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    1 OF 125

    CD49a Expression Defines Tissue-Resident CD8(+) T Cells Poised for Cytotoxic Function in Human Skin.
    Immunity 2017 Feb 13. Epub 2017 Feb 13.
    Department of Medicine Solna, Karolinska Institutet, Stockholm 171 77, Sweden; Dermatology Department, Karolinska University Hospital, Stockholm 141 86, Sweden. Electronic address:
    Tissue-resident memory T (Trm) cells form a heterogeneous population that provides localized protection against pathogens. Here, we identify CD49a as a marker that differentiates CD8(+) Trm cells on a compartmental and functional basis. In human skin epithelia, CD8(+)CD49a(+) Trm cells produced interferon-γ, whereas CD8(+)CD49a(-) Trm cells produced interleukin-17 (IL-17). Read More

    Reduced immunohistochemical expression of adhesion molecules in vitiligo skin biopsies.
    Pathol Res Pract 2016 Dec 30. Epub 2016 Dec 30.
    Experimental Pathology Laboratory, School of Medicine, Pontifical Catholic University of Paraná, Rua Imaculada Conceição, 1155 - Prado Velho, Curitiba, PR, CEP 80215-901, Brazil.
    Because defects in adhesion impairment seem to be involved in the etiopathogenesis of vitiligo, this study aimed to compare the immunohistochemical expression of several adhesion molecules in the epidermis of vitiligo and non lesional vitiligo skin. Sixty-six specimens of lesional and non lesional skin from 33 volunteers with vitiligo were evaluated by immunohistochemistry using anti-beta-catenin, anti-E-cadherin, anti-laminin, anti-beta1 integrin, anti-collagen IV, anti-ICAM-1 and anti-VCAM-1 antibodies. Biopsies of vitiligo skin demonstrated a significant reduction in the expression of laminin and integrin. Read More

    Pigmentation traits, sun exposure, and risk of incident vitiligo in women.
    J Invest Dermatol 2017 Feb 14. Epub 2017 Feb 14.
    Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA; Department of Epidemiology, Brown University School of Public Health, Providence, RI 02903, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. Electronic address:
    Vitiligo is the most common cutaneous depigmentation disorder worldwide, yet little is known about specific risk factors for disease development. Utilizing data from the Nurses' Health Study (NHS), a prospective cohort study of 51,337 white women, we examined the associations between (1) pigmentary traits and (2) reactions to sun exposure and risk of incident vitiligo. NHS participants responded to a question about clinician-diagnosed vitiligo and year of diagnosis (2001 or before, 2002-2005, 2006-2009, 2010-2011, or 2012+). Read More

    S100B is a potential disease activity marker in non-segmental vitiligo.
    J Invest Dermatol 2017 Feb 14. Epub 2017 Feb 14.
    Department of Dermatology, Ghent University Hospital, Ghent, Belgium.
    Vitiligo is a chronic skin condition characterized by progressive depigmentation of the skin. S100B is a damage-associated molecular pattern (DAMP) protein expressed in melanocytes, which has been proposed as a marker of melanocyte cytotoxicity. While the use of S100B as a biomarker in melanoma is well established, its association with vitiligo activity has not yet been investigated. Read More

    Dermatoglyphics in Vitiligo.
    Indian J Dermatol Venereol Leprol 1981 Mar-Apr;47(2):102-104
    A Total of 80 cases, comprising of 40 controls and 40 vitiligo cases, were studied for, dermatoglyphic pattern and ridge count. In males with vitiligo increased incidence of radial loops of 2nd fingers and increased incidence of arches were observed while in females, increased incidence of ulnar loops on 3rd digit was observed in the present study. Difference in patterns in cases of vitiligo as compared to normal, was statistically insignificant. Read More

    Clinical Evaluation of Clofazimine in Vitiligo.
    Indian J Dermatol Venereol Leprol 1981 Jan-Feb;47(1):40-41
    In a purely clinical unbiased study, fifty patients' with multifocal extensive, vitiligo were given oral clofazimine therapy for six months and another fifty patients were kept as controls. All the patients were exposed to sunrays for thirty minutes daily. Significantly more patients in the treated group developed pigmentation of the patches compared to the, control group. Read More

    Influence of Pregnancy on Vitiligo Activity.
    J Clin Aesthet Dermatol 2016 Dec 1;9(12):21-25. Epub 2016 Dec 1.
    Department of Dermatology, Loyola University, Stritch School of Medicine, Maywood, Illinois.
    Background: Vitiligo vulgaris, an acquired disease related to autoimmune activity directed against melanocytes, is a common disorder of pigmentation affecting up to one percent of the population. Several autoimmune disorders are reported to improve during pregnancy-a state of relative immunosuppression. Objectives: To assess self-reported changes in vitiligo disease activity that occurred during pregnancy. Read More

    Advances in Vitiligo: An Update on Medical and Surgical Treatments.
    J Clin Aesthet Dermatol 2017 Jan 1;10(1):15-28. Epub 2017 Jan 1.
    The Ronald O. Perelman Department of Dermatology, New York University, New York, New York.
    Vitiligo is one of the most common cutaneous disorders of depigmentation. Although its underlying causes are still being studied and no definitive cure currently exists, recent research has provided insight into pathogenic mechanisms and new treatment options. Objective: The aim of this paper is to provide a comprehensive overview of the medical and surgical therapies for vitiligo with emphasis on the most recent treatment modalities. Read More

    Aquaporin 3 and E-Cadherin Expression in Perilesional Vitiligo Skin.
    J Clin Diagn Res 2016 Dec 1;10(12):WC01-WC06. Epub 2016 Dec 1.
    Assistant Lecturer, Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufiya University , Egypt .
    Introduction: Vitiligo is a common dermatologic disorder with debated aetiology. Most studies focused on role of melanocytes and few investigated the role of keratinocytes in pathogenesis of the disease.

    Aim: To investigate the keratinocyte adhesion in perilesional vitiligo skin through the immunolocalization of Aquaporin-3 (AQP3) and E-cadherin. Read More

    Association and expression of antigen processing gene PSMB8 coding for Low Molecular Mass Protease 7 (LMP7) with Vitiligo in North India: case-control study.
    Br J Dermatol 2017 Feb 16. Epub 2017 Feb 16.
    Molecular Immunogenetics Group, National Institute of Immunology, New Delhi, 110067, India.
    Background: Vitiligo is a multifactorial, autoimmune, depigmenting disorder of the skin where aberrant presentation of auto antigens may have a role to play.

    Objectives: To study the association of antigen processing genes, PSMB8 and PSMB9 with vitiligo.

    Methods: 1320 vitiligo cases (1050 generalized and 270 localized) and 752 normal healthy controls were studied for PSMB9 exon 3 G/A SNP, PSMB8 exon 2 C/A SNP and PSMB8 Intron 6 G/T at 37360 site using PCR-RFLP. Read More

    Vitiligo susceptibility and catalase gene (CAT) polymorphisms in sicilian population.
    G Ital Dermatol Venereol 2017 Feb 15. Epub 2017 Feb 15.
    Department of Dermatology, University of Palermo, Palermo, Italy.
    Background: Catalase gene (CAT) polymorphisms were analyzed as responsible for the deficiency of catalase enzyme activity and concomitant accumulation of excessive hydrogen peroxide in Vitiligo patients. Catalase is a well known oxidative stress regulator that could play an important role in the pathogenesis of Vitiligo. This study was conducted to evaluate three CAT gene polymorphisms (-89A/T, 389C/T, 419C/T) and their association with Vitiligo susceptibility in Sicilian population. Read More

    Hearing loss in vitiligo: current concepts and review.
    Eur Arch Otorhinolaryngol 2017 Feb 14. Epub 2017 Feb 14.
    Department of Otolaryngology/Head and Neck Surgery, Hadassah School of Medicine, Hadassah-Hebrew University Medical Center, 91120, Jerusalem, Israel.
    The objective of this study was to describe the occurrence, clinical manifestations, audiometric findings, pathogenesis and approach to sensorineural hearing loss (SNHL) among patients diagnosed with vitiligo with a review of the literature. We present a systematic review of the literature on cases of SNHL in patients diagnosed with vitiligo and studies conducted to investigate audiometric changes in such patients. Data on presentation, diagnosis and medical approach were reviewed. Read More

    Treatment of Infantile Inflammatory Bowel Disease and Autoimmunity by Allogeneic Stem Cell Transplantation in LPS-Responsive Beige-Like Anchor Deficiency.
    Front Immunol 2017 31;8:52. Epub 2017 Jan 31.
    Division for Pediatric Stem-Cell Transplantation and Immunology, University Hospital Frankfurt , Frankfurt/Main , Germany.
    Inflammatory bowel disease (IBD) in young children can be a clinical manifestation of various primary immunodeficiency syndromes. Poor clinical outcome is associated with poor quality of life and high morbidity from the complications of prolonged immunosuppressive treatment and malabsorption. In 2012, mutations in the lipopolysaccharide-responsive beige-like anchor (LRBA) gene were identified as the cause of an autoimmunity and immunodeficiency syndrome. Read More

    Acquired Hair Curling after Diphenylcyclopropenone Immunotherapy in Alopecia Areata Patient.
    J Eur Acad Dermatol Venereol 2017 Feb 13. Epub 2017 Feb 13.
    Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
    Contact immunotherapy using diphenylcyclopropenone (DPCP) is commonly used treatment modality for moderate to severe alopecia areata (AA)(1) . The most common side effects associated with topical immunotherapy using DPCP include eczema, hyperpigmentation, hypopigmentation, vitiligo, and cicatricial alopecia. However, we identified an interesting case of a patient whose entire scalp of straight hair (Figure 1A) became curly after DPCP immunotherapy, which has not been reported previously. Read More

    Cutaneous adverse effects of the immune checkpoint inhibitors.
    Curr Probl Cancer 2016 Dec 14. Epub 2016 Dec 14.
    Section of Dermatology, Department of Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire; Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire.
    The immune checkpoint targeted agents, anti-cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and anti-programed cell death 1 (PD-1) or anti-programmed death ligand 1 (PD-L1) inhibitors are frequently associated with cutaneous side effects that are often dose limiting and can lead to discontinuation of therapy. Ipilimumab, a CTLA-4 inhibitor, is most commonly associated with a morbilliform eruption on the trunk and extremities and pruritus. More severe cutaneous toxicities reported include toxic epidermal necrolysis and severe drug rash with eosinophila and systemic symptoms. Read More

    Dysregulated autophagy increased melanocyte sensitivity to H2O2-induced oxidative stress in vitiligo.
    Sci Rep 2017 Feb 10;7:42394. Epub 2017 Feb 10.
    Department of Dermatology, Xijing hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
    In vitiligo, melanocytes are particularly vulnerable to oxidative stress owing to the pro-oxidant state generated during melanin synthesis and to the genetic antioxidant defects. Autophagy is a controlled self-digestion process which can protect cells against oxidative damage. However, the exact role of autophagy in vitiligo melanocytes in response to oxidative stress and the mechanism involved are still not clear. Read More

    Simvastatin protects human melanocytes from H2O2-induced oxidative stress by activating Nrf2.
    J Invest Dermatol 2017 Feb 4. Epub 2017 Feb 4.
    Department of Dermatology, Xijing hospital, Fourth Military Medical University, Xi'an, Shaanxi, China. Electronic address:
    The prevention of hydrogen peroxide (H2O2)-induced oxidative stress has been proved to be beneficial to vitiligo patients. Simvastatin possesses anti-oxidative capacity and has shown protective effect in various oxidative stress-related diseases. However, whether simvastatin can protect human melanocytes against oxidative stress has not been investigated. Read More

    Janus kinase inhibitors in dermatology: A systematic review.
    J Am Acad Dermatol 2017 Feb 3. Epub 2017 Feb 3.
    Department of Dermatology, Hadassah - Hebrew University Medical Center, Jerusalem, Israel. Electronic address:
    Background: Janus kinase (JAK) inhibitors are emerging as a promising new treatment modality for many inflammatory conditions.

    Objective: Our aim was to systematically review the available data on the use of JAK inhibitors in cutaneous diseases.

    Methods: This is a systematic review of PubMed and ClinicalTrials. Read More

    Association of protein tyrosine phosphatase, non-receptor type 22 +1858C→T polymorphism and susceptibility to vitiligo: Systematic review and meta-analysis.
    Indian J Dermatol Venereol Leprol 2017 Mar-Apr;83(2):183-189
    Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Solan, Himachal Pradesh, India.
    Background: Protein tyrosine phosphatase, non-receptor type 22 gene, which translates to lymphoid tyrosine phosphatase, is considered to be a susceptibility gene marker associated with several autoimmune diseases. Several studies have demonstrated the association of protein tyrosine phosphatase, non-receptor type 22 +1858C→T polymorphism with vitiligo. However, these studies showed conflicting results. Read More

    Skin depigmentation associated with toceranib phosphate in a dog.
    Vet Dermatol 2017 Feb 6. Epub 2017 Feb 6.
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, 220 Trowbridge Road, East Lansing, MI, 48824, USA.
    Background: Drug-induced depigmentation is frequently observed in humans undergoing tyrosine kinase inhibitor therapy, whereas it is not reported in dogs. The skin depigmentation can occur after the first week of treatment and it is reversible within a few weeks after drug discontinuation.

    Objectives: To report the clinical and histopathological features of an episode of cutaneous adverse drug reaction associated with short term administration of toceranib phosphate. Read More

    Reduction of Blister Formation Time in Suction Blister Epidermal Grafting in Vitiligo Patients Using a Household Hair Dryer.
    J Cutan Aesthet Surg 2016 Oct-Dec;9(4):232-235
    Department of Skin and VD, IMS and SUM Hospital, S 'O' A University, Bhubaneswar, Odisha, India.
    Background: Suction blister epidermal grafting (SBEG) is a simple and effective way of surgical repigmentation in vitiligo. The major problem faced is the time taken for the formation of blisters. Temperature at the suction site is one of the factors affecting the blister formation time. Read More

    Light-stick: A problem of marine pollution in Brazil.
    Mar Pollut Bull 2017 Jan 31. Epub 2017 Jan 31.
    Laboratório de Ecotoxicologia, Centro Universitário Monte Serrat, Av. Rangel Pestana, 99, Vila Mathias, 11013-931 Santos, SP, Brazil.
    Light-sticks are used as bait in surface long-line fishing, to capture swordfish and other large pelagic predators. When discharged in the ocean, it may reach the beaches. The traditional Brazilian community of Costa dos Coqueiros, Bahia, use light-sticks as a medicine for rheumatism, vitiligo and mycoses. Read More

    Effect of Procedural-Related Variables on Melanocyte-Keratinocyte Suspension Transplantation in Nonsegmental Stable Vitiligo: A Clinical and Immunocytochemical Study.
    Dermatol Surg 2017 Feb;43(2):226-235
    Departments of *Dermatology, †Histology, and ‡Clinical Pathology, Kasr El-Ainy Teaching Hospital, Faculty of Medicine, Cairo University, Cario, Egypt.
    Background: Melanocyte-keratinocyte suspension (M-K susp) is gaining popularity for vitiligo treatment. Few studies have addressed procedure-related variables.

    Objective: To assess the effect of different M-K susp procedure-related variables on the clinical outcome in stable vitiligo. Read More

    Ultrathin Skin Grafting in Resistant Stable Vitiligo: A Follow-up Study of 8 Years in 370 Patients.
    Dermatol Surg 2017 Feb;43(2):218-225
    *All authors are affiliated with the CUTIS Institute of Dermatology, Srinagar, India.
    Background: Ultrathin skin grafting (UTSG) is a tissue grafting technique used in resistant stable vitiligo.

    Objective: To assess long-term follow-up results achieved with UTSG in vitiligo.

    Methods: Over a span of 8 years, a total of 415 patients with stable vitiligo were treated with UTSG at the authors' institute. Read More

    Large Intragenic Deletion in DSTYK Underlies Autosomal-Recessive Complicated Spastic Paraparesis, SPG23.
    Am J Hum Genet 2017 Feb;100(2):364-370
    St John's Institute of Dermatology, King's College London (Guy's Campus), London SE1 9RT, UK; Centre for Dermatology and Genetic Medicine, Division of Molecular Medicine, University of Dundee, Dundee DD1 5EH, UK. Electronic address:
    SPG23 is an autosomal-recessive neurodegenerative subtype of lower limb spastic paraparesis with additional diffuse skin and hair dyspigmentation at birth followed by further patchy pigment loss during childhood. Previously, genome-wide linkage in an Arab-Israeli pedigree mapped the gene to an approximately 25 cM locus on chromosome 1q24-q32. By using whole-exome sequencing in a further Palestinian-Jordanian SPG23 pedigree, we identified a complex homozygous 4-kb deletion/20-bp insertion in DSTYK (dual serine-threonine and tyrosine protein kinase) in all four affected family members. Read More

    JAK inhibitors in dermatology: The promise of a new drug class.
    J Am Acad Dermatol 2017 Jan 28. Epub 2017 Jan 28.
    Department of Dermatology, Yale School of Medicine, New Haven, Connecticut. Electronic address:
    New molecularly targeted therapeutics are changing dermatologic therapy. Janus kinase-signal transducer and activator of transcription (JAK-STAT) is an intracellular signaling pathway upon which many different proinflammatory signaling pathways converge. Numerous inflammatory dermatoses are driven by soluble inflammatory mediators, which rely on JAK-STAT signaling, and inhibition of this pathway using JAK inhibitors might be a useful therapeutic strategy for these diseases. Read More

    Use of Phototherapy in Children.
    Pediatr Dermatol 2017 Jan 30. Epub 2017 Jan 30.
    Department of Dermatology, Alder Hey Children's Hospital, Liverpool, UK.
    Background: Phototherapy is a well-recognized treatment in adults and children. Previous articles have reported success in treating recalcitrant skin disorders such as atopic dermatitis (AD), psoriasis, pityriasis lichenoides chronica, and vitiligo in children.

    Methods: This was a retrospective review over an 18-month period from June 2012 to December 2013 of all children receiving phototherapy in a tertiary pediatric dermatology center. Read More

    Misbalanced CXCL12 and CCL5 chemotactic signals in vitiligo onset and progression.
    J Invest Dermatol 2017 Jan 26. Epub 2017 Jan 26.
    Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, Thomas Jefferson University, 233 S. 10(th) Street, Philadelphia, PA 19107, USA. Electronic address:
    Generalized non-segmental vitiligo is often associated with the activation of the melanocyte-specific autoimmunity. As chemokines play an important role in maintenance of immune responses, we examined chemotactic signatures in cultured vitiligo melanocytes and skin samples of early (≤ 2 months) and advanced (≥ 6 months) vitiligo. Analysis revealed that melanocytes in early lesions have altered expression of several chemotaxis-associated molecules, including elevated secretion of CXCL12 and CCL5. Read More

    A case report of disappearing pigmented skin lesions associated with pembrolizumab treatment for metastatic melanoma.
    Br J Dermatol 2017 Jan 28. Epub 2017 Jan 28.
    Memorial Sloan Kettering Cancer Center, Department of Medicine, Dermatology Service.
    Pembrolizumab is an immune checkpoint inhibitor that targets the programmed cell death (PD)-1 receptor. Common cutaneous adverse side effects of PD-1 inhibitors include maculopapular rash, pruritus, vitiligo, and lichenoid skin and mucosal reactions. Here, we describe a man in his sixties with metastatic melanoma treated with pembrolizumab who subsequently developed fading or disappearance of pigmented skin lesions, lightening of the skin, and poliosis of the eyebrows, eyelashes, and scalp and body hair. Read More

    Vitiligo blood transcriptomics provides new insights into disease mechanisms and identifies potential novel therapeutic targets.
    BMC Genomics 2017 Jan 28;18(1):109. Epub 2017 Jan 28.
    Department of Dermatology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, 6078 Clinical and Translational Research Center, 875 Ellicott Street, Buffalo, NY, 14203, USA.
    Background: Significant gaps remain regarding the pathomechanisms underlying the autoimmune response in vitiligo (VL), where the loss of self-tolerance leads to the targeted killing of melanocytes. Specifically, there is incomplete information regarding alterations in the systemic environment that are relevant to the disease state.

    Methods: We undertook a genome-wide profiling approach to examine gene expression in the peripheral blood of VL patients and healthy controls in the context of our previously published VL-skin gene expression profile. Read More

    Primary Biliary Cholangitis Associated with Skin Disorders: A Case Report and Review of the Literature.
    Arch Immunol Ther Exp (Warsz) 2017 Jan 25. Epub 2017 Jan 25.
    Dermatologia Ente Ospedaliero Cantonale, Ospedale Regionale Bellinzona, Bellinzona, Switzerland.
    Primary biliary cholangitis (PBC) is a rare autoimmune cholestatic liver disease. It is often associated with extrahepatic autoimmune diseases. Skin disorders are sporadically reported in association with PBC. Read More

    Detection of auto antibodies and transplantation of cultured autologous melanocytes for the treatment of vitiligo.
    Exp Ther Med 2017 Jan 2;13(1):23-28. Epub 2016 Dec 2.
    Department of Dermatology, Air Force General Hospital, Beijing 100036, P.R. China.
    The aim of the present study was to establish an immunofluorescence method of antibody detection to identify melanocytes in the serum of vitiligo patients. Furthermore, we aimed to establish a method for the culture and proliferation of autologous pure melanocytes and to observe the effect of their transplantation for the treatment of vitiligo. Suspension of epidermal cells with melanocytes was performed using trypsin digestion of normal epiderm from eyelid operation and melanocytes were selectively cultured and proliferated in serum-free M2 medium. Read More

    Comparative efficacy of topical application of tacrolimus and clotrimazole in the treatment of pityriasis versicolor: A single blind, randomised clinical trial.
    Mycoses 2017 Jan 25. Epub 2017 Jan 25.
    Department of Biostatistics, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
    Background: Pityriasis versicolor (PV) is a common superficial fungal disease. Possibility of emergence of resistant strains to azoles, and difficulty in differentiation of hypopigmented PV and early vitiligo, encouraged us to evaluate the efficacy of topical tacrolimus (a calcineurin inhibitor agent with proven in vitro anti-Malassezia effect) for PV treatment generally and its effect on PV-induced hypopigmentation specifically.

    Objectives: To evaluate the efficacy of topical tacrolimus on pityriasis versicolor. Read More

    Twenty-year follow-up using a postal survey of childhood vitiligo treated with narrowband ultraviolet-B phototherapy.
    Br J Dermatol 2017 Jan 24. Epub 2017 Jan 24.
    Netherlands Institute for Pigment Disorders (NIPD), Department of Dermatology, Academic Medical Centre, Amsterdam, The Netherlands.
    Vitiligo is a depigmenting skin disorder with an estimated prevalence of 1%.(1) Childhood-onset vitiligo occurs in approximately a third of all cases.(2) Early-onset childhood vitiligo tends to be a more extensive and progressive type of vitiligo. Read More

    The assessment of macular electrophysiology and macular morphology in patients with vitiligo.
    Int Ophthalmol 2017 Jan 21. Epub 2017 Jan 21.
    Department of Ophthalmology, Istanbul Medipol University, TEM Avrupa Otoyolu Cıkısı, 34214, Bagcılar, Istanbul, Turkey.
    Purpose: We aimed to analyze the electrophysiologic function and morphology of macula in vitiligo patients.

    Methods: Seventeen patients with vitiligo and 11 healthy subjects were studied. All participants underwent multifocal electroretinography (mfERG) and spectral domain optical coherence tomography (SD-OCT) evaluations. Read More

    Incident alopecia areata and vitiligo in adult women with atopic dermatitis: Nurses' Health Study 2.
    Allergy 2017 Jan 19. Epub 2017 Jan 19.
    Department of Dermatology, Warren Alpert Medical School, Providence, RI, USA.
    We aimed to determine the risk of alopecia areata (AA) and vitiligo associated with atopic dermatitis (AD) in a large cohort of US women, the Nurses' Health Study 2. We used logistic regression to calculate age- and multivariate-adjusted odds ratios to determine the risk of incident AA and vitiligo associated with AD diagnosed in or before 2009. A total of 87 406 and 87 447 participants were included in the AA and vitiligo analyses, respectively. Read More

    Vitiligo patients experience barriers in accessing care.
    Cutis 2016 Dec;98(6):385-388
    Mount Sinai St. Luke's-Roosevelt Hospital and Beth Israel Medical Centers of the Icahn School of Medicine at Mount Sinai, New York, New York, USA.
    Vitiligo is a loss of pigment occurring in approximately 0.4% to 2% of the worldwide population. The aim of this study was to determine and characterize barriers to access of care in US patients with vitiligo. Read More

    Vitiligo-like lesions occurring in patients receiving anti-programmed cell death-1 therapies are clinically and biologically distinct from vitiligo.
    J Am Acad Dermatol 2017 Jan 13. Epub 2017 Jan 13.
    Department of Dermatology and Pediatric Dermatology, National Reference Center for Rare Skin Disorders, Hôpital Saint-André, Bordeaux, France; Institut National de la Santé Et de la Recherche Médicale (INSERM) U1035, Biothérapies de Maladies Génétiques, Inflammatoires et Cancers (BMGIC), Immuno-dermatology ATIP-AVENIR, University of Bordeaux, Bordeaux, France. Electronic address:
    Background: The use of anti-programmed cell death (PD)-1 therapies in metastatic tumors is associated with cutaneous side effects including vitiligo-like lesions.

    Objective: We sought to characterize clinically and biologically vitiligo-like lesions occurring in patients receiving anti-PD-1 therapies by studying a case series of 8 patients with metastatic tumors and 30 control subjects with vitiligo.

    Methods: Eight patients receiving anti-PD-1 therapies with features of vitiligo-like lesions seen in our department were recruited. Read More

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