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    1207 results match your criteria Vogt-Koyanagi-Harada Syndrome

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    Vogt-Koyanagi-Harada-like Syndrome Complicating Pembrolizumab Treatment for Metastatic Melanoma.
    J Immunother 2017 Feb/Mar;40(2):77-82
    Departments of *Ophthalmology †Dermatology, LYON SUD Hospital Center, Hospices Civils of Lyon, Pierre Bénite Cedex Departments of ‡Internal Medicine §Ophthalmology, Croix-Rousse Hospital, Hospices Civils of Lyon, Lyon, France.
    Vogt-Koyanagi-Harada (VKH) syndrome is a rare condition implicating systemic immune reaction against melanocytes. The pathophysiology is unclear. A genetic predisposition has been suggested as HLA-DR4/DRB1*04 is more common among VKH patients. Read More

    Distinguishing features of acute Vogt-Koyanagi-Harada disease and acute central serous chorioretinopathy on optical coherence tomography angiography and en face optical coherence tomography imaging.
    J Ophthalmic Inflamm Infect 2017 Dec 13;7(1). Epub 2017 Jan 13.
    Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India.
    Background: The aim of this study is to determine the differences in optical coherence tomography angiography (OCTA) features of acute Vogt-Koyanagi-Harada disease (VKH) and acute central serous chorioretinopathy (CSC). Clinical and imaging data of patients with acute CSC and VKH in a tertiary-care institute were analyzed. Multimodal imaging including fluorescein angiography, indocyanine green angiography (ICGA), and enhanced-depth imaging OCT were performed. Read More

    Vogt-Koyanagi-Harada syndrome (uveomeningoencephalitic syndrome).
    Eur J Ophthalmol 2017 Jan 19;27(1):e5-e8. Epub 2017 Jan 19.
    Department of Ophthalmology, Central Military University Hospital, Prague - Czech Republic.
    Purpose: To report a case of a 29-year-old man who was examined at the Eye Clinic of Central Military University Hospital Prague for a severe headache and acute blurring of vision in both eyes diagnosed as incomplete Vogt-Koyanagi-Harada syndrome (VKH).

    Methods: This is a retrospective and descriptive case report based on data from clinical records, patient observation and follow-ups and analysis of acquired diagnostic tests.

    Results: A 29-year-old man presented with headache and decreased vision in his left eye (LE) for 2 days. Read More

    [Vogt-Koyanagi-Harada Syndrome : An unusual case with lacquer crack-like retinal findings].
    Ophthalmologe 2016 Dec 22. Epub 2016 Dec 22.
    Augenklinik, Universitätsklinikum Dokuz Eylul, Izmir, Türkei.
    We report the case of a 35-year-old female patient with bilateral and recurrent panuveitis. Diagnosed with Vogt-Koyanagi-Harada syndrome, the patient was treated with corticosteroids, achieving rapid improvement of functional and morphological findings. After recovery of the exudative retinal detachment, peripapillary lacquer crack-like findings were observed. Read More

    Vogt-Koyanagi-Harada syndrome - current perspectives.
    Clin Ophthalmol 2016 24;10:2345-2361. Epub 2016 Nov 24.
    Uveitis Service, Moorfields Eye Hospital, London, UK; Department of Clinical Ophthalmology, UCL Institute of Ophthalmology, London, UK; Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel.
    Vogt-Koyanagi-Harada syndrome is a cause of noninfectious panuveitis, leading to significant vision loss in many patients. It is an autoimmune disease occurring in genetically susceptible individuals and clinically presents as bilateral panuveitis with serous retinal detachments and hyperemic, swollen optic discs, which are associated with neurological and auditory manifestations. Early diagnosis and prompt and adequate treatment with immunosuppressive agents (corticosteroids and other immunosuppressive drugs) may halt disease progression and prevent recurrences and vision loss. Read More

    A Rare Case of Unilateral Progressive Vision Loss and Pachymeningitis.
    Neuroophthalmology 2016 Oct 11;40(5):237-242. Epub 2016 Aug 11.
    Department of Neurology, University of Illinois College of Medicine, Peoria, Peoria, Illinois, USA; Illinois Neurologic Institute, Peoria, Illinois, USA.
    We describe a 32-year-old man with presumed Vogt-Koyanagi Harada (VKH) syndrome, whose presenting symptoms were headache and progressive loss of vision in the right eye. Neuro-ophthalmic examination showed anterior and posterior uveitis, and retinal detachment in the right eye. Ocular coherence tomography (OCT) showed extensive submacular fluid in the right eye, while the fundus fluorescein angiogram (FFA) confirmed perifoveal retinal pigment epithelium (RPE) disruption and multifocal fluorescein leakage in the right eye. Read More

    Managing macular hole associated with acute inflammatory Vogt-Koyanagi-Harada syndrome.
    Int J Retina Vitreous 2015 3;1:18. Epub 2015 Nov 3.
    Vitreoretinal Diseases Unit, Brazilian Institute of Fighting Against Blindness, São Paulo, Brazil ; grid.411249.b0000000105147202Vitreoretinal Diseases Unit, Federal University of São Paulo, Vision Institute, São Paulo, Brazil.
    We report a 24-year-old man with Vogt-Koyanagi-Harada (VKH) syndrome who developed a macular hole (MH) during the acute inflammatory stage. Spontaneous resolution was unlikely because of the MH dimensions and absence of vitreous adherence. The patient underwent pars plana vitrectomy (PPV) and internal limiting membrane peeling during the acute stage followed by retinopexy with octafluoropropane injection and prone positioning for 5 days. Read More

    Choroidal circulation impairment during the anterior recurrence of Vogt-Koyanagi-Harada disease confirmed with indocyanine green angiography and laser speckle flowgraphy.
    Acta Ophthalmol 2016 Nov 15;94(7):e629-e636. Epub 2016 Apr 15.
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
    Purpose: To assess choroidal inflammation-related circulatory changes associated with the anterior recurrence of Vogt-Koyanagi-Harada (VKH) disease, using indocyanine green angiography (ICGA) and laser speckle flowgraphy (LSFG).

    Methods: This retrospective case series included 17 eyes of 11 patients with VKH disease showing recurrent inflammatory findings in the anterior, but not posterior, segment (i.e. Read More

    Sequence analysis of four vitamin D family genes (VDR, CYP24A1, CYP27B1 and CYP2R1) in Vogt-Koyanagi-Harada (VKH) patients: identification of a potentially pathogenic variant in CYP2R1.
    BMC Ophthalmol 2016 Oct 4;16(1):172. Epub 2016 Oct 4.
    Center for Genetics and Inherited Diseases, Taibah University Almadinah Almunawarah, Medina, 30001, Kingdom of Saudi Arabia.
    Background: VKH is a rare autoimmune disease. Decreased level of vitamin D has recently been found to be involved in the pathogenesis of Vogt-Koyanagi-Harada (VKH) disease. This study was designed to screen the vitamin D pathway genes for pathogenic mutations, if any, in VKH patients. Read More

    Personality and uveitis.
    J Ophthalmic Inflamm Infect 2016 Dec 6;6(1):36. Epub 2016 Oct 6.
    Cataract and Refractive Department, Narayana Nethralaya, Bangalore, India.
    Background: Psycho-immunology is an emerging branch of science which studies the interaction between the brain and the immune system. The purpose of this study is to identify the types of personality factors in patients with non-infectious uveitis and to find its association with a particular uveitic entity if any. This is a prospective, observational, case-control study of 186 patients with non-infectious uveitis (group A) and controls from general ophthalmology outpatient department (group B). Read More

    Contralateral Autologous Corneal Transplantation Experience in Mexico City.
    Cornea 2017 Jan;36(1):32-36
    Cornea and Refractive Surgery Division, Asociación Para Evitar la Ceguera, Universidad Nacional Autónoma de México, Mexico City, Mexico.
    Purpose: The aim of this study is to expand the limited knowledge regarding autologous contralateral penetrating keratoplasty.

    Methods: We report the retrospective outcomes of patients who received autokeratoplasty and contralateral opaque corneas in the donor eye at a tertiary care ophthalmology hospital in Mexico City.

    Results: Eleven patients received autokeratoplasty and contralateral opaque corneas in the donor eye at our center from 2010 to 2015. Read More

    A case of unilateral and spontaneously resolving posterior uveitis with overlapping features of Vogt-Koyanagi-Harada disease and Acute Posterior Multifocal Placoid Pigment Epitheliopathy.
    Springerplus 2016 1;5(1):1471. Epub 2016 Sep 1.
    Ivey Eye Institute, Western University, London, ON Canada.
    Introduction: VKH disease is a chronic, bilateral, granulomatous panuveitis with potential involvement of neurological, auditory and integumentary systems. On the other hand, APMPPE is believed to be an immune-driven chorioretinal vascular disease characterized by multifocal, flat, grey-white placoid lesions at the level of the RPE. We describe a case with overlapping figures of both conditions. Read More

    Mycophenolate mofetil combined with systemic corticosteroids prevents progression to chronic recurrent inflammation and development of 'sunset glow fundus' in initial-onset acute uveitis associated with Vogt-Koyanagi-Harada disease.
    Acta Ophthalmol 2017 Feb 18;95(1):85-90. Epub 2016 Aug 18.
    Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
    Purpose: To evaluate the effectiveness and safety of mycophenolate mofetil (MMF) as first-line therapy combined with systemic corticosteroids in initial-onset acute uveitis associated with Vogt-Koyanagi-Harada (VKH) disease.

    Methods: This prospective study included 38 patients (76 eyes). The main outcome measures were final visual acuity, corticosteroid-sparing effect, progression to chronic recurrent granulomatous uveitis and development of complications, particularly 'sunset glow fundus'. Read More

    Patterns and Etiologies of Uveitis at a Tertiary Referral Center in Taiwan.
    Ocul Immunol Inflamm 2016 Jul 27:1-8. Epub 2016 Jul 27.
    a Department of Ophthalmology , Kaohsiung Veterans General Hospital , Kaohsiung , Taiwan and.
    Purpose: To analyze the patterns and etiologies of uveitis at a tertiary referral center in Taiwan.

    Methods: This retrospective chart review of uveitis patients from January 2001 to December 2014 updates a previous study a decade ago (2003).

    Results: We identified 450 patients, among whom anterior uveitis was most common, followed by panuveitis, posterior uveitis, and intermediate uveitis. Read More

    The Role of Optical Coherence Tomography Angiography in the Diagnosis and Management of Acute Vogt-Koyanagi-Harada Disease.
    Ocul Immunol Inflamm 2016 Jul 20:1-12. Epub 2016 Jul 20.
    a Advanced Eye Center , Post Graduate Institute of Medical Education and Research , Chandigarh , India.
    Purpose: To report the imaging characteristics of acute Vogt-Koyanagi-Harada (VKH) disease using optical coherence tomography angiography (OCTA).

    Methods: In this prospective study, patients with acute VKH (n = 10; mean age: 30.5 ± 13. Read More

    The Relationship of Vogt-Koyanagi-Harada Syndrome to Ocular Hypertension and Glaucoma.
    Ocul Immunol Inflamm 2016 Jul 20:1-5. Epub 2016 Jul 20.
    a Department of Ophthalmology , Duke University Medical Center , Durham , North Carolina , USA.
    Purpose: Vogt-Koyanagi-Harada (VKH) syndrome is a systemic inflammatory autoimmune disease with associated ophthalmic pathology. Glaucoma has been reported in patients with VKH. The purpose of this report is to examine the frequency and types of glaucoma associated with VKH. Read More

    [Vogt-Koyanagi-Harada syndrome].
    Rev Fac Cien Med Univ Nac Cordoba 2016 ;73(2):132-3
    Instituto de Oftalmología "Conde de Valenciana", México DF, México.
    The Vogt-Koyanagi-Harada syndrome is a disease with dermatological, neurologic and auditory findings, associated with a bilateral granulomatous panuveitis. We present the case of a 42-year-old woman who started with ophthalmic manifestations, and in a late follow-up she developed the characteristic dermatological findings. Read More


    Extremely early stage osteonecrosis of the femoral head in a patient with hip pain secondary systemic steroid pulse therapy for Vogt-Koyanagi-Harada syndrome: A case report.
    Int J Surg Case Rep 2016 15;25:97-101. Epub 2016 Jun 15.
    Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Shogoin, Kawahara-cho 54, Sakyo-ku, Kyoto 606-8507, Japan.
    Introduction: Osteonecrosis of the femoral head (ONFH) is a corticosteroid-associated disease that mostly cause femoral head collapse and gait disturbance. At the final stage of ONFH, the most reliable treatment is total hip arthroplasty even in young patients. Although magnetic resonance imaging (MRI) is useful for early diagnosis, initial stages are asymptomatic, with pain intensifying after femoral head collapse. Read More

    Association of Vogt Koyanagi Harada Syndrome and Seronegative Rheumatoid Arthritis.
    Ethiop J Health Sci 2016 Mar;26(2):193-6
    Bezm-i Alem Foundation University School Of Medicine, Department Of Physical Therapy And Rehabilitation, Istanbul.
    Background: Vogt Koyanagi Harada (VKH) Syndrome is a rarely-seen multi-systemic, autoimmune and inflammatory disease. It observed frequently with neurologic, auditory and skin manifestations and characterized with bilateral, chronic and diffused granulomatous panuveitis. It generally affects women in young-adult period. Read More

    Ocular and orbital side-effects of checkpoint inhibitors: a review article.
    Curr Opin Oncol 2016 Jul;28(4):288-94
    aSaint Joseph University, Faculty of Medicine, Beirut, Lebanon bFondation ophtalmologique Adolphe de Rothschild cHôpital Bichat Claude Bernard, Faculté de Médecine Diderot Paris 7, France.
    Purpose Of Review: Checkpoint inhibitors have been increasingly considered as new targets for cancer therapies. Patients receiving checkpoint inhibitors develop many immune-related adverse events (IRAEs). However, ophthalmic IRAEs are rare and have been reported in less than 1% of patients. Read More

    Association of a NOS3 gene polymorphism with Behçet's disease but not with Vogt-Koyanagi-Harada syndrome in Han Chinese.
    Mol Vis 2016 3;22:311-8. Epub 2016 Apr 3.
    The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, P. R. China.
    Purpose: Previous studies have identified that nitric oxide synthase (NOS) genes are associated with several immune-mediated diseases. This study aimed to investigate whether NOS2 and NOS3 gene polymorphisms are associated with Behçet's disease (BD) and Vogt-Koyanagi-Harada (VKH) syndrome in a Han Chinese population.

    Methods: An association analysis of NOS2/rs4795067, NOS3/rs1799983 and NOS3/rs1800779 was performed in 733 patients with BD, 800 patients with VKH syndrome, and 1,359 controls using PCR restriction fragment length polymorphism (PCR-RFLP) assay. Read More

    Autoimmunity in visual loss.
    Handb Clin Neurol 2016 ;133:353-76
    Moorfields Eye Hospital, The National Hospital for Neurology and Neurosurgery and St. Thomas' Hospital, London, UK. Electronic address:
    There are a number of autoimmune disorders which can affect visual function. There are a very large number of mechanisms in the visual pathway which could potentially be the targets of autoimmune attack. In practice it is the retina and the anterior visual pathway (optic nerve and chiasm) that are recognised as being affected in autoimmune disorders. Read More

    Long-term Outcomes of Limited Vogt-Koyanagi-Harada Syndrome.
    Am J Ophthalmol 2016 Jul 8;167:52-6. Epub 2016 Apr 8.
    Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital and Ophthalmology, Department of Surgery, University of Melbourne, East Melbourne, Australia; Royal Victorian Eye and Ear Hospital, East Melbourne, Australia. Electronic address:
    Purpose: To describe the long-term outcomes of patients with limited Vogt-Koyanagi Harada syndrome (VKH), characterized by steroid-responsive serous retinal detachments without other signs of intraocular inflammation.

    Design: Retrospective case series.

    Methods: Consecutive patients from the Royal Victorian Eye and Ear Hospital with acute bilateral serous retinal detachments without anterior chamber inflammation, with no previous ocular history or trauma, and with negative screening for vasculitis and other systemic autoimmune disease were included. Read More

    Vogt-Koyanagi-Harada syndrome: Perspectives for immunogenetics, multimodal imaging, and therapeutic options.
    Autoimmun Rev 2016 Aug 7;15(8):809-19. Epub 2016 Apr 7.
    Massachusetts Eye Research and Surgery Institution, 1440 Main Street, Suite 20, Waltham, MA 02451, USA; Ocular Immunology and Uveitis Foundation, Waltham, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address:
    Vogt-Koyanagi-Harada syndrome (VKH) is a bilateral, diffuse granulomatous uveitis associated with neurological, audiovestibular, and dermatological systems. The primary pathogenesis is T-cell-mediated autoimmune response directed towards melanocyte or melanocyte-associated antigens causing inflammation of the choroidal layer. This phenomenon usually leads to diffuse inflammatory conditions throughout most parts of eye before ocular complications ensue. Read More

    Vogt-Koyanagi-Harada disease: review of a rare autoimmune disease targeting antigens of melanocytes.
    Orphanet J Rare Dis 2016 Mar 24;11:29. Epub 2016 Mar 24.
    Uveitis Service, Department of Ophthalmology, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, Rua Diana, 863 apto 91J, 05019-000, São Paulo, Brazil.
    Vogt-Koyanagi-Harada disease (VKHD) is a rare granulomatous inflammatory disease that affects pigmented structures, such as eye, inner ear, meninges, skin and hair. This disease is mainly a Th1 lymphocyte mediated aggression to melanocytes after a viral trigger in the presence of HLA-DRB1*0405 allele. The absence of ocular trauma or previous intraocular surgery sets VKHD appart from sympathetic ophthalmia, its main differential diagnosis. Read More

    Higher Expression of NOD1 and NOD2 is Associated with Vogt-Koyanagi-Harada (VKH) Syndrome But Not Behcet's Disease (BD).
    Curr Mol Med 2016 ;16(4):424-35
    First Affiliated Hospital of Chongqing Medical University, Youyi Road 1, Chongqing 400016, P.R. China.
    NOD1 and NOD2 have been found to play a significant regulatory role in autoimmune disease. To analyze the role of NOD1 and NOD2 in the pathogenesis of Vogt- Koyanagi-Harada (VKH) syndrome and Behcet's disease (BD). We analyzed the expression of NOD1 and NOD2 from PBMCs by RT-PCR and Western Blot. Read More

    Frequency of Uveitis in the Central Tokyo Area (2010-2012).
    Ocul Immunol Inflamm 2016 Mar 8:1-7. Epub 2016 Mar 8.
    b Department of Ophthalmology , Japan Community Healthcare Organization Tokyo Shinjuku Medical Center , Shinjuku-ku , Tokyo , Japan.
    Purpose: To investigate the frequency of conditions of newly arrived patients with uveitis from 2010 to 2012 and compare this frequency with that since 2004.

    Methods: We retrospectively analyzed clinical records of patients who visited the outpatient clinic from January 2010 to December 2012, and compared them with those from 2004-2009.

    Results: From 2010 to 2012, 695 new patients with uveitis visited Tokyo University Hospital, with a definite diagnosis made in 431 (62. Read More

    Multisystem diseases affecting the skin and eye.
    Clin Dermatol 2016 Mar-Apr;34(2):214-41. Epub 2015 Nov 22.
    Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. Electronic address:
    There exist a wide variety of multisystem diseases that can affect both the eyes and skin. The skin and eyes may be the initial sites affected, leading to a new diagnosis of a systemic illness, or severe skin and eye involvement can drive treatment for patients with multisystem disease. It is important for physicians to be aware of how to recognize and diagnose these conditions, to evaluate patients for extent of disease, and to initiate appropriate therapies to combat these potentially severe diseases. Read More

    Enhanced-Resolution Optical Coherence Tomography Imaging.
    Ophthalmologica 2016 23;235(3):163-72. Epub 2016 Feb 23.
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
    Purpose: The effect of the enhanced-resolution imaging (ERI) technique on optical coherence tomography (OCT) images was evaluated.

    Methods: A total of 5 healthy subjects and 20 patients diagnosed with various eye diseases were recruited into the study. ERI, a novel image processing technique, was accomplished by using super-resolution technology, and was assessed by objectively and subjectively comparing the image quality among three different image groups: images enlarged without bicubic interpolation (NONE), with bicubic interpolation (IP), and with ERI. Read More

    CFI-rs7356506 polymorphisms associated with Vogt-Koyanagi-Harada syndrome.
    Mol Vis 2016 14;22:9-17. Epub 2016 Jan 14.
    The Eye Hospital of Wenzhou Medical University, State Key Laboratory Cultivation Base and Key Laboratory of Vision Science, Ministry of Health, Wenzhou 325027, China.
    Purpose: Complement factor I (CFI) plays an important role in complement activation pathways and is known to affect the development of uveitis. The present study was performed to investigate the existence of an association between CFI genetic polymorphisms and Vogt-Koyanagi-Harada (VKH) syndrome.

    Methods: A total of 100 patients diagnosed with VKH syndrome and 300 healthy controls were recruited for the study. Read More

    Optical Intensities of Different Compartments of Subretinal Fluid in Acute Vogt-Koyanagi-Harada Disease.
    PLoS One 2016 12;11(2):e0149376. Epub 2016 Feb 12.
    Joint Shantou International Eye Center, Shantou University and the Chinese University of Hong Kong, Shantou, Guangdong, China.
    Purpose: To investigate the optical intensity in different compartments of subretinal fluid in acute Vogt-Koyanagi-Harada (VKH) disease by using spectral domain optical coherence tomography (SD-OCT).

    Methods: Fifty acute VKH eyes and 25 cases with acute central serous chorioretinopathy (CSCR) were included in this retrospective comparative study. The optical intensities of subretinal fluid, vitreous humour and the entire scanned region displayed by SD-OCT were measured with Image J by three independent readers. Read More

    Relative changes in luminal and stromal areas of choroid determined by binarization of EDI-OCT images in eyes with Vogt-Koyanagi-Harada disease after treatment.
    Graefes Arch Clin Exp Ophthalmol 2016 Mar 4;254(3):421-6. Epub 2016 Feb 4.
    Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan.
    Purpose: The aim of this study was to determine the changes in the luminal and stromal areas of the choroid in eyes with Vogt-Koyanagi-Harada disease by optical coherence tomography (OCT).

    Methods: A retrospective observational study. Choroidal images were recorded by enhanced depth imaging (EDI-OCT) at the baseline, and at 1 week and 1 month after initiating steroid therapy. Read More

    Decreased B and T lymphocyte attenuator in Behcet's disease may trigger abnormal Th17 and Th1 immune responses.
    Sci Rep 2016 Feb 4;6:20401. Epub 2016 Feb 4.
    The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Lab of Ophthalmology, Chongqing Eye Institute, Chongqing, P. R. China.
    Behcet's disease (BD) is a chronic, systemic and recurrent inflammatory disease associated with hyperactive Th17 and Th1 immune responses. Recent studies have shown that B and T lymphocyte attenuator (BTLA) negatively regulates the immune response. In this study, we investigated whether BTLA activation could be exploited to inhibit the development of abnormal immune responses in BD patients. Read More

    Indocyanine green angiographic findings in initial-onset acute Vogt-Koyanagi-Harada disease.
    Acta Ophthalmol 2016 Sep 29;94(6):573-8. Epub 2016 Jan 29.
    Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
    Purpose: To study the features of Indocyanine green angiography (ICGA) in patients with initial-onset acute Vogt-Koyanagi-Harada (VKH) disease.

    Methods: Retrospective cohort study of ICGA performed with the use of Heidelberg scanning laser ophthalmoscope on a consecutive series of patients with initial-onset acute VKH disease. The following signs were analysed: choroidal perfusion inhomogeneity, early hyperfluorescent stromal vessels, hypofluorescent dark dots (HDDs), fuzzy or lost pattern of large stromal choroidal vessels, disc hyperfluorescence, and, diffuse late choroidal hyperfluorescence. Read More

    miR-23a, miR-146a and miR-301a confer predisposition to Vogt-Koyanagi-Harada syndrome but not to Behcet's disease.
    Sci Rep 2016 Jan 28;6:20057. Epub 2016 Jan 28.
    The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
    Ninety-eight miRNAs are involved in the immune response. However, the genetic roles of these miRNAs remain unclear in Behcet's disease (BD) and Vogt-Koyanagi-Harada (VKH) syndrome. This study aimed to explore the association and functional roles of copy number variants (CNV) in several miRNAs with BD and VKH syndrome. Read More

    Two Genetic Variations in the IRF8 region are associated with Behçet's disease in Han Chinese.
    Sci Rep 2016 Jan 22;6:19651. Epub 2016 Jan 22.
    The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, P R China.
    Several modulatory factors in the TLR signaling pathway including IRF3, IRF7, IRF8, TRIM20, MYD88 and NF-κB1 have been associated with autoimmune disease. In this study, we investigated the association of 13 SNPs for these genes with Behçet's disease (BD) and Vogt-Koyanagi-Harada (VKH) syndrome using a polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay. Haplotype and linkage disequilibrium (LD) analysis were performed by Haploview4. Read More

    Association of ATG5 Gene Polymorphisms With Behçet's Disease and ATG10 Gene Polymorphisms With VKH Syndrome in a Chinese Han Population.
    Invest Ophthalmol Vis Sci 2015 Dec;56(13):8280-7
    The First Affiliated Hospital of Chongqing Medical University Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, People's Republic of China.
    Purpose: This study was conducted to explore the association of autophagy-related genes (ATGs) single nucleotide polymorphisms (SNPs) with Behçet's disease (BD) and Vogt-Koyanagi-Harada (VKH) syndrome in a Chinese Han population.

    Methods: A two-stage association study was carried out in 940 BD, 1061 VKH, and 2007 healthy controls. Genotyping for genetic variants of 10 autophagy family genes (ATG5, ATG7, ATG10, ATG16L1, IRGM, LKKR2, ATG2A, DAP, ULK1, and TSC1) was performed using PCR-restriction fragment length polymorphism (PCR-RFLP) or TaqMan SNP assays. Read More

    [Current status and future prospect of uveitis research in China].
    Zhonghua Yan Ke Za Zhi 2015 Oct;51(10):721-5
    The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, and Chongqing Eye Institute, Chongqing 400016, China; Email:
    Uveitis, as one of the major cause of blindness worldwide, seriously harms patients' vision and quality of life. The social and economic burden caused by uveitis cannot be ignored. Remarkable achievements in basic and clinical uveitis research were gained after decades of unremitting efforts by Chinese ophthalmologists. Read More

    Significant role of the choroidal outer layer during recovery from choroidal thickening in Vogt-Koyanagi-Harada disease patients treated with systemic corticosteroids.
    BMC Ophthalmol 2015 Dec 18;15:181. Epub 2015 Dec 18.
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
    Background: Which of the choroidal layers suffers the most extensive morphological changes during the course of Vogt-Koyanagi-Harada (VKH) disease is still unknown. The aim of this study was to investigate the relationship between total thickness and the thickness of inner or outer layers in the choroid during systemic corticosteroid therapy in patients with VKH disease.

    Methods: This retrospective case series included 15 eyes of 10 patients with treatment-naïve VKH disease (4 men and 6 women; mean age, 41. Read More

    Association of the C2-CFB locus with non-infectious uveitis, specifically predisposed to Vogt-Koyanagi-Harada disease.
    Immunol Res 2016 Apr;64(2):610-8
    Eye Hospital, First Affiliated Hospital of Harbin Medical University, 23 Post Road, Nangang Region, Harbin, 150001, Heilongjiang, China.
    Complement component 2 (C2) and factor B (CFB) are regulators of complement system and involved in the alternative pathway, which have been identified to be associated with multiple immune-related diseases. This study aimed to investigate the association of these genes with non-infectious intermediate and posterior uveitis. A total of 260 Chinese non-infectious uveitis patients were recruited, including 97 patients with Vogt-Koyanagi-Harada disease (VKH), 70 patients with intermediate uveitis (IU) and 93 patients with Behçet's disease (BD). Read More

    Comparison of the Clinical Manifestations between Acute Vogt-Koyanagi-Harada Disease and Acute Bilateral Central Serous Chorioretinopathy.
    Korean J Ophthalmol 2015 Dec 25;29(6):389-95. Epub 2015 Nov 25.
    Siloam Eye Hospital, Seoul, Korea.
    Purpose: To compare clinical, angiographic, and optical coherence tomographic characteristics between eyes with acute Vogt-Koyanagi-Harada (VKH) disease and eyes with acute bilateral central serous chorioretinopathy (CSC), and to demonstrate distinguishing features between the two diseases in confusing cases.

    Methods: The medical records of 35 patients with VKH disease and 25 patients with bilateral CSC were retrospectively reviewed. Characteristics according to slit-lamp biomicroscopy, ophthalmoscopy, fundus photography, fluorescein angiography, indocyanine green angiography, and spectral-domain optical coherence tomography were compared between the two diseases. Read More

    Investigation of the association of Vogt-Koyanagi-Harada syndrome with IL23R-C1orf141 in Han Chinese Singaporean and ADO-ZNF365-EGR2 in Thai.
    Br J Ophthalmol 2016 Mar 1;100(3):436-42. Epub 2015 Dec 1.
    Department of Ophthalmology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China Chongqing Eye Institute, Chongqing, P. R. China Chongqing Key Laboratory of Ophthalmology, Chongqing, P. R. China.
    Background: We performed a multistage genome-wide association study of Vogt-Koyanagi-Harada (VKH) syndrome in a Han Chinese population and identified two novel non-human leukocyte antigen candidate regions previously. The aim of the study was to replicate the association of IL23R-C1orf141 and ADO-ZNF365-EGR2 with VKH syndrome in four sets of multinational populations in Asia.

    Method: We conducted a candidate genes association study involving 185 patients with VKH syndrome and 287 normal controls from Han Chinese Singaporeans, non-Han Chinese, Thais and Koreans. Read More

    [Management of uveomeningitis in internal medicine: Proposal for a diagnostic work-up].
    Rev Med Interne 2016 Jan 2;37(1):25-34. Epub 2015 Nov 2.
    Service de médecine interne, hôpital de la Croix-Rousse, hospices civils de Lyon, université de Lyon, 69317 Lyon cedex 04, France.
    Uveomeningitis relates to an inflammatory state extending from iris and ciliary bodies to the choroid behind the eye. Because of a close contact between eye and brain, and barrier disruption, the inflammation can spread into the central nervous system (CNS). We review the clinical manifestations of uveitis, which are known to provide helpful clues to the diagnosis and describe the infectious, inflammatory, and neoplastic conditions classically associated with the uveomeningitis. Read More

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