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    1 OF 132

    Stigmatization in dermatology with a special focus on psoriatic patients.
    Postepy Hig Med Dosw (Online) 2017 Dec;71(0):1115-1122
    Department of Dermatology, Venereology and Allergology, University of Medicine, Wroclaw, Poland.
    A stigma is currently defined as a discrediting mark, biological or social, that sets a person off from others and disrupts interactions with them. People who differ from social norms in some respect are often negatively labeled. A number of medical conditions are recognized at present as stigmatizing their sufferers and certain skin diseases are among them. Read More

    Opportunities for laser-assisted drug delivery in the treatment of cutaneous disorders.
    Semin Cutan Med Surg 2017 Dec;36(4):192-201
    Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
    Fractional laser-assisted drug delivery (LADD) is increasingly finding its way into clinical practice as a new means to enhance topical drug uptake and improve treatment of cutaneous disorders. To date, LADD has been used for a wide range of conditions, including photodamaged skin, neoplastic lesions, scars, cutaneous infections, and vitiligo as well as for topical anesthetic and aesthetic procedures. Substantiated by randomized controlled clinical trials, strong evidence is available for LADD's usefulness for photodynamic therapy (PDT), for which improved efficacy using laser-assisted photosensitizer treatment is established for actinic keratosis compared with conventional PDT. Read More

    The Prevalence and Odds of Depression in Patients with Vitiligo: a Meta-Analysis.
    J Eur Acad Dermatol Venereol 2017 Dec 9. Epub 2017 Dec 9.
    Department of Dermatology, The Chinese people's liberation army 404 hospital, Weihai, China, 264200.
    Objective: The objective of this study is to provide a pooled estimate of the prevalence and odds of depression in Vitiligo patients.

    Methods: A systematic literature search of Medline, Embase, and Cochrane library databases was conducted. The proportions and mean questionnaire values for depression were pooled according to different evaluation methods. Read More

    Screening and identification of differentially expressed serum proteins in patients with vitiligo using two‑dimensional gel electrophoresis coupled with mass spectrometry.
    Mol Med Rep 2017 Nov 27. Epub 2017 Nov 27.
    Department of Dermatology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
    In the clinic, vitiligo is characterized by two stages: Stable and progressive. The pathogenesis of vitiligo is still not clear. Here, we identified serum markers of vitiligo by screening for differentially expressed proteins in patients with vitiligo compared to healthy individuals. Read More

    Psoriasis, Vitiligo and Crohn's Disease Co-Existing in a Single Patient: A Variant Type of Multiple Autoimmune Syndrome?
    Ann Dermatol 2017 Dec 30;29(6):782-785. Epub 2017 Oct 30.
    Department of Dermatology, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.
    Multiple autoimmune syndrome (MAS) is a rare condition, in which at least three well-defined autoimmune diseases co-occur in a single patient. Although the pathogenesis of MAS remains poorly understood, genetic, immunological, hormonal, and environmental factors may all play a role. Although three classic subtypes of MAS are well known, several cases that could not be placed into any of these three categories have recently been reported. Read More

    Involvement of Different Genes Expressions during Immunological and Inflammatory Responses in Vitiligo.
    Crit Rev Eukaryot Gene Expr 2017 ;27(3):277-287
    Department of Bioscience and Biotechnology, Banasthali University, Rajasthan, India; Birla Institute of Technology and Science, Pilani, Rajasthan, India.
    Vitiligo is a condition of the skin distinguished by hypo-pigmentation. Etiology of this disorder is unknown, and several theories and mechanisms have been hypothesized. The inflammatory response in vitiligo is thought to be mediated by polymorphism in genes such as FOXP3, ACE, APE, GSTP1, TLR, SOD, CTLA-4, TAP/LMP gene cluster, etc. Read More

    Homeopathic Treatment of Vitiligo: A Report of Fourteen Cases.
    Am J Case Rep 2017 Dec 2;18:1276-1283. Epub 2017 Dec 2.
    International Academy of Classical Homeopathy, Alonissos, Greece.
    BACKGROUND Vitiligo, also known as leukoderma, is an autoimmune skin condition that results in the loss of melanin pigment. Vitiligo is not a rare condition but is difficult to treat and is associated with psychological distress. CASE REPORT A series of 14 cases of vitiligo are presented that were treated with individualized homeopathic remedies that were based on plant, animal, or mineral compounds. Read More

    Differential Expression of Nitric Oxide Synthase Isoforms nNOS and iNOS in Patients with Non-Segmental Generalized Vitiligo.
    Int J Mol Sci 2017 Nov 26;18(12). Epub 2017 Nov 26.
    Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, 98124 Messina, Italy.
    Nitric oxide (NO) is involved in several biological processes, but its role in human melanogenesis is still not well understood. Exposure to UVA and UVB induces nitric oxide production in keratinocytes and melanocytes through the activation of constitutive nitric oxide synthase, increasing tyrosinase activity and melanin synthesis, whereas inducible nitric oxide synthase over expression might be involved in hypopigmentary disorders. The aim of this study was to evaluate whether inducible nitric oxide synthase and neuronal nitric oxide synthase expression were modified in vitiligo skin compared to healthy controls. Read More

    Evaluation of treatment response to autologous transplantation of noncultured melanocyte/keratinocyte cell suspension in patients with stable vitiligo.
    An Bras Dermatol 2017 May-Jun;92(3):312-318
    Private clinic - Belo Horizonte (MG), Brazil.
    Background: Vitiligo is a chronic disease characterized by the appearance of achromic macules caused by melanocyte destruction. Surgical treatments with melanocyte transplantation can be used for stable vitiligo cases.

    Objectives: To evaluate treatment response to the autologous transplantation of noncultured epidermal cell suspension in patients with stable vitiligo. Read More

    Dermatologic manifestations of endocrine disorders.
    Transl Pediatr 2017 Oct;6(4):300-312
    The Ohio State University College of Medicine, Columbus, OH, USA.
    The skin serves as a window for clinicians to understand, diagnose, and monitor endocrine disease. Dermatologic manifestations of endocrinopathies contribute significantly to an individual's health and quality of life. In this review, we outline various disorders of the hypothalamic-pituitary axis, thyroid gland, pancreas, adrenal gland, and androgen axis as well as hereditary endocrine syndromes. Read More

    [Common variable immune deficiency lately revealed by gastrointestinal problems: about a case].
    Pan Afr Med J 2017 20;28:48. Epub 2017 Sep 20.
    Service d'Hépato-Gastro-Entérologie, CHU Ibn Rochd, Casablanca, Maroc.
    Common Variable Immune Deficiency (CVID) is rare. It is a constitutional deficit of humoral immunity characterized by recurrent bacterial infections and by increased frequency of tumors, autoimmune or granulomatous diseases. Gastrointestinal manifestations are very variable and sometimes reveal common variable immune deficiency. Read More

    An Isoxazole Chalcone Derivative Enhances Melanogenesis in B16 Melanoma Cells via the Akt/GSK3β/β-Catenin Signaling Pathways.
    Molecules 2017 Nov 28;22(12). Epub 2017 Nov 28.
    Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, Xinjiang, China.
    Plants or plant-derived products have been routinely used in several traditional medicine systems for vitiligo treatment. It is well-known that melanogenesis can be promoted by certain flavonoid compounds isolated from the traditional Uyghur medicinal plant, Kaliziri. Therefore, Chalcones, one class of flavonoid compounds, has become an interesting target for the development of anti-vitiligo agents. Read More

    Levels of oxidative damage and proinflammatory cytokines are enhanced in patients with active vitiligo.
    Free Radic Res 2017 Dec;51(11-12):986-994
    a Department of Pharmacology , Institute of Post Graduate Medical Education and Research , Kolkata , India.
    Vitiligo is an autoimmune depigmenting skin disease characterised by loss of melanocytes wherein oxidative stress is proposed to be the initial triggering factor with subsequent immune dysregulation. This study aimed to evaluate the relationship, if any, between the generation of reactive oxygen species (ROS), markers of oxidative damage and circulating cytokines in patients with active vitiligo. The generation of ROS in erythrocytes and neutrophils was significantly higher in patients with active vitiligo than healthy controls. Read More

    Increased risk of vitiligo following anti-TNF therapy: A 10-year population-based cohort study.
    J Invest Dermatol 2017 Nov 23. Epub 2017 Nov 23.
    Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea. Electronic address:
    Anti-tumor necrosis factor-alpha (anti-TNF) therapy is used to treat a wide range of chronic inflammatory conditions. However, there have been increasing reports of development of vitiligo and alopecia areata (AA) secondary to anti-TNF therapy. In this study, we investigated the risks of vitiligo and AA in patients with ankylosing spondylitis, Crohn's disease, or ulcerative colitis who were treated with or without anti-TNF therapy, using data from the Korean National Health Insurance Claims database from 2007 to 2016. Read More

    Vitiligo and Autoimmune Thyroid Disorders.
    Front Endocrinol (Lausanne) 2017 27;8:290. Epub 2017 Oct 27.
    Department of Surgical Sciences, "Sapienza" University of Rome, Rome, Italy.
    Vitiligo represents the most common cause of acquired skin, hair, and oral depigmentation, affecting 0.5-1% of the population worldwide. It is clinically characterized by the appearance of disfiguring circumscribed skin macules following melanocyte destruction by autoreactive cytotoxic T lymphocytes. Read More

    Meta-analysis of the association between NLRP1 polymorphisms and the susceptibility to vitiligo and associated autoimmune diseases.
    Oncotarget 2017 Oct 22;8(50):88179-88188. Epub 2017 Sep 22.
    Department of Dermatology, Central Hospital of Shengli Oil Field, Shandong, People's Republic of China.
    Genetic variants are linked to vitiligo and associated autoimmune diseases. We performed a meta-analysis to evaluate the effects of the rs12150220, rs2670660, and rs6502867 polymorphisms within the human NLR Family Pyrin Domain Containing 1 (NLRP1) gene. We initially identified 1,306 candidate articles through literature searches of Pubmed, WOS, Embase, CNKI, WANFANGI, Ovid, Scopus, and Cochrane in July 2017. Read More

    Instruments to assess stigmatization in dermatology.
    Postepy Hig Med Dosw (Online) 2017 Nov;71(0):901-905
    Department of Dermatology, Venereology and Allergology, University of Medicine, Wroclaw, Poland.
    Stigmatization is the assignment of negative perceptions to an individual because of a perceived difference from the population at large. Skin conditions are frequently the reason of social rejection with a consequent negative influence on the personal and social life of patients. The aim of the current study was to review the available instruments that can be successfully utilized to measure the stigmatization level among dermatological patients. Read More

    Network pharmacological mechanisms of Vernonia anthelmintica (L.) in the treatment of vitiligo: Isorhamnetin induction of melanogenesis via up-regulation of melanin-biosynthetic genes.
    BMC Syst Biol 2017 Nov 16;11(1):103. Epub 2017 Nov 16.
    Pharmacology department, School of Pharmacy, Shihezi University, Shihezi, 832002, China.
    Background: Vitiligo is a long-term skin disease characterized by the loss of pigment in the skin. The current therapeutic approaches are limited. Although the anti-vitiligo mechanisms of Vernonia anthelmintica (L. Read More

    Factors Associated with Development of Vitiligo in Patients with Halo Nevus.
    Chin Med J (Engl) 2017 Nov;130(22):2703-2708
    Department of Dermatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
    Background: Halo nevus (HN) has been shown to be associated with vitiligo, but no standard signs are currently available to identify HN patients at risk of vitiligo, and the relevant data obtained in previous studies are somewhat conflicting. This study aimed to identify factors affecting the presence of vitiligo in HN patients.

    Methods: We performed a retrospective study on consecutive patients with HN at the First Affiliated Hospital of Sun Yat-sen University between January 2011 and December 2016. Read More

    Methoxsalen-induced macular toxicity.
    Indian J Ophthalmol 2017 Nov;65(11):1243-1245
    Shri Bhagwan Mahavir Department of Vitreoretinal Services, Sankara Nethralaya, Chennai, Tamil Nadu, India.
    Psoralen compounds such as methoxsalen are photosensitizer agents used in conjunction with ultraviolet A (UVA) radiation exposure as photochemotherapy (Psoralens and ultraviolet-A therapy [PUVA therapy]) for certain epidermal skin disorders such as psoriasis and vitiligo. Methoxsalen has been shown to be associated with premature cataract formation by forming adducts with lens proteins following oral administration and subsequent UVA exposure. Hence, the use of UV-filtering glasses is recommended during PUVA therapy sessions. Read More

    Expression of Janus Kinase 1 in vitiligo & psoriasis before and after narrow band UVB: a case-control study.
    Arch Dermatol Res 2017 Nov 10. Epub 2017 Nov 10.
    , Cairo, Egypt.
    Janus kinases (JAKs) are non-receptor protein tyrosine kinases that are expressed in many tissues. Once the JAKs are activated, a cascade of further signaling events is triggered involving phosphorylation of selected receptor chain tyrosines, binding of signal transducer and activator of transcription (STAT) proteins and phosphorylation of these STATs. Due to their ability to selectively modulate immune function, targeted JAK inhibitors are promising candidates for some skin diseases such as psoriasis and atopic dermatitis. Read More

    Functionalized carbon quantum dots with dopamine for tyrosinase activity analysis.
    Anal Chim Acta 2017 Dec 28;995:99-105. Epub 2017 Sep 28.
    Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China. Electronic address:
    Tyrosinase (TYR) is a key enzyme in melanin biosynthesis and its activity is an important biomarker for dermatological disorders, such as vitiligo, melanoma and actinic damages. Sensitive assay for TYR activity is significant for basic and clinical research. In this work, a facile fluorescent assay for TYR activity based on dopamine functionalized carbon quantum dots (CQDs-Dopa) has been developed. Read More

    Impact of Ultraviolet Light on Vitiligo.
    Adv Exp Med Biol 2017 ;996:55-60
    David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, 90095, USA.
    Vitiligo is a disorder of the melanocytes that results in a dynamic spectrum of skin depigmentation. Its etiology is complex and multifactorial, with data supporting several different hypotheses. Given its prominent phenotype, vitiligo has a significant negative impact on quality of life. Read More

    Immunotherapy "Shock" with vitiligo due to nivolumab administration as third line therapy in lung adenocarcinoma.
    Respir Med Case Rep 2017 26;22:283-286. Epub 2017 Oct 26.
    Sana Clinic Group Franken, Department of Cardiology/Pulmonology/Intensive Care/Nephrology, "Hof'' Clinics, University of Erlangen, Hof, Germany.
    Non-small cell lung cancer is still diagnosed at late stage due to the lack of early symptoms and methods of diagnostic prevention. In the past ten years several targeted therapies have been introduced or explored. Tyrosine kinase inhibitors and immunotherapy are currently considered the most effective and safe therapies in comparison to the non-specific cytotoxic agents. Read More

    Comparison Between (311-312 nm) Narrow Band Ultraviolet-B Phototherapy and (308 nm) Monochromatic Excimer Light Phototherapy in Treatment of Vitiligo: A Histopathological Study.
    J Lasers Med Sci 2017 27;8(3):123-127. Epub 2017 Jun 27.
    Department of Dermatology and Venereology, National Research Centre, Giza, Egypt.
    Introduction: Recently, the monochromatic excimer light (MEL) of 308 nm wavelength has shown some advantages in comparison to narrow band ultraviolet B (NB-UVB) for the treatment of vitiligo. To histopathologically compare the early effects of NB-UVB and 308-nm MEL phototherapy on vitiliginous patches using H&E and HMB-45. Methods: Thirty subjects with non-segmental vitiligo lesions were treated twice a week for 6 weeks with 308-nm MEL, while NB-UVB was used to treat lesions contra laterally. Read More

    Association of Leukotrichia in Vitiligo and Asp148Glu Polymorphism of Apurinic/Apyrimidinic Endonuclease 1.
    Int J Trichology 2017 Oct-Dec;9(4):171-176
    Department of Biochemistry, Faculty of Medicine, Istanbul University, Istanbul, Turkey.
    Background: Oxidative stress and increased DNA damage have been implicated in the etiopathogenesis of vitiligo. Oxidative DNA damage is mainly repaired by the base excision repair (BER) pathway.

    Aim: We sought to determine whether polymorphisms in DNA repair genes may have a role in the pathogenesis of vitiligo. Read More

    Insignificant Correlation between Thyroid Hormone and Antithyroid Peroxidase Antibodies in Alopecia Areata Patients in Northern Rajasthan.
    Int J Trichology 2017 Oct-Dec;9(4):149-153
    Department of Dermatology, STDs and Leprosy, SMS Medical College, Jaipur, Rajasthan, India.
    Background: Alopecia areata (AA) is a common, recurrent form of nonscarring alopecia which often presents as circumscribed patches of spontaneous hair loss. The global prevalence of this disease varies from 0.1% to 0. Read More

    Role of chemokines and the corresponding receptors in vitiligo: A pilot study.
    J Dermatol 2017 Nov 8. Epub 2017 Nov 8.
    Dermatology, The Third People's Hospital of Hangzhou, Hangzhou, China.
    To determine the levels and sources of chemokines in the serum and epidermis of vitiligo patients, we examined 80 active patients, 80 stable patients and 40 healthy controls. First, the serum levels of candidate chemokines were measured by Luminex assay, and levels of CCR5, CXCR1 and CXCR3 were measured in peripheral mononuclear cells (PMBC) by flow cytometry. Then, the local epidermis levels of elevated chemokines in vitiligo were tested by Luminex. Read More

    Fractional Carbon Dioxide Laser as an "Add-on" Treatment for Vitiligo: A Meta-analysis with Systematic Review.
    Acta Derm Venereol 2017 Nov 7. Epub 2017 Nov 7.
    Department of Preventive Medicine, Korea University College of Medicine, Seoul, Korea.
    Treatment of vitiligo is challenging and requires a multidisciplinary approach. Fractional carbon dioxide (CO2) laser as an add-on to conventional treatment has been reported to be effective, but there is no consensus on its use. A systematic review was performed by searching major databases for relevant publications to February 2017. Read More

    A single-arm open-label clinical trial of autologous epidermal cell transplantation for stable vitiligo: A 30-month follow-up.
    J Dermatol Sci 2017 Oct 18. Epub 2017 Oct 18.
    Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran. Electronic address:
    Background: Recently, we introduced intralesional injection of autologous epidermal cells as a safe and feasible approach for transplantation in patients with stable vitiligo. This approach resulted in less pain during and after the procedure, no scarring or cobblestone formation at the recipient site, and was more feasible to perform on curved surfaces such as joints, lips, eyelids, ears, and face.

    Objective: In this study, we aimed to investigate the long-term efficacy and safety of this transplantation technique. Read More

    Acute-onset type 1 diabetes mellitus caused by nivolumab in a patient with advanced pulmonary adenocarcinoma.
    J Diabetes Investig 2017 Nov;8(6):798-799
    Department of Endocrinology and Metabolism, Tsukuba University Hospital Mito Clinical Education and Training Center, Mito Kyodo General Hospital, Mito, Ibaraki, Japan.
    A case of acute-onset type 1 diabetes mellitus concomitant with pneumonitis and vitiligo is described. Read More

    Study of the relation between two common cyclooxygenase 2 gene polymorphisms with risk of developing and subtypes of vitiligo in Egyptian patients.
    Indian J Dermatol Venereol Leprol 2017 Nov 1. Epub 2017 Nov 1.
    Department of Dermatology and Venereology, National Research Centre, Giza, Egypt.
    Background/purpose: Genetic factors play an important role in the pathogenesis of vitiligo. Cyclooxygenase 2 (COX2) gene induced by ultraviolet radiation controls the synthesis of prostaglandins, which are are found to be beneficial in treating vitiligo. COX2 gene polymorphism has been previously evaluated in Chinese population. Read More

    CXCL-10 and Interleukin-6 are reliable serum markers for vitiligo activity: A multicenter cross-sectional study.
    Pigment Cell Melanoma Res 2017 Nov 1. Epub 2017 Nov 1.
    Dermatology Department, Cairo University, Cairo, Egypt.
    This cross-sectional multicenter study aimed to evaluate serum CXCL-10, as an activity marker for vitiligo, and compare it with other putative serum and tissue markers. Serum CXCL-10 was compared to interferon gamma (IFN-γ), interleukin 6 (IL-6), and IL-17 using ELISA in 55 non-segmental vitiligo patients (30 active and 25 stable) and 30 healthy controls. Marginal skin biopsy was taken for immunohistochemical evaluation of CD8+T cells and CXCL-10+ve cells. Read More

    Immune-Related Adverse Events Associated with Anti-PD-1/PD-L1 Treatment for Malignancies: A Meta-Analysis.
    Front Pharmacol 2017 18;8:730. Epub 2017 Oct 18.
    Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
    Background: Treatment of cancers with programmed cell death protein 1 (PD-1) pathway inhibitors can lead to immune-related adverse events (irAEs), which could be serious and even fetal. Therefore, clinicians should be aware of the characteristics of irAEs associated with the use of such drugs. Methods: The MEDLINE, EMBASE, and Cochrane databases were searched to find potential studies using the following strategies: anti-PD-1/PD-L1 treatment; irAEs; and cancer. Read More

    Congenital vitiligo: A case observed in the cohort of HIV-exposed infants in Bobo-Dioulasso, Burkina Faso.
    Pediatr Rep 2017 Oct 6;9(3):7300. Epub 2017 Oct 6.
    Department of Pediatrics, and.
    Vitiligo is a dermatological disease; its exact prevalence is unknown among the paediatric population. We are reporting a case of vitiligo at birth for the first time in Burkina Faso, in the Teaching Hospital Souro Sanou of Bobo-Dioulasso, Paediatric Department. He is a male child, born from HIV-1 positive parents; we received him when he was 2 months to be followed in connection with the prevention of motherto-child transmission. Read More

    The MeLiM Minipig: An Original Spontaneous Model to Explore Cutaneous Melanoma Genetic Basis.
    Front Genet 2017 13;8:146. Epub 2017 Oct 13.
    LREG, CEA, Université Paris-Saclay, Jouy-en-Josas, France.
    Melanoma is the deadliest skin cancer and is a major public health concern with a growing incidence worldwide. As for other complex diseases, animal models are needed in order to better understand the mechanisms leading to pathology, identify potential biomarkers to be used in the clinics, and eventually molecular targets for therapeutic solutions. Cutaneous melanoma, arising from skin melanocytes, is mainly caused by environmental factors such as UV radiation; however a significant genetic component participates in the etiology of the disease. Read More

    Narrow-band UVB effects on cutaneous vitamin D receptor expression and serum 25-hydroxyvitamin D in generalized vitiligo.
    Photodermatol Photoimmunol Photomed 2017 Oct 28. Epub 2017 Oct 28.
    Department of Biochemistry and molecular biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
    Background/purpose: Vitamin D has a role in variety of autoimmune diseases including vitiligo. Narrow-band UVB (NB-UVB) treatment of vitiligo might act through its effects on vitamin D and its receptor.This study is the first to elucidate NB-UVB effects on immunohistochemical vitamin D receptor (VDR) expression in generalized vitiligo and correlate it with serum vitamin D and repigmentation response. Read More

    Dermoscopy in vitiligo: diagnosis and beyond.
    Int J Dermatol 2017 Oct 26. Epub 2017 Oct 26.
    Department of Skin & V.D Patna Medical College & Hospital, Patna, Bihar, India.
    Background: Vitiligo is essentially a clinical diagnosis, and dermoscopy may aid in noninvasive confirmation of diagnosis by excluding other clinically simulating hypopigmentary conditions. More importantly, dermoscopy is rapidly gaining ground as an important adjunct tool to evaluate disease activity.

    Aim: To study the dermoscopic features of vitiligo and ascertain their correlation with disease activity. Read More

    Generalized eruptive keratoacanthoma with vitiligo followed by the development of prurigo nodularis: A case report and published work review.
    J Dermatol 2017 Oct 23. Epub 2017 Oct 23.
    Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
    Herein, we report a unique case of generalized eruptive keratoacanthoma (GEKA) in a 47-year-old Chinese man presenting with extensive pruritic papules and nodules accompanied by oral lesions. He also had a 2-year history of vitiligo and long-term experience of working outdoors. Biopsies were consistent with keratoacanthoma . Read More

    Energetic mitochondrial failing in vitiligo and possible rescue by cardiolipin.
    Sci Rep 2017 Oct 20;7(1):13663. Epub 2017 Oct 20.
    Cutaneous Physiopathology Lab, San Gallicano Dermatologic Institute, IFO IRCCS Rome, via Elio Chianesi, 53 00144, Italy.
    Vitiligo is characterized by death or functional defects of epidermal melanocytes through still controversial pathogenic process. Previously, we showed that mitochondria-driven pre-senescent phenotype diminishes the capability of vitiligo melanocytes to cope with stressful stimuli. In the current study, we investigated markers of mitochondrial energy metabolism including the PGC1a axis, and then we determined the index of mitochondrial impairment using a cytomic approach. Read More

    Spectrophotometer is useful for assessing vitiligo and chemical leukoderma severity by quantifying color difference with surrounding normally pigmented skin.
    Skin Res Technol 2017 Oct 22. Epub 2017 Oct 22.
    Department of Dermatology, Yamagata University Faculty of Medicine, Yamagata, Yamagata, Japan.
    Background: Acquired skin hypopigmentation has many etiologies, including autoimmune melanocyte destruction, skin aging, inflammation, and chemical exposure. Distinguishing lesions from normally pigmented skin is clinically important to precisely assess disease severity. However, no gold standard assessment method has been reported. Read More

    Repigmentation of Human Vitiligo Skin by NBUVB is Controlled by Transcription of GLI1 and Activation of β-Catenin Pathway in the Hair Follicle Bulge Stem Cells.
    J Invest Dermatol 2017 Oct 17. Epub 2017 Oct 17.
    Department of Dermatology, University of Colorado, Aurora, CO, USA; Gates Center for Regenerative Medicine, University of Colorado Aurora, CO, USA.
    Vitiligo repigmentation is a complex process in which the melanocyte-depleted interfollicular epidermis (IE) is repopulated by melanocyte precursors from hair follicle (HF) bulge that proliferate, migrate, and differentiate into mature melanocytes on their way to the epidermis. The strongest stimulus for vitiligo repigmentation is narrow band UVB (NBUVB), but how the HF melanocyte precursors are activated by UV light has not been extensively studied. To better understand this process, we developed an application that combined laser capture microdissection and subsequent whole transcriptome RNA sequencing of HF bulge melanocyte precursors, and compared their gene signature to that of regenerated mature epidermal melanocytes from the NBUVB-treated vitiligo skin. Read More

    Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells.
    Cancer Immunol Immunother 2017 Oct 20. Epub 2017 Oct 20.
    Department of Surgery, Loyola University Chicago, 2160 S. 1st Avenue, Maywood, IL, 60153, USA.
    Malignant melanoma incidence has been increasing for over 30 years, and despite promising new therapies, metastatic disease remains difficult to treat. We describe preliminary results from a Phase I clinical trial (NCT01586403) of adoptive cell therapy in which three patients received autologous CD4+ and CD8+ T cells transduced with a lentivirus carrying a tyrosinase-specific TCR and a marker protein, truncated CD34 (CD34t). This unusual MHC Class I-restricted TCR produces functional responses in both CD4+ and CD8+ T cells. Read More

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