3,850 results match your criteria Vitamin E Toxicity


Ameliorating efficacy of eugenol against metanil yellow induced toxicity in albino Wistar rats.

Food Chem Toxicol 2019 Feb 7;126:34-40. Epub 2019 Feb 7.

Department of Biochemistry, University of Allahabad, Allahabad, 211002, India. Electronic address:

Metanil yellow, an azo dye, is a non-permitted synthetic food colour used extensively in India and other developing countries as food additive. Present communication reports the toxic effects of metanil yellow on hepatic and kidney tissues and its amelioration by eugenol, vitamin E and vitamin C. Oral administration of metanil yellow in albino Wistar rats for 28 days caused elevation in serum enzymes (glutamate oxaloacetate transaminase, gluatamate pyruvate transaminase, alkaline phosphatase), and total bilirubin along with decline in albumin and total protein levels. Read More

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http://dx.doi.org/10.1016/j.fct.2019.01.032DOI Listing
February 2019
2 Reads

Vitamin E reduces the extent of mouse brain damage induced by combined exposure to formaldehyde and PM2.5.

Ecotoxicol Environ Saf 2019 Jan 19;172:33-39. Epub 2019 Jan 19.

Department of Food Science and Engineering, Moutai Institute, Renhuai 564507, China; Laboratory of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University, Wuhan 430079, China. Electronic address:

Exposure to specific air pollutants has been demonstrated to induce damage in the brain. However, these studies ignore the effects of a combination of contaminants, and there is a high likelihood that people will be exposed to a mixture of contaminants in daily life. Our previous study showed that co-exposure to formaldehyde (FA) and PM2. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.01.048DOI Listing
January 2019
12 Reads

Acute effects of lipopolysaccharide (LPS) in kidney of rats and preventive role of vitamin E and sodium selenite.

Hum Exp Toxicol 2019 Jan 10:960327118817106. Epub 2019 Jan 10.

2 Department of Biology, Faculty of Arts and Science, Bozok University, Divanliyolu/Yozgat, Turkey.

Lipopolysaccharide (LPS) as an endotoxin forms part of the cell wall of gram-negative bacteria and is responsible for initiating an acute inflammation after entering the living tissue. In this study, male rats were divided into eight groups: control group, vitamin E (VE) treatment group (200 mg/kg body weight (b.w. Read More

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http://dx.doi.org/10.1177/0960327118817106DOI Listing
January 2019
3 Reads

Dermal exposure to nano-TiO induced cardiovascular toxicity through oxidative stress, inflammation and apoptosis.

J Toxicol Sci 2019 ;44(1):35-45

Laboratory of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, China.

Due to its excellent properties such as ultraviolet obscuration, chemical stability and small particle size, nano-titanium dioxide (nano-TiO) is widely used, particularly in sunblock products. The skin is therefore a chief route for exposure. Studies have found that oral or respiratory exposure to nano-TiO has an adverse impact on the cardiovascular system. Read More

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http://dx.doi.org/10.2131/jts.44.35DOI Listing
January 2019
9 Reads

[Testicular injury induced by DBP involved in activation of ERK pathway in KM mice].

Wei Sheng Yan Jiu 2018 Nov;47(6):956-962

Department of Internal Medicine, College of Clinical Medicine, Hubei University of Science and Technology, Xianning 437100, China.

Objective: To investigate the role of extracellular regulated protein kinase( ERK) pathway activation in the testicular injury induced by dibutyl phthalate( DBP) in KM mice.

Methods: A total of fifty-six male KM mice were randomly divided into 8 groups: control group, 50 mg/( kg·d) DBP group, 50 mg/( kg·d) vitamin E( VE)group, 2 mg/( kg·d) nimodipine( Ni) group, DBP + VE group, DBP + Ni group, Ni +VE group and DBP + Ni + VE group. After consecutive 28 days of treatment, the body weight, testis weight, organ coefficient and sperm density of mice were measured. Read More

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November 2018
2 Reads

Chemical composition and oral toxicity assessment of Anisophyllea boehmii kernel oil: Potential source of new edible oil with high tocopherol content.

Food Chem 2019 Apr 30;278:795-804. Epub 2018 Nov 30.

Laboratory of Biology of Plants and Microorganisms, Department of Biology, Faculty of Science, University Mohammed First, 717, 60000 Oujda, Morocco.

Anisophyllea boehmii is an indigenous and wild species in Burundi. Its fruits are edible and commercialized in local markets. This study investigates chemical quality, composition and toxicity test of A. Read More

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http://dx.doi.org/10.1016/j.foodchem.2018.11.112DOI Listing
April 2019
1 Read

Utilization of Vitamin E Analogs to Protect Normal Tissues While Enhancing Antitumor Effects.

Semin Radiat Oncol 2019 01;29(1):55-61

Division of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, AR.

Despite advances in radiation delivery techniques, side effects of radiation therapy due to radiation exposure of normal tissues are common and can limit the deliverable dose to tumors. Significant interests lie in pharmacologic modifiers that may protect against normal tissue toxicity from cancer treatment while simultaneously enhancing the tumor response to therapy. While no such treatments are available in the clinic, this is an area of active preclinical and clinical research. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10534296183008
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http://dx.doi.org/10.1016/j.semradonc.2018.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309800PMC
January 2019
6 Reads

Potential effects of different natural antioxidants on inflammatory damage and oxidative-mediated hepatotoxicity induced by gold nanoparticles.

Int J Nanomedicine 2018 23;13:7931-7938. Epub 2018 Nov 23.

Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia,

Objective: The objective of this study was to verify and confirm the oxidative-mediated hepatotoxicity, inflammatory liver damage, and oxidative stress induced by intraperitoneal administration of gold nanoparticles (GNPs) in vivo; characterize the effect of different natural antioxidants on these hazardous changes; and finally choose the most powerful antioxidant among these different natural antioxidants.

Methods: Ten-nanometer GNPs were dissolved in aqueous solution of 0.01% concentration. Read More

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http://dx.doi.org/10.2147/IJN.S171931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260143PMC
January 2019
2 Reads

Challenges and Opportunities of Nanotechnology as Delivery Platform for Tocotrienols in Cancer Therapy.

Front Pharmacol 2018 26;9:1358. Epub 2018 Nov 26.

Product Development and Advisory Services Division, Malaysian Palm Oil Board, Bandar Baru Bangi, Malaysia.

Plant-derived phytonutrients have emerged as health enhancers. Tocotrienols from the vitamin E family gained high attention in recent years due to their multi-targeted biological properties, including lipid-lowering, neuroprotection, anti-inflammatory, antioxidant, and anticancer effects. Despite well-defined mechanism of action as an anti-cancer agent, their clinical use is hampered by poor pharmacokinetic profile and low oral bioavailability. Read More

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http://dx.doi.org/10.3389/fphar.2018.01358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276840PMC
November 2018
2 Reads

Bufalin-loaded vitamin E succinate-grafted-chitosan oligosaccharide/RGD conjugated TPGS mixed micelles demonstrated improved antitumor activity against drug-resistant colon cancer.

Int J Nanomedicine 2018 15;13:7533-7548. Epub 2018 Nov 15.

Interventional Cancer Institute of Chinese Integrative Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, People's Republic of China,

Background: Multidrug resistance (MDR) is the major reason for the failure of chemotherapy in colon cancer. Bufalin (BU) is one of the most effective antitumor active constituents in Chansu. Our previous study found that BU can effectively reverse P-glycoprotein (P-gp)-mediated MDR in colon cancer. Read More

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https://www.dovepress.com/bufalin-loaded-vitamin-e-succinate
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http://dx.doi.org/10.2147/IJN.S170692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241863PMC
January 2019
2 Reads

Potential ability for metallothionein and vitamin E protection against cadmium immunotoxicity in head kidney and spleen of grass carp (Ctenopharyngodon idellus).

Ecotoxicol Environ Saf 2019 Apr 6;170:246-252. Epub 2018 Dec 6.

Department of Aquaculture, Sichuan Agricultural University, Wenjiang, Sichuan 611130, China.

Cadmium (Cd) pollution is an important issue affecting the food safety of aquatic products. Cd can impair the immune system and cause irreversible damage to fish and other aquatic organisms. The immunoprotection activities of exogenous metallothionein (MT) and vitamin E (VE) were investigated in Cd poisoned grass carp, Ctenopharyngodon idellus, in the present study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01476513183127
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http://dx.doi.org/10.1016/j.ecoenv.2018.11.134DOI Listing
April 2019
5 Reads

Antioxidant, intestinal immune status and anti-inflammatory potential of Chenopodium ambrosioides L. in fish: In vitro and in vivo studies.

Fish Shellfish Immunol 2019 Mar 28;86:420-428. Epub 2018 Nov 28.

Chemistry of Natural Products Laboratory, Biotechnology and Biochemistry Department, Centro de Investigación y de Estudios Avanzados del IPN (CINVESTAV-IPN), Irapuato, Gto., Mexico.

Chenopodium ambrosioides L. has been used for centuries as traditional medicine in many clinical situations. The objectives of this study were first to assess the nutraceutical potential of C. Read More

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http://dx.doi.org/10.1016/j.fsi.2018.11.059DOI Listing
March 2019
1 Read
2.674 Impact Factor

Codelivery of doxorubicin and elacridar to target both liver cancer cells and stem cells by polylactide-co-glycolide/d-alpha-tocopherol polyethylene glycol 1000 succinate nanoparticles.

Int J Nanomedicine 2018 25;13:6855-6870. Epub 2018 Oct 25.

Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China,

Purpose: Liver cancer is the third leading cause of cancer-related deaths worldwide. Liver cancer stem cells (LCSCs) are a subpopulation of cancer cells that are responsible for the initiation, progression, drug resistance, recurrence, and metastasis of liver cancer. Recent studies have suggested that the eradication of both LCSCs and liver cancer cells is necessary because the conversion of cancer stem cells (CSCs) to cancer cells occasionally occurs. Read More

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http://dx.doi.org/10.2147/IJN.S181928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207383PMC
December 2018
9 Reads

Role of flavonoid troxerutin on blood pressure, oxidative stress and regulation of lipid metabolism.

Front Biosci (Elite Ed) 2019 01 1;11:121-129. Epub 2019 Jan 1.

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India.

The objective of the present study was to investigate the effects of troxerutin (TX) on N-nitro-L-arginine methyl ester hydrochloride (L-NAME) induced hypertension in male albino Wistar rats. L-NAME (40mg/kg body weight (bw)) administration caused a sustained increase in systolic blood pressure (SBP), levels of thiobarbituric acid reactive substances (TBARS), lipid hydroperoxides (LOOH), tissue lipids (liver and kidney) such as total cholesterol (TC), triglycerides (TG), free fatty acids (FFA), and significant decrease in the activities of enzymatic antioxidants, phospholipids (PL) and levels of non enzymatic antioxidants such as reduced glutathione (GSH), vitamin C and vitamin E. To assess the toxicity if any of TX treatment, hepatic and renal function markers were measured. Read More

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January 2019
6 Reads

Bifenthrin exerts proatherogenic effects via arterial accumulation of native and oxidized LDL in rats: the beneficial role of vitamin E and selenium.

Environ Sci Pollut Res Int 2018 Nov 21. Epub 2018 Nov 21.

Laboratoire d'Ecophysiologie Animale, Faculté des Sciences de Sfax, 3018, Sfax, Tunisia.

The purpose of this study was to investigate, for the first time, the effects of Bifenthrin (Bif) chronic exposure on plasmatic and aortic lipid parameters disturbance and their pro-atherogenic possibility in Wistar rats. The ameliorative role of vitamin E (Vit E) and selenium (Se) were also targeted. Thus, rats were treated by gastric gavage with combination of Vit E (100 mg/kg/bw) and Se (0. Read More

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http://dx.doi.org/10.1007/s11356-018-3771-7DOI Listing
November 2018
5 Reads

The Protective Effect of α-Tocopherol on the Content of Selected Elements in the Calvaria for Exposed Hens to TCDD in the Early Embryonic Period.

Biol Trace Elem Res 2018 Nov 21. Epub 2018 Nov 21.

Polish Academy of Sciences, Institute of Low Temperature and Structure Research, Okolna 2, 50-422, Wroclaw, Poland.

This paper focuses on negative effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on element content in male chicken calvaria and α-tocopherol (vitamin E) ability to reduce its toxic potential on bone mineralization in offspring. In the experiment carried out once, a solution containing only DMSO, TCDD, TCDD + α-tocopherol, and exclusively α-tocopherol was administrated. Subsequently, on the 5th day after hatching, the mineral composition of the chicken calvaria was evaluated. Read More

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http://dx.doi.org/10.1007/s12011-018-1580-yDOI Listing
November 2018
10 Reads

Vitamin E-inspired multi-scale imaging agent.

Bioorg Med Chem Lett 2019 Jan 2;29(1):107-114. Epub 2018 Nov 2.

Department of Chemistry and Biochemistry, University of Windsor, Windsor, Ontario, Canada. Electronic address:

The production and use of multi-modal imaging agents is on the rise. The vast majority of these imaging agents are limited to a single length scale for the agent (e.g. Read More

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http://dx.doi.org/10.1016/j.bmcl.2018.10.052DOI Listing
January 2019
4 Reads

Synergistic potential of propolis and vitamin E against sub-acute toxicity of AlCl3 in Albino mice: in vivo study.

Physiol Res 2018 Oct 23. Epub 2018 Oct 23.

Department of Zoology, Lahore College for Women University, Lahore, Pakistan.

Current study evaluated the synergistic potential of propolis and Vitamin E against sublethal toxicity of aluminum chloride on different biochemical parameters and liver histology. Swiss albino mice (n=42) were randomly divided into five groups. Group I received 0. Read More

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October 2018
10 Reads

Predicting vitamin E and C consumption intentions and behaviors among factory workers based on protection motivation theory.

Environ Health Prev Med 2018 Oct 24;23(1):51. Epub 2018 Oct 24.

Environmental Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, P.O. Box: 6618634683, Sanandaj, Iran.

Background: Study of antioxidant vitamin consumption behavior, especially in high-risk groups with high exposure to toxic metals to reduce metal toxicity, is emphasized. This study aims to examine the structural relationships between knowledge, protection motivation theory constructs, and vitamin E and C consumption behavior among cement factory workers.

Methods: Protection motivation theory and food frequency questionnaires were completed by 420 factory workers. Read More

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https://environhealthprevmed.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12199-018-0742-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199700PMC
October 2018
13 Reads

Impacts of hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor (mesotrione) on photosynthetic processes in Chlamydomonas reinhardtii.

Environ Pollut 2019 Jan 4;244:295-303. Epub 2018 Oct 4.

Department of Biological Sciences, GRIL-TOXEN, Ecotoxicology of Aquatic Microorganisms Laboratory, Université du Québec à Montréal, Succ. Centre-Ville, Montréal, Québec, Canada. Electronic address:

Mesotrione, an herbicide increasingly found in aquatic systems due to its increased application frequency in corn fields, is an inhibitor of the p-hydroxyphenylpyruvate dioxygenase (HPPD), a key enzyme for plastoquinone-9, α-tocopherol and indirectly for carotenoid biosynthesis. The direct effect of mesotrione on plastoquinone-9 and α-tocopherol synthesis and their degradation rates are well documented, but few information exists on its action on photosynthetic processes under various light intensities. We therefore investigated the photosynthetic activity, energy dissipation processes, pigment composition and α-tocopherol content when Chlamydomonas reinhardtii were exposed to mesotrione for 24 h under low light condition and then the impacts of HL treatment (75 min) were also investigated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02697491183317
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http://dx.doi.org/10.1016/j.envpol.2018.09.121DOI Listing
January 2019
14 Reads

Spermatogenesis dysfunction induced by PM from automobile exhaust via the ROS-mediated MAPK signaling pathway.

Ecotoxicol Environ Saf 2019 Jan 13;167:161-168. Epub 2018 Oct 13.

Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400014 China; Department of Pediatric Urology Surgery, Children's Hospital of Chongqing Medical University, Chongqing 400014 China. Electronic address:

Long-term exposure to particulate matter 2.5 (PM) from automobile exhaust impairs spermatogenesis through oxidative stress injury, but the underlying mechanism is unknown. To investigate the toxic mechanism of PM-induced spermatogenesis impairment, we focused on the MAPK signaling pathway. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01476513183099
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http://dx.doi.org/10.1016/j.ecoenv.2018.09.118DOI Listing
January 2019
15 Reads
2.762 Impact Factor

A pH-sensitive prodrug strategy to co-deliver DOX and TOS in TPGS nanomicelles for tumor therapy.

Colloids Surf B Biointerfaces 2019 Jan 5;173:346-355. Epub 2018 Oct 5.

Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, China. Electronic address:

This work has presented a novel strategy for designing pH-sensitive TOS-H-DOX prodrug-loaded TPGS nanomicelles for co-delivery TOS and DOX to enhance tumor therapy and reduce the toxic side effects. DOX was covalently conjugated to the vitamin E succinate through hydrazone bond to produce an pH-sensitive prodrug TOS-H-DOX (amido bond as a control, TOS-A-DOX), which was responsive to the acidic environment in tumor cells, and the prodrugs were subsequently encapsulated in the core of TPGS nanomicelles via hydrophobic effects with a significant drug loading capacity. The pH-sensitive prodrug nanomicelles TOS-H-DOX/TPGS exhibited potent release of DOX in acidic media relative to the pH-insensitive prodrug nanomicelles TOS-A-DOX/TPGS, and further studies of their intracellular uptake and intracellular localization demonstrated that TOS-H-DOX/TPGS nanomicelles can be effectively taken up by cells and drugs can be released. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2018.10.012DOI Listing
January 2019
2 Reads

The effect of α-tocopherol and dithiothreitol in ameliorating emamectin benzoate cytotoxicity in human K562 cells involving the modulation of ROS accumulation and NF-κB signaling.

Ecotoxicol Environ Saf 2019 Jan 10;167:114-121. Epub 2018 Oct 10.

Shanghai Key Lab of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China. Electronic address:

Emamectin benzoate (EMB) toxicity contributes a potential risk to environment and human health. To investigate the effect of α-tocopherol (VitE) and dithiothreitol (DTT) in ameliorating EMB-induced cytotoxicity in human K562 cells, in vitro cultured human K562 cells were incubated with different concentrations of EMB in supplement with VitE and DTT when the cells were in the logarithmic phase. Next, the cell growth inhibition was evaluated using the MTT assay and cellular morphology observation. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2018.09.125DOI Listing
January 2019
1 Read

δ-Tocotrienol, Isolated from Rice Bran, Exerts an Anti-Inflammatory Effect via MAPKs and PPARs Signaling Pathways in Lipopolysaccharide-Stimulated Macrophages.

Int J Mol Sci 2018 Oct 4;19(10). Epub 2018 Oct 4.

Hunan Key Laboratory of Grain-Oil Deep Process and Quality Control, Hunan Key Laboratory of Processed Food for Special Medical Purpose, College of Food Science and Engineering, National Engineering Laboratory for Deep Process of Rice and Byproducts, Central South University of Forestry and Technology, Changsha 410004, Hunan, China.

δ-Tocotrienol, an important component of vitamin E, has been reported to possess some physiological functions, such as anticancer and anti-inflammation, however their molecular mechanisms are not clear. In this study, δ-tocotrienol was isolated and purified from rice bran. The anti-inflammatory effect and mechanism of δ-tocotrienol against lipopolysaccharides (LPS) activated pro-inflammatory mediator expressions in RAW264. Read More

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http://www.mdpi.com/1422-0067/19/10/3022
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http://dx.doi.org/10.3390/ijms19103022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212927PMC
October 2018
9 Reads

Safety Assessment of Tocopherols and Tocotrienols as Used in Cosmetics.

Int J Toxicol 2018 Sep/Oct;37(2_suppl):61S-94S

4 Cosmetic Ingredient Review Executive Director, Cosmetic Ingredient Review, Washington, DC, USA.

The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) assessed the safety of 14 tocopherols and tocotrienols and concluded these ingredients are safe as used in cosmetics. The tocopherols are reported to function in cosmetics as antioxidants or skin-conditioning agents; in contrast, tocotrienols are not reported to function as an antioxidants in cosmetics but as a light stabilizer, oral care agent, or skin-conditioning agent. The Panel reviewed the new and existing animal and clinical data to determine the safety of these ingredients and found it appropriate to extrapolate the existing information to conclude on the safety of all the tocopherols and tocotrienols. Read More

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http://dx.doi.org/10.1177/1091581818794455DOI Listing
February 2019
3 Reads
1.233 Impact Factor

Investigations on the interactions between curcumin loaded vitamin E TPGS coated nanodiamond and Caco-2 cell monolayer.

Int J Pharm 2018 Nov 14;551(1-2):177-183. Epub 2018 Sep 14.

College of Pharmacy, Liaoning University, Shenyang 110036, PR China. Electronic address:

This study aimed at investigating the potential mechanism of improved transportation of the curcumin loaded D-α-tocopherol polyethylene glycol 1000 succinate coated nanodiamonds system (NDs/CUR/TPGS complexes) using an in vitro Caco-2 cell monolayer model. The core-shell structured NDs/CUR/TPGS nanocomplexes were 196.32 ± 5. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03785173183068
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http://dx.doi.org/10.1016/j.ijpharm.2018.09.030DOI Listing
November 2018
8 Reads

Tocopherol-loaded transfersomes: In vitro antioxidant activity and efficacy in skin regeneration.

Int J Pharm 2018 Nov 7;551(1-2):34-41. Epub 2018 Sep 7.

Dept. of Scienze della Vita e dell'Ambiente, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy.

Transfersomes were prepared by using different polysorbates (i.e., Tween 20, 40, 60 and 80) and loaded with tocopherol acetate, a naturally-occurring phenolic compound with antioxidant activity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03785173183066
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http://dx.doi.org/10.1016/j.ijpharm.2018.09.009DOI Listing
November 2018
38 Reads

[Antagonistic effect of vitamin E on di-2-ethylhexyl phthalate-induced reproductive toxicity in male rats].

Zhonghua Nan Ke Xue 2018 Jul;24(7):589-595

Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.

Objective: To explore the antagonistic effect of vitamin E (VE) on male reproductive toxicity induced by di-2-ethylhexyl phthalate (DEHP) in pubertal SD rats and its underlying mechanisms.

Methods: Thirty 5-week-old male SD rats were randomly divided into five groups of equal number, corn oil control, low-dose (10 mg/kg/d), medium-dose (100 mg/kg/d) and high-dose DEHP exposure (500 mg/kg/d), and VE intervention (high-dose DEHP + VE [100 mg/kg/d]), and treated respectively for 30 successive days. At 3 days after treatment, the testes of the animals were harvested for determination of the oxidative stress index, serum reproductive hormone levels, cauda epididymal sperm parameters, and expressions of cell apoptosis-related genes and proteins. Read More

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July 2018
16 Reads

[The influence of methionine and vitamin E on oxidative stress in rats’ liver exposed to sodium fluoride]

Med Pr 2018 Aug 10;69(4):403-412. Epub 2018 Jul 10.

Śląski Uniwersytet Medyczny w Katowicach / Medical University of Silesia in Katowice, Zabrze, Poland (Wydział Lekarski z Oddziałem Lekarsko-Dentystycznym w Zabrzu, Katedra Biochemii / School of Medicine with the Division of Dentistry in Zabrze, Department of Biochemistry)

Background: Fluorine influences many processes occurring in the organism. Controversies over the evaluation of the biological effects of this substance are due to a small difference between tolerable and toxic fluorine doses. One of the main mechanisms of the fluorine toxic action is its ability to induce oxidative stress via reactive oxygen species generation and antioxidant defense system impairment. Read More

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http://dx.doi.org/10.13075/mp.5893.00706DOI Listing
August 2018
8 Reads

Effect of L. stigma (saffron) against subacute effect of diazinon: histopathological, hematological, biochemical and genotoxicity evaluations in rats.

J Pharmacopuncture 2018 Jun 30;21(2):61-69. Epub 2018 Jun 30.

Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: In this study, the effects of saffron stigma against subacute diazinon (DZN) toxicity on enzymes levels, biochemical, hematological, histopathological and genotoxicity indices were studied in rats.

Methods: Vitamin E (200 IU/kg) and the aqueous extract of saffron (50, 100 and 200 mg/kg) were injected intraperitoneally three times per week alone or with DZN (20 mg/kg/day, orally) for 4 weeks. The hematological and biochemical parameters were evaluated at the end of 4 weeks. Read More

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http://dx.doi.org/10.3831/KPI.2018.21.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054089PMC
June 2018
3 Reads

Adjunctive Treatments for the Prevention of Chemotherapy- and Radiotherapy-Induced Mucositis.

Integr Cancer Ther 2018 12 23;17(4):1027-1047. Epub 2018 Aug 23.

1 University of Sydney, Sydney, New South Wales, Australia.

Background: Chemoradiotherapy-associated mucositis can manifest as pain, inflammation, dysphagia, diarrhea, weight loss, rectal bleeding, and infection. Mucositis is a major dose-limiting side effect of chemotherapy, affecting nutritional intake and oral and intestinal function. Despite several interventions being available, there is a need for safe and effective preventative and treatment options for treatment-induced mucositis. Read More

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http://dx.doi.org/10.1177/1534735418794885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247548PMC
December 2018
23 Reads

The protective effects of a novel synthetic β-elemene derivative on human umbilical vein endothelial cells against oxidative stress-induced injury: Involvement of antioxidation and PI3k/Akt/eNOS/NO signaling pathways.

Biomed Pharmacother 2018 Oct 30;106:1734-1741. Epub 2018 Jul 30.

Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Longmian Avenue, 639, Nanjing, Jiangsu, 211198, China. Electronic address:

Antioxidant therapy is considered as promising strategy for treating oxidative stress-induced cardiovascular disease. Bis (β-elemene-13-yl) glutarate (BEG) is a novel β-elemene derivative. Herein, we examined the antioxidant activity of BEG on human umbilical vein endothelial cells (HUVECs) after injury with hydrogen peroxide (HO) and investigated the mechanism involved. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07533322183310
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http://dx.doi.org/10.1016/j.biopha.2018.07.107DOI Listing
October 2018
11 Reads

Bisphenol A vascular toxicity: Protective effect of Vitis vinifera (grape) seed extract and resveratrol.

Phytother Res 2018 Dec 16;32(12):2396-2407. Epub 2018 Aug 16.

Pharmaceutical Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

The underlying mechanism of Bisphenol A (BPA)-induced vascular toxicity and the protective role of grape seed extract (GSE) and resveratrol were investigated in vitro and in vivo. Human umbilical vein endothelial cells (HUVECs) were exposed to different concentrations of GSE and resveratrol. Then, BPA was added to the cells and cell viability and effects on the protein level of cell adhesion molecules were measured through MTT and western blotting. Read More

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http://dx.doi.org/10.1002/ptr.6175DOI Listing
December 2018
3 Reads

Protective effects of methanol extract of seeds and 4H-Pyran-4-One 2,3-Dihydro-3,5-Dihydroxy-6-Methyl on the reproductive function of male Wistar rats treated with cadmium chloride.

JBRA Assist Reprod 2018 Nov 1;22(4):289-300. Epub 2018 Nov 1.

Department of Physiology, University of Ibadan, Ibadan, Oyo State, Nigeria.

Objectives: Male infertility caused by exposure to heavy metals is a current global issue. Exposure to cadmium chloride (CdCl) negatively affects the male reproductive system. Many infertile people, especially in developing countries, resort to folkloric treatment. Read More

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http://www.gnresearch.org/doi/10.5935/1518-0557.20180048
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http://dx.doi.org/10.5935/1518-0557.20180048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210618PMC
November 2018
15 Reads

Antioxidant effects on the intracerebroventricular galactose damage in rats.

Pathol Res Pract 2018 Oct 3;214(10):1596-1605. Epub 2018 Aug 3.

Departamento de Medicina, Universidade da Região de Joinville- UNIVILLE, Rua Paulo Malschitzki, 10-Zona Industrial Norte, CEP 89201-972, Joinville, SC, Brazil; Programa de Pós-Graduação em Saúde e Meio Ambiente, Universidade da Região de Joinville- UNIVILLE, Rua Paulo Malschitzki, 10-Zona Industrial Norte, CEP 89201-972, Joinville, SC, Brazil. Electronic address:

We investigated the effects of the intracerebroventricular infusion of galactose and the influence of pretreatment with antioxidants on oxidative stress parameters and acethylcholinesterase (AChE) activity in the brain of 60-day-old Wistar rats (6 per group). The animals were divided into naïve group (did not undergo surgery); procedure group (only underwent surgery); sham group (underwent surgery and received 5 μL saline) and galactose group (received 5 μL of galactose solution (5.0 mM) by intracerebroventricular injection), and were killed by decapitation after 1 h. Read More

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http://dx.doi.org/10.1016/j.prp.2018.07.034DOI Listing
October 2018
12 Reads

Changes in glucose metabolism and mRNA expression of IRS-2 in rats exposed to phoxim and the protective effects of vitamin E.

Toxicol Res (Camb) 2018 Mar 1;7(2):201-210. Epub 2017 Dec 1.

Institute of Animal Nutrition , Northeast Agricultural University , Harbin , 150030 , P. R. China . Email: ; ; Tel: +86 0451 5519 0685.

Research has shown that organophosphorus pesticides impair glucose homeostasis and cause insulin resistance and type 2 diabetes. The current study investigates the influence of phoxim on insulin signaling pathways and the protective effects of vitamin E. Phoxim (180 mg kg) and VE (200 mg kg) were administered orally to Sprague-Dawley rats over a period of 28 consecutive days. Read More

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http://dx.doi.org/10.1039/c7tx00243bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061297PMC
March 2018
2 Reads

Methylmercury alters the number and topography of NO-synthase positive neurons in embryonic retina: Protective effect of alpha-tocopherol.

Toxicol In Vitro 2018 Dec 31;53:89-98. Epub 2018 Jul 31.

Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil. Electronic address:

Vertebrate retina has been shown to be an important target for mercury toxicity and very studies have shown the effect of mercury on the retinal ontogenesis. The nitrergic system plays an important role in the retinal development. The current work studied the effects of methylmercury (MeHg) exposure on the NO-synthase positive neurons (NADPH-diaphorase neurons or NADPH-d+) of the chick retinal ganglion cell layer at embryonic E15 and postnatal P1 days. Read More

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http://dx.doi.org/10.1016/j.tiv.2018.07.018DOI Listing
December 2018
21 Reads

Synergistic effect of glucosamine and vitamin E against experimental rheumatoid arthritis in neonatal rats.

Biomed Pharmacother 2018 Sep 18;105:835-840. Epub 2018 Jun 18.

Department of Pediatric Rheumatic Immunology, Wuhan Children's Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, China.

The effect of glucosamine and vitamin E against rheumatoid arthritis (RA) in a neonatal rat model was investigated. Lipid peroxidation, superoxide dismutase (SOD), catalase, reduced glutathione (GSH), glutathione peroxidase (Gpx), matrix metalloproteinase-3 (MMP-3), prostaglandin E (PGE), ceruloplasmin, copper, zinc, nitric oxide (NO), uric acid, inducible nitric oxide synthase (iNOS), and nuclear factor-kappaB (NF-κB) levels were determined in control and rheumatoid arthritis neonatal rats. Glucosamine plus vitamin E supplementation reduced the MDA level by 61. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.05.136DOI Listing
September 2018
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Multifunctional self-assembled micelles of galactosamine-hyaluronic acid-vitamin E succinate for targeting delivery of norcantharidin to hepatic carcinoma.

Carbohydr Polym 2018 Oct 31;197:194-203. Epub 2018 May 31.

Department of Pharmaceutics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China. Electronic address:

A polymer of Galactosamine-hyaluronic acid-Vitamin E succinate (Gal-HA-VES) was designed to prepare multifunctional self-assembled micelles for delivery of Norcantharidin (NCTD) to Hepatic carcinoma. NCTD/Gal-HA-VES showed higher cytotoxicity toward CD44-overexpressing MCF-7 cells, MCF-7/Adr cells and ASGP-R overexpressing HepG2 cells, consistent with the enhanced cellular uptake in the selected cell models, indicating Gal-HA-VES micelles were taken up in MCF-7 and HepG2 cells by CD44 and ASGPR receptor mediated endocytosis, respectively. Moreover, the accumulation of Rhodamine 123 demonstrated that Gal-HA-VES has the same action of TPGS as a P-glycoprotein inhibitor blocked drug efflux-related MDR mechanism in resistant MCF-7/Adr cells. Read More

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http://dx.doi.org/10.1016/j.carbpol.2018.05.090DOI Listing
October 2018
6 Reads

Vitamin E alleviates phoxim-induced toxic effects on intestinal oxidative stress, barrier function, and morphological changes in rats.

Environ Sci Pollut Res Int 2018 Sep 12;25(26):26682-26692. Epub 2018 Jul 12.

Institute of Animal Nutrition, Northeast Agricultural University, Harbin, 150030, People's Republic of China.

Phoxim is an organic phosphorus pesticide that remains easily in the environment, such as human food and animal feed. The objective of this study was to explore the effect of vitamin E on phoxim-induced oxidative stress in the intestinal tissues of Sprague-Dawley (SD) rats. Forty-eight Sprague-Dawley rats were randomly assigned to a control group and three treatment groups: treatment group 1 (phoxim: 20 mg/kg·BW), treatment group 2 (phoxim: 180 mg/kg·BW), and treatment 3 (vitamin E + phoxim: 200 mg/kg·BW + 180 mg/kg·BW). Read More

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http://dx.doi.org/10.1007/s11356-018-2666-yDOI Listing
September 2018
3 Reads

The hepatoprotective effect of lycopene on Con A-induced liver injury in mice.

Pharmazie 2018 07;73(7):393-395

Lycopene, the main fat-soluble pigment responsible for the red color of ripe tomatoes, is a symmetrical tetraterpene comprising eight isoprene units. In vitro and in vivo studies have shown that lycopene acts as a potent antioxidant; it is 100 times more effective than vitamin E and 125 times more effective than glutathione as an antioxidant. Here, we divided BALB/c male mice into three equal groups: control, Concanavalin A (Con A), and Con A and lycopene. Read More

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http://dx.doi.org/10.1691/ph.2018.8437DOI Listing
July 2018
1 Read

[Target delivery of small interfering RNAs with vitamin E- loaded lipid nanoparticles in inhibition of hepatitis C virus core protein expression in mouse model].

Zhonghua Gan Zang Bing Za Zhi 2018 May;26(5):382-387

Department of Infectious Disease, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.

To study the efficacy of vitamin E-loaded lipid nanoparticles (VE-DC) in the mouse model to target small interfering RNA (siRNA) for inhibition of hepatitis C virus(HCV) core protein expression. A high-pressure hydrodynamic method was adopted to construct an animal model of liver-specific expression to inject the plasmid containing HCV core protein into mice tail vein. Western blotting and immunofluorescence techniques were used to evaluote the liver targeting property of VE - DC/siRNA nanoparticles and the effectiveness to repress HCV Core expression. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1007-3418.2018.05.013DOI Listing
May 2018
10 Reads

Antiapoptotic effects of vitamins C and E against cypermethrin-induced oxidative stress and spermatogonial germ cell apoptosis.

J Biochem Mol Toxicol 2018 Aug 5;32(8):e22174. Epub 2018 Jul 5.

Reproductive Physiology Laboratory, Department of Zoology, Kurukshetra University, Kurukshetra, 136 119, India.

Toxicological studies have demonstrated the relation between use of agrochemicals and fertility issues within males. Thus, the present study aimed to elucidate the propensity of cypermethrin (CYP) in bringing testicular germ cell apoptosis and effective attenuation by vitamins C and E in caprines. Reproductive toxicity of CYP was evaluated using histomorphological, cytological, and biochemical changes in the testicular germ cells in dose-dependent (1, 5, 10 μg/mL) and time-dependent (4, 6, 8 h) manner. Read More

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http://dx.doi.org/10.1002/jbt.22174DOI Listing
August 2018
5 Reads

Mitigative role of garlic and vitamin E against cytotoxic, genotoxic, and apoptotic effects of lead acetate and mercury chloride on WI-38 cells.

Pharmacol Rep 2018 Aug 5;70(4):804-811. Epub 2018 Feb 5.

Genetics and Cytology Department, National Research Center, Dokki, Egypt; Common First Year Deanship, King Saud University, Riyadh, Saudi Arabia. Electronic address:

Background: Lead acetate (Led) and mercury chloride (Mer) represent important ecological and public health concerns due to their hazardous toxicities. Naturally found products play a vital role in chemopreventive agent innovation. The current study aimed to assess the modifying effect of garlic (Gar) and/or vitamin E (Vit E) against the half-maximal inhibitory concentration (IC50) Led and/or Mer-induced cytotoxic, genotoxic and apoptotic effects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17341140173073
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http://dx.doi.org/10.1016/j.pharep.2018.02.009DOI Listing
August 2018
2 Reads

Cytoprotective role of vitamin E in porcine adipose-tissue-derived mesenchymal stem cells against hydrogen-peroxide-induced oxidative stress.

Cell Tissue Res 2018 Oct 27;374(1):111-120. Epub 2018 Jun 27.

Department of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center-Campbell Clinic, Memphis, TN, USA.

Survival of mesenchymal stem cells (MSCs) against oxidative stress and inflammation is vital for effective stem cell therapy. The reactive oxygen species (ROS) result in apoptosis and release of inflammatory mediators. Adipose-derived stem cells (ASCs) have shown promise for stem cell therapy owing to their anti-inflammatory and anti-oxidant activity. Read More

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http://dx.doi.org/10.1007/s00441-018-2857-3DOI Listing
October 2018
12 Reads

Unified D-α-Tocopherol 5-Fu/SAHA bioconjugates self-assemble as complex nanodrug for optimized combination therapy.

Nanomedicine (Lond) 2018 06;13(11):1285-1301

Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 Wenhua Xi Road, Jinan 250012, Shandong, China.

Aim: To optimize the synergistic efficacy of combination therapy with controlled molar ratio, complex small molecule-based nanodrug (Co-SMND) of 5-fluorouracil (5-Fu)/vorinostat (SAHA) was developed.

Materials & Methods: Co-SMND with various ratios of 5-Fu-D-α-tocopherol (VE)/SAHA-VE were prepared and characterized including co-assembly mechanism, hydrolytic stability, cytotoxicity, synergistic effect and apoptosis inducing ability. The antitumor activity, systematic toxicity and biodistribution of optimized Co-SMND were evaluated in CT-26 bearing BALB/c mouse. Read More

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https://www.futuremedicine.com/doi/10.2217/nnm-2017-0316
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http://dx.doi.org/10.2217/nnm-2017-0316DOI Listing
June 2018
4 Reads

Arsenic-induced oxidative stress, cholinesterase activity in the brain of Swiss albino mice, and its amelioration by antioxidants Vitamin E and Coenzyme Q10.

Environ Sci Pollut Res Int 2018 Aug 8;25(24):23946-23953. Epub 2018 Jun 8.

Division of Reproductive and Cytotoxicology, ICMR- National Institute of Occupational Health, Meghani nagar, Ahmedabad, 380016, India.

Arsenic toxicity becomes one of the major public health issues in several countries. Chronic and acute exposure to arsenic has been reported to be toxic to various systems of the human body and also observed in controlled experimental studies. The study was conducted to evaluate the neurotoxic effect of arsenic in Swiss albino mice and its amelioration by Vitamin E, Coenzyme Q10 and their combination. Read More

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http://link.springer.com/10.1007/s11356-018-2398-z
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http://dx.doi.org/10.1007/s11356-018-2398-zDOI Listing
August 2018
10 Reads
2.830 Impact Factor

Protective but Non-Synergistic Effects of Nigella Sativa and Vitamin E against Cisplatin-Induced Renal Toxicity and Oxidative Stress in Wistar Rats.

Drug Res (Stuttg) 2018 Dec 26;68(12):696-703. Epub 2018 Jun 26.

Department of Pharmacology, Therapeutics and Toxicology , Lagos, Nigeria.

Background: Cisplatin is an anti-cancer drug that causes nephrotoxicity and oxidative stress. Extracts of Nigella sativa is nephroprotective. Vitamin E is also a potent antioxidant. Read More

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http://dx.doi.org/10.1055/a-0626-7003DOI Listing
December 2018
2 Reads

Vitamin E and vitamin C attenuate Di-(2-ethylhexyl) phthalate-induced blood-testis barrier disruption by p38 MAPK in immature SD rats.

Reprod Toxicol 2018 10 27;81:17-27. Epub 2018 Jun 27.

Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, China International Science and Technology Cooperation base of Child development and Critical Disorders, Chongqing, 400014, China; Department of Pediatric Urology Surgery, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China. Electronic address:

As an environmental endocrine disruptor, Di-(2-ethylhexyl) phthalate (DEHP) affects blood-testis barrier (BTB)-associated proteins expression, which compromises BTB integrity and causes infertility. Notably, DEHP-induced testicular toxicity is related to oxidative stress, but the specific mechanism remains unclear. Therefore, we sought to investigate this mechanism and determine whether vitamin C and vitamin E administration would attenuate the BTB impairment induced by DEHP in vivo and by Mono-(2-Ethylhexyl) Phthalate (MEHP) in vitro, respectively. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.06.015DOI Listing
October 2018
23 Reads

Nutritional, chemical and antioxidant/pro-oxidant profiles of silverskin, a coffee roasting by-product.

Food Chem 2018 Nov 21;267:28-35. Epub 2017 Mar 21.

REQUIMTE/LAQV, Department of Chemical Sciences, Faculty of Pharmacy of University of Porto, R. Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. Electronic address:

Coffee silverskin (a coffee roasting by-product) contains high amounts of dietary fibre (49% insoluble and 7% soluble) and protein (19%). Potassium (∼5g/100g), magnesium (2g/100g) and calcium (0.6g/100g) are the major macrominerals. Read More

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http://dx.doi.org/10.1016/j.foodchem.2017.03.106DOI Listing
November 2018
3 Reads