Changes in hepatic gene expression and serum metabolites after oral administration of overdosed vitamin-E-loaded nanoemulsion in rats.
- Chae Young Park,
- Chul Ho Jang,
- Do Yup Lee,
- Hyung Taek Cho,
- Young Jun Kim,
- Yoo Heon Park,
- Jee-Young Imm
Food Chem Toxicol 2017 Sep 15. Epub 2017 Sep 15.
Department of Foods and Nutrition, Kookmin University, Seoul, South Korea. Electronic address:
Vitamin-E-loaded nanoemulsion (Vit E-NE) was produced, and the effects of repeated oral administration of Vit E-NE (2 g/kg/day) for five days on hepatic gene expression and serum metabolites were investigated in rats. The mean particle diameter and zeta potential of Vit E-NE was 112 nm and 56 mV, respectively. Vit E-NE administered rats showed significantly higher triglyceride content than of standard diet (control) or Vit E control emulsion (Vit E-CE) group but no toxicity symptoms were found in blood biochemical analysis. Read More