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    1 OF 129

    Wood's lamp for vitiligo disease stability and early recognition of initiative pigmentation after epidermal grafting.
    Int Wound J 2017 Aug 10. Epub 2017 Aug 10.
    School of Medicine, Taipei Medical University, Taipei, Taiwan.
    The prerequisite for a successful vitiligo epidermal grafting surgery is the stable status of the disease. We used Wood's lamp to assess vitiligo activity to determine the disease stability, surgical grafting timing and the early recognition of re-pigmentation after grafting. Amelanotic lesions with sharply demarcated borders are typically stable and are good candidates for grafting. Read More

    Are vitiligo treatments cost-effective? A systematic review.
    Br J Dermatol 2017 Aug 10. Epub 2017 Aug 10.
    Norfolk and Norwich University Hospital, Norfolk and Norwich University HospitalColney Lane, NR4 7UY, Norwich, United Kingdom of Great Britain and Northern Ireland.
    Vitiligo is characterised by well demarcated, cutaneous, macular depigmentation, with worldwide prevalence estimated to be between 0.2-1.8% [1]. Read More

    Mania Induced by Narrowband Ultraviolet B Phototherapy Treatment: A Case Report and Review of the Literature.
    Photodermatol Photoimmunol Photomed 2017 Aug 9. Epub 2017 Aug 9.
    Department of Dermatology, Wayne State University School of Medicine, Detroit, MI.
    Phototherapy has been used for decades in the treatment of many common dermatologic conditions, such as psoriasis, atopic dermatitis, cutaneous T cell lymphoma, vitiligo, and scleroderma, among others. Prior to the commencement of phototherapy, many factors must be considered. For dermatologists, the most important factors include the determination of a patient's skin phototype, concurrent use of photosensitizing agents, and calculation of minimal erythema dose (MED). Read More

    Global Dermatology: Learning from the Past but Still Learning from the Best?
    Open Access Maced J Med Sci 2017 Jul 18;5(4):399-402. Epub 2017 Jul 18.
    Medical Institute of Ministry of Interior (MVR), Department of Dermatology, Venereology and Dermatologic Surgery, General Skobelev 79, 1606 Sofia; Onkoderma - Policlinic for Dermatology and Dermatologic Surgery, General Skobelev 26, Sofia, Bulgaria.
    If we try to draw conclusions about events, analyse data or results (in one or a certain area) and clarify our unknown points in standard or non-standard ways, this leads to the transfer of experience from one area to another. How do we want to follow guidelines, while the most of the obligatory laws are not followed, for example? The aim of prescriptions or recommendations in medicine, for example, (or the laws of a country that do not usually apply to particular classes or castes, as well as business rules) is to give guidance on how it would be appropriate to help people or ourselves (as we have already mentioned) and the people themselves. Unfortunately, this behaviour is also characteristic of developed societies that dictate the rules and try to help … to people, as well. Read More

    Vitiligo: Mechanistic Insights Lead to Novel Treatments.
    J Allergy Clin Immunol 2017 Aug 1. Epub 2017 Aug 1.
    University of Massachuestts Medical School, Department of Dermatology, 364 Plantation St., LRB 225, Worcester, MA 01605, USA.
    Vitiligo is an autoimmune disease of the skin characterized by patchy depigmentation. Current treatments are moderately effective at reversing disease by suppressing autoimmune inflammation in the skin and promoting the regeneration of melanocytes. Recent basic and translational research studies have significantly improved our understanding of disease pathogenesis, which is now leading to emerging treatment strategies based on targeted therapy. Read More

    Autoimmune encephalitis associated with vitiligo?
    J Neuroimmunol 2017 Sep 7;310:14-16. Epub 2017 Jun 7.
    Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China. Electronic address:
    The autoimmune encephalitis can develop with or without an underlying tumor. For tumor-negative autoimmune encephalitis, the causes are still largely unknown. Here we presented three patients with autoimmune encephalitis accompanied with vitiligo. Read More

    Upregulation of Melanogenesis and Tyrosinase Activity: Potential Agents for Vitiligo.
    Molecules 2017 Aug 4;22(8). Epub 2017 Aug 4.
    Key Laboratory of Plant Resources and Chemistry of Arid Zone, Chinese Academy of Sciences, Urumqi 830011, China.
    Melanin, the compound primarily responsible in humans for hair, eye and skin pigmentation, is produced by melanocytes through a complicated process called melanogenesis that is catalyzed by tyrosinase and other tyrosinase-related proteins. The abnormal loss of melanin causes dermatological problems such as vitiligo. Hence the regulation of melanogenesis and tyrosinase activity is very important for treating hypopigmentary disorders. Read More

    Implication of REDD1 in the activation of inflammatory pathways.
    Sci Rep 2017 Aug 1;7(1):7023. Epub 2017 Aug 1.
    Université Nice Côte d'Azur, Inserm U1065, C3M, Team Cellular and Molecular Physiopathology of Obesity, Nice, France.
    In response to endotoxemia, the organism triggers an inflammatory response, and the visceral adipose tissue represents a major source of proinflammatory cytokines. The regulation of inflammation response in the adipose tissue is thus of crucial importance. We demonstrated that Regulated in development and DNA damage response-1 (REDD1) is involved in inflammation. Read More

    Spectrum Effect Relationship and Component Knock-Out in Angelica Dahurica Radix by High Performance Liquid Chromatography-Q Exactive Hybrid Quadrupole-Orbitrap Mass Spectrometer.
    Molecules 2017 Jul 21;22(7). Epub 2017 Jul 21.
    Institute of Chinese Materia Medica, Henan University, Kaifeng 475004, China.
    Different extracts of Angelica dahuricae were available for whitening or treating vitiligo clinically. They showed inhibitory or activating effects on tyrosinase, a rate-limiting enzyme of melanogenesis. This study aimed to identify active compounds on tyrosinase in water extract of Angelica dahurica Radix. Read More

    Development and in vitro assessment of psoralen and resveratrol co-loaded ultradeformable liposomes for the treatment of vitiligo.
    J Photochem Photobiol B 2017 Jul 12;174:44-57. Epub 2017 Jul 12.
    Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India. Electronic address:
    Vitiligo is a de-pigmenting skin disorder characterized by white patches on skin due to partial or complete loss of melanocytes. Psoralen in combination with ultraviolet-A (PUVA) acts by stimulation of melanin content and tyrosinase activity in melanocytes. Resveratrol, a sirtuin activator and a potential anti-oxidant reduce oxidative stress which is one of the triggering factors for initiation of vitiligo. Read More

    Localized pigmentation disorder after subcutaneous pegylated interferon beta-1a injection.
    Mult Scler 2017 Jul 1:1352458517708465. Epub 2017 Jul 1.
    Multiple Sclerosis Center, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
    We report the case of a 42-year-old female patient who developed peculiar skin lesions due to subcutaneous polyethylene glycol (PEG) interferon beta-1a. The dermatological examination showed hypochromic macules that had coalesced into a 10-cm-diameter patch. On the abdomen injection sites, there was a greyish diffuse hyperpigmentation arranged irregularly in annular macules. Read More

    Validation of an Egyptian Arabic Version of Skindex-16 and Quality of Life Measurement in Egyptian Patients with Skin Disease.
    Int J Behav Med 2017 Jul 26. Epub 2017 Jul 26.
    Department of Dermatology and Venereology, Assiut University Hospital, Assiut, 71526, Egypt.
    Purpose: To translate and cross-culturally adapt the Skindex-16, a brief skin-disease-specific QoL questionnaire, into Arabic for Egyptians and to evaluate its measurement properties in Egyptian patients with skin disease.

    Method: Translation and cultural adaption were performed following guidelines for cross-cultural adaption of health-related quality of life measures. Subsequently, Skindex-16 was administered to 500 consecutive dermatological patients and 500 healthy persons for verification of its reliability and validity. Read More

    Effect of combination of fractional CO2 laser and narrow-band ultraviolet B versus narrow-band ultraviolet B in the treatment of non-segmental vitiligo.
    Lasers Med Sci 2017 Jul 26. Epub 2017 Jul 26.
    Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt.
    The present study was designed to evaluate the effect of combining fractional CO2 laser with narrow-band ultraviolet B (NB-UVB) versus NB-UVB in the treatment of non-segmental vitiligo. The study included 20 patients with non-segmental stable vitiligo. They were divided into two groups. Read More

    Pembrolizumab-Induced Pancytopenia: A Case Report.
    Perm J 2017 ;21
    Assistant Professor of Medicine in the Department of Hematology and Oncology at the University of Arkansas for Medical Sciences in Little Rock.
    Introduction: Programmed death receptor-1 blockade with pembrolizumab is approved by the US Food and Drug Administration to treat patients with metastatic melanoma. Activating T cells to fight cancer may cause immune-mediated adverse events. Pembrolizumab-induced pancytopenia has not been previously reported in the medical literature, to our knowledge. Read More

    Resident memory T cells in the skin mediate durable immunity to melanoma.
    Sci Immunol 2017 Apr;2(10)
    Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
    Tissue-resident memory T (TRM) cells have been widely characterized in infectious disease settings; however, their role in mediating immunity to cancer remains unknown. We report that skin-resident memory T cell responses to melanoma are generated naturally as a result of autoimmune vitiligo. Melanoma antigen-specific TRM cells resided predominantly in melanocyte-depleted hair follicles and were maintained without recirculation or replenishment from the lymphoid compartment. Read More

    [Vitiligo occurring on dermal melanocytosis (nevus of Ota) in a dark-skinned patient].
    Ann Dermatol Venereol 2017 Jul 17. Epub 2017 Jul 17.
    Service de dermatologie, CHU, Treichville, Côte d'Ivoire.
    Background: Nevus of Ota is a rare disease most frequently found in Asians. It presents clinically as a bluish gray hyperpigmentation of one side of the face. Transformation into melanoma and glaucoma are the main risks. Read More

    Potential emerging treatment in vitiligo using Er:YAG in combination with 5FU and clobetasol.
    J Cosmet Dermatol 2017 Jul 19. Epub 2017 Jul 19.
    Skin Diseases and Leishmaniasis Research Center, Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
    Background: Vitiligo is a pigmentary disorder of skin affecting at least 1% of the world population of all races in both sexes. Its importance is mainly due to subsequent social and psychological problems rather than clinical complications. Various treatment choices are available for vitiligo; however, laser-based courses have shown to give more acceptable results. Read More

    Selenium, zinc, copper, Cu/Zn ratio and total antioxidant status in the serum of vitiligo patients treated by narrow-band ultraviolet-B phototherapy.
    J Dermatolog Treat 2017 Aug 1:1-6. Epub 2017 Aug 1.
    b Department of Bromatology , Medical University of Bialystok , Bialystok , Poland.
    Background: Vitiligo is a chronic, depigmenting skin disorder, whose pathogenesis is still unknown. Narrow band ultraviolet-B (NB-UVB) is now one of the most widely used treatment of vitiligo. It was suggested that trace elements may play a role in pathogenesis of vitiligo. Read More

    Fractional Er:YAG laser assisting topical betamethasone solution in combination with NB-UVB for resistant non-segmental vitiligo.
    Lasers Med Sci 2017 Jul 14. Epub 2017 Jul 14.
    Department of Dermatology, No.1 Hospital of China Medical University, 155 North Nanjing Street, Shenyang, 110001, China.
    Resistant non-segmental vitiligo is difficult to be treated. Ablative erbium-YAG (Er:YAG) laser has been used in the treatment of vitiligo, but the ablation of entire epidermis frustrated the compliance of patients. The purpose of this study is to investigate the effects of fractional Er:YAG laser followed by topical betamethasone and narrow band ultraviolet B (NB-UVB) therapy in the treatment of resistant non-segmental vitiligo. Read More

    Modified Technique of Cultured Epithelial Cells Transplantation on Facial Segmental Vitiligo.
    J Craniofac Surg 2017 Jul 13. Epub 2017 Jul 13.
    *Department of Dermatology, Huashan Hospital affiliated of Fudan University †Department of Dermatology, Jing'an District Central Hospital of Shanghai (Huashan Hospital Affiliated of Fudan University, Jing'an Branch), Shanghai, China.
    Background: Cultured epithelial cells transplantation is a known surgical technique for vitiligo.

    Objective: To evaluate the factors influencing efficacy and safety of cultured epithelial cells transplantation in 9-month follow-up.

    Methods: Demographic, clinical, and repigmentation outcomes were reviewed for patients with facial segmental vitiligo who had undergone cultured epithelial cells transplantation from November 2013 to July 2015 at the clinic of the Department of Dermatology, Huashan Hospital, China. Read More

    Supportive care for patients undergoing immunotherapy.
    Support Care Cancer 2017 Jul 13. Epub 2017 Jul 13.
    University of the Witwatersrand and Wits Donald Gordon Medical Center, Johannesburg, South Africa.
    Immune checkpoint inhibitors, a new class of cancer therapeutic agents, play an important role in the management of melanoma, NSCLC, and other malignancies. A workshop organized by three MASCC Study Groups: Oral Care, Skin Toxicities, and Neutropenia, Infection, and Myelosuppression during the MASCC Annual Meeting held in Adelaide, Australia on 23-25 June, 2016 focused on the new class of anti-cancer therapeutic agents. Topics in the workshop included the mechanism of action and clinical uses of immune anti-CTL4 and anti-PD1 antibodies, checkpoint inhibitor toxicities, including skin adverse events, gastrointestinal toxicities, oral complications, pulmonary toxicities, and endocrinological and immune-related infections. Read More

    Possible role of Helicobacter pylori in diseases of dermatological interest.
    J Biol Regul Homeost Agents 2017 APR-JUN;31(2 Suppl. 2):57-77
    Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
    Helicobacter pylori is a gram-negative, flagellate, microaerophilic bacterium identified for the first time about 30 years ago, as a pathogenic factor of gastritis and peptic ulcer. Soon after, it was linked to several gastrointestinal and extra-gastrointestinal diseases (hematological, cardiovascular, neurological, pulmonary and ocular diseases, obesity, diabetes mellitus, growth retardation and extragastric MALT lymphoma). Association and possible cause-effect correlation with H. Read More

    Hair Repigmentation During Immunotherapy Treatment With an Anti-Programmed Cell Death 1 and Anti-Programmed Cell Death Ligand 1 Agent for Lung Cancer.
    JAMA Dermatol 2017 Jul 12. Epub 2017 Jul 12.
    Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Badalona, Universitat Autònoma de Barcelona, Spain.
    Importance: New targeted therapies for cancer have been released in recent years, opening new horizons in the treatment of patients with cancer. However, their related adverse events (AE) are not fully characterized. Hair repigmentation (HR) is a nondescribed effect secondary to anti-programmed cell death 1 (anti-PD-1) and anti-programmed cell death ligand 1 (anti-PD-L1 ) therapy for treatment of lung cancer (LC), in opposition to the vitiligo reactions that develop during melanoma treatment. Read More

    A case-control study on association of proteasome subunit beta 8 (PSMB8) and transporter associated with antigen processing 1 (TAP1) polymorphisms and their transcript levels in vitiligo from Gujarat.
    PLoS One 2017 10;12(7):e0180958. Epub 2017 Jul 10.
    Department of Biochemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India.
    Background: Autoimmunity has been implicated in the destruction of melanocytes from vitiligo skin. Major histocompatibility complex (MHC) class-II linked genes proteasome subunit beta 8 (PSMB8) and transporter associated with antigen processing 1 (TAP1), involved in antigen processing and presentation have been reported to be associated with several autoimmune diseases including vitiligo.

    Objectives: To explore PSMB8 rs2071464 and TAP1 rs1135216 single nucleotide polymorphisms and to estimate the expression of PSMB8 and TAP1 in patients with vitiligo and unaffected controls from Gujarat. Read More

    Correlation between Serum Homocysteine and Vitiligo Area Scoring Index.
    Open Access Maced J Med Sci 2017 Jun 11;5(3):332-334. Epub 2017 Jun 11.
    Dermatovenereology, Faculty of Medicine, University of Sumatera Utara, Medan, North Sumatera, Indonesia.
    Background: Vitiligo is a chronic skin disorder. White macules caused by melanocyte destruction is a characteristic finding that cosmetically disturbing. Until recently, pathogenesis of vitiligo is still unclear. Read More

    Circulating CXCL10 is increased in non-segmental vitiligo, in presence or absence of autoimmune thyroiditis.
    Autoimmun Rev 2017 Sep 8;16(9):946-950. Epub 2017 Jul 8.
    Department of Clinical and Experimental Medicine, University of Pisa, Via Savi 10, 56126 Pisa, Italy. Electronic address:
    Recently the importance of CXCL10 in the pathogenesis of non-segmental vitiligo (NSV) and autoimmune thyroid disorders (AITD) has been shown. No data are present about chemokines CXCL10 (Th1 prototype) and CCL2 (Th2 prototype) circulating levels in NSV patients with/without thyroiditis (AT). Serum CXCL10 and CCL2 have been measured in 50 consecutive NSV patients, in 40 consecutive patients with NSV and AT (NSV+AT), in 50 sex- and age-matched controls without AT (control 1) and in 40 sex- and age-matched patients with AT without NSV (control 2). Read More

    Biomarkers of disease activity in vitiligo: A systematic review.
    Autoimmun Rev 2017 Sep 8;16(9):937-945. Epub 2017 Jul 8.
    Department of Dermatology, Ghent University Hospital, Ghent, Belgium.
    The pathophysiology of vitiligo is complex although recent research has discovered several markers which are linked to vitiligo and associated with disease activity. Besides providing insights into the driving mechanisms of vitiligo, these findings could reveal potential biomarkers. Activity markers can be used to monitor disease activity in clinical trials and may also be useful in daily practice. Read More

    Low-dose Methotrexate for Vitiligo.
    J Drugs Dermatol 2017 Jul;16(7):705-706

    BACKGROUND: Treatment of vitiligo is aimed at repigmentation and often consists of multiple modalities, none of which are universally or rapidly successful. Extensive cases are most often treated with ultraviolet light therapy, which can be both costly and time-consuming. Though vitiligo is an autoimmune disease, there is no current data to support systemic immunosuppressive monotherapy. Read More


    Mimicking Melanosomes: Polydopamine Nanoparticles as Artificial Microparasols.
    ACS Cent Sci 2017 Jun 18;3(6):564-569. Epub 2017 May 18.
    Materials Science and Engineering Program, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92037, United States.
    A primary role of melanin in skin is the prevention of UV-induced nuclear DNA damage to human skin cells, where it serves to screen out harmful UV radiation. Melanin is delivered to keratinocytes in the skin after being excreted as melanosomes from melanocytes. Defects in melanin production in humans can cause diseases, many of which currently lack effective treatments due to their genetic origins (e. Read More

    Cerebellar disease associated with anti-glutamic acid decarboxylase antibodies: review.
    J Neural Transm (Vienna) 2017 Jul 8. Epub 2017 Jul 8.
    National Polytechnic Institute, Mexico City, Mexico.
    Several neurological syndromes have been recognized associated to GAD antibodies. Among those disorders, cerebellar ataxia (CA) is one of the most common, along with stiff-person syndrome. Patients with GAD associated CA present with a progressive pancerebellar syndrome, with a subacute or chronic evolution, along with other neurological manifestations such as stiffness, oculomotor dysfunction, epilepsy, and cognitive dysfunction. Read More

    Vitiligo: Focus on Clinical Aspects, Immunopathogenesis, and Therapy.
    Clin Rev Allergy Immunol 2017 Jul 6. Epub 2017 Jul 6.
    INSERM U1035, ATIP-AVENIR, Université de Bordeaux, Bordeaux, France.
    Vitiligo is an acquired chronic depigmenting disorder of the skin, with an estimated prevalence of 0.5% of the general population, characterized by the development of white macules resulting from a loss of epidermal melanocytes. The nomenclature has been revised after an extensive international work within the vitiligo global issues consensus conference, and vitiligo (formerly non-segmental vitiligo) is now a consensus umbrella term for all forms of generalized vitiligo. Read More

    Autoimmune Disease in Children and Adolescents with Psoriasis: A Cross-Sectional Study in Denmark.
    Acta Derm Venereol 2017 Jul 6. Epub 2017 Jul 6.
    Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, DK-2900 Hellerup, Denmark.
    Psoriasis is an immune-mediated inflammatory disease, which, in studies among adults, have been shown to cluster with autoimmune disease. The aim of this cross-sectional register study was to examine possible associations between 9 pre-selected autoimmune diseases and psoriasis in children and adolescents. The study population consisted of all individuals living in Denmark, age under 18 years on 31 December 2012. Read More

    Cultured epidermal stem cells in regenerative medicine.
    Stem Cell Res Ther 2017 Jul 4;8(1):155. Epub 2017 Jul 4.
    Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway.
    Transplantation of cultured epidermal cell sheets (CES) has long been used to treat patients with burns, chronic wounds, and stable vitiligo. In patients with large area burns this can be a life-saving procedure. The ultimate goal, however, is to restore all normal functions of the skin and prevent scar formation. Read More

    Evaluation of Histologically and Histochemically Proven Cases of Vitiligo and its Correlation with CD4+ and CD8+ Lymphocyte Counts using Flow Cytometry.
    J Clin Diagn Res 2017 May 1;11(5):EC09-EC12. Epub 2017 May 1.
    Professor, Department of Pathology, Government Medical College, Amritsar, Punjab, India.
    Introduction: Vitiligo is an acquired cutaneous disorder characterized by progressive and selective destruction of melanocytes from the epidermis. Autoimmunity is strongly implicated in its pathogenesis. The destruction of melanocytes has a correlation with the peripheral blood lymphocyte imbalance mainly including Cytotoxic T cells (CD8+cells) and Helper T cells (CD4+cells). Read More

    Retrospective study on the characteristics and treatment of late-onset vitiligo.
    Indian J Dermatol Venereol Leprol 2017 Sep-Oct;83(5):625
    National Skin Centre; Skin Research Institue of Singapore, ASTAR, Singapore.
    Background: Late-onset vitiligo, defined as being aged 50 years and above at the point of clinical onset, remains poorly characterized till now.

    Aim: This study aims to describe the clinical characteristics and treatment response of patients with late-onset vitiligo.

    Methods: We retrospectively reviewed the case records of all patients diagnosed with late-onset vitiligo, from January 1, 2010 to December 31, 2014. Read More

    S100B: Correlation with Active Vitiligo Depigmentation.
    J Invest Dermatol 2017 Jul;137(7):1408-1410
    Department of Dermatology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. Electronic address:
    Vitiligo, the most common depigmenting disorder, is caused by immune destruction of melanocytes by cytotoxic CD8(+) T cells. One weakness in vitiligo management is the lack of an assessment method for active depigmentation. Beginning with reports about increased S100B levels in different inflammatory and tissue damage processes, Speeckaert et al. Read More

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