7,703 results match your criteria Vitiligo


An analysis of patient satisfaction in a pigmentary disorders clinic from a quaternary referral service.

Australas J Dermatol 2020 Jul 7. Epub 2020 Jul 7.

The Skin Hospital, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1111/ajd.13397DOI Listing

Selenium Level in Patients with Vitiligo: A Meta-Analysis.

Biomed Res Int 2020 11;2020:7580939. Epub 2020 Jun 11.

Department of Dermatology and Venereology, The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China.

Background: It has been reported that deficiency of selenium can cause autoimmune disease. This meta-analysis was aimed at evaluating whether there exits an association between selenium level and vitiligo.

Methods: A comprehensive search was conducted on PubMed, Embase, China National Knowledge Infrastructure (CNKI), Wanfang Med Online, and China VIP databases from the inception to February 12, 2019. Read More

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http://dx.doi.org/10.1155/2020/7580939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306096PMC

Irritant contact dermatitis, multiple pyogenic granulomas and vitiligo following topical application of tretinoin.

Dermatol Ther 2020 Jul 4:e13966. Epub 2020 Jul 4.

Department of Dermatology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

A 65-year-old women presented with sharply demarcated macules and small nodules on her face and neck for 2.5 years. They first appeared on her left face and gradually spread to her whole face and neck. Read More

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http://dx.doi.org/10.1111/dth.13966DOI Listing

Decreased levels of interleukin 27 in the serum of vitiligo patients.

An Bras Dermatol 2020 Jun 16. Epub 2020 Jun 16.

Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Background: Vitiligo is a common skin disorder in which melanocytes are destroyed by auto-reactive immune responses. The loss of melanocytes results in the appearance of depigmented areas in different parts of the body. Cytokines have remarkable roles in the pathogenesis of vitiligo, such as IL-1, IL-6, and TNF-α; interleukin 27 (IL-27) is a new member of the IL-6/IL-12 family, mainly released by activated antigen-presenting cells. Read More

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http://dx.doi.org/10.1016/j.abd.2020.02.005DOI Listing

Is vitiligo associated with wearing plastic shoes in a podoconiosis endemic region of Ethiopia?

J Infect Dev Ctries 2020 Jun 29;14(6.1):22S-27S. Epub 2020 Jun 29.

UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR), World Health Organization, Geneva, Switzerland.

Introduction: Endemic non-filarial elephantiasis also known as podoconiosis often affects bare footed farmers and is endemic in Ethiopia. The disease is prevented by wearing shoes. We recently observed several patients presenting to a dermatology clinic with skin depigmentation after wearing plastic shoes ("shoe-contact vitiligo") which may deter shoe-wearing. Read More

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http://dx.doi.org/10.3855/jidc.11705DOI Listing

Association of myalgias with compounded topical Janus kinase inhibitor use in vitiligo.

JAAD Case Rep 2020 Jul 16;6(7):637-639. Epub 2020 May 16.

Multicultural Dermatology Center, Department of Dermatology, Henry Ford Health System, Detroit, Michigan.

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http://dx.doi.org/10.1016/j.jdcr.2020.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317685PMC

Validation of the diagnostic criteria for segmental vitiligo.

Indian J Dermatol Venereol Leprol 2020 Jul 1. Epub 2020 Jul 1.

Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India.

Background: Segmental vitiligo has a different clinical course and prognosis as compared to nonsegmental vitiligo, which necessitates its correct diagnosis. It may be difficult to distinguish segmental vitiligo from the limited or focal types of nonsegmental vitiligo.

Objective: To validate the previously proposed diagnostic criteria for segmental vitiligo. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_704_18DOI Listing

A case of new-onset vitiligo in a patient on tofacitinib and brief review of paradoxical presentations with other novel targeted therapies.

Dermatol Online J 2020 Mar 15;26(3). Epub 2020 Mar 15.

Department of Dermatology, Division of Internal Medicine, University of Texas MD Anderson Cancer Center, Houston, TX Department of Dermatology, University of Texas Health Science Center at Houston, Houston, TX.

With recent advancements in the understanding of vitiligo pathogenesis, Janus kinase (JAK) inhibitors have emerged as a promising new treatment modality, but their effects remain incompletely elucidated. Tofacitinib, an oral JAK 1/3 inhibitor approved for the treatment of rheumatoid arthritis, has previously been shown to induce significant re-pigmentation in vitiligo. However, as with other novel targeted therapies, cutaneous adverse effects have been observed. Read More

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Comparison of responses of melanocyte lineages from p75(+) and p75(-) human scalp-derived neural crest stem cells under phototherapy.

Lasers Med Sci 2020 Jun 30. Epub 2020 Jun 30.

Department of Dermatology, Renji Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, 200127, China.

Phototherapy is an effective therapeutic option in the treatment of vitiligo; however, responses varied among the different types. The underlying mechanism has scarcely been investigated. To investigate and compare the effects of phototherapy on the mutation of melanocyte lineage differentiated from human scalp-derived neural crest stem cells (HS-NCSCs) with p75 neurotrophin receptor expression positive and p75 neurotrophin receptor expression negative group in vitro, the HS-NCSCs were isolated from fetal scalp tissue, which is identified by immunofluorescent staining. Read More

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http://dx.doi.org/10.1007/s10103-020-03047-6DOI Listing

Vitiligo and Rise in Blood Pressure - a Case-Control Study in a Referral Dermatology Clinic in Southern Iran.

Clin Cosmet Investig Dermatol 2020 22;13:425-430. Epub 2020 Jun 22.

Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: Vitiligo is an acquired hypopigmentation condition in which well-defined macules can develop virtually everywhere on the patients' skin. This analytic case-control study was conducted in Faghihi Hospital outpatient dermatology clinic, affiliated to Shiraz University of Medical Sciences, southern Iran from June to September 2019. Furthermore, we studied the relationship of hypertension with activity, age of onset, duration, affected body surface area and type of vitiligo. Read More

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http://dx.doi.org/10.2147/CCID.S257022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319509PMC

Meeting Report: 68 Montagna Symposium on the Biology of Skin: "Decoding Complex Skin Diseases: Integrating Genetics, Genomics, and Disease Biology".

J Invest Dermatol 2020 Jun 27. Epub 2020 Jun 27.

Department of Dermatology, University of Michigan, Ann Arbor, MI; Ann Arbor Veterans Affairs Hospital, Ann Arbor, MI.

The 68 Montagna Symposium on the Biology of the Skin was held from October 10-14, 2019, at Salishan Lodge in Gleneden Beach, Oregon. The theme of the meeting was "Decoding Complex Skin Diseases: Integrating Genetics, Genomics, and Disease Biology". The meeting emphasized integration of multiple themes and disciplines to better understand some of the most common skin diseases, ranging from psoriasis to alopecia areata to vitiligo to lupus erythematosus to atopic dermatitis and food allergy. Read More

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http://dx.doi.org/10.1016/j.jid.2020.06.010DOI Listing

Follicular unit extraction of leukotrichia and replacement with follicular units from scalp in combination with epidermal cell suspension in a case of vitiligo.

Dermatol Ther 2020 Jun 28:e13916. Epub 2020 Jun 28.

Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.1111/dth.13916DOI Listing

Serum level of antioxidant vitamins and minerals in patients with vitiligo, a systematic review and meta-analysis.

J Trace Elem Med Biol 2020 Jun 5;62:126570. Epub 2020 Jun 5.

Department of Dermatology and Venereal Diseases, Dezhou People's Hospital, Dezhou, China. Electronic address:

Background: Antioxidant status is considered as important factor in the pathogenesis of vitiligo. However, there are controversial findings about serum status of antioxidants in vitiligo patients. The purpose of this study was to systematically review the evidences comparing the serum levels of antioxidant vitamins and minerals between vitiligo patients and controls, and performing meta-analysis of the results. Read More

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http://dx.doi.org/10.1016/j.jtemb.2020.126570DOI Listing

H O -induced oxidative stress disrupts mitochondrial functions and impairs migratory potential of human epidermal melanocytes.

Exp Dermatol 2020 Jun 24. Epub 2020 Jun 24.

Department of Dermatology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210009, China.

Reactive oxygen species (ROS) have already been demonstrated to impede the migratory ability in non-melanocytic cell lines by depleting mitochondrial ATP production. Therefore, understanding the mitochondrial metabolic response to migration in the presence of ROS should be a key to understanding repigmentation in vitiligo. This study aimed to investigate the energy mechanism associated with the ROS-mediated attenuation of melanocyte migration. Read More

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http://dx.doi.org/10.1111/exd.14134DOI Listing

Alemtuzumab-induced halo nevus-like hypopigmentation -: New insights into secondary skin autoimmunity in response to an immune cell-depleting antibody.

J Eur Acad Dermatol Venereol 2020 Jun 24. Epub 2020 Jun 24.

Clinic of Neurology with Institute for Translational Neurology, University of Münster, Münster, Germany.

We describe a 33-year-old male patient who developed hypopigmentation around his melanocytic nevi with disappearance of the nevi in August 2018. In June 2016 he had been diagnosed with highly active RRMS and treated with alemtuzumab in September 2016 for the first time. In September 2017 another cycle of alemtuzumab was administered. Read More

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http://dx.doi.org/10.1111/jdv.16781DOI Listing

The Effect of Isotretinoin on Vitiligo and Autoimmune Comorbidity.

J Drugs Dermatol 2020 Jun;19(6):637-638

Several case reports have noted development of vitiligo as a potential side-effect of isotretinoin. In an IRB approved on-line survey of vitiligo patients we queried 1,301 vitiligo patients, 1115 with generalized vitiligo responding as to whether they had taken isotretinoin to address whether this issue was a common phenomenon amongst vitiligo patients. 3. Read More

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http://dx.doi.org/10.36849/JDD.2020.10.36849/JDD.2020.4938DOI Listing

The efficacy of fractional carbon dioxide laser combined with narrow-band ultraviolet B phototherapy for non-segmental vitiligo: a systematic review and meta-analysis.

Lasers Med Sci 2020 Jun 23. Epub 2020 Jun 23.

Department of Dermatology, Soonchunhyang University Hospital, 59 Daesahwan-ro, Yongsan-gu, Seoul, 04401, South Korea.

Fractional carbon dioxide (CO) laser has been used with conventional treatments for vitiligo, demonstrating more effectiveness compared with conventional treatments alone. Especially, fractional CO laser combined with narrow-band ultraviolet B (NB-UVB) was shown to induce more improvement compared with NB-UVB monotherapy for treating stable non-segmental vitiligo. However, the effectiveness of fractional CO laser plus NB-UVB for the treatment of non-segmental vitiligo remains controversial. Read More

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http://dx.doi.org/10.1007/s10103-020-03069-0DOI Listing

Is Gene Polymorphism Associated with Vitiligo?

Indian J Dermatol 2020 May-Jun;65(3):173-177

College of Pharmacy, PGIMS, Pt. B.D. Sharma University of Health Sciences, Rohtak, Haryana, India.

Background: -acetyltransferase-2 (NAT2) is a phase II xenobiotic enzyme that plays an important role against oxidative stress-mediated reactive oxygen species protection. Polymorphism in specific genotypes of NAT2 may lead to increase an imbalance in antioxidant systems and may influence the pathogenesis of vitiligo. We conducted this study to see the association between gene polymorphism and risk of vitiligo. Read More

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http://dx.doi.org/10.4103/ijd.IJD_388_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292445PMC

Genome-wide association study identifies CDH13 as a susceptibility gene for rhododendrol-induced leukoderma.

Pigment Cell Melanoma Res 2020 Jun 18. Epub 2020 Jun 18.

Department of Dermatology, Faculty of Medicine, Yamagata University, Yamagata, Japan.

Racemic RS-4-(4-hydroxyphenyl)-2-butanol (rhododendrol; trade name: Rhododenol [RD]), which is used in topical skin-lightening cosmetics, was unexpectedly reported in Japan to induce leukoderma or vitiligo called RD-induced leukoderma (RIL) after repeated application. To our knowledge, no studies have investigated chemical-induced vitiligo pathogenesis on a genome-wide scale. Here, we conducted a genome-wide association study (GWAS) for 147 cases and 112 controls. Read More

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http://dx.doi.org/10.1111/pcmr.12904DOI Listing

Expression of immune checkpoints in active nonsegmental vitiligo: a pilot study.

Int J Dermatol 2020 Jun 18. Epub 2020 Jun 18.

Pathology and Laboratory Medicine, London Health Sciences Centre, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.

Background: Vitiligo is a depigmentary skin disfigurement resulting from destruction of melanocytes caused by a possible malfunctioning immunity. This destruction could be linked to an aberrant T-cell-mediated immune response. Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) and programmed death-1 (PD-1) are immune checkpoints capable of downregulating T-cell immune functions. Read More

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http://dx.doi.org/10.1111/ijd.14983DOI Listing

Vitiligo-like depigmentation after chromoblastomycosis: a kind of postinflammatory depigmentation due to fungal infection.

Mycopathologia 2020 Jun 19. Epub 2020 Jun 19.

Department of Dermatology, Affiliated Hangzhou Third Hospital, Anhui Medical University, West Lake Rd 38, Hangzhou, 310009, People's Republic of China.

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http://dx.doi.org/10.1007/s11046-020-00468-3DOI Listing

Eruptive Halo Naevi: A Possible Indicator of Malignant Disease in a Case Series of Post-Adolescent Patients.

Acta Derm Venereol 2020 Jun 16. Epub 2020 Jun 16.

Department of Dermatology, Aarhus University Hospital, DK-8200 Aarhus N, Denmark. E-mail:

Halo naevi are considered benign. They occur in children and adolescents. Eruptive multiple halo naevi are infrequently seen in adults. Read More

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http://dx.doi.org/10.2340/00015555-3568DOI Listing

Pernicious Anemia and Vitiligo in an HIV Patient: An Unfamiliar Case Presentation.

Case Rep Gastrointest Med 2020 29;2020:7942453. Epub 2020 May 29.

Dermatology and Venereology Section, University Teaching Hospital, University of Zambia, School of Medicine, Lusaka, Zambia.

Pernicious anemia (PA) is a rarely considered cause of anemia in HIV-infected population and is seldom on the list of differential diagnoses. However, PA can have serious consequences if misdiagnosed or left untreated. We present the case of a 38-year-old HIV-positive man who was diagnosed with PA, which was preceded by a one-year history of vitiligo. Read More

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http://dx.doi.org/10.1155/2020/7942453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277020PMC

Clinico-Epidemiological Profile and Treatment Pattern of Vitiligo in Selected Dermatological Clinics of Mekelle City, Northern Ethiopia.

Dermatol Res Pract 2020 30;2020:3625753. Epub 2020 May 30.

Pharmacoepidemiology and Social Pharmacy Course and Research Unit, School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Tigray, Ethiopia.

Background: Vitiligo is not a well-studied disease in Ethiopia. Therefore, this study assessed its clinico-epidemiological profile and treatment patterns.

Methods: An institutional-based cross-sectional study was conducted in conveniently selected dermatologic clinics of Mekelle city, Ethiopia. Read More

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http://dx.doi.org/10.1155/2020/3625753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277066PMC

Long-Term Benefits of Daily Photo-Protection With a Broad-Spectrum Sunscreen in United States Hispanic Female Population.

J Drugs Dermatol 2020 Mar;19(3):236-242

aThe Vitiligo and Pigmentation Institute of Southern California, Los Angeles, CA bDepartment of Dermatology, Howard University, Washington, DC cL’Oreal Research and Innovation, Paris, France dL’Oreal Research and Innovation, Clark, NJ. Read More

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VitiVar: A locus specific database of vitiligo associated genes and variations.

Gene X 2019 Sep 11;3:100018. Epub 2019 May 11.

CSIR's Ayurgenomics Unit - TRISUTRA (Translational Research and Innovative Science ThRough Ayurgenomics), CSIR-IGIB, Mathura Road, Delhi, India.

Vitiligo is the most common skin pigmentation disorder which affects around 1% of the population worldwide. The disease has complex pathogenesis and is of multifactorial etiology, that finally culminates in patchy depigmentation of skin. Genetic contribution to the disease is well studied, however the information about multiple associated genes and contributing variations are scattered across the literature. Read More

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http://dx.doi.org/10.1016/j.gene.2019.100018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286000PMC
September 2019

Public Knowledge and Attitudes towards Vitiligo: A Survey in Mekelle City, Northern Ethiopia.

Dermatol Res Pract 2020 31;2020:3495165. Epub 2020 May 31.

Clinical Pharmacy Course and Research Unit, School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Tigray, Ethiopia.

Background: The overall well-being, sense of stigmatization, and treatment outcome of persons with vitiligo are largely dependent on their social acceptance and this is linked with perception and attitude of this disease in a given population. Therefore, this study assessed the knowledge and attitude of the public towards vitiligo.

Methods: A cross-sectional survey was carried out using a self-reported questionnaire distributed to adults living in Mekelle city, Northern Ethiopia from August to November 2019. Read More

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http://dx.doi.org/10.1155/2020/3495165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281839PMC

Intracellular virus sensor MDA5 exacerbates vitiligo by inducing the secretion of chemokines in keratinocytes under virus invasion.

Cell Death Dis 2020 Jun 12;11(6):453. Epub 2020 Jun 12.

Department of Dermatology, Xijing Hospital, Fourth Military Medical University, No 127 of West Changle Road, Xi'an, Shaanxi, 710032, China.

Vitiligo is a disfiguring disease featuring chemokines-mediated cutaneous infiltration of autoreactive CD8 T cells that kill melanocytes. Copious studies have indicated that virus invasion participates in the pathogenesis of vitiligo. IFIH1, encoding MDA5 which is an intracellular virus sensor, has been identified as a vitiligo susceptibility gene. Read More

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http://dx.doi.org/10.1038/s41419-020-2665-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293308PMC
June 2020
5.014 Impact Factor

Acquired hemophilia A and other autoimmune diseases after alemtuzumab therapy for multiple sclerosis: A report of two cases.

Mult Scler Relat Disord 2020 May 21;44:102181. Epub 2020 May 21.

Department of Internal Medicine, Universidade Federal de Minas Gerais. Instituto de Ensino e Pesquisa, Santa Casa de Misericórdia de Belo Horizonte, MG, Brazil.. Electronic address:

Alemtuzumab (ALZ) is an anti-CD52 monoclonal antibody used to treat recurrent remittent multiple sclerosis (RRMS). After ALZ infusion, there is a depletion of T and B cells expressing CD52, while the stem cells and innate immune cells are spared. Longitudinal studies with long periods of follow-ups have reported ALZ-associated autoimmune diseases, such as thrombocytopenic purpura and thyroiditis. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102181DOI Listing

Comorbidities in Pediatric Alopecia Areata.

J Eur Acad Dermatol Venereol 2020 Jun 12. Epub 2020 Jun 12.

Department of Dermatology and Plastic Surgery, Cleveland Clinic, Cleveland, Ohio, United States.

Background: Comorbidities are associated with higher health care costs, complex management, and poorer health outcomes. Identification and treatment of comorbid conditions in pediatric alopecia areata (AA) patients could provide an opportunity to improve health outcomes.

Objectives: To determine the prevalence of comorbidities among pediatric patients with AA using a large de-identified aggregated patient database. Read More

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http://dx.doi.org/10.1111/jdv.16727DOI Listing

Comparative study between follicular unit transplantation with intact and unintact hair bulb in treatment for stable vitiligo.

J Dermatolog Treat 2020 Jun 12:1-16. Epub 2020 Jun 12.

Department of Dermatosurgery and Hair Disease Center, Shanghai Skin Disease Hospital, Shanghai, China.

Objective: To compare the cosmetic efficacy of transplantation of follicles with intact and unintact hair bulbs in the treatment for vitiligo.

Methods: The single-hair follicle units with intact hair bulbs and un-intact hair bulbs were transplanted into skin of vitiligo. The diameters of regrowing hair shafts and repigmentation of implanted follicles were detected analyzed by dermatoscopy (Beining BN-PFMF Skin and Hair Visualizer). Read More

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http://dx.doi.org/10.1080/09546634.2020.1782320DOI Listing
June 2020
1.764 Impact Factor

Associations of Angiotensin-Converting Enzyme Gene Insertion/Deletion (ACE Gene I/D) Polymorphism With Vitiligo: An Updated Systematic Review and Meta-Analysis.

Cureus 2020 May 10;12(5):e8046. Epub 2020 May 10.

Dermatology, College of Medicine King Saud Bin Abdulaziz, University for Health Sciences, Riyadh, SAU.

Objective The objective of the article is to summarize the current evidence regarding the association between angiotensin-converting enzyme insertion/deletion (ACE I/D) gene polymorphism and vitiligo disease. Methods A computerized search was performed through four electronic databases (PubMed, Scopus, Cochrane Central Register of Controlled Trials [CENTRAL], and Web of Science) with the relevant keywords. Included studies comprised of papers examining the association of ACE gene polymorphisms with vitiligo. Read More

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http://dx.doi.org/10.7759/cureus.8046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282372PMC

Inflammasomes in Common Immune-Related Skin Diseases.

Front Immunol 2020 12;11:882. Epub 2020 May 12.

Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei, China.

The inflammasome is an important protein complex that cleaves the proinflammatory cytokines pro-IL-1β and pro-IL-18 into their active forms. Owing to its critical role in eliciting innate immune responses, IL-1β has been suggested to contribute to various skin diseases, including psoriasis, vitiligo, systemic lupus erythematosus (SLE), and atopic dermatitis (AD). Recently, several types of activators and inhibitors of different inflammasomes, as well as inflammasome-related genes and genetic susceptibility loci, have been identified in these immune-related common skin diseases. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247819PMC

Association between immune-related adverse events and efficacy of PD-1 inhibitors in Chinese patients with advanced melanoma.

Aging (Albany NY) 2020 Jun 8;12(11):10663-10675. Epub 2020 Jun 8.

Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.

Programmed cell death 1 (PD-1) checkpoint inhibitor therapy leads to immune-related adverse events (irAEs). We sought to evaluate whether the development of irAEs correlates with the treatment response in Chinese patients with advanced melanoma. In this study, we conducted a retrospective study of advanced melanoma patients who received PD-1 inhibitor therapy in China between August 2014 and March 2018. Read More

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http://dx.doi.org/10.18632/aging.103285DOI Listing

Retinal nerve fiber layer, retinal pigment epithelium, and choroidal thickness in vitiligo patients.

J Cosmet Dermatol 2020 Jun 9. Epub 2020 Jun 9.

Department of Dermatology, University of Health Sciences Gazi Yaşargil Education Research Hospital, Diyarbakir, Turkey.

Background: Vitiligo is one of the common pigmentary disorders affecting the ocular structures.

Aim: To determine the retinal nerve fiber layer (RNFL), retinal pigment epithelium (RPE), and choroidal thickness (CT) in vitiligo patients and to evaluate the relationship between choroidal thickness and vitiligo subtypes.

Methods: The right eyes of 106 participants (51 vitiligo, 55 nonvitiligo) were included in the study. Read More

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http://dx.doi.org/10.1111/jocd.13367DOI Listing

Off-label studies on ruxolitinib in dermatology: a review.

J Dermatolog Treat 2020 Jun 9:1-7. Epub 2020 Jun 9.

Division of Dermatology, Harbor-UCLA Medical Center, Torrance, CA, USA.

Ruxolitinib is a Janus kinase (JAK) inhibitor that is FDA-approved for the treatment of myelofibrosis, polycythemia vera, and acute graft-versus-host disease. Its use in treating various dermatologic diseases has been a topic of growing interest due to its favorable safety profile and targeted inhibition of several cytokines that perpetuate inflammatory skin conditions. The PubMed/MEDLINE and ClinicalTrials. Read More

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http://dx.doi.org/10.1080/09546634.2020.1773385DOI Listing

VIRdb: a comprehensive database for interactive analysis of genes/proteins involved in the pathogenesis of vitiligo.

PeerJ 2020 21;8:e9119. Epub 2020 May 21.

Amity Institute of Biotechnology, Amity University, Uttar Pradesh, India.

Vitiligo is a chronic asymptomatic disorder affecting melanocytes from the basal layer of the epidermis which leads to a patchy loss of skin color. Even though it is one of the neglected disease conditions, people suffering from vitiligo are more prone to psychological disorders. As of now, various studies have been done in order to project auto-immune implications as the root cause. Read More

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http://dx.doi.org/10.7717/peerj.9119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246032PMC

Chronic Atrophic Gastritis with Negative Intrinsic Factor and Parietal Cell Antibody Presenting as a Severe Hemolytic Anemia.

Case Rep Hematol 2020 15;2020:8697493. Epub 2020 May 15.

Medical University of South Carolina, Department of Internal Medicine, Charleston, SC, USA.

A 28-year-old Caucasian male with Hashimoto's disease and vitiligo presented with two weeks of dizziness on exertion following pharyngitis which was treated with prednisone 40 mg by mouth once a day for five days. Initial workup revealed anemia, elevated lactate dehydrogenase (LDH), and low haptoglobin. He underwent workup for causes of hemolytic anemia which was remarkable for a peripheral blood smear with hypersegmented neutrophils and low vitamin B12 levels concerning for pernicious anemia. Read More

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http://dx.doi.org/10.1155/2020/8697493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245653PMC

Skin - a vast organ with immunological function (Review).

Exp Ther Med 2020 Jul 20;20(1):18-23. Epub 2020 Mar 20.

Department of Physiology, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.

The skin is an organ with multiple functions, where important inflammatory and immunological processes take place. The integrity of the skin barrier is necessary for it to fulfill its roles. An intact skin barrier requires a physiological keratinization process, but also a normal cutaneous microbial flora. Read More

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http://dx.doi.org/10.3892/etm.2020.8619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271707PMC
July 2020
0.941 Impact Factor

Chemical-Associated Vitiligo.

Mayo Clin Proc 2020 Jun;95(6):1105-1106

Department of Dermatology, Mayo Clinic, Rochester, MN. Electronic address:

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http://dx.doi.org/10.1016/j.mayocp.2020.02.012DOI Listing

Selenium levels and skin diseases: systematic review and meta-analysis.

J Trace Elem Med Biol 2020 May 20;62:126548. Epub 2020 May 20.

Department of Dermatology, The Central Hospital of Enshi Autonomous Prefecture, Enshi 445000, China. Electronic address:

Background: Several studies have investigated the association between selenium levels and skin diseases, but reached inconsistent results.

Objective: This systematic review and meta-analysis was conducted to evaluate the association between selenium levels and skin diseases.

Methods: A systematic search was conducted in public databases to identify all relevant studies, and study-specific standard mean differences (SMD) and 95% confidence intervals (CI) were pooled to compare the selenium levels between different groups. Read More

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http://dx.doi.org/10.1016/j.jtemb.2020.126548DOI Listing

A novel point of care technique to improve graft uptake in melanocyte-keratinocyte transplantation procedure for vitiligo of contoured areas like external ear.

J Am Acad Dermatol 2020 Jun 1. Epub 2020 Jun 1.

Bangalore Medical College and Research Institute, KR Road, Bengaluru - 560002, India.

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http://dx.doi.org/10.1016/j.jaad.2020.05.117DOI Listing

Repigmentation of vitiligo with oral baricitinib.

Australas J Dermatol 2020 Jun 3. Epub 2020 Jun 3.

Skin Health Institute, Carlton, Victoria, Australia.

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http://dx.doi.org/10.1111/ajd.13348DOI Listing

Follicular Transplantation, Microneedling, and Adjuvant Narrow-band Ultraviolet-B Irradiation as Cost-Effective Regimens for Palmar-Plantar Vitiligo: A Pilot Study.

Cureus 2020 Apr 28;12(4):e7878. Epub 2020 Apr 28.

Life Sciences, Biofort Corp., Guaynabo, PRI.

Treatment of refractory palmar-plantar vitiligo is particularly challenging because the skin in these regions has a limited supply of follicle-derived melanocytic stem cells. Autologous hair transplantation monotherapy is effective in some forms of vitiligo through the provision of melanocytic stem cells. CO laser followed by exposure to light (i. Read More

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http://dx.doi.org/10.7759/cureus.7878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255558PMC

Increased risk of endocrine autoimmunity in first-degree relatives of patients with autoimmune Addison's disease.

Eur J Endocrinol 2020 Jul;183(1):73-81

Department of Paediatric Diabetes and Obesity, Poznan University of Medical Sciences, Poznan, Poland.

Objective: Autoimmune conditions tend to cluster in subjects with Addison's disease (AD) and probably also among their relatives. The aim of the study was to estimate the frequency of the endocrine gland-specific autoantibodies in first-degree relatives of patients with AD.

Methods: Autoantibodies were investigated in 113 family members using RIA and ELISA assays. Read More

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http://dx.doi.org/10.1530/EJE-20-0150DOI Listing

Simultaneous Bullous Pemphigoid and Vitiligo Associated with Adalimumab Therapy in a Patient with Psoriasis Vulgaris.

Indian Dermatol Online J 2020 Mar-Apr;11(2):229-231. Epub 2020 Mar 9.

Department of Dermatology, Hospital General de México, Ciudad de México, CDMX, Mexico.

Antitumor necrosis factors (TNFs) agents are increasingly being used for the effective treatment of diverse diseases. Due to its extensive use and longer duartion of treatment, there are a growing number of reports of the development of autoimmune conditions such as systemic lupus erythematosus, bullous pemphigoid (BP), and vitiligo associated with the use of anti-TNF agents. We describe a patient who developed BP as well as vitiligo after receiving treatment with adalimumab for plaque psoriasis. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_53_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247621PMC

Effective use of oral tofacitinib and phototherapy in a patient with concomitant alopecia areata, vitiligo, and plaque and inverse psoriasis.

Clin Case Rep 2020 May 27;8(5):819-822. Epub 2020 Feb 27.

Department of Dermatology Warren Alpert Medical School Brown University Providence RI USA.

This case presentation suggests that tofacitinib combined with phototherapy may be an effective treatment option for patients with concomitant alopecia areata, vitiligo, and different phenotypes of psoriasis including plaque and inverse psoriasis. Read More

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http://dx.doi.org/10.1002/ccr3.2759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250974PMC