4,021 results match your criteria Vitamin E Toxicity


A Novel Vitamin E TPGS-Based Formulation Enhances Chlorhexidine Bioavailability in Corneal Layers.

Pharmaceutics 2020 Jul 8;12(7). Epub 2020 Jul 8.

Department of Medicine and Health Science, "V. Tiberio" University of Molise, 86100 Campobasso, Italy.

Keratitis is a severe condition characterized by inflammation of the cornea following a local trauma. The most common ocular disease is the bacterial one, which requires an antibiotic treatment. The major limitation of this therapy is the resistance of the antibiotic. Read More

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http://dx.doi.org/10.3390/pharmaceutics12070642DOI Listing

Pulmonary Toxicity and Inflammatory Response of E-Cigarette Vape Cartridges Containing Medium-Chain Triglycerides Oil and Vitamin E Acetate: Implications in the Pathogenesis of EVALI.

Toxics 2020 Jun 28;8(3). Epub 2020 Jun 28.

Department of Environmental Medicine, School of Medicine & Dentistry, University of Rochester Medical Center, Rochester, NY 14642, USA.

Recently, there has been an outbreak associated with the use of e-cigarette or vaping products, associated lung injury (EVALI). The primary components of vaping products, vitamin E acetate (VEA) and medium-chain triglycerides (MCT), may be responsible for acute lung toxicity. Currently, little information is available on the physiological and biological effects of exposure to these products. Read More

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http://dx.doi.org/10.3390/toxics8030046DOI Listing

Design, optimization and evaluation of co-surfactant free microemulsion-based hydrogel with low surfactant for enhanced transdermal delivery of lidocaine.

Int J Pharm 2020 Jun 27;586:119415. Epub 2020 Jun 27.

School of Pharmacy, Shanxi Medical University, Taiyuan 030000, China. Electronic address:

Microemulsion is the preferred vehicle for local anesthetics; however, the toxicity and irritation associated with a quantity use of surfactants (S) and co-surfactants (CS), i.e., medium- or short-chain alcohols, restrict its commercial application. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2020.119415DOI Listing

Protective effect of punicalagin, the main polyphenol compound of pomegranate, against acrylamide-induced neurotoxicity and hepatotoxicity in rats.

Phytother Res 2020 Jun 27. Epub 2020 Jun 27.

Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Acrylamide (ACR) is widely used in industries. Oxidative stress and apoptosis pathways are important mechanisms behind ACR-induced hepatotoxicity and neurotoxicity. Regarding to antioxidant and antiapoptotic properties of punicalagin (PUN), the protective effect of this agent on ACR-induced toxicity in rat was evaluated. Read More

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http://dx.doi.org/10.1002/ptr.6774DOI Listing

Pulmonary toxicity and inflammatory response of e-cigarettes containing medium-chain triglyceride oil and vitamin E acetate: Implications in the pathogenesis of EVALI but independent of SARS-COV-2 COVID-19 related proteins.

bioRxiv 2020 Jun 15. Epub 2020 Jun 15.

Recently, there has been an outbreak associated with the use of e-cigarette or vaping products, associated lung injury (EVALI). The primary components of vaping products, vitamin E acetate (VEA) and medium-chain triglycerides (MCT) may be responsible for acute lung toxicity. Currently, little information is available on the physiological and biological effects of exposure to these products. Read More

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http://dx.doi.org/10.1101/2020.06.14.151381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310615PMC

The pharmaco-toxicological conundrum of oleander: Potential role of gut microbiome.

Authors:
Priyankar Dey

Biomed Pharmacother 2020 Jun 18;129:110422. Epub 2020 Jun 18.

Department of Biotechnology, Thapar Institute of Engineering and Technology, Patiala, Punjab, India. Electronic address:

Nerium oleander L., commonly known as oleander, is a toxic shrub and also a medicinal plant. All parts of oleander are rich in cardiac glycosides that inhibits Na/K-ATPase and induce inotropic effect on the cardiomyocytes. Read More

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http://dx.doi.org/10.1016/j.biopha.2020.110422DOI Listing

Effects of Selenium and Vitamin E on Enzymatic, Biochemical, and Immunological Biomarkers in Galleria mellonella L.

Sci Rep 2020 Jun 19;10(1):9953. Epub 2020 Jun 19.

Department of Biology, Faculty of Science-Literature, Adıyaman University, Adiyaman, Turkey.

To understand the effects of micronutrients have particular biological functions that are involved mainly in the antioxidant system, which has essential implications for the development of diseases, this study investigated how vitamin E, selenium, and their combination affect lipid, protein, carbohydrate, and malondialdehyde (MDA) content; antioxidant enzyme (catalase [CAT], superoxide dismutase [SOD], glutathione-S-transferase [GST]) activity; and the total hemocyte count (THC) in larvae of Galleria mellonella L. fed different diets. Diet 1 (100 µg of selenium) significantly decreased carbohydrate and lipid content. Read More

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http://dx.doi.org/10.1038/s41598-020-67072-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305100PMC

Smouldering ashes: burning questions after the outbreak of electronic cigarette or vaping-associated lung injury (EVALI).

Postgrad Med J 2020 Jun 18. Epub 2020 Jun 18.

Urgent Care, Cayman Islands Urgent Care, George Town, Cayman Islands.

In the summer of 2019, the Center for Disease Control and Prevention (CDC) declared an emergency of electronic cigarettes and/or vaping (vaping)-associated lung injury (EVALI) in the USA. The outbreak abated by January 2020, which the CDC attributed to heightened public awareness, 'user actions to reduce risk' and potentially the removal of vitamin E acetate (VEA) from vaping products (VEA is an oily chemical cutting agent, strongly associated with the disease). Even though the EVALI outbreak appears to be over, numerous epidemiological and medical questions are left still open. Read More

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http://dx.doi.org/10.1136/postgradmedj-2020-137673DOI Listing

Spontaneous Axonal Dystrophy in the Brain and Spinal Cord in Naïve Beagle Dogs.

Toxicol Pathol 2020 Jul 1;48(5):694-701. Epub 2020 Jun 1.

Global Pathology and Investigative Toxicology, Pfizer Inc, Groton, CT, USA.

Axonal dystrophy (AD) is a common age-related neurohistological finding in vertebrates that can be congenital or induced by xenobiotics, vitamin E deficiency, or trauma/compression. To understand the incidence and location of AD as a background finding in Beagle dogs used in routine toxicity studies, we examined central nervous system (CNS) and selected peripheral nervous system (PNS) tissues in twenty 18- to 24-month-old and ten 4- to 5-year-old control males and females. Both sexes were equally affected. Read More

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http://dx.doi.org/10.1177/0192623320926475DOI Listing

Nanoparticle delivery of a pH-sensitive prodrug of doxorubicin and a mitochondrial targeting VES-HR synergistically kill multi-drug resistant breast cancer cells.

Sci Rep 2020 May 26;10(1):8726. Epub 2020 May 26.

Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, ON, M5S 3E5, Canada.

Multi-drug resistance (MDR) remains a major obstacle in cancer treatment while being heavily dependent on mitochondrial activity and drug efflux. We previously demonstrated that cationic lipids, such as the vitamin E succinate modified octahistidine-octaarginine (VES-HR) conjugate, target mitochondria, resulting in depolarized mitochondria and inhibited drug efflux in MDR breast cancer cells. We hypothesized that the effective cell uptake, efflux inhibition, and mitochondrial depolarization properties of VES-HR would synergistically enhance the toxicity of a pH-sensitive prodrug of doxorubicin (pDox) when co-encapsulated in nanoparticles (NPs). Read More

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http://dx.doi.org/10.1038/s41598-020-65450-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251113PMC

Self-assembling prodrug nanotherapeutics for synergistic tumor targeted drug delivery.

Acta Biomater 2020 Jul 23;111:20-28. Epub 2020 May 23.

Skaggs Pharmaceutical Sciences Center, Department of Pharmacology & Toxicology, College of Pharmacy, The University of Arizona, Tucson, AZ, 85721, United States; NCI-designated University of Arizona Comprehensive Cancer Center, Tucson, Arizona, 85721, United States; Southwest Environmental Health Sciences Center, The University of Arizona, Tucson, 85721, United States; BIO5 Institute, The University of Arizona, Tucson, Arizona, 85721, United States. Electronic address:

Self-assembling prodrugs represents a robust and effective nanotherapeutic approach for delivering poorly soluble anticancer drugs. With numerous intrinsic advantages, self-assembling prodrugs possess the maximum drug loading capacity, controlled drug release kinetics, prolonged blood circulation, and preferential tumor accumulation based on the enhanced permeability and retention (EPR) effect. These prodrug conjugates allow for efficient self-assembly into nanodrugs with the potential of encapsulating other therapeutic agents that have different molecular targets, enabling simultaneous temporal-spatial release of drugs for synergistic antitumor efficacy with reduced systemic side effects. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.05.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245299PMC
July 2020
6.025 Impact Factor

Iron chaperone PCBP1 protects murine liver from lipid peroxidation and steatosis.

Hepatology 2020 May 21. Epub 2020 May 21.

Genetics and Metabolism Section, NIDDK, NIH, Bethesda, MD, USA.

Iron is essential yet also highly chemically reactive and potentially toxic. The mechanisms that allow cells to use iron safely are not clear; defects in iron management are a causative factor in the cell death pathway known as ferroptosis. Poly rC binding protein 1 (PCBP1) is a multifunctional protein that serves as a cytosolic iron chaperone, binding and transferring iron to recipient proteins in mammalian cells. Read More

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http://dx.doi.org/10.1002/hep.31328DOI Listing

Dual Receptor-Targeted and Redox-Sensitive Polymeric Micelles Self-Assembled from a Folic Acid-Hyaluronic Acid-SS-Vitamin E Succinate Polymer for Precise Cancer Therapy.

Int J Nanomedicine 2020 24;15:2885-2902. Epub 2020 Apr 24.

School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.

Purpose: Poor site-specific delivery and insufficient intracellular drug release in tumors are inherent disadvantages to successful chemotherapy. In this study, an extraordinary polymeric micelle nanoplatform was designed for the efficient delivery of paclitaxel (PTX) by combining dual receptor-mediated active targeting and stimuli response to intracellular reduction potential.

Methods: The dual-targeted redox-sensitive polymer, folic acid-hyaluronic acid-SS-vitamin E succinate (FHSV), was synthesized via an amidation reaction and characterized by H-NMR. Read More

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http://dx.doi.org/10.2147/IJN.S249205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188338PMC

Potential Protective Effects of Naringin on Oculo-Pulmonary Injury Induced by PM (Wood Smoke) Exposure by Modulation of Oxidative Damage and Acetylcholine Esterase Activity in a Rat Model.

Curr Ther Res Clin Exp 2020 20;92:100586. Epub 2020 Apr 20.

Toxicology and Safety Unit, Department of Environmental Health Sciences, Faculty of Public Health, College of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.

Background: Millions of households in the world depend on wood and biomass for cooking and heating. This dependence leads to undesirable toxic effects, such as ocular and pulmonary toxicity.

Objectives: The present study examined the potential oculoprotective and pulmonary protective activity of naringin (NRG), a naturally occurring flavonoid, against wood smoke (WS)-induced toxicity in a rat model. Read More

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http://dx.doi.org/10.1016/j.curtheres.2020.100586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214769PMC

Plasma metabolite biomarkers predictive of radiation induced cardiotoxicity.

Radiother Oncol 2020 Apr 20. Epub 2020 Apr 20.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington D.C., United States; Department of Biochemistry, Molecular and Cellular Biology, Georgetown University, Georgetown University Medical Center, Washington D.C., United States. Electronic address:

Purpose: Although advancements in cancer treatments using radiation therapy (RT) have led to improved outcomes, radiation-induced heart disease (RIHD) remains a significant source of morbidity and mortality in survivors of cancers in the chest. Currently, there are no diagnostic tests in clinical use due to a lack of understanding of the natural history and mechanisms of RIHD development. Few studies have examined the utility of using metabolomics to prospectively identify cancer survivors who are at risk of developing cardiotoxicity. Read More

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http://dx.doi.org/10.1016/j.radonc.2020.04.018DOI Listing

E-Cigarettes, Vaping Devices, and Acute Lung Injury.

Respir Care 2020 May;65(5):713-718

Division of Pulmonary and Critical Care, Department of Medicine, Georgetown University School of Medicine, Washington, District of Columbia.

"E-cigarettes" are a class of consumer devices designed to deliver drugs, primarily nicotine or marijuana oils, to the lung by vaporization. Regulation of the devices in the United States is relatively minimal, and research on both epidemiology and potential toxicity has focused on nicotine devices. In 2019, an outbreak of an acute respiratory illness in the United States was traced back to the contamination of e-cigarette fluids with vitamin E acetate, which had been used to disguise the dilution of marijuana oils. Read More

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http://dx.doi.org/10.4187/respcare.07733DOI Listing

Assessing the impact of arsenic metabolism efficiency on DNA methylation using Mendelian randomization.

Environ Epidemiol 2020 Apr 9;4(2):e083. Epub 2020 Apr 9.

Department of Public Health Sciences, The University of Chicago, Chicago, Illinois.

Background: Arsenic exposure affects >100 million people globally and increases risk for chronic diseases. One possible toxicity mechanism is epigenetic modification. Previous epigenome-wide association studies (EWAS) have identified associations between arsenic exposure and CpG-specific DNA methylation. Read More

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http://dx.doi.org/10.1097/EE9.0000000000000083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147391PMC

Ameliorative effect of edible Halopteris scoparia against cadmium-induced reproductive toxicity in male mice: A biochemical and histopathologic study.

Andrologia 2020 Jul 22;52(6):e13591. Epub 2020 Apr 22.

Department of Gynecologic and Obstetric Nursing, Faculty of Nursing, Ege University, Izmir, Turkey.

Cadmium (Cd) is a toxic metal affecting the reproductive system. Halopteris scoparia (brown algae) is generally consumed as a salad in the Far East countries. This study was conducted to compare and determine the possible protective effects of H. Read More

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http://dx.doi.org/10.1111/and.13591DOI Listing

Review of Health Consequences of Electronic Cigarettes and the Outbreak of Electronic Cigarette, or Vaping, Product Use-Associated Lung Injury.

J Med Toxicol 2020 Jul 16;16(3):295-310. Epub 2020 Apr 16.

North Texas Poison Center, Parkland Health and Hospital System, Dallas, TX, USA.

Electronic cigarettes (e-cigarettes) are battery-operated devices to insufflate nicotine or other psychoactive e-liquid aerosols. Despite initial claims of e-cigarettes as a nicotine-cessation device, aggressive marketing of e-cigarettes has led to an explosion in adolescents' and young adults' use over the last few years. Coupled with a lack of adequate investigation and regulation of e-cigarettes, the USA is facing an outbreak of e-cigarette, or vaping, product use-associated lung injury (EVALI) starting in mid-2019. Read More

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http://dx.doi.org/10.1007/s13181-020-00772-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320089PMC

pH-sensitive small molecule nanodrug self-assembled from amphiphilic vitamin B6-E analogue conjugate for targeted synergistic cancer therapy.

Colloids Surf B Biointerfaces 2020 Jul 28;191:111000. Epub 2020 Mar 28.

Engineering Research Center for Biomedical Materials, Anhui Key Laboratory of Modern Biomanufacturing, School of Life Sciences, Anhui University, 111 Jiulong Road, Hefei, Anhui Province, 230601, PR China. Electronic address:

To promote the targeted cancer therapy, the pH-sensitive small molecule nanodrug self-assembled from amphiphilic vitamin B6-E analogue conjugate was successfully constructed. Herein, water-soluble vitamin B6 with pKa (5.6) was chemically conjugated to lipid-soluble vitamin E succinate (α-TOS), which showed selective cancer cell killing ability and this amphiphilic small molecule vitamin conjugate could self-assemble to be free nanoparticles (NPs) and doxorubicin-loaded NPs (α-TOS-B6-NPs-DOX). Read More

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http://dx.doi.org/10.1016/j.colsurfb.2020.111000DOI Listing

EVALI and the Pulmonary Toxicity of Electronic Cigarettes: A Review.

J Gen Intern Med 2020 Jul 3;35(7):2130-2135. Epub 2020 Apr 3.

Department of Pulmonary and Critical Care Medicine, NYU Winthrop Hospital, 222 Station Plaza North, Suite 400, Mineola, NY, 11501, USA.

Electronic cigarettes are a novel and emerging product increasingly used by the general public. However, despite their popularity, they remain poorly studied and with likely serious health risks. EVALI, or "electronic cigarette or vaping product use-associated lung injury," is a recently described entity at the forefront of current investigations. Read More

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http://dx.doi.org/10.1007/s11606-020-05813-2DOI Listing

Aqueous Extract of Exhibit Potential Anticancer Activity and can be Used as a Possible Cancer Therapeutic Agent: A Study Involving and Approach.

J Am Coll Nutr 2020 Mar 19:1-16. Epub 2020 Mar 19.

Laboratory of Molecular and Cell Biology, Department of Life Science and Bioinformatics, Assam University, Silchar, India.

New cases of cancers are increasing at an alarming rate globally. It has been hypothesized that modern cancer treatment is associated with lots of side effects and thus evoking the need to develop safer treatment measures. Thus, the present study was undertaken to evaluate the anti-carcinogenic potential of a highly nutricious plant " (MO) and . Read More

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http://dx.doi.org/10.1080/07315724.2020.1735572DOI Listing

Redox-responsive biocompatible nanocarriers based on novel heparosan polysaccharides for intracellular anticancer drug delivery.

Asian J Pharm Sci 2020 Jan 17;15(1):83-94. Epub 2018 Dec 17.

School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, China.

Heparosan is a natural precursor of heparin biosynthesis in mammals. It is stable in blood circulation but can be degraded in lysosomes, showing good biocompatibility and long circulation features. So heparosan can be designed as anticancer drug carriers to increase tumor selectivity and improve the therapeutic effect. Read More

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http://dx.doi.org/10.1016/j.ajps.2018.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066043PMC
January 2020

E-cigarette, or Vaping, Product Use-Associated Lung Injury Among Clusters of Patients Reporting Shared Product Use - Wisconsin, 2019.

MMWR Morb Mortal Wkly Rep 2020 Mar 6;69(9):236-240. Epub 2020 Mar 6.

On July 10, 2019, Wisconsin Department of Health Services (WDHS) was notified of five previously healthy adolescents with severe lung injuries who reported use of e-cigarette, or vaping, products before symptom onset. As of December 31, 2019, 105 confirmed or probable cases of e-cigarette, or vaping, product use-associated lung injury (EVALI)* had been reported to WDHS . Three social clusters (A, B, and C), comprising eight EVALI patients (cluster A = two patients, cluster B = three, and cluster C = three) were identified. Read More

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http://dx.doi.org/10.15585/mmwr.mm6909a4DOI Listing

Surface Functionalization of Pegylated Gold Nanoparticles with Antioxidants Suppresses Nanoparticle-Induced Oxidative Stress and Neurotoxicity.

Chem Res Toxicol 2020 May 13;33(5):1195-1205. Epub 2020 Mar 13.

State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China.

Because of their biocompatibility and biosafety, pegylated Au NPs (Au@PEG), as a nanodrug-carrier, have been widely applied in different biomedical applications, including imaging and drug delivery systems. Under such conditions, the biosafety of Au@PEG has attracted tremendous attention. However, only a small number of studies focused on the neurotoxicity of Au@PEG used as drug delivery carriers not to mention reducing the neurotoxicity of Au@PEG. Read More

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http://dx.doi.org/10.1021/acs.chemrestox.9b00368DOI Listing

GC/MS assisted phytochemical analysis of Ajuga parviflora leaves extract along with anti-hepatotoxic effect against anti-tubercular drug induced liver toxicity in rat.

Pak J Pharm Sci 2020 Jan;33(1(Supplementary)):325-331

Department of Pharmacology, Faculty of Pharmacy, Federal Urdu University of Arts, Science and Technology, Karachi, Pakistan.

Owing to its traditional applications, the current study focuses on Ajuga parviflora (A. parviflora) leaves extract for phytochemical and pharmacological analysis. The principle constituents were identified through gas chromatography (GC), and gas chromatography/mass spectroscopy (GC/MS), these includes phthalic acid, squalene, α-tocopherol, vitamin E, phytol, 2-methylenecholestan-3-ol, stigmasterol, cholest-22-ene-21-ol and 3,5-dehydro-6-methoxy. Read More

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January 2020

Tuning mPEG-PLA/vitamin E-TPGS-based mixed micelles for combined celecoxib/honokiol therapy for breast cancer.

Eur J Pharm Sci 2020 Apr 24;146:105277. Epub 2020 Feb 24.

Department of Pharmaceutical Engineering, School of Chemical Engineering, Wuhan University of Technology, Wuhan 430070, PR China. Electronic address:

This study aimed to develop, evaluate, and optimize the mPEG-PLA/vitamin E-TPGS mixed micelle drug delivery system to encapsulate celecoxib (CXB) and honokiol (HNK) for intravenous treatment of breast cancer. To this end, we formulated CXB-loaded mPEG-PLA/vitamin E-TPGS (PV-CXB) and HNK-loaded mPEG-PLA/vitamin E-TPGS (PV-HNK) mixed micelles and analyzed their characteristics. The 4T1 cell line was used for cytotoxicity determination and cellular uptake experiments, and for establishing a 4T1-bearing mouse model for histopathology, immunofluorescence, terminal deoxynucleotidyl transferase-mediated nick end labeling, and Western blot analysis. Read More

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http://dx.doi.org/10.1016/j.ejps.2020.105277DOI Listing

The Protective Roles of Vitamin E and α-Lipoic Acid Against Nephrotoxicity, Lipid Peroxidation, and Inflammatory Damage Induced by Gold Nanoparticles.

Int J Nanomedicine 2020 31;15:729-734. Epub 2020 Jan 31.

Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia.

Background: Recently, use of nanotechnology in biomedical applications such as drug delivery and diagnostic and therapeutic tools has increased greatly. This study evaluated gold nanoparticle (GNPs)-induced nephrotoxic effects in rats in vivo, and examined protective effects of alpha-lipoic acid (α-Lip) and Vitamin E (Vit E) against nephrotoxicity, lipid peroxidation, and inflammatory kidney damage induced by GNPs.

Materials And Methods: Twenty-four male Wistar-Kyoto rats (220-240 g, 12 weeks old) were dosed with 50 μL of 10 nm GNPs administered intraperitoneally with or without 200 mg/kg/day Vit E or 200 mg/kg/day α-Lip. Read More

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http://dx.doi.org/10.2147/IJN.S192740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999539PMC

The combined effect of Cr(III) and NaCl determines changes in metal uptake, nutrient content, and gene expression in quinoa (Chenopodium quinoa Willd.).

Ecotoxicol Environ Saf 2020 Apr 21;193:110345. Epub 2020 Feb 21.

Dipartimento di Science Biologiche, Geologiche e Ambientali, Università di Bologna, Bologna, Italy.

Many areas of the world are affected simultaneously by salinity and heavy metal pollution. Halophytes are considered as useful candidates in remediation of such soils due to their ability to withstand both osmotic stress and ion toxicity deriving from high salt concentrations. Quinoa (Chenopodium quinoa Willd) is a halophyte with a high resistance to abiotic stresses (drought, salinity, frost), but its capacity to cope with heavy metals has not yet been fully investigated. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110345DOI Listing

Therapeutic role of garlic and vitamins C and E against toxicity induced by lead on various organs.

Environ Sci Pollut Res Int 2020 Mar 8;27(9):8953-8964. Epub 2020 Feb 8.

Microbial Biotechnology and Medical Toxicology Laboratory, Department of Zoology, University of Azad Jammu and Kashmir, Muzaffarabad, Pakistan.

Due to industrial and urban sewage, the metal contaminations in aquatic and terrestrial environments are increasing day by day, especially in developing countries. Despite the study of several years, we are inert far away from an actual medication for prolonged toxicity of heavy metals such as mercury, lead, cadmium etc. Lead is one of the most common heavy metals that possess toxicological effects on numerous tissues of animals as well as humans. Read More

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http://dx.doi.org/10.1007/s11356-020-07654-2DOI Listing
March 2020
2.828 Impact Factor

Protective effects of metallothionein and vitamin E in the trunk kidney and blood of cadmium poisoned Ctenopharyngodon idellus.

Fish Physiol Biochem 2020 Jun 3;46(3):1053-1061. Epub 2020 Feb 3.

College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, 611130, Sichuan, China.

Cadmium (Cd), a substance with one of the most critical health hazard indices, can cause damage to both the blood and kidneys and accumulates in the body at last. The present work studied the toxicological effects of Cd and the therapeutic effects of metallothionein (MT) and vitamin E (VE) on the trunk kidney and blood of freshwater grass carp (Ctenopharyngodon idellus). Grass carp were divided into three groups: Cd + phosphate-buffered saline (PBS) group, Cd + VE group, and the Cd + MT group. Read More

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http://dx.doi.org/10.1007/s10695-020-00771-2DOI Listing

The inhibitor-evoked shortage of tocopherol and plastoquinol is compensated by other antioxidant mechanisms in Chlamydomonas reinhardtii exposed to toxic concentrations of cadmium and chromium ions.

Ecotoxicol Environ Saf 2020 Mar 31;191:110241. Epub 2020 Jan 31.

Department of Plant Physiology and Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387, Kraków, Poland.

One of the major mechanisms of heavy metal toxicity is the induction of oxidative stress. Redox-active heavy metals, like chromium, can induce it directly, whereas redox-inactive metals, like cadmium, play an indirect role in the generation of reactive oxygen species (ROS). Living organisms defend themselves against oxidative stress taking advantage of low-molecular-weight antioxidants and ROS-detoxifying enzymes. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110241DOI Listing

Protective Effects of Dietary Antioxidants against Vanadium-Induced Toxicity: A Review.

Authors:
Iwona Zwolak

Oxid Med Cell Longev 2020 7;2020:1490316. Epub 2020 Jan 7.

Laboratory of Oxidative Stress, Centre for Interdisciplinary Research, The John Paul II Catholic University of Lublin, Konstantynów 1 J, 20-708 Lublin, Poland.

Vanadium (V) in its inorganic forms is a toxic metal and a potent environmental and occupational pollutant and has been reported to induce toxic effects in animals and people. and data show that high levels of reactive oxygen species are often implicated in vanadium deleterious effects. Since many dietary (exogenous) antioxidants are known to upregulate the intrinsic antioxidant system and ameliorate oxidative stress-related disorders, this review evaluates their effectiveness in the treatment of vanadium-induced toxicity. Read More

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http://dx.doi.org/10.1155/2020/1490316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973198PMC

Pulmonary Toxicity and the Pathophysiology of Electronic Cigarette, or Vaping Product, Use Associated Lung Injury.

Front Pharmacol 2019 14;10:1619. Epub 2020 Jan 14.

Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, United States.

New emerging tobacco products, especially electronic cigarettes (E-Cig) or electronic nicotine delivery systems (ENDS), have gained a huge popularity, particularly in younger populations. The lack of sufficient evidence-based health effect studies has promoted widespread use/abuse with the assumption that E-Cig or ENDS and/or vaping products are safer and less toxic than conventional tobacco smoking. However, the recent escalation in acute lung injuries and their associated fatalities among ENDS or vaping product users has now brought attention to this silent epidemic investigation into the constituents of ENDS/vaping products and their toxic effects on pulmonary health. Read More

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http://dx.doi.org/10.3389/fphar.2019.01619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971159PMC
January 2020

Update: Characteristics of a Nationwide Outbreak of E-cigarette, or Vaping, Product Use-Associated Lung Injury - United States, August 2019-January 2020.

MMWR Morb Mortal Wkly Rep 2020 Jan 24;69(3):90-94. Epub 2020 Jan 24.

Since August 2019, CDC, the Food and Drug Administration (FDA), state and local health departments, and public health and clinical stakeholders have been investigating a nationwide outbreak of e-cigarette, or vaping, product use-associated lung injury (EVALI) (1). This report updates patient demographic characteristics, self-reported substance use, and hospitalization dates for EVALI patients reported to CDC by states, as well as the distribution of emergency department (ED) visits related to e-cigarette, or vaping, products analyzed through the National Syndromic Surveillance Program (NSSP). As of January 14, 2020, a total of 2,668 hospitalized EVALI cases had been reported to CDC. Read More

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http://dx.doi.org/10.15585/mmwr.mm6903e2DOI Listing
January 2020

Characteristics of Persons Who Report Using Only Nicotine-Containing Products Among Interviewed Patients with E-cigarette, or Vaping, Product Use-Associated Lung Injury - Illinois, August-December 2019.

MMWR Morb Mortal Wkly Rep 2020 Jan 24;69(3):84-89. Epub 2020 Jan 24.

In 2019, the United States experienced an outbreak of e-cigarette, or vaping, product use-associated lung injury (EVALI) (1). Most EVALI patients have reported using tetrahydrocannabinol (THC)-containing e-cigarette, or vaping, products obtained from informal sources (2,3), and vitamin E acetate in these products has been closely linked with EVALI (4,5). However, some EVALI patients report using only nicotine-containing products. Read More

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http://dx.doi.org/10.15585/mmwr.mm6903e1DOI Listing
January 2020

γ-Tocotrienol and α-Tocopherol Ether Acetate Enhance Docetaxel Activity in Drug-Resistant Prostate Cancer Cells.

Molecules 2020 Jan 18;25(2). Epub 2020 Jan 18.

Department of Nutrition, Dietetics, and Food Science, Brigham Young University, Provo, UT 84602, USA.

Prostate cancer is the second most commonly diagnosed cancer in men, and metastatic prostate cancer is currently incurable. Prostate cancer frequently becomes resistant to standard of care treatments, and the administration of chemotherapeutic drugs is often accompanied by toxic side effects. Combination therapy is one tool that can be used to combat therapeutic resistance and drug toxicity. Read More

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http://dx.doi.org/10.3390/molecules25020398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024271PMC
January 2020

Selective Intratumoral Drug Release and Simultaneous Inhibition of Oxidative Stress by a Highly Reductive Nanosystem and Its Application as an Anti-tumor Agent.

Theranostics 2020 1;10(3):1166-1180. Epub 2020 Jan 1.

College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, P. R. China.

Excessive oxidative stress is always associated with the serious side effects of chemotherapy. In the current study, we developed a vitamin E based strongly reductive nanosystem to increase the loading efficiency of docetaxel (DTX, DTX-VNS), reduce its side toxicity and enhance the antitumor effect. We used Förster Resonance Energy Transfer (FRET) to reveal the and fate of DTX-VNS over time. Read More

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http://dx.doi.org/10.7150/thno.38627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956823PMC
January 2020

The potential gonadoprotective effects of grape seed extract against the histopathological alterations elicited in an animal model of cadmium-induced testicular toxicity.

Folia Morphol (Warsz) 2020 Jan 13. Epub 2020 Jan 13.

Department of Anatomy, Benha Faculty of Medicine, Benha University, Benha, Egypt.

Background: Grape seed extract (GSE) is a powerful antioxidant containing high levels of bioflavonoids, vitamin C and vitamin E. The aim of the work is to study the possible protective and ameliorative effects of grape seed extract in an animal model of cadmium (Cd)-induced testicular toxicity in rats.

Materials And Methods: A thirty-day oral gavage study in adult male albino rats was performed using 32 animals, randomly divided into 4 equal groups; negative control, cadmium (5 mg/k/day), grape seed extract (100 mg/k/day), and cadmium + GSE. Read More

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http://dx.doi.org/10.5603/FM.a2020.0003DOI Listing
January 2020

Co-encapsulation of docetaxel and thymoquinone in mPEG-DSPE-vitamin E TPGS-lipid nanocapsules for breast cancer therapy: Formulation optimization and implications on cellular and in vivo toxicity.

Eur J Pharm Biopharm 2020 Mar 7;148:10-26. Epub 2020 Jan 7.

Nanomedicine Research Lab, School of Pharmaceutical Education & Research, Jamia Hamdard, 110062 New Delhi, India. Electronic address:

Rationally designed combination nano-therapy approaches have emerged as a promising strategy for resistant breast cancer treatment. This research reports the combination of Docetaxel (DTX) and Thymoquinone (THQ) co-encapsulated within long circulating sub-100 nm mPEG-DSPE-Vitamin E TPGS-Lipid nanocapsules (DxTq-LNCs). DxTq-LNCs with sufficient drug loading exhibited controlled drug release, enhanced protein binding resistance (confirming its long circulation in physiological environment and suitability for iv application) and retained the antioxidant effects of THQ. Read More

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http://dx.doi.org/10.1016/j.ejpb.2019.12.016DOI Listing
March 2020
3.383 Impact Factor

Protective effects of melatonin and vitamin E in acetamiprid-induced nephrotoxicity.

Environ Sci Pollut Res Int 2020 Mar 8;27(9):9202-9213. Epub 2020 Jan 8.

Department of Biostatistics, Medical Faculty, Inonu University, Malatya, Turkey.

Investigation of probable toxic effects of acetamiprid (ACMP) on kidney and comparative analysis of the probable protective effects of vitamin E and melatonin were conducted in the present study. The ethics committee approval was obtained from Inonu University Medical Faculty Ethics Committee. Fifty Balb-c mice were randomly assigned to control, corn oil, ethyl alcohol, ACMP, ACMP + melatonin, ACMP + vitamin E, and ACMP + melatonin + vitamin E groups. Read More

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http://dx.doi.org/10.1007/s11356-019-06754-yDOI Listing

Colibri® insecticide induces male reproductive toxicity: alleviating effects of (Anacardiaceae) in rats.

Basic Clin Androl 2019 20;29:16. Epub 2019 Dec 20.

1Animal Physiology and Phytopharmacology Laboratory, Faculty of Science, University of Dschang, PO Box: 67, Dschang, Cameroon.

Background: Imidacloprid, a neonicotinoid insecticide, has been associated to severe reproductive toxicity in mammals. Although some preventive measures have been reported, curative strategies are yet to be explored. The present study was designed to investigate the alleviating effects of on the reproductive toxicity of colibri®, a commercial formulation of imidacloprid, in adult male rats. Read More

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http://dx.doi.org/10.1186/s12610-019-0096-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924042PMC
December 2019

Oxidative stress, hematological and biochemical alterations induced by sub-acute exposure to fipronil (COACH) in albino mice and ameliorative effect of selenium plus vitamin E.

Environ Sci Pollut Res Int 2020 Mar 30;27(8):7886-7900. Epub 2019 Dec 30.

Department of Pesticides, Faculty of Agriculture, Menoufia University, Shebin Elkom, MNF, 32511, Egypt.

Fipronil (FIP) is a highly effective, broad-use insecticide that belongs to the phenylpyrazole chemical group. It is extensively used in the agriculture and veterinary medicine for controlling a wide variety of pests. Though FIP showed lower toxicity in vertebrates than in insects, it was recognized to have a variety of toxic effects in mammals. Read More

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http://dx.doi.org/10.1007/s11356-019-06579-9DOI Listing

Alpha-tocopheryl succinate improves encapsulation, pH-sensitivity, antitumor activity and reduces toxicity of doxorubicin-loaded liposomes.

Eur J Pharm Sci 2020 Mar 24;144:105205. Epub 2019 Dec 24.

Department of Pharmaceutical Products, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil. Electronic address:

Doxorubicin (DOX) plays an important role in cancer treatment; however, high cardiotoxicity and low penetration in solid tumors are the main limitations of its use. Liposomal formulations have been developed to attenuate the DOX toxicity, but the technological enhancement of the liposomal formulation as well as the addition of another agent with antitumor properties, like alpha-tocopheryl succinate (TS), a semi-synthetic analog of vitamin E, could certainly bring benefits. Thus, in this study, it was proposed the development of liposomes composed of DOX and TS (pHSL-TS-DOX). Read More

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http://dx.doi.org/10.1016/j.ejps.2019.105205DOI Listing

Bendiocarb-induced nephrotoxicity in rats and the protective role of vitamins C and E.

Environ Sci Pollut Res Int 2020 Feb 23;27(6):6449-6458. Epub 2019 Dec 23.

Faculty of Science, Department of Biology, Gazi University, 06500, Teknikokullar, Ankara, Turkey.

Bendiocarb is a pesticide carbamate which is used to protect agricultural products and animals. In this study, rats were given orally with bendiocarb and also other chemicals via gavage. Male rats were randomly divided into eight groups (n = 6): group 1 served as controls; group 2 received vitamin C (100 mg/kg bw); group 3 received vitamin E (100 mg/kg bw); group 4 received vitamins C plus E; group 5 received bendiocarb (0. Read More

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http://dx.doi.org/10.1007/s11356-019-07260-xDOI Listing
February 2020

Acute Methylmercury Exposure and the Hypoxia-Inducible Signaling Pathway under Normoxic Conditions in the Rat Brain and Astrocytes .

Environ Health Perspect 2019 12 18;127(12):127006. Epub 2019 Dec 18.

Department of Preventive Medicine and Public Health Laboratory Sciences, School of Medicine, Jiangsu University, Zhenjiang, China.

Background: As a ubiquitous environmental pollutant, methylmercury (MeHg) induces toxic effects in the nervous system, one of its main targets. However, the exact mechanisms of its neurotoxicity have not been fully elucidated. Hypoxia-inducible (), a transcription factor, plays a crucial role in adaptive and cytoprotective responses in cells and is involved in cell survival, proliferation, apoptosis, inflammation, angiogenesis, glucose metabolism, erythropoiesis, and other physiological activities. Read More

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http://dx.doi.org/10.1289/EHP5139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957278PMC
December 2019

Nutritional neuropathies.

Muscle Nerve 2020 Jul 26;62(1):13-29. Epub 2019 Dec 26.

University of Virginia, Charlottesville, Virginia.

Neuropathies associated with nutritional deficiencies are routinely encountered by the practicing neurologist. Although these neuropathies assume different patterns, most are length-dependent, sensory axonopathies. Cobalamin deficiency neuropathy is the exception, often presenting with a non-length-dependent sensory neuropathy. Read More

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http://dx.doi.org/10.1002/mus.26783DOI Listing

Mancozeb exposure during development and lactation periods results in decreased oocyte maturation, fertilization rates, and implantation in the first-generation mice pups: Protective effect of vitamins E and C.

Toxicol Ind Health 2019 Nov-Dec;35(11-12):714-725

Department of Anatomical Sciences, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

This study aimed to evaluate the mancozeb (MNZ) impact on oocyte maturation of first-generation mice pups as well as their fertilization rate, embryo development, and implantation along with the preventative effect of vitamins E and C. Pregnant mice were randomly divided into six groups: control, vehicle, and MNZ (500 mg/kg body weight (BW)), vitamin E (200 mg/kg BW), MNZ plus vitamin E, MNZ plus vitamin C (100 mg/kg BW), and MNZ plus two vitamins. All treatments were conducted by oral gavage every 2 days from the second day of gestation until the end of lactation. Read More

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http://dx.doi.org/10.1177/0748233719890965DOI Listing

Formulation, Characterization And Evaluation Of Curcumin- Loaded PLGA- TPGS Nanoparticles For Liver Cancer Treatment.

Drug Des Devel Ther 2019 16;13:3569-3578. Epub 2019 Oct 16.

Department of Oncology, Beibei District Hospital of Traditional Chinese Medicine, Chongqing, People's Republic of China.

Background: Liver cancer is a major health problem facing mankind. Currently, the focus of research is to improve the treatment of liver cancer using a variety of treatment options such as providing chemotherapy drugs through nanocarriers.

Purpose: The aim of this study was to prepare a curcumin-loaded (PLGA/TPGS) NPs delivery system by the emulsification-solvent evaporation method in order to achieve synergistic antitumor activity against liver cancer. Read More

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http://dx.doi.org/10.2147/DDDT.S211748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801559PMC