8,835 results match your criteria Vitiligo


Chemical Profiling of Kaliziri Injection and Quantification of Six Caffeoyl Quinic Acids in Beagle Plasma by LC-MS/MS.

Pharmaceuticals (Basel) 2022 May 25;15(6). Epub 2022 May 25.

State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China.

Vitiligo is a stubborn multifactorial skin disease with a prevalence of approximately 1% in the global population. Kaliziri, the seeds of (L.) Willd. Read More

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Anticancer treatments and photosensitivity.

Authors:
V Sibaud

J Eur Acad Dermatol Venereol 2022 Jun;36 Suppl 6:51-58

Oncodermatology Department, Claudius REGAUD Institute and Cancer University Institute, Toulouse Oncopole, Toulouse Cedex 9, France.

Drug-induced photosensitivity is associated with a wide range of anticancer treatments, including conventional chemotherapeutic agents, targeted anticancer therapies, and immune checkpoint inhibitors. These dermatologic adverse events can have a major impact on the well-being and quality of life of cancer patients, leading to dose modifications and interruption or discontinuation of anticancer treatments in severe cases. However, the heterogeneous nature of the photosensitive reactions induced by these agents, as well as the common concomitant use of other potentially photosensitizing drugs (antibiotics, voriconazole, nonsteroidal anti-inflammatory drugs, etc. Read More

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Lipopolysaccharide reduces melanin synthesis in vitiligo melanocytes by regulating autophagy.

Exp Dermatol 2022 Jun 22. Epub 2022 Jun 22.

Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Vitiligo is an autoimmune-related disease with a complex aetiology that involves innate immunity. Toll-like receptors (TLRs) are important parts of innate immunity and are related to a variety of autoimmune diseases, including vitiligo, through an unknown mechanism. In this study, we found that the TLR4 gene expression was increased in blood samples of patients with advanced stage vitiligo, and then we evaluated the effect of TLR4 ligand lipopolysaccharide (LPS) on melanin synthesis in a vitiligo melanocyte cell line PIG3V and along with its mechanism. Read More

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Repigmentation in two patients with vitiligo on AcEGCG 0.5% cream.

Clin Exp Dermatol 2022 Jun 22. Epub 2022 Jun 22.

Department of Dermatology, Hangzhou Third People's Hospital, Hangzhou, China.

Per-acetylated epigallocatechin-3-gallate (AcEGCG), a fully acetylated derivative of EGCG, a more potent agent for protection of melanocytes from oxidative damage. We present two patients with vitiligo treated with AcEGCG 0.5% cream, who demonstrated skin repigmentation and control of depigmentation progression. Read More

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Psoralea corylifolia L. seed extract attenuates dexamethasone-induced muscle atrophy in mice by inhibition of oxidative stress and inflammation.

J Ethnopharmacol 2022 Jun 18:115490. Epub 2022 Jun 18.

College of Pharmacy and Gachon Institute of Pharmaceutical Science, Gachon University, Incheon, 21936, Republic of Korea; Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, 21999, Republic of Korea; Gachon Medical Research Institute, Gil Hospital, Incheon, 21565, Republic of Korea. Electronic address:

Ethnopharmacological Relevance: The seeds of Psoralea corylifolia (PCS), also called "Boh-Gol-Zhee" in Korean, have been used in traditional medicine. PCS is effective for the treatment of vitiligo, cancer, inflammatory diseases, neurodegenerative diseases, kidney diseases, and musculoskeletal diseases.

Aim Of The Study: In this study, we validated the beneficial effects of PCS extract on dexamethasone (DEX)-induced muscle atrophy in mice. Read More

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Melanocyte Adhesion and Apoptosis in Vitiligo: Linking Puzzle Blocks.

Curr Mol Med 2022 Jun 21. Epub 2022 Jun 21.

Department of Dermatology, Venereology and Leprosy, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Vitiligo is the utmost common depigmenting condition consequential from melanocyte loss from the basal layer of the epidermis. Vitiligo disease mostly affects dark-skinned races and made them more sensitive to UV radiation. It is also linked with some autoimmune diseases and various psychosocial difficulties. Read More

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Exceptional response to combination ipilimumab and nivolumab in metastatic uveal melanoma: Insights from genomic analysis.

Melanoma Res 2022 Jun 17. Epub 2022 Jun 17.

Department of Medical Oncology, BC Cancer.

Uveal melanoma is the most common intraocular malignancy and has a poor prognosis compared to other melanoma subtypes with a median overall survival of 6-10 months. With immune checkpoint inhibitor therapy, either PD-1 inhibitor alone or combination ipilimumab/nivolumab (anti-CTLA-4/anti-PD-1), responses are rare and often not durable. We present a case report of a now 66-year-old woman with diffuse metastatic uveal melanoma previously treated with a combination of ipilimumab/nivolumab, followed by maintenance nivolumab. Read More

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Assessment of prostaglandin F2-alpha (PGF2α) in lesional and nonlesional skin of vitiligo patients.

Int J Dermatol 2022 Jun 21. Epub 2022 Jun 21.

Dermatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Background: F2-isoprostane is one of the members of biologically active prostaglandins. It is considered a reliable marker of oxidative stress. This study aimed at investigating and studying the hypothesis of the possible role of prostaglandin F2-alpha (PGF2α) in the pathogenesis of vitiligo and to know if there is a possibility of using it in therapy. Read More

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Inducible Nitric Oxide Synthase iNOS-954-G>C and Ex16+14-C>T Gene Polymorphisms and Susceptibility to Vitiligo in the Saudi Population.

Pharmgenomics Pers Med 2022 13;15:603-612. Epub 2022 Jun 13.

Scientific Research Center, Health service directorate, Riyadh, Saudi Arabia.

Objective: Vitiligo is an acquired pigmentary skin disorder with regional disappearance of melanocytes. Multigenic inheritance has been proposed in the pathogenesis of vitiligo. The present study aimed to investigate the possible association of inducible nitric oxide synthase polymorphisms iNOS-954-G/C (rs1800482 G>C) and iNOS-Ex16+14-C/T (rs2297518 C>T) with vitiligo in the Saudi population, if any. Read More

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A deep learning-based hybrid artificial intelligence model for the detection and severity assessment of vitiligo lesions.

Ann Transl Med 2022 May;10(10):590

Department of Cosmetic Laser Surgery, Hospital for Skin Disease and Institute of Dermatology, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, Nanjing, China.

Background: We aimed to establish and validate a deep learning-based hybrid artificial intelligence (AI) model for the objective morphometric and colorimetric assessment of vitiligo lesions.

Methods: Two main datasets containing curated images of vitiligo lesions from Chinese patients (Fitzpatrick skin types III or IV) were established, including one with 2,720 images for lesion localization study and the other with 1,262 images for lesion segmentation study. Besides, an additional test set containing 145 images of vitiligo lesions from other Fitzpatrick skin types (I, II, or V) was also generated. Read More

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The Efficacy and Psychoneuroimmunology Mechanism of Camouflage Combined With Psychotherapy in Vitiligo Treatment.

Front Med (Lausanne) 2022 27;9:818543. Epub 2022 May 27.

Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

Background And Objectives: The efficacy of camouflage combined with psychotherapy and the underlying mechanisms are poorly understood in vitiligo management. This study aimed to investigate the joint efficacy and further explore psycho-neuro-endocrine-immune-skin interactions.

Patients And Methods: In a prospective, non-randomized and concurrent controlled trial, patients were divided into two groups. Read More

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Occurrence of inflammatory bowel disease in patients with chronic inflammatory skin diseases: a cohort study.

Br J Dermatol 2022 Jun 19. Epub 2022 Jun 19.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Background: Several studies linked various chronic inflammatory skin diseases (CISDs) with inflammatory bowel disease (IBD) in a range of data sources with mixed conclusions.

Objective: We compared the incidence of IBD-ulcerative colitis (UC) and Crohn's disease (CD)- in patients with a CISD versus similar persons without a CISD.

Methods: In this cohort study using nationwide, longitudinal, commercial insurance claims data from the US, we identified adults and children who were seen by a dermatologist between 2004-2020, and diagnosed with either psoriasis, atopic dermatitis, alopecia areata, vitiligo, or hidradenitis suppurativa. Read More

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Evaluation of Combination use of phenytoin Cream 1% and Fractional CO laser in Treatment of Stable Non-Segmental Vitiligo: A Pilot Study.

Dermatol Ther 2022 Jun 14:e15635. Epub 2022 Jun 14.

Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Vitiligo is an autoimmune disorder of melanocyte characterized by macular and depigmented patches. There are several treatment modalities for this disease, including the use of corticosteroids, calcineurin inhibitors, vitamin D analogous and topical phenytoin. Combination therapy utilizing fractional CO laser with different topical agents has been used to enhance treatment response with promising results. Read More

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Drug delivery of natural products through nanocarriers for effective vitiligo therapy: A compendia Review.

J Cosmet Dermatol 2022 Jun 14. Epub 2022 Jun 14.

Department of Pharmacognosy and Phytochemistry, School of pharmaceutical education and research, Jamia Hamdard, New Delhi.

Vitiligo is a depigmenting illness that causes white areas on the skin. Vitiligo's pathogenetic genesis is based on the melanocyte's autoimmune destruction, in which oxidative stress causes melanocyte molecular, organelle, and exposure of antigen, as well as melanocyte cell death, and so plays a role in vitiligo progression. Natural compounds have recently shown a wide range of therapeutic bioactivities against a number of skin disorders, and this study focuses on natural compounds' effects and processes on vitiligo models. Read More

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Autoimmune polyendocrine syndrome type 1: Clinical manifestations, pathogenetic features, and management approach.

Autoimmun Rev 2022 Jun 9;21(8):103135. Epub 2022 Jun 9.

Semey Medical University, Semey, Kazakhstan; CONEM Kazakhstan Environmental Health and Safety Research Group, Semey Medical University, Semey, Kazakhstan.

Autoimmune polyendocrine syndrome type 1 (APS-1) is an autosomal recessive hereditary pathology that develops with endocrine and non-endocrine manifestations in childhood. The classic triad of APS-1 includes chronic candidiasis of the skin and mucous membranes, adrenal insufficiency, and hypoparathyroidism. APS-1 is often accompanied by hypogonadism, type 1 diabetes, autoimmune thyroiditis, vitiligo, alopecia, asplenia, pneumonitis, gastritis, pernicious anemia, and intestinal dysfunction, nephritis, and hepatitis. Read More

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Circulating Exosomal miR-493-3p Affects Melanocyte Survival and Function by Regulating Epidermal Dopamine Concentration in Segmental Vitiligo.

J Invest Dermatol 2022 Jun 8. Epub 2022 Jun 8.

Department of Dermatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

Circulating exosomal miRNAs have been used as potential biomarkers for various disorders. However, to date, the miRNA expression profile of circulating exosomes in patients with segmental vitiligo (SV) has not been identified. Thus, we aimed to identify the expression profile of circulating exosomal miRNAs and investigate their role in the pathogenesis of SV. Read More

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Risk of internal malignancies, cutaneous malignant melanoma and non-melanoma skin cancer among patients with vitiligo: a systematic review and meta-analysis.

J Eur Acad Dermatol Venereol 2022 Jun 10. Epub 2022 Jun 10.

Division of Dermatology, Department of Medicine, National University Healthcare System, Singapore, Singapore.

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Worsening Quality of Life in Young Adult, Highly Educated, and Married Female Patients with Vitiligo: A Hospital-Based Case Control Study in Taiwan.

Int J Environ Res Public Health 2022 May 31;19(11). Epub 2022 May 31.

Department of Dermatology, Changhua Christian Hospital, Changhua 50006, Taiwan.

Vitiligo is an acquired chronic depigmentation disorder that can have a negative impact on the quality of life (QoL). This is especially true for patients with non-white skin. Only few studies have investigated the QoL of Asian patients with vitiligo. Read More

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Impacts of exposure to topical calcineurin inhibitors on metabolism in vitiligo infants.

Pediatr Res 2022 Jun 9. Epub 2022 Jun 9.

Department of Dermatology, Hangzhou Third People's Hospital, Affiliated Hangzhou Dermatology Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Background: Tacrolimus ointment is a recently developed topical immunomodulator that has been approved for use in patients with vitiligo older than 2 years. Concern regarding potential systemic toxic effects has limited treatment options for children younger than 2 years. We wanted to determine whether topical tacrolimus therapy is safe and effective in patients with vitiligo younger than 2 years. Read More

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The Use of Bakuchiol in Dermatology: A Review of In Vitro and In Vivo Evidence.

J Drugs Dermatol 2022 Jun;21(6):624-629

The plant Psoralea corylfolia contains compounds such as psoralens that are useful for the treatment of psoriasis and vitiligo, and the plant is used in Chinese and Indian traditional medicine for diseases such as psoriasis and leprosy. Bakuchiol, a meroterpene phenol in Psoralea corylfolia, has similar functional properties to topical retinoids, which are commonly used to treat acne, post-inflammatory hyperpigmentation, and wrinkles. Bakuchiol’s anti-inflammatory and anti-proliferative properties also may lead to improvement in psoriasis and skin cancers, yet more clinical evidence is needed to elucidate these effects. Read More

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New-onset vitiligo following COVID-19 disease.

Skin Health Dis 2022 Mar 28;2(1):e86. Epub 2022 Jan 28.

Department of Dermatology Di.S.Sal. San Martino Polyclinic Hospital IRCCS University of Genoa Genoa Italy.

Background: Coronavirus disease 2019 (COVID-19) disease and vaccines have been associated to various skin reactions, which are mostly similar amongst them. New onset of vitiligo and hypopigmentations have been described following COVID-19 vaccination, but never after COVID-19 infection.

Objectives: We present the case of a 45-year-old woman, who developed vitiligo 2 weeks after COVID-19 disease. Read More

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Baricitinib is Effective in Treating Progressing Vitiligo in vivo and in vitro.

Dose Response 2022 Apr-Jun;20(2):15593258221105370. Epub 2022 May 31.

Department of Dermatology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Objective: To evaluate the clinical efficacy and safety of baricitinib, a Janus kinase (JAK) inhibitor, in treating patient with progressing vitiligo, and to further explore the regulation of baricitinib on melanocytes (MCs) in vitro.

Methods: Four patients with progressing vitiligo were treated with oral baricitinib for a total of 12 weeks. MCs were cultured in vitro and irradiated by high-dose ultraviolet B (UVB, 150mJ/cm) to make an MC damaged model (MC-Ds). Read More

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Tertiary Health Care-Based Randomized Controlled Study to Compare Autologous, Non-cultured, Non-trypsinized Epidermal Cell Transplant (Jodhpur Technique) with Split-Thickness Skin Grafting (STSG) in Stable Vitiligo.

J Cutan Aesthet Surg 2022 Jan-Mar;15(1):33-39

Department of Dermatology, Venereology & Leprosy, Dr. SN Medical College, Jodhpur, Rajasthan, India.

Background: Surgical treatment of vitiligo is reserved for stable recalcitrant vitiligo patches. Split-thickness skin grafting (STSG) is an important established modality for the surgical treatment of vitiligo, whereas autologous, non-cultured, non-trypsinized epidermal cell transplant, also known as Jodhpur technique (JT), is an unconventional innovative surgical modality for the treatment of stable vitiligo.

Aims: To compare the two techniques, JT and STSG, with regards to the extent and pattern of repigmentation achieved, color matching of the repigmented area, patient satisfaction (Dermatology Life Quality Index [DLQI] questionnaire and patient global assessment), and adverse events (if any) in patients with stable vitiligo. Read More

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Multimodal analyses of vitiligo skin identifies tissue characteristics of stable disease.

JCI Insight 2022 Jun 2. Epub 2022 Jun 2.

Department of Dermatology, University of California, Irvine, Irvine, United States of America.

Vitiligo is an autoimmune skin disease characterized by the destruction of melanocytes by autoreactive CD8+ T cells. Melanocyte destruction in active vitiligo is mediated by CD8+ T cells but why white patches in stable disease persist is poorly understood. The interaction between immune cells, melanocytes, and keratinocytes in situ in human skin has been difficult to study due to the lack of proper tools. Read More

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Uses of eye drops in dermatology, literature review.

J Dermatolog Treat 2022 Jun 2:1-13. Epub 2022 Jun 2.

Department of Dermatology and Venereology, Faculty of Medicine, Tanta University, Tanta, Egypt.

Since medication absorption through the skin and eye tissue seems similar, commercially available eye-drops could be used to treat skin diseases when topical therapies are unavailable or unaffordable. The FDA-approved and off-label applications of various eye drops used as topical treatments in dermatological clinical practice were highlighted in this review. A thorough PubMed and Google Scholar library search using various combinations of the keywords (Eye drop, ocular solution, conjunctival installation, and skin diseases, topical, local, beta-blockers, prostaglandin, cyclosporin, apraclonidine, atropine, oxymetazoline). Read More

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Differentially Expressed Circular RNAs and Their Therapeutic Mechanism in Non-segmental Vitiligo Patients Treated With Methylprednisolone.

Front Med (Lausanne) 2022 16;9:839066. Epub 2022 May 16.

Department of Dermatology, Children's Hospital of Nanjing Medical University, Nanjing, China.

Vitiligo is characterized by chronic skin depigmentation arising from the autoimmune destruction of epidermal melanocytes. Systemic corticosteroid therapy is an effective immunosuppressive treatment for progressive generalized vitiligo. Circular RNAs (circRNAs) play various roles in diseases. Read More

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Ribociclib-induced Vitiligo: a Case Report.

Dermatol Pract Concept 2022 May 1;12(2):e2022045. Epub 2022 Apr 1.

Department of Dermatology, Hospital Universitario Severo Ochoa, Leganés (Madrid), Spain.

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Assessment of ADAM17 and ADAM10 proteins with CXCL10 and thyroid autoimmunity in vitiligo pathogenesis.

Postepy Dermatol Alergol 2022 Apr 9;39(2):397-400. Epub 2022 May 9.

Department of Dermatology, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.

Introduction: Vitiligo is an acquired chronic pigmentation disorder. The etiopathogenesis is still not fully understood.

Aim: To research the correlation of ADAM proteins, shown to be associated with autoimmune diseases like rheumatoid arthritis and lupus erythematosus, with vitiligo also considered to be an autoimmune disease. Read More

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