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    2419 results match your criteria Vitamin K Deficiency

    1 OF 49

    Slow Elevation in Protein C Activity without a Mutation in a Neonate with Intracranial Hemorrhage.
    AJP Rep 2018 Apr 12;8(2):e68-e70. Epub 2018 Apr 12.
    Department of Postgraduate Education and Training, National Center for Child Health and Development, Tokyo, Japan.
    Severe protein C (PC) deficiency leads to purpura fulminans and stroke in newborns. However, the clinical impact of plasma PC activity on the development of neonatal cerebral disease remains elusive. We report a case of hemorrhagic stroke associated with neonatal asphyxia and severe PC deficiency. Read More

    Controllable vitamin K deficiency under high-dose oral menatetrenone administration - a case report.
    Pharmazie 2018 Apr;73(4):234-240
    Vitamin (V) K deficiency may cause severe bleeding tendencies, which necessitates extreme caution. We report a case of a 30-year-old man diagnosed with VK deficiency of unknown etiology. He was treated with intravenous menatetrenone three times a week in an outpatient setting for about 1 year and 9 months. Read More

    Estimated costs for treatment and prophylaxis of newborn vitamin K deficiency bleeding in Tashkent, Uzbekistan.
    Nagoya J Med Sci 2018 Feb;80(1):11-20
    Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan.
    Vitamin K deficiency bleeding (VKDB) is a preventable cause of infant mortality and long-term morbidity through the world. This study aimed to demonstrate the costs of VKDB treatment estimated from the hospital records in Tashkent, Uzbekistan, as well as the prophylaxis costs for mass vitamin K medication. Subjects were 50 patients with no operation and 50 patients who had received a brain operation, consecutively enrolled from 180 cases diagnosed at Republican Research Center of Emergency Medicine in 2014. Read More

    Vitamin K deficiency: a case report and review of current guidelines.
    Ital J Pediatr 2018 Mar 14;44(1):36. Epub 2018 Mar 14.
    Pediatric and Infectious Disease Unit, Bambino Gesu' Children's Hospital, IRCCS, Piazza Sant'Onofrio 4, Rome, Italy.
    Background: Vitamin K, a fat soluble vitamin, is a necessary cofactor for the activation of coagulation factors II, VII, IX, X, and protein C and S. In neonatal period, vitamin K deficiency may lead to Vitamin K Deficiency Bleeding (VKDB).

    Case Presentation: We present the case of a 2 months and 20 days Caucasian male, presented for bleeding from the injections sites of vaccines. Read More

    Late-Onset Vitamin K Deficiency Presenting as Scrotal Bruising and Mediastinal Mass.
    Pediatr Emerg Care 2018 Mar 12. Epub 2018 Mar 12.
    Although there are several reports of intracranial hemorrhage associated with vitamin K deficient bleeding, there are few reported cases of extracranial manifestations, specifically involving the thymus. Here, we discuss the unique case of a 4-week-old infant presenting with scrotal discoloration, respiratory distress, and widened mediastinum, found to have thymic hemorrhage related to confirmed coagulopathy secondary to late-onset vitamin K deficiency bleeding of the newborn. Read More

    Pharmacogenetic variants and vitamin K deficiency: a risk factor or trigger for fibrosing interstitial pneumonias?
    Curr Opin Pulm Med 2018 May;24(3):287-295
    Department of Pharmacology and Toxicology, Faculty of Health, Medicine and Life Science, Maastricht University, Maastricht.
    Purpose Of Review: Fibrosing interstitial pneumonias are associated with various stages of fibrosis. The cause of this group of syndromes remains largely unknown. For most of these diseases, a genetic basis, environmental factors and certain triggers have been suggested as possible risk factors. Read More

    Transdermal delivery of vitamin K using dissolving microneedles for the prevention of vitamin K deficiency bleeding.
    Int J Pharm 2018 Apr 19;541(1-2):56-63. Epub 2018 Feb 19.
    School of Pharmacy, Queen's University, Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, United Kingdom. Electronic address:
    Vitamin K deficiency within neonates can result in vitamin K deficiency bleeding. Ensuring that newborns receive vitamin K is particularly critical in places where access to health care and blood products and transfusions is limited. The World Health Organization recommends that newborns receive a 1 mg intramuscular injection of vitamin K at birth. Read More

    Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates.
    Cochrane Database Syst Rev 2018 02 5;2:CD008342. Epub 2018 Feb 5.
    Pediatrics Division of Newborn Medicine, University of Pittsburgh Medical Center, 300 Halket Street, Pittsburgh, Pennsylvania, USA, 15219.
    Background: Vitamin K is necessary for the synthesis of coagulation factors. Term infants, especially those who are exclusively breast fed, are deficient in vitamin K and consequently may have vitamin K deficiency bleeding (VKDB). Preterm infants are potentially at greater risk for VKDB because of delayed feeding and subsequent delay in the colonization of their gastrointestinal system with vitamin K producing microflora, as well as immature hepatic and hemostatic function. Read More

    Nonsurgical management of an extensive spontaneous spinal epidural hematoma causing quadriplegia and respiratory distress in a choledocholithiasis patient: A case report.
    Medicine (Baltimore) 2017 Dec;96(51):e9368
    Rationale: Spontaneous spinal epidural hematoma (SSEH) manifests from blood accumulating in the epidural space, compressing the spinal cord, and leading to acute neurological deficits. The disease's cloudy etiology and rarity contribute to dangerously suboptimal therapeutic principles. These neural deficits can be permanent, even fatal, if the SSEH is not treated in a timely and appropriate manner. Read More

    Rat Poisoning: A Challenging Diagnosis With Clinical and Psychological Implications.
    Lab Med 2018 Jan 22. Epub 2018 Jan 22.
    Division of Laboratory Medicine, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL.
    Rat poisoning should be considered in the differential diagnosis of a patient presenting with signs and symptoms of vitamin K deficiency without a more likely explanation. However, confirming this diagnosis may be difficult due to the varying sensitivities of available assays. A 40-year-old Caucasian woman presented to our hospital with chronic abdominal pain, hematuria, and a history of diarrhea of unknown etiology, despite an extensive work-up. Read More

    Intraventricular Hemorrhage Due to Coagulopathy After Vitamin K Administration in a Preterm Infant With Maternal Crohn Disease.
    Jpn Clin Med 2017 7;8:1179670717746333. Epub 2017 Dec 7.
    Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.
    Intraventricular hemorrhage (IVH) is a devastating morbidity in preterm infants and can result in poor neurodevelopmental outcomes. Intraventricular hemorrhage usually occurs within 72 hours after birth; post-acute-phase IVH (>1 week after birth) is uncommon. Development of the hemostatic system in fetuses and neonates is an age-dependent evolving process, and the neonatal hemostatic system is characterized by low levels of vitamin K-dependent factors, with further reduction caused by prematurity. Read More

    Prevalence of vitamin K deficiency and associated factors in non-supplemented cystic fibrosis patients.
    Arch Argent Pediatr 2018 Feb;116(1):e19-e25
    Allergology Outpatient Department, Provincial Hospital No 2, Rzeszow, Poland.
    Introduction: Vitamin K deficiency is highly prevalent in cystic fibrosis (CF) patients despite supplementation. Moreover, no reliable risk factors for its occurrence are known. The aim was to assess the prevalence of vitamin K deficiency and associated factors in non-supplemented CF patients. Read More

    Negative Impact of Prolonged Antibiotics or Persistent Diarrhea on Vitamin K1 Levels in 2-24 Weeks aged Egyptian Infants.
    Mediterr J Hematol Infect Dis 2018 1;10(1):e2018010. Epub 2018 Jan 1.
    Paediatrics, Faculty of Medicine, Ain Shams University, Egypt.
    Background: To evaluate the hazard of prolonged antibiotic therapy and/or persistent diarrhea on vitamin K1 (VK1) level and bleeding profile in infants (2-24 weeks).

    Methods: A one-year case-control study, conducted at Ain Shams University, Egypt. 338 infants (2-24 weeks) were recruited and divided into 3 groups (1:1:3 ratios); group A (n=67) patients who received antibiotics for ≥10 days, group B (n=67) who had persistent diarrhea ≥ 14 days and group C (n=204) age- and gender- matched infants who had not either received antibiotics nor had diarrhea. Read More

    Clinical relevance of aortic stiffness in end-stage renal disease and diabetes: implication for hypertension management.
    J Hypertens 2018 Jan 2. Epub 2018 Jan 2.
    Paris Descartes University, Faculty of Medicine, AP-HP, Diagnosis and Therapeutics Centre, Hypertension and Cardiovascular Prevention Unit, Hôtel-Dieu Hospital, Paris, France.
    : Evidence suggests that aortic stiffness may antedate and contribute initially to the development of hypertension and cardiovascular risk (CVR). In treated hypertensive patients, both diabetes and end-stage renal disease (ESRD) are comorbid conditions associated with increased aortic stiffness and high CVR. Thus, the pathophysiological relationship between aortic stiffness, blood pressure (BP) and CVR may have clinical implication in the management of hypertension. Read More

    Coagulopathy in Zellweger spectrum disorders: a role for vitamin K.
    J Inherit Metab Dis 2018 Mar 14;41(2):249-255. Epub 2017 Nov 14.
    Department of Pediatric Hematology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands.
    Introduction: Zellweger spectrum disorders (ZSDs) are caused by an impairment of peroxisome biogenesis, resulting in multiple metabolic abnormalities. This leads to a range of symptoms, including hepatic dysfunction and coagulopathy. This study evaluated the incidence and severity of coagulopathy and the effect of vitamin K supplementation orally and IV in ZSD. Read More

    Vitamin K deficiency: the linking pin between COPD and cardiovascular diseases?
    Respir Res 2017 Nov 13;18(1):189. Epub 2017 Nov 13.
    Department of Pulmonary Medicine, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands.
    Cardiovascular diseases are prevalent in patients with chronic obstructive pulmonary disease (COPD). Their coexistence implies that many COPD patients require anticoagulation therapy. Although more and more replaced by direct oral anticoagulants, vitamin K antagonists (VKAs) are still widely used. Read More

    Acquired Vitamin K Deficiency as Unusual Cause of Bleeding Tendency in Adults: A Case Report of a Nonhospitalized Student Presenting with Severe Menorrhagia.
    Case Rep Obstet Gynecol 2017 27;2017:4239148. Epub 2017 Aug 27.
    Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
    We report a rare case of acquired vitamin K deficiency presenting with severe menorrhagia and without any gynecological problem. Partial thromboplastin time (59.2 seconds) and prothrombin time (33. Read More

    Role of Fat-Soluble Vitamins in Osteoarthritis Management.
    J Clin Rheumatol 2018 Apr;24(3):132-137
    Osteoarthritis (OA) is a chronic degenerative joint disease, in which metabolic imbalance in bone is observed. The pathological mechanism of metabolic imbalance is not clear yet, but the nutritional factors, particularly the vitamins, might be intrinsic to the development and progression of OA. In this review article, we have explored databases such as PubMed, Scopus, and Google Scholar articles until the beginning of 2017 and reviewed the role of fat-soluble vitamins in pathological and therapeutic aspects of OA. Read More

    Hypoprothrombinemia and severe perioperative haemorrhagic complications in cardiac surgery patients treated with high-dose cefazolin for infective endocarditis.
    Anaesth Crit Care Pain Med 2018 Apr 1;37(2):167-170. Epub 2017 Sep 1.
    Department of Anaesthesia and Critical Care II, CHU Bordeaux, 33600 Pessac, France; UMR 1034, Inserm, Biology of Cardiovascular Diseases, University Bordeaux, 33600 Pessac, France. Electronic address:
    Endocarditis is a serious and common disease that requires prolonged antimicrobial therapy. The recent shortage of oxacillin has led to the use of other antimicrobial agents such as cefazolin to treat endocarditis due to methicillin-sensitive Staphylococcus aureus. We describe four cases of life-threatening haemorrhagic complications (fatal in two cases) in patients treated with high-dose cefazolin. Read More

    Vitamin K supplementation for cystic fibrosis.
    Cochrane Database Syst Rev 2017 08 22;8:CD008482. Epub 2017 Aug 22.
    Department of Paediatrics, American Mission Hospital, Manama, Manama, Bahrain, PO Box 1.
    Background: Cystic fibrosis is a genetic disorder which can lead to multiorgan dysfunction. Malabsorption of fat and fat-soluble vitamins (A, D, E, K) may occur and can cause subclinical deficiencies of some of these vitamins. Vitamin K is known to play an important role in both blood coagulation and bone formation. Read More

    Vitamin K2 supplementation and arterial stiffness among renal transplant recipients-a single-arm, single-center clinical trial.
    J Am Soc Hypertens 2017 Sep 13;11(9):589-597. Epub 2017 Jul 13.
    Lebanese American University School of Medicine, Byblos, Lebanon; Division of Nephrology and Transplantation, Department of Medicine, Lebanese American University Medical Center-Rizk Hospital, Beirut, Lebanon. Electronic address:
    Subclinical vitamin K deficiency is prevalent among renal transplant recipients and is associated with an increased risk of cardiovascular disease. However, the association between vitamin K supplementation and improvement of arterial stiffness has not been explored in the renal transplant population. The KING trial (vitamin K2 In reNal Graft) is a single-arm study that evaluated the association between the change in vitamin K status and indices of arterial stiffness following 8 weeks of menaquinone-7 (vitamin K2) supplementation (360 μg once daily) among renal transplant recipients (n = 60). Read More

    Chondrodysplasia Punctata: A Case Report of Fetal Warfarin Syndrome.
    J Nepal Health Res Counc 2017 Jan;15(35):81-84
    Department of Radiology and Imaging, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.
    Chondrodysplasia punctata is abnormal calcification in the cartilage of developing bones and has been seen in association with deranged vitamin K metabolism. Warfarin, an oral anticoagulant acting on vitamin K dependent clotting factors is known to cause chondrodysplasia punctata. Despite the knowledge of the condition the management of patients with prosthetic heart valves might require use of the drug for anticoagulation. Read More

    Intrahepatic Cholestasis of Pregnancy Leading to Severe Vitamin K Deficiency and Coagulopathy.
    Case Rep Obstet Gynecol 2017 7;2017:5646247. Epub 2017 Jun 7.
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA.
    Intrahepatic cholestasis of pregnancy is seldom associated with significant vitamin K deficiency. We report a case of a 16-year-old primigravid patient at 24 weeks and 3 days of gestation who presented with pruritus, hematuria, and preterm labor. Laboratory work-up showed severe coagulopathy with Prothrombin Time (PT) of 117. Read More

    High Dephosphorylated-Uncarboxylated MGP in Hemodialysis patients: risk factors and response to vitamin K, A pre-post intervention clinical trial.
    BMC Nephrol 2017 Jun 7;18(1):191. Epub 2017 Jun 7.
    Head of the Nephrology Department, Hôtel Dieu de France, Beirut. Saint-Joseph University, Beirut, Lebanon.
    Background: Vascular calcifications are highly prevalent in hemodialysis patients. Dephosphorylated-uncarboxylated MGP (dp-ucMGP) was found to increase in vitamin K-deficient patients and may be associated with vascular calcifications. Supplementation of hemodialysis patients with vitamin K (menaquinone-7) has been studied in Europe with a maximum 61% drop of dp-ucMGP levels. Read More

    [Intracranial hemorrhage secondary to vitamin K deficiency in an infant despite oral vitamin K prophylaxis : Also a challenge for the anesthesiologist].
    Anaesthesist 2017 Aug 2;66(8):598-603. Epub 2017 Jun 2.
    I. Klinik für Kinder und Jugendliche, Klinikum Augsburg, Augsburg, Deutschland.
    This article presents the case of a 6-week-old infant who, despite oral vitamin K prophylaxis and otherwise normal developmental progress, suffered a severe intracerebral and subdural hemorrhage, which required surgical evacuation. The interdisciplinary approach is described with emphasis on the management of hemostasis. Furthermore, the clinical picture of intracranial bleeding due to vitamin K deficiency, which is nowadays rare in the Western World, is described in the anesthesiology literature for the first time. Read More

    Nonhealing, progressive stress fractures of the foot in a 13-year-old basketball player: is vitamin K deficiency a risk factor?
    J Phys Ther Sci 2017 Apr 20;29(4):763-766. Epub 2017 Apr 20.
    Department of Physical Medicine and Rehabilitation, Acıbadem University School of Medicine, Turkey.
    [Purpose] To report an adolescent male basketball player with nonhealing stress fractures of the foot and discuss the probable factors. [Subject and Methods] A 13-year-old basketball player presented with right foot pain. He had been playing basketball for three years and practicing 5 days/week. Read More

    Phosphate binders affect vitamin K concentration by undesired binding, an in vitro study.
    BMC Nephrol 2017 May 2;18(1):149. Epub 2017 May 2.
    Department of Nephrology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
    Background: Vascular calcification is a major contributing factor to mortality in end stage renal disease (ESRD). Despite the efficacy of phosphate binders to improve hyperphosphatemia, data on vascular calcification are less clear. There seems to be a difference in attenuation or delay in progression between different binders. Read More

    The Coags Uncomplicated App: Fulfilling Educational Gaps Around Diagnosis and Laboratory Testing of Coagulation Disorders.
    JMIR Med Educ 2017 Apr 18;3(1):e6. Epub 2017 Apr 18.
    Novo Nordisk Inc., Plainsboro, NJ, United States.
    Background: Patients with coagulation disorders may present to a variety of physician specialties; however, accurate and efficient diagnosis can be challenging for physicians not specialized in hematology, due to identified gaps in knowledge around appropriate laboratory assays and interpretation of test results. Coags Uncomplicated was developed to fill this unmet educational need by increasing practical knowledge of coagulation disorders among nonexpert physicians and other health care professionals (HCPs) in a point-of-care (POC) setting.

    Objective: The aim of this study was to assess patterns of use of the mobile app Coags Uncomplicated, a tool designed to support education regarding accurate and efficient diagnosis of bleeding disorders. Read More

    Finding the optimal dose of vitamin K1 to treat vitamin K deficiency and to avoid anaphylactoid reactions.
    Fundam Clin Pharmacol 2017 Oct 24;31(5):495-505. Epub 2017 May 24.
    Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, 76 Yanta West Road, Xi'an, 710061, China.
    Vitamin K1 injection induces severe dose-related anaphylactoid reactions and overdose for the treatment of vitamin K deficiency. We aimed to find an optimal and small dose of vitamin K1 injection to treat vitamin K deficiency and avoid anaphylactoid reactions in animal. Rats were administered a vitamin K-deficient diet and gentamicin to establish vitamin K deficiency model. Read More

    Joint Association of Low Vitamin D and Vitamin K Status With Blood Pressure and Hypertension.
    Hypertension 2017 06 10;69(6):1165-1172. Epub 2017 Apr 10.
    From the Department of Health Sciences, and the EMGO Institute for Health and Care Research (A.J.v.B., A.C., M.V., I.A.B.), Department of Internal Medicine, Section of Nutrition and Dietetics (M.V.), and Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research (N.M.v.S., J.W.B.), VU University Medical Center, Amsterdam; and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht (J.W.B.).
    Low vitamin D and K status are both associated with an increased cardiovascular risk. New evidence from experimental studies on bone health suggest an interaction between vitamin D and K; however, a joint association with vascular health outcomes is largely unknown. To prospectively investigate whether the combination of low vitamin D and K status is associated with higher systolic and diastolic blood pressure in 402 participants and with incident hypertension in 231 participants free of hypertension at baseline. Read More

    Curr Opin Nephrol Hypertens 2017 07;26(4):276-281
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
    Purpose Of Review: Calciphylaxis remains a poorly understood vascular calcification disorder with predilection for patients with end-stage renal disease (ESRD). Recent data from large patient registries and databases have begun to provide information regarding incidence, risk factors, and outcomes in patients with calciphylaxis.

    Recent Findings: The most recent estimate places the incidence of calciphylaxis at 3. Read More

    Infantile Tremor Syndrome and Subdural Hemorrhage in an Infant with Cystic Fibrosis.
    J Trop Pediatr 2017 Aug;63(4):328-332
    Department of Pediatrics, All India Institute of Medical Sciences, New Delhi 110029, India.
    Cystic fibrosis (CF), an autosomal recessive disease with multi-system involvement, may present with bleeding in infancy owing to vitamin K malabsorption. Infantile tremor syndrome (ITS) is an obscure condition associated with vitamin B12 and other micronutrient deficiencies, described predominantly in Indian subcontinent. We describe an infant presenting with ITS and chronic subdural hemorrhage. Read More

    Detection of subclinical vitamin K deficiency in neurosurgery with PIVKA-II.
    Scand J Clin Lab Invest 2017 Jul 20;77(4):267-274. Epub 2017 Mar 20.
    a Department of Anaesthesia and Intensive Care, Institution of Clinical Science Lund, Medical Faculty , Lund University , Lund , Sweden.
    Vitamin K is known for supporting the carboxylation of hepatic coagulation proteins. Levels of proteins induced by vitamin K absence for factor II (PIVKA-II) reflect hypocarboxylated prothrombin and can be used to detect subclinical vitamin K deficiency. The aim of this study was to determine the prevalence of perioperative subclinical vitamin K deficiency among neurosurgical patients using PIVKA-II and investigate the existence of any correlation to standard coagulation assays. Read More

    The Strategy to Prevent and Regress the Vascular Calcification in Dialysis Patients.
    Biomed Res Int 2017 14;2017:9035193. Epub 2017 Feb 14.
    Division of Nephrology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Department of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan.
    The high prevalence of arterial calcification in end-stage renal disease (ESRD) is far beyond the explanation by common cardiovascular risk factors such as aging, diabetes, hypertension, and dyslipidemia. The finding relies on the fact that vascular and valvular calcifications are predictors of cardiovascular diseases and mortality in persons with chronic renal failure. In addition to traditional cardiovascular risk factors such as diabetes mellitus and blood pressure control, other ESRD-related risks such as phosphate retention, excess calcium, and prolonged dialysis time also contribute to the development of vascular calcification. Read More

    Susceptiveness of Vitamin K epOxide Reductase Complex Subunit 1 Gene Polymorphism in Essential Hypertension.
    Genet Test Mol Biomarkers 2017 May 10;21(5):292-297. Epub 2017 Mar 10.
    1 Department of Medical Biology, Faculty of Medicine, Eskisehir Osmangazi University , Eskisehir, Turkey .
    Background: Essential hypertension (EH) is defined as a worldwide public health problem and one of the important risk factors for development of human coronary artery disease. Increased peripheral arterial resistance is one of the distinguishing characteristics of EH. The extracellular deposition of calcium in the arterial wall is defined as vascular calcification, which results in aortic stiffness and elevation of blood pressure. Read More

    Effectiveness of prothrombin complex concentrate (PCC) in neonates and infants with bleeding or risk of bleeding: a systematic review and meta-analysis.
    Eur J Pediatr 2017 May 9;176(5):581-589. Epub 2017 Mar 9.
    Department of Neonatology, West China Second University Hospital, Sichuan University, Chengdu, China.
    To systematically evaluate the effectiveness of prothrombin complex concentrate (PCC) in neonates and infants, we performed a systematic review and meta-analysis based on current evidence. Quality of studies was assessed by Cochrane Collaboration's risk of bias tool and Newcastle-Ottawa quality assessment scale. For dichotomous data, we obtained the number of events and total number and calculated the relative risk (RR) with 95% confidence intervals (CI). Read More

    Vitamin K Deficiency Presenting in an Infant with an Anterior Mediastinal Mass: A Case Report and Review of the Literature.
    Case Rep Pediatr 2017 9;2017:7628946. Epub 2017 Feb 9.
    School of Medicine, University of Colorado, Boulder, CO, USA.
    We report a case of a 1-month-old infant with spontaneous thymic hemorrhage secondary to severe vitamin K deficiency. He was brought to medical attention due to scrotal bruising and during evaluation was noted to be tachypneic and hypoxemic. Chest X-ray revealed an enlarged cardiothymic silhouette, and a follow-up echocardiogram revealed a mass in the anterior mediastinum. Read More

    Refusal of Vitamin K by Parents of Newborns: A Survey of the Better Outcomes Through Research for Newborns Network.
    Acad Pediatr 2017 May - Jun;17(4):368-373. Epub 2017 Mar 9.
    Department of Pediatrics, Yale University, New Haven, Conn.
    Objective: To survey newborn clinicians in the United States regarding the frequency of intramuscular (IM) vitamin K refusal by a parent, reasons for refusal, and approaches of clinicians to refusals.

    Methods: An electronic survey was administered to the clinician site representative (nursery director or designee knowledgeable about site-specific nursery policies) at all newborn nurseries in the Better Outcomes through Research for Newborns (BORN) network of newborn nurseries.

    Results: Of 92 BORN sites, 85 (92%) respondents completed the survey. Read More

    The Presentation of a Fussy Infant With Bruising: Late-Onset Vitamin K Deficiency Bleeding.
    Pediatr Emerg Care 2017 Feb 21. Epub 2017 Feb 21.
    From the *Department of Pediatrics and †Division of Pediatric Emergency Medicine, University of Utah, Salt Lake City, UT.
    Vitamin K plays an integral role in the clotting cascade. Deficiency, specifically in vulnerable neonates with insufficient stores, can lead to spontaneous bleeding and devastating effects. In this case, we report a young infant with late-onset vitamin K deficiency bleeding who did not receive vitamin K prophylaxis after birth. Read More

    Vitamin K status in cystic fibrosis patients with liver cirrhosis.
    Dig Liver Dis 2017 Jun 23;49(6):672-675. Epub 2017 Jan 23.
    Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznan, Poland. Electronic address:
    The available data on the influence of liver cirrhosis on vitamin K status in CF patients is scarce. Therefore, the aims of the present study were to assess the prevalence of vitamin K deficiency in cirrhotic CF subjects and to determine whether it correlates with liver cirrhosis. The study group comprised of 27 CF patients with and 63 without liver cirrhosis. Read More

    Diagnostic Error of a Patient with Combined Inherited Factor VII and Factor X Deficiency due to Accidental Ingestion of a Diphacinone Rodenticide.
    Clin Lab 2016 Nov;62(11):2253-2256
    Background: To explore the characteristics of laboratory examination and confirm the diagnosis of a patient with combined inherited FVII and FX deficiency after he ingested diphacinone rodenticide accidentally.

    Methods: The coagulant parameter screening tests and coagulation factor activities were tested many times in the patient due to accidental ingestion of a diphacinone rodenticide. After the patient was treated for more than one year, gene analysis of correlated coagulation factors was analyzed in the patient and other family members by DNA direct sequencing. Read More

    Parental Refusal of Vitamin K and Neonatal Preventive Services: A Need for Surveillance.
    Matern Child Health J 2017 05;21(5):1079-1084
    Centers for Disease Control and Prevention, Division of Blood Disorders, National Center on Birth Defects and Developmental Disabilities, Atlanta, GA, USA.
    Objectives Vitamin K deficiency bleeding (VKDB) in infants is a coagulopathy preventable with a single dose of injectable vitamin K at birth. The Tennessee Department of Health (TDH) and Centers for Disease Control and Prevention (CDC) investigated vitamin K refusal among parents in 2013 after learning of four cases of VKDB associated with prophylaxis refusal. Methods Chart reviews were conducted at Nashville-area hospitals for 2011-2013 and Tennessee birthing centers for 2013 to identify parents who had refused injectable vitamin K for their infants. Read More

    Vitamin K-Dependent Carboxylation of Matrix Gla Protein Influences the Risk of Calciphylaxis.
    J Am Soc Nephrol 2017 Jun 3;28(6):1717-1722. Epub 2017 Jan 3.
    Cardiology, and.
    Matrix Gla protein (MGP) is a potent inhibitor of vascular calcification. The ability of MGP to inhibit calcification requires the activity of a vitamin K-dependent enzyme, which mediates MGP carboxylation. We investigated how MGP carboxylation influences the risk of calciphylaxis in adult patients receiving dialysis and examined the effects of vitamin K deficiency on MGP carboxylation. Read More

    Synthesis of 2-methyl-1,4-naphthoquinones with higher gamma-glutamyl carboxylase activity than MK-4 both in vitro and in vivo.
    Bioorg Med Chem Lett 2017 01 25;27(2):208-211. Epub 2016 Nov 25.
    R&D Group VitaK, Maastricht University, Oxfordlaan 70, 6229 EV Maastricht, The Netherlands.
    Vitamin K is the collective term for compounds that share a 2-methyl-1,4-naphthoquinone ring, but differ in the side-chain at the 3-position. We synthesized novel 2-methyl-1,4-naphthoquinone derivatives with different side chain length at the 3-position. Derivatives with C-14 and C-16 tails showed the highest in vitro bioactivity resulting in 2. Read More

    Correlations of Plasma Desphosphorylated Uncarboxylated Matrix Gla Protein with Vascular Calcification and Vascular Stiffness in Chronic Kidney Disease.
    Nephron 2017 13;135(3):167-172. Epub 2016 Dec 13.
    Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
    Background: Matrix Gla protein (MGP) is a potent inhibitor of vascular calcification and needs vitamin K-dependent carboxylation for its activity. High levels of desphosphorylated uncarboxylated MGP (dp-ucMGP) were significantly associated with vitamin K deficiency and vascular calcification. This study was conducted to explore the correlations of plasma dp-ucMGP with vascular calcification and vascular stiffness in chronic kidney disease (CKD) patients. Read More

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