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Comp Biochem Physiol C Toxicol Pharmacol 2019 Apr 17. Epub 2019 Apr 17.

Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand; Science and Technology Research Institute, Chiang Mai University, 239 Huay keaw Rd., Suthep, Muang, Chiang Mai 50200, Thailand. Electronic address:

The present study evaluated silver nanoparticle (AgNPs) toxicity using biomarkers of oxidative and metabolic stress, immunological impairment and cellular damage in zebrafish (Danio rerio), as well as the optimal dose of vitamin E neutralizing undesirable effects. Fish were fed for ten days and eight study groups were investigated: controls, AgNPs exposure alone (1.5 mg L) and combined with three different vitamin E doses (1. Read More

J Vector Borne Dis 2018 Oct-Dec;55(4):282-290

World Health Organization, SEARO, New Delhi, India.

Background & Objectives: Vector control strategies play significant role in reducing the transmission of malaria, dengue and other vector-borne diseases. The control of vector population using synthetic insecticides has resulted in development of insecticide resistance and negative effects on humans and environment. The present investigation evaluated the larvicidal potential of methanol, dichloromethane and hexane extracts of leaves and seeds of Ricinus communis (castor) plant against the early IV instar larvae of the dengue vector, Aedes aegypti, and malaria vector, Anopheles culicifacies. Read More

Andrologia 2019 Apr 17:e13292. Epub 2019 Apr 17.

Faculty of Medicine, Department of Biostatistics, Inonu University, Malatya, Turkey.

Thirty rats, with confirmed pregnancies by vaginal smear, were divided into five groups, each including six rats, as the Control, Corn Oil, Vitamin E, Acrylamide, Vitamin E + Acrylamide groups. The births were monitored on the 21st day to select the male rats, and the selected male rats were decapitated at the end of the 8th week. Oxidant-antioxidant parameters, serum hormone levels and histopathological examinations were performed on testis tissues of the rats. Read More

Respir Res 2019 Apr 16;20(1):76. Epub 2019 Apr 16.

International Collaborative Laboratory for Air Pollution Health Effects and Intervention, School of Public Health, Xinxiang Medical University, 601 Jinsui Street, Xinxiang, 453003, Henan Province, China.

Background: Exposure to fine particulate matter (PM) has been associated with respiratory morbidity and mortality. Identification of interventional measures that are efficacious against PM-induced toxicity may provide public health benefits. This study examined the inhibitory effects of nutritional supplementation with fish oil as a source of omega-3 fatty acids and vitamin E (Vit E) on PM-induced lung toxicity in rats. Read More

Environ Int 2019 Apr 10;127:503-513. Epub 2019 Apr 10.

Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, USA.

Background: Mechanisms underlying the effects of traffic-related air pollution on people with asthma remain largely unknown, despite the abundance of observational and controlled studies reporting associations between traffic sources and asthma exacerbation and hospitalizations.

Objectives: To identify molecular pathways perturbed following traffic pollution exposures, we analyzed data as part of the Atlanta Commuters Exposure (ACE-2) study, a crossover panel of commuters with and without asthma.

Methods: We measured 27 air pollutants and conducted high-resolution metabolomics profiling on blood samples from 45 commuters before and after each exposure session. Read More

J Pharm Bioallied Sci 2019 Jan-Mar;11(1):43-48

Department of Pharmacy, Faculty of Pharmacy, University of Lahore, Lahore, Punjab, Pakistan.

Objective: The aim and objective of this study was to find the immunostimulant and immunomodulatory effect of seed extracts.

Methods: Seeds of were extracted using three different solvents -hexane, chloroform, and methanol by using soxhlet apparatus. To assess the immunomodulatory effect, delayed-type hypersensitivity (DTH) assay method was used and by the DTH assay, the effect of on the skin thickness of rats was estimated. Read More

Mol Biol Rep 2019 Mar 18. Epub 2019 Mar 18.

School of Medicine, Hamadan University of Medical Sciences, Hamadan, 65178, Iran.

The increasing application of titanium dioxide nanoparticles (NTiO) in life and the toxicity potential of these nanoparticles have raised concerns about their detrimental effects on human health. This study was conducted to investigate the hepatoprotective effects of vitamin E and vitamin A against hepatotoxicity induced by NTiO in rats. Thirty-six male Wistar rats were randomly divided into six groups of six rats each. Read More

Int J Nanomedicine 2019 18;14:1255-1268. Epub 2019 Feb 18.

College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, People's Republic of China,

Background: Combination therapy employing siRNAs and antitumor drugs is a promising method for the treatment of solid tumors. However, regarding combined treatments involving siRNAs and chemotherapeutic reagents, most prior research has focused on the enhanced cytotoxicity against tumor cells conferred by downregulation of the targeted protein.

Purpose: We developed D-α-tocopherol polyethylene glycol 1000 succinate (TPGS)-modified cationic liposomes (LPs) to simultaneously deliver doxorubicin (Dox) and the Bcl-2 siRNA (siBcl-2) for synergistic chemotherapy. Read More

Niger J Physiol Sci 2018 Dec 30;33(2):183-189. Epub 2018 Dec 30.

Department of Nursing, College of Nursing and Midwifery Sciences, Sokoto.

Cyanide is a potent neurotoxic substance that can initiate series of intracellular reactions leading to oxidativestress. To evaluate effect of sublethal administration of potassium cyanide (KCN) on sensorimotor functions and long termvisuo-spatial learning and memory in adult Swiss mice and possible ameliorative role of vitamins A and E. These vitaminsA and E (dietary) are antioxidants that have scavenging properties against free radicals and reactive oxygen species as aresult of oxidative stress induced by cyanide. Read More

Int J Mol Sci 2019 Mar 1;20(5). Epub 2019 Mar 1.

GRET-Toxicology Unit, Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain.

The developing cardiovascular system of zebrafish is a sensitive target for many environmental pollutants, including dioxin-like compounds and pesticides. Some polychlorinated biphenyls (PCBs) can compromise the cardiovascular endothelial function by activating oxidative stress-sensitive signaling pathways. Therefore, we exposed zebrafish embryos to PCB126 or to several redox-modulating chemicals to study their ability to modulate the dysmorphogenesis produced by PCB126. Read More

Appl Physiol Nutr Metab 2019 Feb 25. Epub 2019 Feb 25.

3Higher Institute of Applied Biology ISBAM Medenine 4119, University of Gabes, Tunisia., Gafsa, None Selected, Tunisia ;

Nicotine (NT) is a potential inducer of oxidative stress, through which it can damage numerous biological molecules. Natural antioxidants that prevent or slow the progression and severity of nicotine toxicity may have a significant health impact. The purpose of this study, conducted on Wistar rats, was to evaluate the beneficial effects of green tea (Camellia sinensis) extract on nicotine treatment induced damage on kidney. Read More

Food Chem Toxicol 2019 Apr 7;126:34-40. Epub 2019 Feb 7.

Department of Biochemistry, University of Allahabad, Allahabad, 211002, India. Electronic address:

Metanil yellow, an azo dye, is a non-permitted synthetic food colour used extensively in India and other developing countries as food additive. Present communication reports the toxic effects of metanil yellow on hepatic and kidney tissues and its amelioration by eugenol, vitamin E and vitamin C. Oral administration of metanil yellow in albino Wistar rats for 28 days caused elevation in serum enzymes (glutamate oxaloacetate transaminase, gluatamate pyruvate transaminase, alkaline phosphatase), and total bilirubin along with decline in albumin and total protein levels. Read More

Ecotoxicol Environ Saf 2019 May 19;172:33-39. Epub 2019 Jan 19.

Department of Food Science and Engineering, Moutai Institute, Renhuai 564507, China; Laboratory of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University, Wuhan 430079, China. Electronic address:

Exposure to specific air pollutants has been demonstrated to induce damage in the brain. However, these studies ignore the effects of a combination of contaminants, and there is a high likelihood that people will be exposed to a mixture of contaminants in daily life. Our previous study showed that co-exposure to formaldehyde (FA) and PM2. Read More

Hum Exp Toxicol 2019 May 10;38(5):547-560. Epub 2019 Jan 10.

2 Department of Biology, Faculty of Arts and Science, Bozok University, Divanliyolu/Yozgat, Turkey.

Lipopolysaccharide (LPS) as an endotoxin forms part of the cell wall of gram-negative bacteria and is responsible for initiating an acute inflammation after entering the living tissue. In this study, male rats were divided into eight groups: control group, vitamin E (VE) treatment group (200 mg/kg body weight (b.w. Read More

J Toxicol Sci 2019 ;44(1):35-45

Laboratory of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, China.

Due to its excellent properties such as ultraviolet obscuration, chemical stability and small particle size, nano-titanium dioxide (nano-TiO) is widely used, particularly in sunblock products. The skin is therefore a chief route for exposure. Studies have found that oral or respiratory exposure to nano-TiO has an adverse impact on the cardiovascular system. Read More

J Ethnopharmacol 2019 Apr 2;234:44-56. Epub 2019 Jan 2.

Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China. Electronic address:

Ethnopharmacological Relevance: Chrysanthemum indicum Linne (C. indicum), a healthy food and folk medicine in China for thousands of years, has been reported to exert heat-clearing and detoxifying effects and extensively applied to treat various symptoms such as inflammation diseases, hepatitis and headache.

Aim Of This Study: The purpose of the present study was to investigate the protective effect of the supercritical carbon dioxide fluid extract from flowers and buds of C. Read More

Wei Sheng Yan Jiu 2018 Nov;47(6):956-962

Department of Internal Medicine, College of Clinical Medicine, Hubei University of Science and Technology, Xianning 437100, China.

Objective: To investigate the role of extracellular regulated protein kinase( ERK) pathway activation in the testicular injury induced by dibutyl phthalate( DBP) in KM mice.

Methods: A total of fifty-six male KM mice were randomly divided into 8 groups: control group, 50 mg/( kg·d) DBP group, 50 mg/( kg·d) vitamin E( VE)group, 2 mg/( kg·d) nimodipine( Ni) group, DBP + VE group, DBP + Ni group, Ni +VE group and DBP + Ni + VE group. After consecutive 28 days of treatment, the body weight, testis weight, organ coefficient and sperm density of mice were measured. Read More

Drug Des Devel Ther 2018 13;12:4231-4240. Epub 2018 Dec 13.

Department of Anesthesiology, Affiliated Hospital of Jining Medical University, Jining, Shandong 272000, People's Republic of China,

Purpose: Transdermal drug delivery of local anesthetics using lipid nanoparticles could enhance lipophilic drugs permeation through the stratum corneum, improve drug diffusion to deeper skin, and exert good therapeutic effects. The purpose of this study was to engineer a Tocopheryl Polyethylene Glycol 1000 Succinate (TPGS)-modified cationic nanostructured lipid carriers (NLC) for the delivery of lidocaine (LID; TPGS/LID-NLC).

Materials And Methods: TPGS/LID-NLC was prepared by solvent diffusion method. Read More

Food Chem 2019 Apr 30;278:795-804. Epub 2018 Nov 30.

Laboratory of Biology of Plants and Microorganisms, Department of Biology, Faculty of Science, University Mohammed First, 717, 60000 Oujda, Morocco.

Anisophyllea boehmii is an indigenous and wild species in Burundi. Its fruits are edible and commercialized in local markets. This study investigates chemical quality, composition and toxicity test of A. Read More

Semin Radiat Oncol 2019 01;29(1):55-61

Division of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, AR.

Despite advances in radiation delivery techniques, side effects of radiation therapy due to radiation exposure of normal tissues are common and can limit the deliverable dose to tumors. Significant interests lie in pharmacologic modifiers that may protect against normal tissue toxicity from cancer treatment while simultaneously enhancing the tumor response to therapy. While no such treatments are available in the clinic, this is an area of active preclinical and clinical research. Read More

Int J Nanomedicine 2018 23;13:7931-7938. Epub 2018 Nov 23.

Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia,

Objective: The objective of this study was to verify and confirm the oxidative-mediated hepatotoxicity, inflammatory liver damage, and oxidative stress induced by intraperitoneal administration of gold nanoparticles (GNPs) in vivo; characterize the effect of different natural antioxidants on these hazardous changes; and finally choose the most powerful antioxidant among these different natural antioxidants.

Methods: Ten-nanometer GNPs were dissolved in aqueous solution of 0.01% concentration. Read More

Front Pharmacol 2018 26;9:1358. Epub 2018 Nov 26.

Product Development and Advisory Services Division, Malaysian Palm Oil Board, Bandar Baru Bangi, Malaysia.

Plant-derived phytonutrients have emerged as health enhancers. Tocotrienols from the vitamin E family gained high attention in recent years due to their multi-targeted biological properties, including lipid-lowering, neuroprotection, anti-inflammatory, antioxidant, and anticancer effects. Despite well-defined mechanism of action as an anti-cancer agent, their clinical use is hampered by poor pharmacokinetic profile and low oral bioavailability. Read More

Int J Nanomedicine 2018 15;13:7533-7548. Epub 2018 Nov 15.

Interventional Cancer Institute of Chinese Integrative Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, People's Republic of China,

Background: Multidrug resistance (MDR) is the major reason for the failure of chemotherapy in colon cancer. Bufalin (BU) is one of the most effective antitumor active constituents in Chansu. Our previous study found that BU can effectively reverse P-glycoprotein (P-gp)-mediated MDR in colon cancer. Read More

Ecotoxicol Environ Saf 2019 Apr 6;170:246-252. Epub 2018 Dec 6.

Department of Aquaculture, Sichuan Agricultural University, Wenjiang, Sichuan 611130, China.

Cadmium (Cd) pollution is an important issue affecting the food safety of aquatic products. Cd can impair the immune system and cause irreversible damage to fish and other aquatic organisms. The immunoprotection activities of exogenous metallothionein (MT) and vitamin E (VE) were investigated in Cd poisoned grass carp, Ctenopharyngodon idellus, in the present study. Read More

Biomed Res Int 2018 4;2018:7935396. Epub 2018 Nov 4.

Department of Aquaculture, College of Animal Science & Technology, Sichuan Agricultural University, WenJiang 611130, Sichuan, China.

Cadmium (Cd) causes a broad spectrum of toxicological effects to animals. Aquatic animals were more likely to accumulate Cd than terrestrial animals because of the living environment. Clearance of Cd in aquatic animals has become an important part of aquatic food safety. Read More

Fish Shellfish Immunol 2019 Mar 28;86:420-428. Epub 2018 Nov 28.

Chemistry of Natural Products Laboratory, Biotechnology and Biochemistry Department, Centro de Investigación y de Estudios Avanzados del IPN (CINVESTAV-IPN), Irapuato, Gto., Mexico.

Chenopodium ambrosioides L. has been used for centuries as traditional medicine in many clinical situations. The objectives of this study were first to assess the nutraceutical potential of C. Read More

Folia Neuropathol 2018 ;56(3):215-228

M1 muscarinic receptor plays a fundamental role in memory and is closely associated with Alzheimer's disease (AD); it has long been assumed as a therapeutic goal. By activating of the cholinergic receptor vitamin E helps with memory retention. But effects of vitamin E on density of M1 muscarinic receptor-immunoreactive (ir) neurons remain poorly understood. Read More

Int J Nanomedicine 2018 25;13:6855-6870. Epub 2018 Oct 25.

Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China,

Purpose: Liver cancer is the third leading cause of cancer-related deaths worldwide. Liver cancer stem cells (LCSCs) are a subpopulation of cancer cells that are responsible for the initiation, progression, drug resistance, recurrence, and metastasis of liver cancer. Recent studies have suggested that the eradication of both LCSCs and liver cancer cells is necessary because the conversion of cancer stem cells (CSCs) to cancer cells occasionally occurs. Read More

Plant Foods Hum Nutr 2019 Mar;74(1):76-82

Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253, Bragança, Portugal.

Fruits are one of the most promising food matrices and they have been explored in the discovery of new natural and safer bioactive compounds. Carissa macrocarpa (Eckl.) A. Read More

Front Biosci (Elite Ed) 2019 01 1;11:121-129. Epub 2019 Jan 1.

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India.

The objective of the present study was to investigate the effects of troxerutin (TX) on N-nitro-L-arginine methyl ester hydrochloride (L-NAME) induced hypertension in male albino Wistar rats. L-NAME (40mg/kg body weight (bw)) administration caused a sustained increase in systolic blood pressure (SBP), levels of thiobarbituric acid reactive substances (TBARS), lipid hydroperoxides (LOOH), tissue lipids (liver and kidney) such as total cholesterol (TC), triglycerides (TG), free fatty acids (FFA), and significant decrease in the activities of enzymatic antioxidants, phospholipids (PL) and levels of non enzymatic antioxidants such as reduced glutathione (GSH), vitamin C and vitamin E. To assess the toxicity if any of TX treatment, hepatic and renal function markers were measured. Read More

Environ Sci Pollut Res Int 2018 Nov 21. Epub 2018 Nov 21.

Laboratoire d'Ecophysiologie Animale, Faculté des Sciences de Sfax, 3018, Sfax, Tunisia.

The purpose of this study was to investigate, for the first time, the effects of Bifenthrin (Bif) chronic exposure on plasmatic and aortic lipid parameters disturbance and their pro-atherogenic possibility in Wistar rats. The ameliorative role of vitamin E (Vit E) and selenium (Se) were also targeted. Thus, rats were treated by gastric gavage with combination of Vit E (100 mg/kg/bw) and Se (0. Read More

Biol Trace Elem Res 2018 Nov 21. Epub 2018 Nov 21.

Polish Academy of Sciences, Institute of Low Temperature and Structure Research, Okolna 2, 50-422, Wroclaw, Poland.

This paper focuses on negative effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on element content in male chicken calvaria and α-tocopherol (vitamin E) ability to reduce its toxic potential on bone mineralization in offspring. In the experiment carried out once, a solution containing only DMSO, TCDD, TCDD + α-tocopherol, and exclusively α-tocopherol was administrated. Subsequently, on the 5th day after hatching, the mineral composition of the chicken calvaria was evaluated. Read More

Bioorg Med Chem Lett 2019 Jan 2;29(1):107-114. Epub 2018 Nov 2.

Department of Chemistry and Biochemistry, University of Windsor, Windsor, Ontario, Canada. Electronic address:

The production and use of multi-modal imaging agents is on the rise. The vast majority of these imaging agents are limited to a single length scale for the agent (e.g. Read More

Physiol Res 2019 03 23;68(1):67-74. Epub 2018 Oct 23.

Department of Zoology, Lahore College for Women University, Lahore, Pakistan.

Current study evaluated the synergistic potential of propolis and vitamin E against sub-acute toxicity of aluminum chloride on different biochemical parameters and liver histology. Swiss albino mice (n=42) were randomly divided into seven groups. Group I received 0. Read More

Neurotox Res 2019 Feb 29;35(2):451-462. Epub 2018 Oct 29.

Department of Clinical Pharmacology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Phenytoin is one of the most well-known antiepileptic drugs that cause cognitive impairment which is closely related to cAMP response element-binding protein (CREB) brain-derived neurotrophic factor (BDNF) signaling pathway. Moreover, vascular endothelial growth factor (VEGF), an endothelial growth factor, has a documented role in neurogenesis and neuronal survival and cognitive impairment. Therefore, this study aimed to investigate the influence of powerful antioxidants: α-Toc and CoQ10 alone or combined in the preservation of brain tissues and the maintenance of memory formation in phenytoin-induced cognitive impairment in rats. Read More

Environ Health Prev Med 2018 Oct 24;23(1):51. Epub 2018 Oct 24.

Environmental Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, P.O. Box: 6618634683, Sanandaj, Iran.

Background: Study of antioxidant vitamin consumption behavior, especially in high-risk groups with high exposure to toxic metals to reduce metal toxicity, is emphasized. This study aims to examine the structural relationships between knowledge, protection motivation theory constructs, and vitamin E and C consumption behavior among cement factory workers.

Methods: Protection motivation theory and food frequency questionnaires were completed by 420 factory workers. Read More

Environ Pollut 2019 Jan 4;244:295-303. Epub 2018 Oct 4.

Department of Biological Sciences, GRIL-TOXEN, Ecotoxicology of Aquatic Microorganisms Laboratory, Université du Québec à Montréal, Succ. Centre-Ville, Montréal, Québec, Canada. Electronic address:

Mesotrione, an herbicide increasingly found in aquatic systems due to its increased application frequency in corn fields, is an inhibitor of the p-hydroxyphenylpyruvate dioxygenase (HPPD), a key enzyme for plastoquinone-9, α-tocopherol and indirectly for carotenoid biosynthesis. The direct effect of mesotrione on plastoquinone-9 and α-tocopherol synthesis and their degradation rates are well documented, but few information exists on its action on photosynthetic processes under various light intensities. We therefore investigated the photosynthetic activity, energy dissipation processes, pigment composition and α-tocopherol content when Chlamydomonas reinhardtii were exposed to mesotrione for 24 h under low light condition and then the impacts of HL treatment (75 min) were also investigated. Read More

Ecotoxicol Environ Saf 2019 Jan 13;167:161-168. Epub 2018 Oct 13.

Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400014 China; Department of Pediatric Urology Surgery, Children's Hospital of Chongqing Medical University, Chongqing 400014 China. Electronic address:

Long-term exposure to particulate matter 2.5 (PM) from automobile exhaust impairs spermatogenesis through oxidative stress injury, but the underlying mechanism is unknown. To investigate the toxic mechanism of PM-induced spermatogenesis impairment, we focused on the MAPK signaling pathway. Read More

Colloids Surf B Biointerfaces 2019 Jan 4;173:366-377. Epub 2018 Oct 4.

Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (BHU), Varanasi, 221005, India. Electronic address:

Breast cancer, up-regulated with human epidermal growth factor receptor type-2 (HER-2) has led to the concept of developing HER-2 targeted anticancer therapeutics. Docetaxel-loaded D-α-tocopherol polyethylene glycol 1000 succinate conjugated chitosan (TPGS-g-chitosan) nanoparticles were prepared with or without Trastuzumab decoration. The particle size and entrapment efficiency of conventional, non-targeted as well as targeted nanoparticles were in the range of 126-186 nm and 74-78% respectively. Read More

Colloids Surf B Biointerfaces 2019 Jan 5;173:346-355. Epub 2018 Oct 5.

Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, China. Electronic address:

This work has presented a novel strategy for designing pH-sensitive TOS-H-DOX prodrug-loaded TPGS nanomicelles for co-delivery TOS and DOX to enhance tumor therapy and reduce the toxic side effects. DOX was covalently conjugated to the vitamin E succinate through hydrazone bond to produce an pH-sensitive prodrug TOS-H-DOX (amido bond as a control, TOS-A-DOX), which was responsive to the acidic environment in tumor cells, and the prodrugs were subsequently encapsulated in the core of TPGS nanomicelles via hydrophobic effects with a significant drug loading capacity. The pH-sensitive prodrug nanomicelles TOS-H-DOX/TPGS exhibited potent release of DOX in acidic media relative to the pH-insensitive prodrug nanomicelles TOS-A-DOX/TPGS, and further studies of their intracellular uptake and intracellular localization demonstrated that TOS-H-DOX/TPGS nanomicelles can be effectively taken up by cells and drugs can be released. Read More

Ecotoxicol Environ Saf 2019 Jan 10;167:114-121. Epub 2018 Oct 10.

Shanghai Key Lab of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China. Electronic address:

Emamectin benzoate (EMB) toxicity contributes a potential risk to environment and human health. To investigate the effect of α-tocopherol (VitE) and dithiothreitol (DTT) in ameliorating EMB-induced cytotoxicity in human K562 cells, in vitro cultured human K562 cells were incubated with different concentrations of EMB in supplement with VitE and DTT when the cells were in the logarithmic phase. Next, the cell growth inhibition was evaluated using the MTT assay and cellular morphology observation. Read More

Appl Physiol Nutr Metab 2019 May 11;44(5):521-527. Epub 2018 Oct 11.

a Pharmaceutical Science Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran.

Ethanol is the most widely abused drug in the world and its long-term use induces oxidative stress in the liver tissue. The aim of this study was to evaluate protective effect of against ethanol-induced hepatotoxicity in Wistar rat. Animals were divided into 9 groups as follows: control (normal saline), ethanol (10 mg/kg, intraperitoneally), ethanol with 3 doses (125, 250, and 500 mg/kg) of ethyl acetate flower and leaf extracts, and positive control (vitamin E 80 mg/kg). Read More

Int J Mol Sci 2018 Oct 4;19(10). Epub 2018 Oct 4.

Hunan Key Laboratory of Grain-Oil Deep Process and Quality Control, Hunan Key Laboratory of Processed Food for Special Medical Purpose, College of Food Science and Engineering, National Engineering Laboratory for Deep Process of Rice and Byproducts, Central South University of Forestry and Technology, Changsha 410004, Hunan, China.

δ-Tocotrienol, an important component of vitamin E, has been reported to possess some physiological functions, such as anticancer and anti-inflammation, however their molecular mechanisms are not clear. In this study, δ-tocotrienol was isolated and purified from rice bran. The anti-inflammatory effect and mechanism of δ-tocotrienol against lipopolysaccharides (LPS) activated pro-inflammatory mediator expressions in RAW264. Read More

Int J Toxicol 2018 Sep/Oct;37(2_suppl):61S-94S

4 Cosmetic Ingredient Review Executive Director, Cosmetic Ingredient Review, Washington, DC, USA.

The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) assessed the safety of 14 tocopherols and tocotrienols and concluded these ingredients are safe as used in cosmetics. The tocopherols are reported to function in cosmetics as antioxidants or skin-conditioning agents; in contrast, tocotrienols are not reported to function as an antioxidants in cosmetics but as a light stabilizer, oral care agent, or skin-conditioning agent. The Panel reviewed the new and existing animal and clinical data to determine the safety of these ingredients and found it appropriate to extrapolate the existing information to conclude on the safety of all the tocopherols and tocotrienols. Read More

Int J Pharm 2018 Nov 14;551(1-2):177-183. Epub 2018 Sep 14.

College of Pharmacy, Liaoning University, Shenyang 110036, PR China. Electronic address:

This study aimed at investigating the potential mechanism of improved transportation of the curcumin loaded D-α-tocopherol polyethylene glycol 1000 succinate coated nanodiamonds system (NDs/CUR/TPGS complexes) using an in vitro Caco-2 cell monolayer model. The core-shell structured NDs/CUR/TPGS nanocomplexes were 196.32 ± 5. Read More

Int J Pharm 2018 Nov 7;551(1-2):34-41. Epub 2018 Sep 7.

Dept. of Scienze della Vita e dell'Ambiente, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy.

Transfersomes were prepared by using different polysorbates (i.e., Tween 20, 40, 60 and 80) and loaded with tocopherol acetate, a naturally-occurring phenolic compound with antioxidant activity. Read More

Zhonghua Nan Ke Xue 2018 Jul;24(7):589-595

Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.

Objective: To explore the antagonistic effect of vitamin E (VE) on male reproductive toxicity induced by di-2-ethylhexyl phthalate (DEHP) in pubertal SD rats and its underlying mechanisms.

Methods: Thirty 5-week-old male SD rats were randomly divided into five groups of equal number, corn oil control, low-dose (10 mg/kg/d), medium-dose (100 mg/kg/d) and high-dose DEHP exposure (500 mg/kg/d), and VE intervention (high-dose DEHP + VE ［100 mg/kg/d］), and treated respectively for 30 successive days. At 3 days after treatment, the testes of the animals were harvested for determination of the oxidative stress index, serum reproductive hormone levels, cauda epididymal sperm parameters, and expressions of cell apoptosis-related genes and proteins. Read More

Colloids Surf B Biointerfaces 2018 Dec 20;172:170-179. Epub 2018 Aug 20.

Department of Biomedical Engineering and Center for Marine-Integrated Biomedical Technology (BK 21 Plus), Pukyong National University, Busan, South Korea; Interdisciplinary program of Biomedical Mechanical & Electrical Engineering, Pukyong National University, Busan, South Korea. Electronic address:

Emulsion-based delivery systems have been fabricated and developed to increase the bioavailability of astaxanthin and alpha-tocopherol as active compounds for various biomedical applications. Astaxanthin-alpha tocopherol nanoemulsion (ATNE) is well known for its potential 6.-6. Read More

Med Pr 2018 Aug 10;69(4):403-412. Epub 2018 Jul 10.

Śląski Uniwersytet Medyczny w Katowicach / Medical University of Silesia in Katowice, Zabrze, Poland (Wydział Lekarski z Oddziałem Lekarsko-Dentystycznym w Zabrzu, Katedra Biochemii / School of Medicine with the Division of Dentistry in Zabrze, Department of Biochemistry)

Background: Fluorine influences many processes occurring in the organism. Controversies over the evaluation of the biological effects of this substance are due to a small difference between tolerable and toxic fluorine doses. One of the main mechanisms of the fluorine toxic action is its ability to induce oxidative stress via reactive oxygen species generation and antioxidant defense system impairment. Read More

J Pharmacopuncture 2018 Jun 30;21(2):61-69. Epub 2018 Jun 30.

Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: In this study, the effects of saffron stigma against subacute diazinon (DZN) toxicity on enzymes levels, biochemical, hematological, histopathological and genotoxicity indices were studied in rats.

Methods: Vitamin E (200 IU/kg) and the aqueous extract of saffron (50, 100 and 200 mg/kg) were injected intraperitoneally three times per week alone or with DZN (20 mg/kg/day, orally) for 4 weeks. The hematological and biochemical parameters were evaluated at the end of 4 weeks. Read More