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    1 OF 136

    Association of human beta-defensin 1 gene polymorphisms with nonsegmental vitiligo.
    Clin Exp Dermatol 2018 Jun 20. Epub 2018 Jun 20.
    Faculty of Chemical and Biological Sciences, Autonomous University of Sinaloa, Culiacan, Sinaloa, Mexico.
    Background: Vitiligo is a pigmentation disorder of autoimmune aetiology. Polymorphisms in beta-defensin genes have been linked to a predisposition to some autoimmune disorders.

    Aim: To evaluate the role of polymorphisms in DEFB1, the gene encoding for human beta-defensin (HBD)-1 and its 5' untranslated region in nonsegmental vitiligo. Read More

    Neural and Endocrinal Pathobiochemistry of Vitiligo: Comparative Study for a Hypothesized Mechanism.
    Front Endocrinol (Lausanne) 2018 25;9:197. Epub 2018 Apr 25.
    Dermatology, Andrology and STDs Department, Faculty of Medicine, Al-Azhar University, Assuit Branch, Assuit, Egypt.
    The etiology of vitiligo is still unclear. The aim is to investigate a neural and hormonal etio-pathology of vitiligo. Sixty acrofacial vitiligo patients were divided into two subgroups as active vitiligo patients group (AVPs;  = 35) and stable vitiligo patients group (SVP;  = 25). Read More

    Motorized 0.8 mm micro-punch grafting for refractory vitiligo: A retrospective study of 230 cases.
    J Am Acad Dermatol 2018 Jun 15. Epub 2018 Jun 15.
    Eureka Skin & Laser Clinic, Seoul, Korea. Electronic address:
    Background: Punch grafting for vitiligo has been time-consuming and may result in cobblestone-like appearances. We devised a motorized 0.8 mm micro-punch grafting procedure to overcome these limitations. Read More

    Zosteriform Lichen Planus Pigmentosus Altering Segmental Vitiligo.
    Skinmed 2018 1;16(2):133-135. Epub 2018 Apr 1.
    Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
    A 22-year-old student presented with a 3-year history of hyperpigmented, minimally pruritic skin lesions over his trunk. They had begun as small discrete macules over the left side of the trunk, with some coalescing to form patches. He had had right-sided segmental vitiligo (SV) for the previous 7 to 8 years (Figure 1A), and this had started to cross the midline, covering a margin over the left side of the chest and back. Read More

    Herbal sun protection agents: Human studies.
    Clin Dermatol 2018 May - Jun;36(3):369-375. Epub 2018 Mar 21.
    Department of Dermatology, SUNY Downstate Medical Center, Brooklyn, NY.
    Topical sunscreens are the mainstay for protection from ultraviolet (UV) radiation. With skin cancer rates on the rise and great interest in reversing or preventing the effects of photoaging, new molecules with potential to defend against UV damage have received a great deal of attention. Specifically, there is a growing interest in herbal substances that offer protection against the damaging effects of UV rays. Read More

    Russian traditional medicine in dermatology.
    Clin Dermatol 2018 May - Jun;36(3):325-337. Epub 2018 Mar 13.
    Rakhmanov Department of Dermatology and Venereal Diseases at the First Moscow State Sechenov Medical University of the Russian Federation, Moscow, Russia; Institute of Medical and Social Technologies, Postgraduate Medical School, Department of Dermatology, Venereology and Cosmetology, Moscow State University of Food Production, Moscow, Russia; Department of Dermatology, Bedford Hospital, Bedford, UK. Electronic address:
    The use of herbal remedies for various medical issues is becoming increasingly commonplace in all fields of medicine, and dermatology is no exception. This review focuses on traditional dermatologic herbal remedies, commonly used in Russia, as the rich array of 11 different plant zones has resulted in a great variety of medicinal plants. Herbal remedies warrant deeper investigation and research, especially due to their active substance content, which may interfere with or reinforce the effect of modern medications, something that medical professionals should be aware of when prescribing treatments. Read More

    [The network pharmacological mechanisms of four anti-vitiligo Uyghur medicines based on Phlegmatic temperament theory].
    Zhongguo Zhong Yao Za Zhi 2018 May;43(9):1780-1788
    Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, School of Pharmacy, Shihezi University, Shihezi 832002, China.
    To explore the network pharmacological mechanisms of four anti-vitiligo Uyghur medicines based on the Phlegmatic temperament theory. First, The anti-vitiligo Uyghur medicine formulas based on Phlegmatic temperament theory were collected. The pharmacokinetic characteristic of main compounds in four anti-vitiligo Uyghur medicines were obtained by using admetSAR. Read More

    Vitiligo remitting with tocilizumab.
    J Eur Acad Dermatol Venereol 2018 Jun 10. Epub 2018 Jun 10.
    University College London Hospitals, London, UK.
    A 61 year-old physician with seronegative rheumatoid arthritis (~4-5 years) and vitiligo (~6-7 years) was started on treatment with tocilizumab - an anti-interleukin-6 (IL-6) receptor humanised monoclonal antibody. He had failed to respond to hydroxychloroquine, sulphasalazine, methyl-prednisolone, methotrexate and etanercept. The arthritis proved refractory to tocilizumab (6 months). Read More

    Medical uses of (Safflower): a comprehensive review from Traditional Medicine to Modern Medicine.
    Electron Physician 2018 Apr 25;10(4):6672-6681. Epub 2018 Apr 25.
    PhD Student, Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
    Background: , known as Kafesheh (Persian) and safflower (English) is vastly utilized in Traditional Medicine for various medical conditions, namely dysmenorrhea, amenorrhea, postpartum abdominal pain and mass, trauma and pain of joints. It is largely used for flavoring and coloring purposes among the local population. Recent reviews have addressed the uses of the plant in various ethnomedical systems. Read More

    Beyond Traditional Treatment: The Importance of Psychosocial Therapy in Vitiligo.
    J Drugs Dermatol 2018 Jun;17(6):688-691
    Vitiligo is an acquired depigmentation disorder of the skin. Patients with vitiligo often face a challenging disease course, having to cope with a condition that is known to be physically disfiguring, psychologically devastating, and socially stigmatizing. Although an extensive amount of research has been directed towards the dermatologic treatment of vitiligo, an overall lack of data exists investigating treatment of the psychological and emotional burden of patients with vitiligo. Read More

    and Gene Polymorphism in Turkish Vitiligo Patients.
    Balkan J Med Genet 2017 Dec 29;20(2):67-74. Epub 2017 Dec 29.
    Department of Genetics, Faculty of Medicine, Ege University, Izmir, Turkey.
    Vitiligo is an acquired disease of unknown etiology. Several theories have been proposed to understand the pathogenesis. The role of oxidative stress has been getting more important in recent years. Read More

    Vitiligo: Patient stories, self-esteem, and the psychological burden of disease.
    Int J Womens Dermatol 2018 Mar 8;4(1):32-37. Epub 2018 Jan 8.
    Keck School of Medicine, University of Southern California, Los Angeles, CA.
    Vitiligo is a relatively common disorder that is characterized by depigmented patches of skin. Multiple studies characterize the overwhelming psychological burden that is experienced by many patients around the globe. This review examines personal patient stories and the impacts of age, culture, sex, race, and ethnicity in relationship to altered self-esteem and quality of life in patients who live with vitiligo. Read More

    Bimatoprost in Dermatology.
    Indian Dermatol Online J 2018 May-Jun;9(3):224-228
    Department of Skin and V.D, Patna Medical College and Hospital, Patna, Bihar, India.
    Bimatoprost is a prostamide analogue used for treatment of glaucoma in ophthalmology. Surprisingly, the side effects such as increased pigmentation of eyelids and hypertrichosis in patients being treated with prostaglandin analogues for glaucoma have opened new areas of application in various dermatological disorders such as alopecia mainly affecting eyelashes, eyebrows, and vitiligo. Read More

    High correlation between skin color based on CIELAB color space, epidermal melanocyte ratio, and melanocyte melanin content.
    PeerJ 2018 24;6:e4815. Epub 2018 May 24.
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, R.O.C.
    Background: To treat skin color disorders, such as vitiligo or burns, melanocytes are transplanted for tissue regeneration. However, melanocyte distribution in the human body varies with age and location, making it difficult to select the optimal donor skin to achieve a desired color match. Determining the correlations with the desired skin color measurement based on CIELAB color, epidermal melanocyte numbers, and melanin content of individual melanocytes is critical for clinical application. Read More

    Decreased choroidal thickness in vitiligo patients.
    BMC Ophthalmol 2018 May 29;18(1):126. Epub 2018 May 29.
    Department of Dermatology and Venerology, Kirikkale University Faculty of Medicine, Yenisehir District, Tahsin Duru Avenue, No:14, Yahsihan, Kirikkale, Turkey.
    Background: Vitiligo is a disease characterized by depigmented macules and patches that occur as a result of the loss of functional melanocytes from the affected skin through a mechanism which has not been elucidated yet. Destruction of pigment cells in vitiligo may not remain limited to the skin; the eyelashes, iris, ciliary body, choroid, retinal pigment epithelium and meninges may also be affected. This study aims to compare the choroidal thickness of patients with and without vitiligo using optical coherence tomography (OCT). Read More

    Comorbidities in vitiligo: comprehensive review.
    Int J Dermatol 2018 May 28. Epub 2018 May 28.
    Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.
    Vitiligo is a common skin disorder characterized by idiopathic, progressive cutaneous hypomelanosis. Vitiligo is associated with several comorbid autoimmune, systemic, and dermatological diseases, primarily thyroid disease, alopecia areata, diabetes mellitus, pernicious anemia, systemic lupus erythematosus, rheumatoid arthritis, Addison's disease, inflammatory bowel disease, Sjögren's syndrome, dermatomyositis, scleroderma, ocular and audiological abnormalities, psoriasis, and atopic dermatitis. It is essential to increase awareness of these comorbidities in order to improve the disease burden and quality of life of patients with vitiligo. Read More

    Antipsoriatic effect of fatty acid enriched fraction of Vernonia anthelmintica Willd. fruits.
    J Ethnopharmacol 2018 May 26;224:85-90. Epub 2018 May 26.
    Natural Product Chemistry and Process Development Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur 176061, Himachal Pradesh, India. Electronic address:
    Ethnopharmacological Relevance: Vernonia anthelmintica has been utilized conventionally as an ingredient in Ayurveda and traditional Uighur medicine for management of various skin ailments, and scientific data's have substantiated its use in treating vitiligo, dermatosis and leucoderma. The present investigation was focused to evaluate the antipsoriatic activity of V. anthelmintica fruit extracts and fractions. Read More

    Cutaneous toxicities of new treatments for melanoma.
    Clin Transl Oncol 2018 May 24. Epub 2018 May 24.
    Melanoma Unit, Dermatology Department, Hospital Clinic, Institut d'investigacions biomèdiques August Pi i Sunyer (IDIBAPS), CIBERER, Universitat de Barcelona, Barcelona, Spain.
    New drugs against advanced melanoma have emerged during last decade. Target therapy and immunotherapy have changed the management of patients with metastatic disease. Along with its generalized use, drug toxicities have appeared and the skin is the target organ of a significant part of them. Read More

    Syringes versus Chinese cups in harvesting suction-induced blister graft: a randomized split-body study.
    Int J Dermatol 2018 May 24. Epub 2018 May 24.
    Department of Dermatology, STD's and Andrology, Matay Central Hospital, Minia, Egypt.
    Background: Suction blister grafting (SBG) is a technique where the pigmented epidermis is harvested from the donor site by induction of a blister using different suction methods as syringes, Chinese cups, suction device, etc. However, pain, time consumption, incomplete blister formation, and failure of blister development are the main limitations.

    Objective: To compare between cups and syringes of similar diameter in inducing suction blisters. Read More

    Willingness to pay for a cure of low-risk melanoma patients in Germany.
    PLoS One 2018 24;13(5):e0197780. Epub 2018 May 24.
    Skin Cancer Center, Department of Dermatology, University Hospital Schleswig-Holstein (UKSH), Campus Kiel, Kiel, Germany.
    Malignant melanoma is potentially life-threatening but in most cases curable if detected early. Willingness to pay (WTP) is a preference-based construct that reflects burden of disease by assessment of the monetary value for a hypothetical cure from disease. Since WTP (directly as total amount of money) has not been assessed so far in patients with low risk melanoma, it was interesting to gain insights in this patient population and then, in a second step, compare it directly with the WTP of their treating dermato-oncologists. Read More

    Clinical and Molecular Aspects of Vitiligo Treatments.
    Int J Mol Sci 2018 May 18;19(5). Epub 2018 May 18.
    Department of Dermatology, Venereology and Leprology, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, India.
    Vitiligo is an asymptomatic but cosmetically disfiguring disorder that results in the formation of depigmented patches on skin and/or mucosae. Vitiligo can be segmental or non-segmental depending upon the morphology of the clinical involvement. It can also be classified as progressing or stable based on the activity of the disease. Read More

    Clindamycin-induced Maculopapular Exanthema with Preferential Involvement of Striae Distensae: A Koebner phenomenon?
    Acta Dermatovenerol Croat 2018 Apr;26(1):61-63
    Benigno Monteagudo-Sánchez, MD, Hospital Arquitecto Marcide, Avenida Residencia SN , 15405 Ferrol (A Coruńa), A Coruńa, Spain;
    Clindamycin is a lincomycin-derived antibiotic useful for the treatment of anaerobic and Gram-positive aerobic bacterial infections. Cutaneous adverse reactions are usually maculopapular exanthemas, although hypersensitivity syndrome, acute generalized exanthematous pustulosis, and Stevens-Johnson syndrome have also been reported (1). We report the case of a patient with a maculopapular rash triggered by clindamycin who developed cutaneous lesions on striae distensae (SD). Read More

    The effect of topical piperine combined with narrowband UVB on vitiligo treatment: A clinical trial study.
    Phytother Res 2018 May 21. Epub 2018 May 21.
    Department of Biostatistics, Shahid Beheshti University of Medical Sciences, Tehran, 1971653313, Iran.
    Vitiligo is the most common acquired hypopigmentary disease in the community. Piperine as an herbal extract derived from black pepper has strong impact on the melanocyte proliferation and adverse side effects less than synthetic drugs such as corticosteroids. For the first time, this study was aimed to evaluate the effect of topical piperine combined with narrowband ultraviolet B (NB-UVB) on vitiligo treatment. Read More

    Mindfulness-Based Cognitive Hypnotherapy and Skin Disorders.
    Am J Clin Hypn 2018 Jul;61(1):34-44
    a University of South Florida , Tampa , FL, USA.
    Mindfulness-based cognitive hypnotherapy integrates mindfulness, cognitive-behavioral therapy, and hypnotherapy to improve physical, emotional, mental, and/or spiritual aspects of skin disorders. Meditation, including mindfulness meditation, and hypnosis both utilize trance phenomena to help produce focalization and specific improvements in skin disorders through psycho-neuro-endocrine-immunologic mechanisms. Hypnosis, cognitive hypnotherapy, focused meditation, and mindfulness meditation are discussed with respect to improving various skin disorders including acne, acne excoriée, alopecia areata, atopic dermatitis, congenital ichthyosiform erythroderma, dyshidrotic dermatitis, erythema nodosum, erythromelalgia, furuncles, glossodynia, herpes simplex, hyperhidrosis, ichthyosis vulgaris, lichen planus, neurodermatitis, nummular dermatitis, postherpetic neuralgia, prurigo nodularis, pruritus, psoriasis, rosacea, trichotillomania, urticaria, verruca vulgaris, and vitiligo. Read More

    Therapeutic interventions to lessen the psychosocial effect of vitiligo in children: A review.
    Pediatr Dermatol 2018 May 16. Epub 2018 May 16.
    Division of Dermatology, Dell Medical School, University of Texas, Austin, TX, USA.
    Vitiligo commonly affects children, with half of affected individuals experiencing disease onset before the age of 20. Because childhood is a time of advancement in social and psychological development, understanding the extent of the effect of the disease and means of alleviation is crucial. Vitiligo has been shown to decrease children's quality of life, with greater distress in children with highly visible lesions and darker skin tones. Read More

    Prevalence and comorbidities associated with hidradenitis suppurativa in Korea: a nationwide population-based study.
    J Eur Acad Dermatol Venereol 2018 May 15. Epub 2018 May 15.
    Department of Dermatology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.
    Background: The prevalence of hidradenitis suppurativa (HS) in Asia is unknown. The associations between HS and other autoimmune disorders have rarely been reported.

    Objective: We sought to determine the prevalence of and diseases associated with HS using the National Health Insurance (NHI) database. Read More

    Imbalance of Peripheral Blood T Helper Type 17 Responses in Patients with Vitiligo.
    Iran J Allergy Asthma Immunol 2018 Apr;17(2):171-178
    Department of Dermatology, Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran AND Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
    There is growing evidence to suggest that Th cells play pivotal roles in a variety of chronic inflammatory diseases, including vitiligo. However, the exact role of different subsets of Th cells in the pathogenesis of vitiligo is still a question. The purpose of present study was to determine the mRNA expression level of Th17 master transcription factor retinoic acid receptor-related orphan receptors gamma (RORɣt) and cytokine mRNA and protein expression profiles of Th17 cells. Read More

    Management of resistant halo nevi.
    J Cosmet Laser Ther 2018 May 9:1-4. Epub 2018 May 9.
    a Department of Dermatology and Venereology, Faculty of Medicine , Minia University , Minia , Egypt.
    Background: Halo nevus (HN) is a rare dermatologic disorder characterized by typical whitish rim surrounding an existing melanocytic nevus resembling halo. It is a cosmetic problem that may be linked to vitiligo, and it is advised to remove these nevi in order to avoid development of vitiligo.

    Objectives: The aim of the present study is to evaluate the cosmetic outcome after nevus removal and leukoderma dermabrasion with epithelial graft followed by narrow-band ultraviolet B (NB-UVB) phototherapy as management of resistant halo nevi and avoidance of development of vitiligo. Read More

    Suction Blister Epidermal Grafting for Vitiligo Involving Angles of Lip: Experience of 112 Patients.
    J Cutan Aesthet Surg 2018 Jan-Mar;11(1):13-19
    Department of Dermatology, Venereology and Leprosy (DVL), Institute of Medical Sciences and SUM Hospital, Siksha 'O'Anusandhan University, Bhubaneswar, Odisha, India.
    Background: Lip vitiligo is usually resistant to medical modalities of treatment, and in all these cases, surgery offers a hope. Suction blister grafting (SBG) has been tried since long for lip vitiligo with high rate of success. There have been no long-term follow-up studies of patients with SBG at a difficult-to-treat site like angles of lip, which prompted us to conduct this study. Read More

    Genital Lichen Sclerosus Et Atrophicus: A Benign Skin Disorder With Malignant Aftermath.
    Urology 2018 Jul 2;117:e7-e8. Epub 2018 May 2.
    Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Electronic address:
    Genital lichen sclerosus et atrophicus (LSA) is an uncommon genital dermatosis. Its resemblance to vitiligo, especially during the earlier stages, leads to delay in its diagnosis. Apart from the common complications such as meatal stenosis, balanoposthitis, phimosis, and painful erections, squamous cell carcinoma is a rare but ominous complication of genital LSA. Read More

    Macrophage migration inhibitory factor as an incriminating agent in vitiligo.
    An Bras Dermatol 2018 Mar;93(2):191-196
    Dermatology, Andrology and STDs department, Faculty of Medicine, Menoufia University, El Menoufia, Egypt.
    Background: Vitiligo is an autoimmune skin disorder in which the loss of melanocytes is mainly attributed to defective autoimmune mechanisms and, lately, there has been more emphasis on autoinflammatory mediators. Among these is the macrophage migration inhibitory factor, which is involved in many autoimmune skin diseases. However, little is known about the contribution of this factor to vitiligo vulgaris. Read More

    Vitiligo patients show significant up-regulation of aryl hydrocarbon receptor transcription factor.
    An Bras Dermatol 2018 Mar;93(2):302-303
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
    IL-22 has been implicated in the pathogenesis of vitiligo. However, the role of aryl hydrocarbon receptor transcription factor that acts as a master regulator of IL-22-producing Th22 cells is not fully understood. The goal of this study was to investigate the expression pattern of aryl hydrocarbon receptor in peripheral blood mononuclear cells of patients with vitiligo and in normal controls. Read More

    A direct link between MITF, innate immunity, and hair graying.
    PLoS Biol 2018 May 3;16(5):e2003648. Epub 2018 May 3.
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
    Melanocyte stem cells (McSCs) and mouse models of hair graying serve as useful systems to uncover mechanisms involved in stem cell self-renewal and the maintenance of regenerating tissues. Interested in assessing genetic variants that influence McSC maintenance, we found previously that heterozygosity for the melanogenesis associated transcription factor, Mitf, exacerbates McSC differentiation and hair graying in mice that are predisposed for this phenotype. Based on transcriptome and molecular analyses of Mitfmi-vga9/+ mice, we report a novel role for MITF in the regulation of systemic innate immune gene expression. Read More

    [A rare case of ocular scarrings in a patient with Vogt-Koyanagi-Harada disease].
    Pan Afr Med J 2017 22;28:313. Epub 2017 Dec 22.
    Université Mohamed V Souissi, Service d'Ophtalmologie A, Hôpital des Spécialités, CHU IBN Sina, Rabat, Maroc.
    We here report the case of a 27-year old patient, followed-up in our Department for treatment of chronic Vogt-Koyanagi-Harada disease ( VKH disease). Fundus examination showed depigmentation of the retinal pigment epithelium and of the choroid, appearing as a pseudotumoral peripapillary lesion. Vogt-Koyanagi-Harada disease is a multisystem disorder, characterized by bilateral granulomatous panuveitis with serous exudative multifocal retinal detachment. Read More

    Combination of fractional carbon dioxide laser with narrow band ultraviolet B to induce repigmentation in stable vitiligo: A comparative study.
    J Cosmet Dermatol 2018 Apr 30. Epub 2018 Apr 30.
    Faculty of Medicine, Pathology Department, Tanta University, Tanta, Egypt.
    Background: Despite the numerous treatment modalities available for vitiligo, responses to treatment are still unsatisfactory. For this reason, new treatment modalities and approaches are needed.

    Objective: To evaluate the efficacy and safety of fractional carbon dioxide (CO ) laser therapy followed by narrow band ultraviolet-B (NB-UVB) phototherapy on stable resistant vitiligo. Read More

    The convergence theory for vitiligo: A reappraisal.
    Exp Dermatol 2018 Apr 28. Epub 2018 Apr 28.
    Departments of Dermatology, and Microbiology and Immunology, Northwestern University Chicago (IL), USA.
    Vitiligo is characterized by progressive loss of skin pigmentation. The search for etiologic factors has led to the biochemical, the neurologic and the autoimmune theory. The convergence theory was then proposed several years ago to incorporate existing theories of vitiligo development into a single overview of vitiligo etiology. Read More

    Risk of skin cancer in people with vitiligo: a systematic review and meta-analysis.
    Br J Dermatol 2018 Apr 28. Epub 2018 Apr 28.
    Centre of Evidence Based Dermatology, University of Nottingham, UK.
    Vitiligo is a chronic disorder causing skin depigmentation with around 1% global prevalence, affecting people of all ages, skin types and genders. Due to the absence of melanin in lesional skin there is a theoretical concern that there might be a higher risk of skin cancer in people with vitiligo. However, some studies have shown that the genetic and autoimmune profiles of vitiligo patients may confer a degree of protection against the development of melanoma and non-melanoma skin cancer (NMSC). Read More

    Elevated total Serum IgE in vitiligo might be protective for other autoimmune diseases.
    Br J Dermatol 2018 Apr 28. Epub 2018 Apr 28.
    Department of Dermatology, Bordeaux University Hospitals, Bordeaux, France.
    Vitiligo is a chronic inflammatory skin depigmenting disorder that is often associated with other autoimmune disease such as thyroiditis. Moreover, there is growing evidence that vitiligo is also associated with atopy, a genetic tendency to develop allergic hypersensitivity reactions, with production of immunoglobulin E (IgE). Indeed, the largest study conducted in the US population found a higher prevalence of atopic diseases in vitiligo. Read More

    The Role of Interleukins in Vitiligo: a Systematic Review.
    J Eur Acad Dermatol Venereol 2018 Apr 28. Epub 2018 Apr 28.
    Programa de Pós-Graduação em Ciências Farmacêuticas da Universidade Federal de Sergipe - UFS, Campus Universitário ''Prof. Aloísio de Campos'', 49100-000, São Cristóvão, SE, Brazil.
    Vitiligo is a disorder of the skin that causes depigmentation and asymptomatic macules whose exact cause is still unclear. Although its etiology is not fully elucidated, the main theory of its pathomechanism is that it is associated with the autoimmune process. There is few summarized information about the role of inflammatory mediators, as interleukins, in vitiligo. Read More

    Molecular targets of phytochemicals for skin inflammation.
    Curr Pharm Des 2018 Apr 25. Epub 2018 Apr 25.
    Major in Biomodulation, Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151-742. Korea.
    Skin is a protective organ and the largest of the human body. Due to its pivotal role in aesthetic appearance, skin health has a significant impact on quality of life. Chronic inflammation of the skin often marks the beginning of various skin diseases. Read More

    A standardized method based on pigmented epidermal models evaluates sensitivity against UV-irradiation.
    ALTEX 2018 Apr 13. Epub 2018 Apr 13.
    Translational Center Regenerative Therapies, Fraunhofer Institute for Silicate Research, Würzburg, Germany.
    To protect the human skin from extensive solar radiation, melanocytes produce melanin and disperse it via melanosomes to keratinocytes in the basal and suprabasal layers of the human epidermis. Moreover, melanocytes are associated with pathological skin conditions such as vitiligo and psoriasis. Thus, an in vitro skin model that comprises a defined cutaneous pigmentation system is highly relevant in cosmetic, pharmaceutical and medical research. Read More

    Melanosome-Targeting Near-Infrared Fluorescent Probe with Large Stokes Shift for in Situ Quantification of Tyrosinase Activity and Assessing Drug Effects on Differently Invasive Melanoma Cells.
    Anal Chem 2018 May 2;90(10):6206-6213. Epub 2018 May 2.
    Key Laboratory of Theoretical and Computational Photochemistry, Ministry of Education, College of Chemistry , Beijing Normal University , Beijing 100875 , China.
    Tyrosinase (TYR) plays a vital role in melanin biosynthesis and is widely regarded as a relatively specific marker for melanocytic lesions which involve vitiligo, malignant cutaneous melanoma, Parkinson's disease (PD), etc. However, the detection of TYR in living cells with fluorescent probes is usually interfered by diverse endogenous reactive oxygen species (ROS) and reactive nitrogen species (RNS). Herein, we synthesized a melanosome-targeting near-infrared (NIR) fluorescent probe (HB-NP) with a large Stokes shift (195 nm), achieving a highly sensitive and selective in situ detection for intracellular TYR, by incorporating a m-hydroxybenzyl moiety that recognizes TYR specifically and the morpholine unit which facilitates the probe accumulating in the melanosome into a salicyladazine skeleton. Read More

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