candidate peptide autoantigens with high affinity for the HLA-B*51:01 molecule using computerized binding predictions and molecular dynamics simulations. We identified two new candidate peptides (HSP65PD, derived from heat shock protein-65, and B51PD, derived from HLA-B*51:01) with high-affinity to the HLA-B*51:01 binding pocket using the Immune Epitope Database for Major Histocompatibility Complex-I Binding Prediction and molecular dynamics simulations. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0222384PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742369PMC
March 2020
2 Reads

Full-field electroretinogram behavior in Vogt-Koyanagi-Harada disease: a 24-month longitudinal study in patients from acute onset evaluated with multimodal analysis.

Graefes Arch Clin Exp Ophthalmol 2019 Oct 22;257(10):2285-2295. Epub 2019 Aug 22.

Department of Ophthalmology, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.

Purpose: To prospectively evaluate the dynamic changes of the full-field electroretinogram (ff-ERG) and its association with inflammatory signs in patients with Vogt-Koyanagi-Harada disease (VKHD) followed up after acute onset.

Methods: Twelve acute VKHD patients, who were followed up for at least 24 months, were enrolled at a tertiary center from June 2011 to January 2017. Treatment consisted of intravenous methylprednisolone followed by 1 mg/kg/day of oral prednisone with a slow tapering associated with late non-steroidal immunosuppressive therapy in previously defined cases. Read More

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http://dx.doi.org/10.1007/s00417-019-04440-wDOI Listing
October 2019

Macular Abnormalities in Vogt-Koyanagi-Harada Disease.

Ocul Immunol Inflamm 2019 15;27(8):1195-1202. Epub 2019 Aug 15.

University Eye Clinic Maastricht, Maastricht, The Netherlands.

: To investigate the prevalence of macular abnormalities in Chinese Vogt-Koyanagi-Harada (VKH) patients.: Clinical characteristics, therapeutic effectiveness and visual outcome were reviewed and analyzed.: The most common macular abnormality was macular edema (ME), followed by macular choroidal neovascularization (CNV). Read More

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http://dx.doi.org/10.1080/09273948.2019.1624781DOI Listing

A case of probable Vogt-Koyanagi-Harada disease in a 3-year-old girl.

BMC Ophthalmol 2019 Aug 13;19(1):179. Epub 2019 Aug 13.

Division of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.

Background: Vogt-Koyanagi-Harada (VKH) disease is a T-cell-mediated autoimmune disorder characterized by bilateral granulomatous panuveitis with various systemic manifestations. Although VKH disease rarely occurs in the pediatric population, the clinical course tends to be aggressive, and the visual prognosis is worse than that in adult patients due to severe ocular complications secondary to recurrent inflammation.

Case Presentation: A 3-year-old girl with probable VKH was referred to Kobe University Hospital. Read More

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http://dx.doi.org/10.1186/s12886-019-1192-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693137PMC
August 2019
2 Reads

Anesthesia for a patient with Vogt-Koyanagi-Harada disease.

J Clin Anesth 2019 Dec 1;58:131. Epub 2019 Aug 1.

Department of Anesthesiology, Emory University Children's Pediatric Institute, Atlanta, USA.

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http://dx.doi.org/10.1016/j.jclinane.2019.07.004DOI Listing
December 2019

Teaching NeuroImages: A case of Vogt-Koyanagi-Harada disease with bilateral retinal detachment.

Neurology 2019 07;93(4):e421

From the Department of Neurology, University of Minnesota, Minneapolis.

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http://dx.doi.org/10.1212/WNL.0000000000007830DOI Listing
July 2019
1 Read

Autoimmune diseases affecting skin melanocytes in dogs, cats and horses: vitiligo and the uveodermatological syndrome: a comprehensive review.

BMC Vet Res 2019 Jul 19;15(1):251. Epub 2019 Jul 19.

Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.

Autoimmune dermatoses targeting melanocytes have gained attention in human medicine due to their progressive nature and the social impact suffered by affected individuals. In veterinary medicine, vitiligo and the uveodermatological syndrome are the two autoimmune diseases that are known to affect skin melanocytes.In the first part of this article, we will review the signalment, clinical signs, histopathology and the treatment outcome of vitiligo in dogs, cats and horses; where pertinent, we compare the animal diseases to their human homologue. Read More

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http://dx.doi.org/10.1186/s12917-019-2003-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639964PMC
July 2019
7 Reads

Glucocorticoid Receptor-α and MKP-1 as Candidate Biomarkers for Treatment Response and Disease Activity in Vogt-Koyanagi-Harada Disease.

Am J Ophthalmol 2019 11 16;207:319-325. Epub 2019 Jul 16.

Department of Ophthalmology, Faculty of Medicine, University of Chile, Santiago, Chile.

Purpose: To investigate the potential of utilizing the expression of genes for glucocorticoid receptor (GR) and mitogen-activated protein kinase phosphatase-1 (MKP-1) as biomarkers of corticosteroid (CS) refractoriness and disease activity in patients with Vogt-Koyanagi-Harada (VKH) disease.

Design: Prospective cohort study.

Methods: Twenty VKH patients receiving their first cycle of CS treatment in the absence of additional systemic immunosuppressive therapy and a control group of fifteen healthy volunteers were recruited from the University of Chile (Santiago, Chile) and US National Institutes of Health (Bethesda, United States). Read More

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http://dx.doi.org/10.1016/j.ajo.2019.06.032DOI Listing
November 2019
3 Reads

The effectiveness of adalimumab treatment for non-infectious uveitis.

Immunol Med 2019 Jun 17;42(2):79-83. Epub 2019 Jul 17.

Department of Ophthalmology, Kyushu University Graduate School of Medicine , Fukuoka , Japan.

Uveitis, which is a major cause of blindness worldwide, is defined as intraocular inflammation that affects the iris, ciliary body, vitreous, retina and choroid. Tumor necrosis factor-alpha (TNF-α) is a key cytokine involved in the pathogenesis of many inflammatory diseases including uveitis. Corticosteroids and immunosuppressive agents are the conventional therapy to treat non-infectious uveitis. Read More

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http://dx.doi.org/10.1080/25785826.2019.1642080DOI Listing

Ultrabiomicroscopic Findings in Acute Uveitic, Convalescent and Chronic Recurrent Stage of Vogt-Koyanagi-Harada Syndrome.

Ocul Immunol Inflamm 2020 May 17;28(4):626-631. Epub 2019 Jul 17.

Inflammatory Eye Disease Clinic, Asociación Para Evitar la Ceguera en México, Hospital Dr Luis Sánchez Bulnes , México City, México.

Purpose: To describe the ultrabiomicroscopy (UBM) characteristics in patients with uveitic, convalescent, and recurrent Vogt-Koyanagi-Harada (VKH) disease.

Methods: In this prospective, non-interventional, and observational study, all UBM variables, namely pars plicata and pars plana thickness, ciliochoroidal detachment, angle chamber, anterior chamber depth, ID2, and presence of ciliary processes, were compared between acute uveitic, convalescent, and chronic-recurrent phases.

Results: Ninety-one eyes were analyzed. Read More

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http://dx.doi.org/10.1080/09273948.2019.1609527DOI Listing
May 2020
4 Reads

Severe Cutaneous Adverse Reactions during Tapering of High-Dose Systemic Steroid Therapy for Autoimmune Diseases: Implications for Non-HIV Immune Reconstitution Inflammatory Syndrome.

Case Rep Dermatol 2019 May-Aug;11(2):166-174. Epub 2019 Jun 13.

Department of Dermatology, School of Medicine, Showa University, Tokyo, Japan.

We present 2 cases of severe cutaneous adverse reactions (SCARs) during the tapering of corticosteroids, following several courses of high-dose pulse therapy for Vogt-Koyanagi-Harada disease. Their general symptoms and mucous membrane lesions, including those of the eye, were milder than those usually seen in Stevens-Johnson syndrome/toxic epidermal necrolysis. Based on their initial presentation, these cases were not initially identified as SCARs, but continued to progress over the course of a few days. Read More

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http://dx.doi.org/10.1159/000500945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600039PMC
June 2019
11 Reads

Efficacy of Adalimumab for Chronic Vogt-Koyanagi-Harada Disease Refractory to Conventional Corticosteroids and Immunosuppressive Therapy and Complicated by Central Serous Chorioretinopathy.

Ocul Immunol Inflamm 2020 Apr 3;28(3):509-512. Epub 2019 Jul 3.

Department of Ophthalmology, National Defense Medical College, Tokorozawa, Japan.

: To report the efficacy of adalimumab in a case of chronic Vogt-Koyanagi-Harada (VKH) disease refractory to conventional corticosteroids and immunosuppressive therapy and complicated by central serous chorioretinopathy (CSC).: A 66-year-old woman diagnosed with VKH was treated with intravenous corticosteroids followed by oral corticosteroids and cyclosporine. However, systemic corticosteroids could not be tapered because of recurrent ocular inflammation and systemic complications (diabetes mellitus, moon face, bone weakness), while CSC appeared in both eyes. Read More

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http://dx.doi.org/10.1080/09273948.2019.1603312DOI Listing
April 2020
1 Read

Commentary: Appraisal of histopathological correlations in Vogt-Koyanagi-Harada uveitis.

Indian J Ophthalmol 2019 07;67(7):1219-1221

Uveitis Services, Aravind Eye Hospital, Puducherry, India.

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http://dx.doi.org/10.4103/ijo.IJO_409_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611315PMC
July 2019
2 Reads

Clinicopathological and immunohistochemistry correlation in a case of Vogt-Koyanagi-Harada disease.

Indian J Ophthalmol 2019 07;67(7):1217-1219

Department of Uveitis and Ocular Pathology, Medical Research Foundation, Sankara Nethralaya, Chennai, India.

Vogt-Koyanagi-Harada (VKH) disease is a systemic disorder causing bilateral panuveitis. Histopathological documentation along with molecular diagnostic evidence in VKH eye is a rarity. We present a 46-year-old woman with VKH with several ocular complications and subsequently enucleation of the right eye was done because of painful blind eye. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1800_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611308PMC
July 2019
2 Reads
0.927 Impact Factor

Bilateral Cochlear Implantation in Vogt-Koyanagi-Harada Syndrome: A Case Report.

Otol Neurotol 2019 08;40(7):e694-e697

Department of Otolaryngology, Neurotology & Skull Base Surgery, King Saud University, Riyadh, Saudi Arabia.

Objective: To evaluate cochlear implantation in Vogt-Koyanagi-Harada syndrome with regard to surgical difficulties and hearing outcomes.

Patients: Single case report.

Intervention(s): Therapeutic complete electrode insertion during surgery despite evident intra-cochlear fibrosis. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002262DOI Listing
August 2019
9 Reads

Development of Acute Vogt-Koyanagi-Harada-like Syndrome during the Treatment Course with Vemurafenib for Metastatic Melanoma.

Ocul Immunol Inflamm 2020 Apr 4;28(3):505-508. Epub 2019 Jun 4.

Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

: To report on ocular Vogt-Koyanagi-Harada (VKH)-like syndrome under vemurafenib treatment for metastatic melanoma.: A case report.: Description of clinical and imaging manifestations including fundus photography, fluorescein, and indocyanine green angiography. Read More

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http://dx.doi.org/10.1080/09273948.2019.1597896DOI Listing
April 2020
11 Reads

Self-Reported Quality of Life in Patients with Long-Standing Vogt-Koyanagi-Harada Disease.

Ocul Immunol Inflamm 2020 Apr 28;28(3):409-420. Epub 2019 May 28.

Department of Ophthalmology, LIM-33, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

: To assess health-related (HR-) and vision-related (VR-) quality of life (QoL) in patients with long-standing Vogt-Koyanagi-Harada disease (VKHD).: Cross-sectional study of 49 patients with disease duration ≥12 months followed at Uveitis Service, Universidade de São Paulo, BR, for at least 12 months. HR- and VR-QoL were evaluated using SF-36 and NEI VFQ-25 questionnaires, respectively. Read More

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http://dx.doi.org/10.1080/09273948.2019.1595672DOI Listing
April 2020
5 Reads

Vogt-Koyanagi-Harada Syndrome in Brazilian Children.

Ocul Immunol Inflamm 2020 Apr 23;28(3):402-408. Epub 2019 May 23.

Department of Ophthalmology and Visual Sciences, Paulista School of Medicine, Federal University of São Paulo, UNIFESP, Sao Paulo, Brazil.

To evaluate the characteristics of Vogt-Koyanagi-Harada (VKH) syndrome in Brazilian children.M Clinical data were obtained from the medical records of six children with VKH disease from March 2014 to June 2018 at the Federal University of São Paulo, Brazil. Six patients met the diagnostic criteria for VKH. Read More

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http://dx.doi.org/10.1080/09273948.2019.1588982DOI Listing
April 2020
6 Reads

Vogt-Koyanagi-Harada syndrome presenting with bilateral optic disc swelling and leptomeningeal enhancement.

BMJ Case Rep 2019 May 21;12(5). Epub 2019 May 21.

Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, South Australia, Australia.

Vogt-Koynagi-Harada (VKH) disease is a clinical syndrome with classical ocular and extraocular findings that is not uncommonly described in Asian, Middle-Eastern and South American populations. We describe a case of VKH in an elderly Polish-Australian distinguished by prominent bilateral disc swelling rather than uveitis and marked leptomeningeal enhancement on MRI which led to extensive investigation including brain biopsy. Both disc oedema and MRI abnormalities improved dramatically with systemic steroid therapy. Read More

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http://dx.doi.org/10.1136/bcr-2019-229719DOI Listing
May 2019
7 Reads

Tattoo granulomas with uveitis rather than Vogt-Koyanagi-Harada disease after tattooing?

Authors:
Nicolas Kluger

Can J Ophthalmol 2019 06 15;54(3):401. Epub 2019 Jan 15.

Department of Dermatology, Allergology and Venereology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland; Tattoo Consultation, Department of Dermatology, Bichat-Claude Bernard Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.jcjo.2018.10.020DOI Listing
June 2019
1 Read