1,487 results match your criteria Vogt-Koyanagi-Harada Syndrome


Nivolumab-induced Vogt-Koyanagi-Harada-like Syndrome and Adrenocortical Insufficiency with Long-term Survival in a Patient with Non-small-cell Lung Cancer: A Case Report.

Intern Med 2021 Jun 5. Epub 2021 Jun 5.

Department of Pulmonology, Yokohama City University Graduate School of Medicine, Japan.

A 58-year-old man was diagnosed with lung adenocarcinoma with a tumor proportion score of 10%. After six cycles of second-line chemotherapy with nivolumab, he achieved a complete response (CR) but developed uveitis and sensorineural hearing disorder, which were consistent with Vogt-Koyanagi-Harada (VKH)-like syndrome. Simultaneously, pituitary adrenocortical insufficiency was identified. Read More

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Classification of Non-Infectious and/or Immune Mediated Choroiditis: A Brief Overview of the Essentials.

Diagnostics (Basel) 2021 May 24;11(6). Epub 2021 May 24.

Retinal and Inflammatory Eye Diseases, Centre for Ophthalmic Specialized Care (COS), Clinic Montchoisi Teaching Centre, 1003 Lausanne, Switzerland.

The choroid was poorly accessible to imaging investigation until the last decade of the last century. With the availability of more precise imaging methods such as indocyanine green angiography (ICGA) and, later, optical coherence tomography (OCT), enhanced depth OCT (EDI-OCT), and OCT angiography (OCTA), appraisal of choroidal inflammation has substantially gained in accuracy. This allowed to precisely determine which structures were touched in the different non-infectious choroiditis entities and made it possible to classify this group of diseases, ICGA signs, mainly hypofluorescent lesions, were identified and described. Read More

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Incidence and changing patterns of uveitis in Central Tokyo.

Int Ophthalmol 2021 May 28. Epub 2021 May 28.

Department of Ophthalmology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Purpose: The patterns of uveitis in Tokyo have recently changed due to advances in examination tools. We aimed to investigate the changes in the patterns of uveitis between 2004-2015 and 2016-2018.

Methods: We retrospectively reviewed the data of 732 patients who visited the Uveitis Clinic at the University of Tokyo Hospital between January 2016 and December 2018. Read More

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Immune Phenotyping of Patients With Acute Vogt-Koyanagi-Harada Syndrome Before and After Glucocorticoids Therapy.

Front Immunol 2021 28;12:659150. Epub 2021 Apr 28.

Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Previous studies have established that disturbed lymphocytes are involved in the pathogenesis of Vogt-Koyanagi-Harada (VKH) syndrome. Accordingly, glucocorticoids (GCs), with their well-recognized immune-suppressive function, have been widely used for treatment of VKH patients with acute relapses. However, the systemic response of diverse immune cells to GC therapy in VKH is poorly characterized. Read More

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Vogt-Koyanagi-Harada-like syndrome in the setting of combined anti-PD1/anti-CTLA4 therapy.

Clin Exp Dermatol 2021 Apr 13. Epub 2021 Apr 13.

Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

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[Abnormal eyelashes and eyebrows].

Rev Med Interne 2021 Apr 7. Epub 2021 Apr 7.

Service de dermatologie, hôpital universitaire Hedi Chaker, Elain Road, KM0.5, 3003 Sfax, Tunisie.

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Delayed diagnosis of myelitis in a patient with Vogt-Koyanagi-Harada disease: a case report.

J Int Med Res 2021 Mar;49(3):3000605211001633

Department of Physical Medicine and Rehabilitation, Spine Centre, College of Medicine, Yeungnam University, Daegu, Republic of Korea.

A case of myelitis following Vogt-Koyanagi-Harada (VKH) disease is reported, in which diagnosis and treatment were delayed. A 43-year-old male patient diagnosed with VKH disease presented at the Spine Centre of Yeungnam University Hospital, Daegu, Republic of Korea, with motor weakness, sensory deficit in both lower extremities, and dysuria for the previous 3 months. VKH disease had been diagnosed 15 months previously, based on vision loss in both eyes and the presence of bilateral nontraumatic granulomatous iridocyclitis, exudates, and retinal oedema. Read More

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Acute lymphocytic leukemia with initial manifestation of serous retinal detachment and choroidal thickening: case report and literature review.

J Int Med Res 2021 Mar;49(3):300060520964373

Department of Ophthalmology, The 900th Hospital of Joint Logistic Support Force, PLA (Clinical Medical College of Fujian Medical University, Dongfang Hopsital Affiliated to Xiamen University), Fuzhou, China.

This report describes a patient who had acute lymphocytic leukemia with exudative retinal detachment (RD), which mimicked Vogt-Koyanagi-Harada disease (VKH). A 61-year-old woman presented with painless loss of vision in the left eye. Fundus examination revealed RD in her left eye. Read More

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Epidemiology of uveitis in Japan: a 2016 retrospective nationwide survey.

Jpn J Ophthalmol 2021 Mar 11;65(2):184-190. Epub 2021 Mar 11.

Department of Ophthalmology, Tokyo Medical University Hospital, Tokyo, Japan.

Purpose: To investigate the epidemiology of uveitis in Japan and assess its changes over time.

Study Design: Retrospective multicenter study METHODS: Sixty-six hospitals in Japan with uveitis specialty clinics participated in this retrospective nationwide survey. A questionnaire was sent to each hospital to survey the total number of patients who made a first visit to the outpatient uveitis clinic of each hospital between 1 April 2016 and 31 March 2017. Read More

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Ponatinib Inducing a Panuveitis with Choroidal Effusions and Neurosensory Retinal Detachment in a Patient with Chronic Myeloid Leukaemia.

Ocul Immunol Inflamm 2021 Mar 4:1-4. Epub 2021 Mar 4.

Ophthalmology Department, Leeds Teaching Hospitals, Leeds, UK.

Case Summary: We present the case of a 50 year old male patient being treated for chronic myeloid leukemia by the tyrosine kinase inhibitor, Ponatinib. After 3 months of treatment, he developed a sight-threatening granulomatous panuveitis in both eyes, with choroidal effusions and neurosensory retinal detachments. Except for a positive interferon-gamma release assay suggesting previous Tuberculosis exposure, all uveitis investigations were normal. Read More

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Peripheral Blood Transcriptome in Patients with Sarcoidosis-Associated Uveitis.

Ocul Immunol Inflamm 2021 Mar 4:1-4. Epub 2021 Mar 4.

Francis I. Proctor Foundation, University of California, San Francisco, California, USA.

: To identify peripheral blood transcriptome differences in uveitis patients with sarcoidosis compared to those with Vogt-Koyanagi-Harada (VKH) syndrome and controls.: Ten patients with uveitis compatible with sarcoidosis (eight with pulmonary sarcoidosis, one with central nervous system sarcoidosis, and one with conjunctival sarcoidosis), nine patients with VKH, and nine healthy controls were prospectively enrolled.: Ten genes exhibited a four-fold difference in expression in sarcoidosis patients compared to controls, many being involved in regulating inflammatory processes or cellular responses to microbes. Read More

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Vogt-Koyanagi-Harada Syndrome in a Canadian First Nations Population.

Ocul Immunol Inflamm 2021 Feb 23:1-7. Epub 2021 Feb 23.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Canada.

: To characterize presentations, characteristics and outcomes of uveitis in Vogt-Koyanagi-Harada (VKH) syndrome in a North American First Nations (FN) population.: Charts of 27 Canadian FN patients with VKH uveitis were retrospectively reviewed to characterize demographics, disease characteristics, management, complications and visual outcomes.: Average age at uveitis onset was 30. Read More

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February 2021

Comparing the Results of Vitrectomy and Sclerectomy in a Patient with Nanophthalmic Uveal Effusion Syndrome.

Medicina (Kaunas) 2021 Jan 29;57(2). Epub 2021 Jan 29.

Department of Ophthalmology, Faculty of Medicine, Comenius University, 82101 Bratislava, Slovakia.

Nanophthalmic uveal effusion syndrome (UES) is an extremely rare idiopathic disease characterized by a short axial length of the eye, extremely thick sclera and choroid. These structural changes can lead to spontaneous serous detachment of the retina and peripheral choroid. There are many other causes of UES such as trauma, inflammation, cataract surgery, glaucoma, or retinal detachment. Read More

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January 2021

Delayed-onset unilateral Vogt-Koyanagi-Harada syndrome: a multimodal imaging appraisal.

BMJ Case Rep 2021 Feb 10;14(2). Epub 2021 Feb 10.

Dr. RP Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India

A 38-year-old woman who had previously been diagnosed and treated for unilateral Vogt-Koyanagi-Harada syndrome (VKH) and had undergone multiple intravitreal bevacizumab injections to manage inflammatory choroidal neovascularisation in her right eye, presented 2 years later with visual complains in left eye. Clinical examination, fluorescein angiography, indocyanine green angiography (ICGA) and enhanced depth imaging optical coherence tomography (EDI-OCT) assisted evaluation confirmed active inflammation of left eye along with absence of any inflammation in the right eye. Unilateral active inflammation can be seen in the setting of VKH. Read More

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February 2021

[Autofluorescence combined with spectral domain optical coherence tomography for diagnosis and follow-up of acute Vogt-Koyanagi-Harada disease].

Nan Fang Yi Ke Da Xue Xue Bao 2021 Jan;41(1):135-140

Department of Ophthalmology, Second Affiliated Hospital of Xi' an Jiaotong University, Xi'an 710000, China.

Objective: To evaluate the value of fundus autofluorescence (FAF) imaging combined with spectral domain optical coherence tomography (SD-OCT) in diagnosis, prognostic assessment and follow-up observation of acute Vogt-KoyanagiHarada (VKH) disease.

Methods: Clinical data were collected from 12 patients (23 eyes) with acute VKH disease treated in our hospital from May, 2018 to November, 2019, including detailed medical history, best corrected visual acuity (BCVA), and results of slit lamp biomicroscopy, fundus photography, SD-OCT, fundus fluorescein angiography (FFA) and FAF imaging.SDOCT and FAF imaging were repeated after a course of treatment and in follow-up examination, and the results were compared with those at the time of admission. Read More

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January 2021

Vogt-Koyanagi-Harada Disease and Systemic Lupus Erythematosus Occurring during Adalimumab Therapy for Ulcerative Colitis.

Middle East Afr J Ophthalmol 2020 Jul-Sep;27(3):185-187. Epub 2020 Oct 30.

Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

We report the case of a 36-year-old male patient known to have ulcerative colitis on adalimumab treatment for 2 years who presented with initial-onset acute uveitis associated with Vogt-Koyanagi-Harada disease. Uveitis was treated successfully with systemic corticosteroids combined with mycophenolate mofetil. The patient had complete resolution of posterior segment inflammation and exudative retinal detachment. Read More

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January 2021

Case Series: Gene Expression Analysis in Canine Vogt-Koyanagi-Harada/Uveodermatologic Syndrome and Vitiligo Reveals Conserved Immunopathogenesis Pathways Between Dog and Human Autoimmune Pigmentary Disorders.

Front Immunol 2020 15;11:590558. Epub 2020 Dec 15.

Department of Dermatology, UMass Medical School, Worcester, MA, United States.

Vogt-Koyanagi-Harada syndrome (VKH) and vitiligo are autoimmune diseases that target melanocytes. VKH affects several organs such as the skin, hair follicle, eyes, ears, and meninges, whereas vitiligo is often limited to the skin and mucosa. Many studies have identified immune genes, pathways and cells that drive the pathogeneses of VKH and vitiligo, including interleukins, chemokines, cytotoxic T-cells, and other leukocytes. Read More

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December 2020

Proliferative retinopathy as a feature of Vogt Koyanagi Harada Disease: a report of two cases.

BMC Ophthalmol 2020 Dec 1;20(1):470. Epub 2020 Dec 1.

Vitreoretinal Division, King Khaled Eye Specialist Hospital, Al- Oruba Street, PO Box 7191, Riyadh, 11462, Kingdom of Saudi Arabia.

Background: Proliferative retinopathy is an uncommon feature of Vogt Koyanagi Harada (VKH) disease which might indicate poor uveitis control in these patients. We aim to describe the clinical features and outcome of management of proliferative retinopathy in 2 patients with VKH.

Case Presentation: 19 and 33 years old females with VKH presented with unilateral proliferative retinopathy. Read More

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December 2020

Audiological findings in the Vogt-Koyanagi-Harada Syndrome.

Codas 2020 9;32(5):e20190183. Epub 2020 Nov 9.

Faculdade de Odontologia de Bauru (FOB)- Universidade de São Paulo, Bauru, SP, Brazil.

The Vogt-Koyanagi-Harada syndrome (VKHS) is a rare, multisystemic and autoimmune disease. The syndrome mainly affects the eyes, followed by bilateral chronic panuveitis, however, the syndrome may also affect the melanocytes tissues, for example, the eyes, inner ear, meninges and skin. The syndrome origin mechanism is not yet completely known. Read More

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November 2020

Predictive Biomarker for Progression Into the Sunset Glow Fundus of Vogt-Koyanagi-Harada Disease, Using Adaptive Binarization of Fundus Photographs.

Transl Vis Sci Technol 2020 10 9;9(11):10. Epub 2020 Oct 9.

Department of Ophthalmology, Hyogo College of Medicine, Hyogo, Japan.

Purpose: The sunset glow fundus (SGF) appearance in Vogt-Koyanagi-Harada (VKH) disease was evaluated by means of adaptive binarization of patients' fundus photographs.

Methods: Twenty-nine Japanese patients with acute VKH were enrolled in this study. We evaluated one eye of each patient, and thereby divided the patients into two groups; SGF+ and SGF- at 6 months after treatment. Read More

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October 2020

Associations between functional and structural measurements in non-acute Vogt-Koyanagi-Harada disease.

Acta Ophthalmol 2020 Oct 30. Epub 2020 Oct 30.

Department of Ophthalmology, LIM-33, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.

Purpose: To evaluate associations between functional and structural measurements in patients with non-acute VKHD.

Methods: In this cross-sectional study, 16 non-acute VKHD patients (32 eyes; 14 female) were evaluated with multifocal electroretinogram (mfERG), standardized automated perimetry (SAP) and optical coherence tomography (OCT)examinations. All included patients had a minimum 12 months of follow-up from acute onset and were participants of an ongoing prospective study since acute phase with systematic clinical imaging evaluations and electroretinogram examinations within a predefined treatment. Read More

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October 2020

Clinical Features of Japanese Patients with Ocular Inflammation and Their Surgical Procedures Over the Course of 20 Years.

Clin Ophthalmol 2020 24;14:2799-2806. Epub 2020 Sep 24.

Department of Ophthalmology, Osaka Medical College, Takatsuki, Japan.

Purpose: To review clinical characteristics of ocular inflammation patients in Osaka, Japan, over 20 years and investigate the efficacy of required surgeries.

Methods: We conducted a retrospective study involving 2730 eyes of 1815 patients with ocular inflammation examined at the Osaka Medical College Hospital from April 1999 to March 2019.

Results: Patients comprised 843 males and 972 females, with a mean age of 56. Read More

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September 2020

Vogt-Koyanagi-Harada: treatment of recurrence after administration of 3 intravenous bolus of 1g of corticosteroids and mycophenolate mofetil.

Arch Soc Esp Oftalmol (Engl Ed) 2020 Oct 6. Epub 2020 Oct 6.

Servicio de Oftalmología, Hospital Universitari i Politècnic La Fe, Valencia, España.

The case is presented on a young Honduran female with no medical history of note, who presented with multiple areas of exudative retinal detachment (RD), and a best-corrected visual acuity of 1.3logMAR in both eyes. She was diagnosed with incomplete Vogt-Koyanagi-Harada syndrome, and treated early with a combination of intravenous therapy with 1g of prednisolone per day for 3 days, as recommended by published evidence, as well as mycophenolate mofetil (2g per day). Read More

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October 2020

Vogt-Koyanagi-Harada disease: a retrospective and multicentric study of 41 patients.

BMC Ophthalmol 2020 Oct 7;20(1):395. Epub 2020 Oct 7.

Department of Internal Medicine, Nancy University Hospital, Nancy, France.

Background: East and South East Asian subjects as well as Amerindians and Hispanic subjects are predominantly affected by Vogt-Koyanagi-Harada disease. In Europe, only few studies have described the clinical features and treatment of this disease, especially in France.

Methods: This retrospective case series was based on data collected from patients with a VKH disease diagnosed from January 2000 to March 2017, provided by three French Tertiary Centers. Read More

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October 2020

Risk factors for subretinal fibrosis in patients with Vogt Koyanagi Harada syndrome.

Ocul Immunol Inflamm 2020 Oct 6:1-5. Epub 2020 Oct 6.

Ocular Inflammatory Diseases Clinic, Hospital Dr. Luis Sánchez Bulnes, Asociación Para Evitar La Ceguera En México, Mexico City, Mexico.

To identify the risk factors for the development of subretinal fibrosis (SRF) among patients with Vogt-Koyanagi-Harada (VKH) syndrome. In this case-control study, electronic clinical records from patients diagnosed with VKH syndrome who attended the Inflammatory Eye Disease Clinic at a tertiary care ophthalmology reference center were assessed to identify risk factors from demographic, clinical, and epidemiological variables. Cases were defined as SRF and VKH, whereas the controls were VKH patients without SRF. Read More

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October 2020

Acute Lymphoblastic Leukemia Presenting as Acute Vogt-Koyanagi-Harada Syndrome.

Case Rep Ophthalmol 2020 May-Aug;11(2):481-485. Epub 2020 Aug 11.

Retina and Vitreous Service, Nikookari Eye Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.

We aimed to describe a case of acute lymphoblastic leukemia (ALL) that initially presented and was managed as Vogt-Koyanagi-Harada syndrome (VKH). A 62-year-old man was referred for vision loss starting 1 week ago. There was no prior systemic or ocular history. Read More

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A case of Vogt-Koyanagi-Harada-like uveitis secondary to dabrafenib/trametinib therapy for advanced melanoma.

Eur J Ophthalmol 2020 Oct 1:1120672120962044. Epub 2020 Oct 1.

Department of Ophthalmology, San Raffaele Scientific Institute, University Vita-Salute, Milan, Italy.

We report a case of ocular drug toxicity consistent with bilateral Vogt-Koyanagi-Harada (VKH) like disease in a patient with cutaneous melanoma treated with Dabrafenib/Trametinib therapy. A 53-year-old man with a history of metastatic cutaneous melanoma, treated with Dabrafenib/Trametinib, developed a severe acute panuveitis with granulomatous anterior uveitis and multiple serous retinal detachments. The ocular inflammatory reaction was classified as a bilateral Vogt-Koyanagi-Harada disease. Read More

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October 2020

Genetic landscape and autoimmunity of monocytes in developing Vogt-Koyanagi-Harada disease.

Proc Natl Acad Sci U S A 2020 10 28;117(41):25712-25721. Epub 2020 Sep 28.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, Sun Yat-sen University, 510060 Guangzhou, China;

Vogt-Koyanagi-Harada (VKH) disease is a systemic autoimmune disorder affecting multiple organs, including eyes, skin, and central nervous system. It is known that monocytes significantly contribute to the development of autoimmune disease. However, the subset heterogeneity with unique functions and signatures in human circulating monocytes and the identity of disease-specific monocytic populations remain largely unknown. Read More

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October 2020