Search our Database of Scientific Publications and Authors

I’m looking for a

    2365 results match your criteria Vitamin K Deficiency

    1 OF 48

    Vitamin K status in cystic fibrosis patients with liver cirrhosis.
    Dig Liver Dis 2017 Jan 23. Epub 2017 Jan 23.
    Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznan, Poland. Electronic address:
    The available data on the influence of liver cirrhosis on vitamin K status in CF patients is scarce. Therefore, the aims of the present study were to assess the prevalence of vitamin K deficiency in cirrhotic CF subjects and to determine whether it correlates with liver cirrhosis. The study group comprised of 27 CF patients with and 63 without liver cirrhosis. Read More

    Diagnostic Error of a Patient with Combined Inherited Factor VII and Factor X Deficiency due to Accidental Ingestion of a Diphacinone Rodenticide.
    Clin Lab 2016 Nov;62(11):2253-2256
    Background: To explore the characteristics of laboratory examination and confirm the diagnosis of a patient with combined inherited FVII and FX deficiency after he ingested diphacinone rodenticide accidentally.

    Methods: The coagulant parameter screening tests and coagulation factor activities were tested many times in the patient due to accidental ingestion of a diphacinone rodenticide. After the patient was treated for more than one year, gene analysis of correlated coagulation factors was analyzed in the patient and other family members by DNA direct sequencing. Read More

    Parental Refusal of Vitamin K and Neonatal Preventive Services: A Need for Surveillance.
    Matern Child Health J 2017 Jan 4. Epub 2017 Jan 4.
    Centers for Disease Control and Prevention, Division of Blood Disorders, National Center on Birth Defects and Developmental Disabilities, Atlanta, GA, USA.
    Objectives Vitamin K deficiency bleeding (VKDB) in infants is a coagulopathy preventable with a single dose of injectable vitamin K at birth. The Tennessee Department of Health (TDH) and Centers for Disease Control and Prevention (CDC) investigated vitamin K refusal among parents in 2013 after learning of four cases of VKDB associated with prophylaxis refusal. Methods Chart reviews were conducted at Nashville-area hospitals for 2011-2013 and Tennessee birthing centers for 2013 to identify parents who had refused injectable vitamin K for their infants. Read More

    Vitamin K-Dependent Carboxylation of Matrix Gla Protein Influences the Risk of Calciphylaxis.
    J Am Soc Nephrol 2017 Jan 3. Epub 2017 Jan 3.
    Cardiology, and.
    Matrix Gla protein (MGP) is a potent inhibitor of vascular calcification. The ability of MGP to inhibit calcification requires the activity of a vitamin K-dependent enzyme, which mediates MGP carboxylation. We investigated how MGP carboxylation influences the risk of calciphylaxis in adult patients receiving dialysis and examined the effects of vitamin K deficiency on MGP carboxylation. Read More

    Synthesis of 2-methyl-1,4-naphthoquinones with higher gamma-glutamyl carboxylase activity than MK-4 both in vitro and in vivo.
    Bioorg Med Chem Lett 2017 Jan 25;27(2):208-211. Epub 2016 Nov 25.
    R&D Group VitaK, Maastricht University, Oxfordlaan 70, 6229 EV Maastricht, The Netherlands.
    Vitamin K is the collective term for compounds that share a 2-methyl-1,4-naphthoquinone ring, but differ in the side-chain at the 3-position. We synthesized novel 2-methyl-1,4-naphthoquinone derivatives with different side chain length at the 3-position. Derivatives with C-14 and C-16 tails showed the highest in vitro bioactivity resulting in 2. Read More

    Correlations of Plasma Desphosphorylated Uncarboxylated Matrix Gla Protein with Vascular Calcification and Vascular Stiffness in Chronic Kidney Disease.
    Nephron 2016 Dec 13. Epub 2016 Dec 13.
    Division of Nephrology, Department of Medicine, Chulalongkorn University, Bangkok, Thailand.
    Background: Matrix Gla protein (MGP) is a potent inhibitor of vascular calcification and needs vitamin K-dependent carboxylation for its activity. High levels of desphosphorylated uncarboxylated MGP (dp-ucMGP) were significantly associated with vitamin K deficiency and vascular calcification. This study was conducted to explore the correlations of plasma dp-ucMGP with vascular calcification and vascular stiffness in chronic kidney disease (CKD) patients. Read More

    Newborn vitamin K prophylaxis: an analysis of information resources for parents and professionals.
    N Z Med J 2016 Dec 2;129(1446):44-52. Epub 2016 Dec 2.
    Bioethics Centre, University of Otago, Dunedin.
    Aims: Vitamin K prophylaxis represents one of the first healthcare decisions families make for their newborn. Information resources are an important component of this process. This study aimed to identify and analyse written information about vitamin K. Read More

    Vitamin K supplementation to prevent hemorrhagic morbidity and mortality of newborns in India and China.
    World J Pediatr 2017 Feb 15;13(1):15-19. Epub 2016 Nov 15.
    Braun School Public Health and Community Medicine, Hebrew University-Hadassah, Ein Karem, Jerusalem, Israel.
    Background: Vitamin K deficiency bleeding (VKDB) can cause prolonged and bleeding (intracranial hemorrhage) among newborns, which can be life-threatening or lead to long-term morbidity. The aim of this review article is to reiterate empirical evidence to support the argument that vitamin K should be mandatory for newborns in India and China, as well as in other countries with a high burden of neonatal deaths.

    Data Sources: Studies were integrated from the PubMed/MEDLINE database search, as well as related literature available elsewhere. Read More

    Vitamin K Metabolism in a Rat Model of Chronic Kidney Disease.
    Am J Nephrol 2017 16;45(1):4-13. Epub 2016 Nov 16.
    Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ont., Canada.
    Background: Patients with chronic kidney disease (CKD) have very high levels of uncarboxylated, inactive, extra-hepatic vitamin K-dependent proteins measured in circulation, putting them at risk for complications of vitamin K deficiency. The major form of vitamin K found in the liver is phylloquinone (K1). Menaquinone-4 (MK-4) is the form of vitamin K that is preferentially found in extra-hepatic tissues. Read More

    Vitamin-K-Dependent Protection of the Renal Microvasculature: Histopathological Studies in Normal and Diseased Kidneys.
    Pulse (Basel) 2016 Sep 24;4(2-3):85-91. Epub 2016 Aug 24.
    Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium; R & D Group VitaK, Maastricht University, Maastricht, The Netherlands.
    Vitamin-K-dependent carboxylation of matrix Gla protein (MGP) protects the macrocirculation against calcification. We recently reported in a multiethnic population study that the estimated glomerular filtration rate, a microvascular trait, decreased and the risk of chronic kidney disease increased with higher circulating levels of inactive dephospho-uncarboxylated MGP, a marker of vitamin K deficiency. These findings highlighted the possibility that vitamin K might have a beneficial effect on the renal microcirculation. Read More

    Vitamin K homologs as potential biomarkers for disease activity in patients with rheumatoid arthritis.
    J Bone Miner Metab 2016 Oct 8. Epub 2016 Oct 8.
    Department of Rheumatology, King Fahd Hospital, Al Madinah AlMunawarah, Saudi Arabia.
    The aim of this study was to evaluate the possible role of vitamin K homologs as potential biomarkers for disease activity in patients with rheumatoid arthritis (RA). In this study, 42 patients with RA and 40 healthy controls were enrolled. Serum levels of vitamin K homologs were measured using a high-performance liquid chromatography-fluorescence method. Read More

    Deficiency of fat-soluble vitamins in chronic pancreatitis: A systematic review and meta-analysis.
    Pancreatology 2016 Nov - Dec;16(6):988-994. Epub 2016 Sep 20.
    Digestive & Liver Disease Unit, S. Andrea Hospital, University "Sapienza", Rome, Italy. Electronic address:
    Background And Aims: Chronic pancreatitis (CP) patients are at risk for fat-soluble vitamins (A, D, E, K) deficiency, but available studies are small and heterogeneous. We conducted a systematic review and meta-analysis to determine the prevalence of fat-soluble vitamins deficiency in CP patients.

    Methods: Medline was searched up to January 2016 for case series and case-control studies reporting prevalence of fat-soluble vitamin deficiency in CP patients. Read More

    Neonatal Prophylaxis: Prevention of Vitamin K Deficiency Haemorrhage and Neonatal Ophthalmia.
    Zdr Varst 2015 Sep 9;54(3):184-93. Epub 2015 Jun 9.
    University of Ljubljana, Faculty of Health Sciences, Zdravstvena pot 1, 1000 Ljubljana, Slovenia.
    Introduction: The aim of the study was to explore two aspects of neonatal prophylaxis: the application of the vitamin K injection to the newborns and the prophylaxis against chlamydial and gonococcal eye infections, comparing Slovenian and Croatian practices.

    Methods: A causal non-experimental method of quantitative empirical approach was used. The data was collected by means of predesigned questionnaires. Read More

    Intraperitoneal Hemorrhage in a Pregnant Woman with Hyperemesis Gravidarum: Vitamin K Deficiency as a Possible Cause.
    Case Rep Obstet Gynecol 2016 11;2016:5384943. Epub 2016 Aug 11.
    Department of Obstetrics and Gynecology, Jichi Medical University, Tochigi 09216, Japan.
    Hyperemesis gravidarum can cause various vitamin deficiencies. Vitamin K deficiency can lead to coagulopathy or hemorrhagic diathesis. A nulliparous Japanese woman with hyperemesis gravidarum at 10(5/7) weeks was admitted with giant myoma, intestinal obstruction, and abdominal pain. Read More

    Seasonal variation in the international normalized ratio of neonates and its relationship with ambient temperature.
    BMC Pediatr 2016 Jul 19;16:97. Epub 2016 Jul 19.
    Department of Regional Neonatal-Perinatal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.
    Background: The morbidity and mortality rates due to cardiovascular events such as myocardial infarction are known to exhibit seasonal variations. Moreover, changes in the ambient temperature are reportedly associated with an increase in these events, which may potentially involve blood coagulation markers. Bleeding due to vitamin K deficiency in neonates, which is associated with high mortality and a high frequency of neurological sequelae, is more commonly observed during the summer season and in warm regions in Japan. Read More

    Prevention of Vitamin K Deficiency Bleeding.
    J Midwifery Womens Health 2016 Jul 7. Epub 2016 Jul 7.
    The risk that a newborn will develop vitamin K deficiency bleeding is 1700/100,000 (one out of 59) if vitamin K is not administered. When intramuscular vitamin K is administered, the risk of vitamin K deficiency bleeding is reduced to 1/100,000. While women may have misconceptions about vitamin K prophylaxis for their newborns, health care providers should be prepared with factual information. Read More

    A Blown Pupil and Intracranial Hemorrhage in a 4-Week-Old: A Case of Delayed Onset Vitamin K Deficiency Bleeding, a Rare "Can't Miss" Diagnosis.
    J Emerg Med 2016 Aug 11;51(2):164-7. Epub 2016 Jun 11.
    Department of Emergency Medicine, Maine Medical Center, Portland, Maine.
    Background: Infants are at risk for vitamin K deficiency bleeding (VKDB) because of limited stores of vitamin K (VK) at birth and a low concentration of VK in human breast milk. Therefore, the administration of intramuscular (IM) VK at birth has been recommended since 1961 in the United States. Infants who do not receive IM VK and who are exclusively breast-fed are at increased risk for VKDB. Read More

    Gastrointestinal bleeding secondary to trimethoprim-sulfamethoxazole-induced vitamin K deficiency.
    BMJ Case Rep 2016 Jun 6;2016. Epub 2016 Jun 6.
    Department of Internal Medicine, University of Arizona Medical Center-University Campus, Tucson, Arizona, USA.
    There is a well-known association between vitamin K deficiency and haemorrhagic events including gastrointestinal bleeding. There is also a well-known association between both poor dietary intake of vitamin K and chronic antibiotic use and the development of vitamin K deficiency. Although the medical literature notes that cephalosporin antibiotics have a propensity to cause vitamin K deficiency due to the molecular structure of the medications and their ability to suppress the synthesis of clotting factors, there are other antibiotics that have also been implicated in the development of vitamin K deficiency. Read More

    Establishing a rat model for the study of vitamin K deficiency.
    Int J Exp Pathol 2016 Apr 3;97(2):187-93. Epub 2016 Jun 3.
    Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
    The main vitamin K-deficient model, minidose warfarin, is different from the pathological mechanism of vitamin K deficiency, which is a shortage of vitamin K. The objective of this study was to establish a new method of vitamin K-deficient model combining a vitamin K-deficient diet with the intragastrical administration of gentamicin in rats. The clotting was assayed by an automated coagulation analyser. Read More

    The role of vitamin K in vascular calcification of patients with chronic kidney disease.
    Acta Clin Belg 2016 Dec 25;71(6):462-467. Epub 2016 May 25.
    a Department of Internal Medicine, Renal Division , Ghent University Hospital , Ghent , Belgium.
    Patients with chronic kidney disease (CKD) are prone to vascular calcification. Pathogenetic mechanisms of vascular calcifications have been broadly studied and discussed such as the role of hyperphosphatemia, hypercalcemia, parathormone, and vitamin D. In recent years, new insights have been gained pointing to vitamin K as a main actor. Read More

    Prophylactic Dosing of Vitamin K to Prevent Bleeding.
    Pediatrics 2016 May;137(5)
    Pediatric Gastroenterology and Hepatology, Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; and
    Background And Objectives: Based on a high incidence of Vitamin K deficiency bleeding (VKDB) in breastfed infants with thus far unrecognized cholestasis, such as biliary atresia (BA), the Dutch regimen to prevent VKDB in breastfed infants was changed from a daily oral dosage of 25 µg to 150 µg vitamin K. Infants continued to receive 1 mg of vitamin K orally at birth. We compared the efficacy of the 150-µg regimen with the 25-µg regimen and with the Danish regimen of a single intramuscular (IM) dose of 2 mg vitamin K at birth. Read More

    Low vitamin K1 intake in haemodialysis patients.
    Clin Nutr 2016 Apr 28. Epub 2016 Apr 28.
    Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
    Background & Aims: Vitamin K acts as a coenzyme in the γ-carboxylation of vitamin K-dependent proteins, including coagulation factors, osteocalcin, matrix Gla protein (MGP), and the growth arrest-specific 6 (GAS6) protein. Osteocalcin is a key factor for bone matrix formation. MGP is a local inhibitor of soft tissue calcification. Read More

    Changes in fat-soluble vitamin levels after gastrectomy for gastric cancer.
    Surg Today 2017 Feb 25;47(2):145-150. Epub 2016 May 25.
    Department of Surgery, School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
    Several authors have reported the relationship between gastric cancer risk and vitamins. However, there are few reports on fat-soluble vitamins after gastrectomy for gastric cancer. Fat malabsorption and suppression of food intake after gastrectomy for gastric cancer have been previously documented. Read More

    PIVKA-II correlates with INR but not protein C or protein S concentrations in cord blood among newborns.
    J Neonatal Perinatal Med 2016 May;9(2):139-43
    Baylor College of Medicine, Houston, TX, USA.
    Background: Protein induced by vitamin K absence (PIVKA)-II, inactive precursor of prothrombin, is elevated in vitamin K (VK) deficiency. Our aims were to find the prevalence of VK deficiency in neonates, assess the utility of international normalized ratio (INR) as a screening tool, and explore the relationship between PIVKA-II, activated partial thromboplastin time (aPTT) and VK dependent anticoagulants.

    Methods: INR, aPTT, PIVKA-II, and proteins C and S activities were measured in neonatal cord blood prior to VK administration. Read More

    [Serious Coagulation Dysfunction in a Patient with Gallstone-related Cholecystitis Successfully Treated with Vitamin K].
    Masui 2016 Apr;65(4):407-10
    An 85-year-old woman with a diagnosis of choledocholithiasis due to common duct stones gradually developed severe coagulation dysfunction over the course of 27 days after hospitalization. Initial clinical findings were fever, general malaise, and obstructive jaundice. She was treated with fasting, and received cephem antibiotics containing N-methyl-thio-tetrazole. Read More

    Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review.
    J Perinatol 2016 May;36 Suppl 1:S29-35
    Newborn Health Knowledge Centre (NHKC), ICMR Center for Advanced Research in Newborn Health, WHO Collaborating Centre for Training and Research in Newborn Care, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
    We conducted a systematic review to evaluate the burden of late vitamin K deficiency bleeding (VKDB) and the effect of vitamin K prophylaxis on the incidence of VKDB. We searched MEDLINE and other electronic databases, and included all observational studies including population surveys as well as randomized controlled trials (RCT). The median (interquartile range) burden of late VKDB was 35 (10. Read More

    Prevention of Vitamin K Deficiency Bleeding in Newborn Infants: A Position Paper by the ESPGHAN Committee on Nutrition.
    J Pediatr Gastroenterol Nutr 2016 Jul;63(1):123-9
    *Department of Pediatrics, Harlaching, Munich Municipal Hospitals, Munich, Germany†Department of Pediatric Gastroenterology, University Children's Hospital, Zurich, Switzerland‡Department Pediatrics, University Hospital Motol, Prague, Czech Republic§Department of Pediatrics, University of Granada, Granada, Spain||Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden¶Childhood Nutrition Research Centre, UCL Institute of Child Health, London, UK#Department of Gastroenterology, Hepatology and Nutrition, University Children's Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia**University Children's Hospital Zagreb, Zagreb, Croatia††Department of Pediatrics, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands‡‡Department of Pediatrics, University Hospital Giovanni XXIII, University Aldo Moro, Bari, Italy§§APHP Necker-Enfants Malades Hospital, Paris Descartes University, Paris, France||||CNRC, Baylor College of Medicine, Houston, TX¶¶Department of Nutrition, Exercise and Sports, University of Copenhagen, K⊘benhavn##Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark***Newcastle Neonatal Service, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK†††Department of Pediatrics, VU University Medical Center‡‡‡Department of Pediatrics, Emma Children's Hospital-AMC, Amsterdam, The Netherlands.
    Vitamin K deficiency bleeding (VKDB) due to physiologically low vitamin K plasma concentrations is a serious risk for newborn and young infants and can be largely prevented by adequate vitamin K supplementation. The aim of this position paper is to define the condition, describe the prevalence, discuss current prophylaxis practices and outcomes, and to provide recommendations for the prevention of VKDB in healthy term newborns and infants. All newborn infants should receive vitamin K prophylaxis and the date, dose, and mode of administration should be documented. Read More

    Functional deficiency of vitamin K in hemodialysis patients in Upper Silesia in Poland.
    Int Urol Nephrol 2016 May 21;48(5):765-71. Epub 2016 Mar 21.
    Department of Pathophysiology, Medical Faculty in Katowice, Medical University of Silesia, Medyków 18 Street, 40-752, Katowice, Poland.
    Purpose: Functional vitamin K deficiency (both K1 and K2) is postulated to be one of the most relevant links between chronic kidney disease and vascular calcification in hemodialysis (HD) patients. Recommended dietary restrictions in HD patients superimposed on diversity of eating habits across the countries may affect the prevalence of functional vitamin K deficiency. The aim of this study was to determine the level of functional vitamin K deficiency and its relation to vitamin K1 intake in HD patients in Upper Silesia in Poland. Read More

    Effectiveness of a computerized decision support system for anticoagulation management in hemodialysis patients: A before-after study.
    Hemodial Int 2016 Oct 17;20(4):530-536. Epub 2016 Mar 17.
    Division of Nephrology, Department of Medicine and Kidney Research Centre, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada.
    Introduction The risk-benefit profile for warfarin anticoagulation in hemodialysis (HD) patients differs compared with the non-HD population. HD patients are at increased risk of both thromboembolism and bleeding related to anticoagulation therapy. In addition, anticoagulation control may be more difficult to achieve in the HD population due to frequent comorbidities, subclinical Vitamin K deficiency, altered pharmacokinetics due to uremia and the concurrent use of multiple medications. Read More

    The effects of vitamin K supplementation and vitamin K antagonists on progression of vascular calcification: ongoing randomized controlled trials.
    Clin Kidney J 2016 Apr 29;9(2):273-9. Epub 2015 Dec 29.
    Division of Nephrology and Infectious Diseases , AZ Sint-Jan Brugge , Brugge , Belgium.
    Background: The extent and the progression of vascular calcification (VC) are independent predictors of cardiovascular risk in the haemodialysis population. Vitamin K is essential for the activation of matrix gla protein (MGP), a powerful inhibitor of tissue calcification. Functional vitamin K deficiency may contribute to the high VC burden in haemodialysis patients. Read More

    Biological Systems of Vitamin K: A Plasma Nutriproteomics Study of Subclinical Vitamin K Deficiency in 500 Nepalese Children.
    OMICS 2016 Apr 25;20(4):214-23. Epub 2016 Feb 25.
    1 Center for Human Nutrition, Departments of International Health, Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland.
    Vitamin K (VK) is a fat-soluble vitamin whose deficiency disrupts coagulation and may disturb bone and cardiovascular health. However, the scale and systems affected by VK deficiency in pediatric populations remains unclear. We conducted a study of the plasma proteome of 500 Nepalese children 6-8 years of age (male/female ratio = 0. Read More

    Management of vitamin K deficiency after biliopancreatic diversion with or without duodenal switch.
    Surg Obes Relat Dis 2016 Feb 1;12(2):338-44. Epub 2015 Oct 1.
    Department of Internal Medicine, Rijnstate Hospital, Arnhem, The Netherlands.
    Background: Reduced serum vitamin K levels are frequently observed after biliopancreatic diversion (BPD) and BPD with duodenal switch (BPD/DS). The criteria for treatment are not precisely defined.

    Objectives: To assess the effects of standardized vitamin K supplementation in patients who develop vitamin K deficiency after BPD or BPD/DS. Read More

    Proper Calcium Use: Vitamin K2 as a Promoter of Bone and Cardiovascular Health.
    Integr Med (Encinitas) 2015 Feb;14(1):34-9
    is the president and scientific coordinator of International Science and Health Foundation in Krakow, Poland.
    Inadequate calcium intake can lead to decreased bone mineral density, which can increase the risk of bone fractures. Supplemental calcium promotes bone mineral density and strength and can prevent osteoporosis. Recent scientific evidence, however, suggests that elevated consumption of calcium supplements may raise the risk for heart disease and can be connected with accelerated deposit of calcium in blood-vessel walls and soft tissues. Read More

    Characterization of vitamin K-dependent carboxylase mutations that cause bleeding and nonbleeding disorders.
    Blood 2016 Apr 12;127(15):1847-55. Epub 2016 Jan 12.
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC;
    Vitamin K-dependent coagulation factors deficiency is a bleeding disorder mainly associated with mutations in γ-glutamyl carboxylase (GGCX) that often has fatal outcomes. Some patients with nonbleeding syndromes linked to GGCX mutations, however, show no coagulation abnormalities. The correlation between GGCX genotypes and their clinical phenotypes has been previously unknown. Read More

    Reasons for Refusal of Newborn Vitamin K Prophylaxis: Implications for Management and Education.
    Hosp Pediatr 2016 Jan;6(1):15-21
    Department of Pediatrics and
    Objective: The American Academy of Pediatrics recommends intramuscular (IM) vitamin K prophylaxis for all newborns to prevent vitamin K deficiency bleeding. Given the serious implications of late-onset vitamin K deficiency bleeding, our objective was to examine factors influencing parents' decisions to refuse IM vitamin K prophylaxis.

    Methods: Parents intending to refuse IM vitamin K prophylaxis at delivery were recruited from 5 community hospitals, 1 academic medical center, and 2 birthing centers in a single Southeastern state. Read More

    Chronic Kidney Disease-Mineral Bone Disorder in the Elderly Peritoneal Dialysis Patient.
    Perit Dial Int 2015 Nov;35(6):640-4
    Department of Medicine, Roskilde Hospital, University of Copenhagen, Copenhagen, Denmark
    Purpose: The purpose of this paper was to review the literature concerning the treatment of chronic kidney disease-mineral bone disorder (CKD-MBD) in the elderly peritoneal dialysis (PD) patient.

    Results: Chronic kidney disease-mineral bone disorder is a major problem in the elderly PD patient, with its associated increased fracture risk, vascular calcification, and accelerated mortality fracture risk. Peritoneal dialysis, however, bears a lower risk than hemodialysis (HD). Read More

    A combination of low serum concentrations of vitamins K1 and D is associated with increased risk of hip fractures in elderly Norwegians: a NOREPOS study.
    Osteoporos Int 2016 Apr 2;27(4):1645-52. Epub 2015 Dec 2.
    Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.
    Unlabelled: The present study investigated the risk of incident hip fractures according to serum concentrations of vitamin K1 and 25-hydroxyvitamin D in elderly Norwegians during long-term follow-up. The results showed that the combination of low concentrations of both vitamin D and K1 provides a significant risk factor for hip fractures.

    Introduction: This case-cohort study aims to investigate the associations between serum vitamin K1 and hip fracture and the possible effect of 25-hydroxyvitamin D (25(OH)D) on this association. Read More

    The serum level of NX-DCP-R, but not DCP, is not increased in alcoholic liver disease without hepatocellular carcinoma.
    Cancer Biomark 2016 ;16(1):171-80
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
    Background And Aim: Alcoholic liver disease (ALD) is the most common cause of hepatocellular carcinoma (HCC) worldwide. Des-gamma-carboxy prothrombin (DCP) is elevated in many patients with HCC, but also in severe alcoholics without HCC. We aimed to clarify whether the DCP/NX-DCP ratio (NX-DCP-R) could have a high specificity in ALD patients without HCC. Read More

    Late Vitamin K Deficient Bleeding in 2 Young Infants--Renaissance of a Preventable Disease.
    Z Geburtshilfe Neonatol 2015 Oct 10;219(5):238-42. Epub 2015 Nov 10.
    University Children's Hospital, Wuerzburg, Wuerzburg, Germany.
    Introduction: Late vitamin K deficiency bleeding in young infants is a rare disorder which occurs almost exclusively in breast-fed infants who did not receive proper vitamin K prophylaxis at birth and who might additionally suffer from cholestasis. Its impact on morbidity is high since in 50% of the cases it presents with intracranial hemorrhage with a mortality rate of 20% and life-long neurologic sequelae in 30% of the affected infants.

    Case Reports: 2 male infants were both admitted to our unit at the age of 5 weeks with subdural hematoma with midline shift due to late vitamin K deficiency bleeding. Read More

    Prevalence and Predictors of Functional Vitamin K Insufficiency in Mothers and Newborns in Uganda.
    Nutrients 2015 Oct 16;7(10):8545-52. Epub 2015 Oct 16.
    Department of Pediatrics and Child Health, Mbarara University of Science and Technology, Plot 8-18 Mbarara-Kabale road, P.O. Box 1410, Mbarara, Uganda.
    Vitamin K deficiency bleeding (VKDB) in infancy is a serious but preventable cause of mortality or permanent disability. Lack of epidemiologic data for VKDB in sub-Saharan Africa hinders development and implementation of effective prevention strategies. We used convenience sampling to consecutively enroll mothers delivering in a southwestern Uganda Hospital. Read More

    Early Vitamin K Deficiency Bleeding in a Neonate Associated with Maternal Acute Fatty Liver of Pregnancy.
    AJP Rep 2015 Oct 7;5(2):e193-5. Epub 2015 Sep 7.
    Department of Radiology, University of Texas Medical Branch Galveston, Galveston, Texas.
    Introduction Acute fatty liver of pregnancy (AFLP) is a rare but potentially fatal condition occurring in the third trimester or early postpartum period. It is characterized by microvesicular fatty infiltration of the liver. Clinically, the three most prominent derangements in women with AFLP are hepatic dysfunction, renal insufficiency, and impaired coagulation. Read More

    Vitamin K Status Is not Associated with Cognitive Decline in Middle Aged Adults.
    J Nutr Health Aging 2015 Nov;19(9):908-12
    H.C. Comijs, GGZ in Geest/ Department of Psychiatry, A.J. Ernststraat 1187, 1081 HL Amsterdam, The Netherlands. Tel.: +31-20-7885699;fax: +31-20-4446775. E-mail address:
    Objectives: The aim of this study was to examine the association between dephospho-uncarboxylated matrix Gla protein (dp-ucMGP), an indicator of vitamin K status, and cognitive decline, and the modifying role of 25(OH)D.

    Design: Longitudinal study with six years follow-up.

    Setting: Community based. Read More

    Use of Vitamin K Antagonists and Brain Volumetry in Older Adults: Preliminary Results From the GAIT Study.
    J Am Geriatr Soc 2015 Oct;63(10):2199-202
    Department of Neuroscience, Division of Geriatric Medicine, Laboratoire de Psychologie des Pays de la Loire, L'Université Nantes Angers Le Mans, Angers University Hospital, Angers, France.

    The health benefits of vitamin K.
    Open Heart 2015 6;2(1):e000300. Epub 2015 Oct 6.
    Mid America Heart Institute at Saint Luke's Hospital , Kansas City, Missouri , USA.
    Vitamin K has important functions within the body, some of which are still being discovered. Research has shown that vitamin K is an anticalcification, anticancer, bone-forming and insulin-sensitising molecule. Recent data indicate that subclinical vitamin K deficiency is not uncommon. Read More

    Vitamin K antagonism aggravates chronic kidney disease-induced neointimal hyperplasia and calcification in arterialized veins: role of vitamin K treatment?
    Kidney Int 2016 Mar;89(3):601-11
    Arteriovenous fistula (AVF) is the common vascular access type for a hemodialysis patient. Its failure is due to neointimal hyperplasia. Vitamin K antagonists are given to lower thrombosis tendency, but have side effects that enhance arterial calcifications. Read More

    1 OF 48