Search Our Scientific Publications & Authors

Cureus 2022 May 23;14(5):e25261. Epub 2022 May 23.

Internal Medicine, HCA Florida Orange Park Hospital, Orange Park, USA.

Hypothyroidism is a commonly encountered pathology within internal medicine. It commonly presents with symptoms of fatigue, weight gain, constipation, and dry skin. Long-standing uncontrolled hypothyroidism can manifest with atypical symptoms of dysphonia and even pericardial effusion. Read More

Laryngoscope 2022 Jun 22. Epub 2022 Jun 22.

Department of Otolaryngology, Children's National Health System, Washington, District of Columbia, USA.

Objective: To explore patient-reported outcome measures of pediatric paradoxical vocal fold motion through a multi-institutional study of geographically diverse United States medical facilities to assess long-term management and outcomes.

Methods: Eligible participants >8 years of age diagnosed with PVFM over a 10-year period from 7 tertiary pediatric hospitals were invited to complete a survey addressing study objectives.

Results: 65 participants completed the survey, of whom 80% were female, 75% reported a 3. Read More

Indian J Crit Care Med 2022 Feb;26(2):167-173

Department of ENT, Christian Medical College, Vellore, Tamil Nadu, India.

Background: Organophosphorus (OP) and carbamate pesticides are widely used for crop protection. We describe the spectrum of laryngeal abnormalities in patients admitted to the intensive care unit (ICU) with acute OP and carbamate poisoning as there is limited information on it.

Materials And Methods: Consecutive patients admitted to the ICU with acute OP and carbamate poisoning over 20 months (December 2014-July 2016) were recruited. Read More

J Thorac Cardiovasc Surg 2022 May 16. Epub 2022 May 16.

Division of Cardiovascular Critical Care, Department of Cardiology, Boston Children's Hospital, Boston, Mass; Department of Pediatrics, Harvard Medical School, Boston, Mass.

Objective: Feeding strategies in infants with hypoplastic left heart syndrome (HLHS) following stage 1 palliation (S1P) include feeding tube utilization (FTU). Timely identification of infants who will fail oral feeding could mitigate morbidity in this vulnerable population. We aimed to develop a novel clinical risk prediction score for FTU. Read More

Am J Respir Crit Care Med 2022 Jun 1. Epub 2022 Jun 1.

University of Iowa, 4083, Internal Medicine, Iowa City, Iowa, United States;

Front Surg 2022 4;9:882594. Epub 2022 May 4.

Sarasota Memorial Health Care System Multidisciplinary Thyroid and Parathyroid Center, Sarasota, Florida, United States.

The field of endocrine surgery has expanded from the traditional open neck approach to include remote access techniques as well as minimally invasive approaches for benign and malignant thyroid nodules. In experienced hands and with careful patient selection, each approach is considered safe, however complications can and do exist. Post-operative dysphonia can have serious consequences to the patient by affecting quality of life and ability to function at work and in daily life. Read More

Int J Pediatr Otorhinolaryngol 2022 Jul 14;158:111182. Epub 2022 May 14.

Department of Surgery, University of Wisconsin, Madison, United States. Electronic address:

Purpose: Paradoxical Vocal Fold Movement (PVFM) may cause airway restriction and resulting dyspnea in the pediatric population. Therapy with a speech-language pathologist (SLP) is the primary treatment for children and adolescents diagnosed with Paradoxical Vocal Fold Movement (PVFM). This study examined treatment duration and factors predicting number of therapy sessions required. Read More

Int J Pediatr Otorhinolaryngol 2022 Jul 13;158:111142. Epub 2022 May 13.

Hospices Civils de Lyon, Service d'ORL Pédiatrique, Hôpital Femme Mère Enfants, Bron Cedex, F-69500, France.

Introduction: Laryngeal mobility disorder after a pediatric heart surgery is common (between 5 and 10% of cases), and has important consequences on swallowing, breathing and speaking. After reviewing the literature, the recovery rate is variable and the postoperative follow-up is often done on a short time frame. The primary objective of the study is to describe the recovery from laryngeal mobility disorder with a follow-up time of at least 5 years. Read More

HNO 2022 May 16. Epub 2022 May 16.

Heidelberger Institut für Global Health, Universität Heidelberg, Heidelberg, Deutschland.

Background: By today's standard, the optimal treatment of every individual tumor patient is discussed and determined in an interdisciplinary tumor board. According to the new S3 guidelines, larger volume T3 laryngeal cancers which are no longer safely resectable with larynx-sparing surgery are ideal candidates for a larynx preservation approach using primary chemoradiation (pCRT). So far, no clear criteria have been defined under what circumstances primary radiotherapy alone (pRT) might be acceptable in case chemotherapy (CT) is prohibited or in what cases, even in T3, upfront total laryngectomy with risk-adapted adjuvant treatment (TL±a[C]RT) should be recommended. Read More

Am Fam Physician 2022 May;105(5):462

Respirology 2022 May 4. Epub 2022 May 4.

School of Clinical Sciences, Monash Health & University, Melbourne, Victoria, Australia.

Cancer Diagn Progn 2021 Jul-Aug;1(3):143-149. Epub 2021 Jul 3.

Department of Radiation Oncology, SS. Annunziata Hospital, "G. D'Annunzio" University of Chieti, Chieti, Italy.

Background/aim: We employed a multimodal evaluation of voice outcome (MEVO) model to assess long-term voice outcome in early glottic cancer (EGC) patients treated with primary radiotherapy (RT). The model consisted of objective and subjective vocal evaluation during follow-up, by a dedicated Speech Pathologist and Speech Therapist.

Patients And Methods: MEVO methodology includes Self-perception Voice Handicap Index (VHI-30), evaluation of parameters Grade (G), Roughness (R), Breathiness (B), Asthenia (A) and Strain (S) according to GRBAS scale, objective analysis and aerodynamics using the PRAAT software and laryngeal evaluation with videostroboscope (VS). Read More

J Clin Endocrinol Metab 2022 Jun;107(7):e2762-e2769

Department of Visceral, Thoracic and Vascular Surgery, Section of Endocrine Surgery, Philipps-University Marburg, Marburg, Germany.

Objective: The impact of heavier weight of resected thyroid specimen on postoperative morbidity after total thyroidectomy for multinodular benign goiter remains unclear.

Methods: Data from the prospective StuDoQ|Thyroid registry of the German Society of General and Visceral Surgery were analyzed regarding the weight of the resected thyroid specimen and perioperative morbidity (vocal cord palsy, hemorrhage, surgical site infection, and hypocalcemia). To achieve a homogeneous patient population, only patients with total thyroidectomy for multinodular benign goiter were included. Read More

Pediatr Pulmonol 2022 06 22;57(6):1401-1415. Epub 2022 Apr 22.

Department of Pediatrics, University of Alberta, Edmonton, Canada.

Inducible laryngeal obstruction (ILO) in children is underrecognized. This systematic review characterizes the scientific evidence on the impact of pediatric ILO diagnosis and treatment on asthma medication use. This review, registered with PROSPERO (CRD42020209168), utilized database searches in MEDLINE, EMBASE, CINAHL, and Web of Science from inception to October 2020. Read More

Am J Surg 2022 Jul 19;224(1 Pt B):400-407. Epub 2022 Mar 19.

Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA. Electronic address:

Background: Management of asymptomatic primary hyperparathyroidism (PHPT) in older patients (age >50) is controversial. The 4th International Workshop on the Management of Asymptomatic PHPT recommends surveillance for older patients who lack objective signs of disease, whereas The American Association of Endocrine Surgeons (AAES) guidelines recommend consideration of parathyroidectomy for patients of any age with subjective constitutional, neuropsychiatric, or cognitive symptoms. Therefore, the primary objective of this study was to evaluate the association between patient age and both practice patterns and outcomes in the management of patients with sporadic PHPT. Read More

Vestn Otorinolaringol 2022 ;87(1):27-32

Regional Clinical Hospital No. 1, Tyumen, Russia.

Objective: To assess the diagnostic efficiency of transcutaneous laryngeal ultrasound.

Material And Methods: Ultrasound examination of the larynx and laryngoscopy was performed in 103 patients with thyroid disease. 26 (34. Read More

J Allergy Clin Immunol Pract 2022 05 5;10(5):1380-1381. Epub 2022 Mar 5.

Monash Lung Sleep Allergy and Immunology, Monash Health, Clayton, Victoria, Australia; School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.

Saudi Med J 2022 Mar;43(3):275-282

From the Department of Anaesthesiology and Reanimation (Pehlıvan, Gergın, Bayram, Biçer, Aksu); and from the Department of Pediatric Gastroenterology (Altay, Arslan), Medical Faculty, Erciyes University, Kayseri, Turkey.

Objectives: To investigate the rate of laryngospasm with sedation during the esophagogastroduodenoscopy (EGD) procedure in children exposed to passive smoking and to examine the frequency of complications due to laryngospasm.

Methods: A single-blind, prospective, observational study with a total of 518 patients evaluated according to the American Society of Anesthesiologists (ASA) physical status as classification I-II, aged between 1-18 years, and planned to undergo an EGD procedure, were included. Age, gender, weight, ASA assessment, exposure to smoking (the mother, the father, both parents were smokers, or not exposed to smoking), drug doses used in sedation, and anesthesia-related complications, such as cough, decrease in oxygen saturation, and laryngospasm were recorded. Read More

Laryngoscope 2022 Mar 3. Epub 2022 Mar 3.

Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, U.S.A.

Objective: Gastroesophageal reflux disease (GERD) and laryngopharyngeal reflux (LPR) are chronic conditions caused by backflow of gastric and duodenal contents into the esophagus and proximal aerodigestive tract, respectively. Mucosal barrier dysfunction resultant from the synergistic actions of chemical injury and the mucosal inflammatory response during reflux contributes to symptom perception. Alginates effectively treat symptoms of mild to moderate GERD and have recently shown benefit for LPR. Read More

Case Rep Surg 2022 21;2022:3147824. Epub 2022 Feb 21.

Department of Otolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan.

A nonrecurrent laryngeal nerve (NRLN) is a rare anatomical variant of laryngeal nerves that branches directly from the vagus nerve. The anatomical abnormality makes it difficult to identify the NRLN and results in high incidence of accidental nerve injury during surgery. A 76-year-old woman complained of swelling in the right side of her neck and visited our university hospital for further examination. Read More

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 Dec;46(12):1430-1436

Department of Pediatrics, Third Xiangya Hospital, Central South University, Changsha 410013, China.

Severe neonatal episodic laryngospasm (SNEL) is an ion channel disease characterized by recurrent life-threatening myotonia of respiratory muscle due to mutations in the voltage-gated sodium channel genes. Here we reported a newborn manifested as paroxysmal cyanosis and limb myotonia after birth. The neonate also developed muscle hypertrophy and stunted growth during the follow-up. Read More

Pediatr Emerg Care 2022 Mar;38(3):e1085-e1086

Abstract: Point-of-care ultrasound has been instrumental in allowing providers to make prompt diagnoses at the bedside but has been historically underutilized for the diagnosis of upper airway processes, including paradoxical vocal fold motion (PVFM), also known as vocal cord dysfunction. PVFM is characterized by adduction of the vocal cords during inspiration, resulting in stridor and shortness of breath. This case report describes a teenage girl who presented to the pediatric emergency department (ED) with difficulty breathing. Read More

Eur Heart J Case Rep 2022 Jan 10;6(1):ytac008. Epub 2022 Jan 10.

Division of Cardiology, Department of Internal Medicine, Ascension St. John Hospital and Medical Center (), 22101 Moross Road, Detroit, MI 48236, USA.

Background: We previously described percutaneous thrombectomy and right ventricular (RV) mechanical support of a coronavirus disease 2019 (COVID-19) patient with a massive pulmonary embolism. Here, we present a detailed echocardiographic and clinical timeline with 1-year follow-up.

Case Summary: A 57-year-old female with COVID-19 went into shock from a massive pulmonary embolism. Read More

Eur Ann Otorhinolaryngol Head Neck Dis 2022 Feb 8. Epub 2022 Feb 8.

Department of Otorhinolaryngology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, No. 1111 Xianxia Road, Shanghai 200336, China. Electronic address:

Objectives: In our study, we hypothesized that sternum-mental angle (SMA) was a totally new preoperative predictor of difficult laryngeal exposure (DLE). The main objective of this study was to evaluate the diagnostic utility of SMA in predicting DLE in patients undergoing suspension microlaryngeal surgery, and we also searched for risk factors among the selected parameters.

Methods: A total of 95 patients with vocal cord dysfunction who underwent microlaryngeal surgery were collected. Read More

Eur Respir Rev 2022 Mar 9;31(163). Epub 2022 Feb 9.

Woolcock Institute of Medical Research, The University of Sydney, Sydney, Australia.

Recently, "Technical standards for respiratory oscillometry" was published, which reviewed the physiological basis of oscillometric measures and detailed the technical factors related to equipment and test performance, quality assurance and reporting of results. Here we present a review of the clinical significance and applications of oscillometry. We briefly review the physiological principles of oscillometry and the basics of oscillometry interpretation, and then describe what is currently known about oscillometry in its role as a sensitive measure of airway resistance, bronchodilator responsiveness and bronchial challenge testing, and response to medical therapy, particularly in asthma and COPD. Read More

Scand J Med Sci Sports 2022 Jun 8;32(6):1041-1049. Epub 2022 Feb 8.

Department of Pediatric and Adolescent Medicine, Haukeland University Hospital, Bergen, Norway.

Purpose: Exercise-induced bronchoconstriction (EIB) and exercise-induced laryngeal obstruction (EILO) are the two disorders commonly considered when athletes complain of exertional dyspnea. They are highly different but often confused. We aimed to address this diagnostic challenge and its consequences in elite athletes. Read More

Muscle Nerve 2022 04 12;65(4):367-368. Epub 2022 Feb 12.

Department of Neurology, Penn State Health M.S. Hershey Medical Center, Hershey, Pennsylvania, USA.

Pneumologie 2022 Jun 25;76(6):414-418. Epub 2022 Jan 25.

Klinik für Innere Medizin, SP Pneumologie, Intensiv- und Schlafmedizin, Marburg.

We present the case of an otherwise healthy 19-year-old student who has been affected by vocal cord dysfuntion (VCD) since she is fourteen. 3 years after that diagnosis she has also been coughing blood at an increasing rate (1-3 times per week). We postulate that the haemoptoe is the result of breathing against a closed airway which can lead to excessively high negative intrathoracic pressures. Read More

Cell Transplant 2022 Jan-Dec;31:9636897211073136

Hospital for Endocrine Surgery, Tampa, FL, USA.

Recurrent laryngeal nerve (RLN) damage is a significant and prevalent complication of thyroid surgery. Based on the beneficial role of a human amnion/chorion membrane (HACM) allograft in wound management and nerve regeneration, we investigated whether placement of a commercially available HACM allograft on dissected RLN could reduce the occurrence and/or duration of RLN injury during thyroidectomy. Among 67 patients undergoing thyroidectomy, 100 at-risk nerves (exposure of at least 3 cm of RLN) received intraoperative placement of HACM; 205 at-risk RLNs without HACM in 134 matched patients served as controls. Read More

J Med Case Rep 2022 Jan 17;16(1). Epub 2022 Jan 17.

Medical Director of Academics, Clinical Research and Precision Medicine, Lee Physicians Group, Lee Health, 9800 S. HealthPark Drive, Suite 200, Fort Myers, FL, 33908, USA.

Background: Allergic rhinitis is the most common allergic disease encountered in a primary care setting. Diagnosis is often made clinically based on response to empiric therapy. However, with long-term treatment failure and/or atypical disease presentation, a differential diagnosis should be considered. Read More