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    3597 results match your criteria Vitamin E Toxicity

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    Effects of copper on viability and functional properties of hippocampal neurons in vitro.
    Exp Toxicol Pathol 2017 Feb 8. Epub 2017 Feb 8.
    Research Center of Neurology, Moscow, Russia; Moscow State University, A.N. Belozersky Institute of Physico-Chemical Biology, Biological Faculty, Moscow, Russia. Electronic address:
    Copper (Cu(2+)) is an essential metal presented in the mammalian brain and released from synaptic vesicles following neuronal depolarization. However, the disturbance of Cu(2+) homeostasis results in neurotoxicity. In our study we performed for the first time a combined functional investigation of cultured hippocampal neurons under Cu(2+) exposure, its effect on spontaneous spike activity of hippocampal neuronal network cultured on multielectrode array (MEA), and development of long-term potentiation (LTP) in acute hippocampal slices in the presence of Cu(2+). Read More

    p66shc-mediated toxicity of high-dose α-tocopherol in renal proximal tubule cells.
    J Physiol Biochem 2017 Feb 2. Epub 2017 Feb 2.
    Department of Pediatrics, Division of Pediatric Nephrology, University of Mississippi Medical Center, 2500 N State St, Jackson, MS, 39216, USA.
    α-Tocopherol (TOC) is a widely used supplement known for its role as an antioxidant. Previously, we have shown that TOC elicits adaptive responses by upregulating the ERK/CREB/HO-1 pathway, which depends on its concentration in cultured renal proximal tubule cells (RPTCs). This suggests that high-dose TOC (hTOC) may elicit adverse effects via inflicting oxidative stress. Read More

    Antioxidant effect of vitamin E and 5-aminosalicylic acid on acrylamide induced kidney injury in rats.
    Saudi Med J 2017 Feb;38(2):132-137
    Department of Anatomy, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia. E-mail.
    Objectives: To explore renal toxicity caused by sub-acute exposure of acrylamide and to study the protective effect of 5-Aminosalicylic acid (5-ASA) and Vitamin E (vit-E)on Acrylamide (ACR) induced renal toxicity. Methods: This study was conducted at King Fahad Medical Research Centre, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia, between August and November 2015. A total of 49 adult Wistar rats (250 ± 20g) aged 60 days were kept in a controlled environment and used in the present study. Read More

    Synthesis, characterization, and in-vitro antitumor activity of the polyethylene glycol (350 and 1000) succinate derivatives of the tocopherol and tocotrienol isomers of Vitamin E.
    Int J Pharm 2017 Jan 16;519(1-2):145-156. Epub 2017 Jan 16.
    College of Health and Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA, USA; College of Pharmacy, Taipei Medical University, Taipei, Taiwan. Electronic address:
    Vitamin E refers to a group of saturated tocopherol (T) isomers and the biologically more active unsaturated tocotrienol (T3) isomers. PEGylated α-tocopherol, commercially known as Vitamin E TPGS, has been used as an emulsifier and therapeutic agent for children with vitamin E deficiency. Limited information, however, is available about the PEG conjugates of the tocotrienol isomers of vitamin E. Read More

    Vitamin E reduces endosulfan-induced toxic effects on morphology and behavior in early development of zebrafish (Danio rerio).
    Food Chem Toxicol 2017 Mar 6;101:84-93. Epub 2017 Jan 6.
    National Institute of Nutrition and Seafood Research (NIFES), PO Box 2029, NO-5817 Bergen, Norway. Electronic address:
    The aim of this study was to investigate if vitamin E (α-TOC) modulates the developmental toxicity of the pesticide endosulfan (ESF), using a modified zebrafish embryotoxicity test (ZET). Zebrafish (Danio rerio) embryos were exposed from 6 to 72 h post fertilization (hpf) to either ESF (0.1-50 mg/L) or α-TOC (0. Read More

    CYP4F2 repression and a modified alpha-tocopherol (vitamin E) metabolism are two independent consequences of ethanol toxicity in human hepatocytes.
    Toxicol In Vitro 2017 Jan 3;40:124-133. Epub 2017 Jan 3.
    Department of Pharmaceutical Sciences, University of Perugia, Italy.
    The expression of CYP4F2, a form of cytochrome P-450 with proposed role in α-tocopherol and long-chain fatty acid metabolism, was explored in HepG2 and HepaRG human hepatocytes during ethanol toxicity. Cytotoxicity, ROS production, and JNK and ERK1/2 kinase signaling increased in a dose and time-dependent manner during ethanol treatments; CYP4F2 gene expression decreased, while other CYP4F forms, namely 4F11 and 12, increased along with 3A4 and 2E1 isoforms. α-Tocopherol antagonized the cytotoxicity and CYP4F2 gene repression effect of ethanol in HepG2 cells. Read More

    Bendiocarb induced histopathological and biochemical alterations in rat liver and preventive role of vitamins C and E.
    Environ Toxicol Pharmacol 2017 Jan 27;49:148-155. Epub 2016 Nov 27.
    Gazi University, Faculty of Science, Department of Biology, 06500, Ankara, Turkey.
    In this study, biochemical changes and histological structure of rat liver after bendiocarb administration and possible preventive effects of vitamins C and E were studied. The animals were given with bendiocarb, vitamin C and vitamin E, daily 0,8mg/kg of body weight (bw), 100mg/kg-bw and 100mg/kg-bw for 28days, respectively. Lipid peroxidation, antioxidant enzyme activities, histological alterations and antioxidant capacity assays of liver and also liver function tests and lipid profile were measured. Read More

    Different doses of dexmedetomidine reduce plasma cytokine production, brain oxidative injury, PARP and caspase expression levels but increase liver oxidative toxicity in cerebral ischemia-induced rats.
    Brain Res Bull 2016 Dec 19;130:1-9. Epub 2016 Dec 19.
    Unit of Anesthesiology and Reanimation, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Suleyman Demirel University, Isparta, Turkey.
    Cerebral ischemia-induced progression of brain, liver, and erythrocyte oxidative injuries might be modulated by dexmedetomidine (DEX) as a potent antioxidant and anti-inflammatory drug. The present study was conducted to explore whether two different doses of DEX protect against plasma cytokine and brain, liver and erythrocyte oxidative toxicity and apoptosis in cerebral ischemia-induced rats. Forty-two rats were equally divided into 7 groups. Read More

    Tumor regression after intravenous administration of targeted vesicles entrapping the vitamin E α-tocotrienol.
    J Control Release 2017 Jan 18;246:79-87. Epub 2016 Dec 18.
    Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, United Kingdom. Electronic address:
    The therapeutic potential of tocotrienol, a member of the vitamin E family of compounds with potent in vitro anti-cancer properties, is limited by its inability to specifically reach tumors following intravenous administration. The purpose of this study is to determine whether a novel tumor-targeted vesicular formulation of tocotrienol would suppress the growth of A431 epidermoid carcinoma and B16-F10 melanoma in vitro and in vivo. In this work, we demonstrated that novel transferrin-bearing multilamellar vesicles entrapping α-T3 resulted in a dramatically improved (by at least 52-fold) therapeutic efficacy in vitro on A431 cell line, compared to the free drug. Read More

    Protective effects of levamisole, acetylsalicylic acid, and α-tocopherol against dioxin toxicity measured as the expression of AhR and COX-2 in a chicken embryo model.
    Histochem Cell Biol 2016 Dec 10. Epub 2016 Dec 10.
    Laboratory of Neurotoxicology and Environmental Diagnostics, Wroclaw Medical University, Bartla 5, 51-618, Wrocław, Poland.
    Polychlorinated dibenzo-p-dioxins and dibenzofurans (dioxins) are classed as persistent organic pollutants and have adverse effects on multiple functions within the body. Dioxins are known carcinogens, immunotoxins, and teratogens. Dioxins are transformed in vivo, and interactions between the products and the aryl hydrocarbon receptor (AhR) lead to the formation of proinflammatory and toxic metabolites. Read More

    Effectiveness and safety of nutritional supplements in the treatment of hereditary retinal dystrophies: a systematic review.
    Eye (Lond) 2017 Feb 9;31(2):273-285. Epub 2016 Dec 9.
    Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC), Madrid, Spain.
    The hereditary retinal dystrophies (HRDs) are a group of genetically determined disorders that result in loss of the visual function. There is a lack of standard pharmacological treatments or widely accepted nutritional recommendations. The objective of this review is to summarise the scientific evidence on the effectiveness and safety of nutritional supplements for the treatment of HRDs. Read More

    Combined effects of cadmium, temperature and hypoxia-reoxygenation on mitochondrial function in rainbow trout (Oncorhynchus mykiss).
    Aquat Toxicol 2017 Jan 18;182:129-141. Epub 2016 Nov 18.
    Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE C1A 4P3, Canada. Electronic address:
    Although aquatic organisms face multiple environmental stressors that may interact to alter adverse outcomes, our knowledge of stressor-stressor interaction on cellular function is limited. We investigated the combined effects of cadmium (Cd), hypoxia-reoxygenation (H-R) and temperature on mitochondrial function. Liver mitochondria from juvenile rainbow trout were exposed to Cd (0-20μM) and H-R (0 and 5min) at 5, 13 and 25°C followed by measurements of mitochondrial Cd load, volume, complex І active (A)↔deactive (D) transition, membrane potential, ROS release and ultrastructural changes. Read More

    The Vitamin E Analog Gamma-Tocotrienol (GT3) and Statins Synergistically Up-Regulate Endothelial Thrombomodulin (TM).
    Int J Mol Sci 2016 Nov 18;17(11). Epub 2016 Nov 18.
    Division of Radiation Health, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
    Statins; a class of routinely prescribed cholesterol-lowering drugs; inhibit 3-hydroxy-3-methylglutaryl-coenzymeA reductase (HMGCR) and strongly induce endothelial thrombomodulin (TM); which is known to have anti-inflammatory; anti-coagulation; anti-oxidant; and radioprotective properties. However; high-dose toxicity limits the clinical use of statins. The vitamin E family member gamma-tocotrienol (GT3) also suppresses HMGCR activity and induces TM expression without causing significant adverse side effects; even at high concentrations. Read More

    The effect of dual-functional hyaluronic acid-vitamin E succinate micelles on targeting delivery of doxorubicin.
    Int J Nanomedicine 2016;11:5851-5870. Epub 2016 Nov 7.
    Modern Research Center for Traditional Chinese Medicine.
    Tumor-targeted delivery system has been developed as an attractive strategy for effective tumor therapy. In this study, in order to enhance the antitumor effects of doxorubicin (DOX), amphiphilic hyaluronic acid (HA)-conjugated vitamin E succinate (VES) copolymers (HA-VES) with different degrees of substitution (DS) were prepared with synergistic antitumor effects and active targeting activities, and utilized as nanocarriers for the efficient delivery of DOX. DOX-loaded HA-VES polymeric micelles (HA-VES/DOX) self-assembled from dual-functional HA-VES copolymer and exhibited excellent loading efficiency and superior colloidal stability. Read More

    In vitro toxicity of pirimiphos-methyl in Atlantic salmon hepatocytes.
    Toxicol In Vitro 2017 Mar 12;39:1-14. Epub 2016 Nov 12.
    National Institute of Nutrition and Seafood Research, Bergen, Norway.
    Recent screening of Atlantic salmon feeds has uncovered residues of several pesticides, including pirimiphos-methyl. Pirimiphos-methyl is an organophosphate (OP) insecticide, causing inhibition of acetylcholinesterase in target organisms. The aim of this study was to examine pirimiphos-methyl non-targeted mode of action toxicity in Atlantic salmon using in vitro exposure. Read More

    Antioxidant and anti-inflammatory effects of Nasturtium officinale involved in attenuation of gentamicin-induced nephrotoxicity.
    Toxicol Mech Methods 2016 Nov 23:1-8. Epub 2016 Nov 23.
    b Department of Toxicology and Pharmacology, Faculty of Pharmacy , Mazandaran University of Medical Sciences , Sari , Iran.
    Background And Purpose: Gentamicin (GM) is used against bacterial infections. The aim of our investigation was to evaluate the role of inflammation and also oxidative damage in nephrotoxic potential of GM and protective effects of Nasturtium officinale (watercress) against GM-induced nephrotoxicity in Wistar rats.

    Material And Methods: The animals were divided into eight groups: control, solvent, GM (80 mg/kg IP), GM with three doses (50, 100 and 200 mg/kg/d) of hydroalcoholic extract of watercress and one group only received high dose of extract and a group which received GM plus vitamin E for 10 consecutive days. Read More

    Ameliorative potential of α-tocopherol against flubendiamide and copper-induced testicular-insult in Wistar rats.
    Chem Biol Interact 2016 Dec 4;260:91-101. Epub 2016 Nov 4.
    Department of Veterinary Physiology, College of Veterinary Science and Animal Husbandry, U.P. Pt. Deen Dayal Upadhyay Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan (DUVASU), Mathura, 281001, India.
    Study was undertaken to evaluate ameliorative potential of α-tocopherol against copper sulphate and flubendiamide alone and in combination-induced toxicity in rats following 90 days exposure. Absolute and relative organ weights did not differ between treatments groups. Increase of LPO in copper and flubendiamide intoxicated rats but modest increase in copper + flubendiamide group. Read More

    Evaluation of Some Biochemical Parameters and Brain Oxidative Stress in Experimental Rats Exposed Chronically to Silver Nitrate and the Protective Role of Vitamin E and Selenium.
    Toxicol Res 2016 Oct 30;32(4):301-309. Epub 2016 Oct 30.
    Laboratory of Applied Biochemistry and Microbiology, Department of Biochemistry, Science faculty, Badji Mokhtar University, BP 12 Sidi Amar, Annaba, Algeria.
    Due to undesirable hazardous interactions with biological systems, this investigation was undertaken to evaluate the effect of chronic exposure to silver on certain biochemical and some oxidative stress parameters with histopathological examination of brain, as well as the possible protective role of selenium and/or vitamin E as nutritional supplements. Thirty six male rats were divided into six groups of six each: the first group used as a control group. Group II given both vitamin E (400 mg/kg) of diet and selenium (Se) (1 mg/L) in their drinking water. Read More

    Vitamin E: Emerging aspects and new directions.
    Free Radic Biol Med 2017 Jan 2;102:16-36. Epub 2016 Nov 2.
    Department of Biochemistry, Faculty of Medicine, Genetic and Metabolic Diseases Research Center (GEMHAM), Marmara University, 34854 Maltepe, Istanbul, Turkey. Electronic address:
    The discovery of vitamin E will have its 100th anniversary in 2022, but we still have more questions than answers regarding the biological functions and the essentiality of vitamin E for human health. Discovered as a factor essential for rat fertility and soon after characterized for its properties of fat-soluble antioxidant, vitamin E was identified to have signaling and gene regulation effects in the 1980s. In the same years the cytochrome P-450 dependent metabolism of vitamin E was characterized and a first series of studies on short-chain carboxyethyl metabolites in the 1990s paved the way to the hypothesis of a biological role for this metabolism alternative to vitamin E catabolism. Read More

    Melissa officinalis and vitamin E as the potential therapeutic candidates for reproductive toxicity caused by anti-cancer drug, cisplatin, in male rats.
    Recent Pat Anticancer Drug Discov 2016 10 26. Epub 2016 Oct 26.
    Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
    Background: High doses of Cisplatin (CP) can disrupt the normal function of various tissues such as ovaries and testis. In almost all the patients, spermiotoxicity of CP causes temporary or permanent azoospermia.

    Objective: In this study, the defensive effect of Melissa officinalis and vitamin E against testicular injuries caused by CP in male rats was evaluated. Read More

    One-Step Self-Assembling Nanomicelles for Pirarubicin Delivery To Overcome Multidrug Resistance in Breast Cancer.
    Mol Pharm 2016 Nov 21;13(11):3934-3944. Epub 2016 Oct 21.
    Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, Sichuan University , Chengdu 610041, China.
    Tumor cells can acquire multidrug resistance (MDR) as a result of drug efflux mediated by P-glycoprotein (P-gp). Here we report a targeted delivery system to carry pirarubicin (THP) to MDR breast cancer both in vitro and in vivo. PEG-derivatized vitamin E (PAMV6) amphiphiles loaded with THP were self-assembled in a single step. Read More

    Protective effects of vitamin E on sodium arsenite-induced toxicity, testicular measurements and histopathological studies of testes in Teddy goat bucks.
    Andrologia 2016 Sep 29. Epub 2016 Sep 29.
    Department of Theriogenology, University of Agriculture, Faisalabad, Pakistan.
    The objective of this study was to investigate the toxic effects of arsenic on testicular measurements and histology of adult Teddy goats bucks and to examine whether these toxic effects are scavenged by vitamin E. Twelve adult Teddy goat bucks were divided randomly into three groups, A, B and C. Group A was kept as control, the B was given sodium arsenite 5 mg/kg BW per day, and group C was fed with vitamin E 200 mg/kg BW per day + arsenic 5 mg/kg BW per day. Read More

    NMDA-Receptors Are Involved in Cu2+/Paraquat-Induced Death of Cultured Cerebellar Granule Neurons.
    Biochemistry (Mosc) 2016 Aug;81(8):899-905
    Neurology Research Center, Moscow, 125367, Russia.
    Rat cultured cerebellar granule neurons (CGNs) were not sensitive to CuCl2 (1-10 µM, 24 h), whereas paraquat (150 µM) decreased neuronal survival to 79 ± 3% of control level. Simultaneous treatment of CGNs with paraquat and CuCl2 (2, 5, or 10 µM Cu2+/paraquat) caused significant copper dose-dependent death, lowering their survival to 56 ± 4, 37 ± 3, or 16 ± 2%, respectively, and stimulating elevated production of free radicals in CGNs. Introduction of vitamin E, a non-competitive antagonist of NMDA subtype of glutamate receptors (MK-801), and also removal of glutamine from the incubation medium decreased toxicity of Cu2+/paraquat mixture. Read More

    Oxidative stress responses in Wistar rats on subacute exposure to pharmaceutical wastewater.
    Environ Sci Pollut Res Int 2016 Dec 19;23(23):24158-24165. Epub 2016 Sep 19.
    Faculty of Pharmacy, Government College University, Faisalabad, Pakistan.
    Water pollution has been a major concern for agrarian societies like Pakistan. Pharmaceutical industries are amongst the foremost contributor to industrial waste. Present study addresses the generation of oxidative stress caused by 2 months exposure to pharmaceutical wastewater in rats and their response to oral treatment with vitamin E, a potent antioxidant. Read More

    Vitamin E-Labeled Polyethylenimine for in vitro and in vivo Gene Delivery.
    Biomacromolecules 2016 Oct 7;17(10):3153-3161. Epub 2016 Sep 7.
    State Key Laboratory of Natural and Biomimetic Drugs, Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University , No. 38 Xueyuan Road Beijing, 100191, China.
    A series of Vitamin E (vitE)-labeled PEIs (PEI-vitEn) were synthesized and showed excellent complexation ability with plasmid DNA (pDNA). The cellular uptake of PEI-vitEn/pDNA complexes was greatly enhanced with the increase of vitE labeling, which is much better than that of control PEI25 in three different cell lines. PEI-vitE6 showed the best performance in gfp pDNA delivery and following GFP expression in HEK-293A cells. Read More

    Sensitive biomarker responses of the shrimp Palaemonetes argentinus exposed to chlorpyrifos at environmental concentrations: Roles of alpha-tocopherol and metallothioneins.
    Aquat Toxicol 2016 Oct 24;179:72-81. Epub 2016 Aug 24.
    Centro de Investigaciones en Bioquímica Clínica e Inmunología-CIBICI, Facultad de Ciencias Químicas, CONICET, UNC, Haya de la Torre esq., Medina Allende, 5000 Córdoba, Argentina. Electronic address:
    The aim of this study was to evaluate the toxic effects of chlorpyrifos (CPF) at environmental concentrations on the shrimp Palaemonetes argentinus, a South American native species. Organisms were exposed to environmentally relevant concentrations of CPF (from 3.5 to 94. Read More

    Antioxidant and anti-inflammatory role of zingerone in ethanol-induced hepatotoxicity.
    Mol Cell Biochem 2016 Oct 20;421(1-2):169-81. Epub 2016 Aug 20.
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, 608 002, Tamilnadu, India.
    Alcoholic liver disease is a direct result of alcohol-induced hepatotoxicity coupled with impaired hepatic regenerative activity. Our aim of the study was to investigate the beneficial effect of zingerone on hepatic oxidative stress and inflammation induced by ethanol in experimental rats. Male albino Wistar rats were divided into four groups. Read More

    Renoprotective Effect of Plantago Major Against Nephrotoxicity and Oxidative Stress Induced by Cisplatin.
    Iran J Kidney Dis 2016 Jul;10(4):182-8
    Neurogenic Inflammation Research Center and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
    Introduction: The aim of this study was to investigate the possible renoprotective effect of Plantago major extract against cisplatin-induced nephrotoxicity in rats.

    Materials And Methods: Rats were divided into 6 groups. The first group was the control, group 2 was treated with cisplatin (7 mg/kg, single dose), and groups 3 to 6 received cisplatin with vitamin E (100 mg/kg) and Plantago major  extract at doses of 300 mg/kg, 600 mg/kg, and 1200 mg/kg, for 20 days. Read More

    Vitamin E δ-tocotrienol triggers endoplasmic reticulum stress-mediated apoptosis in human melanoma cells.
    Sci Rep 2016 Jul 27;6:30502. Epub 2016 Jul 27.
    Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milano, 20133, Italy.
    Malignant melanoma is the leading cause of death from skin cancer. Drug toxicity and resistance represent a serious challange for melanoma treatments. Evidence demonstrates that natural compounds may play a crucial role in cancer prevention, growth and progression. Read More

    Tissue-Specific Effects of Vitamin E Supplementation.
    Int J Mol Sci 2016 Jul 19;17(7). Epub 2016 Jul 19.
    Biochemistry Department, Medical Academy, Lithuanian University of Health Sciences, Eiveniu 4, LT-50009 Kaunas, Lithuania.
    A multivitamin and mineral supplementation study of 6 weeks was conducted with male and female mice. The control group received a standard dose of vitamins and minerals of 1× the Recommended Daily Intake (RDI), whereas a second group received 3× RDI. A third group received a high dose of vitamin E (25× RDI), close to the upper limit of toxicity (UL), but still recommended and considered to be harmless and beneficial. Read More

    Protective effect of vitamin E on sperm motility and oxidative stress in valproic acid treated rats.
    Food Chem Toxicol 2016 Sep 14;95:159-67. Epub 2016 Jul 14.
    Department of Physiology and Pharmacology, Federal University of Santa Maria (UFSM), Santa Maria, RS, 97105-900, Brazil. Electronic address:
    Long-term administration of valproic acid (VPA) is known to promote reproductive impairment mediated by increase in testicular oxidative stress. Vitamin E (VitE) is a lipophilic antioxidant known to be essential for mammalian spermatogenesis. However, the capacity of this vitamin to abrogate the VPA-mediated oxidative stress has not yet been assessed. Read More

    Oxidative stress and antioxidant responses to increasing concentrations of trivalent chromium in the Andean crop species Chenopodium quinoa Willd.
    Ecotoxicol Environ Saf 2016 Nov 9;133:25-35. Epub 2016 Jul 9.
    Dipartimento BiGeA, Università di Bologna, via Irnerio 42, 40126 Bologna, Italy. Electronic address:
    Quinoa (Chenopodium quinoa Willd), an ancient Andean seed crop, exhibits exceptional nutritional properties and resistance to abiotic stress. The species' tolerance to heavy metals has, however, not yet been investigated nor its ability to take up and translocate chromium (Cr). This study aimed to investigate the metabolic adjustments occurring upon exposure of quinoa to several concentrations (0. Read More

    Prophylactic Effects of Garlic Oil and Onion Oil Fractions as Compared to Vitamin E on Rats Orally Fed with Lead Acetate Solution.
    Indian J Clin Biochem 2016 Jul 29;31(3):260-9. Epub 2016 Feb 29.
    Sree Gokulam Medical College, Venjaramoodu, Thiruvananthapuram, India.
    Heavy metal pollution is a global public health challenge due to its stable and persistent environmental contamination. Of these lead is considered to be one of the most common ubiquitous and industrial pollutants and at low concentration it exerts extensive damages to the tissues. Daily feeding of lead acetate solution (Dose: 10 mg/kg/day) to normal rats for a month adversely altered the parameters of blood, serum and tissues, viz; RBC, WBC, Hb, ɗ- ALAD (Delta amino levulinic acid dehydratase), Pb content, lipids, oxidized lipids (TBARS), vitamins C and E and GSH levels and activities of AST, ALT and antioxidant enzymes viz; catalase, GR, Gpx and SOD. Read More

    Protective effect of crocin against apoptosis induced by subchronic exposure of the rat vascular system to diazinon.
    Toxicol Ind Health 2016 Jul 20;32(7):1237-45. Epub 2014 Nov 20.
    Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Research has suggested that natural antioxidant, crocin, an active ingredient of saffron, may protect against diazinon (DZN)-induced toxicity. Although increased production of lipid peroxidation by DZN in rat aorta has been shown previously, the effects of DZN on oxidative stress-induced apoptosis in vascular system have not been evaluated. In this study, the effect of crocin on DZN-induced apoptosis in rat vascular system was investigated. Read More

    Protective Effects of Selenium, N-Acetylcysteine and Vitamin E Against Acute Ethanol Intoxication in Rats.
    Biol Trace Elem Res 2017 Jan 1;175(1):177-185. Epub 2016 Jun 1.
    Department of Dermatology, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey.
    The aim of this study was to determine possible protective influences of selenium (Se), N-acetylcysteine (NAC), and vitamin E (Vit E) against acute ethanol (EtOH) intoxication. Thirty-six rats were divided into six groups: I (control), II (EtOH), III (EtOH + Se), IV (EtOH + Vit E), V (EtOH + NAC), and VI (EtOH + mix). Except group I, EtOH was given the other pretreated (groups III, IV, V, and VI) and untreated groups (group II). Read More

    The protective effect of Nigella sativa against cisplatin-induced nephrotoxicity in rats.
    Avicenna J Phytomed 2016 Jan-Feb;6(1):44-54
    Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
    Objective: The clinical use of cisplatin is highly restricted, because of its nephrotoxicity. In this study the protective effect of Nigella sativa (N. sativa) against cisplatin-induced nephrotoxicity was investigated in rats. Read More

    Development and evaluation of vitamin E d-α-tocopheryl polyethylene glycol 1000 succinate-mixed polymeric phospholipid micelles of berberine as an anticancer nanopharmaceutical.
    Int J Nanomedicine 2016 26;11:1687-700. Epub 2016 Apr 26.
    Department of Pharmaceutical Sciences, College of Pharmacy-Glendale, Midwestern University, Glendale, AZ, USA; Nanomedicine Center of Excellence in Translational Nanomedicine, Midwestern University, Glendale, AZ, USA.
    Berberine (Brb) is an active alkaloid occurring in various common plant species, with well-recognized potential for cancer therapy. Brb not only augments the efficacy of antineoplastic chemotherapy and radiotherapy but also exhibits direct antimitotic and proapoptotic actions, along with distinct antiangiogenic and antimetastatic activities in a variety of tumors. Despite its low systemic toxicity, several pharmaceutical challenges limit the application of Brb in cancer therapy (ie, extremely low solubility and permeability, very poor pharmacokinetics (PKs), and oral bioavailability). Read More

    Matrix metalloproteinases-2/9-sensitive peptide-conjugated polymer micelles for site-specific release of drugs and enhancing tumor accumulation: preparation and in vitro and in vivo evaluation.
    Int J Nanomedicine 2016 22;11:1643-61. Epub 2016 Apr 22.
    Key Laboratory of Smart Drug Delivery, Ministry of Education and People's Liberation Army of China, School of Pharmacy, Fudan University, Shanghai, People's Republic of China.
    Since elevated expression of matrix metalloproteinase (MMP)-2 and MMP-9 is commonly observed in several malignant tumors, MMPs have been widely reported as key factors in the design of drug delivery systems. Several strategies have been proposed to develop MMPs-responsive nanoparticles to deliver chemotherapeutics to malignant solid tumors. A stimuli-responsive drug delivery system, which could be cleaved by MMPs, was proposed in this study. Read More

    Vitamins A and E content of commercial infant foods in the UK: A cause for concern?
    Food Chem 2016 Nov 11;210:56-62. Epub 2016 Apr 11.
    Faculty of Engineering and Science, University of Greenwich, Medway Campus, Chatham Maritime, Kent ME4 4TB, UK. Electronic address:
    According to the European Food Safety Authority, currently, there are no reliable data or robust guidelines available in relation to the micronutrient composition of infant foods. This study evaluated the intake of vitamins A and E of infants from 'ready-to-feed' foods and formulas. Normal phase high performance liquid chromatography was employed for simultaneous quantification of retinyl acetate, retinyl palmitate, α-tocopherol and γ-tocopherol, reverse phase high performance liquid chromatography for the quantification of β-carotene, and UV spectrophotometry for the quantification of carotenoids from selected infant food samples. Read More

    Naringin Ameliorates HIV-1 Nucleoside Reverse Transcriptase Inhibitors- Induced Mitochondrial Toxicity.
    Curr HIV Res 2016 ;14(6):506-516
    Department of Pharmacology, Discipline of Pharmaceutical Sciences, School of Health Sciences, University of KwaZulu-Natal, Westville campus, Durban 4001, South Africa.
    Background: Mitochondrial reactive oxygen species (ROS) generation and defective oxidative phosphorylation (OXPHOS) have been proposed as possible mechanisms underlying the development of nucleoside reverse transcriptase inhibitors (NRTIs)-induced mitochondrial toxicities. Available options in managing these complications have, so far, produced controversial results, thus necessitating further research into newer agents with promise. Antioxidant and free-radical scavenging effects of naringin, a plant-derived flavonoid, have previously been demonstrated. Read More

    Low-Chlorinated Non-Dioxin-like Polychlorinated Biphenyls Present in Blood and Breast Milk Induce Higher Levels of Reactive Oxygen Species in Neutrophil Granulocytes than High-Chlorinated Congeners.
    Basic Clin Pharmacol Toxicol 2016 Dec 12;119(6):588-597. Epub 2016 Jun 12.
    Department of Biochemistry, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
    Despite their ban several decades ago, polychlorinated biphenyls (PCBs) still pose a health threat to human beings due to their persistent and accumulative nature and continued presence in the environment. Non-dioxin-like (NDL)-PCBs have earlier been found to have effects on the immune system, including human neutrophil granulocytes. The aim of this study was to investigate the differences between ortho-chlorinated NDL-PCBs with a low or high degree of chlorination in their capability to induce the production of reactive oxygen species (ROS) in human neutrophil granulocytes in vitro. Read More

    The Combination of α-Tocopheryl Succinate and Sodium Selenite on Breast Cancer: A Merit or a Demerit?
    Oxid Med Cell Longev 2016 29;2016:4741694. Epub 2016 Mar 29.
    Pharmacology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo 11796, Egypt.
    α-Tocopheryl succinate (α-TOS), a mitochondria-targeting agent, induces apoptosis in malignant cells in vitro and in vivo. Selenite is a nutritional supplement that has been shown to stimulate apoptosis in cancer cells. This study was designed to investigate the cytotoxic effect of combined treatment of α-TOS and sodium selenite (SSe) in vitro and in vivo and to explore their effect on apoptosis and autophagy in breast cancer. Read More

    Target delivery of small interfering RNAs with vitamin E-coupled nanoparticles for treating hepatitis C.
    Sci Rep 2016 Apr 26;6:24867. Epub 2016 Apr 26.
    Department of Laboratory Medicine, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
    RNA interference (RNAi) represents a promising strategy for the treatment of HCV infection. However, the development of an effective system for in vivo delivery of small interfering RNA (siRNA) to target organ remains a formidable challenge. Here, we develop a unique nanoparticle platform (VE-DC) composed of α-tocopherol (vitamin E) and cholesterol-based cationic liposomes (DOTAP-Chol) for systemic delivery of siRNAs to the liver. Read More

    Fipronil sulfone induced higher cytotoxicity than fipronil in SH-SY5Y cells: Protection by antioxidants.
    Toxicol Lett 2016 Jun 8;252:42-9. Epub 2016 Apr 8.
    Department of Toxicology and Pharmacology, Faculty of Veterinary Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain.
    Fipronil is a broad spectrum insecticide from the phenyl pyrazole family, which targets GABA receptor. Limited information is available about the metabolite fipronil sulfone cytotoxic actions. This study examined in vitro neurotoxicity of fipronil and fipronil sulfone and evaluated Trolox (vitamin E analog) (0. Read More

    Synthesis of the vitamin E amino acid esters with an enhanced anticancer activity and in silico screening for new antineoplastic drugs.
    Eur J Pharm Sci 2016 Jun 8;88:59-69. Epub 2016 Apr 8.
    University of Belgrade, Faculty of Pharmacy, Institute of Pharmaceutical Chemistry, Vojvode Stepe 450, 11000 Belgrade, Serbia.
    Tocopherols and tocotrienols belong to the family of vitamin E (VE) with the well-known antioxidant properties. For certain α-tocopherol and γ-tocotrienol derivatives used as the lead compounds in this study, antitumor activities against various cancer cell types have been reported. In the course of the last decade, structural analogs of VE (esters, ethers and amides) with an enhanced antiproliferative and proapoptotic activity against various cancer cells were synthesized. Read More

    Titanium dioxide nanoparticles (100-1000 mg/l) can affect vitamin E response in Arabidopsis thaliana.
    Environ Pollut 2016 Jun 6;213:957-65. Epub 2016 Apr 6.
    Department of Plant Physiology and Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Gronostajowa 7, 30-387 Krakow, Poland.
    In the present study we analyze the effect of seed treatment by a range of nano-TiO2 concentrations on the growth of Arabidopsis thaliana plants, on the vitamin E content and the expression of its biosynthetic genes, as well as activity of antioxidant enzymes and lipid peroxidation. To conduct the mechanistic analysis of nano-TiO2 on plants growth and antioxidant status we applied nanoparticles concentrations that are much higher than those reported in the environment. We find that as the concentration of nano-TiO2 increases, the biomass, and chlorophyll content in 5-week-old Arabidopsis thaliana plants decrease in a concentration dependent manner. Read More

    The potential neurotoxicity of emerging tetrabromobisphenol A derivatives based on rat pheochromocytoma cells.
    Chemosphere 2016 Jul 4;154:194-203. Epub 2016 Apr 4.
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Tetrabromobisphenol A (TBBPA) can cause diverse adverse effects including neurotoxicity. Emerging TBBPA derivatives, with high structure similarity to the parent compound, are now being concerned. In this study, the potential neurotoxicities of four TBBPA derivatives and their parent compound were studied by cell viability inhibition in rat pheochromocytoma cells (PC12) and the corresponding molecular mechanisms were investigated. Read More

    Protective Effects of Selenium, Vitamin E, and Purple Carrot Anthocyanins on D-Galactose-Induced Oxidative Damage in Blood, Liver, Heart and Kidney Rats.
    Biol Trace Elem Res 2016 Oct 30;173(2):433-42. Epub 2016 Mar 30.
    State Key Laboratory of Food Science and Technology, University of Nanchang, Nanchang, Jiangxi, 330047, China.
    The present study was performed to investigate the protective effects of selenium (Se), vitamin E (Vit E) and anthocyanins from purple carrots and their combination against the oxidative stress induced by D-galactose in rats. A total of 80 male rats were equally divided into 11 groups, one of which acted as control (I) just receiving intraperitoneal injections of physiological saline. The remaining ten groups (II-XI) were intraperitoneally injected with D-galactose at a dose of 400 mg kg(-1) body weight (BW) per day for 42 consecutive days. Read More

    Lemna minor tolerance to metal-working fluid residues: implications for rhizoremediation.
    Plant Biol (Stuttg) 2016 Jul 13;18(4):695-702. Epub 2016 Apr 13.
    Department of Pharmaceutical & Health Sciences, Facultad Farmacia, Urb. Monteprincipe, Universidad San Pablo CEU, Madrid, Spain.
    For the first time in the literature, duckweed (Lemna minor) tolerance (alone or in combination with a consortium of bacteria) to spent metal-working fluid (MWF) was assessed, together with its capacity to reduce the chemical oxygen demand (COD) of this residue. In a preliminary study, L. minor response to pre-treated MWF residue (ptMWF) and vacuum-distilled MWF water (MWFw) was tested. Read More

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