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    2378 results match your criteria Vitamin K Deficiency

    1 OF 48

    The Coags Uncomplicated App: Fulfilling Educational Gaps Around Diagnosis and Laboratory Testing of Coagulation Disorders.
    JMIR Med Educ 2017 Apr 18;3(1):e6. Epub 2017 Apr 18.
    Novo Nordisk Inc., Plainsboro, NJ, United States.
    Background: Patients with coagulation disorders may present to a variety of physician specialties; however, accurate and efficient diagnosis can be challenging for physicians not specialized in hematology, due to identified gaps in knowledge around appropriate laboratory assays and interpretation of test results. Coags Uncomplicated was developed to fill this unmet educational need by increasing practical knowledge of coagulation disorders among nonexpert physicians and other health care professionals (HCPs) in a point-of-care (POC) setting.

    Objective: The aim of this study was to assess patterns of use of the mobile app Coags Uncomplicated, a tool designed to support education regarding accurate and efficient diagnosis of bleeding disorders. Read More

    Finding the optimal dose of vitamin K1 to treat vitamin K deficiency and to avoid anaphylactoid reactions.
    Fundam Clin Pharmacol 2017 Apr 13. Epub 2017 Apr 13.
    Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
    Vitamin K1 injection induces severe dose-related anaphylactoid reactions and overdose for the treatment of vitamin K deficiency. We aimed to find an optimal and small dose of vitamin K1 injection to treat vitamin K deficiency and avoid anaphylactoid reactions in animal. Rats were administered a vitamin K-deficient diet and gentamicin to establish vitamin K deficiency model. Read More

    Calciphylaxis.
    Curr Opin Nephrol Hypertens 2017 Apr 1. Epub 2017 Apr 1.
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
    Purpose Of Review: Calciphylaxis remains a poorly understood vascular calcification disorder with predilection for patients with end-stage renal disease (ESRD). Recent data from large patient registries and databases have begun to provide information regarding incidence, risk factors, and outcomes in patients with calciphylaxis.

    Recent Findings: The most recent estimate places the incidence of calciphylaxis at 3. Read More

    Detection of subclinical vitamin K deficiency in neurosurgery with PIVKA-II.
    Scand J Clin Lab Invest 2017 Mar 20:1-8. Epub 2017 Mar 20.
    a Department of Anaesthesia and Intensive Care, Institution of Clinical Science Lund, Medical Faculty , Lund University , Lund , Sweden.
    Vitamin K is known for supporting the carboxylation of hepatic coagulation proteins. Levels of proteins induced by vitamin K absence for factor II (PIVKA-II) reflect hypocarboxylated prothrombin and can be used to detect subclinical vitamin K deficiency. The aim of this study was to determine the prevalence of perioperative subclinical vitamin K deficiency among neurosurgical patients using PIVKA-II and investigate the existence of any correlation to standard coagulation assays. Read More

    The Strategy to Prevent and Regress the Vascular Calcification in Dialysis Patients.
    Biomed Res Int 2017 14;2017:9035193. Epub 2017 Feb 14.
    Division of Nephrology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Department of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan.
    The high prevalence of arterial calcification in end-stage renal disease (ESRD) is far beyond the explanation by common cardiovascular risk factors such as aging, diabetes, hypertension, and dyslipidemia. The finding relies on the fact that vascular and valvular calcifications are predictors of cardiovascular diseases and mortality in persons with chronic renal failure. In addition to traditional cardiovascular risk factors such as diabetes mellitus and blood pressure control, other ESRD-related risks such as phosphate retention, excess calcium, and prolonged dialysis time also contribute to the development of vascular calcification. Read More

    Susceptiveness of Vitamin K epOxide Reductase Complex Subunit 1 Gene Polymorphism in Essential Hypertension.
    Genet Test Mol Biomarkers 2017 Mar 10. Epub 2017 Mar 10.
    1 Department of Medical Biology, Faculty of Medicine, Eskisehir Osmangazi University , Eskisehir, Turkey .
    Background: Essential hypertension (EH) is defined as worldwide public health problem and one of the important risk factors for development of human coronary artery disease. Increased peripheral arterial resistance is one of the distinguishing characteristics of EH. The extracellular deposition of calcium in the arterial wall is defined as vascular calcification, which results in aortic stiffness and elevation of blood pressure. Read More

    Effectiveness of prothrombin complex concentrate (PCC) in neonates and infants with bleeding or risk of bleeding: a systematic review and meta-analysis.
    Eur J Pediatr 2017 Mar 9. Epub 2017 Mar 9.
    Department of Neonatology, West China Second University Hospital, Sichuan University, Chengdu, China.
    To systematically evaluate the effectiveness of prothrombin complex concentrate (PCC) in neonates and infants, we performed a systematic review and meta-analysis based on current evidence. Quality of studies was assessed by Cochrane Collaboration's risk of bias tool and Newcastle-Ottawa quality assessment scale. For dichotomous data, we obtained the number of events and total number and calculated the relative risk (RR) with 95% confidence intervals (CI). Read More

    Vitamin K Deficiency Presenting in an Infant with an Anterior Mediastinal Mass: A Case Report and Review of the Literature.
    Case Rep Pediatr 2017 9;2017:7628946. Epub 2017 Feb 9.
    School of Medicine, University of Colorado, Boulder, CO, USA.
    We report a case of a 1-month-old infant with spontaneous thymic hemorrhage secondary to severe vitamin K deficiency. He was brought to medical attention due to scrotal bruising and during evaluation was noted to be tachypneic and hypoxemic. Chest X-ray revealed an enlarged cardiothymic silhouette, and a follow-up echocardiogram revealed a mass in the anterior mediastinum. Read More

    Refusal of Vitamin K by Parents of Newborns: A Survey of the Better Outcomes Through Research for Newborns Network.
    Acad Pediatr 2017 Mar 9. Epub 2017 Mar 9.
    Department of Pediatrics, Yale University, New Haven, Conn.
    Objective: To survey newborn clinicians in the United States regarding the frequency of intramuscular (IM) vitamin K refusal by a parent, reasons for refusal, and approaches of clinicians to refusals.

    Methods: An electronic survey was administered to the clinician site representative (nursery director or designee knowledgeable about site-specific nursery policies) at all newborn nurseries in the Better Outcomes through Research for Newborns (BORN) network of newborn nurseries.

    Results: Of 92 BORN sites, 85 (92%) respondents completed the survey. Read More

    The Presentation of a Fussy Infant With Bruising: Late-Onset Vitamin K Deficiency Bleeding.
    Pediatr Emerg Care 2017 Feb 21. Epub 2017 Feb 21.
    From the *Department of Pediatrics and †Division of Pediatric Emergency Medicine, University of Utah, Salt Lake City, UT.
    Vitamin K plays an integral role in the clotting cascade. Deficiency, specifically in vulnerable neonates with insufficient stores, can lead to spontaneous bleeding and devastating effects. In this case, we report a young infant with late-onset vitamin K deficiency bleeding who did not receive vitamin K prophylaxis after birth. Read More

    Vitamin K status in cystic fibrosis patients with liver cirrhosis.
    Dig Liver Dis 2017 Jan 23. Epub 2017 Jan 23.
    Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznan, Poland. Electronic address:
    The available data on the influence of liver cirrhosis on vitamin K status in CF patients is scarce. Therefore, the aims of the present study were to assess the prevalence of vitamin K deficiency in cirrhotic CF subjects and to determine whether it correlates with liver cirrhosis. The study group comprised of 27 CF patients with and 63 without liver cirrhosis. Read More

    Diagnostic Error of a Patient with Combined Inherited Factor VII and Factor X Deficiency due to Accidental Ingestion of a Diphacinone Rodenticide.
    Clin Lab 2016 Nov;62(11):2253-2256
    Background: To explore the characteristics of laboratory examination and confirm the diagnosis of a patient with combined inherited FVII and FX deficiency after he ingested diphacinone rodenticide accidentally.

    Methods: The coagulant parameter screening tests and coagulation factor activities were tested many times in the patient due to accidental ingestion of a diphacinone rodenticide. After the patient was treated for more than one year, gene analysis of correlated coagulation factors was analyzed in the patient and other family members by DNA direct sequencing. Read More

    Parental Refusal of Vitamin K and Neonatal Preventive Services: A Need for Surveillance.
    Matern Child Health J 2017 May;21(5):1079-1084
    Centers for Disease Control and Prevention, Division of Blood Disorders, National Center on Birth Defects and Developmental Disabilities, Atlanta, GA, USA.
    Objectives Vitamin K deficiency bleeding (VKDB) in infants is a coagulopathy preventable with a single dose of injectable vitamin K at birth. The Tennessee Department of Health (TDH) and Centers for Disease Control and Prevention (CDC) investigated vitamin K refusal among parents in 2013 after learning of four cases of VKDB associated with prophylaxis refusal. Methods Chart reviews were conducted at Nashville-area hospitals for 2011-2013 and Tennessee birthing centers for 2013 to identify parents who had refused injectable vitamin K for their infants. Read More

    Vitamin K-Dependent Carboxylation of Matrix Gla Protein Influences the Risk of Calciphylaxis.
    J Am Soc Nephrol 2017 Jan 3. Epub 2017 Jan 3.
    Cardiology, and.
    Matrix Gla protein (MGP) is a potent inhibitor of vascular calcification. The ability of MGP to inhibit calcification requires the activity of a vitamin K-dependent enzyme, which mediates MGP carboxylation. We investigated how MGP carboxylation influences the risk of calciphylaxis in adult patients receiving dialysis and examined the effects of vitamin K deficiency on MGP carboxylation. Read More

    Synthesis of 2-methyl-1,4-naphthoquinones with higher gamma-glutamyl carboxylase activity than MK-4 both in vitro and in vivo.
    Bioorg Med Chem Lett 2017 Jan 25;27(2):208-211. Epub 2016 Nov 25.
    R&D Group VitaK, Maastricht University, Oxfordlaan 70, 6229 EV Maastricht, The Netherlands.
    Vitamin K is the collective term for compounds that share a 2-methyl-1,4-naphthoquinone ring, but differ in the side-chain at the 3-position. We synthesized novel 2-methyl-1,4-naphthoquinone derivatives with different side chain length at the 3-position. Derivatives with C-14 and C-16 tails showed the highest in vitro bioactivity resulting in 2. Read More

    Correlations of Plasma Desphosphorylated Uncarboxylated Matrix Gla Protein with Vascular Calcification and Vascular Stiffness in Chronic Kidney Disease.
    Nephron 2017 13;135(3):167-172. Epub 2016 Dec 13.
    Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
    Background: Matrix Gla protein (MGP) is a potent inhibitor of vascular calcification and needs vitamin K-dependent carboxylation for its activity. High levels of desphosphorylated uncarboxylated MGP (dp-ucMGP) were significantly associated with vitamin K deficiency and vascular calcification. This study was conducted to explore the correlations of plasma dp-ucMGP with vascular calcification and vascular stiffness in chronic kidney disease (CKD) patients. Read More

    Newborn vitamin K prophylaxis: an analysis of information resources for parents and professionals.
    N Z Med J 2016 Dec 2;129(1446):44-52. Epub 2016 Dec 2.
    Bioethics Centre, University of Otago, Dunedin.
    Aims: Vitamin K prophylaxis represents one of the first healthcare decisions families make for their newborn. Information resources are an important component of this process. This study aimed to identify and analyse written information about vitamin K. Read More

    Vitamin K supplementation to prevent hemorrhagic morbidity and mortality of newborns in India and China.
    World J Pediatr 2017 Feb 15;13(1):15-19. Epub 2016 Nov 15.
    Braun School Public Health and Community Medicine, Hebrew University-Hadassah, Ein Karem, Jerusalem, Israel.
    Background: Vitamin K deficiency bleeding (VKDB) can cause prolonged and bleeding (intracranial hemorrhage) among newborns, which can be life-threatening or lead to long-term morbidity. The aim of this review article is to reiterate empirical evidence to support the argument that vitamin K should be mandatory for newborns in India and China, as well as in other countries with a high burden of neonatal deaths.

    Data Sources: Studies were integrated from the PubMed/MEDLINE database search, as well as related literature available elsewhere. Read More

    Vitamin K Metabolism in a Rat Model of Chronic Kidney Disease.
    Am J Nephrol 2017 16;45(1):4-13. Epub 2016 Nov 16.
    Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ont., Canada.
    Background: Patients with chronic kidney disease (CKD) have very high levels of uncarboxylated, inactive, extra-hepatic vitamin K-dependent proteins measured in circulation, putting them at risk for complications of vitamin K deficiency. The major form of vitamin K found in the liver is phylloquinone (K1). Menaquinone-4 (MK-4) is the form of vitamin K that is preferentially found in extra-hepatic tissues. Read More

    Bleeding and liver transplantation outcomes in haemophilia.
    Haemophilia 2017 Mar 4;23(2):230-237. Epub 2016 Nov 4.
    Hemophilia Center of Western Pennsylvania, Pittsburgh, PA, USA.
    Background: Hepatitis C is the major cause of end-stage liver disease and the major indication for orthotopic liver transplantation (OLTx) in individuals with haemophilia.

    Aim: To assess the epidemiology and outcomes of OLTx in U.S. Read More

    Vitamin-K-Dependent Protection of the Renal Microvasculature: Histopathological Studies in Normal and Diseased Kidneys.
    Pulse (Basel) 2016 Sep 24;4(2-3):85-91. Epub 2016 Aug 24.
    Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium; R & D Group VitaK, Maastricht University, Maastricht, The Netherlands.
    Vitamin-K-dependent carboxylation of matrix Gla protein (MGP) protects the macrocirculation against calcification. We recently reported in a multiethnic population study that the estimated glomerular filtration rate, a microvascular trait, decreased and the risk of chronic kidney disease increased with higher circulating levels of inactive dephospho-uncarboxylated MGP, a marker of vitamin K deficiency. These findings highlighted the possibility that vitamin K might have a beneficial effect on the renal microcirculation. Read More

    Vitamin K homologs as potential biomarkers for disease activity in patients with rheumatoid arthritis.
    J Bone Miner Metab 2016 Oct 8. Epub 2016 Oct 8.
    Department of Rheumatology, King Fahd Hospital, Al Madinah AlMunawarah, Saudi Arabia.
    The aim of this study was to evaluate the possible role of vitamin K homologs as potential biomarkers for disease activity in patients with rheumatoid arthritis (RA). In this study, 42 patients with RA and 40 healthy controls were enrolled. Serum levels of vitamin K homologs were measured using a high-performance liquid chromatography-fluorescence method. Read More

    Deficiency of fat-soluble vitamins in chronic pancreatitis: A systematic review and meta-analysis.
    Pancreatology 2016 Nov - Dec;16(6):988-994. Epub 2016 Sep 20.
    Digestive & Liver Disease Unit, S. Andrea Hospital, University "Sapienza", Rome, Italy. Electronic address:
    Background And Aims: Chronic pancreatitis (CP) patients are at risk for fat-soluble vitamins (A, D, E, K) deficiency, but available studies are small and heterogeneous. We conducted a systematic review and meta-analysis to determine the prevalence of fat-soluble vitamins deficiency in CP patients.

    Methods: Medline was searched up to January 2016 for case series and case-control studies reporting prevalence of fat-soluble vitamin deficiency in CP patients. Read More

    Neonatal Prophylaxis: Prevention of Vitamin K Deficiency Haemorrhage and Neonatal Ophthalmia.
    Zdr Varst 2015 Sep 9;54(3):184-93. Epub 2015 Jun 9.
    University of Ljubljana, Faculty of Health Sciences, Zdravstvena pot 1, 1000 Ljubljana, Slovenia.
    Introduction: The aim of the study was to explore two aspects of neonatal prophylaxis: the application of the vitamin K injection to the newborns and the prophylaxis against chlamydial and gonococcal eye infections, comparing Slovenian and Croatian practices.

    Methods: A causal non-experimental method of quantitative empirical approach was used. The data was collected by means of predesigned questionnaires. Read More

    Intraperitoneal Hemorrhage in a Pregnant Woman with Hyperemesis Gravidarum: Vitamin K Deficiency as a Possible Cause.
    Case Rep Obstet Gynecol 2016 11;2016:5384943. Epub 2016 Aug 11.
    Department of Obstetrics and Gynecology, Jichi Medical University, Tochigi 09216, Japan.
    Hyperemesis gravidarum can cause various vitamin deficiencies. Vitamin K deficiency can lead to coagulopathy or hemorrhagic diathesis. A nulliparous Japanese woman with hyperemesis gravidarum at 10(5/7) weeks was admitted with giant myoma, intestinal obstruction, and abdominal pain. Read More

    Seasonal variation in the international normalized ratio of neonates and its relationship with ambient temperature.
    BMC Pediatr 2016 Jul 19;16:97. Epub 2016 Jul 19.
    Department of Regional Neonatal-Perinatal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.
    Background: The morbidity and mortality rates due to cardiovascular events such as myocardial infarction are known to exhibit seasonal variations. Moreover, changes in the ambient temperature are reportedly associated with an increase in these events, which may potentially involve blood coagulation markers. Bleeding due to vitamin K deficiency in neonates, which is associated with high mortality and a high frequency of neurological sequelae, is more commonly observed during the summer season and in warm regions in Japan. Read More

    Prevention of Vitamin K Deficiency Bleeding.
    J Midwifery Womens Health 2016 Jul 7. Epub 2016 Jul 7.
    The risk that a newborn will develop vitamin K deficiency bleeding is 1700/100,000 (one out of 59) if vitamin K is not administered. When intramuscular vitamin K is administered, the risk of vitamin K deficiency bleeding is reduced to 1/100,000. While women may have misconceptions about vitamin K prophylaxis for their newborns, health care providers should be prepared with factual information. Read More

    A Blown Pupil and Intracranial Hemorrhage in a 4-Week-Old: A Case of Delayed Onset Vitamin K Deficiency Bleeding, a Rare "Can't Miss" Diagnosis.
    J Emerg Med 2016 Aug 11;51(2):164-7. Epub 2016 Jun 11.
    Department of Emergency Medicine, Maine Medical Center, Portland, Maine.
    Background: Infants are at risk for vitamin K deficiency bleeding (VKDB) because of limited stores of vitamin K (VK) at birth and a low concentration of VK in human breast milk. Therefore, the administration of intramuscular (IM) VK at birth has been recommended since 1961 in the United States. Infants who do not receive IM VK and who are exclusively breast-fed are at increased risk for VKDB. Read More

    Gastrointestinal bleeding secondary to trimethoprim-sulfamethoxazole-induced vitamin K deficiency.
    BMJ Case Rep 2016 Jun 6;2016. Epub 2016 Jun 6.
    Department of Internal Medicine, University of Arizona Medical Center-University Campus, Tucson, Arizona, USA.
    There is a well-known association between vitamin K deficiency and haemorrhagic events including gastrointestinal bleeding. There is also a well-known association between both poor dietary intake of vitamin K and chronic antibiotic use and the development of vitamin K deficiency. Although the medical literature notes that cephalosporin antibiotics have a propensity to cause vitamin K deficiency due to the molecular structure of the medications and their ability to suppress the synthesis of clotting factors, there are other antibiotics that have also been implicated in the development of vitamin K deficiency. Read More

    Establishing a rat model for the study of vitamin K deficiency.
    Int J Exp Pathol 2016 Apr 3;97(2):187-93. Epub 2016 Jun 3.
    Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
    The main vitamin K-deficient model, minidose warfarin, is different from the pathological mechanism of vitamin K deficiency, which is a shortage of vitamin K. The objective of this study was to establish a new method of vitamin K-deficient model combining a vitamin K-deficient diet with the intragastrical administration of gentamicin in rats. The clotting was assayed by an automated coagulation analyser. Read More

    The role of vitamin K in vascular calcification of patients with chronic kidney disease.
    Acta Clin Belg 2016 Dec 25;71(6):462-467. Epub 2016 May 25.
    a Department of Internal Medicine, Renal Division , Ghent University Hospital , Ghent , Belgium.
    Patients with chronic kidney disease (CKD) are prone to vascular calcification. Pathogenetic mechanisms of vascular calcifications have been broadly studied and discussed such as the role of hyperphosphatemia, hypercalcemia, parathormone, and vitamin D. In recent years, new insights have been gained pointing to vitamin K as a main actor. Read More

    Prophylactic Dosing of Vitamin K to Prevent Bleeding.
    Pediatrics 2016 May;137(5)
    Pediatric Gastroenterology and Hepatology, Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; and
    Background And Objectives: Based on a high incidence of Vitamin K deficiency bleeding (VKDB) in breastfed infants with thus far unrecognized cholestasis, such as biliary atresia (BA), the Dutch regimen to prevent VKDB in breastfed infants was changed from a daily oral dosage of 25 µg to 150 µg vitamin K. Infants continued to receive 1 mg of vitamin K orally at birth. We compared the efficacy of the 150-µg regimen with the 25-µg regimen and with the Danish regimen of a single intramuscular (IM) dose of 2 mg vitamin K at birth. Read More

    Low vitamin K1 intake in haemodialysis patients.
    Clin Nutr 2017 Apr 28;36(2):601-607. Epub 2016 Apr 28.
    Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
    Background & Aims: Vitamin K acts as a coenzyme in the γ-carboxylation of vitamin K-dependent proteins, including coagulation factors, osteocalcin, matrix Gla protein (MGP), and the growth arrest-specific 6 (GAS6) protein. Osteocalcin is a key factor for bone matrix formation. MGP is a local inhibitor of soft tissue calcification. Read More

    Changes in fat-soluble vitamin levels after gastrectomy for gastric cancer.
    Surg Today 2017 Feb 25;47(2):145-150. Epub 2016 May 25.
    Department of Surgery, School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
    Several authors have reported the relationship between gastric cancer risk and vitamins. However, there are few reports on fat-soluble vitamins after gastrectomy for gastric cancer. Fat malabsorption and suppression of food intake after gastrectomy for gastric cancer have been previously documented. Read More

    PIVKA-II correlates with INR but not protein C or protein S concentrations in cord blood among newborns.
    J Neonatal Perinatal Med 2016 May;9(2):139-43
    Baylor College of Medicine, Houston, TX, USA.
    Background: Protein induced by vitamin K absence (PIVKA)-II, inactive precursor of prothrombin, is elevated in vitamin K (VK) deficiency. Our aims were to find the prevalence of VK deficiency in neonates, assess the utility of international normalized ratio (INR) as a screening tool, and explore the relationship between PIVKA-II, activated partial thromboplastin time (aPTT) and VK dependent anticoagulants.

    Methods: INR, aPTT, PIVKA-II, and proteins C and S activities were measured in neonatal cord blood prior to VK administration. Read More

    [Serious Coagulation Dysfunction in a Patient with Gallstone-related Cholecystitis Successfully Treated with Vitamin K].
    Masui 2016 Apr;65(4):407-10
    An 85-year-old woman with a diagnosis of choledocholithiasis due to common duct stones gradually developed severe coagulation dysfunction over the course of 27 days after hospitalization. Initial clinical findings were fever, general malaise, and obstructive jaundice. She was treated with fasting, and received cephem antibiotics containing N-methyl-thio-tetrazole. Read More

    Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review.
    J Perinatol 2016 May;36 Suppl 1:S29-35
    Newborn Health Knowledge Centre (NHKC), ICMR Center for Advanced Research in Newborn Health, WHO Collaborating Centre for Training and Research in Newborn Care, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
    We conducted a systematic review to evaluate the burden of late vitamin K deficiency bleeding (VKDB) and the effect of vitamin K prophylaxis on the incidence of VKDB. We searched MEDLINE and other electronic databases, and included all observational studies including population surveys as well as randomized controlled trials (RCT). The median (interquartile range) burden of late VKDB was 35 (10. Read More

    Prevention of Vitamin K Deficiency Bleeding in Newborn Infants: A Position Paper by the ESPGHAN Committee on Nutrition.
    J Pediatr Gastroenterol Nutr 2016 Jul;63(1):123-9
    *Department of Pediatrics, Harlaching, Munich Municipal Hospitals, Munich, Germany†Department of Pediatric Gastroenterology, University Children's Hospital, Zurich, Switzerland‡Department Pediatrics, University Hospital Motol, Prague, Czech Republic§Department of Pediatrics, University of Granada, Granada, Spain||Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden¶Childhood Nutrition Research Centre, UCL Institute of Child Health, London, UK#Department of Gastroenterology, Hepatology and Nutrition, University Children's Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia**University Children's Hospital Zagreb, Zagreb, Croatia††Department of Pediatrics, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands‡‡Department of Pediatrics, University Hospital Giovanni XXIII, University Aldo Moro, Bari, Italy§§APHP Necker-Enfants Malades Hospital, Paris Descartes University, Paris, France||||CNRC, Baylor College of Medicine, Houston, TX¶¶Department of Nutrition, Exercise and Sports, University of Copenhagen, K⊘benhavn##Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark***Newcastle Neonatal Service, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK†††Department of Pediatrics, VU University Medical Center‡‡‡Department of Pediatrics, Emma Children's Hospital-AMC, Amsterdam, The Netherlands.
    Vitamin K deficiency bleeding (VKDB) due to physiologically low vitamin K plasma concentrations is a serious risk for newborn and young infants and can be largely prevented by adequate vitamin K supplementation. The aim of this position paper is to define the condition, describe the prevalence, discuss current prophylaxis practices and outcomes, and to provide recommendations for the prevention of VKDB in healthy term newborns and infants. All newborn infants should receive vitamin K prophylaxis and the date, dose, and mode of administration should be documented. Read More

    Functional deficiency of vitamin K in hemodialysis patients in Upper Silesia in Poland.
    Int Urol Nephrol 2016 May 21;48(5):765-71. Epub 2016 Mar 21.
    Department of Pathophysiology, Medical Faculty in Katowice, Medical University of Silesia, Medyków 18 Street, 40-752, Katowice, Poland.
    Purpose: Functional vitamin K deficiency (both K1 and K2) is postulated to be one of the most relevant links between chronic kidney disease and vascular calcification in hemodialysis (HD) patients. Recommended dietary restrictions in HD patients superimposed on diversity of eating habits across the countries may affect the prevalence of functional vitamin K deficiency. The aim of this study was to determine the level of functional vitamin K deficiency and its relation to vitamin K1 intake in HD patients in Upper Silesia in Poland. Read More

    Effectiveness of a computerized decision support system for anticoagulation management in hemodialysis patients: A before-after study.
    Hemodial Int 2016 Oct 17;20(4):530-536. Epub 2016 Mar 17.
    Division of Nephrology, Department of Medicine and Kidney Research Centre, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada.
    Introduction The risk-benefit profile for warfarin anticoagulation in hemodialysis (HD) patients differs compared with the non-HD population. HD patients are at increased risk of both thromboembolism and bleeding related to anticoagulation therapy. In addition, anticoagulation control may be more difficult to achieve in the HD population due to frequent comorbidities, subclinical Vitamin K deficiency, altered pharmacokinetics due to uremia and the concurrent use of multiple medications. Read More

    The effects of vitamin K supplementation and vitamin K antagonists on progression of vascular calcification: ongoing randomized controlled trials.
    Clin Kidney J 2016 Apr 29;9(2):273-9. Epub 2015 Dec 29.
    Division of Nephrology and Infectious Diseases , AZ Sint-Jan Brugge , Brugge , Belgium.
    Background: The extent and the progression of vascular calcification (VC) are independent predictors of cardiovascular risk in the haemodialysis population. Vitamin K is essential for the activation of matrix gla protein (MGP), a powerful inhibitor of tissue calcification. Functional vitamin K deficiency may contribute to the high VC burden in haemodialysis patients. Read More

    Biological Systems of Vitamin K: A Plasma Nutriproteomics Study of Subclinical Vitamin K Deficiency in 500 Nepalese Children.
    OMICS 2016 Apr 25;20(4):214-23. Epub 2016 Feb 25.
    1 Center for Human Nutrition, Departments of International Health, Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland.
    Vitamin K (VK) is a fat-soluble vitamin whose deficiency disrupts coagulation and may disturb bone and cardiovascular health. However, the scale and systems affected by VK deficiency in pediatric populations remains unclear. We conducted a study of the plasma proteome of 500 Nepalese children 6-8 years of age (male/female ratio = 0. Read More

    Management of vitamin K deficiency after biliopancreatic diversion with or without duodenal switch.
    Surg Obes Relat Dis 2016 Feb 1;12(2):338-44. Epub 2015 Oct 1.
    Department of Internal Medicine, Rijnstate Hospital, Arnhem, The Netherlands.
    Background: Reduced serum vitamin K levels are frequently observed after biliopancreatic diversion (BPD) and BPD with duodenal switch (BPD/DS). The criteria for treatment are not precisely defined.

    Objectives: To assess the effects of standardized vitamin K supplementation in patients who develop vitamin K deficiency after BPD or BPD/DS. Read More

    Proper Calcium Use: Vitamin K2 as a Promoter of Bone and Cardiovascular Health.
    Integr Med (Encinitas) 2015 Feb;14(1):34-9
    is the president and scientific coordinator of International Science and Health Foundation in Krakow, Poland.
    Inadequate calcium intake can lead to decreased bone mineral density, which can increase the risk of bone fractures. Supplemental calcium promotes bone mineral density and strength and can prevent osteoporosis. Recent scientific evidence, however, suggests that elevated consumption of calcium supplements may raise the risk for heart disease and can be connected with accelerated deposit of calcium in blood-vessel walls and soft tissues. Read More

    Characterization of vitamin K-dependent carboxylase mutations that cause bleeding and nonbleeding disorders.
    Blood 2016 Apr 12;127(15):1847-55. Epub 2016 Jan 12.
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC;
    Vitamin K-dependent coagulation factors deficiency is a bleeding disorder mainly associated with mutations in γ-glutamyl carboxylase (GGCX) that often has fatal outcomes. Some patients with nonbleeding syndromes linked to GGCX mutations, however, show no coagulation abnormalities. The correlation between GGCX genotypes and their clinical phenotypes has been previously unknown. Read More

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