6,990 results match your criteria Vitiligo


Rs3213758 in the Gene Associated with Susceptibility to Segmental Vitiligo in a Chinese Han Population.

Chin Med J (Engl) 2018 Dec;131(24):3022-3024

Department of Dermatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.

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December 2018

Immune-related adverse events correlate with improved survival in patients undergoing anti-PD1 immunotherapy for metastatic melanoma.

J Cancer Res Clin Oncol 2018 Dec 11. Epub 2018 Dec 11.

Melanoma Medical Oncology Unit, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Via Venezian 1, 20133, Milan, Italy.

Background: Therapeutic chances for metastatic melanoma have consistently changed over the last years with the advent of antibodies targeting the programmed cell death protein-1 (PD-1). Onset of immune-related adverse events (irAEs) during treatment can be a source of concern, and the association with survival outcome is yet to be defined.

Patients And Methods: Data of consecutive patients treated with anti-PD1 (nivolumab or pembrolizumab) for metastatic melanoma between July 2013 and January 2018 were retrospectively reviewed. Read More

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December 2018

Regulation of melanocyte stem cells in the pigmentation of skin and its appendages: Biological patterning and therapeutic potentials.

Exp Dermatol 2018 Dec 11. Epub 2018 Dec 11.

Integrative Stem Cell Center, China Medical University Hospital, China Medical University, Taichung, 40402, Taiwan.

Skin evolves essential appendages and indispensable types of cells that synergistically insulate the body from environmental insults. Residing in the specific regions in the skin such as epidermis, dermis and hair follicle, melanocytes perform an array of vital functions including defending the ultraviolet radiation and diversifying animal appearance. As one of the adult stem cells, melanocyte stem cells in the hair follicle bulge niche can proliferate, differentiate, and keep quiescence to control and coordinate tissue homeostasis, repair, and regeneration. Read More

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December 2018
1 Read

Molecular and cellular basis of depigmentation in vitiligo patients.

Exp Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay, France.

Vitiligo is a chronic skin disease characterized by the appearance of zones of depigmentation. It is mostly described as an autoimmune disease in which the immune system destroys the melanocytes. Consistent with this origin, genetic studies have implicated genes encoding proteins mediating the immune response targeting melanocytes in the etiology of this disease, together with proteins specific to these cells. Read More

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December 2018
1 Read

Onychomatricoma in a Patient With Extensive Vitiligo.

Am J Dermatopathol 2018 Nov 22. Epub 2018 Nov 22.

Department of Dermatology, Centro Hospitalar de Lisboa Central, Lisbon, Portugal.

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November 2018

5 fluorouracil as an adjuvant therapy along with microneedling in vitiligo.

J Am Acad Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Consultant Dermatologist & Dermatosurgeon, Skinnocence: The Skin Clinic, Gurgaon, India.

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December 2018

"Vitiligo and major depressive disorder: a bidirectional population-based cohort study".

J Am Acad Dermatol 2018 Dec 5. Epub 2018 Dec 5.

Department of Community Health Sciences, Cumming School of Medicine; Department of Psychiatry, Cumming School of Medicine.

Background: Vitiligo patients often report their mental health has an impact on their skin. However, it is unknown as to whether a common mental disorder such as major depressive disorder (MDD) can also precipitate the onset of vitiligo.

Objective: Evaluate a bidirectional relationship between MDD and vitiligo using The Health Improvement Network (THIN) database. Read More

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December 2018

The influence of interferon on healthy and diseased skin.

Cytokine 2018 Dec 6. Epub 2018 Dec 6.

Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

Type I interferons (IFNs) are an immunomodulatory class of cytokines that serve to protect against viral and bacterial infection. In addition, mounting evidence suggests IFNs, particularly type I but also IFNγ, are important to the pathogenesis of autoimmune and inflammatory skin diseases, such as cutaneous lupus erythematosus (CLE). Understanding the role of IFNs is relevant to anti-viral responses in the skin, skin biology, and therapeutics for these IFN-related conditions. Read More

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December 2018
1 Read

Genus Psoralea A review of the traditional and modern uses, phytochemistry and pharmacology.

J Ethnopharmacol 2018 Dec 3. Epub 2018 Dec 3.

CSIR-National Botanical Research Institute, Plant Transgenic Laboratory, P.O. Box 436, Rana Pratap Marg,Lucknow-226 001, U.P., India. Electronic address:

Ethnopharmacological Relevance: The genus Psoralea (Fabaceae) harbours 105 accepted species that are extensively used by local peoples and medicinal practitioners of China, India, and other countries for treatment of tooth decay, psoriasis, leucoderma, leprosy, kidney problems, tuberculosis, indigestion, constipation and impotence. Presently, pharmacological research reports are available on only few species namely Bituminaria bituminosa (Syn: P. bituminosa), P. Read More

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December 2018
9 Reads

The effectiveness of topical therapy combined with 308-nm excimer laser on vitiligo compared to excimer laser monotherapy in pediatric patients.

Pediatr Dermatol 2018 Dec 5. Epub 2018 Dec 5.

Department of Dermatology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.

We evaluated the efficiency of using a 308-nm excimer laser with either tacrolimus, pimecrolimus, or halometasone for the treatment of childhood vitiligo. Patients who received combined treatments had significantly higher rates of repigmentation in comparison with individuals who underwent excimer laser alone therapy. Moreover, patients who received treatment with excimer laser and halometasone had significantly higher rates of repigmentation, even higher than individuals who were treated with tacrolimus combined or pimecrolimus combined. Read More

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December 2018
1 Read

Associated auto-immune disease in type 1 diabetes patients: a systematic review and meta-analysis.

Eur J Endocrinol 2018 Dec 1. Epub 2018 Dec 1.

O Dekkers, Internal Medicine, Leids Universitair Medisch Centrum, Leiden, Netherlands.

Introduction: The association between type 1 diabetes (T1D) and other auto-immune diseases is well-known. However, a quantitative overview of all associated auto-immune diseases and their prevalence in T1D is lacking.

Methods: We searched Pubmed, Web of Science, EMBASE and Cochrane library in September 2018 to identify relevant articles about the prevalence of the following associated auto-immune diseases in T1D cohorts: auto-immune thyroid disease, celiac disease, gastric autoimmunity including pernicious anemia, vitiligo, and adrenal gland insufficiency. Read More

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December 2018
3 Reads

Use of platelet-rich plasma to suspend noncultured epidermal cell suspension improves repigmentation after autologous transplantation in stable vitiligo: a double-blind randomized controlled trial.

Int J Dermatol 2018 Dec 2. Epub 2018 Dec 2.

Department of Dermatology & Venereology, All India Institute of Medical Sciences, New Delhi, India.

Background: Noncultured epidermal cell suspension (NCES) is an effective surgical modality for stable vitiligo which involves transplantation of the basal layer of epidermal cells onto the dermabraded vitiliginous patch. Platelet-rich plasma (PRP) has growth factors which may stimulate melanocyte migration and proliferation of keratinocytes and fibroblasts. The objective of this study was to compare the extent of repigmentation achieved by transplantation of NCES suspended in PRP with that of NCES suspended in phosphate buffered saline (PBS). Read More

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December 2018

Afamelanotide in the Treatment of Dermatologic Disease

Skin Therapy Lett 2018 11;23(6):6-10

Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA

Afamelanotide, an α-melanocyte stimulating hormone analogue, has become an emerging therapeutic option for a variety of skin conditions previously refractory to other treatments. Its efficacy has been demonstrated in several dermatologic conditions, including erythropoietic protoporphyria (EPP), solar urticaria, polymorphic light eruption (PMLE), vitiligo, acne, and Hailey-Hailey disease. Its relatively low risk side effect profile makes it an attractive treatment option and also paves the way for innovative use in other disorders. Read More

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November 2018
3 Reads

High dynamic range conversion and contrast adjustment to improve quality of dermoscopy imaging in vitiligo: A pilot study.

Indian J Dermatol Venereol Leprol 2018 Dec 5. Epub 2018 Dec 5.

Department of Dermatology, KIMS Al Shifa Hospital, Perinthalmana, Malappuram, Kerala, India.

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December 2018

Lymphoid Stress Surveillance Response Contributes to Vitiligo Pathogenesis.

Front Immunol 2018 20;9:2707. Epub 2018 Nov 20.

Department of Dermatology, University of Tartu, Tartu, Estonia.

Vitiligo is a chronic multifactorial depigmentation disorder characterized by the destruction and functional loss of melanocytes. Although a direct cytotoxic T cell attack is thought to be responsible for melanocyte damage, the events leading to the loss of self-tolerance toward melanocytic antigens are not understood. This research aimed to identify novel cellular and molecular factors that participate in vitiligo pathogenesis through the application of gene expression and immunofluorescence analysis of skin biopsy samples along with immunophenotyping of circulating cells. Read More

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November 2018
1 Read

Platelet-rich plasma versus combined fractional carbon dioxide laser with platelet-rich plasma in the treatment of vitiligo: a comparative study.

Clin Cosmet Investig Dermatol 2018 8;11:551-559. Epub 2018 Nov 8.

Dermatology Unit, Department of Medical Applications of Lasers (MAL), National Institute of Laser Enhanced Sciences, Cairo University, Giza, Egypt,

Purpose: The aim of this study was to assess the efficacy of platelet-rich plasma (PRP) vs combined fractional CO (Fr: CO) laser with PRP in the treatment of stable nonsegmental vitiligo (NSV) lesions.

Patients And Methods: This prospective, randomized, intrapatient, comparative controlled study was conducted between June 2014 and June 2016 at National Institute of Laser Enhanced Sciences (NILES), Cairo University, Cairo, Egypt. Thirty NSV patients were treated with PRP, Fr: CO laser, and combined Fr: CO laser with PRP. Read More

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November 2018
4 Reads

Patient reported outcomes for intensified versus conventional NB-UVB treatment in non-segmental vitiligo.

J Dermatolog Treat 2018 Nov 29:1-4. Epub 2018 Nov 29.

a Netherlands Institute for Pigment Disorders, Department of Dermatology , Amsterdam University Medical Centers, University of Amsterdam , Amsterdam , the Netherlands.

Introduction: Treatment of non-segmental vitiligo (NSV) remains a challenge. Efficacy of NB-UVB treatment may increase with more frequent use or in combination with topical agents. Currently, data on the most effective treatment regimen lacking. Read More

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November 2018

Is vitiligo in vogue? the changing face of vitiligo.

Cutis 2018 Oct;102(4):219-220

Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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October 2018
6 Reads

Should we prioritize psychological interventions in the management of vitiligo?

J Eur Acad Dermatol Venereol 2018 Dec;32(12):2053-2054

Association Française du Vitiligo (AFV) and Vitiligo International Patient Organizations Committee (VIPOC), Paris, France.

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December 2018

Comparison of microneedling and full surface erbium laser dermabrasion for autologous cell suspension grafting in non-segmental vitiligo: a randomized controlled trial.

Br J Dermatol 2018 Nov 29. Epub 2018 Nov 29.

Université Nice Côte d'Azur. Centre Hospitalier Universitaire Nice, Department of Dermatology. Nice, France.

Autologous cell suspension is a well-demonstrated effective approach for treating segmental or stable and localized forms of vitiligo . Full surface dermabrasion is considered as the gold standard technique for preparing the skin before grafting. Fractional ablative laser or microneedling have been shown to enhance the penetration into the skin of topical agents . Read More

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November 2018
1 Read

Evaluation of skin expression profiles of patients with vitiligo treated with narrow-band UVB therapy by targeted RNA-seq.

An Bras Dermatol 2018 Nov/Dec;93(6):843-851

Department of Biochemistry and Molecular Medicine, Facultad de Medicina, Universidad Autónoma de Nuevo León, Nuevo León, México.

Background: Vitiligo is characterized by a lack of pigmentation in the skin. To date, there are no studies that analyze the changes in gene expression in the skin of vitiligo patients in response to narrow-band ultraviolet B (nb-UVB) phototherapy treatment.

Objective: Explore the usefulness of new generation RNA sequencing in the identification of gene expression changes in the skin of vitiligo patients treated with nb-UVB phototherapy. Read More

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August 2017
2 Reads

Artificial Pigmented Human Skin Created by Muse Cells.

Adv Exp Med Biol 2018 ;1103:255-271

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

The skin composes physiological and chemical barrier and renews skin component cells throughout the human life. Melanocytes locate in the basal layer of the epidermis and produce melanin to protect the skin from ultraviolet. Melanin plays key roles in determining human skin and hair color. Read More

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January 2018

Treatment outcome and persistence of repigmentation from narrow-band ultraviolet B phototherapy in vitiligo.

J Dermatolog Treat 2018 Nov 25:1-20. Epub 2018 Nov 25.

a Department of Dermatology , Faculty of Medicine Siriraj Hospital, Mahidol University , Bangkok , Thailand.

Background: Narrow-band ultraviolet B (NB-UVB) phototherapy is a mainstay treatment in vitiligo. However, data relative to repigmentation outcome, prognostic factors, and duration of repigmentation are limited.

Objectives: To investigate the quantitative repigmentation outcome of NB-UVB phototherapy in vitiligo, the factors associated with favorable prognosis after NB-UVB, and the duration of repigmentation after NB-UVB discontinuation. Read More

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November 2018
3 Reads

Treatment with Modified Heat Shock Protein Repigments Vitiligo Lesions in Sinclair Swine.

J Invest Dermatol 2018 Dec;138(12):2505-2506

University of Massachusetts, Worcester, Massachusetts, USA. Electronic address:

HSP70i is secreted by stressed melanocytes, is associated with human vitiligo lesions, and functionally contributes to a mouse model of vitiligo. Henning et al. report that treatment with a modified version of the protein reversed depigmentation in Sinclair swine, a useful animal model of vitiligo. Read More

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December 2018
3 Reads

Autologous non-cultured melanocyte-keratinocyte transplantation in the treatment of vitiligo: patient selection and perspectives.

Clin Cosmet Investig Dermatol 2018 26;11:521-540. Epub 2018 Oct 26.

Department of Dermatology, Kasr El-Ainy Teaching Hospital, Faculty of Medicine, Cairo University, Cairo, Egypt,

Autologous non-cultured melanocyte-keratinocyte transplantation procedure (MKTP) is one of the simplest cellular grafting techniques. Various modifications were done over the years to make the technique easier and more economical which led to its great popularity among dermatologists. Proper patient selection and good technical skills are essential for achieving success with this technique. Read More

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October 2018
2 Reads

Cytokines: the yin and yang of vitiligo pathogenesis.

Expert Rev Clin Immunol 2018 Nov 21:1-12. Epub 2018 Nov 21.

a Department of Biochemistry, Faculty of Science , The Maharaja Sayajirao University of Baroda , Vadodara , India.

Introduction: Dysregulation of melanocyte function is associated with vitiligo, an idiopathic autoimmune hypopigmentary skin disorder, caused by the selective destruction of melanocytes. Cytokines, the key mediators of immune response, which are pivotal in maintaining immune homeostasis, are crucial in vitiligo pathogenesis. Several studies indicate that there is an imbalance between pro- and anti-inflammatory cytokines in the skin and serum of vitiligo patients. Read More

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November 2018

Para-tertiary butyl catechol (PTBC), an industrial antioxidant induces human platelet apoptosis.

Environ Toxicol 2018 Nov 21. Epub 2018 Nov 21.

DOS in Biochemistry, University of Mysore, Manasagangothri, Mysuru, India.

The catecholic derivative para-tertiary butyl catechol (PTBC) is a conventional antioxidant and polymerization inhibitor, which exhibits melanocytotoxic effects and contact dermatitis often leading to occupational leucoderma or vitiligo. Although numerous industrial workers will be in constant exposure to PTBC and its chances of getting entry into blood are most expected, its effect on blood components is still undisclosed. As platelets play a prominent role in dermatitis, inflammation, and immunity, in this study we have evaluated the effect of PTBC on human platelets in vitro. Read More

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November 2018
2 Reads

Design and Development of Unani Emulgel for Vitiligo.

J Ayurveda Integr Med 2018 Nov 17. Epub 2018 Nov 17.

Department of Ilmul Saidla (Unani Pharmacy), National Institute of Unani Medicine, Bangalore 560091, Karnataka, India. Electronic address:

Background: Vitiligo is not only a cosmetic problem, but also a social and psychological problem worldwide with the prevalence rate being highest in India. Treatment is unsatisfactory in Western System of Medicine. Unani System of Medicine (USM) possesses various drugs to treat vitiligo in both topical and oral dosage forms. Read More

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November 2018
7 Reads

Leukoderma induced by Rhododendrol is different from leukoderma of vitiligo in pathogenesis: a novel comparative morphological study.

J Cutan Pathol 2018 Nov 19. Epub 2018 Nov 19.

Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, Tottori University, Yonago, Japan.

Background: Rhododendrol (Rhododenol®), an inhibitor of tyrosinase activity, is used as a skin-whitening component. Many cases of leukoderma after the application have been reported, termed Rhododenol-induced leukoderma (RIL). The aim of this study was to clarify the pathogenesis of RIL morphologically through comparison with vitiligo. Read More

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November 2018
6 Reads

Blaschkoid blue vitiligo.

Int J Dermatol 2018 Nov 19. Epub 2018 Nov 19.

Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.

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November 2018
1 Read

Response of localized, resistant, tingling vitiligo to pregabalin: A case report.

Dermatol Ther 2018 Nov 19;31(6):e12702. Epub 2018 Nov 19.

CUTIS Academy of Cutaneous Sciences, Bangalore, Karnataka, India.

Vitiligo is a common depigmenting disease with complex pathogenesis. One of the proposed pathogenesis is the neural hypothesis, which suggests an altered reaction to neuropeptides, catecholamines, and their metabolites affecting melanocytes. Here, we report a case of 26-year-old female patient, whose vitiligo patches were associated with unusual crawling and tingling sensation and responded to a clinical trial of pregabalin. Read More

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November 2018

Vitiligo in a patient undergoing nivolumab treatment for non-small cell lung cancer.

JAAD Case Rep 2018 Nov 10;4(10):1042-1044. Epub 2018 Nov 10.

Department of Dermatology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.

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November 2018
2 Reads

Induction of remission in autoimmune polyglandular syndrome type three (APS III): An old drug with new perspectives.

Clin Case Rep 2018 Nov 2;6(11):2178-2184. Epub 2018 Oct 2.

Internal Medicine Department, Faculty of Medicine Alexandria University Alexandria Egypt.

The autoimmune polyglandular syndrome is a sequential chain of autoimmune events. Whenever diagnosed, the clinician's target should be induction of remission and if possible hindering its progression especially if associated with refractory vitiligo, resistant Grave's, or unexplained hyperglycemia in T1DM. Azathioprine could be used for induction of remission in autoimmune polyglandular syndrome type three especially with vitiligo and autoimmune thyroiditis. Read More

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November 2018
8 Reads

Psychodermatology: An Indian perspective.

Clin Dermatol 2018 Nov - Dec;36(6):737-742. Epub 2018 Aug 16.

Department of Dermatology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India. Electronic address:

Psychodermatology, a relatively neglected branch of dermatology in India, refers to a holistic approach to skin diseases involving not only the mind and skin, but also the cutaneous effects of psychologic stress. Among many Indian people, culture, religion, the belief in karma, and the tendency to prefer indigenous medical systems can all have a major impact on lifestyle, as well as the approach to managing various diseases, including dermatologic conditions. The origin of psychodermatology in India can be traced to Buddha's period. Read More

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August 2018
3 Reads

Intradermal injection of Fluorouracil versus triamcinolone in localized vitiligo treatment.

J Cosmet Dermatol 2018 Nov 15. Epub 2018 Nov 15.

Faculty of Medicine, Benha University, Benha, Egypt.

Background: Vitiligo is an autoimmune disease with a prevalence of 1.22% in Egypt. Intralesional steroids use in localized vitiligo treatment still a matter of debate. Read More

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November 2018
11 Reads

Aggravation of vitiligo by an electric heating pad: A possible case of heat-triggered Koebnerization in vitiligo.

J Dermatol 2018 Nov 16. Epub 2018 Nov 16.

Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.

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November 2018

JAK-inhibitors in dermatology. Current evidence and future applications.

J Dermatolog Treat 2018 Nov 15:1-22. Epub 2018 Nov 15.

a Department of Dermatology , Medical University of Warsaw , Poland , 00-008 Warsaw, Koszykowa 82a.

The Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway is a ubiquitous intracellular signaling network. Selective JAK-inhibitors have anti-inflammatory properties and have been approved in many countries for the treatment of rheumatoid arthritis (tofacitinib, baricitinib) and myelofibrosis or polycythemia vera (ruxolitinib). The aim of the publication was to summarize and critically analyze the efficacy and safety of JAK-inhibitors in skin diseases, such as psoriasis, alopecia areata, atopic dermatitis and vitiligo. Read More

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November 2018
3 Reads

Dynamic thiol/disulphide homeostasis in vitiligo patients.

Postepy Dermatol Alergol 2018 Oct 19;35(5):498-501. Epub 2018 Jul 19.

Department of Physiology, Faculty of Medicine, Harran University, Sanlıurfa, Turkey.

Introduction: Vitiligo is an acquired depigmentation disorder with melanocyte destruction.

Aim: To examine the thiol/disulphide balance in vitiligo patients and to compare the results with a healthy control group.

Material And Methods: Thirty-two patients with vitiligo and 35 healthy individuals were included in the study. Read More

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October 2018
3 Reads

Resident memory and recirculating memory T cells cooperate to maintain disease in a mouse model of vitiligo.

J Invest Dermatol 2018 Nov 10. Epub 2018 Nov 10.

University of Massachusetts Medical School, Department of Dermatology, Worcester, MA, USA. Electronic address:

Tissue resident memory T cells (Trm) form in the skin in vitiligo and persist to maintain disease, as white spots often recur rapidly after discontinuing therapy. We and others have recently described melanocyte-specific autoreactive Trm in vitiligo lesions. Here, we characterize the functional relationship between Trm and recirculating memory T cells (Tcm) in our vitiligo mouse model. Read More

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November 2018
5 Reads

Effect of puerarin on melanogenesis in human melanocytes and vitiligo mouse models and the underlying mechanism.

Phytother Res 2018 Nov 12. Epub 2018 Nov 12.

Department of Dermatology and Venereology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Puerarin is the major bioactive ingredient derived from the root of the Pueraria lobata (Willd.), and its antioxidative stress effects have been demonstrated in several previous studies. Moreover, Puerarin can upregulate melanin synthesis and microphthalmia-associated transcription factor (MITF) transcription by increasing cAMP level of intracellular cyclic adenosine monophosphate. Read More

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November 2018
2 Reads

Psoriasis in a cohort of patients with common variable immunodeficiency.

Br J Dermatol 2018 Nov 10. Epub 2018 Nov 10.

Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research, University of Naples Federico II, Naples, Italy.

Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency in adults. CVID is characterized by reduced serum levels of IgG, IgA, and/or IgM, recurrent bacterial infections, autoimmune and inflammatory diseases and malignancies. According to literature, autoimmune diseases occur in 20-30% of CVID patients. Read More

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November 2018
8 Reads

Sunburn Recall Reaction and Mucositis Secondary to Methotrexate Toxicity.

Skinmed 2018 9;16(5):340-341. Epub 2018 Nov 9.

School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA.

A 59-year-old Native American female presented with a 4-day history of malaise, abdominal pain, nausea, jaundice, and a "sunburn-like rash" on the upper chest and back despite lack of recent sun exposure (Figure 1). Medical history was significant for a twenty-year history of universal vitiligo and a five-year history of rheumatoid arthritis (RA) treated with methotrexate (MTX), adalimumab, prednisone, and naproxen sodium. Cutaneous examination revealed hemorrhagic crusting of upper and lower lips (Figure 2), scleral icterus, diffuse jaundice of the skin, and well-demarcated erythematous patches on mid-upper back and anterior neck. Read More

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November 2018
13 Reads

Vitiligo after alemtuzumab treatment: Secondary autoimmunity is not all about B cells.

Neurology 2018 Dec 7;91(24):e2233-e2237. Epub 2018 Nov 7.

From the Clinic of Neurology with Institute of Translational Neurology (T.R., S.P., A.S.-M., C.C.G., M.L., H.W., S.G.M., L.K.) and Department of Dermatology (D.M., J.E.), University of Münster; and Departments of Dermatology, Venereology, and Allergology (W.S.) and Neurology (R.P., C.K.), University School of Medicine Essen-Duisburg, Essen, Germany.

Objective: To report 3 patients with relapsing-remitting multiple sclerosis (RRMS) showing vitiligo after treatment with alemtuzumab.

Methods: Retrospective case series including flow cytometric analyses and T-cell receptor (TCR) sequencing of peripheral blood mononuclear cells.

Results: We describe 3 cases of alemtuzumab-treated patients with RRMS developing vitiligo 52, 18, and 14 months after alemtuzumab initiation. Read More

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December 2018
4 Reads

Body Piercing: A National Survey in France.

Dermatology 2019 7;235(1):71-78. Epub 2018 Nov 7.

FIMARAD, Hôpital Necker Enfants Malades, Paris, France.

Background: There are no recent data available in France regarding body piercing (BP).

Objective: We examined the demographics, motivations, quality of life, cutaneous conditions, and cutaneous side effects after BP within the French population.

Methods: A representative sample of 5,000 individuals (aged 15 and over) from the general population responded to a survey online between April and August 2017. Read More

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November 2018
2 Reads

Quenching of the Singlet and Triplet Excited States of Pterin by Amino Acids.

Photochem Photobiol 2018 Nov 7. Epub 2018 Nov 7.

Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, CCT La Plata-CONICET, La Plata, Argentina.

Unconjugated oxidized pterins accumulate in the skin of patients suffering from vitiligo and, under UVA irradiation, photosensitize the oxidation of amino acids. In this work, we study the interaction of the singlet and triplet excited states of pterin (Ptr), the parent compound of oxidized pterins, with four oxidizable amino acids: tryptophan (Trp), tyrosine (Tyr), histidine (His) and methionine (Met). Steady-state and time-resolved fluorescence measurements and laser flash photolysis experiments were performed to investigate the quenching of the Ptr excited states by the amino acids in aqueous solution. Read More

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November 2018
1 Read

What we Know About the Clinical Course of Nonsegmental Vitiligo: Experience of a Researcher and a Dermatologist.

Actas Dermosifiliogr 2018 Nov 4;109(9):767-770. Epub 2018 Jul 4.

Centro Dermatológico Dr. Ladislao de la Pascua, Ciudad de México, México.

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November 2018

Screening the Marker Components in L. with the Aids of Spectrum-Effect Relationship and Component Knock-Out by UPLC-MS².

Int J Mol Sci 2018 Nov 2;19(11). Epub 2018 Nov 2.

National Center for Research and Development of Edible Fungus Processing Technology, Henan University, Kaifeng 475004, China.

L., (), which is used for treating vitiligo in clinic, shows inhibitory and activating effects on tyrosinase, a rate-limiting enzyme of melanogenesis. This study aimed to determine the active ingredients in the ethenal extracts of on tyrosinase activity. Read More

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November 2018
1 Read
2.860 Impact Factor

Flavonoids as adjuvant in psoralen based photochemotherapy in the management of vitiligo/leucoderma.

Med Hypotheses 2018 Dec 6;121:26-30. Epub 2018 Sep 6.

Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund 643001, India.

Vitiligo is a disorder characterized by the decrease in melanin pigment of skin. This depigmenting disorder has prevalence among worldwide, irrespective of age and sex. There is an existence of different treatment modalities for the management of vitiligo. Read More

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December 2018
4 Reads

Therapeutisches Management bei Vitiligo.

J Dtsch Dermatol Ges 2018 Nov;16(11):1309-1314

Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Technische Universität München.

Vitiligo ist eine erworbene Hauterkrankung, an der weltweit 0,5 % der Bevölkerung erkranken und die eine große Herausforderung in der dermatologischen Versorgung darstellt. Die Erkrankung geht für Betroffene oftmals aufgrund der fleckigen Depigmentierung mit einer kosmetischen Entstellung und großem Leidensdruck einher. Pathophysiologisch werden als Hauptursachen für den Verlust funktionierender Melanozyten eine genetische Prädisposition, autoimmune Mechanismen und oxidativer Stress angesehen. Read More

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November 2018
2 Reads