7,145 results match your criteria Vitiligo


Effect of Combination NSAID and NBUVB treatment in Non-Photoadapters - A Pilot Study.

Photodermatol Photoimmunol Photomed 2019 Apr 20. Epub 2019 Apr 20.

Department of Dermatology, Henry Ford Hospital, Detroit, MI.

Background: Vitiligo is a disorder of dyspigmentation that can impact quality of life. While narrow band ultraviolet B (NBUVB) is an effective treatment for vitiligo, a sub-set of patients are unable to respond to phototherapy as they cannot photoadapt. However, nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to increase the minimal erythema dose. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/phpp.12476
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http://dx.doi.org/10.1111/phpp.12476DOI Listing
April 2019
1 Read

Oxidative stress-induced HMGB1 release from melanocytes: a paracrine mechanism underlying the cutaneous inflammation in vitiligo.

J Invest Dermatol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Xijing Hospital, Fourth Military Medical University, 127 Changle West Road, Xi'an, shaanxi, 710032, China. Electronic address:

Vitiligo is a cutaneous depigmentation disorder caused by the destruction of epidermal melanocytes. The generation and the skin infiltration of autoreactive CD8 cytotoxic T cells triggered by oxidative stress play a critical role in vitiligo. High-mobility group protein B1 (HMGB1) is a classic damage-associated molecular pattern (DAMP) molecule with strong proinflammatory effects in inflammatory reactions. Read More

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http://dx.doi.org/10.1016/j.jid.2019.03.1148DOI Listing

The efficacy and safety of targeted narrowband UVB therapy: a retrospective cohort study

Turk J Med Sci 2019 Apr 18;49(2):595-603. Epub 2019 Apr 18.

Background/aim: Phototherapy is a safe and effective treatment modality for numerous dermatological conditions. Recently, targeted phototherapy modalities have gained importance due to their advantages over conventional phototherapy.This retrospective study aimed to evaluate the safety and efficacy of targeted narrowband UVB phototherapy in patients with dermatological disorders

Materials And Methods: This single-center study included 173 patients who were treated with targeted narrowband UVB phototherapy. Read More

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http://online.journals.tubitak.gov.tr/openDoiPdf.htm?mKodu=s
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http://dx.doi.org/10.3906/sag-1810-110DOI Listing
April 2019
1 Read

Mucosal vitiligo in angles of the mouth: clinical and fluorescence aspects.

Rev Assoc Med Bras (1992) 2019 Mar 11;65(3):330-332. Epub 2019 Apr 11.

Research Center on Biological Chemistry (NQBio), Federal University of São João del-Rei (UFSJ), Divinópolis, MG, Brasil.

Vitiligo is the most common depigmenting, chronic acquired disease of the skin and mucosa. However, vitiligo of an unclassified type and mucosal subtype affecting only one area of the mucosa is considered quite uncommon. The diagnosis of vitiligo, regardless of its type, is clinical. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/1806-9282.65.3.330DOI Listing
March 2019
2 Reads

Vitiligo in a patient receiving infliximab for chronic plaque psoriasis.

Dermatol Ther 2019 Apr 17:e12917. Epub 2019 Apr 17.

Department of Dermatology, Shanghai Skin Disease Hospital, 1278 Baode Road, Shanghai 200443, China.

Infliximab is a TNF-a Inhibitor widely used in the treatment of moderate to severe chronic plaque psoriasis. Here, we report a case of vitiligo following infliximab administration in a patient with chronic plaque psoriasis. The case serves as a reminder of vitiligo induced by TNF-a-antagonist therapy. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/dth.12917
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http://dx.doi.org/10.1111/dth.12917DOI Listing
April 2019
3 Reads

[Analysis of epidemiological characteristics of drug induced liver injury associated with Baixianpi Preparations].

Zhongguo Zhong Yao Za Zhi 2019 Mar;44(5):1048-1052

Department of Pharmacy,Dongzhimen Hospital Afliated to Beijing University of Traditional Chinese Medicine Beijing 100700,China.

A retrospective study was performed in drug-induced liver injury(DILI) cases associated with Dictamni Cortex(Baixianpi,BXP) Preparations,which were treated at grade Ⅲ class A liver disease hospitals from 2008 to 2016 and spontaneously reported for adverse reactions between 2012 and 2016 at HILI Cloud(hilicloud.net). The results showed 25 DLII cases associated with BXP Preparations treated at grade Ⅲ class A liver disease hospitals during the 9 years,including only 14 cases in line with the clinical diagnostic criteria of Guidelines for the Diagnosis and Treatment of Herb-Induced Liver Injury. Read More

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http://www.cnki.net/kcms/doi/10.19540/j.cnki.cjcmm.20181217.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20181217.001DOI Listing
March 2019
2 Reads

Regulatory T-Cells in alopecia areata.

J Cutan Pathol 2019 Apr 16. Epub 2019 Apr 16.

Department of Pathology, Loyola University Medical Center, Maywood, IL.

Introduction: Alopecia areata (AA) is believed to have an autoimmune mechanism in which the hair follicles are targeted by CD4+ and CD8+ lymphocytes. Studies investigating the autoimmune mechanism of other cutaneous diseases, including vitiligo, demonstrated that Treg are a component of cutaneous immune privilege. Our study uses immunohistochemical staining in formalin-fixed, paraffin embedded tissue to examine the percentage of CD4+FoxP3+, CD25+FoxP3+ and CD8+FoxP3+ Treg in AA in human specimens. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cup.13479
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http://dx.doi.org/10.1111/cup.13479DOI Listing
April 2019
1 Read

Berberine protects immortalized line of human melanocytes from HO-induced oxidative stress via activation of Nrf2 and Mitf signaling pathway.

J Dermatol Sci 2019 Apr 2. Epub 2019 Apr 2.

Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China. Electronic address:

Background: Oxidative stress plays important roles in the pathogenesis of vitiligo. The removal of hydrogen peroxided (HO) has been established to be beneficial to vitiligo patients. Berberine (BBR), a natural isoquinoline alkaloid, has antioxidant activity, however, whether BBR can defend human melanocytes against oxidative injury remains to be elucidated. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2019.03.007DOI Listing

Sarcoid-like reaction and vitiligo occurring after nivolumab therapy in a patient with metastatic melanoma.

J Dermatol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan.

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http://dx.doi.org/10.1111/1346-8138.14887DOI Listing

Study on Assessment of Quality of Life and Depression in Patients of Vitiligo.

Indian Dermatol Online J 2019 Mar-Apr;10(2):153-157

Department of Community Medicice, Shree Krishna Hospital, Karamsad, Anand, Gujarat, India.

Context: Vitiligo is an autoimmune pigmentary disorder characterized by localized or generalized depigmentation of the skin. It is associated with significant stigma and has impact on patient's quality of life (QoL) and psychological wellbeing.

Aims: To see the variance in QoL and level of depression in vitiligo patients with extent of vitiligo. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_14_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434757PMC
April 2019
4 Reads

Association of Vitamin D Receptor Gene Polymorphisms and Serum 25-Hydroxy Vitamin D Levels in Vitiligo - A Case-control Study.

Indian Dermatol Online J 2019 Mar-Apr;10(2):131-138

Department of Preventive and Social Medicine, Government Medical College, Srinagar, Karan Nagar Srinagar, J and K, India.

Background: Vitamin D has stimulatory and protective effects on melanocytes and acts through its nuclear vitamin D receptor (VDR) on target cells. Various single-nucleotide polymorphisms (SNPs) in VDR genes have been described.

Aims: The aim was to study and compare the association of SNP of in VDR gene as well as the plasma vitamin D levels in vitiligo patients and healthy controls. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_97_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434755PMC
April 2019
3 Reads

Dietary Protein Deficit and Deregulated Autophagy: A New Clinico-diagnostic Perspective in Pathogenesis of Early Aging, Skin, and Hair Disorders.

Indian Dermatol Online J 2019 Mar-Apr;10(2):115-124

Department of Dermatology, Aesthetic Surgery and Intervention Dermatology, AURA Skin Institute, Chandigarh, India.

Background: Diet has an important role to play in the well-being of human body.

Aims: The study intends to establish the "hypothesis of conscious, selective, and self-destruction i.e. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_123_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434747PMC
April 2019
4 Reads

Systemic Redox Imbalance Along with Increased Serum Sialic Acid is Prevalent in Patients with Active Vitiligo: A Study from a Tertiary Care Teaching Hospital of Eastern India.

Indian J Dermatol 2019 Mar-Apr;64(2):97-100

Department of Laboratory Medicine, Calcutta School of Tropical Medicine, Government of West Bengal, Kolkata, West Bengal, India.

Background: Vitiligo is one of the common depigmenting disorders causing disfigurement and affecting the quality of life. Redox imbalance is known to play a contributory role in melanocyte destruction. Serum sialic acid (SA) is an important marker of the acute-phase response and is associated with oxidative protein damage. Read More

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http://dx.doi.org/10.4103/ijd.IJD_448_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440190PMC

Assessment of Melanogenesis in a Pigmented Human Tissue-Cultured Skin Equivalent.

Indian J Dermatol 2019 Mar-Apr;64(2):85-89

Department of Dermatology, Venereology, and Allergology, Goethe University Hospital, Frankfurt/Main, Germany.

Background: Organotypic tissue-cultured skin equivalents are used for a broad range of applications either as possible substitute for animal tests or for transplantation in patient-centered care.

Aims: In this study, we implemented melanocytes in a tissue-cultured full-thickness skin equivalent, consisting of epidermis and dermis. The versatility of this skin-like model with respect to pigmentation and morphological criteria was tested. Read More

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http://www.e-ijd.org/text.asp?2019/64/2/85/254158
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http://dx.doi.org/10.4103/ijd.IJD_410_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440179PMC
April 2019
5 Reads

The nail flag sign in heart transplant recipients: case reports and review of the patients with the flag sign of the nail.

Authors:
Philip R Cohen

Dermatol Online J 2019 Mar 15;25(3). Epub 2019 Mar 15.

San Diego Family Dermatology, National City, California.

The nail plate flag sign is a distinctive nail plate change that appears as white, red, white, and red sequential transverse bands beginning at the proximal nail fold. This distinctive nail change was initially described in patients with diabetes mellitus and leprosy; indeed, it was considered to be characteristic, but not diagnostic of leprosy. Subsequently, the flag sign was observed in patients with vitiligo. Read More

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March 2019
1 Read

Adherence to a novel home phototherapy system with integrated features.

Dermatol Online J 2019 Mar 15;25(3). Epub 2019 Mar 15.

Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Objective: To measure adherence using a novel home UVB phototherapy system designed to promote adherence.

Study Design: A retrospective, observational study conducted to evaluate patients' adherence to a prescribed three-times-per-week treatment protocol using a novel home phototherapy system with integrated features designed to improve adherence.

Methods: Data was collected from 18 psoriasis patients, 27 vitiligo patients, and three atopic dermatitis patients using a novel home phototherapy system under normal use conditions. Read More

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March 2019
1 Read

Apremilast is effective in controlling the progression of adult vitiligo: a case series.

Dermatol Ther 2019 Apr 12:e12923. Epub 2019 Apr 12.

CUTIS Institute of Dermatology, Srinagar, Kashmir, India.

There are limited treatment options available to control the progression of vitiligo and most of these treatment options carry the risk of both short term as well as long-term adverse effects. Apremilast has emerged as a promising treatment option in psoriasis and many other cutaneous disorders. We report herein the successful use of oral apremilast therapy in controlling the progression of adult onset vitiligo in 13 patients. Read More

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http://dx.doi.org/10.1111/dth.12923DOI Listing

Acute liver failure associated with Fructus Psoraleae: a case report and literature review.

BMC Complement Altern Med 2019 Apr 11;19(1):84. Epub 2019 Apr 11.

Department of Dermatology, Qianfoshan Hospital, Shandong University, 16766 Jing-Shi Road, Jinan, 250014, China.

Background: Fructus Psoraleae is the seed of Psoralea corylifolia Linn. Fructus Psoraleae has been shown to be effective in treating some skin diseases, such as vitiligo. As a main ingredient in five types of herbs in the Qubaibabuqi tablet formula, Fructus Psoraleae plays an important role in the treatment of vitiligo. Read More

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https://bmccomplementalternmed.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12906-019-2493-9DOI Listing
April 2019
2 Reads

New insights into leukotrichia in nonsegmental vitiligo: A cross-sectional study.

Indian J Dermatol Venereol Leprol 2019 Apr 10. Epub 2019 Apr 10.

Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Background: Leukotrichia has been considered a predictor of poor outcome in vitiligo. However, studies considering the different clinical aspects of leukotrichia in vitiligo patients are few.

Aim: Our aim was to conduct a detailed clinical study to provide insights into the relevance and associations of leukotrichia in non-segmental vitiligo. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_49_18DOI Listing

Therapeutic Potential of Patient iPSC-Derived iMelanocytes in Autologous Transplantation.

Cell Rep 2019 Apr;27(2):455-466.e5

Institute of Regenerative Medicine, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu 212001, China; Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan; School of Medicine, Yokohama City University, Yokohama 236-0004, Japan. Electronic address:

Induced pluripotent stem cells (iPSCs) are a promising melanocyte source as they propagate indefinitely and can be established from patients. However, the in vivo functions of human iPSC-derived melanocytes (hiMels) remain unknown. Here, we generated hiMels from vitiligo patients using a three-dimensional system with enhanced differentiation efficiency, which showed characteristics of human epidermal melanocytes with high sequence similarity and involved in multiple vitiligo-associated signaling pathways. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.046DOI Listing
April 2019
6 Reads

Janus kinase inhibitor tofacitinib does not facilitate the repigmentation in mouse model of rhododendrol-induced vitiligo.

J Dermatol 2019 Apr 10. Epub 2019 Apr 10.

Department of Dermatology, Yamagata University School of Medicine, Yamagata, Japan.

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http://dx.doi.org/10.1111/1346-8138.14879DOI Listing
April 2019
1 Read

Secondary metabolites produced by endophytic Pantoea ananatis derived from roots of Baccharoides anthelmintica and their effect on melanin synthesis in murine B16 cells.

Nat Prod Res 2019 Apr 10:1-6. Epub 2019 Apr 10.

a Key Laboratory of Plant Resources and Chemistry in Arid Regions , Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Urumqi , Xinjiang , PR China.

Five indole derivatives, 1H-indol-7-ol (1), tryptophol (2), 3-indolepropionic acid (3), tryptophan (4), 3,3-di(1H-indol-3-yl)propane-1,2-diol (5) and two diketopiperazines, cyclo(L-Pro-L-Tyr) (6), cyclo[L-(4-hydroxyprolinyl)-L-leucine (7) along with one dihydrocinnamic acid (8) were isolated from Pantoea ananatis VERA8, that endophytic bacteria derived from Baccharoides anthelmintica roots. This is a first report towards an isolation of endophytic strains (funji or bacteria) from the B. anthelmintica herb. Read More

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http://dx.doi.org/10.1080/14786419.2019.1597354DOI Listing
April 2019
0.919 Impact Factor

Study on the Use of Microbial Cellulose as a Biocarrier for 1,3-Dihydroxy-2-Propanone and Its Potential Application in Industry.

Polymers (Basel) 2018 Apr 14;10(4). Epub 2018 Apr 14.

Faculty of Horticulture, Biotechnology and Landscape Architecture, Warsaw University of Life Sciences-SGGW, Nowoursynowska St. 166, 02-787 Warsaw, Poland.

Can microbial cellulose (MC) be used as a bio-carrier for 1,3-dihydroxy-2-propanone (DHA)? The aim of this study was to examine the possibility of using MC as a biomaterial for DHA transferring into the stratum corneum and inducing changes in skin color. The MC patches were obtained from strain and incubated in solutions with various concentrations of DHA (g·L: 20; 50; 80; 110) at 22 °C for 24 h. Afterwards; the patches were applied onto the skin for 15, 30, or 60 min. Read More

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http://dx.doi.org/10.3390/polym10040438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415240PMC

Jaundice and anaemia as presenting features of an incomplete autoimmune polyglandular syndrome type II.

BMJ Case Rep 2019 Apr 8;12(4). Epub 2019 Apr 8.

Department of General Medicine, R.G. Kar Medical College and Hospital, Kolkata, India.

The coexistence of adrenal failure with either autoimmune thyroid disease and/or type 1 diabetes is defined as autoimmune polyglandular syndrome (APS) type 2 or Schmidt's syndrome. Vitiligo, hypergonadotropic hypogonadism, chronic autoimmune hepatitis, alopecia, pernicious anaemia and seronegative arthritis may also be present. We present a case of 45-year-old Indian man with progressive jaundice and asthenia for 3 months. Read More

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http://dx.doi.org/10.1136/bcr-2018-228490DOI Listing
April 2019
1 Read

Vitiligoid hypopigmentation associated with pembrolizumab in metastatic head and neck cancer.

Authors:
Ajaz Bulbul

Oxf Med Case Reports 2019 Mar 29;2019(3):omz016. Epub 2019 Mar 29.

Division of Internal Medicine, Department of Hematology/Oncology, Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX, USA.

Cutaneous adverse events are common with the use of immunotherapy. Although only 5% of patients develop severe reactions, about half will develop mild to moderate cutaneous adverse events. Vitiligo has been seen in melanomas treated with checkpoint inhibitors (CPI). Read More

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http://dx.doi.org/10.1093/omcr/omz016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440267PMC
March 2019
2 Reads

Validation of a Physicians Global Assessment (PGA) tool for vitiligo extent: results of an international vitiligo expert meeting.

Pigment Cell Melanoma Res 2019 Apr 3. Epub 2019 Apr 3.

Department of Dermatology, Ghent University Hospital, Ghent, Belgium.

Currently, vitiligo lacks a validated Physician Global Assessment (PGA) for disease extent. This PGA can be used to stratify and interpret the numeric scores obtained by the Vitiligo Extent Score (VES). We investigated the interrater reliability of a 5-point PGA scale during an international vitiligo workshop. Read More

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http://dx.doi.org/10.1111/pcmr.12784DOI Listing
April 2019
2 Reads
4.619 Impact Factor

Panniculitis and vitiligo occurring during BRAF and MEK inhibitors combination in advanced melanoma patients: Potential predictive role of treatment efficacy.

PLoS One 2019 2;14(4):e0214884. Epub 2019 Apr 2.

Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, Medical Oncology, University of Brescia at ASST-Spedali Civili, Brescia, Italy.

Panniculitis and vitiligo-like lesions have been recently identified as rare cutaneous side effects of the combination of BRAF and MEK inhibitors, a standard of care in metastatic and locally advanced BRAF V600 mutated melanoma. An immune-mediated mechanism has been advocated in the pathogenesis of these skin lesions. Herein we retrospectively reviewed our institutional experience with the aim to explore the association between the occurrence of panniculitis and vitiligo-like lesions during combination therapy with dabrafenib (D) and trametinib (T) and outcome of advanced melanoma patients. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214884PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445428PMC
April 2019
1 Read

Can we consider silymarin as a treatment option for vitiligo? A double-blind controlled randomized clinical trial of phototherapy plus oral Silybum marianum product versus phototherapy alone.

J Dermatolog Treat 2019 Apr 2:1-5. Epub 2019 Apr 2.

a Molecular Dermatology Research Center, Shiraz University of Medical Sciences , Shiraz , Iran.

Introduction: Vitiligo is a chronic skin disorder caused by destruction of the skin melanocytes, which presents as a depigmented area in the skin. This study examined the effect of Phototherapy plus oral Silybummarianum on the treatment of skin lesions of Vitiligo.

Materials And Methods: In this randomized controlled clinical trial, 34 patients with vitiligo who were referred to Dermatology Clinic of Shahid Faghihi Hospital, Shiraz, Iran, were randomly divided into two groups. Read More

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http://dx.doi.org/10.1080/09546634.2019.1595506DOI Listing
April 2019
3 Reads

Natural product-based design, synthesis and biological evaluation of 2',3,4,4'-tetrahydrochalcone analogues as antivitiligo agents.

Bioorg Chem 2019 Mar 23;87:523-533. Epub 2019 Mar 23.

State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China. Electronic address:

A bioactive component, 2',3,4,4'-tetrahydrochalcone (RY3-a) was first isolated from Vernohia anthelmintica (L.) willd seeds, and a set of its analogs, RY3-a-1-RY3-a-15 and RY3-c were designed and synthesized. Biological activity assays showed that RY3-c exhibited better melanogenesis and antioxidant activity and lower toxicity in comparison with RY3-a and butin. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.03.054DOI Listing

Dermatitis herpetiformis arising within vitiligo in a patient with autoimmune polyendocrine syndrome type 3.

Int J Dermatol 2019 Mar 28. Epub 2019 Mar 28.

Department of Dermatology, Allergology and Venereology, Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1111/ijd.14446DOI Listing

Evaluation of genotyping methods and costs for MTHFR, CBS and MTRR polymorphisms in patients with vitiligo.

Eur Rev Med Pharmacol Sci 2019 Mar;23(5):1841-1844

Pathology Unit, Santa Maria della Pietà Hospital, Nola (ASL NA 3 SUD), Naples, Italy.

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http://dx.doi.org/10.26355/eurrev_201903_17217DOI Listing

Melanocyte Chitosan/Gelatin Composite Fabrication with Human Outer Root Sheath-Derived Cells to Produce Pigment.

Sci Rep 2019 Mar 26;9(1):5198. Epub 2019 Mar 26.

Department of Plastic and Reconstructive Surgery, the Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.

The hair follicle serves as a melanocyte reservoir for both hair and skin pigmentation. Melanocyte stem cells (MelSCs) and melanocyte progenitors reside in the bulge/sub-bulge region of the lower permanent portion of the hair follicle and play a vital role for repigmentation in vitiligo. It would be beneficial to isolate MelSCs in order to further study their function in pigmentary disorders; however, due to the lack of specific molecular surface markers, this has not yet been successfully accomplished in human hair follicles (HuHF). Read More

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http://dx.doi.org/10.1038/s41598-019-41611-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435804PMC
March 2019
1 Read

The impact of therapeutic modalities on patients with atopic dermatitis, psoriasis and vitiligo treated with phototherapy in the Jagiellonian University Outpatient Clinic.

Pol Merkur Lekarski 2019 Mar;46(273):125-129

Department of Dermatology, Collegium Medicum, Jagiellonian University in Cracow, Poland.

Phototherapy involves repeated exposure of the skin to ultraviolet light and is commonly used in various dermatological diseases such as: psoriasis, atopic dermatitis and vitiligo. It constitutes a highly preferable treatment modality due to acceptable benefit/risk ratio.

Aim: The aim of the study is to characterize parameters such as: number of PUVA or NB-UVB sessions, cumulative doses of phototherapy, values of minimal erythema doses (MED), periods of the year during phototherapy sessions in patients with vitiligo, atopic dermatitis and psoriasis attending the Jagiellonian University Outpatient Clinic. Read More

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Childhood Vitiligo.

Am J Clin Dermatol 2019 Mar 25. Epub 2019 Mar 25.

First Department of Dermatology and Venereology, National and Kapodistrian University of Athens School of Medicine, "A. Sygros" Hospital for Skin and Venereal Diseases, Athens, Greece.

Vitiligo is a common acquired depigmenting skin disease characterized by a progressive loss of functional melanocytes. It may appear from the first years of life to late adulthood. Childhood vitiligo (CV), defined as vitiligo that begins before the age of 12 years, is common and may differ from post-CV in terms of epidemiology, clinical presentation, comorbidities, and treatment options. Read More

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http://dx.doi.org/10.1007/s40257-019-00430-0DOI Listing
March 2019
1 Read

Patient satisfaction and physician productivity in shared medical appointments for vitiligo.

J Am Acad Dermatol 2019 Mar 22. Epub 2019 Mar 22.

Department of Dermatology, University of Massachusetts Medical School, 364 Plantation St., LRB 225, Worcester, MA, 01605, USA. Electronic address:

Background: The Shared Medical Appointment (SMA) allows patients with a similar diagnosis to be simultaneously cared for and educated by one provider, which has had success in dermatology and other fields of specialty. The SMA provides a potential solution to improve patient access to dermatologists.

Objective: The purpose of this study was to implement SMA for vitiligo patients and compare it to traditional appointments with regard to patient satisfaction, time to appointment, number of new patients seen per month, and generated revenue. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.03.044DOI Listing

Disorders of Hypopigmentation

J Drugs Dermatol 2019 Mar;18(3):s115-s116

Hypopigmentation and depigmentation of the skin can be due to multiple causes and has a broad differential diagnosis. The most common cause of depigmentation worldwide is vitiligo. This disorder affects 1-2% of the world’s population and is seen in all races. Read More

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March 2019
1 Read

The Use of Janus Kinase Inhibitors in Vitiligo: A Review of the Literature.

J Cutan Med Surg 2019 Mar 22:1203475419833609. Epub 2019 Mar 22.

1 Queen's University, Kingston, ON, Canada.

Vitiligo is a common acquired depigmenting disorder characterized by the development of white macules and patches due to the loss of melanocytes. Patients with vitiligo can be stigmatized by society, making the disease a source of psychological stress that can considerably affect quality of life. The goal of vitiligo treatment is to obtain skin repigmentation in the majority of cases, and less commonly to depigment the remaining normal skin. Read More

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http://journals.sagepub.com/doi/10.1177/1203475419833609
Publisher Site
http://dx.doi.org/10.1177/1203475419833609DOI Listing
March 2019
4 Reads

Multiple Autoimmune Disorders in Aicardi-Goutières Syndrome.

Pediatr Neurol 2019 Feb 2. Epub 2019 Feb 2.

Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

Background: Aicardi-Goutières syndrome is an early-onset encephalopathy with presumed immune pathogenesis caused by inherited defects in nucleic acid metabolism. It is a model disease to study systemic autoimmunity, and there are many clinical, genetic, and basic science considerations that underline a possible overlap between Aicardi-Goutières syndrome and systemic lupus erythematosus.

Results: We describe a 15-year-old girl with Aicardi-Goutières syndrome due to compound heterozygous pathogenic variants in SAMHD1 (sterile alpha motif domain and HD domain-containing protein 1). Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2019.01.017DOI Listing
February 2019
2 Reads

[H Factor Deficiency: A Case with an Atypical Presentation].

Acta Med Port 2019 Feb 28;32(2):158-161. Epub 2019 Feb 28.

Unidade de Imunodeficiências Primárias. Serviço de Pediatria. Hospital Dona Estefânia. Centro Hospitalar Lisboa Central. Lisboa. Chronic Diseases Research Center. NOVA Medical School. Lisboa. Portugal.

We report a case of an 18-month-old boy with H factor deficiency with atypical presentation: recurrent acute otitis media and several maternal family members with autoimmune disorders (vitiligo, thyroiditis and immune trombocytopenia). Blood tests revealed low C3 and AH50, as well as low properdin and H factor. I factor was normal. Read More

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https://www.actamedicaportuguesa.com/revista/index.php/amp/a
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http://dx.doi.org/10.20344/amp.10301DOI Listing
February 2019
5 Reads

Frontal fibrosing alopecia demographics: a survey of 29 patients.

Cutis 2018 Feb;102(2):E16-E22

Division of Dermatology, Washington University, USA.

Frontal fibrosing alopecia (FFA) is a form of scarring alopecia whose diagnosis is increasing globally. Although its etiology is unknown, FFA is thought to be a clinical subset of lichen planopilaris (LPP) that primarily affects postmenopausal women. Patients diagnosed with FFA between January 2006 and December 2013 at clinics of the Washington University Division of Dermatology (St. Read More

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February 2018
10 Reads

Induction of Pigmentation Through Microneedling in Stable Localized Vitiligo Patients.

Dermatol Surg 2019 Mar 15. Epub 2019 Mar 15.

Santa Casa de Misericórdia Recife, Pernambuco, Brazil Departamento de Dermatologia e Radioterapia FMB-Unesp Botucatu, São Paulo, Brazil.

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http://dx.doi.org/10.1097/DSS.0000000000001846DOI Listing
March 2019
3 Reads

Clinical and epidemiological profile of patients attended in a vulvar clinic of the dermatology outpatient unit of a tertiary hospital during a 4-year period.

Int J Dermatol 2019 Mar 20. Epub 2019 Mar 20.

Department of Dermatology, Hospital das Clínicas of the University of São Paulo Medical School, São Paulo, Brazil.

Background: Vulvar complaints are among the most frequent causes for a woman to visit a healthcare provider. The diseases of this area of the body may be a challenge to diagnose. In this study, we assess epidemiologic and clinical data of patients in an outpatient vulvar clinic in the dermatology department of a tertiary hospital. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ijd.14442
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http://dx.doi.org/10.1111/ijd.14442DOI Listing
March 2019
4 Reads

CDH1 and DDR1 common variants confer risk to vitiligo and autoimmune comorbidities.

Gene 2019 Jun 16;700:17-22. Epub 2019 Mar 16.

Vitiligo and Melasma Research Association, Bordeaux, France.

The weaker expression of the two main proteins adhering melanocytes to the epidermis basal layer, Epithelial Cadherin (E-cadherin) and Discoidin Domain Receptor Tyrosine kinase 1 (DDR1), has been implicated as one of the aggravating factors in the loss of melanocytes in vitiligo. The present study was designed to assess the association between single nucleotide polymorphisms (SNP) in the genes encoding these proteins, CDH1 and DDR1, and the risk of developing vitiligo. The independent case-control study was conducted on the sample including152 patients with vitiligo and 152 matched controls. Read More

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http://dx.doi.org/10.1016/j.gene.2019.03.026DOI Listing

A randomized comparative study of the effect of betamethasone oral mini-pulse therapy versus oral azathioprine in progressive non-segmental vitiligo.

J Am Acad Dermatol 2019 Mar 16. Epub 2019 Mar 16.

Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi.

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http://dx.doi.org/10.1016/j.jaad.2019.03.025DOI Listing

Overview of Medical Therapies and Phototherapy in Vitiligo Based on Their Pathogenetic Action and the Role of Platelet-Rich Plasma.

J Cutan Aesthet Surg 2018 Oct-Dec;11(4):167-168

Department of Dermatology, Dr. Ram Manohar Lohia Hospital and Post Graduate Institute of Medical Education and Research, New Delhi, India.

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http://dx.doi.org/10.4103/JCAS.JCAS_68_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371727PMC

Palmoplantar vitiligo: an overlooked entity.

J Eur Acad Dermatol Venereol 2019 Mar 18. Epub 2019 Mar 18.

San Gallicano Dermatological Institute, via Elio Chianesi 53, Rome, 00144, Italy.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.15578
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http://dx.doi.org/10.1111/jdv.15578DOI Listing
March 2019
5 Reads

Nano-erythrocyte membrane-chaperoned 5-fluorouracil liposomes as biomimetic delivery platforms to target hepatocellular carcinoma cell lines.

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):989-996

a Kayyali Chair for Pharmaceutical Industry, Department of Pharmaceutics, College of Pharmacy , King Saud University , Riyadh , Saudi Arabia.

Nano-erythrocyte coating has been developed as an interesting biomimetic platform to provide hybrid nano-carriers with innate functions to target liver cancer. This goal was achieved by coating nano-erythrocyte membranes (NEMs) onto 5-fluorouracil (5-FU)-loaded liposomes (LPs) to produce NEM-5-FU-LPs. This framework is used to promote the escape of 5-FU-LPs from degradation during systemic circulation. Read More

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http://dx.doi.org/10.1080/21691401.2019.1577887DOI Listing
December 2019
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Association of PTPN22 1858C/T Polymorphism with Autoimmune Diseases: A Systematic Review and Bayesian Approach.

J Clin Med 2019 Mar 12;8(3). Epub 2019 Mar 12.

Department of Pediatrics, Yonsei University College of Medicine, Yonsei-ro 50, Seodaemun-gu, C.P.O. Box 8044, Seoul 03722, Korea.

The 1858T allele in the protein tyrosine phosphatase non-receptor type 22 (PTPN22) locus shows one of the strongest and most consistent genetic associations with autoimmune diseases. We synthesized all meta-analyses reporting a genetic association of the PTPN22 1858T C/T polymorphism with autoimmune diseases. This work examined their validity to discover false positive results under Bayesian methods. Read More

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https://www.mdpi.com/2077-0383/8/3/347
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http://dx.doi.org/10.3390/jcm8030347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462981PMC
March 2019
7 Reads

A Nationwide, Population-based Cohort Study on Potential Autoimmune Association of Ménière Disease to Atopy and Vitiligo.

Sci Rep 2019 Mar 13;9(1):4406. Epub 2019 Mar 13.

Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Konyang University, Daejeon, Republic of Korea.

Ménière disease (MD), an idiopathic disorder of sensorineural hearing loss and vertigo, shares many similarities with two common skin conditions, atopic dermatitis (AD) and vitiligo. Recent studies have suggested that MD may be related to or triggered by autoimmune conditions, notably Hashimoto thyroiditis and alopecia areata. These evidences led to the authors contemplating the possibility of immunological bridge between MD and the two skin conditions. Read More

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http://dx.doi.org/10.1038/s41598-019-40658-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416401PMC
March 2019
1 Read