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    Evaluation of the effect and mechanism of action of local phenytoin in treatment of vitiligo.
    J Immunoassay Immunochem 2017 Jun 22. Epub 2017 Jun 22.
    b Dermatology Department, Faculty of Medicine , Menoufia University, MSA October University , Egypt.
    There are many theories explaining vitiligo such as genetic, autoimmune, neural, free radicals, biochemical, intrinsic defect, melanocytorrhagy and convergent theories. Phenytoin is a widely used anticonvulsant, which is used in cutaneous medicine for treatment of ulcers and epidermolysis bullosa. The aim of this study is to assess the effectiveness of topical phenytoin gel in treatment of vitiligo patients and explaining the underlying mechanism using immunohistochemistry for evaluation of HMB45, CD4 and CD8. Read More

    Autoimmune diabetes induced by PD-1 inhibitor-retrospective analysis and pathogenesis: a case report and literature review.
    Cancer Immunol Immunother 2017 Jun 20. Epub 2017 Jun 20.
    AP-HP Diabetology Department, Lariboisière Hospital, Paris, France.
    Anti-PD-1 antibody treatment is approved in advanced melanoma and provides median overall survival over 24 months. The main treatment-related side effects are immune-related adverse events, which include rash, pruritus, vitiligo, thyroiditis, diarrhoea, hepatitis and pneumonitis. We report a case of autoimmune diabetes related to nivolumab treatment. Read More

    Identification of chemical components in Baidianling Capsule based on GC-MS and HPLC combined with Fourier transform ion cyclotron resonance mass spectrometry.
    J Sep Sci 2017 Jun 20. Epub 2017 Jun 20.
    School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China.
    Baidianling Capsule, which is made from 16 Chinese herbs, has been widely used for treating vitiligo clinically. In this study, the sensitive and rapid method has been developed for the analysis of chemical components in Baidianling Capsule by gas chromatography with mass spectrometry in combination with retention indices and high-performance liquid chromatography combined with Fourier transform-ion cyclotron resonance mass spectrometry. Firstly, a total of 110 potential volatile compounds obtained from different extraction procedures including alkanes, alkenes, alkyne, ketones, ethers, aldehydes, alcohols, phenols, organic acids, esters, furan, pyrrole, acid amide, heterocycle and oxide were detected from Baidianling Capsule by gas chromatography with mass spectrometry, of which 75 were identified by mass spectrometry in combination with the retention index. Read More

    8-methoxypsoralen reduces AKT phosphorylation, induces intrinsic and extrinsic apoptotic pathways, and suppresses cell growth of SK-N-AS neuroblastoma and SW620 metastatic colon cancer cells.
    J Ethnopharmacol 2017 Jun 13. Epub 2017 Jun 13.
    Department of Virology and Immunology, Maria Curie-Sklodowska University, Lublin, Poland. Electronic address:
    Ethnopharmacological Relevance: 8-methoxypsoralen (8-MOP) is a furanocoumarin and an active compound of a traditional Egyptian medicinal plant Ammi majus L, whose juice/fruit has been used for many years in folk phototherapy for the treatment of vitiligo or a hyperproliferative skin disorder, psoriasis. 8-MOP together with UVA light is also used as an anticancer drug for the treatment of cutaneous T-cell lymphoma. However, furanocoumarins exert anticancer activity even without UV irradiation. Read More

    Home Phototherapy in Vitiligo.
    Photodermatol Photoimmunol Photomed 2017 Jun 16. Epub 2017 Jun 16.
    Department of Dermatology, Henry Ford Hospital, Detroit, MI.
    Vitiligo is a disorder characterized by the development of depigmented macules and patches. Narrowband ultraviolet B phototherapy is a standard of care treatment and is used both as monotherapy and in combination with other treatment modalities to induce repigmentation. Although phototherapy is safe and effective, its use is limited due to the significant time commitment required and associated costs. Read More

    Current and emerging treatments for vitiligo.
    J Am Acad Dermatol 2017 Jul;77(1):17-29
    Department of Dermatology, University of Massachusetts Medical School, Worcester, Massachusetts.
    Clinicians should be aware that vitiligo is not merely a cosmetic disease and that there are safe and effective treatments available for vitiligo. It is important to recognize common and uncommon presentations and those with active disease, as well as their implications for clinical management; these were discussed in the first article in this continuing medical education series. Existing treatments include topical and systemic immunosuppressants, phototherapy, and surgical techniques, which together may serve to halt disease progression, stabilize depigmented lesions, and encourage repigmentation. Read More

    New discoveries in the pathogenesis and classification of vitiligo.
    J Am Acad Dermatol 2017 Jul;77(1):1-13
    Department of Dermatology, University of Massachusetts Medical School, Worcester, Massachusetts.
    Vitiligo is a common autoimmune disease that progressively destroys melanocytes in the skin, resulting in the appearance of patchy depigmentation. This disfiguring condition frequently affects the face and other visible areas of the body, which can be psychologically devastating. The onset of vitiligo often occurs in younger individuals and progresses for life, resulting in a heavy burden of disease and decreased quality of life. Read More

    [Progress of research on TXNDC5].
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2017 Jun;34(3):448-450
    Medical Research Center of Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, China.
    The protein encoded by TXNDC5 is a member the protein disulfide isomerase family, which has disulfide isomerase activity and can act as the molecular chaperone to reduce the synthesis of abnormal proteins. Its biological functions include anti-oxidation, promoting angiogenesis, taking part in cellular inflammation, and energy metabolism, etc. Studies have demonstrated that the expression of TXNDC5 is increased in many types of tumors including cervical carcinoma, gastric carcinoma and colorectal cancer. Read More

    Immune-related adverse events by immune checkpoint inhibitors.
    Nihon Rinsho Meneki Gakkai Kaishi 2017 ;40(2):83-89
    Department of Dermatology, St. Marianna University School of Medicine.
      Recent introduction of immune checkpoint inhibitors represented by anti-PD-1 antibodies such as nivolumab and pembrolizumab, and anti-CTLA-4 antibody such as ipilimumab had a great impact on cancer immunotherapy especially for melanoma, non-small cell lung cancer, renal cell carcinoma, and Hodgkin's lymphoma. On the other hand, immune checkpoint inhibitors have their own distinctive adverse events, which are collectively named as "immune-related adverse events". Although immune-related adverse events may occur at any part of the body, interstitial pneumonia, colitis, hypothyroidism, liver dysfunction, skin rash, vitiligo, hypophysitis, type 1 diabetes, renal dysfunction, myasthenia gravis, neuropathy, myositis, and uveitis are representative. Read More

    Usefulness of ischemia-modified albumin in predicting oxidative stress in patients with vitiligo.
    Biomark Med 2017 Jun 9. Epub 2017 Jun 9.
    Gazi University, Faculty of Medicine, Biochemistry, Ankara, Turkey.
    Aim: To investigate the emphasis of oxidative stress in the pathogenesis of vitiligo through an evaluation of ischemia-modified albumin (IMA). Results/methodology: IMA was of higher statistical significance in patients than in the control group (IMA: 0.57 ± 0. Read More

    A comparative study for the short-term effects of targeted high-intensity UVB and narrow-band UVB in the treatment of vitiligo.
    Exp Ther Med 2017 Jun 26;13(6):3383-3387. Epub 2017 Apr 26.
    Department of Dermatology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China.
    Vitiligo is a common acquired depigmentation disorder for which many treatments have previously been used with varying effects. The aim of the present study was to evaluate the efficacy and safety of targeted high-intensity (TH) and narrow band (NB) ultraviolet B light (UVB) for vitiligo treatment. A total of 33 patients with vitiligo were enrolled in the present study. Read More

    Use of Topical Corticosteroids in Dermatology: An Evidence-based Approach.
    Indian J Dermatol 2017 May-Jun;62(3):237-250
    Department of Dermatology, KPC Medical College and Hospital, Kolkata, West Bengal, India.
    Topical corticosteroids (TCs) are the pillars of dermatotherapeutics. These drugs are the "magic molecules," provided they are used judiciously and appropriately, following a rational prescription. On exhaustive literature search in multiple databases, we found a significant evidence favoring the use of TCs in atopic eczema, localized vitiligo, psoriasis, chronic hand eczema, and localized bullous pemphigoid. Read More

    Importance of Light in the Treatment of Vitiligo with JAK-inhibitors.
    J Dermatolog Treat 2017 Jun 5:1-8. Epub 2017 Jun 5.
    a Department of Dermatology , Tufts Medical Center , Boston MA.
    Vitiligo is an autoimmune pigmentary disorder characterized by depigmented patches of skin with a selective loss of melanocytes. Recent advances describe vitiligo as a T-helper (Th1) cell-mediated disease with elevated levels of IFN-γ and its associated chemokines CXCL9 and CXCL10 responsible for depigmentation. The Janus kinase (JAK) inhibitors have shown promise for the treatment of vitiligo with improved response in the sun-exposed areas. Read More

    [Vogt-Koyanagi-Harada disease].
    J Fr Ophtalmol 2017 Jun 1;40(6):512-519. Epub 2017 Jun 1.
    Université Paris Descartes, 75014 Paris, France; Centre Cochin ambulatoire d'ophtalmologie, groupe hospitalier Cochin-Hôtel-Dieu, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France.
    Vogt-Koyanagi-Harada (VKH) disease is defined as a severe bilateral, chronic granulomatous panuveitis associated with serous retinal detachments, disk edema, and vitritis, with central nervous system, auditory, and integumentary manifestations. It is an autoimmune inflammatory condition mediated by T cells that target melanocytes in individuals genetically susceptible to the disease. Vogt-Koyanagi-Harada disease presents clinically in 4 different phases: prodromal, acute inflammatory, chronic, and recurrent, with extraocular manifestations including headache, meningitis, hearing loss, poliosis, and vitiligo. Read More

    Vitiligo in a patient with lung adenocarcinoma treated with nivolumab: A case report.
    Lung Cancer 2017 Jul 27;109:42-44. Epub 2017 Apr 27.
    Department of Thoracic Oncology, Toneyama National Hospital, Osaka, Japan. Electronic address:
    Nivolumab, an anti-programmed cell death-1 protein monoclonal antibody, is effective for treating patients with late-stage non-small-cell lung cancer. Immune checkpoint inhibitors such as nivolumab induce various kinds of immune-related adverse events, including vitiligo. Vitiligo has been reported in patients with melanoma but not lung cancer. Read More

    Vitiligo: An Update on Pathophysiology and Treatment Options.
    Am J Clin Dermatol 2017 Jun 2. Epub 2017 Jun 2.
    Department of Dermatology, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium.
    The pathophysiology of vitiligo is becoming increasingly clarified. In non-segmental vitiligo, early factors include activation of innate immunity, inflammasome activation, oxidative stress, and loss of melanocyte adhesion. Nonetheless, the main mechanism leading to non-segmental vitiligo involves an immune-mediated destruction of melanocytes. Read More

    A holistic review on the autoimmune disease vitiligo with emphasis on the causal factors.
    Biomed Pharmacother 2017 May 30;92:501-508. Epub 2017 May 30.
    Department of Marine Chemistry and Natural Products, Ocean College, Zhejiang University, Hangzhou, 310058, PR China.
    Vitiligo is an idiopathic systemic autoimmune disease affecting skin, hair and oral mucosa. This genetic yet acquired disease characterized by melanin loss is a cause of morbidity across all races. Though thyroid disturbance has been recognized as a key trigger of this pathology, an array of other factors plays critical role in its manifestation. Read More

    Multivariate Analysis of Factors Associated with the Koebner Phenomenon in Vitiligo: An Observational Study of 381 Patients.
    Ann Dermatol 2017 Jun 11;29(3):302-306. Epub 2017 May 11.
    Vitiligo Research Chair, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
    Background: The Koebner phenomenon (KP) is a common entity observed in dermatological disorders. The reported incidence of KP in vitiligo varies widely. Although the KP is frequently observed in patients with viltiligo, the associated factors with KP has not been established yet. Read More

    Effect of intensive glucose control on microvascular events in people with type 2 diabetes.
    • Authors:
    Drug Ther Bull 2017 Jun 31;55(6):62. Epub 2017 May 31.
    Effect of intensive glucose control on microvascular events in people with type 2 diabetes ● Febrile seizures in children: benefits and risks of prophylactic drug management More on gastric acid suppression and C difficile risk ● What next for the cardiovascular polypill? ● EMA recommends suspension of some generic drugs ● Phototherapy for vitiligo ● WHO targets medication-related errors. Read More

    Alopecia Areata of the Beard: A Review of the Literature.
    Am J Clin Dermatol 2017 May 29. Epub 2017 May 29.
    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1475 NW 12th Ave., Miami, FL, 33136, USA.
    Alopecia areata (AA) is a T-cell mediated autoimmune disorder in which inflammatory cells attack the hair follicle, resulting in round, well-circumscribed patches of noncicatricial hair loss in normal appearing skin. AA affecting the beard area is well known and is referred to as AA of the beard (BAA) or AA barbae when involvement is limited exclusively to the beard. BAA has been documented in a select number of studies. Read More

    8-Methoxypsoralen disrupts MDR3-mediated phospholipids efflux and bile acid homeostasis and its relevance to hepatotoxicity.
    Toxicology 2017 May 24;386:40-48. Epub 2017 May 24.
    Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China; Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing 210009, China. Electronic address:
    Since its discovery in 1987, multidrug resistance 3 P-glycoprotein (MDR3) had recognized to play a crucial role in the translocation of phospholipids from the inner to outer leaflets of bile canalicular membranes. An increasing number of reports suggest that drug-mediated functional disruption of MDR3 is responsible for drug-induced cholestasis. 8-Methoxypsoralen (8-MOP) is used clinically to treat psoriasis, vitiligo and other skin disorders. Read More

    Oxidation products are increased in patients affected by non-segmental generalized vitiligo.
    Arch Dermatol Res 2017 May 27. Epub 2017 May 27.
    School and Division of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
    Several lines of evidence support the relevance of reactive oxygen species (ROS) in vitiligo, but the exact role of glycation and oxidation of macromolecules needs to be better addressed. To investigate the involvement of advanced oxidation protein products (AOPPs) and advanced glycation end-products (AGEs), we performed a case-control association study by spectrofluorimetry and spectrophotometry, in 47 patients with non-segmental generalized vitiligo and 47 age- and sex-matched controls. Significantly higher levels of both AOPPs (p < 0. Read More

    An in-depth analysis identifies two new independent signals in 11q23.3 associated with vitiligo in the Chinese Han population.
    J Dermatol Sci 2017 May 3. Epub 2017 May 3.
    Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, China; Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China. Electronic address:
    Background: Vitiligo is an autoimmune disease, characterized by progressive loss of skin pigmentation, which is caused by the interactions of multiple factors, such as heredity, immunity and environment. Recently, a single nucleotide polymorphism (SNP) rs638893 at 11q23.3 region was identified as a risk factor for vitiligo in genome-wide association studies and multiple SNPs in this region have been associated with other autoimmune diseases. Read More

    The first transepidermal transplantation of non-cultured epidermal suspension using a dermarolling system in vitiligo: A sequential histological and clinical study.
    Pigment Cell Melanoma Res 2017 May 19. Epub 2017 May 19.
    Vitiligo Melasma Research Association, 2, Corniche de la Meyjande, Lacanau, 33680, France.
    The current methods for melanocyte delivery to depigmented skin are invasive and often require sophisticated approaches. Here we describe a promising simple and minimally invasive technique based on the dermarolling system. The technique involves preparation of a keratinocyte/melanocyte suspension prepared by trypsinization from a non-lesioned part of a patient's scalp skin and transepidermal delivery using a dermaroller equipped with 0. Read More

    Immune and molecular correlates in melanoma treated with immune checkpoint blockade.
    Cancer 2017 Jun;123(S11):2143-2153
    Department of Dermatology and Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
    Immunotherapy for metastatic melanoma has a decades-long history, and the relatively recent use of checkpoint inhibitors has revolutionized treatment. Durable and sometimes complete remission of metastatic melanoma is now achievable in some patients who receive checkpoint-blocking therapy. However, it is unclear why some patients fare better than others. Read More

    Catalase (CAT) promoter and 5'-UTR genetic variants lead to its altered expression and activity in vitiligo.
    Br J Dermatol 2017 May 25. Epub 2017 May 25.
    Department of Biochemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India, 390002.
    Background: Oxidative stress is considered to be the initial event during the course of vitiligo. Catalase is mainly involved in the defense against oxidizing agents in the cell through detoxifying H2 O2 .

    Objectives: Aims of the present study were 1) to assess the erythrocyte catalase activity and LPO levels, as well as CAT mRNA expression in skin and blood; 2) to investigate CAT promoter rs7943316, rs1001179; 5'-UTR rs1049982 and exon (rs17886350, rs11032709, rs17880442, rs35677492) polymorphisms and; 3) to perform genotype-phenotype/ haplotype correlation analyses, in vitiligo patients and controls from Gujarat. Read More

    Efficacy of Cyclosporine After Autologous Noncultured Melanocyte Transplantation in Localized Stable Vitiligo-A Pilot, Open Label, Comparative Study.
    Dermatol Surg 2017 May 22. Epub 2017 May 22.
    *Department of Dermatology, Maharashtra Medical Foundation-Joshi Hospital, Pune, India;†Department of Dermatology, Shah Skin and Laser Center, Solapur, India.
    Background: Understanding the pathogenesis of vitiligo has lead to innovation of new drugs and new uses of the existing drugs to enhance treatment outcome.

    Objective: The aim of this observational pilot study was to assess the role of cyclosporine (CsA) to tackle the commonest aesthetic problem "perilesional halo" after autologous noncultured melanocyte-keratinocyte cell transplant (NCMKT) for localized, stable vitiligo.

    Materials And Methods: Of the total 50 enrolled patients who underwent NCMKT for stable/resistant vitiligo, aged 12 to 68 years (mean 29. Read More

    Autologous Biological Dressing for Recipient Area in Cellular Grafting of Vitiligo.
    Dermatol Surg 2017 May 22. Epub 2017 May 22.
    Department of Dermatology and Venereology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana, Ambala, IndiaDepartment of Dermatology, KIMS Alshifa Super Speciality Hospital, Perinthalmanna, Kerala, IndiaAll India Institute of Medical Sciences, New Delhi, India.

    Protective effect of madecassoside on H2O2-induced oxidative stress and autophagy activation in human melanocytes.
    Oncotarget 2017 May 7. Epub 2017 May 7.
    Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, 210029, P.R. China.
    Background: Centella asiatica (L.) Urb. is a traditional Chinese medicine that has many medical applications, including wound healing and anti-oxidation. Read More

    Vitamin D status and the effects of oral vitamin D treatment in children with vitiligo: A prospective study.
    Clin Nutr ESPEN 2016 Oct 9;15:28-31. Epub 2016 Jun 9.
    Department of Pediatric Endocrinology, Karadeniz Technical University, School of Medicine, Trabzon 61080, Turkey.
    Background & Aims: Vitiligo is a pigmentary disorder and autoimmune pathogenesis seems most likely. Decreased vitamin D levels have been related to several autoimmune diseases. Little is known about the association of vitiligo and vitamin D. Read More

    Case Report: Behçet's disease accompanied with vitiligo.
    F1000Res 2017 23;6:310. Epub 2017 Mar 23.
    Dermatology Department, Kayseri Training and Research Hospital, Kayseri, 38050, Turkey.
    Recently, a few case reports and clinical studies have been published that explore the association of Behçet's Disease (BD) and vitiligo, with conflicting results. Genetic and immunological properties of BD and presence of autoantibodies support autoimmunity, but clinical features suggest autoinflammatory diseases. BD is thought to be a cornerstone between autoimmune and autoinflammatory diseases. Read More

    Evolution, immunity and the emergence of brain superautoantigens.
    F1000Res 2017 21;6:171. Epub 2017 Feb 21.
    Bank of Tissues and Cells, Lyon University Hospital (Hospices Civils de Lyon), CarMeN Laboratory, INSERM 1060, INRA 1397, INSA Lyon, Université Claude Bernard Lyon-1, Lyon, F-69000, France.
    While some autoimmune disorders remain extremely rare, others largely predominate the epidemiology of human autoimmunity. Notably, these include psoriasis, diabetes, vitiligo, thyroiditis, rheumatoid arthritis and multiple sclerosis. Thus, despite the quasi-infinite number of "self" antigens that could theoretically trigger autoimmune responses, only a limited set of antigens, referred here as superautoantigens, induce pathogenic adaptive responses. Read More

    Vitiligo: Not Simply a Skin Disease.
    Skinmed 2017 1;15(2):125-127. Epub 2017 Apr 1.
    Department of Dermatology, Robert Wood Johnson Medical School, Rutgers University, Somerset, NJ.
    Melanocytes, the cells responsible for skin pigmentation, are present in other parts of the body, such as the ocular, auditory, nervous, and cardiac systems. Within these systems, their roles serve a different purpose than their classical counterparts in skin as pigment cells. Such roles include cell turnover in retinal pigment epithelium, maintenance of balance and prevention of environmental damage in the auditory neuroepithelium, role-playing as dendritic cells within the leptomeninges, and prevention of oxidative damage in adipose tissue. Read More

    MicroRNA in skin diseases.
    Eur J Dermatol 2017 May 19. Epub 2017 May 19.
    Department of Pathophysiology, Krasnoyarsk State Medical University, P. Zeleznyaka str. 1, 660022, Krasnoyarsk, Russian Federation.
    MicroRNAs are essential regulators of various cellular processes such as cell growth, differentiation, apoptosis, and the immune response, acting as factors for translational repression and/or degradation of target messenger RNA. Currently, microRNAs are considered as promising biomarkers and therapeutic targets for different pathological conditions. Skin may serve as a convenient model for microRNA modulation studies due to the comparatively easy access to targets cells. Read More

    Cutaneous adverse effects during ipilimumab treatment for metastatic melanoma: a prospective study.
    Eur J Dermatol 2017 May 19. Epub 2017 May 19.
    Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
    Ipilimumab is an immunomodulatory antibody directed against cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), which is administered to patients with advanced melanoma, with a proven positive effect on overall survival. The cutaneous adverse effects (AEs) of ipilimumab are relatively frequent, although described as usually mild and rarely life threatening. To describe a three-year experience of a single institute in detecting and managing cutaneous AEs. Read More

    A Comparison of Betamethasone Valerate 0.1% Cream Twice Daily Plus Oral Simvastatin Versus Betamethasone Valerate 0.1% Cream Alone in the Treatment of Vitiligo Patients.
    Adv Biomed Res 2017 28;6:34. Epub 2017 Mar 28.
    Skin Diseases and Leishmaniasis Research Center, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran.
    Background: Vitiligo, a common disorder of depigmentation, is often difficult to treat. Corticosteroids are known to be effective, but with modest results. Although simvastatin has been reported to be effective for immunorelated dermatologic disorders including vitiligo, controlled trials are lacking. Read More

    Topical mycophenolate mofetil in the treatment of vitiligo: a pilot study.
    Dermatol Pract Concept 2017 Apr 30;7(2):31-33. Epub 2017 Apr 30.
    Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
    Background: Vitiligo is a multifactorial disease that is characterized by circumscribed depigmented macules and patches. Autoimmune reactions may play an important role in the pathogenesis of the disease. Mycophenolate mofetil is a drug that inhibits DNA synthesis in lymphocytes and has been used in autoimmune diseases such as immunobullous skin diseases, lupus erythematosus, and autoimmune hepatitis. Read More

    Psychosomatic aspects of vitiligo.
    Clin Dermatol 2017 May - Jun;35(3):292-297. Epub 2017 Jan 21.
    Sector of Dermatology and Post-Graduation Course, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
    Vitiligo is a chronic common skin disease. The asymptomatic hypopigmented cutaneous lesions are considered by many health care professionals as a cosmetic problem only; however, vitiligo can have a major psychosocial impact on patients' lives. We review some of the factors responsible for this impact, such as the general public's wrong perception of the disease, feelings and emotional responses from patients, how stressful events can act as triggers of the disease, stigmatization experiences suffered by the patients, the prevalence of psychiatric morbidity, the effects on relationships and sex life, how quality of life in adults and children is impaired, and how treatment can improve it. Read More

    Skin diseases and tattoos: a five-year experience.
    G Ital Dermatol Venereol 2017 May 16. Epub 2017 May 16.
    Department of Dermatology, University of Naples Federico II, Naples, Italy -
    Background: Decorative tattooing as a body art form underwent an exponential increase during the last two decades, particularly among teenagers and young adults. Consequently, the number of reported adverse reactions after tattooing has increased. The most frequent reported skin reactions to tattoo include infectious (bacterial, viral, fungal) or inflammatory (allergic contact dermatitis and granulomatous reaction) diseases. Read More

    Antimicrobial, anticancer, and antioxidant compounds from Premna resinosa growing in Saudi Arabia.
    Pharm Biol 2017 Dec;55(1):1759-1766
    b Department of Pharmacognosy, College of Pharmacy , King Saud University , Riyadh , Saudi Arabia.
    Context: Premna resinosa (Hochst.) Schauer (Lamiaceae) is used in many places to treat bronchitis, respiratory illness and convulsions of the rib cage.

    Objective: This study evaluates the anticancer, antimicrobial and antioxidant activities of P. Read More

    Evaluation of the serum zinc level in patients with vitiligo.
    Postepy Dermatol Alergol 2017 Apr 13;34(2):116-119. Epub 2017 Apr 13.
    Department of Dermatology, Imam Khomeini Hospital, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
    Introduction: Vitiligo is an acquired, idiopathic disorder characterized by circumscribed depigmented macules and patches, which affects approximately 0.1-2% of the general population worldwide. Zinc is an essential trace element that is necessary for growth and development at all stages of life. Read More

    MicroRNA-211 regulates oxidative phosphorylation and energy metabolism in human vitiligo.
    J Invest Dermatol 2017 May 11. Epub 2017 May 11.
    Sanford Burnham Prebys Medical Discovery Institute, 6400 Sanger Road, Orlando, FL. Electronic address:
    Vitiligo is a common, chronic skin disorder characterized by loss of epidermal melanocytes and progressive depigmentation. Vitiligo has complex immune, genetic, environmental, and biochemical etiology, but the exact molecular mechanisms of vitiligo development and progression, particularly those related to metabolic control, are poorly understood. Here we characterized the human vitiligo cell line PIG3V and the normal human melanocytes, HEM-l by RNA-sequencing (RNA-seq), targeted metabolomics, and shotgun lipidomics. Read More

    Long-term follow-up of patients undergoing autologous noncultured melanocyte-keratinocyte transplantation for vitiligo and other leukodermas.
    J Am Acad Dermatol 2017 May 11. Epub 2017 May 11.
    Department of Dermatology, Multicultural Dermatology Center, Henry Ford Hospital, Detroit, Michigan. Electronic address:
    Background: Persistence of pigmentation after a melanocyte-keratinocyte transplantation procedure (MKTP) is an important consideration for efficacy.

    Objective: We sought to determine long-term repigmentation of MKTP in vitiligo and other leukodermas.

    Methods: A retrospective review of electronic medical records was conducted for all MKTPs performed at Henry Ford Hospital between January 2009 and April 2014. Read More

    Altered expression of four miRNA (miR-1238-3p, miR-202-3p, miR-630 and miR-766-3p) and their potential targets in peripheral blood from vitiligo patients.
    J Dermatol 2017 May 13. Epub 2017 May 13.
    Department of Dermatology, The First Affiliated Hospital, and College of Clinical Medicine of Zhengzhou University, Zhengzhou, China.
    Vitiligo is an acquired skin disease with pigmentary disorder. Autoimmune destruction of melanocytes is thought to be major factor in the etiology of vitiligo. miRNA-based regulators of gene expression have been reported to play crucial roles in autoimmune disease. Read More

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