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    Lupus-like cutaneous reaction following pembrolizumab: an immune-related adverse event associated with anti-PD-1 therapy.
    J Cutan Pathol 2017 Oct 13. Epub 2017 Oct 13.
    Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
    PD-1 (programmed cell death-1) inhibitors, used to treat metastatic melanoma and other malignancies, are associated with development of immune-related adverse events in the skin. Such reactions include morbilliform eruptions, vitiligo, alopecia areata, and bullous pemphigoid. In this report, we describe a patient who developed a lupus-like cutaneous reaction in the setting of pembrolizumab therapy for metastatic melanoma, adding to the spectrum of reactions which may be observed in association with PD-1 inhibitor therapy. Read More

    Vitiligo Skin: Exploring the Dermal Compartment.
    J Invest Dermatol 2017 Oct 9. Epub 2017 Oct 9.
    Cutaneous Physiopathology and Integrated Center of Metabolomics Research. Electronic address:
    There is an increasing interest in the apparently normal skin in vitiligo. Altered expression of the adhesion molecule E-cadherin and persistent deregulated intracellular redox status that promotes the acquisition of a stress-induced senescent phenotype in melanocytes of normally pigmented skin from vitiligo patients have been described. Growing evidence has shown that such cellular and functional alterations are not necessarily restricted to melanocytes but may be extended to other cutaneous cell populations in both lesional and non-lesional areas. Read More

    Association Khellin and 308-nm Excimer lamp in the treatment of severe alopecia areata in a child.
    J Cosmet Laser Ther 2017 Oct 11. Epub 2017 Oct 11.
    a Department of Dermatology , Habib Thameur Hospital , Tunis , Tunisia.
    Alopecia areata (AA) is an autoimmune inflammatory disorder of hair, characterized by non-scarring hair loss. 308-nm Excimer lamp (EL) has been reported as one effective modality in the treatment of AA. Khellin is a furanochromone photosensitizer whose chemical structure is close to psoralens and has previously proven its efficacy in vitiligo in association with UVA. Read More

    Effects of Extremely Low Frequency Electromagnetic Fields on Melanogenesis through p-ERK and p-SAPK/JNK Pathways in Human Melanocytes.
    Int J Mol Sci 2017 Oct 11;18(10). Epub 2017 Oct 11.
    Department of Medical Biotechnology (BK21 Plus team), Dongguk University, Goyang-si 10326, Korea.
    This study evaluated frequency-dependent effects of extremely low frequency electromagnetic fields (ELF-EMFs) on melanogenesis by melanocytes in vitro. Melanocytes were exposed to 2 mT EMFs at 30-75 Hz for 3 days before melanogenesis was examined. Exposure to ELF-EMFs at 50 and 60 Hz induced melanogenic maturation without cell damage, without changing cell proliferation and mitochondrial activity. Read More

    Vitamin D and the Skin: An Update for Dermatologists.
    Am J Clin Dermatol 2017 Oct 9. Epub 2017 Oct 9.
    Department of Dermatology, Hôpital Henri Mondor, 51 Avenue du Maréchal de Lattre de Tassigny, 94010, Créteil, France.
    Vitamin D plays a key role in skeletal and cardiovascular disorders, cancers, central nervous system diseases, reproductive diseases, infections, and autoimmune and dermatological disorders. The two main sources of vitamin D are sun exposure and oral intake, including vitamin D supplementation and dietary intake. Multiple factors are linked to vitamin D status, such as Fitzpatrick skin type, sex, body mass index, physical activity, alcohol intake, and vitamin D receptor polymorphisms. Read More

    Skin Manifestations Associated with Autoimmune Liver Diseases: a Systematic Review.
    Clin Rev Allergy Immunol 2017 Oct 9. Epub 2017 Oct 9.
    Dermatologia Ente Ospedaliero Cantonale, Ospedale Regionale Bellinzona e Valli, Bellinzona, Switzerland.
    Autoimmune liver diseases, which include mainly autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis, and the variant syndromes, are often associated with extrahepatic autoimmune diseases. However, the association with cutaneous diseases is less well described. In the present article, we provide a systematic literature review on skin manifestations linked to each of these four autoimmune liver diseases, excluding skin manifestations of systemic diseases. Read More

    The prevalence of psychological co-morbidity in people with vitiligo: a systematic review and meta-analysis.
    Br J Dermatol 2017 Oct 9. Epub 2017 Oct 9.
    Centre of Evidence Based Dermatology, Division of Rheumatology & Orthopaedics, University of Nottingham, UK.
    Background: Vitiligo is a chronic disorder causing skin depigmentation with global prevalence varying from 0.2 to 1.8%. Read More

    Serum 25-hydroxyvitamin D status in chinese children with vitiligo: a case-control study.
    Clin Pediatr (Phila) 2017 Oct 1:9922817734362. Epub 2017 Oct 1.
    1 Department of Laboratory Medicine, Children's Hospital of Shanxi Province, Tai'yuan, China.
    Background: Vitamin D can play a vital role in autoimmune diseases. Epidemiologic evidence demonstrates vitamin D deficiency excited in adult patients with vitiligo.

    Objectives: To investigate 25-hydroxyvitamin D (25(OH)D) levels in children with vitiligo and explore possible relevant factors. Read More

    [Vitiligo revealing Vogt -Koyanagi-Harada disease].
    Pan Afr Med J 2017 24;27:220. Epub 2017 Jul 24.
    Service de Dermatologie-Vénéréologie, Hôpital Militaire d'Instruction Mohammed V, Rabat, Maroc.
    Vitiligo is a chronic auto-immune skin disease, often associated or discovers other autoimmune pathologies. His association with Ophthalmological type pan uveitis and/or neurological type of meningitis and/or inner ear type of hearing loss determines the disease or Vogt -Koyanagi-Harada syndrome (VKH). We related the case of a young woman who consulted for recurrent uveitis for a year, and it was only with the onset of vitiligo lesions that VKH disease diagnosis was discussed and confirmed. Read More

    Matrix metalloproteinase in acral and non-acral vitiligo.
    Photodermatol Photoimmunol Photomed 2017 Oct 4. Epub 2017 Oct 4.
    Departments of Dermatology, Cairo University, Egypt.
    Repigmentation in vitiligo requires activation, proliferation and migration of the melanoblasts and melanocytes into the depigmented epidermis (1). Cell migration involves modifications of the architecture of cells which requires activation of enzymes that are involved in ECM degradation such as matrix metalloproteinases (MMPs). The significant reduction of their expression in vitiliginous skin has been previously demonstrated (2) and thereby incriminated to share in reducing the migration of melanocytes and their precursors. Read More

    Study of efficacy and safety of noncultured, extracted follicular outer root sheath cell suspension transplantation in the management of stable vitiligo.
    Int J Dermatol 2017 Oct 3. Epub 2017 Oct 3.
    Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
    Background: Noncultured, extracted follicular outer root sheath suspension (NC-EHF-ORS-CS) is a recently introduced technique for the treatment of stable vitiligo.

    Objective: To study the clinical efficacy of this technique and to determine the viability and cell composition of the suspension.

    Methods: Twenty-five patients with stable vitiligo were included in this prospective study. Read More

    Coexistence of eruptive syringoma and bilateral nipple vitiligo: Could there be a common immunopathogenesis?
    North Clin Istanb 2017 26;4(2):195-198. Epub 2017 Aug 26.
    Department of Pathology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
    The rarely seen eruptive syringoma (ES) is characterized by small, skin-colored, papules. Lesions are benign; however, treatment is often unsuccessful. Recent studies have a suggested role of the autoimmune response, rather than reactive proliferation of acrosyringium in the pathogenesis of ES. Read More

    Treatment of Laser Therapy-Induced Punctate Leukoderma Using a 308-nm Excimer Laser.
    Ann Dermatol 2017 Oct 25;29(5):630-632. Epub 2017 Aug 25.
    Department of Dermatology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.
    Punctate leukoderma presents as numerous, distinct, round or oval depigmented spots. Recently, laser therapy-induced punctate leukoderma associated with various Q-switched laser and carbon dioxide laser have been reported. A 25-year-old man presented with numerous, discrete, round, confetti-like, depigmented macules on his left neck. Read More

    Earliest depiction of vitiligo in "Venus at a Mirror" (1615) by Peter Paul Rubens (1577-1640).
    J Cosmet Dermatol 2017 Sep 27. Epub 2017 Sep 27.
    The Department of Surgery and Cancer, Imperial College London, St Mary's Hospital, London, UK.
    The 1615 painting of Venus at a Mirror by Peter Paul Rubens is considered a powerful example of the Flemish Baroque movement. Recently it has been identified that the Venus character in the image has a goitre, however on studying the image further, I note dermato-pathology in another of the painting's main characters; the dark-skinned female typically described as the Venus' maidservant who clearly demonstrates patches of skin pigment loss on her face and neck with a concurrent streak of white hair. Together these suggest the underlying diagnosis of vitiligo. Read More

    Is There a Relation between Vitamin D and Interleukin-17 in Vitiligo? A Cross-Sectional Study.
    Dermatology 2017 Sep 28. Epub 2017 Sep 28.
    Department of Dermatology and Venereology, National Research Centre, Giza, Egypt.
    Background: High interleukin (IL)-17 contributes to vitiligo pathogenesis. Vitamin D has been assessed in vitiligo, with no reports targeting its relation to IL-17.

    Objective: To evaluate a possible regulatory effect of vitamin D on IL-17 and their relation to disease activity in vitiligo. Read More

    Vascular sclerosing effects of bleomycin on cutaneous veins: a pharmacopathologic study on experimental animals.
    An Bras Dermatol 2017 Jul-Aug;92(4):484-491
    Department of Family & Community Medicine, College of Medicine, King Saud University - Riyadh, Saudi Arabia.
    Background:: Varicose veins and the complications of venous disease are common disorders in humans.

    Objective:: To study the effects of bleomycin as a potential new sclerosing agent and its adverse events in treating varicose veins.

    Methods:: Bleomycin-loaded liposomes 0. Read More

    Morphea in Middle Anatolia, Turkey: a 5-year single-center experience.
    Postepy Dermatol Alergol 2017 Aug 1;34(4):334-338. Epub 2017 Aug 1.
    Department of Dermatology and Venereology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey.
    Introduction: Morphea, also referred to as localized scleroderma, is a rare fibrosing skin disorder of undetermined cause.

    Aim: We report our single-center experience with morphea.

    Material And Methods: The study included 53 patients who were diagnosed with morphea by histopathology in our department between 2010 and 2015. Read More

    The welcoming attitude of dermatologists towards complementary and alternative medicine despite their lack of knowledge and training.
    Saudi Pharm J 2017 Sep 26;25(6):838-843. Epub 2016 Dec 26.
    Clinical Pharmacy Department, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
    Background/aim: Although complementary and alternative medicine (CAM) use is highly prevalent, there is very limited information on dermatologists' attitudes and knowledge about CAM. In this survey, we aimed to study the knowledge and attitude of dermatologists in Saudi Arabia towards CAM. Furthermore, we assessed dermatologists' intention to receive CAM education and training. Read More

    [Research development and thinking of clinical study of Polygonum multiflorum].
    Zhongguo Zhong Yao Za Zhi 2017 Jan;42(2):259-263
    Shandong University of Traditional Chinese Medicine, Ji'nan 250355, China.
    In order to offer the accordance and research ideas for further research of effect, indication and ensure the safety and effectiveness of clinical medication, the current states of clinical application and adverse reaction of Polygonum multiflorum were summarized. The related literatures in recent years were collated, analyzed and summed up. P. Read More

    Skin diseases of the male external genitalia in the Tanlangai Hospital in Brazzaville, Congo.
    Med Sante Trop 2017 Aug;27(3):296-300
    CHU Brazzaville, 13 avenue Auxence-IKonga, Brazzaville, Congo.
    To determine the frequency of diseases responsible for skin lesions of the male external genitalia. This descriptive retrospective study examined the medical records of patients older than 14 years treated for genital symptoms as outpatients at the Dermatology Department of Talangaï Hospital in Brazzaville in 2009-2011. Patients' sociodemographic, medical history, clinical, and laboratory data were collected on a standardized individual form. Read More

    Tumour- and class-specific patterns of immune-related adverse events of immune checkpoint inhibitors: a systematic review.
    Ann Oncol 2017 Oct;28(10):2377-2385
    Drug Development Program, Division of Medical Oncology and Haematology, Princess Margaret Cancer Centre, Toronto.
    Background: Immune checkpoint inhibitor (ICI) monoclonal antibodies (mAbs) targeting cytotoxic T-lymphocyte antigen 4 (CTLA-4), programmed cell death protein 1 (PD-1) or its ligand (PD-L1) produce unique toxicity profiles. The objective of this review was to identify patterns and incidence of immune-related adverse events (irAE) based on tumour type and ICI class.

    Methods: Medline, EMBASE and COCHRANE databases were searched to identify prospective monotherapy trials of ICIs from 2003 to November 2015. Read More

    Replenishing Regulatory T Cells to Halt Depigmentation in Vitiligo.
    J Investig Dermatol Symp Proc 2017 Oct;18(2):S38-S45
    Department of Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
    Vitiligo is a cutaneous autoimmune disease, especially devastating to patients with darker skin tones because of the contrast between unaffected and lesional skin. We studied immune cells infiltrating vitiligo skin and found very few regulatory T cells (Tregs). Vitiligo was not associated with a reduced frequency or function of circulating Tregs. Read More

    Vitiligo Surgery: Shuffling Melanocytes.
    J Investig Dermatol Symp Proc 2017 Oct;18(2):S34-S37
    Department of Dermatology, Henry Ford Hospital, Detroit, Michigan, USA. Electronic address:
    Vitiligo is a disorder characterized by the development of depigmented macules and patches secondary to melanocyte destruction. Several treatment options are available, including medical, light-based, and surgical therapies, that are often used in combination to achieve maximal repigmentation. Vitiligo surgery is an effective yet underperformed treatment, mainly because of lack of awareness and availability. Read More

    From Bench to Bedside: The Hampton University Skin of Color Research Institute 2015 Skin of Color Symposium.
    J Investig Dermatol Symp Proc 2017 Oct;18(2):S29-S30
    Department of Dermatology, Eastern Virginia Medical School, Norfolk, Virginia, USA; Hampton University Skin of Color Research Institute, Hampton, Virginia, USA. Electronic address:
    The Hampton University Skin of Color Research Institute Skin of Color Symposium 2015: From Bench to Bedside was held in Williamsburg, Virginia at the Williamsburg Lodge, November 13-15, 2015. The conference was designed to promote, develop, and advance the education, knowledge, and research of cutaneous disorders disproportionately affecting people of racial and ethnic minority groups. Centered on the theme of "From Bench to Bedside", the symposium provided a program featuring a diverse panel of nationally recognized physician-scientists, basic scientists, and clinicians who updated attendees on the latest research advances across multiple relevant disciplines, including public health, basic science, and the clinical diagnosis and management of select complex and rare dermatologic conditions. Read More

    The patterns of birthmarks suggest a novel population of melanocyte precursors arising around the time of gastrulation.
    Pigment Cell Melanoma Res 2017 Sep 23. Epub 2017 Sep 23.
    Institut Curie, INSERM U1021, Normal and Pathological Development of Melanocytes, PSL Research University, Orsay, France.
    Systematic work in the mouse and chicken has mapped out two neural crest-derived pathways of melanocyte precursor migration. With these in mind, this study reappraises the patterns of congenital pigmentary disorders in humans and identifies three recurrent patterns consistent across genetically different diseases. Only two of these are seen in diseases known to be melanocyte cell-autonomous. Read More

    Comprehensive survey of vitiligo patients in the northeast of China using a predesigned questionnaire.
    J Dermatol 2017 Sep 22. Epub 2017 Sep 22.
    Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang, China.
    To assess the sociodemographic data and clinical information of outpatients affected by vitiligo in the northeast of China, vitiligo patients or guardians who presented to the clinic were invited to participate in an exploratory questionnaire. The questionnaire consisted of two sections related to vitiligo, including sociodemographic data and clinical information. A total of 983 vitiligo patients answered the questionnaire. Read More

    Vitiligo skin is imprinted with resident memory CD8 T cells expressing CXCR3.
    J Invest Dermatol 2017 Sep 16. Epub 2017 Sep 16.
    INSERM U1035, BMGIC, Immuno-dermatology ATIP-AVENIR, University of Bordeaux; Department of Dermatology and Pediatric Dermatology; National Reference Center for Rare Skin disorders, Hôpital Saint-André, Bordeaux, France.
    Vitiligo is a chronic auto-immune depigmenting skin disorder that results from a loss of melanocytes. Multiple combinatorial factors have been involved in disease development, with a prominent role of the immune system, in particular T cells. After repigmentation, vitiligo frequently recurs in the same area, suggesting that vitiligo could involve the presence of resident memory T cells (TRM). Read More

    Autoimmune diseases involving skin and intestinal mucosa are more frequent in adolescents and young adults suffering from atopic dermatitis.
    J Dermatol 2017 Sep 19. Epub 2017 Sep 19.
    Pediatric Unit, Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
    Evidence has emerged about the relationship between atopic dermatitis (AD) and autoimmune diseases, but the underlying mechanism of this association is complex and still unclear. Recent epidemiological data from the published work suggest a positive correlation. The aim of this review is to analyze the frequency of co-occurrence of AD and autoimmune diseases. Read More

    Psoriasis and vitiligo are close relatives.
    Clin Cosmet Investig Dermatol 2017 29;10:341-345. Epub 2017 Aug 29.
    Department of Dermatology and Venereology, Baghdad Teaching Hospital, Baghdad, Iraq.
    Background: Both vitiligo and psoriasis are chronic inflammatory autoimmune diseases with genetic elements.

    Objective: To estimate the frequencies of psoriasis in vitiligo patients and vice versa and to compare them with healthy controls.

    Patients And Methods: A total of 1000 subjects were included, 250 of them had vitiligo, 250 had psoriasis, and 500 were healthy controls. Read More

    Pigmentary changes in patients treated with targeted anticancer agents: A systematic review and meta-analysis.
    J Am Acad Dermatol 2017 Nov 14;77(5):902-910.e2. Epub 2017 Sep 14.
    Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address:
    Background: The discovery of signaling networks that drive oncogenic processes has led to the development of targeted anticancer agents. The burden of pigmentary adverse events from these drugs is unknown.

    Objective: To conduct a systematic review and meta-analysis of published clinical trials and determine the incidence and risk of development of targeted therapy-induced pigmentary changes. Read More

    Phototherapy for vitiligo, what's new?
    G Ital Dermatol Venereol 2017 Oct;152(5):474-488
    San Gallicano Dermatological Institute, IRCCS, Rome, Italy -
    Vitiligo is a disorder characterized by the development of depigmented macules and patches. Existing treatments include topical and systemic immunosuppressants, topical vitamin D analogues in monotherapy or in association with phototherapy, phototherapy and surgical techniques, which together may serve to halt disease progression, stabilize depigmented lesions, and encourage repigmentation. Narrow-band UVB (NB-UVB 310-315 nm) radiation is now considered as the "gold standard" for the treatment of diffuse vitiligo. Read More

    The Use of Adipose-Derived Stem Cells in Selected Skin Diseases (Vitiligo, Alopecia, and Nonhealing Wounds).
    Stem Cells Int 2017 21;2017:4740709. Epub 2017 Aug 21.
    Foundation for Nerve Cell Regeneration, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
    The promising results derived from the use of adipose-derived stem cells (ADSCs) in many diseases are a subject of observation in preclinical studies. ADSCs seem to be the ideal cell population for the use in regenerative medicine due to their easy isolation, nonimmunogenic properties, multipotential nature, possibilities for differentiation into various cell lines, and potential for angiogenesis. This article reviews the current data on the use of ADSCs in the treatment of vitiligo, various types of hair loss, and the healing of chronic wounds. Read More

    No Association Between Vitiligo and Obesity: A Case-control Study.
    Med Princ Pract 2017 Sep 12. Epub 2017 Sep 12.
    Objective: The purpose of this study was to investigate the relationship between vitiligo and body mass index to assess the possible association between vitiligo and obesity.

    Subjects And Methods: This was a case-control study on a total of 400 participants: 200 patients with vitiligo and 200 healthy volunteers. Medical assessments were performed by dermatologists using the modified Vitiligo European Task Force form. Read More

    Serum Thyroid Hormone Antibodies Are Frequent in Patients with Polyglandular Autoimmune Syndrome Type 3, Particularly in Those Who Require Thyroxine Treatment.
    Front Endocrinol (Lausanne) 2017 28;8:212. Epub 2017 Aug 28.
    Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
    Polyglandular autoimmune syndrome (PAS) type 3 consists of autoimmune thyroid disease (AITD) coexisting with ≥1 non-thyroidal autoimmune disease (NTAID) other than Addison's disease and hypoparathyroidism. We evaluated the prevalence and repertoire of thyroid hormones antibodies (THAb) in PAS-3 patients. Using a radioimmunoprecipation technique, we measured THAb (T3IgM, T3IgG, T4IgM, and T4IgG) in 107 PAS-3 patients and 88 controls (patients with AITD without any NTAID). Read More

    Shedding Light on Alopecia Areata in Pediatrics: A Retrospective Analysis of Comorbidities in Children in the National Alopecia Areata Registry.
    Pediatr Dermatol 2017 Sep;34(5):e271-e272
    Department of Dermatology, Columbia University, New York, New York.
    Alopecia areata (AA) is a common autoimmune disease and it is challenging to predict which patients will have severe disease. The purpose of this retrospective study was to identify comorbidities in children enrolled in the National Alopecia Areata Registry. Atopic dermatitis was more common in patients with severe AA than in those with mild disease. Read More

    Insight into Natural History of Congenital Vitiligo: A Case Report of a 23-Year-Old with Stable Congenital Vitiligo.
    Case Rep Dermatol Med 2017 14;2017:5172140. Epub 2017 Aug 14.
    Department of Internal Medicine, University of North Texas Health Science Center, Texas College of Osteopathic Medicine, Fort Worth, TX, USA.
    Vitiligo is a disorder of skin pigmentation. It affects approximately 1% of the world's population. Vitiligo occurs equally between the sexes with no racial predilections. Read More

    Protective effect of madecassoside on H2O2-induced oxidative stress and autophagy activation in human melanocytes.
    Oncotarget 2017 Aug 7;8(31):51066-51075. Epub 2017 May 7.
    Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, 210029, P.R. China.
    Background: Centella asiatica (L.) Urb. is a traditional Chinese medicine that has many medical applications, including wound healing and anti-oxidation. Read More

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