391,277 results match your criteria Vitamin E Toxicity


The Effect of Vitamin D Supplementation on Prostate Cancer: A Systematic Review and Meta-Analysis of Clinical Trials.

Horm Metab Res 2018 Dec 6. Epub 2018 Dec 6.

Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Vitamin D has received attention for its potential to disrupt cancer processes. However, its effect in the treatment of prostate cancer is controversial. This study aimed to assess the effect of vitamin D supplementation on patients with prostate cancer. Read More

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December 2018
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Effect of a cauliflower (Brassica oleraceae var. Botrytis) leaf powder-enriched diet on performance, carcass and meat characteristics of growing rabbit.

Meat Sci 2018 Nov 19;149:134-140. Epub 2018 Nov 19.

School of Agricultural, Forestry, Food and Environmental Sciences, University of Basilicata, Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy.

The aim of this study was to investigate the effect of a cauliflower leaf powder (CLP)-enriched diet on the performance, quality and antioxidative potential of rabbit meat. No significant differences were found for live performance parameters between rabbits fed with standard (SD) and CLP diet. Dietary supplementation influenced the meat traits of rabbits: CLP meat showed significantly lower drip loss after 48 h, cooking loss, and a significantly higher lightness (L*) and redness (a*) values, vitamin A and vitamin E content, and oxidative stability, compared to SD meat. Read More

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November 2018
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First ethnobotanical inventory and phytochemical analysis of plant species used by indigenous people living in the Maromizaha forest, Madagascar.

J Ethnopharmacol 2018 Dec 3. Epub 2018 Dec 3.

Department of Agriculture, Forestry and Food Science, University of Torino, Torino, Italy.

Ethnopharmacological Relevance: Characterized by one of the highest rates of endemism and biodiversity in the world, Madagascar provides a wide variety of medicinal plants, that could represent a potential source of new drugs. The main aim of this study was to investigate the potential medicinal properties of the plant species used by indigenous people in Maromizaha forest and to provide the first ethnobotanical inventory of the area.

Materials And Methods: Data were collected through open semi-structured interviews with local informants, the reported plants were collected and identified to create a specimen herbarium. Read More

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December 2018
3 Reads

Bioactivity of soy-based fermented foods: A review.

Biotechnol Adv 2018 Dec 3. Epub 2018 Dec 3.

College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China. Electronic address:

For centuries, fermented soy foods have been dietary staples in Asia and, now, in response to consumer demand, they are available throughout the world. Fermentation bestows unique flavors, boosts nutritional values and increases or adds new functional properties. In this review, we describe the functional properties and underlying action mechanisms of soy-based fermented foods such as Natto, fermented soy milk, Tempeh and soy sauce. Read More

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December 2018
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5- lipoxygenase (ALOX5): genetic susceptibility to type 2 diabetes and vitamin D effects on monocytes.

J Steroid Biochem Mol Biol 2018 Dec 3. Epub 2018 Dec 3.

Department of Internal Medicine I, Division of Endocrinology, Diabetes and Metabolism, Goethe University Hospital, Frankfurt am Main, Germany.

The arachidonate 5-lipoxygenase (ALOX5) pathway has been implicated in chronic inflammatory disease which may be influenced by vitamin D due to vitamin D response elements (VDRE). We investigated an ALOX5 polymorphism (rs4987105) in patients with type 2 diabetes (T2D) and the in vitro effects of calcitriol (1,25(OH)D) on ALOX5 metabolism in monocytes of T2D patients and healthy controls (HC). 533 T2D and 473 HC were genotyped for the rs4987105 polymorphism. Read More

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December 2018

Hydrogels with prolonged release of therapeutic antibody: Block junction chemistry modification of 'ABA' copolymers provides superior anticancer efficacy.

J Control Release 2018 Dec 3. Epub 2018 Dec 3.

31 Biopolis Way, The Nanos, 138669, Singapore. Electronic address:

In this study, we report a new series of vitamin E-functionalized 'ABA' triblock copolymers with carbamate block junction, which can form hydrogen-bonds. These polymers were synthesized via solvent- and catalyst-free nucleophilic addition between PEG-diamine and vitamin E-functionalized cyclic carbonate. The catalyst-free synthesis enabled an easy purification step and recycling of excess monomers. Read More

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December 2018
2 Reads

Acupuncture and related interventions for the treatment of symptoms associated with carpal tunnel syndrome.

Cochrane Database Syst Rev 2018 Dec 2;12:CD011215. Epub 2018 Dec 2.

School of Korean Medicine, Pusan National University, Beom-eu, Meulgeum, Yangsan, Korea, South, 626-870.

Background: Carpal tunnel syndrome (CTS) is a compressive neuropathic disorder at the level of the wrist. Acupuncture and other methods that stimulate acupuncture points, such as electroacupuncture, auricular acupuncture, laser acupuncture, moxibustion, and acupressure, are used in treating CTS. Acupuncture has been recommended as a potentially useful treatment for CTS, but its effectiveness remains uncertain. Read More

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December 2018
3 Reads

Rapid and substantial increases in anticoagulant use and expenditure in Australia following the introduction of new types of oral anticoagulants.

PLoS One 2018 6;13(12):e0208824. Epub 2018 Dec 6.

National Centre for Epidemiology and Population Health, Australian National University, Canberra, Australia.

Objectives: To quantify changes in anticoagulant use in Australia since the introduction of Non-vitamin K antagonist anticoagulants (NOACs) and to estimate government expenditure.

Design: Interrupted-time-series analysis quantifying anticoagulant dispensing, before and after first Pharmaceutical Benefits Scheme (PBS) NOAC listing in August 2009 for venous thromboembolism prevention; and expanded listing for stroke prevention in non-valvular atrial fibrillation (AF) in August 2013, up to June 2016. Estimated government expenditure on PBS-listed anticoagulants. Read More

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December 2018

Association of pre-eclampsia risk with maternal levels of folate, homocysteine and vitamin B12 in Colombia: A case-control study.

PLoS One 2018 6;13(12):e0208137. Epub 2018 Dec 6.

Farr Institute of Health Informatics, University College London, London, United Kingdom.

Background: Maternal serum concentrations of folate, homocysteine, and vitamin B12 have been associated with pre-eclampsia. Nevertheless, reported studies involve limited number of cases to reliably assess the nature of these associations. Our aim was to examine the relation of these three biomarkers with pre-eclampsia risk in a large Colombian population. Read More

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December 2018
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Comparative effectiveness of vitamin D supplementation via buccal spray versus oral supplements on serum 25-hydroxyvitamin D concentrations in humans: a systematic review protocol.

JBI Database System Rev Implement Rep 2018 Dec 3. Epub 2018 Dec 3.

The Institute of Health and Community, University of Plymouth and The University of Plymouth Centre for Innovations in Health and Social Care.

REVIEW QUESTION:: the questions of this review are. Read More

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December 2018

Thrombospondin-1 and Vitamin D in Children With Sickle Cell Anemia.

J Pediatr Hematol Oncol 2018 Dec 4. Epub 2018 Dec 4.

Department of Pediatrics, Faculty of Medicine, Kuwait University, Kuwait.

Background: Thrombospondin-1 (TSP-1) and 25-hydroxyvitamin D (25-OHD) play significant roles in the pathogenesis of sickle cell anemia (SCA). TSP-1 enhances cellular adhesion/inflammation, hence contributing to vaso-occlusive crisis (VOC); vitamin D, in contrast, retards inflammation and may lower rate of pain episodes. We determined serum levels of TSP-1 and 25-OHD in Nigerian children with SCA and their matched hemoglobin AA controls; and assess the relationship between the 2 biomarkers. Read More

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December 2018

Linkages between epithelial microbiota and host transcriptome in the ileum during high grain challenges: implications for gut homeostasis in goats.

J Agric Food Chem 2018 Dec 6. Epub 2018 Dec 6.

A high-grain diet (HG) can result in ruminal subacute acidosis, which is detrimental to gut health and can lead to decreased productivity. This study investigated the ileal epithelial microbiota and its relationship with host epithelial function in goats fed an HG diet (concentrate: hay, 90: 10) and a Control diet (concentrate: hay, 55: 45) aiming to elucidate the mechanisms involved in ileal adaptation to subacute acidosis. The HG challenge increased ileal volatile fatty acid concentration (P = 0. Read More

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December 2018
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Hollow Fiber Countercurrent Dialysis for Continuous Buffer Exchange of High Value Biotherapeutics.

Biotechnol Prog 2018 Dec 6. Epub 2018 Dec 6.

Department of Chemical Engineering, The Pennsylvania State University, University Park, PA, 16802.

Buffer exchange, desalting, and formulation of high value biotherapeutics are currently performed using batch diafiltration; however, this type of tangential flow filtration process may be difficult to implement as part of a fully continuous biomanufacturing process. The objective of this study was to explore the potential of using countercurrent dialysis for continuous protein formulation and buffer exchange. Experiments were performed using concentrated solutions of Immunoglobuin G (IgG) with commercially available hollow fiber dialyzers having 1. Read More

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December 2018
5 Reads

Target discovery for new antitubercular drugs using a large dataset of growth inhibitors from PubChem.

Authors:
Robert C Goldman

Infect Disord Drug Targets 2018 Dec 5. Epub 2018 Dec 5.

Drug Discovery and Development, RCG Consulting, 16024 Golden Lakes Drive. United States.

The number of drugs available for treatment of active tuberculosis are diminishing due to increased multidrug resistance selection in Mycobacterium tuberculosis leading to multiple (MDR) and extensively (XDR) resistant strains. Also, TB is treated with multiple drugs to minimize further resistance development, mandating a sustained effort to identify new lead compounds for treating drug resistant TB, and shortening time to cure for all TB infections. High throughput screening, a well-known approach to discovery of new leads, is conducted in two basic modes 1) using whole cells and screening for inhibition of growth, or whole cell reporter cells that signals when a specific pathway is perturbed, and 2) in vitro non-cell based enzyme or other functional assays for direct ligand-target binding. Read More

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December 2018

Direct Oral Anticoagulants and Travel-related Venous Thromboembolism.

Open Med (Wars) 2018 27;13:575-582. Epub 2018 Nov 27.

Division of Hematology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Ext 80252, Thailand.

Travel- related thromboembolism reflects the relationship between venous thromboembolism (VTE) and long-haul flights. Although this condition is rare, it may cause significant morbidity and mortality. Therefore, travelers should be evaluated for the risks for thrombosis. Read More

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November 2018

The Effect of Vitamin E and Metallothionein on the Antioxidant Capacities of Cadmium-Damaged Liver in Grass Carp .

Biomed Res Int 2018 4;2018:7935396. Epub 2018 Nov 4.

Department of Aquaculture, College of Animal Science & Technology, Sichuan Agricultural University, WenJiang 611130, Sichuan, China.

Cadmium (Cd) causes a broad spectrum of toxicological effects to animals. Aquatic animals were more likely to accumulate Cd than terrestrial animals because of the living environment. Clearance of Cd in aquatic animals has become an important part of aquatic food safety. Read More

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November 2018

Pernicious Anemia Presented with Isolated Nominal Dysphasia in Type Ill Polyglandular Failure Female Patient.

Cureus 2018 Sep 14;10(9):e3306. Epub 2018 Sep 14.

Medicine, Xavier University School of Medicine, Oranjestad, ABW.

Pernicious anemia (also known as Biermer's disease) is an autoimmune atrophic gastritis which predominantly affects the fundus of the stomach. It results in a deficiency of vitamin B12 (cobalamin) as it affects the normal process of absorption in the ileum. The pernicious anemia is characterized by a wide range of hematological and neurological features. Read More

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September 2018

Denosumab-Induced Severe Hypocalcaemia in Chronic Kidney Disease.

Case Rep Nephrol 2018 4;2018:7384763. Epub 2018 Nov 4.

Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia.

Background: Hypocalcaemia is increasingly recognized as a complication of denosumab use in Chronic Kidney Disease (CKD) patients with osteoporosis. Despite Therapeutic Goods Administration (TGA) notifications in 2013, we have subsequently encountered several cases of denosumab-induced hypocalcaemia, raising concern about lack of widespread awareness among prescribing practitioners.

Aims: We reviewed the morbidity and healthcare intervention needs of CKD patients with hypocalcaemia attributed to denosumab. Read More

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November 2018
2 Reads

The use of distortion product otoacoustic emissions (DPOAE) records to estimate effect of vitamin B complex on changing severity of tinnitus.

Ann Med Surg (Lond) 2018 Dec 5;36:203-211. Epub 2018 Nov 5.

AL-Karama Teaching Hospital, College of Medicine, Wasit University, Iraq.

Introduction: Patients that are complaining from tinnitus but have normal hearing comprise an uncommon group and there is rare literature about them. Deficiency in B-complex vitamins has been shown to result in tinnitus and supplementation may improve the symptom which means manipulation of cochlear status. Distortion Product Otoacoustic emissions (DPOAEs) used frequently to assess cochlear status. Read More

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December 2018

The effects of vitamin D supplementation on endothelial activation among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials.

Nutr Metab (Lond) 2018 29;15:85. Epub 2018 Nov 29.

4Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IR Iran.

Background And Objective: The current systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the effect of vitamin D supplementation on endothelial activation among patients with metabolic syndrome and related disorders.

Methods: Cochrane library, Embase, PubMed, and Web of Science database were searched to identify related RCTs published before 30th April 2018. The heterogeneity among the included studies was assessed using Cochran's Q test and I-square (I) statistic. Read More

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November 2018

Spontaneous Pathological Complete Regression of Hepatocellular Carcinoma.

Case Rep Gastroenterol 2018 Sep-Dec;12(3):653-659. Epub 2018 Nov 14.

Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.

Several possible mechanisms for spontaneous regression of hepatocellular carcinoma (HCC) have been reported. Spontaneous complete regression of HCC is extremely rare. We herein report a case of spontaneous pathological complete regression of HCC following decrement of elevated serum alpha-fetoprotein (AFP). Read More

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November 2018
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Impact of physical activity and sleep quality on quality of life of rural residents with and without a history of cancer: findings of the Day and Night Study.

Cancer Manag Res 2018 9;10:5525-5535. Epub 2018 Nov 9.

Department of Nutritional Sciences, Pennsylvania State University, University Park, PA, USA.

Background: Lifestyle behaviors may impact quality of life (QoL). The relative impact of physical activity and sleep quality on QoL of individuals with and without a history of cancer living in underserved rural communities requires further study to inform health care and public health initiatives.

Methods: Individuals with and without a history of cancer were recruited from rural Virginia. Read More

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November 2018

UBIAD1 suppresses the proliferation of bladder carcinoma cells by regulating H-Ras intracellular trafficking via interaction with the C-terminal domain of H-Ras.

Cell Death Dis 2018 Dec 5;9(12):1170. Epub 2018 Dec 5.

Department of Genetics and Developmental Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.

UbiA prenyltransferase domain-containing protein 1 (UBIAD1) plays a key role in biosynthesis of vitamin K and coenzyme Q10 using geranylgeranyl diphosphate (GGPP). However, the mechanism by which UBIAD1 participates in tumorigenesis remains unknown. This study show that UBIAD1 interacts with H-Ras, retains H-Ras in the Golgi apparatus, prevents H-Ras trafficking from the Golgi apparatus to the plasma membrane, blocks the aberrant activation of Ras/MAPK signaling, and inhibits the proliferation of bladder cancer cells. Read More

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December 2018
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Risk Profile and 1-Year Outcome of Newly Diagnosed Atrial Fibrillation in Japan - Insights From GARFIELD-AF.

Circ J 2018 Dec 4. Epub 2018 Dec 4.

Thrombosis Research Institute.

Background: Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective non-interventional study of stroke prevention in patients with newly diagnosed non-valvular AF (NAVF) that is being conducted in 35 countries. Methods and Results: A total of 52,081 patients with a new diagnosis of NVAF were enrolled prospectively in GARFIELD-AF. Of these, 4859 (9. Read More

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December 2018

Hybrid prevalence estimation: Method to improve intervention coverage estimations.

Proc Natl Acad Sci U S A 2018 Dec 5. Epub 2018 Dec 5.

Department of International Public Health, Liverpool School of Tropical Medicine, L3 5QA Liverpool, United Kingdom;

Delivering excellent health services requires accurate health information systems (HIS) data. Poor-quality data can lead to poor judgments and outcomes. Unlike probability surveys, which are representative of the population and carry accuracy estimates, HIS do not, but in many countries the HIS is the primary source of data used for administrative estimates. Read More

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December 2018

[Paraffin oil injecions due to bigorexia may cause hypercalcaemia].

Ugeskr Laeger 2018 Nov;180(48)

Paraffin oil injections may cause severe hypercalcaemia, likely due to development of granulomas at injection sites, activating 1,25 dihydroxyvitamin D and increasing calcium uptake from gut, kidney and bone. This is a case report of a 39-year-old male with severe hypercalcaemia and renal failure due to paraffin oil injections. He was treated with prednisolone (25-50 mg daily), but the disease recurred the next two summers probably due to erroneous vitamin D supplement and sun exposure. Read More

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November 2018
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Higher dietary magnesium intake is associated with lower body mass index, waist circumference and serum glucose in Mexican adults.

Nutr J 2018 Dec 5;17(1):114. Epub 2018 Dec 5.

National Council of Science and Technology (CONACYT) - Center for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Morelos, Mexico.

Background: Obesity and diabetes mellitus (DM) are public health concerns in Mexico of top-level priority due to their high prevalence and their growth rate in recent decades. The accumulation of adipose tissue leads to an unbalanced release of pro-oxidant factors, which causes cellular damage and favors the development of comorbidities. Recent evidence suggests that oxidative stress also promotes the accumulation of adipose tissue and the development of insulin resistance. Read More

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December 2018

Prenatal exposure to phthalates and autism spectrum disorder in the MARBLES study.

Environ Health 2018 Dec 5;17(1):85. Epub 2018 Dec 5.

Department of Public Health Sciences, University of California, Davis, California, USA.

Background: Evidence from experimental and observational studies suggests that prenatal phthalate exposures may be associated with autism spectrum disorder (ASD). We examined whether prenatal phthalate exposures were associated with an increased risk of ASD.

Methods: We quantified 14 metabolites of eight phthalates in 636 multiple maternal urine samples collected during 2nd and 3rd trimesters of pregnancy from 201 mother-child pairs in MARBLES (Markers of Autism Risk in Babies - Learning Early Signs), a high-risk ASD longitudinal cohort. Read More

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December 2018

Vitamin D status in Kancheepuram District, Tamil Nadu, India.

BMC Public Health 2018 Dec 5;18(1):1345. Epub 2018 Dec 5.

SRM Institute of Gastroenterology, Hepatobiliary Sciences & Transplantation, SIMS Hospital, Jawaharlal Nehru Road, Vadapalani, Chennai, Tamil Nadu, India.

Background: Vitamin D has multifarious roles in maintenance of health and prevention of disease. The present study was undertaken to assess the vitamin D status of a rural adult south Indian population and to identify its associations with socioeconomic status and cultural practices.

Methods: Between June 2015 and July 2016, 424 healthy adults residing in Kattankulathur block in Tamil Nadu, India, provided venous blood samples and answered questions by personal interview. Read More

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December 2018
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Evaluation of Saccule Function in Patients with Vitamin D Deficiency.

J Audiol Otol 2018 Dec 7. Epub 2018 Dec 7.

Departments of Audiology, Faculty of Rehabilitation, Isfahan University of Medical Sciences, Isfahan, Iran.

Background And Objectives: : Considering important role of vitamin D in many physiological processes including vestibular system in the ear, aim of present study is to evaluate saccule function via cervical vestibular evoked myogenic potential (cVEMP), in patients with vitamin D deficiency.

Subjects And Methods: : After routine audiological tests, cVEMP were recorded in 15 patients with vitamin D deficiency and 16 normal subjects. The short tone burst (95 dB nHL, 500 Hz) was presented to ears. Read More

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December 2018
2 Reads

Vitamin E Metabolic Effects and Genetic Variants: A Challenge for Precision Nutrition in Obesity and Associated Disturbances.

Nutrients 2018 Dec 4;10(12). Epub 2018 Dec 4.

Laboratory of Molecular Biology, Nutrition and Biotechnology, NUO Group, Universitat de les Illes Balears, 07122 Palma, Spain.

Vitamin E (VE) has a recognized leading role as a contributor to the protection of cell constituents from oxidative damage. However, evidence suggests that the health benefits of VE go far beyond that of an antioxidant acting in lipophilic environments. In humans, VE is channeled toward pathways dealing with lipoproteins and cholesterol, underlining its relevance in lipid handling and metabolism. Read More

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December 2018

Dietary Composition and Cardiovascular Risk: A Mediator or a Bystander?

Nutrients 2018 Dec 4;10(12). Epub 2018 Dec 4.

Second Department of Internal Medicine and Research Institute, University General Hospital Attikon, 124 62 Haidari, Greece.

The role of nutrition in the pathogenesis of cardiovascular disease has long been debated. The established notion of the deleterious effects of fat is recently under question, with numerous studies demonstrating the benefits of low-carbohydrate, high-fat diets in terms of obesity, diabetes, dyslipidemia, and metabolic derangement. Monounsaturated and polyunsaturated fatty acids, especially -3 PUFAs (polyunsaturated fatty acids), are the types of fat that favor metabolic markers and are key components of the Mediterranean Diet, which is considered an ideal dietary pattern with great cardioprotective effects. Read More

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December 2018

Changes in Dietary Intake and Adherence to the NU-AGE Diet Following a One-Year Dietary Intervention among European Older Adults-Results of the NU-AGE Randomized Trial.

Nutrients 2018 Dec 4;10(12). Epub 2018 Dec 4.

Division of Human Nutrition, Wageningen University & Research, Wageningen, P.O. Box 17, 6700 AA Wageningen, The Netherlands.

Background: The Mediterranean Diet has been proposed as an effective strategy to reduce inflammaging, a chronic low grade inflammatory status, and thus, to slow down the aging process. We evaluated whether a Mediterranean-like dietary pattern specifically targeting dietary recommendations of people aged over 65 years (NU-AGE diet) could be effective to shift dietary intake of older adults towards a healthful diet.

Methods: Adults aged 65⁻80 years across five EU-centers were randomly assigned to a NU-AGE diet group or control group. Read More

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December 2018
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[Current Developments in Nutritional Therapy of Intensive Care Patients].

Dtsch Med Wochenschr 2018 Dec 3;143(24):1759-1764. Epub 2018 Dec 3.

Medizinische Klinik III (Gastroenterologie, Stoffwechselerkrankungen und Internistische Intensivmedizin) Universitätsklinikum, RWTH-Aachen.

The goals of nutritional therapy for critically ill patients are the enteral or parenteral provision of calories, proteins, electrolytes, vitamins, trace elements and fluids. The metabolism of critically ill patients is characterized by a catabolic stress condition, which is caused by a systemic inflammatory response and is associated with an increased infection rate, occurrence of multiple organ failure and increased mortality.Traditionally, nutritional therapy has been considered as an "adjunctive" therapy for critically ill patients with the primary goal of providing energy to maintain muscle mass. Read More

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December 2018

Dimethyl fumarate and vitamin D derivatives cooperatively enhance VDR and Nrf2 signaling in differentiating AML cells in vitro and inhibit leukemia progression in a xenograft mouse model.

J Steroid Biochem Mol Biol 2018 Nov 30. Epub 2018 Nov 30.

Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, 84105 Beer Sheva, Israel. Electronic address:

Acute myeloid leukemia (AML) is one of the deadliest hematological malignancies without effective treatment for most patients. Vitamin D derivatives (VDDs) - active metabolites 1α,25-dihydroxyvitamin D (1,25D2) and 1α,25-dihydroxyvitamin D (1,25D3) and their analogs - are differentiation-inducing agents which have potential for the therapy of AML. However, calcemic toxicity of VDDs limits their clinical use at doses effective against cancer cells in vivo. Read More

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November 2018
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Association between serum 25-hydroxyvitamin D levels and self-reported chronic pain in older adults: a cross-sectional analysis from the ViDA study.

J Steroid Biochem Mol Biol 2018 Nov 30. Epub 2018 Nov 30.

School of Population Health, The University of Auckland, Auckland, New Zealand. Electronic address:

Chronic pain is a major contributor to the global burden of disability. Prior studies on the association between serum 25-hydroxyvitamin D (25(OH)D) levels and chronic pain have yielded mixed results. The Vitamin D Assessment study, a large randomized controlled trial from New Zealand, offered the opportunity to examine this association in data collected at baseline in all participants, and among those with arthritis or depression. Read More

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November 2018

PARTICIPATION OF VITAMIN D-UPREGULATED PROTEIN 1 (TXNIP)-ASK1-JNK1 SIGNALOSOME IN THE ENHANCEMENT OF AML CELL DEATH BY A POST-CYTOTOXIC DIFFERENTIATION REGIMEN.

J Steroid Biochem Mol Biol 2018 Nov 30. Epub 2018 Nov 30.

Department of Pathology & Laboratory Medicine, Rutgers NJ Medical School, Newark, NJ, United States. Electronic address:

Standard therapy for Acute Myeloid Leukemia (AML) is rarely curative, and several suggested improvements have had little success so far. We have reported that in an in vitro model of a potential therapeutic regimen for AML, the activity of cytarabine (AraC) is enhanced by a sequential treatment with a combination of the vitamin D2 analog Doxercalciferol (D2) and the plant-derived antioxidant carnosic acid (CA) Importantly, the enhancement occurred selectively in patient-derived AML blasts, but not in the normal bone marrow cells. We now demonstrate that TXNIP, previously known as Vitamin D up-regulated protein 1 (VDUP1) [PMID 808674] plays a part in signaling cell death (CD) in this regimen. Read More

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November 2018
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Cross-sectional associations of vitamin D status with asthma prevalence, exacerbations, and control in New Zealand adults.

J Steroid Biochem Mol Biol 2018 Nov 30. Epub 2018 Nov 30.

School of Population Health, The University of Auckland, Auckland, New Zealand. Electronic address:

Background: Previous studies, mostly with children, have reported inconsistent findings on the associations of vitamin D status with asthma prevalence, exacerbations, and control. Because of limited research with adults, we examined these associations in a large community-based sample of New Zealand adults.

Methods: 5110 participants, aged 50-84 years, were recruited from the community into a clinical trial of vitamin D supplementation. Read More

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November 2018

Increased plasma levels of the lipoperoxyl radical-derived vitamin E metabolite α-tocopheryl quinone are an early indicator of lipotoxicity in fatty liver subjects.

Free Radic Biol Med 2018 Nov 30. Epub 2018 Nov 30.

Department of Pharmaceutical Science, University of Perugia, Perugia, Italy. Electronic address:

Lipid peroxidation is one of the earliest pathogenic events of non-alcoholic fatty liver disease (NAFLD). In this context, an increased oxidation of the lipoperoxyl radical scavenger α-tocopherol (α-TOH) should occur already in the subclinical phases of the disease to compensate for the increase oxidation of the lipid excess of liver and possibly of other tissues. However, this assumption remains unsupported by direct analytical evidence. Read More

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November 2018

Circulating Gas6 is associated with reduced human carotid atherosclerotic plaque burden in high risk cardiac patients.

Clin Biochem 2018 Dec 1. Epub 2018 Dec 1.

Department of Medicine, Division of Cardiology, Cardiovascular Imaging Network at Queen's, Queen's University, Kingston, Ontario, Canada; Department of Biomedical and Molecular Science, Queen's University, Kingston, Ontario, Canada. Electronic address:

Objective: Pre-clinical studies suggest that growth arrest-specific protein 6 (Gas6), a member of the vitamin K dependent family of proteins, is implicated in atherosclerosis. A role for Gas6 in stabilizing atherosclerotic plaque has been suggested. Our aim was to determine the association between Gas6 and measures of carotid artery atherosclerosis in humans undergoing elective coronary angiography. Read More

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December 2018

Mineral homeostasis in murine fetuses is sensitive to maternal calcitriol, but not to absence of fetal calcitriol.

J Bone Miner Res 2018 Dec 3. Epub 2018 Dec 3.

Faculty of Medicine - Endocrinology, Memorial University of Newfoundland, St. John's, NL, Canada.

Vitamin D receptor (VDR) null fetuses have normal serum minerals, PTH, skeletal morphology and mineralization, but increased serum calcitriol, placental calcium transport, and placental expression of Pthrp, Trpv6, and (as reported in this study) Pdia3. We examined Cyp27b1 null fetal mice, which do not make calcitriol, to determine if loss of calcitriol has the same consequences as loss of VDR. Cyp27b1 null and WT females were mated to Cyp27b1 males, which generated Cyp27b1 null and Cyp27b1 fetuses from Cyp27b1 null mothers, and Cyp27b1 and WT fetuses from WT mothers. Read More

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December 2018
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Dietary vitamin and mineral intakes in a sample of pregnant women with either gestational diabetes or type 1 diabetes mellitus, assessed in comparison with Polish nutritional guidelines.

Ginekol Pol 2018 ;89(11):581-586

1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Warsaw, Poland.

Objectives: Maintaining proper nutrition during pregnancy is crucial for pregnant women and especially for who have been diagnosed with type 1 diabetes mellitus (T1DM) or who develop gestational diabetes mellitus (GDM).

Material And Methods: To measure differences in vitamin and mineral intakes among women with normal pregnancies, pregnant women with GDM, and pregnant women with pre-gestational T1DM; and to assess the women's dietary intakes in comparison with Polish nutritional guidelines. The analysis was conducted among 83 pregnant women (29 GDM patients, 26 T1DM patients and 28 normal pregnancy participants) from whom we collected seven-day 24-hour dietary records during the second part of their pregnancies. Read More

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January 2018
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Vitamin D and overall cancer risk and cancer mortality: a Mendelian randomization study.

Hum Mol Genet 2018 Dec;27(24):4315-4322

QIMR Berghofer Medical Research Institute, Brisbane, Australia.

There is considerable debate regarding the role that 25-hydroxyvitamin D [25(OH)D] concentrations play in cancer risk or mortality, with earlier studies drawing mixed conclusions. Using data from the UK Biobank (UKB), we evaluate whether genetically predicted 25(OH)D concentrations are associated with overall cancer susceptibility and cancer mortality using five 25(OH)D genetic markers. Data comprised 438 870 white British UKB participants aged 37-73, including 46 155 cancer cases and 6998 cancer-specific deaths. Read More

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December 2018

The importance of time in therapeutic range in switching from vitamin K antagonist to non-vitamin K antagonist oral anticoagulants in atrial fibrillation.

Europace 2018 Dec 1. Epub 2018 Dec 1.

Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 3, København Ø, Denmark.

Aims: Patients with non-valvular atrial fibrillation (NVAF) receiving vitamin K antagonists (VKAs) with time in therapeutic international normalized ratio (INR) range (TTR) <70%, despite good adherence, are by guidelines recommended to switch to non-VKA oral anticoagulants (NOACs). The aim was to assess if patients are switched from VKA to NOAC when TTR is <70% in a real-world setting.

Methods And Results: Non-valvular atrial fibrillation patients receiving VKA (1 January 2010 to 31 December 2012) were identified in nationwide registries. Read More

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December 2018

2018 Update on Medical Overuse.

JAMA Intern Med 2018 Dec 3. Epub 2018 Dec 3.

Department of Medicine and Center for Health Policy and Outcomes, Memorial Sloan Kettering Cancer Center, New York, New York.

Importance: Overuse of medical care is a well-recognized problem in health care, associated with patient harm and costs. We sought to identify and highlight original research articles published in 2017 that are most relevant to understanding medical overuse.

Observations: A structured review of English-language articles published in 2017 was performed, coupled with examination of tables of contents of high-impact journals to identify articles related to medical overuse in adult care. Read More

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December 2018
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Preventing the development of asthma: stopping the allergic march.

Curr Opin Allergy Clin Immunol 2018 Nov 29. Epub 2018 Nov 29.

Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Purpose Of Review: To describe important precipitants of asthma and allergic disease, to highlight the links between these triggers and modifications within the immune system, and to examine innovative research regarding asthma prevention with focus on attenuating the atopic march.

Recent Findings: Allergen avoidance, allergen immunotherapy, IgE antagonists, prevention and treatment of respiratory infections, as well as management of gastrointestinal and respiratory dysbiosis have been considered as strategies in asthma prevention. Antenatal vitamin D supplementation in expectant mothers and aggressive control of atopic dermatitis to prevent the development of other allergic conditions were carefully studied as well. Read More

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November 2018

Benefits of multiple micronutrient supplementation in heart failure: A comprehensive review.

Crit Rev Food Sci Nutr 2018 Dec 3:1-17. Epub 2018 Dec 3.

d Department of Cardiology, Discipline of Cardiology II , "Victor Babes" University of Medicine and Pharmacy , Timisoara , Romania.

Background: Multiple micronutrient supplementation has been suggested to have a role on health outcomes in patients with heart failure (HF), but the evidence is inconclusive.

Objective: To elucidate the role of multiple micronutrient supplementation in heart failure we performed a comprehensive review of the literature.

Methods And Results: The search in databases included PUBMED (until June 2018) to detect randomized controlled trials (RCTs) and meta-analyzes that investigated the impact of micronutrient supplementation in HF. Read More

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December 2018
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Acute liver failure in two dogs following ingestion of cheese tree (Glochidion ferdinandi) roots.

J Vet Emerg Crit Care (San Antonio) 2018 Dec 2. Epub 2018 Dec 2.

University Veterinary Teaching Hospital, Sydney, Australia.

Objective: To describe the management and resolution of acute liver failure (ALF) in two dogs following ingestion of cheese tree (Glochidion ferdinandi) roots.

Case Summaries: A 2-year-old male entire Bullmastiff and a 5-year-old female neutered German Shepherd dog were presented for acute-onset lethargy and vomiting after chewing on tree roots of a cheese tree. Both dogs developed clinical abnormalities consistent with ALF, including hepatic encephalopathy, marked increase in alanine aminotransferase activity and bilirubin concentration, and prolonged coagulation times. Read More

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December 2018