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    [Dermatologic toxicities of immune checkpoint inhibitors].
    Ann Dermatol Venereol 2018 Apr 17. Epub 2018 Apr 17.
    Oncodermatologie, institut universitaire du cancer Toulouse Oncopole, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.
    The development of immune checkpoint inhibitors (monoclonal antibodies targeting PD-1/PD-L1 or CTLA-4) represents a significant advance in the treatment of multiple cancers. Given their particular mechanism of action, which involves triggering CD4+/CD8+ T-cell activation and proliferation, they are associated with a specific safety profile. Their adverse events are primarily immune-related, and can affect practically all organs. Read More

    Topical Janus Kinase Inhibitors: A Review of Applications in Dermatology.
    J Am Acad Dermatol 2018 Apr 16. Epub 2018 Apr 16.
    University of California, Irvine, Department of Dermatology, Irvine, CA, 92697.
    Background: Janus kinase inhibitors (JAKi) have attracted attention for their role in treating inflammatory disorders. This new class of biologics has the potential to significantly impact the field of dermatology, especially with the development of topical formulations.

    Objective: To summarize published evidence on the efficacy, safety, and tolerability of topical JAKi in the treatment of inflammatory skin conditions. Read More

    Investigation the Relationship between Skin Involvement Severity and Hearing Loss Severity in Vitiligo Patients.
    Mater Sociomed 2018 Mar;30(1):29-31
    Department of Dermatology, Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran.
    Introduction: Vitiligo is a common acquired depigmented systemic disorder influencing the entire pigmentary system including Cochlear melanocytes and vestibular system in the inner ear. Vitiligo can leads to social negative impact and poorer quality of life among these patients. This study was conducted to investigate the relationship between skin involvement severity and hearing loss severity among vitiligo patients. Read More

    Vitiligo type cutaneous manifestation of chronic graft-versus-host disease. Case report.
    Rev Chil Pediatr 2018 Feb;89(1):113-117
    Departamento de Anatomía Patológica, Hospital Dr. Luis Calvo Mackenna, Santiago, Chile.
    Introduction: Graft-versus-host disease (GVHD) is caused by a pathologic and destructive response of the organism as a result of the interaction between donor immunocompetent T lymphocytes and the recipient tisular antigens. It's considered the most serious complication of hematopoietic stem cell transplantation, most frequently described after bone marrow transplantation (BMT). The skin is usually the first and most commonly affected organ, in both acute and chronic, with a variable clinical spectrum of presentation. Read More

    Associations of chronic urticaria with atopic and autoimmune comorbidities: a nationwide population-based study.
    Int J Dermatol 2018 Apr 16. Epub 2018 Apr 16.
    Department of Health Services Administration, China Medical University, Taichung, Taiwan.
    Background: Most cases of chronic urticaria (CU) are idiopathic. Circumstantial evidence suggests that some CU cases have an autoimmune pathogenesis. Previous research indicates that a substantial percentage of patients with CU have an atopic background. Read More

    The expression change of RORγt, BATF, and IL-17 in Chinese vitiligo patients with 308 nanometers excimer laser treatment.
    Dermatol Ther 2018 Apr 11:e12598. Epub 2018 Apr 11.
    Department of Interventional Therapy, Dong Guan People's Hospital, Guangdong Province, Dongguan 523018, People's Republic of China.
    This study aims to explore the expression of RORγt, BATF, and IL-17 in Chinese vitiligo patients with 308 nm excimer laser treatment. One hundred and sixty-four vitiligo patients treated with 308 nm excimer laser were enrolled as Case group and 137 health examiners as Control group. Quantitative real-time polymerase chain reaction and immunohistochemistry were conducted to detect the expressions of RORγt, BATF, and IL-17. Read More

    A study of the association of glutathione S-transferase M1/T1 polymorphisms with susceptibility to vitiligo in Egyptian patients.
    An Bras Dermatol 2018 Jan-Feb;93(1):54-58
    Department of Dermatology and Venereology, National Research Centre - Giza, Egypt.
    Background: The association of glutathione S-transferases M1/T1 (GSTM1/T1) null polymorphisms with vitiligo was proposed in several studies including two Egyptian studies with contradictory results.

    Objective: The aim here was to assess the association between GSTM1/T1 null polymorphisms and the susceptibility to vitiligo in a larger sample of Egyptian patients with generalized vitiligo.

    Methods: This study included 122 vitiligo patients and 200 healthy controls that were age, and gender matched. Read More

    Mycetomas: an epidemiological, etiological, clinical, laboratory and therapeutic review.
    An Bras Dermatol 2018 Jan-Feb;93(1):8-18
    Dermatologic Surgery Clinic and Vitiligo Clinic of the Regional Hospital of Asa Norte (HRAN) - Brasília (FD), Brazil.
    Mycetoma is a chronic suppurative disease of the skin and subcutaneous tissue, characterized by a symptomatic triad: tumor, fistulas and grains. It can be caused by fungi (eumycetoma) and bacteria (actinomycetoma), with similar clinical features. Diagnosis is based on the clinical presentation and identification of the etiological agents in the tissue, by mycological/bacteriological, histopathological and immunohistochemical tests. Read More

    A preliminary study of growth characteristics of melanocytes co-cultured with keratinocytes in vitro.
    J Cell Biochem 2018 Apr 10. Epub 2018 Apr 10.
    Department of Dermatology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
    To clarify the characteristic growth of melanocytes (MCs) and Keratinocytes (KCs) in vitro and discuss the mechanism of culturing autologous melanocytes in the treatment of vitiligo. Epidermis cells derived from normal skin tissues were isolated and cultured in vitro. Melanocytes in DOPA staining were observed. Read More

    Preliminary study on the treatment of vitiligo with carbon dioxide fractional laser together with tacrolimus.
    Lasers Surg Med 2018 Apr 10. Epub 2018 Apr 10.
    Department of Dermatology, The First Affiliated Hospital with Nanjing Medical University, Guangzhou Road 300, Nanjing City, Jiangsu Province, China 210029.
    Background: Tacrolimus is a conventional medication for the treatment of vitiligo, but the effect of a single medication is limited.

    Objective: This paper aims at observing the effects, adverse responses, and repigmentation results of the joint treatment of vitiligo by Carbon dioxide (CO ) fractional laser together with tacrolimus.

    Methods: Forty-five patients with vitiligo were randomly divided into two groups: treatment (T) group and control (C) group, and each group was further divided into three subgroups (face, torso and limbs, and hand and foot) according to the location of the skin defect. Read More

    Concurrent extrahepatic autoimmune disorders: unexplored dimension of autoimmune liver disease in children.
    Eur J Gastroenterol Hepatol 2018 Apr 9. Epub 2018 Apr 9.
    Departments of Pediatric Gastroenterology.
    Background And Aim: No comprehensive and prospective data are available for concurrent extrahepatic autoimmune disorders (CEAIDs) in children with autoimmune liver disease (AILD). The aim of this study was to evaluate CEAIDs in AILD and their effect on AILD outcome.

    Patients And Methods: Enrolled AILD and CEAIDs children were diagnosed on the basis of simplified and standard diagnostic criteria, respectively. Read More

    Anti-Melanoma immunity and local regression of cutaneous metastases in melanoma patients treated with monobenzone and imiquimod; a phase 2 a trial.
    Oncoimmunology 2018 15;7(4):e1419113. Epub 2018 Jan 15.
    Dept. of Dermatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
    Vitiligo development in melanoma patients during immunotherapy is a favorable prognostic sign and indicates breakage of tolerance against melanocytic/melanoma antigens. We investigated a novel immunotherapeutic approach of the skin-depigmenting compound monobenzone synergizing with imiquimod in inducing antimelanoma immunity and melanoma regression. Stage III-IV melanoma patients with non-resectable cutaneous melanoma metastases were treated with monobenzone and imiquimod (MI) therapy applied locally to cutaneous metastases and adjacent skin during 12 weeks, or longer. Read More

    Association of interleukin 1 receptor antagonist intron 2 variable number of tandem repeats polymorphism with vitiligo susceptibility in Gujarat population.
    Indian J Dermatol Venereol Leprol 2018 May-Jun;84(3):285-291
    Department of Biochemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India.
    Background: Vitiligo is a multifactorial, polygenic, autoimmune skin disorder caused by selective destruction of melanocytes. Interleukin 1 receptor antagonist intron 2 polymorphism was found to be associated with various autoimmune disorders.

    Aims: We aimed to investigate the association of interleukin 1 receptor antagonist intron 2 variable number of tandem repeats polymorphism (rs2234663) with vitiligo to assess interleukin 1 receptor antagonist transcript levels and to perform possible genotype-phenotype correlation. Read More

    Home interventions and light therapy for the treatment of vitiligo (HI-Light Vitiligo Trial): study protocol for a randomised controlled trial.
    BMJ Open 2018 Apr 3;8(4):e018649. Epub 2018 Apr 3.
    Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, UK.
    Introduction: Vitiligo is a condition resulting in white patches on the skin. People with vitiligo can suffer from low self-esteem, psychological disturbance and diminished quality of life. Vitiligo is often poorly managed, partly due to lack of high-quality evidence to inform clinical care. Read More

    IL-17 induces cellular stress microenvironment of melanocytes to promote autophagic cell apoptosis in vitiligo.
    FASEB J 2018 Apr 3:fj201701242RR. Epub 2018 Apr 3.
    State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
    Vitiligo is a depigmentary disorder that develops as a result of the progressive disappearance of epidermal melanocytes. Stress can precipitate or exacerbate a skin disease through psychosomatic mechanisms. Stress exposure induces vitiligo-like symptoms in mice, as cellular damage to melanocytes cause synthetic pigment loss. Read More

    Increased tenascin C and DKK1 in vitiligo: possible role of fibroblasts in acral and non-acral disease.
    Arch Dermatol Res 2018 Mar 31. Epub 2018 Mar 31.
    Biochemistry Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
    Recently, multiple culprits-in addition to melanocytes-have been implicated in the pathogenesis of vitiligo. Among those factors are fibroblasts. However, their exact role has not been clearly elucidated. Read More

    Non-malignant late cutaneous changes after allogeneic hematopoietic stem cell transplant in children.
    J Am Acad Dermatol 2018 Mar 24. Epub 2018 Mar 24.
    Harvard Medical School; Boston, MA; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Boston, MA; Division of Hematology/Oncology, Boston Children's Hospital; Boston, MA.
    Background: There are limited pediatric data on non-malignant cutaneous changes, including autoimmune conditions and permanent alopecia, after hematopoietic stem cell transplantation (HSCT).

    Objective: We sought to characterize late cutaneous changes and associated risk factors after allogeneic HSCT in children.

    Methods: A cross-sectional cohort study of pediatric HSCT recipients was performed at a single institution. Read More

    Utility of dermoscopy for evaluating the therapeutic efficacy of tacrolimus ointment plus 308-nm excimer laser combination therapy in localized vitiligo patients.
    Exp Ther Med 2018 Apr 28;15(4):3981-3988. Epub 2018 Feb 28.
    Department of Dermatology, Dong Guan People's Hospital, Dongguan, Guangdong 523018, P.R. China.
    The aim of the present study was to assess the function of dermoscopy in evaluating the therapeutic efficacy of tacrolimus ointment plus 308-nm excimer laser combination therapy in patients with localized vitiligo. A total of 147 patients with localized vitiligo (progressive disease, n=92; stable period, n=55) were enrolled and received combination therapy for 12 weeks. The condition of the skin lesions was monitored by dermoscopy and visual observation. Read More

    Regulatory T cells in autoimmune skin diseases.
    Exp Dermatol 2018 Mar 25. Epub 2018 Mar 25.
    Department of Dermatology, Hokkaido University Graduate School of Medicine.
    CD4 Foxp3 regulatory T cells (Tregs) are suppressors of immune activation and play a crucial role in the maintenance of peripheral tolerance. Mutations of Foxp3 result in fatal autoimmunity in multiple organs, including the skin, in both humans and mice. Many studies have demonstrated the altered frequency and functions of Tregs, changes in cytokine and chemokine levels related to Tregs, and the differences in genetic background regarding Tregs in autoimmune skin disorders. Read More

    The role of phototherapy in the surgical treatment of vitiligo: a systematic review.
    J Eur Acad Dermatol Venereol 2018 Mar 24. Epub 2018 Mar 24.
    Netherlands Institute for Pigment Disorders, Academic Medical Centre, Amsterdam, The Netherlands.
    Vitiligo is frequently treated with the combination of phototherapy and melanocyte transplantation. However, the additional benefit of phototherapy is unclear. Moreover, the optimal type and regimen of phototherapy is unknown. Read More

    Automated Scoring of Vitiligo Using Superpixel-Generated Computerized Digital Image Analysis of Clinical Photographs: A Novel and Consistent Way to Score Vitiligo.
    Br J Dermatol 2018 Mar 24. Epub 2018 Mar 24.
    National Skin Centre - Dermatology,, 1 Mandalay Road Singapore, 308205, Singapore.
    Objective outcome measures for vitiligo are essential for evaluation of severity and response to treatment. Vitiligo Area Scoring Index score (VASI) [1,2] is a validated tool for assessing severity of vitiligo. However, estimation of area and extent of depigmentation in VASI is often subject to much inter- and intra-observer variability [3] This article is protected by copyright. Read More

    Sex- and age-adjusted prevalence estimates of five chronic inflammatory skin diseases in France: results of the « OBJECTIFS PEAU » study.
    J Eur Acad Dermatol Venereol 2018 Mar 23. Epub 2018 Mar 23.
    Société Française de Dermatologie (SFD), Paris, France.
    Background: There are few population-based studies assessing the prevalence of skin diseases.

    Objectives: To estimate the prevalence of five chronic skin inflammatory diseases, i.e. Read More

    General survey of Fructus Psoraleae from the different origins and chemical identification of the roasted from raw Fructus Psoraleae.
    J Food Drug Anal 2018 Apr 1;26(2):807-814. Epub 2017 Dec 1.
    Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; Research and Development Center of TCM, Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China. Electronic address:
    Fructus Psoraleae, a traditional Chinese medicine, is widely used for preventing and treating various diseases such as vitiligo, osteoporosis and psoriasis. Coumarin, such as psoralenoside, isopsoralenoside, psoralen and isopsoralen, are important compounds in Fructus Psoraleae. In our study, ultra performance liquid chromatography coupled with diode array detector was employed for an excellent method validation for simultaneous quantification of psoralenoside, isopsoralenoside, psoralen and isopsoralen, which was further applied in performing general survey of Fructus Psoraleae from the different origins and chemical identification of the roasted from raw Fructus Psoraleae in the light of illuminating the transformed rule of psoralenoside and isopsoralenoside. Read More

    Rheumatoid arthritis in an adult patient with mosaic distal 18q-, 18p- and ring chromosome 18.
    F1000Res 2017 2;6:1940. Epub 2017 Nov 2.
    Department of Medicine, Montefiore Medical Center, Bronx, New York City, NY, USA.
    Ring chromosome 18 has a highly variable phenotype, depending on the extent of distal arm deletions. It is most commonly presented as a combination of 18p- and distal 18q- syndrome. IgA deficiency and autoimmune diseases have been previously described in these patients. Read More

    Epidemiological and clinical aspects of autoimmune thyroid diseases in children with Down's syndrome.
    Ital J Pediatr 2018 Mar 21;44(1):39. Epub 2018 Mar 21.
    Department of Human Pathology in Adulthood and Childhood, University of Messina, Via Consolare Valeria, 98124, Messina, Italy.
    Aim of this commentary is to report the main peculiarities that have been found to characterize the phenotypic expression of autoimmune thyroid diseases (AITDs) in children with Down's syndrome (DS). According to recent reports, DS children are, per se, more exposed to the risk of both Hashimoto's thyroiditis (HT) and Graves' disease (GD), irrespective of other concomitant risk factors, such as female gender and family antecedents for AITDs. In the context of extra-thyroidal autoimmune disorders, the ones that preferentially aggregate with AITDs in DS children are alopecia areata and vitiligo. Read More

    In Vitro TyRP-1 Knockdown Based on siRNA Carried by Liquid Crystalline Nanodispersions: an Alternative Approach for Topical Treatment of Vitiligo.
    Pharm Res 2018 Mar 20;35(5):104. Epub 2018 Mar 20.
    School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Avenida do Café, s/n, Ribeirão Preto, SP, 14040-903, Brazil.
    Purpose: Vitiligo is a skin disease characterized by depigmentation and the presence of white patches that are associated with the loss of melanocytes. The most common explanation for the cause of this condition is that it is an autoimmune condition. TyRP-1 is involved in melanin pigment synthesis but can also function as a melanocyte differentiation antigen. Read More

    Prevalence of choroidal nevus and retinal pigment epithelial alterations in vitiligo patients.
    Graefes Arch Clin Exp Ophthalmol 2018 Mar 16. Epub 2018 Mar 16.
    Division of Ophthalmology, Tel Aviv Sourasky Medical Center, Weizman 6, 6423906, Tel Aviv, Israel.
    Purpose: To investigate ocular manifestations in patients with vitiligo by multimodal imaging, including optical coherence tomography (OCT), color fundus photography, and fundus autofluorescence (FAF).

    Methods: In this prospective, observational clinical study, vitiligo patients underwent ophthalmologic and dermatologic clinical assessment and imaging by spectral-domain OCT, FAF, and color fundus imaging. Ocular echography was performed as indicated. Read More

    The effects of phototherapy and melanocytes on keratinocytes.
    Exp Ther Med 2018 Apr 30;15(4):3459-3466. Epub 2018 Jan 30.
    Department of Dermatology, Huashan Hospital of Fudan University, Shanghai 200040, P.R. China.
    Phototherapy is widely used in the treatment of vitiligo. Previous studies have focused on the effects of ultraviolet (UV) radiation on melanocytes; however, the biological effects of phototherapy and melanocytes on keratinocytes remain to be elucidated. To investigate and assess the effects of clinically doses of broad band (BB)-UVA, narrow band (NB)-UVB and melanocytes on human keratinocytes , clinical doses of BB-UVA or NB-UVB radiation and human melanoma cell A375 co-culture were performed as stress divisors to HaCaT cells. Read More

    Cutaneous carcinogenic risk evaluation in 375 patients treated with narrowband-UVB phototherapy: A 15-year experience from our Institute.
    Photodermatol Photoimmunol Photomed 2018 Mar 13. Epub 2018 Mar 13.
    Division of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
    Background: Narrowband-ultraviolet B (NB-UVB) is widely used for the treatment of several dermatological diseases. A cutaneous carcinogenic effect has been hypothesized, but not proved.

    Methods: We retrospectively reviewed the data of patients treated with NB-UVB between January 1998 and December 2013 at the Dermatology Unit of our University Hospital, to evaluate the cutaneous carcinogenic risk of NB-UVB. Read More

    Comparison between the efficacy of microneedling combined with 5-fluorouracil vs microneedling with tacrolimus in the treatment of vitiligo.
    J Cosmet Dermatol 2018 Mar 12. Epub 2018 Mar 12.
    Faculty of Medicine, Department of Dermatology & Venereology, Tanta University, Tanta, Egypt.
    Background: Several treatment modalities had been used for the treatment of vitiligo, but the optimal treatment has not yet been identified.

    Objectives: To study the efficacy of microneedling with 5-flurouracil vs its efficacy with tacrolimus in the treatment of vitiligo.

    Patients And Methods: Twenty-five patients with vitiligo were subjected to microneedling of 2 patches of vitiligo with dermapen, then application of 5-fluorouracil to 1 patch and tacrolimus on the other patch. Read More

    Effect of narrow-band ultraviolet B on the serum of 25-hydroxyvitamin D in vitiligo patients.
    J Cosmet Dermatol 2018 Mar 10. Epub 2018 Mar 10.
    Department of Clinical Pathology, Faculty of Medicine, South Valley University, Qena, Egypt.
    Background: Narrow-band ultraviolet B (NB-UVB) is the gold standard in the treatment of vitiligo. 25-hydroxyvitamin D (25-OH- vitamin D) might play a physiological role in photo-induced melanogenesis in human skin so the association between vitamin D levels and vitiligo still needs to be investigated more thoroughly.

    Objective: we aim to investigate the influence of cumulative doses of NB-UVB phototherapy on vitamin D in patients with vitiligo and their correlation with NB-UVB-induced pigmentation. Read More

    Neutrophil to lymphocyte ratio in patients with vitiligo.
    Postepy Dermatol Alergol 2017 Oct 31;34(5):468-470. Epub 2017 Oct 31.
    Department of Dermatology, Faculty of Medicine, Sakarya University, Sakarya, Turkey.
    Introduction: There are a few studies showing an increased risk of insulin resistance, metabolic syndrome, and oxidative stress in patients with vitiligo.

    Aim: To investigate whether systemic inflammation is increased in vitiligo patients in a case-control study design.

    Material And Methods: Nonsegmental vitiligo patients who had been followed at the outpatient dermatology clinic of a university-affiliated teaching hospital, and healthy controls were enrolled in the study. Read More

    Geniposide prevents H O -induced oxidative damage in melanocytes by activating the PI3K-Akt signalling pathway.
    Clin Exp Dermatol 2018 Mar 7. Epub 2018 Mar 7.
    Department of Dermatology, Qilu Hospital of Shandong University, Jinan, China.
    Background: Oxidative stress is one possible pathogenic event in vitiligo that induces melanocyte destruction. Geniposide exerts certain antioxidant effects on various cells by activating the phosphoinositol 3-kinase (PI3K)-Akt signalling pathway. However, researchers have not clearly determined whether geniposide protects human melanocytes from oxidative stress or identified the underlying mechanism of such protection. Read More

    A novel psoralen derivative-MPFC enhances melanogenesis via activation of p38 MAPK and PKA signaling pathways in B16 cells.
    Int J Mol Med 2018 Jun 2;41(6):3727-3735. Epub 2018 Mar 2.
    The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, Xinjiang 830011, P.R. China.
    As an active compound, psoralen is present in various Chinese herbal medicines and has exhibited significant activity in skin disease treatment. Its derivative 8-methoxypsoralan (8-MOP) is the most commonly used drug to induce repigmentation of vitiligo. In our previous screening assays, 4-methyl-6-phenyl-2H-furo[3,2-g]chromen-2-one (MPFC), a psoralen derivative, was identified as more effective tyrosinase and melanin activator than the positive control 8-MOP in consideration of low doses, as well as low toxicity. Read More

    Classification of facial vitiligo: A cluster analysis of 473 patients.
    Pigment Cell Melanoma Res 2018 Mar 6. Epub 2018 Mar 6.
    Korea Institute of Vitiligo Research, Seoul, Korea.
    Vitiligo has a substantial negative impact on quality of life in affected patients, especially those with the involvement of the face. However, the current system can barely distinguish between specific patterns of facial involvement except for the segmental type when focusing only on facial lesions. We classified facial vitiligo into three distinct subtypes using cluster analysis based on facial topography (n = 473): centrofacial vitiligo (72. Read More

    Depigmented plaques on vulva.
    J Fam Pract 2018 Mar;67(3):171-174
    Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    A mother brought her 8-year-old daughter to our office for evaluation of vitiligo "down there". The skin eruption first appeared on her vulva a year earlier and was intermittently pruritic. The lesions were initially smaller and red, but had since lightened in color, coalesced, and had begun to spread to the perianal area. Read More

    Novel Furocoumarin Derivatives Stimulate Melanogenesis in B16 Melanoma Cells by Up-Regulation of MITF and TYR Family via Akt/GSK3β/β-Catenin Signaling Pathways.
    Int J Mol Sci 2018 Mar 6;19(3). Epub 2018 Mar 6.
    Key Laboratory of Plant Resources and Chemistry of Arid Zone, State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China.
    The extracts of L. and L. are traditional Uygur medicines for the treatment of vitiligo, and its active ingredients furocoumarins, were are found to be the most effective agents against this skin disorder nowadays. Read More

    Cytokine profile (IL-2, IL-6, IL-17, IL-22, and TNF-α) in vitiligo-New insight into pathogenesis of disease.
    J Cosmet Dermatol 2018 Mar 4. Epub 2018 Mar 4.
    Department of Biochemistry, Dr. Ram Manohar Lohia Hospital and PGIMER, New Delhi, India.
    Background: Vitiligo is an autoimmune disease associated with alteration in levels of various cytokines. However, there are very few studies in this regard.

    Objectives: To assess the serum levels of cytokines secreted by Th1 (IL-2, TNF-α), Th2 (IL-6), and Th17 cells (IL-17, IL-22) in patients with localized vitiligo and generalized vitiligo and to correlate their levels with the extent, duration, and activity of disease. Read More

    Protective effects of glutamine on human melanocyte oxidative stress model.
    Indian J Dermatol Venereol Leprol 2018 May-Jun;84(3):269-274
    Department of Dermatology, Qilu Hospital, Shandong University, Jinan, 250012, P. R. China.
    Background: Vitiligo is a disorder caused by the loss of the melanocyte activity on melanin pigment generation. Studies show that oxidative-stress induced apoptosis in melanocytes is closely related to the pathogenesis of vitiligo. Glutamine is a well known antioxidant with anti-apoptotic effects, and is used in a variety of diseases. Read More

    Vitiligo in Children: What's New in Treatment?
    Open Access Maced J Med Sci 2018 Jan 21;6(1):221-225. Epub 2018 Jan 21.
    University G. Marconi of Rome, Dermatology and Venereology, Rome, Italy.
    Vitiligo is an acquired chronic hypopigmentary disorder, which usually stars in childhood. The Authors discuss a short review of the more innovative therapies for childhood vitiligo. Read More

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