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    1270 results match your criteria Vogt-Koyanagi-Harada Syndrome

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    Did poor eyesight influence Goya's late works? Medicine and art history in search for an interpretation of Goya's late paintings.
    Acta Ophthalmol 2018 Apr 15. Epub 2018 Apr 15.
    Official School of Languages n.1, Zaragoza, Spain.
    Purpose: The aim of this article is to 'determine' the scope of Goya's eyesight difficulties and assess the extent to which those difficulties might explain his style of painting in the last years of his life.

    Methods: We analyse the correspondence and late works of the Aragonese painter Francisco de Goya y Lucientes (1746-1828), who has been admired for his use of colour, his energetic loose brushstrokes, his disregard for details and his bold compositions, as well as for his different artistic styles throughout his life.

    Results: The evolution of Goya's style of painting in his later works seems to have been the consequence of an eyesight condition, probably age-related cataracts at an advanced stage. Read More

    A Case of Vogt-Koyanagi-Harada Syndrome Mimicking Optic Neuritis.
    J Coll Physicians Surg Pak 2018 Apr;28(4):325-326
    Department of Ophthalmology, Al-Khidmat Teaching Hospital, Mansoora / University College of Medicine and Dentistry, University of Lahore, Lahore.
    Vogt-Koyanagi-Harada syndrome is a rare disease that occurs commonly in pigmented individuals of Asian origin. A 25-year female presented in medical outpatient department (OPD) of Al-Khidmat Teaching Hospital, Mansoora, Lahore with headache and neck stiffness. She was referred to eye OPD for the complaint of decreased vision. Read More

    Positron emission tomography/computed tomography scan of Vogt-Koyanagi-Harada syndrome with associated autoimmune thyroid disease: A case report and literature review.
    Medicine (Baltimore) 2018 Mar;97(9):e0047
    Department of Ophthalmology, Tri-Service General Hospital.
    Rationale: Vogt-Koyanagi-Harada (VKH) syndrome is a rare disease and could be associated with autoimmune thyroid disease (AITD). This report was aimed to investigate the utility of F-fludeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) for the diagnosis of VKH syndrome with AITD and to perform a literature review on the association between the 2 diseases.

    Patient Concerns: A 55-year-old woman without the history of ocular trauma suffered from chronic headache. Read More

    Association of human leukocyte antigen (HLA)-DQ and HLA-DQA1/DQB1 alleles with Vogt-Koyanagi-Harada disease: A systematic review and meta-analysis.
    Medicine (Baltimore) 2018 Feb;97(7):e9914
    Department of Ophthalmology, the First Affiliated Hospital of Jinan University.
    Objective: The aim of this study was to evaluate the association of human leukocyte antigen (HLA)-DQ and HLA-DQA1/DQB1 alleles with Vogt-Koyanagi-Harada (VKH), providing further evidences on the genetic background of this disease.

    Methods: A comprehensive literature search was conducted on the relationship of HLA-DQ and/or HLA-DQA1/DQB1 alleles with VKH through PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, VIP, and databases for grey literature. The last search was in October 2017. Read More

    How To Deal With Uveitis Patients?
    Curr Mol Med 2018 Mar;17(7):468-470
    The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, Chongqing Eye Institute, Chongqing, China.
    During the past nine years, our center has grown into the largest uveitis referral center in China. To deal with this increasing stream of patients we have developed a management system to coordinate communication with our patients, their referring ophthalmologists, consultations with other medical specialties and worldrenowned foreign uveitis specialists. We have established the biggest database of uveitis patients records allowing continuous analysis of clinical features and response to treatment of patients with various uveitis entities as well as the evaluation of the relevance of various ancillary tests performed in this patient group. Read More

    Longitudinal observation of subretinal fibrosis in Vogt-Koyanagi-Harada disease.
    BMC Ophthalmol 2018 Jan 15;18(1). Epub 2018 Jan 15.
    Ophthalmology Department, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, 1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing, 100730, China.
    Background: Subretinal fibrosis (SRF) is a vision-threatening complication of Vogt-Koyanagi-Harada disease (VKH). It has long been recognized as a sequela of chronic inflammation. The developmental process of SRF, however, has not been described. Read More

    Associations between , and and Behçet's disease but not VKH syndrome in Han Chinese.
    Oncotarget 2017 Dec 23;8(62):105037-105046. Epub 2017 Oct 23.
    The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, China.
    The present study was designed to explore the interrelationship between single nucleotide polymorphisms (SNP) of the tumor necrosis factor superfamily (TNFSF) and its respective receptor superfamily (TNFRSF) genes and Behcet's disease (BD) and Vogt-Koyanagi-Harada syndrome (VKH) in Han Chinese. The study sample included 796 patients with BD, 792 patients with VKH syndrome, and 1604 healthy controls. The genotyping of 35 SNPs was performed by MassARRAY platform (Sequenom), iPLEX Gold Assay, PCR-restriction fragment length polymorphism assay and TaqMan SNP assay. Read More

    Recovery of macular cone photoreceptors in Vogt-Koyanagi-Harada disease.
    Graefes Arch Clin Exp Ophthalmol 2018 Feb 20;256(2):387-394. Epub 2017 Dec 20.
    Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
    Purpose: Our purpose was to study changes in macular cone photoreceptors in Vogt-Koyanagi-Harada (VKH) disease patients after high-dose corticosteroid treatment using an adaptive optics (AO) fundus camera.

    Methods: We retrospectively analyzed 16 eyes of eight patients with new-onset acute VKH disease that were studied retrospectively. After serous retinal detachment (SRD) had resolved, AO images were obtained using the rtx1™ AO fundus camera over a 12-month course. Read More

    Association between CD40 rs1883832 and immune-related diseases susceptibility: A meta-analysis.
    Oncotarget 2017 Nov 28;8(60):102235-102243. Epub 2017 Jun 28.
    Department of Urology Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, 361003, China.
    Background/objective: It has been reported that CD40 rs1883832 might be associated with immune-related diseases susceptibility. Owing to mixed and inconclusive results, we conducted a meta-analysis of case-control studies to summarize and clarify this association.

    Methods/main Results: A systematic search of studies on the association between CD40 rs1883832 and immune-related diseases susceptibility was conducted in databases. Read More

    Current and Newly Emerging Autoimmune Diseases.
    Vet Clin North Am Small Anim Pract 2018 Mar 14;48(2):323-338. Epub 2017 Dec 14.
    Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, Vet Med 3A, Davis, CA 95616, USA. Electronic address:
    There are many autoimmune diseases that are recognized in domestic animals. The descriptions of diseases provide examples of the magnitude of immune targets and the variable nature of autoimmune diseases. Other autoimmune diseases that are recognized in dogs, cats, and horses include immune-mediated thrombocytopenia, VKH (Vogt-Koyanagi-Harada) ocular disease (dogs), and Evans syndrome (which includes both immune-mediated anemia and immune-mediated thrombocytopenia). Read More

    Treatment of Ipilimumab-Induced Vogt-Koyanagi-Harada Syndrome With Oral Dexamethasone.
    Ophthalmic Surg Lasers Imaging Retina 2017 Nov;48(11):928-931
    The author presents a retrospective case report of a 54-year-old male with ipilimumab (Yervoy; Bristol-Myers Squibb, New York City, NY)-induced Vogt-Koyanagi-Harada Disease (VKH), which consisted of uveitis, optic neuritis, and choroiditis that was successfully treated with oral dexamethasone. The patient demonstrated resolution of uveitis, optic neuritis, and choroiditis 1 month following initiation of oral dexamethasone. Ipilimumab is a recently approved therapy for malignant melanoma. Read More

    Partial Vogt-Koyanagi-Harada syndrome as a differential diagnosis of optical neuritis.
    Mult Scler Relat Disord 2017 Oct 15;17:128-129. Epub 2017 Jul 15.
    NNH-Neurology Neuroscience and Headache, Santos, SP, Brazil; Universidade Metropolitana de Santos, Santos, SP, Brazil. Electronic address:

    [Optical coherence tomography angiography of acute Vogt-Koyanagi-Harada disease].
    Zhonghua Yan Ke Za Zhi 2017 Oct;53(10):735-739
    Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
    To measure vascular density in retinal and choroidal capillary layers by optical coherence tomography angiography (OCTA) and to explore their potential clinical values in Vogt-Koyanagi-Harada disease (VKH). This is a cross-sectional case-control study. Twenty-one acute VKH cases presented to Peking Union Medical College Hospital between April 2015 and July 2015 and 49 healthy controls were enrolled in this study. Read More

    Acute Angle Closure Secondary to Tubercular Choroidal Granuloma.
    J Glaucoma 2017 Dec;26(12):e264-e267
    Advanced Eye Centre.
    Acute angle closure is usually thought to be secondary to pupillary block, which is relieved by laser iridotomy. Anterior rotation of the ciliary body at the scleral spur following development of an inflammatory ciliochoroidal detachment may result in a presentation of acute angle closure. It is imperative to recognize this condition correctly, because the management is with cycloplegics and anti-inflammatory drugs, which is diametrically opposite to the treatment of primary angle closure. Read More

    Anti-TNFα therapy and switching in severe uveitis related to Vogt-Koyanagi-Harada syndrome.
    Eur J Rheumatol 2017 09 21;4(3):226-228. Epub 2017 Jun 21.
    Division of Neurology, Hospital Universitario Lozano Blesa, Zaragoza, Spain.
    The study aimed to describe the effectiveness of switching the anti-TNFα agent when an acceptable clinical response has not been obtained with the first anti-TNFα agent in patients with uveitis in VKH syndrome. Patients diagnosed with VKH syndrome being evaluated from the uveitis unit of a single tertiary hospital from January 1, 2000, to October 30, 2015. Patients who presented uveitis with an inadequate response to a first anti-TNFα and required switching to a second anti-TNFα were selected. Read More

    [Vitiligo revealing Vogt -Koyanagi-Harada disease].
    Pan Afr Med J 2017 24;27:220. Epub 2017 Jul 24.
    Service de Dermatologie-Vénéréologie, Hôpital Militaire d'Instruction Mohammed V, Rabat, Maroc.
    Vitiligo is a chronic auto-immune skin disease, often associated or discovers other autoimmune pathologies. His association with Ophthalmological type pan uveitis and/or neurological type of meningitis and/or inner ear type of hearing loss determines the disease or Vogt -Koyanagi-Harada syndrome (VKH). We related the case of a young woman who consulted for recurrent uveitis for a year, and it was only with the onset of vitiligo lesions that VKH disease diagnosis was discussed and confirmed. Read More

    Lord Nelson's (1758-1805) left eye.
    J Med Biogr 2017 Jan 1:967772015624391. Epub 2017 Jan 1.
    William Pryse-Phillips, Memorial University of Newfoundland, St. John's, Newfoundland, Canada.
    Following the loss of his right eye at Calvi in 1794, Lord Nelson suffered increasing left-sided visual loss, here considered most likely to have been due to the ocular inflammatory condition 'sympathetic ophthalmia'. It is also argued that his succeeding episodes of violent headaches with nausea and prostration, and possible depigmentation of hair, reflected the development of an uveomeningoencephalitic syndrome akin to that of Vogt-Koyanagi-Harada disease, which is best regarded as the same condition with a different aetiology. Read More

    MicroRNA-20a-5p suppresses IL-17 production by targeting OSM and CCL1 in patients with Vogt-Koyanagi-Harada disease.
    Br J Ophthalmol 2018 02 28;102(2):282-290. Epub 2017 Sep 28.
    The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Lab of Ophthalmology, Chongqing Eye Institute, Chongqing, China.
    Aim: To elucidate the role of microRNA-20a-5p (miR-20a-5p) in the pathogenesis of Vogt-Koyanagi-Harada (VKH) disease.

    Methods: Quantitative real-time PCR was used to quantify miR-20a-5p expression in CD4 T cells from patients with active VKH and normal controls. The promoter methylation status of miR-20a-5p was detected by bisulfite sequencing PCR. Read More

    Vogt-Koyanagi-Harada Syndrome in a Group of Patients in Two Ophthalmology Referral Centers in Bogotá, Colombia.
    Ocul Immunol Inflamm 2017 Sep 14:1-5. Epub 2017 Sep 14.
    a Fundación Oftalmológica Nacional (FUNDONAL) , Uveitis Service , Bogotá , Columbia.
    Purpose: To describe the clinical presentation of Vogt-Koyanagi-Harada (VKH) syndrome in a group of patients in Colombia.

    Methods: Retrospective review of 2638 medical records of patients with uveitis in two centers during 17 years.

    Results: A total of 25 patients with uveitis were diagnosed with VKH syndrome (0. Read More

    Polarization-Sensitive Optical Coherence Tomographic Documentation of Choroidal Melanin Loss in Chronic Vogt-Koyanagi-Harada Disease.
    Invest Ophthalmol Vis Sci 2017 09;58(11):4467-4476
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan.
    Purpose: Vogt-Koyanagi-Harada (VKH) disease is a systemic autoimmune disorder that affects organs with melanocytes. The sunset glow fundus (SGF) in VKH disease was evaluated with polarization-sensitive optical coherence tomography (PS-OCT).

    Methods: The study involved 28 eyes from 14 patients with chronic VKH disease, 21 eyes from 21 age-matched controls, and 22 eyes from 22 high-myopic patients with a tessellated fundus. Read More

    Association of a PDCD1 Polymorphism With Sympathetic Ophthalmia in Han Chinese.
    Invest Ophthalmol Vis Sci 2017 08;58(10):4218-4222
    The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, People's Republic of China.
    Purpose: Several studies have shown that sympathetic ophthalmia (SO) and Vogt-Koyanagi-Harada (VKH) disease possess many similarities concerning their clinical manifestations. The aim of this study was to investigate whether single nucleotide polymorphisms that have been shown to be associated with VKH disease in earlier studies may also be associated with SO.

    Methods: There were 114 SO patients and 1230 healthy controls included in a case-control study, whereby 24 VKH-related single nucleotide polymorphisms (SNPs) were tested. Read More

    [Vogt-Koyanagi-Harada syndrome].
    Rev Med Liege 2017 Jul;72(7-8):354-357
    Service d'Ophtalmologie, CHU de Liège, site Sart Tilman, Liège, Belgique.
    We present the case of a patient who had a decrease of the visual acuity associated with headaches, diagnosed as vogt-koyanagi-harada syndrome. This is a rare multisystemic pathology that affects organs with high concentration of melanocytes. This syndrome needs to be identified on time as corticotherapy has to be administrated urgently. Read More

    Expression and role of interleukin-9 in Vogt-Koyanagi-Harada disease.
    Mol Vis 2017 31;23:538-547. Epub 2017 Jul 31.
    The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
    Purpose: Vogt-Koyanagi-Harada (VKH) disease is a systemic autoimmune disease that can lead to blindness. This study was designed to investigate whether interleukin (IL)-9 plays a role in the development of VKH disease.

    Methods: IL-9, IL-17, and interferon (IFN)-γ levels, present in the supernatants of cultured peripheral blood mononuclear cells (PBMCs) and CD4+T cells, were assessed with enzyme-linked immunosorbent assay. Read More

    Clinical Features of Pregnancy-associated Retinal and Choroidal Diseases Causing Acute Visual Disturbance.
    Korean J Ophthalmol 2017 Aug 25;31(4):320-327. Epub 2017 Jul 25.
    Department of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
    Purpose: To report clinical features of patients with retinal and choroidal diseases presenting with acute visual disturbance during pregnancy.

    Methods: In this retrospective case series, patients who developed acute visual loss during pregnancy (including puerperium) and visited a tertiary hospital from July 2007 to June 2015, were recruited by searching electronic medical records. Patients were categorized according to the cause of visual loss. Read More

    [The fundus manifestations and SD-OCT findings of patients with acute Vogt-Koyanagi-Harada disease].
    Zhonghua Yan Ke Za Zhi 2017 Jun;53(6):436-439
    Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences Beijing 100730, China.
    To conclude the characteristics of fundus appearance and spectral domain optical coherence tomography(SD-OCT) findings of patients with acute Vogt-Koyanagi-Harada (VKH) disease. The clinical data of 17 patients (34 eyes) diagnosed of acute VKH in Peking Union Medical College Hospital from Jan. 2012 to Dec. Read More

    The Association of Chemokine Gene Polymorphisms with VKH and Behcet's Disease in a Chinese Han Population.
    Biomed Res Int 2017 14;2017:1274960. Epub 2017 May 14.
    The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, China.
    To investigate the association of chemokine gene polymorphisms and Behcet's disease (BD) and Vogt Koyanagi Harada (VKH) disease in a Chinese Han population. A case-control study was performed. Three hundred and seventy-one BD patients, 371 VKH disease patients, and 605 healthy controls were recruited to determine genetic variants of 26 SNPs in 12 chemokine genes with iPLEX Gold genotyping assay and Sequenom MassARRAY or TaqMan SNP assays. Read More

    Management of a rare presentation of Vogt-Koyanagi-Harada disease in human immunodeficiency virus/acquired immunodeficiency disease syndrome patient.
    Indian J Ophthalmol 2017 May;65(5):413-416
    Department of Uvea and Ocular Pathology, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India.
    Vogt-Koyanagi-Harada (VKH), a multisystem autoimmune bilateral panuveitis with systemic manifestations, is uncommon in immunocompromised patients such as human immunodeficiency virus (HIV)/acquired immunodeficiency disease syndrome (AIDS). We report a rare presentation of VKH in a 45-year-old HIV-positive female on highly active antiretroviral therapy (HAART) who presented with a history of recurrent panuveitis. A diagnosis of probable VKH was made based on ocular and systemic signs and symptoms. Read More

    Vogt-Koyanagi-Harada disease in a patient of chronic myeloid leukemia.
    Indian J Ophthalmol 2017 May;65(5):411-413
    Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All Institute of Medical Sciences, New Delhi, India.
    This case report describes the concurrent development of Vogt-Koyanagi-Harada (VKH) disease in a 39 year old male patient of chronic myeloid leukemia (CML). The patient being reported was a known case of CML in remission with history of painless sudden loss of vision in both eyes. Cases of leukemia can present with visual loss due to multiple ocular manifestations of leukemia itself or side effects of modern drugs used for its treatment. Read More

    Evaluation of the Glucocorticoid Receptor as a Biomarker of Treatment Response in Vogt-Koyanagi-Harada Disease.
    Invest Ophthalmol Vis Sci 2017 02;58(2):974-980
    Physiology Program, School of Medicine, Universidad de Chile, Santiago, Chile 4Rheumatology Service, Department of Medicine, Hospital Clinico Universidad de Chile, Santiago, Chile.
    Purpose: This study is aimed to investigate the role of glucocorticoid receptor (GR) isoforms in peripheral blood mononuclear cells (PBMC) as biomarkers of glucocorticoid (GC) resistance and to validate a set of clinical predictive factors in patients with Vogt-Koyanagi-Harada (VKH) disease.

    Methods: This was a prospective cohort study that included a total of 21 patients with VKH. A complete ophthalmologic evaluation was carried out at baseline that recorded the presence of any clinical predictive factors (visual acuity ≤ 20/200, tinnitus, chronic disease, and fundus depigmentation). Read More

    [Clinical features, risk factors and progresses on treatment of recurrent Vogt-Koyanagi-Harada disease].
    Zhonghua Yan Ke Za Zhi 2017 Apr;53(4):317-320
    Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
    Vogt-Koyanagi-Harada disease(VKH) is a bilateral, granulomatous panuveitis associated with central nervous system, auditory, and integumentary manifestations. Clinically, VKH usually responds well to early aggressive glucocorticosteroid treatment and may be cured without any clinically significant sequelae. Some patients, however, may enter the chronic recurrent phase, which may result in marked loss of vision due to complications such as complicated cataract, secondary glaucoma and maculopathy. Read More

    Tuberculous Posterior Sclero-Uveitis with Features of Vogt-Koyanagi-Harada Uveitis: An Unusual Case.
    Am J Case Rep 2017 Apr 8;18:367-374. Epub 2017 Apr 8.
    Department of Ophthalmology, School of Health Sciences, Faculty of Medicine, University of Ioannina, Ioannina, Greece.
    BACKGROUND Ocular tuberculosis (TB) is a clinical entity that presents with a wide range of clinical manifestations. It is regarded as an extremely challenging condition from the point of view of diagnostic approach and calls for early diagnosis and prompt treatment, as it can potentially lead to blindness. CASE REPORT This is a case report of a 32-year-old male from southern India who has been living and working in Greece over the last 10 years and presented with 2-week history of pain and progressive visual impairment of his left eye. Read More

    The effect on choroidal changes of the route of systemic corticosteroids in acute Vogt-Koyanagi-Harada disease.
    Graefes Arch Clin Exp Ophthalmol 2017 Jun 5;255(6):1203-1211. Epub 2017 Apr 5.
    Department of Ophthalmology, College of Medicine, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul, 110-799, South Korea.
    Purpose: To determine whether route of corticosteroid administration during the acute stage of Vogt-Koyanagi-Harada (VKH) disease affects depigmentary change and subfoveal choroidal thickness (SCT) during the convalescent stage.

    Methods: In this retrospective comparative study, VKH patients with the interval between diagnosis and final follow-up of ≥ 24 months were divided into two groups according to route of systemic corticosteroid; intravenous pulse therapy (IV pulse group) and oral administration (oral group). Sunset glow fundus (SGF) scores determined by ultra-wide field retinal imaging and SCT determined by enhanced depth imaging optical coherence tomography were compared. Read More

    A challenged case of Vogt-Koyanagi-Harada syndrome: when dermatological manifestations came first.
    Int Ophthalmol 2017 Mar 30. Epub 2017 Mar 30.
    Hospital Prof Doutor Fernando Fonseca, Lisbon, Portugal.
    Introduction: Vogt-Koyanagi-Harada syndrome (VKHS) is an inflammatory systemic autoimmune disease principally affecting pigmented tissues in the ocular, auditory, integumentary and central nervous systems. Patients are generally women in the fourth decade of life. The prognosis is correlated mainly with the time between diagnosis and the start of treatment and number of recurrent episodes of inflammation. Read More

    Multi-modal imaging and anatomic classification of the white dot syndromes.
    Int J Retina Vitreous 2017 20;3:12. Epub 2017 Mar 20.
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, 600 Highland Ave, Madison, WI 53705 USA.
    The white dot syndromes (WDS) are a diverse group of posterior uveitidies that share similar clinical findings but are unique from one another. Multimodal imaging has allowed us to better understand the morphology, the activity and age of lesions, and whether there is CNV associated with these different ocular pathologies. The "white dot syndromes" and their uveitic masqueraders can now be anatomically categorized based on lesion localization. Read More

    Vogt Koyanagi Harada Syndrome mimicking multiple sclerosis: A case report and review of the literature.
    Mult Scler Relat Disord 2017 Feb 6;12:44-48. Epub 2017 Jan 6.
    Najran University, Najran, Saudi Arabia.
    Vogt Koyanagi Harada (VKH) Syndrome, also called uveomeningioencephalitis, is a chronic disorder characterized by inflammation of the uvea, meninges, auditory system, and integumentary system. The association between VKH syndrome and multiple sclerosis (MS) has been reported only once in the literature in a patient who developed VKH syndrome after two years of the diagnosis of MS. In this article, we report a case who was misdiagnosed and treated as MS until she was proven to have VKH syndrome, and a diagnosis of MS was excluded. Read More

    Promoter Hypermethylation of GATA3, IL-4, and TGF-β Confers Susceptibility to Vogt-Koyanagi-Harada Disease in Han Chinese.
    Invest Ophthalmol Vis Sci 2017 03;58(3):1529-1536
    The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, China.
    Purpose: We investigated the role of promoter methylation of transcriptional and inflammatory factors, including TBX21, GATA3, RORγt, FOXP3, IFN-γ, IL-4, IL-17A, and TGF-β in the development of Vogt-Koyanagi-Harada (VKH) disease.

    Methods: The promoter methylation levels were detected by the Sequenom MassARRAY system in CD4+ T cells that were separated from 20 healthy individuals and 32 VKH patients (20 in the active stage without medication, 12 in inactive stage with medication). The mRNA expression level of GATA3, IL-4, and TGF-β in CD4+ T cells was analyzed by real-time RT-PCR. Read More

    Early post-treatment choroidal thickness to alert sunset glow fundus in patients with Vogt-Koyanagi-Harada disease treated with systemic corticosteroids.
    PLoS One 2017 27;12(2):e0172612. Epub 2017 Feb 27.
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
    Purpose: To determine if early post-treatment central choroidal thickness (CCT) changes can predict sunset glow fundus (SGF) development in patients with Vogt-Koyanagi-Harada (VKH) disease treated using systemic corticosteroids.

    Methods: This retrospective case series included 39 eyes of 21 treatment-naïve patients with acute VKH disease who could be followed up for more than 12 months after systemic corticosteroid therapy. The eyes were divided into two groups according to whether SGF was present or absent at 12 months (9 eyes of 5 patients versus 30 eyes of 16 patients, respectively). Read More

    Vogt-Koyanagi-Harada-like Syndrome Complicating Pembrolizumab Treatment for Metastatic Melanoma.
    J Immunother 2017 Feb/Mar;40(2):77-82
    Departments of *Ophthalmology †Dermatology, LYON SUD Hospital Center, Hospices Civils of Lyon, Pierre Bénite Cedex Departments of ‡Internal Medicine §Ophthalmology, Croix-Rousse Hospital, Hospices Civils of Lyon, Lyon, France.
    Vogt-Koyanagi-Harada (VKH) syndrome is a rare condition implicating systemic immune reaction against melanocytes. The pathophysiology is unclear. A genetic predisposition has been suggested as HLA-DR4/DRB1*04 is more common among VKH patients. Read More

    Distinguishing features of acute Vogt-Koyanagi-Harada disease and acute central serous chorioretinopathy on optical coherence tomography angiography and en face optical coherence tomography imaging.
    J Ophthalmic Inflamm Infect 2017 Dec 13;7(1). Epub 2017 Jan 13.
    Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India.
    Background: The aim of this study is to determine the differences in optical coherence tomography angiography (OCTA) features of acute Vogt-Koyanagi-Harada disease (VKH) and acute central serous chorioretinopathy (CSC). Clinical and imaging data of patients with acute CSC and VKH in a tertiary-care institute were analyzed. Multimodal imaging including fluorescein angiography, indocyanine green angiography (ICGA), and enhanced-depth imaging OCT were performed. Read More

    Vogt-Koyanagi-Harada syndrome (uveomeningoencephalitic syndrome).
    Eur J Ophthalmol 2017 Jan 19;27(1):e5-e8. Epub 2017 Jan 19.
    Department of Ophthalmology, Central Military University Hospital, Prague - Czech Republic.
    Purpose: To report a case of a 29-year-old man who was examined at the Eye Clinic of Central Military University Hospital Prague for a severe headache and acute blurring of vision in both eyes diagnosed as incomplete Vogt-Koyanagi-Harada syndrome (VKH).

    Methods: This is a retrospective and descriptive case report based on data from clinical records, patient observation and follow-ups and analysis of acquired diagnostic tests.

    Results: A 29-year-old man presented with headache and decreased vision in his left eye (LE) for 2 days. Read More

    [Vogt-Koyanagi-Harada Syndrome : An unusual case with lacquer crack-like retinal findings].
    Ophthalmologe 2017 Dec;114(12):1158-1161
    Augenklinik, Universitätsklinikum Dokuz Eylul, Izmir, Türkei.
    We report the case of a 35-year-old female patient with bilateral and recurrent panuveitis. Diagnosed with Vogt-Koyanagi-Harada syndrome, the patient was treated with corticosteroids, achieving rapid improvement of functional and morphological findings. After recovery of the exudative retinal detachment, peripapillary lacquer crack-like findings were observed. Read More

    Successful Treatment of Vitiligo Associated with Vogt-Koyanagi-Harada Disease.
    Pediatr Dermatol 2017 Mar 16;34(2):204-205. Epub 2016 Dec 16.
    Division of Pediatric Dermatology, Departments of Dermatology and Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin.
    Vogt-Koyanagi-Harada disease (VKH) is a rare multisystem disorder with cutaneous, ophthalmic, neurologic, and auditory manifestations. There is a paucity of published literature regarding the management of cutaneous features in VKH. We report a case of VKH-associated vitiligo responsive to topical corticosteroids and topical calcineurin inhibitors. Read More

    Vogt-Koyanagi-Harada syndrome - current perspectives.
    Clin Ophthalmol 2016 24;10:2345-2361. Epub 2016 Nov 24.
    Uveitis Service, Moorfields Eye Hospital, London, UK; Department of Clinical Ophthalmology, UCL Institute of Ophthalmology, London, UK; Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel.
    Vogt-Koyanagi-Harada syndrome is a cause of noninfectious panuveitis, leading to significant vision loss in many patients. It is an autoimmune disease occurring in genetically susceptible individuals and clinically presents as bilateral panuveitis with serous retinal detachments and hyperemic, swollen optic discs, which are associated with neurological and auditory manifestations. Early diagnosis and prompt and adequate treatment with immunosuppressive agents (corticosteroids and other immunosuppressive drugs) may halt disease progression and prevent recurrences and vision loss. Read More

    A Rare Case of Unilateral Progressive Vision Loss and Pachymeningitis.
    Neuroophthalmology 2016 Oct 11;40(5):237-242. Epub 2016 Aug 11.
    Department of Neurology, University of Illinois College of Medicine, Peoria, Peoria, Illinois, USA; Illinois Neurologic Institute, Peoria, Illinois, USA.
    We describe a 32-year-old man with presumed Vogt-Koyanagi Harada (VKH) syndrome, whose presenting symptoms were headache and progressive loss of vision in the right eye. Neuro-ophthalmic examination showed anterior and posterior uveitis, and retinal detachment in the right eye. Ocular coherence tomography (OCT) showed extensive submacular fluid in the right eye, while the fundus fluorescein angiogram (FFA) confirmed perifoveal retinal pigment epithelium (RPE) disruption and multifocal fluorescein leakage in the right eye. Read More

    Managing macular hole associated with acute inflammatory Vogt-Koyanagi-Harada syndrome.
    Int J Retina Vitreous 2015 3;1:18. Epub 2015 Nov 3.
    Vitreoretinal Diseases Unit, Brazilian Institute of Fighting Against Blindness, São Paulo, Brazil.
    We report a 24-year-old man with Vogt-Koyanagi-Harada (VKH) syndrome who developed a macular hole (MH) during the acute inflammatory stage. Spontaneous resolution was unlikely because of the MH dimensions and absence of vitreous adherence. The patient underwent pars plana vitrectomy (PPV) and internal limiting membrane peeling during the acute stage followed by retinopexy with octafluoropropane injection and prone positioning for 5 days. Read More

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