8,232 results match your criteria Vitiligo

Prediction of Immune-Checkpoint Blockade Monotherapy Response in Patients With Melanoma Based on Easily Accessible Clinical Indicators.

Front Oncol 2021 27;11:659754. Epub 2021 May 27.

Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.

Background: Immune checkpoint blocker (ICB) has shown significant clinical activity in melanoma. However, there are no clinically approved biomarkers to aid patient selection. We aimed to identify patients with advanced or metastatic melanoma who are likely to benefit from ICB monotherapy using easily accessible clinical indicators. Read More

View Article and Full-Text PDF

What is the impact of thyroidectomy on autoimmune features associated with Hashimoto's thyroiditis?-Institutional experience.

Niger J Clin Pract 2021 Jun;24(6):905-910

Pinnamaneni Siddartha Institute of Medical Sciences (PSIMS), Gannavaram, Vijayawada, AP, India.

Background: Hashimoto's thyroiditis (HT) is one of the commonest endocrine disorders, globally. Often, HT presents a protean range of associated autoimmune features (AAI) such as vitiligo, rheumatoid arthritis, pernicious anemia, skin allergy/atopy, thrombocytopenia, Addison's disease, type 1 diabetes, celiac disease, eosinophilia, etc., The usual treatment of HT is symptomatic with no curative option. Read More

View Article and Full-Text PDF

Emerging role of Tissue Resident Memory T cells in vitiligo: From pathogenesis to therapeutics.

Autoimmun Rev 2021 Jun 10;20(8):102868. Epub 2021 Jun 10.

C. G. Bhakta Institute of Biotechnology, Uka Tarsadia University, Tarsadi, Surat 394350, Gujarat, India. Electronic address:

Vitiligo is an acquired depigmenting disorder which affects both skin and mucous membranes and autoimmunity has been strongly suggested to play a role in loss of melanocytes. The recurrence of skin macules at the same sites where they were observed prior to the treatment, suggests the existence of Tissue Resident Memory T cells (TRMs) that persist within the skin or peripheral tissues with a longer survivability. Emerging studies have shown that reactivation of these skin TRMs results into autoreactive TRM cells in various autoimmune diseases including vitiligo. Read More

View Article and Full-Text PDF

Prospective observational study of the efficacy of nivolumab in Japanese patients with advanced melanoma (CREATIVE study).

Jpn J Clin Oncol 2021 Jun 12. Epub 2021 Jun 12.

Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.

Background: Nivolumab, the anti-programmed cell death protein 1 antibody, has been approved for advanced melanoma, mainly based on evidence from Western countries. The profile of melanoma differs between Caucasian and Asian patients. This study was performed to obtain post-marketing data of nivolumab in Japanese patients with advanced melanoma. Read More

View Article and Full-Text PDF

A novel mouse model to evaluate neuropeptide Y-mediated melanocyte pathology.

Exp Dermatol 2021 Jun 11. Epub 2021 Jun 11.

Department of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.

Vitiligo is an autoimmune disease characterized by depigmented patches of skin due to loss of the pigment-producing melanocytes. No cure exists for vitiligo. The available treatments are inefficient for many patients, suggesting that universal treatment approaches may be inappropriate. Read More

View Article and Full-Text PDF

Validity and feasibility of the self-assessment vitiligo extent score among Egyptian patients.

Indian J Dermatol Venereol Leprol 2021 May 31:1-3. Epub 2021 May 31.

Departments of Dermatology, Venereology and Andrology, Faculty of Medicine, Ain Shams University Hospital, Abbassia, Cairo, Egypt.

View Article and Full-Text PDF

308nm excimer lamp monotherapy for lip vitiligo-a short case series.

Ajay J Deshpande

J Cosmet Laser Ther 2021 Jun 10:1-3. Epub 2021 Jun 10.

Dermatology, Maharashtra Medical Foundation, Joshi Hospital, Pune, India.

Vitiligo is a common depigmenting condition that carries a high psychosocial morbidity, especially when it occurs over exposed areas like lips. Many of the current topical and systemic therapies are less effective in lip vitiligo, and surgical modality remains the mainstay of treatment of lip vitiligo. The 308-nm excimer laser in combination with topical calcineurin inhibitors and calcipotriene is effective in the treatment of lip vitiligo. Read More

View Article and Full-Text PDF

Identification of TYR, TYRP1, DCT and LARP7 as related biomarkers and immune infiltration characteristics of vitiligo via comprehensive strategies.

Bioengineered 2021 Dec;12(1):2214-2227

Department of Dermatology, the First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.

This study aims to explore biomarkers associated with vitiligo and analyze the pathological role of immune cell infiltration in the disease. We used the robust rank aggregation (RRA) method to integrate three vitiligo data sets downloaded from gene expression omnibus database, identify the differentially expressed genes (DEGs) and analyze the functional correlation. Then, the comprehensive strategy of combined weighted gene coexpression network analysis (WGCNA) and logical regression of the selection operator (LASSO), support vector machine recursive feature elimination (SVM-RFE), and random forest (RF) machine learning algorithm are employed to screen and biomarkers associated with vitiligo. Read More

View Article and Full-Text PDF
December 2021

Vitiligo and chronic autoimmune thyroiditis.

J Med Life 2021 Mar-Apr;14(2):127-130

Department of Endocrinology, Clinical County Hospital, Cluj-Napoca, Romania.

Vitiligo, the discoloration of the skin, has different autoimmune mechanisms reflected by many biomarkers as shown by skin histology, staining for CD4 and CD8 T lymphocytes, chemokine ligand 9 or circulating cytokines such as interleukin (IL)-1 beta, interferon (IFN)-gamma, transforming growth factor (TGF)-beta, antibodies, markers of oxidative stress, chemokines, and others. In this narrative review, we aim to overview vitiligo in relationship with chronic autoimmune thyroiditis. Regarding vitiligo, more than 50 different genetic loci have been associated with this disease, and the heritability is high. Read More

View Article and Full-Text PDF

Dendritic cells and their associated pro-inflammatory cytokines augment to the inflammatory milieu in vitiligo skin.

Cytokine 2021 Jun 5:155598. Epub 2021 Jun 5.

Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

Background And Aim: Vitiligo is a progressive, autoimmune, hypomelanotic acquired disorder of skin which is characterized by depigmentation. The initial immunological events of this diseases are still at enigma that includes breach of immune tolerance, and defect in antigen presentation. Hence, we aimed to explore role of Dendritic cells (DCs) and its associated cytokines in the pathogenesis of generalized vitiligo (GV) patients. Read More

View Article and Full-Text PDF

RIP1-mediated necroptosis facilitates oxidative stress-induced melanocyte death offering insight into vitiligo.

J Invest Dermatol 2021 Jun 5. Epub 2021 Jun 5.

Department of Dermatology, Xijing hospital, Fourth Military Medical University, Xi'an, Shannxi, China. Electronic address:

Vitiligo is a common depigmentation disease characterized by the melanocyte death which is attributed to various mechanisms such as apoptosis and autoimmune destruction. However, whether necroptosis, a newly discovered way of cell death, plays a key role in the pathogenesis of vitiligo is still elusive has not been well studied. In this study, we found that necroptosis markers including phosphorylated receptor-interacting protein 3 (p-RIP3) and phosphorylated mixed lineage kinase domain-like protein (p-MLKL) were positive in melanocytes from vitiligo perilesional skins, which supported the existence of necroptosis in vitiligo. Read More

View Article and Full-Text PDF

The rationality involved in the popular use of coffee (Coffea sp) and sunflower seed (Helianthus annuus) for the treatment of vitiligo: a case report.

Explore (NY) 2021 May 24. Epub 2021 May 24.

Department of Pharmaceutical Products, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, Belo Horizonte, Minas Gerais, Brazil.

Introduction: Vitiligo is a dermatological disease that affects about 0.38% to 2.9% of the world population. Read More

View Article and Full-Text PDF

Updates and new medical treatments for vitiligo (Review).

Exp Ther Med 2021 Aug 25;22(2):797. Epub 2021 May 25.

Department of Dermatology, Faculty of Medicine and University Hospital 'Dr. José Eleuterio González', Universidad Autónoma de Nuevo León, Monterrey, Nuevo León 64460, México.

Vitiligo is a multifactorial disease characterized by the loss of skin pigment, which results in achromic macules and patches. There are currently several medical treatments available, which aim to arrest progression and induce skin repigmentation. These treatments alone or combined have exhibited varying degrees of pigmentation, and the majority are safe and effective. Read More

View Article and Full-Text PDF

The multi-target mechanism of Cyclosporin A in the treatment of vitiligo based on network pharmacology.

Dermatol Ther 2021 Jun 5:e15023. Epub 2021 Jun 5.

Department of Dermatology, The Third People's Hospital of Hangzhou, Zhejiang, Hangzhou, China.

Network pharmacology is an emerging discipline that designs drugs based on systems biology theory and biological system network analysis. Here, we applied network pharmacology to analyze the multi-target mechanism of Cyclosporin A in the treatment of vitiligo First, we predicted the targets of Cyclosporin A. Second, we obtained the genes related to vitiligo from the database. Read More

View Article and Full-Text PDF

Janus Kinase Inhibitors in Dermatology: Part 1 - General Considerations and Applications in Vitiligo and Alopecia Areata.

Actas Dermosifiliogr 2021 Jun 19;112(6):503-515. Epub 2021 Mar 19.

Servicio de Dermatología, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

Dermatologists' interest in the Janus-associated kinase/signal transducers and activators of transcription (JAK/STAT) pathway has been growing as evidence builds to support its key role in the pathogenesis of inflammatory skin diseases. Because certain proinflammatory cytokines use the JAK/STAT pathway for signal transduction, it has become a promising therapeutic target in diseases where selective modulation of the immune system can be useful. We aim to review current knowledge of the JAK/STAT signaling pathway and its role in immune-mediated skin diseases. Read More

View Article and Full-Text PDF

An Overview of Phytochemical and Biological Activities: Jack and Other spp.

J Pharm Bioallied Sci 2021 Jan-Mar;13(1):11-25. Epub 2020 Dec 25.

Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Cawangan Selangor, Kampus Puncak Alam, Selangor Darul Ehsan, Malaysia.

Jack (Moraceae) is a well-known medicinal plant used in customary medication among the Malay people to reduce and mend sicknesses such as ulcers, psoriasis, cytotoxicity, cardioprotective, inflammation, jaundice, vitiligo, hemorrhage, diabetes, convulsion, hepatitis, dysentery injuries, wounds, and stiffness. contains a wide variety of bioactive compounds from different phytochemical groups such as alkaloids, phenols, flavonoids, saponins, sterols, terpenes, carbohydrates, and proteins. The genus has several hundreds of species, which shows excellent therapeutic effects and a wide variety of helpful properties for human welfare. Read More

View Article and Full-Text PDF
December 2020

Innovative Technique for Securing Autologous Melanocyte-keratinocyte Cell Transplant (MKCT) Suspension in Stable Vitiligo.

J Cutan Aesthet Surg 2021 Jan-Mar;14(1):132-135

Department of Dermatology, Maharashtra Medical Foundation's Joshi Hospital, Pune, Maharashtra, India.

Autologous cultured melanocyte transplantation is a safe and effective cellular regenerative surgical treatment modality for the lesions of stable vitiligo. Research continues to improve the efficacy of cell transplants by refining the procedure. The method of dressing used to secure the cell suspension over the treated site is vital in deciding the extent of repigmentation. Read More

View Article and Full-Text PDF

Fractional Carbon Dioxide Laser versus Fractional Carbon Dioxide Laser with Autologous Intralesional Platelet-rich Plasma in the Treatment of Stable, Non-segmental Vitiligo: A Randomized Comparative Study.

J Cutan Aesthet Surg 2021 Jan-Mar;14(1):55-63

Department of DVL, Institute of Medical Sciences & SUM Hospital, Siksha O Anusandhan University, Bhubaneswar, Odisha, India.

Background: The treatment of vitiligo is often challenging and requires a multi-modality approach. Fractional carbon dioxide (FCO) laser has been studied as an adjuvant therapy in cases of vitiligo. Autologous platelet-rich plasma (PRP) is rich in growth factors, which may contribute to the growth of melanocytes, and thus help in the repigmentation of vitiligo patches. Read More

View Article and Full-Text PDF

Comparative Evaluation of Efficacy of Non-cultured Epidermal Cell Suspension and Epidermal Curettage in Stable Vitiligo.

J Cutan Aesthet Surg 2021 Jan-Mar;14(1):32-40

Department of Dermatology, Government Medical College, Amritsar, Punjab, India.

Context: Vitiligo is a common primary acquired pigmentary disorder due to loss of epidermal functioning melanocytes. Many surgical techniques have evolved over the years for its treatment and the need of a cost-effective modality has always been put forward.

Aim: The aim of the study was to compare the efficacy of non-cultured epidermal cell suspension with that of epidermal curettage in repigmentation of stable vitiligo. Read More

View Article and Full-Text PDF

Does autoimmune vitiligo protect against COVID-19 disease?

Exp Dermatol 2021 Jun 3. Epub 2021 Jun 3.

Department of Dermatology, University of Münster, Münster, Germany.

The SARS-CoV-2 pandemic has evolved to a global health problem with a dramatic morbidity and mortality rate impacting our daily life and those of many patients. While there is evidence that some diseases are associated with an increased risk for development of a more severe course of COVID-19, little is known on protective conditions. Importantly, clearance of viral infection and protection against disease manifestation crucially depends on functional innate and adaptive immunity and the interferon signalling axis. Read More

View Article and Full-Text PDF

Blood high mobility group box 1 levels are not a suitable biomarker for disease activity or severity in non-segmental vitiligo.

Clin Exp Dermatol 2021 Jun 3. Epub 2021 Jun 3.

Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

High mobility group box 1 (HMGB1) is one of intracellular damage associated molecular patterns which is released from keratinocytes in response to external stressors and affects neighboring melanocytes by inducing apoptosis and suppressing melanogenesis. HMGB1 levels in the blood and its expression in skin tissues are increased in psoriasis, alopecia areata, dystrophic epidermolysis bullosa, and vitiligo. Read More

View Article and Full-Text PDF

Epidemiology of Vitiligo - A Dual Population-Based Approach.

Clin Epidemiol 2021 26;13:373-382. Epub 2021 May 26.

Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.

Background: Most epidemiological data on vitiligo refer to selected environments or focus on the prevalence of comorbidity unrelated to the population.

Objective: Aim of the study was to gain robust representative prevalence data on vitiligo and on associated dermatologic comorbidity in the German adult population.

Methods: A dual population-based approach was applied with 1) primary data obtained between 2004 and 2014 from dermatological exams in the general working population; 2) claims data from a large German statutory health insurance, reference year 2010. Read More

View Article and Full-Text PDF

Nivolumab-Induced Alopecia Areata: A Case Report and Literature Review.

Ann Dermatol 2021 Jun 4;33(3):284-288. Epub 2021 May 4.

Department of Dermatology, Kyung Hee University School of Medicine, Seoul, Korea.

Nivolumab (anti-PD-1) currently used in many cancers. With the usage of nivolumab increased, many cutaneous side effects were reported including maculopapular rash, lichenoid reactions, vitiligo, bullous disorders, psoriasis exacerbation, and alopecia areata (AA). Here, we report AA after nivolumab for treatment of hepatocellular carcinomas (HCC). Read More

View Article and Full-Text PDF

Quality of life in vitiligo patients in central Saudi Arabia.

Saudi Med J 2021 Jun;42(6):682-687

From the Department of Family and Community Medicine (Al-Shammari), College of Medicine; from the College of Medicine (Alotaibi, Assiri, Altokhais, Alotaibi), King Saud University, Riyadh; and from the Department of Dermatology (Alkhowailed), College of Medicine, Qassim University, Buraidah, Qassim, Kingdom of Saudi Arabia.

Objectives: To assess the quality of life (QoL) in patients with vitiligo in central Saudi Arabia using the dermatology life quality index (DLQI).

Methods: A cross-sectional study spanning over 6 months was conducted on 253 adult patients with vitiligo at the outpatient dermatology clinics of the National Center of Vitiligo (Light Clinics) and King Khalid University Hospital, Riyadh, Saudi Arabia. The patients were asked to complete a self-administered questionnaire using an Arabic version of the DLQI to measure the impact of vitiligo on their QoL. Read More

View Article and Full-Text PDF

CCL17-CCR4 axis contributes to the onset of vitiligo in mice.

Immun Inflamm Dis 2021 Jun 2. Epub 2021 Jun 2.

Department of Dermatology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, China.

Background: Destruction of melanocytes mediated by autoimmunity is currently believed as the main cause of vitiligo. This article aims to identify the role of CC chemokine ligand 17 (CCL17)-CC chemokine receptor 4 (CCR4) axis in vitiligo and provide new possibilities for the clinical treatment of vitiligo.

Methods: A total of 30 patients with vitiligo from Affiliated Huaian No. Read More

View Article and Full-Text PDF

Vitiligo Health Education: A Study of Accuracy and Engagement of Online Educational Materials.

J Drugs Dermatol 2021 Jun;20(6):623-629

Introduction: Many vitiligo patients seek healthcare information online. However, the accuracy and quality of this information is unknown.

Objective: To determine the accuracy, quality, viewer engagement, and viewer experience of vitiligo videos on social media. Read More

View Article and Full-Text PDF

A Multi-Centered Case-Control Study of Vitiligo Support Groups and Quality of Life.

J Drugs Dermatol 2021 Jun;20(6):672-675

Background: There is limited research on the association between vitiligo support group membership and patient quality of life (QoL).

Objectives: To explore the association between support groups and QoL in those with vitiligo by evaluating and comparing the QoL of vitiligo support group members and non-support group members.

Methods: Support group members (n=135) and non-support group members (n=129) were recruited from the Global Vitiligo Foundation (GVF), and three academic medical centers respectively. Read More

View Article and Full-Text PDF

Impact of treatment delays on vitiligo during the COVID-19 pandemic: A retrospective study.

Dermatol Ther 2021 Jun 1:e15014. Epub 2021 Jun 1.

Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.

Due to the COVID-19 pandemic, routine treatments are delayed to some extent and their negative impacts have been widely reported. However, virtually nothing is known about vitiligo in the context of COVID-19. Therefore, we analyzed treatment delays and its impact on vitiligo, aiming to provide suggestions on vitiligo management within this special period. Read More

View Article and Full-Text PDF

Extracellular Vesicles as Potential Theranostic Platforms for Skin Diseases and Aging.

Pharmaceutics 2021 May 20;13(5). Epub 2021 May 20.

Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Korea.

Extracellular vesicles (EVs), naturally secreted by cells, act as mediators for communication between cells. They are transported to the recipient cells along with cargoes such as nucleic acids, proteins, and lipids that reflect the changes occurring within the parent cells. Thus, EVs have been recognized as potential theranostic agents for diagnosis, treatment, and prognosis. Read More

View Article and Full-Text PDF