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    1230 results match your criteria Vogt-Koyanagi-Harada Syndrome

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    Association between CD40 rs1883832 and immune-related diseases susceptibility: a meta-analysis.
    Oncotarget 2017 Jun 28. Epub 2017 Jun 28.
    Department of Urology Surgery, The First Affliated Hospital of Xiamen University, Center of Diagnosis and Treatment of Urinary System Diseases, The First Affliated Hospital of Xiamen University, The Key Laboratory of Urinary Tract Tumors and Calculi of Xiamen City, The First Affliated Hospital of Xiamen University, Xiamen, Fujian, 361003, China.
    Background/objective: It has been reported that CD40 rs1883832 might be associated with immune-related diseases susceptibility. Owing to mixed and inconclusive results, we conducted a meta-analysis of case-control studies to summarize and clarify this association.Methods/main results: A systematic search of studies on the association between CD40 rs1883832 and immune-related diseases susceptibility was conducted in databases. Read More

    [The fundus manifestations and SD-OCT findings of patients with acute Vogt-Koyanagi-Harada disease].
    Zhonghua Yan Ke Za Zhi 2017 Jun;53(6):436-439
    Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences Beijing 100730, China.
    Objective: To conclude the characteristics of fundus appearance and spectral domain optical coherence tomography(SD-OCT) findings of patients with acute Vogt-Koyanagi-Harada (VKH) disease. Methods: The clinical data of 17 patients (34 eyes) diagnosed of acute VKH in Peking Union Medical College Hospital from Jan. 2012 to Dec. Read More

    Management of a rare presentation of Vogt-Koyanagi-Harada disease in human immunodeficiency virus/acquired immunodeficiency disease syndrome patient.
    Indian J Ophthalmol 2017 May;65(5):413-416
    Department of Uvea and Ocular Pathology, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India.
    Vogt-Koyanagi-Harada (VKH), a multisystem autoimmune bilateral panuveitis with systemic manifestations, is uncommon in immunocompromised patients such as human immunodeficiency virus (HIV)/acquired immunodeficiency disease syndrome (AIDS). We report a rare presentation of VKH in a 45-year-old HIV-positive female on highly active antiretroviral therapy (HAART) who presented with a history of recurrent panuveitis. A diagnosis of probable VKH was made based on ocular and systemic signs and symptoms. Read More

    Evaluation of the Glucocorticoid Receptor as a Biomarker of Treatment Response in Vogt-Koyanagi-Harada Disease.
    Invest Ophthalmol Vis Sci 2017 Feb;58(2):974-980
    Physiology Program, School of Medicine, Universidad de Chile, Santiago, Chile 4Rheumatology Service, Department of Medicine, Hospital Clinico Universidad de Chile, Santiago, Chile.
    Purpose: This study is aimed to investigate the role of glucocorticoid receptor (GR) isoforms in peripheral blood mononuclear cells (PBMC) as biomarkers of glucocorticoid (GC) resistance and to validate a set of clinical predictive factors in patients with Vogt-Koyanagi-Harada (VKH) disease.

    Methods: This was a prospective cohort study that included a total of 21 patients with VKH. A complete ophthalmologic evaluation was carried out at baseline that recorded the presence of any clinical predictive factors (visual acuity ≤ 20/200, tinnitus, chronic disease, and fundus depigmentation). Read More

    [Clinical features, risk factors and progresses on treatment of recurrent Vogt-Koyanagi-Harada disease].
    Zhonghua Yan Ke Za Zhi 2017 Apr;53(4):317-320
    Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
    Vogt-Koyanagi-Harada disease(VKH) is a bilateral, granulomatous panuveitis associated with central nervous system, auditory, and integumentary manifestations. Clinically, VKH usually responds well to early aggressive glucocorticosteroid treatment and may be cured without any clinically significant sequelae. Some patients, however, may enter the chronic recurrent phase, which may result in marked loss of vision due to complications such as complicated cataract, secondary glaucoma and maculopathy. Read More

    A challenged case of Vogt-Koyanagi-Harada syndrome: when dermatological manifestations came first.
    Int Ophthalmol 2017 Mar 30. Epub 2017 Mar 30.
    Hospital Prof Doutor Fernando Fonseca, Lisbon, Portugal.
    Introduction: Vogt-Koyanagi-Harada syndrome (VKHS) is an inflammatory systemic autoimmune disease principally affecting pigmented tissues in the ocular, auditory, integumentary and central nervous systems. Patients are generally women in the fourth decade of life. The prognosis is correlated mainly with the time between diagnosis and the start of treatment and number of recurrent episodes of inflammation. Read More

    Multi-modal imaging and anatomic classification of the white dot syndromes.
    Int J Retina Vitreous 2017 20;3:12. Epub 2017 Mar 20.
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, 600 Highland Ave, Madison, WI 53705 USA.
    The white dot syndromes (WDS) are a diverse group of posterior uveitidies that share similar clinical findings but are unique from one another. Multimodal imaging has allowed us to better understand the morphology, the activity and age of lesions, and whether there is CNV associated with these different ocular pathologies. The "white dot syndromes" and their uveitic masqueraders can now be anatomically categorized based on lesion localization. Read More

    Vogt Koyanagi Harada Syndrome mimicking multiple sclerosis: A case report and review of the literature.
    Mult Scler Relat Disord 2017 Feb 6;12:44-48. Epub 2017 Jan 6.
    Najran University, Najran, Saudi Arabia.
    Vogt Koyanagi Harada (VKH) Syndrome, also called uveomeningioencephalitis, is a chronic disorder characterized by inflammation of the uvea, meninges, auditory system, and integumentary system. The association between VKH syndrome and multiple sclerosis (MS) has been reported only once in the literature in a patient who developed VKH syndrome after two years of the diagnosis of MS. In this article, we report a case who was misdiagnosed and treated as MS until she was proven to have VKH syndrome, and a diagnosis of MS was excluded. Read More

    Promoter Hypermethylation of GATA3, IL-4, and TGF-β Confers Susceptibility to Vogt-Koyanagi-Harada Disease in Han Chinese.
    Invest Ophthalmol Vis Sci 2017 Mar;58(3):1529-1536
    The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, China.
    Purpose: We investigated the role of promoter methylation of transcriptional and inflammatory factors, including TBX21, GATA3, RORγt, FOXP3, IFN-γ, IL-4, IL-17A, and TGF-β in the development of Vogt-Koyanagi-Harada (VKH) disease.

    Methods: The promoter methylation levels were detected by the Sequenom MassARRAY system in CD4+ T cells that were separated from 20 healthy individuals and 32 VKH patients (20 in the active stage without medication, 12 in inactive stage with medication). The mRNA expression level of GATA3, IL-4, and TGF-β in CD4+ T cells was analyzed by real-time RT-PCR. Read More

    Vogt-Koyanagi-Harada-like Syndrome Complicating Pembrolizumab Treatment for Metastatic Melanoma.
    J Immunother 2017 Feb/Mar;40(2):77-82
    Departments of *Ophthalmology †Dermatology, LYON SUD Hospital Center, Hospices Civils of Lyon, Pierre Bénite Cedex Departments of ‡Internal Medicine §Ophthalmology, Croix-Rousse Hospital, Hospices Civils of Lyon, Lyon, France.
    Vogt-Koyanagi-Harada (VKH) syndrome is a rare condition implicating systemic immune reaction against melanocytes. The pathophysiology is unclear. A genetic predisposition has been suggested as HLA-DR4/DRB1*04 is more common among VKH patients. Read More

    Distinguishing features of acute Vogt-Koyanagi-Harada disease and acute central serous chorioretinopathy on optical coherence tomography angiography and en face optical coherence tomography imaging.
    J Ophthalmic Inflamm Infect 2017 Dec 13;7(1). Epub 2017 Jan 13.
    Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India.
    Background: The aim of this study is to determine the differences in optical coherence tomography angiography (OCTA) features of acute Vogt-Koyanagi-Harada disease (VKH) and acute central serous chorioretinopathy (CSC). Clinical and imaging data of patients with acute CSC and VKH in a tertiary-care institute were analyzed. Multimodal imaging including fluorescein angiography, indocyanine green angiography (ICGA), and enhanced-depth imaging OCT were performed. Read More

    Vogt-Koyanagi-Harada syndrome (uveomeningoencephalitic syndrome).
    Eur J Ophthalmol 2017 Jan 19;27(1):e5-e8. Epub 2017 Jan 19.
    Department of Ophthalmology, Central Military University Hospital, Prague - Czech Republic.
    Purpose: To report a case of a 29-year-old man who was examined at the Eye Clinic of Central Military University Hospital Prague for a severe headache and acute blurring of vision in both eyes diagnosed as incomplete Vogt-Koyanagi-Harada syndrome (VKH).

    Methods: This is a retrospective and descriptive case report based on data from clinical records, patient observation and follow-ups and analysis of acquired diagnostic tests.

    Results: A 29-year-old man presented with headache and decreased vision in his left eye (LE) for 2 days. Read More

    [Vogt-Koyanagi-Harada Syndrome : An unusual case with lacquer crack-like retinal findings].
    Ophthalmologe 2016 Dec 22. Epub 2016 Dec 22.
    Augenklinik, Universitätsklinikum Dokuz Eylul, Izmir, Türkei.
    We report the case of a 35-year-old female patient with bilateral and recurrent panuveitis. Diagnosed with Vogt-Koyanagi-Harada syndrome, the patient was treated with corticosteroids, achieving rapid improvement of functional and morphological findings. After recovery of the exudative retinal detachment, peripapillary lacquer crack-like findings were observed. Read More

    Vogt-Koyanagi-Harada syndrome - current perspectives.
    Clin Ophthalmol 2016 24;10:2345-2361. Epub 2016 Nov 24.
    Uveitis Service, Moorfields Eye Hospital, London, UK; Department of Clinical Ophthalmology, UCL Institute of Ophthalmology, London, UK; Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel.
    Vogt-Koyanagi-Harada syndrome is a cause of noninfectious panuveitis, leading to significant vision loss in many patients. It is an autoimmune disease occurring in genetically susceptible individuals and clinically presents as bilateral panuveitis with serous retinal detachments and hyperemic, swollen optic discs, which are associated with neurological and auditory manifestations. Early diagnosis and prompt and adequate treatment with immunosuppressive agents (corticosteroids and other immunosuppressive drugs) may halt disease progression and prevent recurrences and vision loss. Read More

    A Rare Case of Unilateral Progressive Vision Loss and Pachymeningitis.
    Neuroophthalmology 2016 Oct 11;40(5):237-242. Epub 2016 Aug 11.
    Department of Neurology, University of Illinois College of Medicine, Peoria, Peoria, Illinois, USA; Illinois Neurologic Institute, Peoria, Illinois, USA.
    We describe a 32-year-old man with presumed Vogt-Koyanagi Harada (VKH) syndrome, whose presenting symptoms were headache and progressive loss of vision in the right eye. Neuro-ophthalmic examination showed anterior and posterior uveitis, and retinal detachment in the right eye. Ocular coherence tomography (OCT) showed extensive submacular fluid in the right eye, while the fundus fluorescein angiogram (FFA) confirmed perifoveal retinal pigment epithelium (RPE) disruption and multifocal fluorescein leakage in the right eye. Read More

    Managing macular hole associated with acute inflammatory Vogt-Koyanagi-Harada syndrome.
    Int J Retina Vitreous 2015 3;1:18. Epub 2015 Nov 3.
    Vitreoretinal Diseases Unit, Brazilian Institute of Fighting Against Blindness, São Paulo, Brazil.
    We report a 24-year-old man with Vogt-Koyanagi-Harada (VKH) syndrome who developed a macular hole (MH) during the acute inflammatory stage. Spontaneous resolution was unlikely because of the MH dimensions and absence of vitreous adherence. The patient underwent pars plana vitrectomy (PPV) and internal limiting membrane peeling during the acute stage followed by retinopexy with octafluoropropane injection and prone positioning for 5 days. Read More

    Enhanced Depth SD-OCT Images Reveal Characteristic Choroidal Changes in Patients With Vogt-Koyanagi-Harada Disease.
    Ophthalmic Surg Lasers Imaging Retina 2016 Nov;47(11):1004-1012
    Background And Objective: To identify characteristic choroidal changes of patients with Vogt-Koyanagi-Harada (VKH) disease at different stages.

    Patients And Methods: Fifty-four patients with VKH in the acute uveitic or convalescent stages, 24 patients with central serous chorioretinopathy (CSC), and 54 normal participants were enrolled in this prospective, observational study. Enhanced depth imaging spectral-domain optical coherence tomography scans were captured for all subjects to allow for comparison of choroidal morphological findings. Read More

    Retina 2016 Nov;36(11):2124-2131
    *Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea; †Department of Ophthalmology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Gangwon-do, Korea; ‡Department of Ophthalmology, Northwestern University School of Medicine, Chicago, IL; and §Ocular Imaging Research and Reading Center, Omaha, NE.
    Purpose: To investigate the efficacy and safety of fluocinolone acetonide intravitreal implant in patients with Vogt-Koyanagi-Harada disease.

    Methods: A post hoc, subgroup analysis on patients with Vogt-Koyanagi-Harada was performed using data sets from two multicenter randomized trials on fluocinolone acetonide implant. Each subject received fluocinolone acetonide implantation in one eye and standard-of-care treatment in the fellow eye and was followed for 3 years. Read More

    Retina 2016 Nov;36(11):2116-2123
    *Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Lab, Beijing, China; and †Department of Ophthalmology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany.
    Background/purpose: To examine the diagnostic value of optical coherence tomography (OCT) for the detection of acute Vogt-Koyanagi-Harada (VKH) disease.

    Methods: Clinical charts and OCT images were retrospectively reviewed for patients consecutively diagnosed with acute VKH, subacute VKH, multifocal central serous chorioretinopathy (CSCR), and posterior scleritis. All patients underwent OCT, fundus photography, and fluorescein angiography (FA) before treatment. Read More

    Choroidal circulation impairment during the anterior recurrence of Vogt-Koyanagi-Harada disease confirmed with indocyanine green angiography and laser speckle flowgraphy.
    Acta Ophthalmol 2016 Nov 15;94(7):e629-e636. Epub 2016 Apr 15.
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
    Purpose: To assess choroidal inflammation-related circulatory changes associated with the anterior recurrence of Vogt-Koyanagi-Harada (VKH) disease, using indocyanine green angiography (ICGA) and laser speckle flowgraphy (LSFG).

    Methods: This retrospective case series included 17 eyes of 11 patients with VKH disease showing recurrent inflammatory findings in the anterior, but not posterior, segment (i.e. Read More

    Sequence analysis of four vitamin D family genes (VDR, CYP24A1, CYP27B1 and CYP2R1) in Vogt-Koyanagi-Harada (VKH) patients: identification of a potentially pathogenic variant in CYP2R1.
    BMC Ophthalmol 2016 Oct 4;16(1):172. Epub 2016 Oct 4.
    Center for Genetics and Inherited Diseases, Taibah University Almadinah Almunawarah, Medina, 30001, Kingdom of Saudi Arabia.
    Background: VKH is a rare autoimmune disease. Decreased level of vitamin D has recently been found to be involved in the pathogenesis of Vogt-Koyanagi-Harada (VKH) disease. This study was designed to screen the vitamin D pathway genes for pathogenic mutations, if any, in VKH patients. Read More

    Personality and uveitis.
    J Ophthalmic Inflamm Infect 2016 Dec 6;6(1):36. Epub 2016 Oct 6.
    Cataract and Refractive Department, Narayana Nethralaya, Bangalore, India.
    Background: Psycho-immunology is an emerging branch of science which studies the interaction between the brain and the immune system. The purpose of this study is to identify the types of personality factors in patients with non-infectious uveitis and to find its association with a particular uveitic entity if any. This is a prospective, observational, case-control study of 186 patients with non-infectious uveitis (group A) and controls from general ophthalmology outpatient department (group B). Read More

    Contralateral Autologous Corneal Transplantation Experience in Mexico City.
    Cornea 2017 Jan;36(1):32-36
    Cornea and Refractive Surgery Division, Asociación Para Evitar la Ceguera, Universidad Nacional Autónoma de México, Mexico City, Mexico.
    Purpose: The aim of this study is to expand the limited knowledge regarding autologous contralateral penetrating keratoplasty.

    Methods: We report the retrospective outcomes of patients who received autokeratoplasty and contralateral opaque corneas in the donor eye at a tertiary care ophthalmology hospital in Mexico City.

    Results: Eleven patients received autokeratoplasty and contralateral opaque corneas in the donor eye at our center from 2010 to 2015. Read More

    A case of unilateral and spontaneously resolving posterior uveitis with overlapping features of Vogt-Koyanagi-Harada disease and Acute Posterior Multifocal Placoid Pigment Epitheliopathy.
    Springerplus 2016 1;5(1):1471. Epub 2016 Sep 1.
    Ivey Eye Institute, Western University, London, ON Canada.
    Introduction: VKH disease is a chronic, bilateral, granulomatous panuveitis with potential involvement of neurological, auditory and integumentary systems. On the other hand, APMPPE is believed to be an immune-driven chorioretinal vascular disease characterized by multifocal, flat, grey-white placoid lesions at the level of the RPE. We describe a case with overlapping figures of both conditions. Read More

    [Epidemiologic profile of uveitis: about 105 cases].
    Pan Afr Med J 2016 27;24:97. Epub 2016 May 27.
    Service d'Ophtalmologie à l'Hôpital Militaire d'Instruction Mohamed V de Rabat, Rabat, Maroc.
    The multiplicity of causes of uveitis makes diagnosis difficult. Determining epidemiological factors associated with uveitis allows better diagnostic orientation and facilitates therapeutic management. This is a retrospective study spanning four years from January 2012 to December 2015. Read More

    Topical difluprednate for treatment of serous retinal detachment and panuveitis associated with Vogt-Koyanagi-Harada disease.
    Digit J Ophthalmol 2016 28;22(2):54-7. Epub 2016 Jun 28.
    Macula Retina Vitreous Center, Torrance, California.
    Patients with bilateral serous retinal detachments and panuveitis related to Vogt-Koyanagi-Harada disease are commonly managed with oral corticosteroids, immunosuppressive agents, and/or intravitreal injections. We present the case of a 56-year-old Hispanic man with Harada disease whose bilateral serous retinal detachments and panuveitis were treated with topical corticosteroid difluprednate alone. Functional and anatomical recoveries were assessed by fluorescein angiograms and optical coherence tomography studies over a period of 9 months. Read More

    Mycophenolate mofetil combined with systemic corticosteroids prevents progression to chronic recurrent inflammation and development of 'sunset glow fundus' in initial-onset acute uveitis associated with Vogt-Koyanagi-Harada disease.
    Acta Ophthalmol 2017 Feb 18;95(1):85-90. Epub 2016 Aug 18.
    Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
    Purpose: To evaluate the effectiveness and safety of mycophenolate mofetil (MMF) as first-line therapy combined with systemic corticosteroids in initial-onset acute uveitis associated with Vogt-Koyanagi-Harada (VKH) disease.

    Methods: This prospective study included 38 patients (76 eyes). The main outcome measures were final visual acuity, corticosteroid-sparing effect, progression to chronic recurrent granulomatous uveitis and development of complications, particularly 'sunset glow fundus'. Read More

    Patterns and Etiologies of Uveitis at a Tertiary Referral Center in Taiwan.
    Ocul Immunol Inflamm 2016 Jul 27:1-8. Epub 2016 Jul 27.
    a Department of Ophthalmology , Kaohsiung Veterans General Hospital , Kaohsiung , Taiwan and.
    Purpose: To analyze the patterns and etiologies of uveitis at a tertiary referral center in Taiwan.

    Methods: This retrospective chart review of uveitis patients from January 2001 to December 2014 updates a previous study a decade ago (2003).

    Results: We identified 450 patients, among whom anterior uveitis was most common, followed by panuveitis, posterior uveitis, and intermediate uveitis. Read More

    The Role of Optical Coherence Tomography Angiography in the Diagnosis and Management of Acute Vogt-Koyanagi-Harada Disease.
    Ocul Immunol Inflamm 2016 Jul 20:1-12. Epub 2016 Jul 20.
    a Advanced Eye Center , Post Graduate Institute of Medical Education and Research , Chandigarh , India.
    Purpose: To report the imaging characteristics of acute Vogt-Koyanagi-Harada (VKH) disease using optical coherence tomography angiography (OCTA).

    Methods: In this prospective study, patients with acute VKH (n = 10; mean age: 30.5 ± 13. Read More

    The Relationship of Vogt-Koyanagi-Harada Syndrome to Ocular Hypertension and Glaucoma.
    Ocul Immunol Inflamm 2016 Jul 20:1-5. Epub 2016 Jul 20.
    a Department of Ophthalmology , Duke University Medical Center , Durham , North Carolina , USA.
    Purpose: Vogt-Koyanagi-Harada (VKH) syndrome is a systemic inflammatory autoimmune disease with associated ophthalmic pathology. Glaucoma has been reported in patients with VKH. The purpose of this report is to examine the frequency and types of glaucoma associated with VKH. Read More

    [Vogt-Koyanagi-Harada syndrome].
    Rev Fac Cien Med Univ Nac Cordoba 2016 ;73(2):132-3
    Instituto de Oftalmología "Conde de Valenciana", México DF, México.
    The Vogt-Koyanagi-Harada syndrome is a disease with dermatological, neurologic and auditory findings, associated with a bilateral granulomatous panuveitis. We present the case of a 42-year-old woman who started with ophthalmic manifestations, and in a late follow-up she developed the characteristic dermatological findings. Read More

    Extremely early stage osteonecrosis of the femoral head in a patient with hip pain secondary systemic steroid pulse therapy for Vogt-Koyanagi-Harada syndrome: A case report.
    Int J Surg Case Rep 2016 15;25:97-101. Epub 2016 Jun 15.
    Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Shogoin, Kawahara-cho 54, Sakyo-ku, Kyoto 606-8507, Japan.
    Introduction: Osteonecrosis of the femoral head (ONFH) is a corticosteroid-associated disease that mostly cause femoral head collapse and gait disturbance. At the final stage of ONFH, the most reliable treatment is total hip arthroplasty even in young patients. Although magnetic resonance imaging (MRI) is useful for early diagnosis, initial stages are asymptomatic, with pain intensifying after femoral head collapse. Read More

    Outcomes of Vogt-Koyanagi-Harada Disease: A Subanalysis From a Randomized Clinical Trial of Antimetabolite Therapies.
    Am J Ophthalmol 2016 Aug 10;168:279-86. Epub 2016 Jun 10.
    F.I. Proctor Foundation, University of California San Francisco, San Francisco, California; Department of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, California; Department of Ophthalmology, University of California San Francisco, San Francisco, California. Electronic address:
    Purpose: To report outcomes of Vogt-Koyanagi-Harada (VKH) disease from a clinical trial of antimetabolite therapies.

    Design: Subanalysis from an observer-masked randomized clinical trial for noninfectious intermediate, posterior, and panuveitis.

    Methods: setting: Clinical practice at Aravind Eye Hospitals, India. Read More

    Vogt-Koyanagi-Harada disease.
    Surv Ophthalmol 2017 Jan - Feb;62(1):1-25. Epub 2016 May 27.
    USC Roski Eye Institute, Los Angeles, California, USA.
    Vogt-Koyanagi-Harada disease, a severe bilateral granulomatous intraocular inflammation associated with serous retinal detachments, disk edema, and vitritis, with eventual development of a sunset glow fundus, is an autoimmune inflammatory condition mediated by T cells that target melanocytes in individuals susceptible to the disease. Vogt-Koyanagi-Harada disease presents clinically in 4 different phases: prodromal, uveitic, convalescent, and recurrent, with extraocular manifestations including headache, meningismus, hearing loss, poliosis, and vitiligo, to varying degrees. There have been considerable advances in imaging modalities resulting in earlier diagnosis and improved understanding of this disease. Read More

    Association of Vogt Koyanagi Harada Syndrome and Seronegative Rheumatoid Arthritis.
    Ethiop J Health Sci 2016 Mar;26(2):193-6
    Bezm-i Alem Foundation University School Of Medicine, Department Of Physical Therapy And Rehabilitation, Istanbul.
    Background: Vogt Koyanagi Harada (VKH) Syndrome is a rarely-seen multi-systemic, autoimmune and inflammatory disease. It observed frequently with neurologic, auditory and skin manifestations and characterized with bilateral, chronic and diffused granulomatous panuveitis. It generally affects women in young-adult period. Read More

    Cutaneous manifestations associated with melanoma.
    Semin Oncol 2016 Jun 23;43(3):384-9. Epub 2016 Feb 23.
    Department of Dermatology, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH. Electronic address:
    Melanoma is a malignancy most commonly arising from the skin; therefore, primary melanoma characteristics are usually the first cutaneous manifestations of melanoma. Cutaneous metastases, which can occur locally or diffusely, are important to detect in a timely manner as treatments for advanced melanoma that impact survival are now available. Melanoma can be associated with local or diffuse pigmentation changes, including depigmentation associated with the leukodermas and hyperpigmentation associated with diffuse melanosis cutis. Read More

    Ocular and orbital side-effects of checkpoint inhibitors: a review article.
    Curr Opin Oncol 2016 Jul;28(4):288-94
    aSaint Joseph University, Faculty of Medicine, Beirut, Lebanon bFondation ophtalmologique Adolphe de Rothschild cHôpital Bichat Claude Bernard, Faculté de Médecine Diderot Paris 7, France.
    Purpose Of Review: Checkpoint inhibitors have been increasingly considered as new targets for cancer therapies. Patients receiving checkpoint inhibitors develop many immune-related adverse events (IRAEs). However, ophthalmic IRAEs are rare and have been reported in less than 1% of patients. Read More

    Association of a NOS3 gene polymorphism with Behçet's disease but not with Vogt-Koyanagi-Harada syndrome in Han Chinese.
    Mol Vis 2016 3;22:311-8. Epub 2016 Apr 3.
    The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, P. R. China.
    Purpose: Previous studies have identified that nitric oxide synthase (NOS) genes are associated with several immune-mediated diseases. This study aimed to investigate whether NOS2 and NOS3 gene polymorphisms are associated with Behçet's disease (BD) and Vogt-Koyanagi-Harada (VKH) syndrome in a Han Chinese population.

    Methods: An association analysis of NOS2/rs4795067, NOS3/rs1799983 and NOS3/rs1800779 was performed in 733 patients with BD, 800 patients with VKH syndrome, and 1,359 controls using PCR restriction fragment length polymorphism (PCR-RFLP) assay. Read More

    Autoimmunity in visual loss.
    Handb Clin Neurol 2016 ;133:353-76
    Moorfields Eye Hospital, The National Hospital for Neurology and Neurosurgery and St. Thomas' Hospital, London, UK. Electronic address:
    There are a number of autoimmune disorders which can affect visual function. There are a very large number of mechanisms in the visual pathway which could potentially be the targets of autoimmune attack. In practice it is the retina and the anterior visual pathway (optic nerve and chiasm) that are recognised as being affected in autoimmune disorders. Read More

    Long-term Outcomes of Limited Vogt-Koyanagi-Harada Syndrome.
    Am J Ophthalmol 2016 Jul 8;167:52-6. Epub 2016 Apr 8.
    Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital and Ophthalmology, Department of Surgery, University of Melbourne, East Melbourne, Australia; Royal Victorian Eye and Ear Hospital, East Melbourne, Australia. Electronic address:
    Purpose: To describe the long-term outcomes of patients with limited Vogt-Koyanagi Harada syndrome (VKH), characterized by steroid-responsive serous retinal detachments without other signs of intraocular inflammation.

    Design: Retrospective case series.

    Methods: Consecutive patients from the Royal Victorian Eye and Ear Hospital with acute bilateral serous retinal detachments without anterior chamber inflammation, with no previous ocular history or trauma, and with negative screening for vasculitis and other systemic autoimmune disease were included. Read More

    Vogt-Koyanagi-Harada syndrome: Perspectives for immunogenetics, multimodal imaging, and therapeutic options.
    Autoimmun Rev 2016 Aug 7;15(8):809-19. Epub 2016 Apr 7.
    Massachusetts Eye Research and Surgery Institution, 1440 Main Street, Suite 20, Waltham, MA 02451, USA; Ocular Immunology and Uveitis Foundation, Waltham, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address:
    Vogt-Koyanagi-Harada syndrome (VKH) is a bilateral, diffuse granulomatous uveitis associated with neurological, audiovestibular, and dermatological systems. The primary pathogenesis is T-cell-mediated autoimmune response directed towards melanocyte or melanocyte-associated antigens causing inflammation of the choroidal layer. This phenomenon usually leads to diffuse inflammatory conditions throughout most parts of eye before ocular complications ensue. Read More

    The role of enhanced depth imaging optical coherence tomography in chronic Vogt-Koyanagi-Harada disease.
    Br J Ophthalmol 2017 Feb 5;101(2):186-189. Epub 2016 Apr 5.
    Singapore National Eye Centre, Singapore, Singapore.
    Aims: To determine the role of enhanced depth imaging optical coherence tomography (EDI-OCT) in chronic Vogt-Koyanagi-Harada (VKH) disease.

    Methods: Records of all consecutive patients with VKH seen at the Singapore National Eye Centre were retrospectively reviewed for concurrent EDI-OCT and indocyanine green angiograms (ICGAs) obtained six or more months after disease onset, demographics and duration of disease. The ICGAs were scored based on the following signs: early choroidal stromal vessel hyperfluorescence and leakage, hypofluorescent dark dots, fuzzy vascular pattern of large stromal vessels and disc hyperfluorescence, and correlated with the subfoveal choroidal thickness (SFCT) measured using EDI-OCT. Read More

    Vogt-Koyanagi-Harada disease: review of a rare autoimmune disease targeting antigens of melanocytes.
    Orphanet J Rare Dis 2016 Mar 24;11:29. Epub 2016 Mar 24.
    Uveitis Service, Department of Ophthalmology, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, Rua Diana, 863 apto 91J, 05019-000, São Paulo, Brazil.
    Vogt-Koyanagi-Harada disease (VKHD) is a rare granulomatous inflammatory disease that affects pigmented structures, such as eye, inner ear, meninges, skin and hair. This disease is mainly a Th1 lymphocyte mediated aggression to melanocytes after a viral trigger in the presence of HLA-DRB1*0405 allele. The absence of ocular trauma or previous intraocular surgery sets VKHD appart from sympathetic ophthalmia, its main differential diagnosis. Read More

    Higher Expression of NOD1 and NOD2 is Associated with Vogt-Koyanagi-Harada (VKH) Syndrome But Not Behcet's Disease (BD).
    Curr Mol Med 2016 ;16(4):424-35
    First Affiliated Hospital of Chongqing Medical University, Youyi Road 1, Chongqing 400016, P.R. China.
    NOD1 and NOD2 have been found to play a significant regulatory role in autoimmune disease. To analyze the role of NOD1 and NOD2 in the pathogenesis of Vogt- Koyanagi-Harada (VKH) syndrome and Behcet's disease (BD). We analyzed the expression of NOD1 and NOD2 from PBMCs by RT-PCR and Western Blot. Read More

    Frequency of Uveitis in the Central Tokyo Area (2010-2012).
    Ocul Immunol Inflamm 2016 Mar 8:1-7. Epub 2016 Mar 8.
    b Department of Ophthalmology , Japan Community Healthcare Organization Tokyo Shinjuku Medical Center , Shinjuku-ku , Tokyo , Japan.
    Purpose: To investigate the frequency of conditions of newly arrived patients with uveitis from 2010 to 2012 and compare this frequency with that since 2004.

    Methods: We retrospectively analyzed clinical records of patients who visited the outpatient clinic from January 2010 to December 2012, and compared them with those from 2004-2009.

    Results: From 2010 to 2012, 695 new patients with uveitis visited Tokyo University Hospital, with a definite diagnosis made in 431 (62. Read More

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