7,076 results match your criteria Vitiligo


Six-year follow-up of vitiligo patients successfully treated with autologous non-cultured melanocyte-keratinocyte transplantation.

J Eur Acad Dermatol Venereol 2019 Feb 22. Epub 2019 Feb 22.

Department of Dermatology, APHP, Hôpital Henri Mondor, Université Paris-Est, Créteil, France.

Background: Although autologous non-cultured melanocyte-keratinocyte transplantation is a treatment option for stable vitiligo, there is lack of long-term maintenance data for this specific treatment.

Objective: To search for factors associated with long-term maintenance of patients with stable vitiligo successfully treated with melanocyte-keratinocyte transplantation.

Methods: This was a single-centre retrospective study including stable vitiligo patients who underwent successful melanocyte-keratinocyte transplantation in the National Center for Vitiligo, Riyadh, Saudi Arabia, between 1 January 2004 and 30 June 2015. Read More

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http://dx.doi.org/10.1111/jdv.15411DOI Listing
February 2019

Markedly Reduced Risk of Internal Malignancies in Patients With Vitiligo: A Nationwide Population-Based Cohort Study.

J Clin Oncol 2019 Feb 20:JCO1801223. Epub 2019 Feb 20.

11 Yeouido St Mary's Hospital College of Medicine, The Catholic University of Korea, Seoul, Korea.

Purpose: Recent studies indicated that the autoimmunity of vitiligo exerts effects on cells other than melanocytes, which confer reduced risks of both melanoma and nonmelanoma skin cancers in patients with vitiligo. However, the risk of internal malignancy in patients with vitiligo has not been elucidated.

Patients And Methods: We conducted a population-based retrospective cohort study using data from the Korean National Health Insurance claims database obtained from January 2007 to December 2016. Read More

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http://dx.doi.org/10.1200/JCO.18.01223DOI Listing
February 2019

Melanocyte spheroids are formed by repetitive long-term trypsinization.

Indian J Dermatol Venereol Leprol 2019 Feb 20. Epub 2019 Feb 20.

Department of Dermatology, The First Affiliated Hospital of Bengbu Medical College, Anhui, China.

Background: Autologous melanocyte transplantation plays an important role in the treatment of vitiligo.

Objective: Previous studies have indicated that, compared with melanocytes growing in monolayers, melanocyte spheroids have a better survival in growth factor- and serum-deprived conditions.

Methods: Melanocyte spheroids were obtained from human epidermis by repetitive long-term trypsinization and maintained an aggregated morphology for a short period in certain conditions. Read More

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http://www.ijdvl.com/preprintarticle.asp?id=252577;type=0
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http://dx.doi.org/10.4103/ijdvl.IJDVL_275_17DOI Listing
February 2019
1 Read

Quality of Life is Markedly Impaired by Rheumatological and Skin Manifestations in Patients with Type 1 Diabetes: A Questionnaire Survey.

Diabetes Ther 2019 Feb 19. Epub 2019 Feb 19.

Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.

Introduction: To estimate lifetime prevalence of diabetes-related upper limb and non-acquired skin manifestations in a representative type 1 diabetes (T1D) population and to identify associations between these conditions and quality of life.

Methods: A questionnaire on these complications and measures of quality of life (World Health Organization-Five Well-Being Index [WHO-5]), depression, and diabetes-specific burden (Problem Areas in Diabetes [PAID] scale) was sent to all T1D patients in a Danish clinic (N = 583).

Results: The response rate was 68. Read More

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http://dx.doi.org/10.1007/s13300-019-0587-5DOI Listing
February 2019

Nuclear genetic regulation of the human mitochondrial transcriptome.

Elife 2019 Feb 18;8. Epub 2019 Feb 18.

Department of Medical and Molecular Genetics, King's College London, London, United Kingdom.

Mitochondria play important roles in cellular processes and disease, yet little is known about how the transcriptional regime of the mitochondrial genome varies across individuals and tissues. By analyzing >11,000 RNA-sequencing libraries across 36 tissue/cell types, we find considerable variation in mitochondrial-encoded gene expression along the mitochondrial transcriptome, across tissues and between individuals, highlighting the importance of cell-type specific and post-transcriptional processes in shaping mitochondrial-encoded RNA levels. Using whole-genome genetic data we identify 64 nuclear loci associated with expression levels of 14 genes encoded in the mitochondrial genome, including missense variants within genes involved in mitochondrial function (, and ), implicating genetic mechanisms that act in across the two genomes. Read More

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http://dx.doi.org/10.7554/eLife.41927DOI Listing
February 2019

Clinico-Epidemiological Profile of Patients with Vitiligo: A Retrospective Study from a Tertiary Care Center of North India.

Indian Dermatol Online J 2019 Jan-Feb;10(1):38-44

Department of Dermatology, Venereology and Leprosy, Dr. R. P. Govt. Medical College, Kangra (Tanda), Himachal Pradesh, India.

Background: We studied clinico-epidemiological features of 945 patients with vitiligo with an objective to delineate epidemiological and clinical aspects of vitiligo from this part of the country.

Materials And Methods: The medical records of patients with vitiligo attending outpatient clinic over a 5-year period from January 2013 to December 2017 were analyzed retrospectively for this descriptive, observational study.

Results: There were 449 men and 496 women (m:f 1:1. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_124_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362747PMC
February 2019

Radiation-induced morphea: autoimmunity as a risk factor.

Neth J Med 2019 Jan;77(1):29-31

Department of Dermatology, Mohammed V Military Hospital, Mohammed V University of Rabat, Rabat, Morocco.

Radiation-induced morphea (RIM) is a rare complication of radiotherapy of unknown etiology. We report the case of a woman with a history of vitiligo and Hashimoto's thyroiditis, who developed RIM following radiotherapy for breast carcinoma. We suggest that a history of autoimmune disease is a possible risk factor for the development of RIM. Read More

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January 2019

Emerging role of immune cell network in autoimmune skin disorders: An update on pemphigus, vitiligo and psoriasis.

Cytokine Growth Factor Rev 2019 Feb 8. Epub 2019 Feb 8.

Department of Biochemistry, All India Institute of Medical Sciences, AIIMS, New Delhi, India. Electronic address:

Autoimmune skin diseases are a group of disorders that arise due to a deregulated immune system resulting in skin tissue destruction. In the majority of these conditions, either autoreactive immune cells or the autoantibodies are generated against self-antigens of the skin. Although the etiology of these diseases remains elusive, biochemical, genetic, and environmental factors such as infectious agents, toxins damage the skin tissue leading to self-antigen generation, autoantibody attack and finally results in autoimmunity of skin. Read More

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http://dx.doi.org/10.1016/j.cytogfr.2019.01.001DOI Listing
February 2019

Juvenile polyautoimmunity in a rheumatology setting.

Autoimmun Rev 2019 Feb 14. Epub 2019 Feb 14.

Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia.. Electronic address:

Overt polyautoimmunity (PolyA) corresponds to the presence of more than one well-defined autoimmune disease (AD) manifested clinically in a single patient. The current study aimed to describe the main characteristics of juvenile PolyA in a pediatric rheumatology setting and analyze the chronological aspects, index cases, familial autoimmunity, and clustering pattern. This was a cross-sectional and multicenter study in which 313 children with overt PolyA were included. Read More

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http://dx.doi.org/10.1016/j.autrev.2018.11.006DOI Listing
February 2019
1 Read

Ratiometric target-triggered fluorescent silicon nanoparticles probe for quantitative visualization of tyrosinase activity.

Talanta 2019 May 5;197:113-121. Epub 2019 Jan 5.

CAS Key Laboratory of Chemistry of Northwestern Plant Resources, Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, PR China. Electronic address:

Tyrosinase is the key enzyme in the treatment of vitiligo. Development of rapid, simple, and visual methods for screening bioactive compounds with tyrosinase activity from natural compounds is interesting for new drug discovery. Herein, a novel visual ratiometric fluorescent assay for screening tyrosinase activators and/or inhibitors based on silicon nanoparticles (Si NPs) was explored. Read More

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http://dx.doi.org/10.1016/j.talanta.2019.01.002DOI Listing
May 2019
1 Read

A Summary of 2018 and What Lies Ahead for Dermatology and Therapy in 2019.

Dermatol Ther (Heidelb) 2019 Mar 15;9(1):1-3. Epub 2019 Feb 15.

Dermatology Centre, Salford Royal NHS Foundation Trust, Manchester NIHR BRC, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1007/s13555-019-0283-4DOI Listing
March 2019
1 Read

Comparison of efficacy of cold trypsinization versus warm trypsinization in preparation of autologous noncultured epidermal cell suspension for treatment of stable vitiligo.

J Eur Acad Dermatol Venereol 2019 Feb 15. Epub 2019 Feb 15.

Department of Dermatology, Venereology, and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh-160012, India.

Surgical modalities are the mainstay of treatment for medically resistant vitiligo. Among various techniques, non-cultured epidermal cell suspension (NCES) has proven to be an effective and most accepted technique because of its advantage of treating large areas. This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/jdv.15502DOI Listing
February 2019

Fluorescence-Advanced Videodermatoscopy: A promising and potential technique for the in vivo evaluation of vitiligo.

Dermatol Ther 2019 Feb 14:e12863. Epub 2019 Feb 14.

Division of Dermatology, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.

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http://dx.doi.org/10.1111/dth.12863DOI Listing
February 2019

Mechanism of action of 4-substituted phenols to induce vitiligo and anti-melanoma immunity.

Pigment Cell Melanoma Res 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology and Netherlands Institute for Pigment Disorders, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam Infection& Immunity Institute, Cancer Center Amsterdam, Amsterdam, the Netherlands.

Monobenzone is a 4-substituted phenol that can induce vitiligo and antimelanoma immunity. We investigated the influence of the chemical structure on the biological activity of a series of structurally-related 4-substituted phenols. All phenols inhibited cellular melanin synthesis, and eight of ten phenols inhibited tyrosinase activity, using the MBTH assay. Read More

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http://dx.doi.org/10.1111/pcmr.12774DOI Listing
February 2019

Comparative evaluation of cytotoxic, antimicrobial and antioxidant activities of the crude extracts of three species grown in Saudi Arabia.

Saudi Pharm J 2019 Feb 25;27(2):162-170. Epub 2018 Sep 25.

Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.

Natural products from medicinal plants represent major resource of novel therapeutic substances for combating serious diseases including cancers and microbial infections. The genus (Family: Labiatae) represents a large and widespread group of species with a diversity of traditional uses in treatment of various ailments. Therefore, this research study aimed to evaluate the cytotoxic, antimicrobial and antioxidant activities of three species growing in Saudi Arabia namely Hocst. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13190164183034
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http://dx.doi.org/10.1016/j.jsps.2018.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362157PMC
February 2019
5 Reads

Cross cultural validation of a short-form of the Vitiligo Impact Patient scale (VIPs).

J Am Acad Dermatol 2019 Feb 11. Epub 2019 Feb 11.

FIMARAD, Hôpital Necker-Enfants Malades, APHP, Paris, France.

Background: there is a lack for short forms questionnaire evaluating the burden of Vitiligo according to skin phototype OBJECTIVE: To develop and validate a 12-item short-form of the Vitiligo Impact Patient Scale (VIPs) that takes into account skin phototype.

Methods: Multicentric, prospective, cross-sectionnal study conducted in France (Créteil and Bordeaux) and the US (Worcester, Massachusetts and Dallas, Texas).

Results: In total, 891 patients completed the questionnaire. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.02.008DOI Listing
February 2019

The role of IFIH1 gene rs1990760 and rs2111485 single-nucleotide polymorphisms in generalized vitiligo predisposition

Turk J Med Sci 2019 Feb 11;49(1):206-211. Epub 2019 Feb 11.

Background/aim: Interferon-induced helicase (IFIH1) is a gene locus that has been recently defined as a candidate for susceptibility to generalized vitiligo (GV). The objectives of this study were to assess the association of IFIH1 gene, rs2111485, and rs1990760 single-nucleotide polymorphisms (SNP) with susceptibility to GV and the autoimmune diseases accompanying GV.

Materials And Methods: We prospectively studied GV patients and frequency-matched healthy controls by age and sex. Read More

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http://dx.doi.org/10.3906/sag-1808-63DOI Listing
February 2019

Evaluation of different factors influencing objective measurement of skin color by colorimetry.

Skin Res Technol 2019 Feb 13. Epub 2019 Feb 13.

Department of Dermatology and Venereology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Background: Objective determination of skin color has become an essential requirement in managing pigmentary disorders including vitiligo. The readings of available devices can be influenced by factors such as surrounding temperature, vasodilation/constriction, and skin surface properties. Our aim was to investigate the influence of hair color and length, skin stretching, incomplete contact of the device with the skin, and the pressure with which the device is applied to the test area on skin color determination. Read More

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http://dx.doi.org/10.1111/srt.12680DOI Listing
February 2019

Efficacy of combined radiotherapy and anti-programmed death 1 therapy in acral and mucosal melanoma.

J Dermatol 2019 Feb 13. Epub 2019 Feb 13.

Department of Dermatology, Sapporo Medical University School of Medicine, Sapporo, Japan.

Some studies showed that clinical response to immune check point inhibitors is lower in acral and mucosal melanoma than in cutaneous melanoma. Although the synergistic effect of radiotherapy (RT) and ipilimumab has been reported in patients with brain metastasis, the efficacy of combined RT and anti-programmed death 1 (PD-1) therapy for acral and mucosal melanoma is unclear. The present study aimed to evaluate the efficacy of combined RT and anti-PD-1 therapy for acral and mucosal melanoma. Read More

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http://dx.doi.org/10.1111/1346-8138.14805DOI Listing
February 2019

Multiple paradoxical reactions during ixekizumab therapy.

Dermatol Ther 2019 Feb 12:e12852. Epub 2019 Feb 12.

Institute of Dermatology, Catholic University - Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

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http://doi.wiley.com/10.1111/dth.12852
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http://dx.doi.org/10.1111/dth.12852DOI Listing
February 2019
5 Reads

Atypical Pattern of Choroidal Hypopigmentation with Cutaneous Vitiligo.

Korean J Ophthalmol 2019 Feb;33(1):99-100

Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.3341/kjo.2018.0054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372386PMC
February 2019

A case of vitiligo cured with cucumber and sulfur.

Phytother Res 2019 Feb 11. Epub 2019 Feb 11.

Shanghai University of Sport, Shanghai, China.

This study investigates a 42-year-old man who used sulfur powder adhered to cucumber slices to successfully self-treat a vitiligo condition. The treatment has resulted in no recurrence of the disease for 21 years. We analyzed the mechanism of this folk prescription for vitiligo, concluding that the success of the self-treatment may be mainly associated with hydrogen sulfide (H S). Read More

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http://dx.doi.org/10.1002/ptr.6309DOI Listing
February 2019

Successful Treatment of Vitiligo Vietnamese Patients with Vitilinex® Herbal Bio-Actives in Combination with Phototherapy.

Open Access Maced J Med Sci 2019 Jan 29;7(2):283-286. Epub 2019 Jan 29.

University of Rome G. Marconi, Rome, Italy.

Background: Vitiligo is an acquired pigmentary disease, that causes progressive loss of melanocytes, resulting in hypopigmented skin patches. Current treatments aim at stopping the disease progression and achieving repigmentation of the amelanotic areas. Corticosteroids, surgery, topical immunomodulators, total depigmentation of normal pigmented skin and phototherapy are current treatment options for vitiligo although phototherapy remains the treatment of choice. Read More

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http://dx.doi.org/10.3889/oamjms.2019.095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364738PMC
January 2019

The Decline of PUVA Therapy in Vietnam: Effective Treatment of Narrow Band UVB in Vietnamese Vitiligo Patients.

Open Access Maced J Med Sci 2019 Jan 28;7(2):256-258. Epub 2019 Jan 28.

University of Rome G. Marconi, Rome, Italy.

Aim: To examine the efficacy and safety of Narrowband ultraviolet B (NB-UVB) in Vietnamese vitiligo patients.

Methods: We recruited thirty-one patients (14 males, 17 females), aged from 7 to 67 years, with both segmental vitiligo (SV) and non-segmental vitiligo (NSV), treated three times weekly with NB-UVB. The starting dose for adults from 15 years old and children less than 15 years old was 200 mJ/cm and 150 mJ/cm, respectively, with 50 mJ/cm and 20 mJ/cm dose increments at each subsequent visit, respectively, until mild erythema lasting less than 24 hrs reported by patient, given for a period of 6 months. Read More

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http://dx.doi.org/10.3889/oamjms.2019.068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364711PMC
January 2019
1 Read

Vietnamese Dermatology.

Open Access Maced J Med Sci 2019 Jan 28;7(2):179-180. Epub 2019 Jan 28.

University of Rome G. Marconi, Rome, Italia.

Background: The World Health Academy of Dermatology, the Vitiligo Research Foundation, the Military Medical Academy of Belgrade Serbia, the University of Parma-Italy and the University of Rome Guglielmo Marconi, Rome-Italy have successfully joined Vietnamese Dermatology Community in the ambitious project of positionìng Vietnam in the Dermatologic Olympus.

Aim: The aim of our special issue is to present some pearls of the Vietnamese Dermatology devoted to the description of the national and hopefully international declining of traditional therapies.

Methods: We present 36 contributions from all academic hospitals of Vietnam reflecting the therapeutic strategies and every day's dermato-venereology practice in Vietnam. Read More

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http://dx.doi.org/10.3889/oamjms.2019.131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364737PMC
January 2019

Efficacy of Microneedling and Photodynamic Therapy in Vitiligo.

Dermatol Surg 2019 Feb 6. Epub 2019 Feb 6.

Dermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.

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http://dx.doi.org/10.1097/DSS.0000000000001816DOI Listing
February 2019

Clinimetric analysis of recently applied quantitative tools in evaluation of vitiligo treatment.

Indian J Dermatol Venereol Leprol 2019 Feb 6. Epub 2019 Feb 6.

Dermatologist at Ministry of Health Hospital, Cairo, Egypt.

Background: Vitiligo affects about 1% of the world's population, however, there is currently no universally used standardized measure to assess its response to treatment.

Objective: To find the most effective technique for the quantitative assessment of therapeutic results in vitiligo patients.

Materials And Methods: The study was performed in three stages: (1) Conducting an adapted Delphi survey to check current dermatologists' attitudes regarding the topic of study. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_63_17DOI Listing
February 2019

Follicular vitiligo: dermatoscopic features of a new subtype of vitiligo.

An Bras Dermatol 2019 Jan-Feb;94(1):120-121

Department of Dermatology, Clínica Alemana, Universidad del Desarrollo, Santiago, Chile.

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http://dx.doi.org/10.1590/abd1806-4841.20198086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360965PMC
January 2018

Treatment of Refractory Vitiligo With a Vellus Hair Punch Graft.

Dermatol Surg 2019 Feb;45(2):300-303

Department of Dermatology, Inha University School of Medicine, Incheon, Republic of Korea.

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http://dx.doi.org/10.1097/DSS.0000000000001526DOI Listing
February 2019

Perspectives of New Advances in the Pathogenesis of Vitiligo: From Oxidative Stress to Autoimmunity.

Med Sci Monit 2019 Feb 6;25:1017-1023. Epub 2019 Feb 6.

Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China (mainland).

Vitiligo is an autoimmune cutaneous disease in which melanocytes are destroyed by CD8⁺ T cells resulting in disfiguring white spots. From the very beginning of the disease, oxidative stress plays a significant role in promoting the onset of vitiligo, as noted by many studies. Multiple factors lead to the overproduction of reactive oxygen species (ROS), and collaboratively cause ROS accumulation in vulnerable melanocytes. Read More

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https://www.medscimonit.com/abstract/index/idArt/914898
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http://dx.doi.org/10.12659/MSM.914898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373225PMC
February 2019
2 Reads

High incidence of MTHFR, CBS, and MTRR polymorphisms in vitiligo patients. Preliminary report in a retrospective study.

Eur Rev Med Pharmacol Sci 2019 Jan;23(2):471-478

Pathological Anatomy, Pineta Grande Hospital, Castel Volturno, Caserta, Italy.

Objective: Vitiligo is a multifactorial polygenic disorder with a complex pathogenesis. It is related to both genetic and no genetic factors. The role of genetics is currently studied with several analytical approaches, such as genetic linkage, candidate gene association studies, genome-wide association studies (GWAS), deep DNA re-sequencing and gene expression studies. Read More

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http://www.europeanreview.org/article/16858
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http://dx.doi.org/10.26355/eurrev_201901_16858DOI Listing
January 2019
3 Reads

T-cell responses against 4-tertiarybutylphenol-exposed pigmented cells in a patient with occupational vitiligo.

Br J Dermatol 2019 Feb 5. Epub 2019 Feb 5.

Department of Dermatology and Netherlands Institute for Pigment Disorders, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam Infection& Immunity Institute, Cancer Center Amsterdam, Amsterdam, Netherlands.

Several case studies on contact/occupational vitiligo after skin contact with 4-tertiairybutylphenol (4-TBP) have been reported. Biochemical and cellular effects of 4-TBP on melanocytes have been shown in vitro, but immunological analyses explaining the immunising ability of 4-TBP leading to wide-spread vitiligo lesions beyond areas of primary contact are still lacking. We report here the presence of a systemic T-cell response to 4-TBP-exposed pigmented cells in a patient with chemically-induced vitiligo. Read More

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http://dx.doi.org/10.1111/bjd.17713DOI Listing
February 2019

Specific Cytotoxic Effects of Parasporal Crystal Proteins Isolated from Native Saudi Arabian Strains against Cervical Cancer Cells.

Molecules 2019 Jan 31;24(3). Epub 2019 Jan 31.

Chair of Medical and Molecular Genetics Research, Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Saudi Arabia.

Currently, global efforts are being intensified towards the discovery of local (Bt) isolates with unique anticancer properties. Parasporins (PS) are a group of Bt non-insecticidal crystal proteins with potential and specific in vitro anticancer activity. However, despite the significant therapeutic potential of PS-producing Bt strains, our current knowledge on the effects of these proteins is limited. Read More

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http://www.mdpi.com/1420-3049/24/3/506
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http://dx.doi.org/10.3390/molecules24030506DOI Listing
January 2019
3 Reads
2.416 Impact Factor

Assessment of telomerase activity in nonsegmental vitiligo tissue: a pilot study.

Clin Exp Dermatol 2019 Jan 31. Epub 2019 Jan 31.

Department of Dermatology and Venereology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.

Background: Vitiligo is characterized by loss of melanocytes; therefore, an increased risk of photoageing and cancer are expected. However, a low incidence of cancer and sun damage in vitiliginous skin has been reported. Telomerase is a specialized cellular enzyme catalysing the synthesis of telomeres, and an increased level of the telomerase activity has been highlighted in most of human cancer cells and cancer cell lines. Read More

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http://doi.wiley.com/10.1111/ced.13892
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http://dx.doi.org/10.1111/ced.13892DOI Listing
January 2019
2 Reads

Mechanisms of repigmentation induced by photobiomodulation therapy in vitiligo.

Exp Dermatol 2019 Feb;28 Suppl 1:10-14

Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Photobiomodulation (PBM) therapy is based on the exposure of biological tissues to low-level laser light (coherent light) or light-emitting diodes (LEDs; noncoherent light), leading to the modulation of cellular functions, such as proliferation and migration, which result in tissue regeneration. PBM therapy has important clinical applications in regenerative medicine. Vitiligo is an acquired depigmentary disorder resulting from disappearance of functional melanocytes in the involved skin. Read More

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http://dx.doi.org/10.1111/exd.13823DOI Listing
February 2019
6 Reads

Vitiligo and thyroid disease: a systematic review and meta-analysis.

Eur J Dermatol 2018 Dec;28(6):750-763

Department of Dermatology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan, Departments of Dermatology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Vitiligo is associated with (autoimmune) thyroid disease. However, confounding factors, including type and onset of vitiligo, require elucidation. We conducted a meta-analysis to identify vitiligo patients with increased risk of (autoimmune) thyroid disease. Read More

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http://dx.doi.org/10.1684/ejd.2018.3449DOI Listing
December 2018
1 Read
1.990 Impact Factor

The Prevalence of Thyroid Disorders in Patients With Vitiligo: A Systematic Review and Meta-Analysis.

Front Endocrinol (Lausanne) 2018 15;9:803. Epub 2019 Jan 15.

Key Lab of Immunodermatology, Ministry of Health, Department of Dermatology, The First Hospital of China Medical University, Shenyang, China.

Associations between vitiligo and thyroid disorders have been suggested, However, the prevalence of thyroid disorders in vitiligo vary widely. To conduct a systematic review and meta-analysis assessing the prevalence of thyroid disorders in patients with vitiligo. The PubMed, Cochrane Library, EMBASE, CNKI (China National Knowledge Infrastructure), Chongqing VIP database, and Wanfang database from inception to August 2, 2018 were systematically searched. Read More

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http://dx.doi.org/10.3389/fendo.2018.00803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340922PMC
January 2019
1 Read

Hypo-pigmented mycosis fungoides is a rare malignancy in pediatrics.

Dermatol Online J 2018 Nov 15;24(11). Epub 2018 Nov 15.

Hematology Research Center, Shiraz University of Medical Sciences, Shiraz.

Hypopigmented mycosis fungoides (HMF) is an uncommon form of cutaneous T-cell lymphoma. It can be seen in children and is usually mistaken for eczema, vitiligo, or progressive macular hypomelanosis, clinically and histopathologically. We present a boy with HMF confirmed by histopathology. Read More

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November 2018
5 Reads

Onychomatricoma in a Patient with Extensive Vitiligo: Answer.

Am J Dermatopathol 2019 Feb;41(2):159-160

Department of Dermatology, Texas Tech University Health Sciences Center, Lubbock, TX.

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http://dx.doi.org/10.1097/DAD.0000000000000966DOI Listing
February 2019
4 Reads
1.426 Impact Factor

The Evaluation of Vitiligous lesions Repigmentation after the Administration of Atorvastatin calcium salt and Simvastatin-acid sodium salt in patients with active vitiligo (EVRAAS), a pilot study: study protocol for a randomized controlled trial.

Trials 2019 Jan 25;20(1):78. Epub 2019 Jan 25.

The Department of Dermatology, Sexually Transmitted Diseased and Immunodermatology, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland.

Background: Vitiligo is a chronic skin disorder presenting with depigmentation, the pathogenesis of which is complex but the autoimmune theory is now preferred. Multiple immunologic processes, including stimulation of the T-helper (Th)1 response, formation of autoreactive melanocyte-specific CD8 T lymphocytes, a decrease in the blood concentration of T regulatory (Treg) cells, and an increase in interleukin (IL)-17 and interferon (IFN) concentration, have been shown to contribute to vitiligo progression and maintenance. The aim of this study is to evaluate the influence of simvastatin and atorvastatin on vitiligous lesions in patients with nonsegmental vitiligo (NSV). Read More

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http://dx.doi.org/10.1186/s13063-018-3168-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346543PMC
January 2019
4 Reads

Comparison of 311-nm Titanium:Sapphire laser and 308-nm excimer laser treatment for vitiligo: A randomized controlled non-inferiority trial.

Lasers Surg Med 2019 Jan 25. Epub 2019 Jan 25.

Department of Dermatology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.

Objectives: The 308-nm excimer laser (EL) has been widely used for localized vitiligo. The recently developed Titanium:Sapphire laser, emits a wavelength of 311 nm, would be expected to be as effective as excimer laser in treatment of vitiligo but few controlled trials have been reported. We sought to compare the efficacy and safety of the TSL and EL as vitiligo treatments. Read More

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http://dx.doi.org/10.1002/lsm.23048DOI Listing
January 2019

New insights in vitiligo treatments using bioactive compounds from .

Exp Ther Med 2019 Feb 16;17(2):1039-1044. Epub 2018 Nov 16.

Medical and Pharmaceutical Research Unit, 'Research Centre in the Field of Medical and Pharmaceutical Sciences', Faculty of Medicine, Department of Pharmacy/Pharmacology Sciences, 'Dunărea de Jos' University of Galați, Galați 800101, Romania.

Although vitiligo is one of the most frequently occurring depigmentary disorder, its pathophysiology is still not fully clarified, resulting in the incapacity to find a targeted cure. Most of the treatment options available at the time have an anti-inflammatory or immunosuppressive effect, influencing the immune factor in vitiligo but without having a direct effect on melanocyte differentiation, migration or proliferation. This study shows that (PN) extract and its main alkaloid, piperine, promote melanocyte proliferation , being consistent with previous study. Read More

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http://dx.doi.org/10.3892/etm.2018.6977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327422PMC
February 2019

Alopecia areata in Tunisia: epidemio-clinical aspects and comorbid conditions. A prospective study of 204 cases.

Int J Dermatol 2019 Jan 24. Epub 2019 Jan 24.

Dermatology Department, Farhat Hached University Hospital, Sousse, Tunisia.

Background: Alopecia areata (AA) is an autoimmune condition that usually presents as patchy, nonscarring hair loss. Autoimmune disorders and atopy are reported as comorbid conditions. We aimed to investigate the demographics, clinical characteristics, and associations of AA in Tunisian patients. Read More

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http://dx.doi.org/10.1111/ijd.14381DOI Listing
January 2019
2 Reads

Quality of life of adult vitiligo patients using camouflage: A survey in a Chinese vitiligo community.

PLoS One 2019 24;14(1):e0210581. Epub 2019 Jan 24.

Department of Dermatology, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China.

Background: Vitiligo is an acquired depigmented skin disease resulting in white macules, which may significantly impair the quality of life (QoL) of the patients.

Objective: To estimate the QoL in Chinese vitiligo patients using camouflage with a more detailed description, and to identify the possible risk factors related to poor QoL.

Methods: An online survey was conducted in vitiligo patients using camouflage from a vitiligo community. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210581PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345473PMC
January 2019

Early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expression.

Nat Commun 2019 01 23;10(1):391. Epub 2019 Jan 23.

Human Medical Genetics and Genomics Program, University of Colorado School of Medicine, Aurora, 80045, CO, USA.

Vitiligo is an autoimmune disease in which melanocyte destruction causes skin depigmentation, with 49 loci known from previous GWAS. Aiming to define vitiligo subtypes, we discovered that age-of-onset is bimodal; one-third of cases have early onset (mean 10.3 years) and two-thirds later onset (mean 34. Read More

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http://dx.doi.org/10.1038/s41467-019-08337-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344500PMC
January 2019
1 Read
10.742 Impact Factor

Pembrolizumab resolves adult ashy dermatosis developing in patients with squamous cell carcinoma of the lung.

J Dermatol 2019 Jan 21. Epub 2019 Jan 21.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Ashy dermatosis is a rare cutaneous disorder of unknown etiology. We describe a case of adult ashy dermatosis developing in a patient with squamous cell carcinoma of the lung, which was resolved by the administration of pembrolizumab in parallel with multiple vitiligo. Interestingly, immunohistochemical staining revealed that lesional skin of the ashy dermatosis contained cytotoxic T cells and programmed death ligand 1 expressing cells. Read More

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http://dx.doi.org/10.1111/1346-8138.14775DOI Listing
January 2019
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The 308-nm excimer laser stimulates melanogenesis via the wnt/β-Catenin signaling pathway in B16 cells.

J Dermatolog Treat 2019 Jan 21:1-5. Epub 2019 Jan 21.

a Department of Dermatology , People's Hospital of Guangxi Zhuang Autonomous Region , Nanning , PR China.

Background: The mechanism of the 308-nm excimer laser in vitiligo treatment has not yet been adequately studied. In this study, we explored the role of the 308-nm excimer laser in treatment of vitiligo and the molecular mechanisms underlying melanin biosynthesis in melanocytes after 308-nm excimer laser radiation.

Materials And Methods: The B16 cells were irradiated at doses of 0 mJ/cm, 100 mJ/cm, 300 mJ/cm and 600 mJ/cm using a 308-nm excimer laser and then cultured for an additional 24, 48 or 72 hours. Read More

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http://dx.doi.org/10.1080/09546634.2019.1572861DOI Listing
January 2019

Association of glucose 6-phosphate dehydrogenase (G6PD) 3'UTR polymorphism with vitiligo and in vitro studies on G6PD inhibition in melanocytes.

J Dermatol Sci 2018 Dec 23. Epub 2018 Dec 23.

Department of Biochemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara 390002, Gujarat, India. Electronic address:

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http://dx.doi.org/10.1016/j.jdermsci.2018.12.001DOI Listing
December 2018
2 Reads
3.419 Impact Factor

Circulating CCL20: A potential biomarker for active vitiligo together with the number of Th1/17 cells.

J Dermatol Sci 2019 Jan 3. Epub 2019 Jan 3.

Department of Dermatology, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Road, Shanghai, 200040, PR China. Electronic address:

Background: Vitiligo is an autoimmune disease with varying pathological features. Activation of the CCL20-CCR6 axis plays an important role in chronic inflammatory diseases. However, whether CCL20-CCR6 and Th1/17 cells are indicative of active vitiligo is unclear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09231811183045
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http://dx.doi.org/10.1016/j.jdermsci.2018.12.005DOI Listing
January 2019
7 Reads
3.419 Impact Factor