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    2400 results match your criteria Vitamin K Deficiency

    1 OF 48

    Coagulopathy in Zellweger spectrum disorders: a role for vitamin K.
    J Inherit Metab Dis 2017 Nov 14. Epub 2017 Nov 14.
    Department of Pediatric Hematology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands.
    Introduction: Zellweger spectrum disorders (ZSDs) are caused by an impairment of peroxisome biogenesis, resulting in multiple metabolic abnormalities. This leads to a range of symptoms, including hepatic dysfunction and coagulopathy. This study evaluated the incidence and severity of coagulopathy and the effect of vitamin K supplementation orally and IV in ZSD. Read More

    Vitamin K deficiency: the linking pin between COPD and cardiovascular diseases?
    Respir Res 2017 Nov 13;18(1):189. Epub 2017 Nov 13.
    Department of Pulmonary Medicine, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands.
    Cardiovascular diseases are prevalent in patients with chronic obstructive pulmonary disease (COPD). Their coexistence implies that many COPD patients require anticoagulation therapy. Although more and more replaced by direct oral anticoagulants, vitamin K antagonists (VKAs) are still widely used. Read More

    Acquired Vitamin K Deficiency as Unusual Cause of Bleeding Tendency in Adults: A Case Report of a Nonhospitalized Student Presenting with Severe Menorrhagia.
    Case Rep Obstet Gynecol 2017 27;2017:4239148. Epub 2017 Aug 27.
    Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
    We report a rare case of acquired vitamin K deficiency presenting with severe menorrhagia and without any gynecological problem. Partial thromboplastin time (59.2 seconds) and prothrombin time (33. Read More

    Role of Fat-Soluble Vitamins in Osteoarthritis Management.
    J Clin Rheumatol 2017 Sep 19. Epub 2017 Sep 19.
    From the *Department of Orthopedics, Second People's Hospital of Jingmen, Jingmen; and †Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.
    Osteoarthritis (OA) is a chronic degenerative joint disease, in which metabolic imbalance in bone is observed. The pathological mechanism of metabolic imbalance is not clear yet, but the nutritional factors, particularly the vitamins, might be intrinsic to the development and progression of OA. In this review article, we have explored databases such as PubMed, Scopus, and Google Scholar articles until the beginning of 2017 and reviewed the role of fat-soluble vitamins in pathological and therapeutic aspects of OA. Read More

    Hypoprothrombinemia and severe perioperative haemorrhagic complications in cardiac surgery patients treated with high-dose cefazolin for infective endocarditis.
    Anaesth Crit Care Pain Med 2017 Sep 1. Epub 2017 Sep 1.
    Department of Anaesthesia and Critical Care II, CHU Bordeaux, 33600 Pessac, France; UMR 1034, Inserm, Biology of Cardiovascular Diseases, University Bordeaux, 33600 Pessac, France. Electronic address:
    Endocarditis is a serious and common disease that requires prolonged antimicrobial therapy. The recent shortage of oxacillin has led to the use of other antimicrobial agents such as cefazolin to treat endocarditis due to methicillin-sensitive Staphylococcus aureus. We describe four cases of life-threatening haemorrhagic complications (fatal in two cases) in patients treated with high-dose cefazolin. Read More

    Vitamin K supplementation for cystic fibrosis.
    Cochrane Database Syst Rev 2017 08 22;8:CD008482. Epub 2017 Aug 22.
    Department of Paediatrics, American Mission Hospital, Manama, Manama, Bahrain, PO Box 1.
    Background: Cystic fibrosis is a genetic disorder which can lead to multiorgan dysfunction. Malabsorption of fat and fat-soluble vitamins (A, D, E, K) may occur and can cause subclinical deficiencies of some of these vitamins. Vitamin K is known to play an important role in both blood coagulation and bone formation. Read More

    Vitamin K2 supplementation and arterial stiffness among renal transplant recipients-a single-arm, single-center clinical trial.
    J Am Soc Hypertens 2017 Sep 13;11(9):589-597. Epub 2017 Jul 13.
    Lebanese American University School of Medicine, Byblos, Lebanon; Division of Nephrology and Transplantation, Department of Medicine, Lebanese American University Medical Center-Rizk Hospital, Beirut, Lebanon. Electronic address:
    Subclinical vitamin K deficiency is prevalent among renal transplant recipients and is associated with an increased risk of cardiovascular disease. However, the association between vitamin K supplementation and improvement of arterial stiffness has not been explored in the renal transplant population. The KING trial (vitamin K2 In reNal Graft) is a single-arm study that evaluated the association between the change in vitamin K status and indices of arterial stiffness following 8 weeks of menaquinone-7 (vitamin K2) supplementation (360 μg once daily) among renal transplant recipients (n = 60). Read More

    Chondrodysplasia Punctata: A Case Report of Fetal Warfarin Syndrome.
    J Nepal Health Res Counc 2017 Jan;15(35):81-84
    Department of Radiology and Imaging, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.
    Chondrodysplasia punctata is abnormal calcification in the cartilage of developing bones and has been seen in association with deranged vitamin K metabolism. Warfarin, an oral anticoagulant acting on vitamin K dependent clotting factors is known to cause chondrodysplasia punctata. Despite the knowledge of the condition the management of patients with prosthetic heart valves might require use of the drug for anticoagulation. Read More

    Intrahepatic Cholestasis of Pregnancy Leading to Severe Vitamin K Deficiency and Coagulopathy.
    Case Rep Obstet Gynecol 2017 7;2017:5646247. Epub 2017 Jun 7.
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA.
    Intrahepatic cholestasis of pregnancy is seldom associated with significant vitamin K deficiency. We report a case of a 16-year-old primigravid patient at 24 weeks and 3 days of gestation who presented with pruritus, hematuria, and preterm labor. Laboratory work-up showed severe coagulopathy with Prothrombin Time (PT) of 117. Read More

    High Dephosphorylated-Uncarboxylated MGP in Hemodialysis patients: risk factors and response to vitamin K2, A pre-post intervention clinical trial.
    BMC Nephrol 2017 Jun 7;18(1):191. Epub 2017 Jun 7.
    Head of the Nephrology Department, Hôtel Dieu de France, Beirut. Saint-Joseph University, Beirut, Lebanon.
    Background: Vascular calcifications are highly prevalent in hemodialysis patients. Dephosphorylated-uncarboxylated MGP (dp-ucMGP) was found to increase in vitamin K-deficient patients and may be associated with vascular calcifications. Supplementation of hemodialysis patients with vitamin K2 (menaquinone-7) has been studied in Europe with a maximum 61% drop of dp-ucMGP levels. Read More

    [Intracranial hemorrhage secondary to vitamin K deficiency in an infant despite oral vitamin K prophylaxis : Also a challenge for the anesthesiologist].
    Anaesthesist 2017 Jun 2. Epub 2017 Jun 2.
    I. Klinik für Kinder und Jugendliche, Klinikum Augsburg, Augsburg, Deutschland.
    This article presents the case of a 6-week-old infant who, despite oral vitamin K prophylaxis and otherwise normal developmental progress, suffered a severe intracerebral and subdural hemorrhage, which required surgical evacuation. The interdisciplinary approach is described with emphasis on the management of hemostasis. Furthermore, the clinical picture of intracranial bleeding due to vitamin K deficiency, which is nowadays rare in the Western World, is described in the anesthesiology literature for the first time. Read More

    Nonhealing, progressive stress fractures of the foot in a 13-year-old basketball player: is vitamin K deficiency a risk factor?
    J Phys Ther Sci 2017 Apr 20;29(4):763-766. Epub 2017 Apr 20.
    Department of Physical Medicine and Rehabilitation, Acıbadem University School of Medicine, Turkey.
    [Purpose] To report an adolescent male basketball player with nonhealing stress fractures of the foot and discuss the probable factors. [Subject and Methods] A 13-year-old basketball player presented with right foot pain. He had been playing basketball for three years and practicing 5 days/week. Read More

    Phosphate binders affect vitamin K concentration by undesired binding, an in vitro study.
    BMC Nephrol 2017 May 2;18(1):149. Epub 2017 May 2.
    Department of Nephrology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
    Background: Vascular calcification is a major contributing factor to mortality in end stage renal disease (ESRD). Despite the efficacy of phosphate binders to improve hyperphosphatemia, data on vascular calcification are less clear. There seems to be a difference in attenuation or delay in progression between different binders. Read More

    The Coags Uncomplicated App: Fulfilling Educational Gaps Around Diagnosis and Laboratory Testing of Coagulation Disorders.
    JMIR Med Educ 2017 Apr 18;3(1):e6. Epub 2017 Apr 18.
    Novo Nordisk Inc., Plainsboro, NJ, United States.
    Background: Patients with coagulation disorders may present to a variety of physician specialties; however, accurate and efficient diagnosis can be challenging for physicians not specialized in hematology, due to identified gaps in knowledge around appropriate laboratory assays and interpretation of test results. Coags Uncomplicated was developed to fill this unmet educational need by increasing practical knowledge of coagulation disorders among nonexpert physicians and other health care professionals (HCPs) in a point-of-care (POC) setting.

    Objective: The aim of this study was to assess patterns of use of the mobile app Coags Uncomplicated, a tool designed to support education regarding accurate and efficient diagnosis of bleeding disorders. Read More

    Finding the optimal dose of vitamin K1 to treat vitamin K deficiency and to avoid anaphylactoid reactions.
    Fundam Clin Pharmacol 2017 Oct 24;31(5):495-505. Epub 2017 May 24.
    Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, 76 Yanta West Road, Xi'an, 710061, China.
    Vitamin K1 injection induces severe dose-related anaphylactoid reactions and overdose for the treatment of vitamin K deficiency. We aimed to find an optimal and small dose of vitamin K1 injection to treat vitamin K deficiency and avoid anaphylactoid reactions in animal. Rats were administered a vitamin K-deficient diet and gentamicin to establish vitamin K deficiency model. Read More

    Joint Association of Low Vitamin D and Vitamin K Status With Blood Pressure and Hypertension.
    Hypertension 2017 Jun 10;69(6):1165-1172. Epub 2017 Apr 10.
    From the Department of Health Sciences, and the EMGO Institute for Health and Care Research (A.J.v.B., A.C., M.V., I.A.B.), Department of Internal Medicine, Section of Nutrition and Dietetics (M.V.), and Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research (N.M.v.S., J.W.B.), VU University Medical Center, Amsterdam; and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht (J.W.B.).
    Low vitamin D and K status are both associated with an increased cardiovascular risk. New evidence from experimental studies on bone health suggest an interaction between vitamin D and K; however, a joint association with vascular health outcomes is largely unknown. To prospectively investigate whether the combination of low vitamin D and K status is associated with higher systolic and diastolic blood pressure in 402 participants and with incident hypertension in 231 participants free of hypertension at baseline. Read More

    Calciphylaxis.
    Curr Opin Nephrol Hypertens 2017 Jul;26(4):276-281
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
    Purpose Of Review: Calciphylaxis remains a poorly understood vascular calcification disorder with predilection for patients with end-stage renal disease (ESRD). Recent data from large patient registries and databases have begun to provide information regarding incidence, risk factors, and outcomes in patients with calciphylaxis.

    Recent Findings: The most recent estimate places the incidence of calciphylaxis at 3. Read More

    Detection of subclinical vitamin K deficiency in neurosurgery with PIVKA-II.
    Scand J Clin Lab Invest 2017 Jul 20;77(4):267-274. Epub 2017 Mar 20.
    a Department of Anaesthesia and Intensive Care, Institution of Clinical Science Lund, Medical Faculty , Lund University , Lund , Sweden.
    Vitamin K is known for supporting the carboxylation of hepatic coagulation proteins. Levels of proteins induced by vitamin K absence for factor II (PIVKA-II) reflect hypocarboxylated prothrombin and can be used to detect subclinical vitamin K deficiency. The aim of this study was to determine the prevalence of perioperative subclinical vitamin K deficiency among neurosurgical patients using PIVKA-II and investigate the existence of any correlation to standard coagulation assays. Read More

    The Strategy to Prevent and Regress the Vascular Calcification in Dialysis Patients.
    Biomed Res Int 2017 14;2017:9035193. Epub 2017 Feb 14.
    Division of Nephrology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Department of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan.
    The high prevalence of arterial calcification in end-stage renal disease (ESRD) is far beyond the explanation by common cardiovascular risk factors such as aging, diabetes, hypertension, and dyslipidemia. The finding relies on the fact that vascular and valvular calcifications are predictors of cardiovascular diseases and mortality in persons with chronic renal failure. In addition to traditional cardiovascular risk factors such as diabetes mellitus and blood pressure control, other ESRD-related risks such as phosphate retention, excess calcium, and prolonged dialysis time also contribute to the development of vascular calcification. Read More

    Susceptiveness of Vitamin K epOxide Reductase Complex Subunit 1 Gene Polymorphism in Essential Hypertension.
    Genet Test Mol Biomarkers 2017 May 10;21(5):292-297. Epub 2017 Mar 10.
    1 Department of Medical Biology, Faculty of Medicine, Eskisehir Osmangazi University , Eskisehir, Turkey .
    Background: Essential hypertension (EH) is defined as a worldwide public health problem and one of the important risk factors for development of human coronary artery disease. Increased peripheral arterial resistance is one of the distinguishing characteristics of EH. The extracellular deposition of calcium in the arterial wall is defined as vascular calcification, which results in aortic stiffness and elevation of blood pressure. Read More

    Effectiveness of prothrombin complex concentrate (PCC) in neonates and infants with bleeding or risk of bleeding: a systematic review and meta-analysis.
    Eur J Pediatr 2017 May 9;176(5):581-589. Epub 2017 Mar 9.
    Department of Neonatology, West China Second University Hospital, Sichuan University, Chengdu, China.
    To systematically evaluate the effectiveness of prothrombin complex concentrate (PCC) in neonates and infants, we performed a systematic review and meta-analysis based on current evidence. Quality of studies was assessed by Cochrane Collaboration's risk of bias tool and Newcastle-Ottawa quality assessment scale. For dichotomous data, we obtained the number of events and total number and calculated the relative risk (RR) with 95% confidence intervals (CI). Read More

    Vitamin K Deficiency Presenting in an Infant with an Anterior Mediastinal Mass: A Case Report and Review of the Literature.
    Case Rep Pediatr 2017 9;2017:7628946. Epub 2017 Feb 9.
    School of Medicine, University of Colorado, Boulder, CO, USA.
    We report a case of a 1-month-old infant with spontaneous thymic hemorrhage secondary to severe vitamin K deficiency. He was brought to medical attention due to scrotal bruising and during evaluation was noted to be tachypneic and hypoxemic. Chest X-ray revealed an enlarged cardiothymic silhouette, and a follow-up echocardiogram revealed a mass in the anterior mediastinum. Read More

    Refusal of Vitamin K by Parents of Newborns: A Survey of the Better Outcomes Through Research for Newborns Network.
    Acad Pediatr 2017 May - Jun;17(4):368-373. Epub 2017 Mar 9.
    Department of Pediatrics, Yale University, New Haven, Conn.
    Objective: To survey newborn clinicians in the United States regarding the frequency of intramuscular (IM) vitamin K refusal by a parent, reasons for refusal, and approaches of clinicians to refusals.

    Methods: An electronic survey was administered to the clinician site representative (nursery director or designee knowledgeable about site-specific nursery policies) at all newborn nurseries in the Better Outcomes through Research for Newborns (BORN) network of newborn nurseries.

    Results: Of 92 BORN sites, 85 (92%) respondents completed the survey. Read More

    The Presentation of a Fussy Infant With Bruising: Late-Onset Vitamin K Deficiency Bleeding.
    Pediatr Emerg Care 2017 Feb 21. Epub 2017 Feb 21.
    From the *Department of Pediatrics and †Division of Pediatric Emergency Medicine, University of Utah, Salt Lake City, UT.
    Vitamin K plays an integral role in the clotting cascade. Deficiency, specifically in vulnerable neonates with insufficient stores, can lead to spontaneous bleeding and devastating effects. In this case, we report a young infant with late-onset vitamin K deficiency bleeding who did not receive vitamin K prophylaxis after birth. Read More

    Vitamin K status in cystic fibrosis patients with liver cirrhosis.
    Dig Liver Dis 2017 Jun 23;49(6):672-675. Epub 2017 Jan 23.
    Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznan, Poland. Electronic address:
    The available data on the influence of liver cirrhosis on vitamin K status in CF patients is scarce. Therefore, the aims of the present study were to assess the prevalence of vitamin K deficiency in cirrhotic CF subjects and to determine whether it correlates with liver cirrhosis. The study group comprised of 27 CF patients with and 63 without liver cirrhosis. Read More

    Diagnostic Error of a Patient with Combined Inherited Factor VII and Factor X Deficiency due to Accidental Ingestion of a Diphacinone Rodenticide.
    Clin Lab 2016 Nov;62(11):2253-2256
    Background: To explore the characteristics of laboratory examination and confirm the diagnosis of a patient with combined inherited FVII and FX deficiency after he ingested diphacinone rodenticide accidentally.

    Methods: The coagulant parameter screening tests and coagulation factor activities were tested many times in the patient due to accidental ingestion of a diphacinone rodenticide. After the patient was treated for more than one year, gene analysis of correlated coagulation factors was analyzed in the patient and other family members by DNA direct sequencing. Read More

    Parental Refusal of Vitamin K and Neonatal Preventive Services: A Need for Surveillance.
    Matern Child Health J 2017 May;21(5):1079-1084
    Centers for Disease Control and Prevention, Division of Blood Disorders, National Center on Birth Defects and Developmental Disabilities, Atlanta, GA, USA.
    Objectives Vitamin K deficiency bleeding (VKDB) in infants is a coagulopathy preventable with a single dose of injectable vitamin K at birth. The Tennessee Department of Health (TDH) and Centers for Disease Control and Prevention (CDC) investigated vitamin K refusal among parents in 2013 after learning of four cases of VKDB associated with prophylaxis refusal. Methods Chart reviews were conducted at Nashville-area hospitals for 2011-2013 and Tennessee birthing centers for 2013 to identify parents who had refused injectable vitamin K for their infants. Read More

    Vitamin K-Dependent Carboxylation of Matrix Gla Protein Influences the Risk of Calciphylaxis.
    J Am Soc Nephrol 2017 Jun 3;28(6):1717-1722. Epub 2017 Jan 3.
    Cardiology, and.
    Matrix Gla protein (MGP) is a potent inhibitor of vascular calcification. The ability of MGP to inhibit calcification requires the activity of a vitamin K-dependent enzyme, which mediates MGP carboxylation. We investigated how MGP carboxylation influences the risk of calciphylaxis in adult patients receiving dialysis and examined the effects of vitamin K deficiency on MGP carboxylation. Read More

    Synthesis of 2-methyl-1,4-naphthoquinones with higher gamma-glutamyl carboxylase activity than MK-4 both in vitro and in vivo.
    Bioorg Med Chem Lett 2017 Jan 25;27(2):208-211. Epub 2016 Nov 25.
    R&D Group VitaK, Maastricht University, Oxfordlaan 70, 6229 EV Maastricht, The Netherlands.
    Vitamin K is the collective term for compounds that share a 2-methyl-1,4-naphthoquinone ring, but differ in the side-chain at the 3-position. We synthesized novel 2-methyl-1,4-naphthoquinone derivatives with different side chain length at the 3-position. Derivatives with C-14 and C-16 tails showed the highest in vitro bioactivity resulting in 2. Read More

    Correlations of Plasma Desphosphorylated Uncarboxylated Matrix Gla Protein with Vascular Calcification and Vascular Stiffness in Chronic Kidney Disease.
    Nephron 2017 13;135(3):167-172. Epub 2016 Dec 13.
    Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
    Background: Matrix Gla protein (MGP) is a potent inhibitor of vascular calcification and needs vitamin K-dependent carboxylation for its activity. High levels of desphosphorylated uncarboxylated MGP (dp-ucMGP) were significantly associated with vitamin K deficiency and vascular calcification. This study was conducted to explore the correlations of plasma dp-ucMGP with vascular calcification and vascular stiffness in chronic kidney disease (CKD) patients. Read More

    Newborn vitamin K prophylaxis: an analysis of information resources for parents and professionals.
    N Z Med J 2016 Dec 2;129(1446):44-52. Epub 2016 Dec 2.
    Bioethics Centre, University of Otago, Dunedin.
    Aims: Vitamin K prophylaxis represents one of the first healthcare decisions families make for their newborn. Information resources are an important component of this process. This study aimed to identify and analyse written information about vitamin K. Read More

    Vitamin K supplementation to prevent hemorrhagic morbidity and mortality of newborns in India and China.
    World J Pediatr 2017 Feb 15;13(1):15-19. Epub 2016 Nov 15.
    Braun School Public Health and Community Medicine, Hebrew University-Hadassah, Ein Karem, Jerusalem, Israel.
    Background: Vitamin K deficiency bleeding (VKDB) can cause prolonged and bleeding (intracranial hemorrhage) among newborns, which can be life-threatening or lead to long-term morbidity. The aim of this review article is to reiterate empirical evidence to support the argument that vitamin K should be mandatory for newborns in India and China, as well as in other countries with a high burden of neonatal deaths.

    Data Sources: Studies were integrated from the PubMed/MEDLINE database search, as well as related literature available elsewhere. Read More

    Vitamin K Metabolism in a Rat Model of Chronic Kidney Disease.
    Am J Nephrol 2017 16;45(1):4-13. Epub 2016 Nov 16.
    Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ont., Canada.
    Background: Patients with chronic kidney disease (CKD) have very high levels of uncarboxylated, inactive, extra-hepatic vitamin K-dependent proteins measured in circulation, putting them at risk for complications of vitamin K deficiency. The major form of vitamin K found in the liver is phylloquinone (K1). Menaquinone-4 (MK-4) is the form of vitamin K that is preferentially found in extra-hepatic tissues. Read More

    VKCFD2 - from clinical phenotype to molecular mechanism.
    Hamostaseologie 2016 Nov;36(Suppl. 2):S13-S20
    Prof. Dr. med. Johannes Oldenburg, Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany, Tel. +49/(0)228/28  71 51-75 or -76, Fax +49/(0)228/28 71-60 87 or -47 83, Email:
    Vitamin K 2,3-epoxide reductase complex, subunit 1 (VKORC1) is an enzyme essential for the vitamin K cycle. VKORC1 catalyses the reduction of vitamin K 2,3-epoxide to the quinone form of vitamin K and further to vitamin K hydroquinone. The generated vitamin K hydroquinone serves as substrate for the enzyme γ-glutamyl-carboxylase which modifies all vitamin K-dependent proteins, allowing them to bind calcium ions necessary for physiological activity. Read More

    Bleeding and liver transplantation outcomes in haemophilia.
    Haemophilia 2017 Mar 4;23(2):230-237. Epub 2016 Nov 4.
    Hemophilia Center of Western Pennsylvania, Pittsburgh, PA, USA.
    Background: Hepatitis C is the major cause of end-stage liver disease and the major indication for orthotopic liver transplantation (OLTx) in individuals with haemophilia.

    Aim: To assess the epidemiology and outcomes of OLTx in U.S. Read More

    Vitamin-K-Dependent Protection of the Renal Microvasculature: Histopathological Studies in Normal and Diseased Kidneys.
    Pulse (Basel) 2016 Sep 24;4(2-3):85-91. Epub 2016 Aug 24.
    Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium; R & D Group VitaK, Maastricht University, Maastricht, The Netherlands.
    Vitamin-K-dependent carboxylation of matrix Gla protein (MGP) protects the macrocirculation against calcification. We recently reported in a multiethnic population study that the estimated glomerular filtration rate, a microvascular trait, decreased and the risk of chronic kidney disease increased with higher circulating levels of inactive dephospho-uncarboxylated MGP, a marker of vitamin K deficiency. These findings highlighted the possibility that vitamin K might have a beneficial effect on the renal microcirculation. Read More

    Vitamin K homologs as potential biomarkers for disease activity in patients with rheumatoid arthritis.
    J Bone Miner Metab 2016 Oct 8. Epub 2016 Oct 8.
    Department of Rheumatology, King Fahd Hospital, Al Madinah AlMunawarah, Saudi Arabia.
    The aim of this study was to evaluate the possible role of vitamin K homologs as potential biomarkers for disease activity in patients with rheumatoid arthritis (RA). In this study, 42 patients with RA and 40 healthy controls were enrolled. Serum levels of vitamin K homologs were measured using a high-performance liquid chromatography-fluorescence method. Read More

    Deficiency of fat-soluble vitamins in chronic pancreatitis: A systematic review and meta-analysis.
    Pancreatology 2016 Nov - Dec;16(6):988-994. Epub 2016 Sep 20.
    Digestive & Liver Disease Unit, S. Andrea Hospital, University "Sapienza", Rome, Italy. Electronic address:
    Background And Aims: Chronic pancreatitis (CP) patients are at risk for fat-soluble vitamins (A, D, E, K) deficiency, but available studies are small and heterogeneous. We conducted a systematic review and meta-analysis to determine the prevalence of fat-soluble vitamins deficiency in CP patients.

    Methods: Medline was searched up to January 2016 for case series and case-control studies reporting prevalence of fat-soluble vitamin deficiency in CP patients. Read More

    Neonatal Prophylaxis: Prevention of Vitamin K Deficiency Haemorrhage and Neonatal Ophthalmia.
    Zdr Varst 2015 Sep 9;54(3):184-93. Epub 2015 Jun 9.
    University of Ljubljana, Faculty of Health Sciences, Zdravstvena pot 1, 1000 Ljubljana, Slovenia.
    Introduction: The aim of the study was to explore two aspects of neonatal prophylaxis: the application of the vitamin K injection to the newborns and the prophylaxis against chlamydial and gonococcal eye infections, comparing Slovenian and Croatian practices.

    Methods: A causal non-experimental method of quantitative empirical approach was used. The data was collected by means of predesigned questionnaires. Read More

    Intraperitoneal Hemorrhage in a Pregnant Woman with Hyperemesis Gravidarum: Vitamin K Deficiency as a Possible Cause.
    Case Rep Obstet Gynecol 2016 11;2016:5384943. Epub 2016 Aug 11.
    Department of Obstetrics and Gynecology, Jichi Medical University, Tochigi 09216, Japan.
    Hyperemesis gravidarum can cause various vitamin deficiencies. Vitamin K deficiency can lead to coagulopathy or hemorrhagic diathesis. A nulliparous Japanese woman with hyperemesis gravidarum at 10(5/7) weeks was admitted with giant myoma, intestinal obstruction, and abdominal pain. Read More

    Seasonal variation in the international normalized ratio of neonates and its relationship with ambient temperature.
    BMC Pediatr 2016 Jul 19;16:97. Epub 2016 Jul 19.
    Department of Regional Neonatal-Perinatal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.
    Background: The morbidity and mortality rates due to cardiovascular events such as myocardial infarction are known to exhibit seasonal variations. Moreover, changes in the ambient temperature are reportedly associated with an increase in these events, which may potentially involve blood coagulation markers. Bleeding due to vitamin K deficiency in neonates, which is associated with high mortality and a high frequency of neurological sequelae, is more commonly observed during the summer season and in warm regions in Japan. Read More

    Prevention of Vitamin K Deficiency Bleeding.
    J Midwifery Womens Health 2016 Jul 7. Epub 2016 Jul 7.
    The risk that a newborn will develop vitamin K deficiency bleeding is 1700/100,000 (one out of 59) if vitamin K is not administered. When intramuscular vitamin K is administered, the risk of vitamin K deficiency bleeding is reduced to 1/100,000. While women may have misconceptions about vitamin K prophylaxis for their newborns, health care providers should be prepared with factual information. Read More

    Tissue Concentrations of Vitamin K and Expression of Key Enzymes of Vitamin K Metabolism Are Influenced by Sex and Diet but Not Housing in C57Bl6 Mice.
    J Nutr 2016 Aug 6;146(8):1521-7. Epub 2016 Jul 6.
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA;
    Background: There has been limited characterization of biological variables that impact vitamin K metabolism. This gap in knowledge can limit the translation of data obtained from preclinical animal studies to future human studies.

    Objective: The purpose of this study was to determine the effects of diet, sex, and housing on serum, tissue, and fecal vitamin K concentrations and gene expression in C57BL6 mice during dietary vitamin K manipulation. Read More

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