34,470 results match your criteria Vitreous Hemorrhage
J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.
Department of Ophthalmology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China.
Objective: To study the mechanism of collapsin response mediator protein-2 (CRMP-2) phosphorylation changes and cyclin-dependent kinase 5 (CDK5) expression after optic nerve injury.
Methods: Optic nerve injury rat models were constructed, the messenger RNA (mRNA) level of CRMP-2 in optic nerve tissues was determined by quantitative reverse transcription polymerase chain reaction (qRT-PCR) after building models 0, 3, 7, and 14 days. The protein expression of CRMP-2, phospho-CRMP-2 (p-CRMP-2), and CDK5 were also determined by western blot analysis. Read More
Acta Ophthalmol 2018 Dec 7. Epub 2018 Dec 7.
Department of Vitreoretinal Surgery, The Rotterdam Eye Hospital, Rotterdam, the Netherlands.
Purpose: Unremoved vitreoschisis-induced vitreous cortex remnants (VCR) are associated with macular pathology. When present on the retinal periphery, they may play a role in proliferative vitreoretinopathy and retinal detachment after vitrectomy. Existing instruments for their removal involve substantial risk of iatrogenic retinal damage. Read More
J Mol Med (Berl) 2018 Dec 8. Epub 2018 Dec 8.
Buchanan Ocular Therapeutics Unit, Department of Ophthalmology and the New Zealand National Eye Centre, University of Auckland, Auckland, New Zealand.
Diabetic retinopathy (DR) is a vascular disease of the neuroretina characterised by hyperglycaemia and inflammation. Current DR therapies target late-stage vascular defects and there is evidence to suggest that they contribute to geographic atrophy and retinal ganglion cell death long term. Therefore, alternative treatments that target common upstream disease mechanisms are needed. Read More
Int J Retina Vitreous 2018 5;4:44. Epub 2018 Dec 5.
1Vitreous Retina Macula Consultants of New York, 460 Park Ave., New York, NY 10022 USA.
Background: Aneurysmal type 1 neovascularization (AT1) is a term recently introduced to better describe the aneurysmal dilatation that may arise from neovascular lesions, more commonly known as polypoidal choroidal vasculopathy. The proposed term, AT1, includes an expanded clinical spectrum of aneurysmal (polypoidal) lesions observed in both different ethnicities and associated with varied clinical phenotypes.
Case Presentation: A 61-year-old woman of European descent was referred for a new, asymptomatic retinal hemorrhage found on routine examination. Read More
PLoS One 2018 11;13(12):e0208980. Epub 2018 Dec 11.
Department of Ophthalmology, University Medical Center Goettingen, Germany.
Purpose: To investigate the feasibility and diagnostic benefit of routinely performed preoperative macular spectral-domain (SD-) optical coherence tomography (OCT) for the detection of macular pathology in patients with normal biomicroscopic funduscopy prior to cataract surgery.
Methods: Prospective, single center study. A total of 162 eyes of 123 consecutive patients referred for cataract surgery with a visual acuity better than 20/100, absence of macular symptoms such as metamorphopsia, no history of previous intravitreal procedures and a normal funduscopic appearance on biomicroscopy underwent an additional SD-OCT-examination prior to cataract surgery. Read More
Clin Ophthalmol 2018 14;12:2323-2329. Epub 2018 Nov 14.
Department of Ophthalmology, Toho University Sakura Medical Center, Shimoshizu, Sakura, Japan,
Purpose: To investigate the potential risk factors for neovascular glaucoma (NVG) after vitrectomy in eyes with proliferative diabetic retinopathy.
Subjects And Methods: In this retrospective, observational, comparative study, patients with proliferative diabetic retinopathy who underwent vitrectomy at Toho University Sakura Medical Center between December 2011 and November 2016 and who were followed for ≥12 months after surgery were included. Subject parameters examined included age, glycated hemoglobin (HbA1c), fasting blood glucose, administration of insulin, and estimated glomerular filtration rate. Read More
Retin Cases Brief Rep 2018 Nov 28. Epub 2018 Nov 28.
Department of Ophthalmology, Ministry of Education, Key Laboratory of Vision Loss and Restoration, Peking University Third Hospital, Beijing, China.
Purpose: Optic disk astrocytoma is a rare variant of congenital hamartoma, which is usually associated with tuberous sclerosis complex. Generally, it is stationary but in rare cases, it can show progressive growth and cause severe local complications.
Methods: Clinical-pathologic correlation. Read More
J Cataract Refract Surg 2018 Dec 7. Epub 2018 Dec 7.
From the Epsom and St. Helier University National Health Service Trust, London, United Kingdom.
Purpose: To compare iris hooks and a pupil expansion ring (Malyugin ring) in eyes with a small pupil.
Setting: Epsom and St. Helier University National Health Service Trust, London, United Kingdom. Read More
Zhonghua Yan Ke Za Zhi 2018 Dec;54(12):918-922
Tianjin Medical University Eye Hospital, College of Optometry and Ophthalmology, Tianjin Medical University Eye Institute, Tianjin 300384, China.
To report the clinical outcomes and safety profile of 27G(+) transconjunctival sutureless vitrectomy (TSV) in eyes with posterior segment disease. Prospective, interventional case series. Eyes undergoing 27G(+) TSV for a vitreoretinal surgery indication were included from Dec 2015 to Mar 2016. Read More
Stem Cells Dev 2018 Dec 10. Epub 2018 Dec 10.
Fudan University, Department of Anatomy, Histology and Embryology, Shanghai, China ;
Human embryonic stem cells (hESCs) have the potential to differentiate along the retinal lineage. We have efficiently differentiated human pluripotent stem cells (hPSCs) into optic cup-like structures by using a novel retinal differentiation medium (RDM).The purpose of this study was to determine whether the retinal progenitor cells (RPCs) derived from hESCs can integrate into the host retina and differentiate into retinal ganglion cells (RGCs) in vivo. Read More
Int J Retina Vitreous 2018 30;4:45. Epub 2018 Nov 30.
Gavin Herbert Eye Institute, University of California Irvine, 850 Health Sciences Road, Irvine, CA 92697 USA.
Background: Prader-Willi syndrome (PWS) is a genetic disease caused by loss of expression of the paternally inherited copy of several genes on the long arm of chromosome 15. Ophthalmic manifestations of PWS include strabismus, amblyopia, nystagmus, hypopigmentation of the iris and choroid, diabetic retinopathy, cataract and congenital ectropion uvea. An overlap between PWS and oculocutaneous albinism (OCA) has long been recognized and attributed to deletion of OCA2 gene located in PWS critical region (PWCR). Read More
Eye (Lond) 2018 Dec 5. Epub 2018 Dec 5.
Vitreous Retina Macula Consultants of New York, New York, NY, USA.
Objective: To explore the structural differences between X-linked retinoschisis (XLR) and stellate nonhereditary idiopathic foveomacular retinoschisis (SNIFR) using swept-source optical coherence tomography angiography (SS-OCTA).
Methods: A case series of two patients, a 9-year-old male with XLR and a 58-year-old woman with SNIFR were imaged with swept-source optical coherence tomography angiography (SS-OCTA; PLEX Elite 900, Carl Zeiss Meditec, Inc, Dublin, CA). Automated segmentation was manually adjusted to include the areas of retinoschisis within en face flow and structural slabs. Read More
Oman J Ophthalmol 2018 Sep-Dec;11(3):274-276
2nd Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, "Papageorgiou" General Hospital, 564 03 Thessaloniki, Macedonia, Greece.
We aim to present a case of bilateral rhegmatogenous retinal detachment (RRD) after successful phacoemulsification procedures performed 23 years before RRD onset and surgical management. A 57-year-old female presented with blurred vision due to floaters in the left eye. The patient was followed up with dilated fundus examination. Read More
J Coll Physicians Surg Pak 2018 Dec;28(12):919-922
Department of Ophthalmology, Mayo Hospital, Lahore, Pakistan.
Objective: To determine the changes in the retinal nerve fiber layer as measured on optical coherence tomography (OCT) after phacoemulsification with intraocular lens implantation.
Study Design: Quasi-experimental study.
Place And Duration Of Study: Department of Ophthalmology, Lahore General Hospital, Lahore, from March 2017 to April 2018. Read More
Ann Clin Biochem 2018 Dec 4:4563218820359. Epub 2018 Dec 4.
Qilu Hospital of Shandong University (Qingdao).
Objective: Adropin, a newly identified regulatory protein encoded by Enho gene, is correlated with insulin sensitivity and diabetes. The aim of this study is to determine whether serum and vitreous adropin concentrations are correlated with the presence of diabetic retinopathy (DR).
Methods: A population of 165 patients with type 2 diabetes mellitus (T2DM) [52 without DR, 69 with non-proliferative diabetic retinopathy (NPDR), and 44 patients with proliferative diabetic retinopathy (PDR)] was enrolled in this study. Read More
Am J Ophthalmol Case Rep 2019 Mar 11;13:41-45. Epub 2018 Nov 11.
Retina Department, Asociación para Evitar la Ceguera en México, Hospital "Dr. Luis Sánchez Bulnes" IAP, Mexico City, Mexico.
Purpose: To report a case of occlusive retinal vasculopathy, secondary to hyperhomocysteinemia.
Observations: A 43-year-old male was examined at the retina outpatient clinic due to complaints of bilateral decrease in visual acuity. The patient underwent a comprehensive ophthalmological examination, wide-field fundus photographs and fluorescein angiography, as well as spectral domain optical coherence tomography with enhanced-deep imaging. Read More
Arch Med Sadowej Kryminol 2018 ;68(2):108-118
Aim Of The Study: The aim of the study was to assess the suitability of vitreous humour (VH) for determining alcoholaemia in deceased bodies. The study presents a correlation between the content of ethyl alcohol in vitreous humour and the concentration of ethyl alcohol in venous blood (femoral blood - FB).
Material And Methods: The study material consisted of blood and vitreous humour samples taken from 62 individuals who died in the period 2012-2016 and whose post-mortem examinations were carried out at the Department of Forensic Medicine, Medical University of Bialystok. Read More
Vestn Oftalmol 2018 ;134(5. Vyp. 2):195-201
FH Aachen, Campus Jülich, 1 Heinrich-Mussmann-Str., Jülich, Germany, 52428.
Purpose: To compare the chemical elemental composition of vitreous cavity content taken from cadaveric eyes compared to samples taken from the eyes with terminal stage refractory glaucoma with decompensated intraocular pressure (IOP).
Material And Methods: The vitreous contents of the eyes from 2 groups were studied. The 1st group included 15 cadaveric eyes; the 2nd group included 15 eyes with refractory glaucoma in the terminal stage of the disease with decompensated IOP in patients with hypertension pain. Read More
Vestn Oftalmol 2018 ;134(5. Vyp. 2):156-161
I.M. Sechenov First Moscow Medical University, 8-2 Trubetskaya St., Moscow, Russian Federation, 119991.
Numerous studies have demonstrated the efficacy of anti-VEGF medications for exudative (wet) age-related macular degeneration (AMD). Significant IOP elevation is one of the side effects of anti-VEGF intravitreal injection.
Purpose: To study the changes in the parameters of anterior segment of the eyeball against acute IOP elevation after repeated intravitreal injections (IVI) of anti-VEGF medication. Read More
Semin Ophthalmol 2018 Nov 29:1-5. Epub 2018 Nov 29.
a Smt. Kanuri Santhamma Center for Vitreoretinal diseases, LV Prasad Eye Institute , Hyderabad , India.
Purpose: The purpose of the study is to report the prognostic factors and outcomes of vitrectomy (PPV) with silicone oil tamponade in rhegmatogenous retinal detachment (RRD) secondary to acute retinal necrosis (ARN).
Methods: This retrospective, non-randomized, interventional comparative study included 38 eyes of 38 patients. All cases underwent PPV with silicone oil tamponade. Read More
Retina 2018 Nov 21. Epub 2018 Nov 21.
Department of Ophthalmology, Hospital Universitari de Bellvitge, Barcelona, Spain.
Purpose: To investigate eyes with solitary large aneurysms arising from retinal capillaries.
Methods: Consecutive patients with aneurysms greater than 200 µm in diameter were evaluated with a comprehensive ophthalmologic examination including optical coherence tomography, optical coherence tomography angiography, and fluorescein angiography. The aneurysms were solitary in the sense, and there was only one aneurysm larger than the threshold diameter and a few or no other aneurysms. Read More
Community Eye Health 2018 ;31(103):65
Clinical Research fellow: London School of Hygiene and Tropical Medicine, London, UK.
Diagn Cytopathol 2018 Nov 28. Epub 2018 Nov 28.
Department of Pathology, Duke University Medical Center, Durham, North Carolina.
Background: Diagnostic vitrectomy with flow cytometry immunophenotyping (FCI) is being increasingly used as part of screening for diagnostically challenging cases. We aim to evaluate the utility of combined cytopathology and FCI in diagnostic pars plana vitrectomy. We also aim to evaluate cytologic features that could potentially predict FCI outcomes. Read More
Glia 2018 Nov 28. Epub 2018 Nov 28.
Department of Molecular Medicine, The Scripps Research Institute, California.
Ischemia-induced angiogenesis contributes to various neuronal and retinal diseases, and often results in neurodegeneration and visual impairment. Current treatments involve the use of anti-VEGF agents but are not successful in all cases. In this study we determined that miR-30a-5p is another important mediator of retinal angiogenesis. Read More
Case Rep Ophthalmol 2018 Sep-Dec;9(3):439-443. Epub 2018 Oct 18.
Asociación para Evitar la Ceguera en México, Hospital Dr. Luis Sanchez Bulnes, Mexico, Mexico.
In a newborn with candidemia, two retinal lesions were seen without external inflammatory signs or reaction in the anterior chamber or vitreous. However, handheld spectral domain-optical coherence tomography (HH SD-OCT) images show that one of the retinal lesions had a "firework display" projecting to the vitreous that was not identified in indirect ophthalmoscopy. This finding suggested a endophthalmitis. Read More
Case Rep Ophthalmol 2018 Sep-Dec;9(3):431-438. Epub 2018 Oct 11.
Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
Purpose: To report a modified surgical technique called the "donor tissue holding technique for Descemet's membrane endothelial keratoplasty (DMEK)" using a newly developed 25-gauge graft manipulator.
Methods: Six consecutive patients exhibiting endothelial dysfunction were enrolled and treated by DMEK. In brief, after insertion of a DMEK donor into the anterior chamber, the edge of the roll was grasped using a graft manipulator and this grasp was maintained throughout the centering and opening of the roll (holding technique). Read More
J West Afr Coll Surg 2017 Oct-Dec;7(4):72-84
Department of Ophthalmology, University of Ilorin Teaching Hospital, Ilorin, Nigeria.
Background: Corneal laceration is a partial or full thickness corneal injury resulting from direct or indirect ocular trauma. Cornea laceration generally leads to the development of corneal opacity which is a significant cause of blindness worldwide, particularly in developing countries where facility for corneal transplant is not readily available. Clinical outcomes depend on causes, the part of cornea involved, and availability of skilled human resource and presence of corneal transplant services. Read More
Adv Sci (Weinh) 2018 Nov 25;5(11):1800711. Epub 2018 Sep 25.
School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional Materials Tianjin University Tianjin 300350 China.
Recently, there has been a high expectation that high water absorbent hydrogels can be developed as an artificial vitreous body. However, the drawbacks associated with in vivo instability, biofouling, uncontrollable in situ reaction time, and injection-induced precrosslinked fragmentation preclude their genuine use as vitreous substitutes. Here, a supramolecular binary copolymer hydrogel termed as PNAGA-PCBAA by copolymerization of -acryloyl glycinamide (NAGA) and carboxybetaine acrylamide (CBAA) is prepared. Read More
Transl Vis Sci Technol 2018 Nov 14;7(6). Epub 2018 Nov 14.
Ruth & Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology and the Rappaport Institute, Haifa, Israel.
Purpose: To evaluate retinal toxicity of intravitreal trimethoprim-sulfamethoxazole (TMP-SMX) in an albino rabbit model.
Methods: Albino rabbits ( = 10) were treated in the right eye with the maximum intravitreal dose of TMP-SMX mixture (1600 μg/8000 μg /0.1 mL), while 0. Read More
Int J Retina Vitreous 2018 21;4:43. Epub 2018 Nov 21.
1Suita Tokushukai Hospital Eye Center, 21-1, Senriokanishi, Suita City, Osaka 565-0814 Japan.
Background: To report the multimodal imaging and histology of a case of metastatic esophageal cancer with vitreoretinal involvement resembling acute retinal necrosis (ARN) in a patient receiving systemic chemotherapy.
Case Presentation: A 69-year-old Japanese man with a history of stage 4 esophageal carcinoma, treated with three cycles of 5-fluorouracil (5-FU) and cisplatin (CDDP) chemotherapy as well as 30 sessions of radiation therapy, presented with new onset of blurry vision in the right eye (OD). Visual acuity was 20/200 OD. Read More
J Ophthalmic Vis Res 2018 Oct-Dec;13(4):504-507
Department of Ophthalmology, Mission Nethralaya, Shillong, Meghalaya, India.
Purpose: To report three cases of endophthalmitis following uneventful phacoemulsification surgery.
Case Report: Three cases presented with blurriness of vision 2 to 3 weeks following phacoemulsification. Vitreous culture confirmed the diagnosis. Read More
J Venom Anim Toxins Incl Trop Dis 2018 21;24:31. Epub 2018 Nov 21.
1Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av Antônio Carlos, 6627, 2nd Floor, Room 2031, Pampulha, Belo Horizonte, Minas Gerais 31270-901 Brazil.
Background: The great diversity of molecules found in spider venoms include amino acids, polyamines, proteins and peptides, among others. Some of these compounds can interact with different neuronal receptors and ion channels including those present in the ocular system. To study potential toxicity and safety of intravitreal injection in rabbits of LyeTx I b, a synthetic peptide derived from the toxin LyeTx I found in venom from the spider and to evaluate the angiogenic activity on a CAM model. Read More
Semin Ophthalmol 2018 Nov 26:1-5. Epub 2018 Nov 26.
a Smt. Kanuri Santhamma Retina Vitreous Centre , L V Prasad Eye Institute , Hyderabad , India.
Purpose: To study the role of Optical coherence tomography (OCT) Angiography (OCTA) in detecting retinal vascular and macular abnormalities as compared to Fundus Fluorescein Angiography (FFA) in subjects with Asteroid hyalosis (AH).
Methods: In a prospective study, patients with AH underwent OCTA and FFA. AH graded as Grade 1 in 8 (optic disc, second order vessels visible), Grade 2 in 4 (optic disc, first-order vessels visible), Grade 3 in 11 (hazy view of optic disc) and Grade 4 (no view of fundus) in 2 eyes. Read More
Retina 2018 Nov 20. Epub 2018 Nov 20.
USC Institute for Biomedical Therapeutics, USC Roski Eye Institute, University of Southern California, Los Angeles, California.
Purpose: To analyze and provide an overview of the incidence, management, and prevention of conjunctival erosion in Argus II clinical trial subjects and postapproval patients.
Methods: This retrospective analysis followed the results of 274 patients treated with the Argus II Retinal Prosthesis System between June 2007 and November 2017, including 30 subjects from the US and European clinical trials, and 244 patients in the postapproval phase. Results were gathered for incidence of a serious adverse event, incidence of conjunctival erosion, occurrence sites, rates of erosion, and erosion timing. Read More
Am J Forensic Med Pathol 2018 Nov 20. Epub 2018 Nov 20.
Forensic Pathology and.
Biochemical analysis of cerebrospinal fluid (CSF) and vitreous humor (VH) forms an important diagnostic ancillary test at autopsy. Cerebrospinal fluid can be sampled from the ventricular system (VA) and from lumbar puncture (LP), whereas VH can be sampled from the orbits. Biochemical electrolytes seem to vary between VH and CSF collected from different sites, but whether there is any difference in glucose and β-hydroxybutyrate is unclear. Read More
Am J Forensic Med Pathol 2018 Nov 20. Epub 2018 Nov 20.
Forensic Pathology and.
Diagnosing sepsis at postmortem is challenging. With respect to meningococcal sepsis, the postmortem microbiological identification of Neisseria meningitidis is nearly always due to true infection, including in cases of decomposition. Previous case series and case reports were able to isolate N. Read More
Adv Ther 2018 Nov 24. Epub 2018 Nov 24.
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center of Sun Yat-sen University, Guangzhou, China.
Introduction: Rhegmatogenous retinal detachment (RRD) with extensive choroidal detachment (CD), suprachoroidal fluid (SCF), and lower intraocular pressure (IOP) markedly increase the difficulty of pars plana vitrectomy (PPV) because it makes the insertion and placement of the trocar cannulas for PPV time-consuming and technically challenging. In this study, we developed a systemic approach that avoids the risks of sclerotomy or using a longer trocar to help in the safe placement of the trocar cannulas in order to prevent inadvertent fluid/air perfusion during PPV in RRD eyes with extensive CD, SCF, and hypotony.
Methods: This is a prospective case series study. Read More
Eur J Ophthalmol 2018 Nov 26:1120672118815105. Epub 2018 Nov 26.
Department of Ophthalmology, School of Medicine, Marmara University, Istanbul, Turkey.
Purpose:: To identify the causative microorganism of fungal endogenous endophthalmitis in our tertiary referral uveitis center and review the therapeutic role of pars plana vitrectomy in patients with fungal endogenous endophthalmitis.
Methods:: Seven eyes of six cases were identified as fungal endogenous endophthalmitis through positive cultures of ocular fluids and clinical presentations. The final anatomical and functional results were evaluated. Read More
Ophthalmology 2018 Nov 22. Epub 2018 Nov 22.
Harvard Medical School, Department of Ophthalmology, Massachusetts Eye & Ear Infirmary, Glaucoma Service, Boston, Massachusetts.
Purpose: To assess the effect of intravitreal injections of anti-vascular endothelial growth factor (anti-VEGF) agents on immediate and long-term intraocular pressure (IOP) elevation and glaucoma.
Methods: Literature searches of the PubMed and Cochrane databases, last conducted in April 2018, yielded 253 unique citations. Of these, 41 met the inclusion criteria and were rated according to the strength of evidence. Read More
J Fr Ophtalmol 2018 Dec 22;41(10):963-967. Epub 2018 Nov 22.
Centre National Hospitalier Universitaire Hubert Koutoukou Maga, Cotonou, Bénin.
Introduction: Intravitreal injections of medication are designed to obtain a high concentration in the posterior segment. We conducted a retrospective study of our practice of intravitreal injections to assess safety of the technique and short- and medium-term tolerability, and to analyze indications and the complications.
Patients And Methods: This analytic retrospective study focused on consecutive patients treated with intravitreal injections for the period of January 2015 to June 2016 in the "Lumière" ohthalmology clinic in Cotonou, with incidents or accidents during the injection procedure as a measure of safety. Read More
Int Med Case Rep J 2018 30;11:293-296. Epub 2018 Oct 30.
Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan,
We experienced a case of sympathetic ophthalmia in a fellow eye after vitrectomy for subretinal hemorrhage related to polypoidal choroidal vasculopathy. A 60-year-old male consulted us for polypoidal choroidal vasculopathy with subretinal hemorrhage in his left eye. The recurrence of massive subretinal hemorrhage refractory to repeated pars plana vitrectomies leads to phthisis bulbi. Read More
J Ophthalmic Inflamm Infect 2018 Nov 20;8(1):21. Epub 2018 Nov 20.
Smt. Kanuri Santhamma Center for Vitreoretinal Diseases, Kallam Anji Reddy Campus, LV Prasad Eye Institute, Hyderabad, Telangana, 500034, India.
Aim: To describe the clinical presentations and management outcomes of Kocuria endophthalmitis and discuss diagnostic dilemmas DESIGN: Retrospective interventional comparative case series INTERVENTION: Eight unilateral cases with culture-proven Kocuria endophthalmitis from January 2013 to December 2017 underwent vitrectomy/vitreous biopsy and intravitreal antibiotic with or without additional procedures. The undiluted vitreous was subjected to microbiologic evaluation.
Main Outcome Measures: The mean age at presentation, etiology, number of interventions, interval between inciting event and presentation, type of intravitreal antibiotic used, and anatomic and functional outcomes were reported. Read More
Int J Retina Vitreous 2018 14;4:42. Epub 2018 Nov 14.
2Ocular Pharmacology and Pharmacy Division, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, 110029 India.
Background And Objectives: The study investigated the intravitreal safety and vitreous disposition of lisinopril, an angiotensin converting enzyme inhibitor in rabbits for its projected use in retinopathy.
Methods: For the safety study, following the baseline ERG recording and fundus photography, 40 µg/50 µl of lisinopril sterile injection was injected unilaterally in the rabbit eyes (n = 4), where other eye served as a control. The electroretinogram and fundus images were obtained at 24, 48, 72 and 168 h following the intravitreal injection. Read More
MBio 2018 Nov 20;9(6). Epub 2018 Nov 20.
Department of Pathology, University of California, San Diego, La Jolla, California, USA
Sporadic Creutzfeldt-Jakob disease (sCJD) is the most common prion disease in humans and has been iatrogenically transmitted through corneal graft transplantation. Approximately 40% of sCJD patients develop visual or oculomotor symptoms and may seek ophthalmological consultation. Here we used the highly sensitive real-time quaking-induced conversion (RT-QuIC) assay to measure postmortem prion seeding activities in cornea, lens, ocular fluid, retina, choroid, sclera, optic nerve, and extraocular muscle in the largest series of sCJD patient eyes studied by any assay to date. Read More
Ophthalmology 2018 Dec 4;125(12):1977-1983. Epub 2018 Jul 4.
Casey Eye Institute, Oregon Health & Science University, Retinal and Vitreous Diseases/Surgery, Ocular Inflammation and Immunology, Portland, Oregon.
The interleukin (IL)-23/IL-17 axis plays a central role in the pathogenesis of immune-mediated diseases such as psoriasis, psoriatic arthritis, Crohn's disease, and uveitis. Therefore, targeting the IL-23/IL-17 axis has become the focus of multiple clinical trials for drug development in patients with autoimmune diseases. We briefly describe the biology of the IL-23/IL-17 axis and its relevance to the pathogenesis of experimental and clinical uveitis, and review the monoclonal antibody therapies targeting this pathway. Read More
Ophthalmic Surg Lasers Imaging Retina 2018 Nov;49(11):e214-e217
Nd:YAG laser vitreolysis has been used as a noninvasive approach to treat visually significant vitreous strands and floaters. However, severe vision-threatening complications may occur. The authors describe a rare case of a 60-year-old woman who had suffered rupture of the posterior lens capsule with subsequent cataract formation 1 week post-Nd:YAG laser vitreolysis in the right eye. Read More
Ophthalmic Surg Lasers Imaging Retina 2018 11;49(11):904-906
Ru-ik Chee Felix Y. Chau In this case of a perforating eye injury by a 2-inch-long nail that went through the cornea, lens, and posterior eye wall, the authors describe a combined external, anterior, and posterior segment surgical approach that resulted in safe and successful removal of the foreign body. Initial external trimming of the protruding nail facilitated the use of a noncontact viewing system. Read More
Ophthalmic Surg Lasers Imaging Retina 2018 Nov;49(11):893-896
Since the publication of BEAT-ROP in 2011, intravitreal bevacizumab (IVB) has become increasingly common for the treatment of posterior type 1 retinopathy of prematurity (ROP). However, long-term data on the safety and efficacy of IVB for ROP are lacking. Vitreous hemorrhage following bevacizumab injections have been rarely reported in infants with ROP, and the need for treatment of these hemorrhages remains in question. Read More
Doc Ophthalmol 2018 Nov 19. Epub 2018 Nov 19.
Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, CEP 31270-901, Brazil.
Purpose: To assess the in vivo release profile and the retinal toxicity of a poly (lactic-co-glycolic acid) (PLGA) sustained-release sirolimus (SRL) intravitreal implant in normal rabbit eyes.
Methods: PLGA intravitreal implants containing or not SRL were prepared, and the viability of ARPE-19 and hES-RPE human retinal cell lines was examined after 24 and 72 h of exposure to implants. New Zealand rabbits were randomly divided into two groups that received intravitreal implants containing or not SRL. Read More