Search our Database of Scientific Publications and Authors

I’m looking for a

    3650 results match your criteria Vitamin E Toxicity

    1 OF 73

    Enhancement of apoptotic activities on brain cancer cells via the combination of γ-tocotrienol and jerantinine A.
    Phytomedicine 2017 Jul 10;30:74-84. Epub 2017 Mar 10.
    School of Biosciences, Faculty of Science, The University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor, Malaysia; Biotechnology Research Centre, The University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor, Malaysia. Electronic address:
    Background: γ-Tocotrienol, a vitamin E isomer possesses pronounced in vitro anticancer activities. However, the in vivo potency has been limited by hardly achievable therapeutic levels owing to inefficient high-dose oral delivery which leads to subsequent metabolic degradation. Jerantinine A, an Aspidosperma alkaloid, originally isolated from Tabernaemontana corymbosa, has proved to possess interesting anticancer activities. Read More

    Potential Use of Chemoprotectants against the Toxic Effects of Cyanotoxins: A Review.
    Toxins (Basel) 2017 May 23;9(6). Epub 2017 May 23.
    Area of Toxicology, Faculty of Pharmacy, Universidad de Sevilla, Sevilla 41012, Spain.
    Cyanobacterial toxins, particularly microcystins (MCs) and cylindrospermopsin (CYN), are responsible for toxic effects in humans and wildlife. In order to counteract or prevent their toxicity, various strategies have been followed, such as the potential application of chemoprotectants. A review of the main substances evaluated for this aim, as well as the doses and their influence on cyanotoxin-induced toxicity, has been performed. Read More

    Protective Effects of Vitamin E against reproductive toxicity induced by di(2-ethylhexyl) phthalate via PPAR-Dependent Mechanisms.
    Toxicol Mech Methods 2017 May 22:1-27. Epub 2017 May 22.
    a Department of Urology , Children's Hospital of Chongqing Medical University , Chongqing , China.
    Objective: To investigate the protective/ameliorative effects of vitamin E on di-2-(ethylhexyl) phthalate (DEHP)-induced reproductive toxicity, particularly in testicular toxicity in male rats, emphasizing peroxisome proliferator-activated receptor (PPAR) -Dependent mechanism.

    Methods: Sprague-Dawley females were exposed by oral route to DEHP alone or associated with vitamin E from gestation day (GD) 12.5 to postnatal day (PND) 3 according to the following treatment regimens: vehicle control (corn oil), vitamin E (200 mg/kg) + corn oil, DEHP (500 mg/kg) + corn oil, and DEHP (500 mg/kg) + vitamin E (200 mg/kg) + corn oil. Read More

    Protective effect of ethanolic extract of Urtica urens L. against the toxicity of imidacloprid on bone remodeling in rats and antioxidant activities.
    Biomed Pharmacother 2017 May 16;91:1022-1041. Epub 2017 May 16.
    Research Unit of Histo-Embryology and Cytogenetic, Medicine Faculty, University of Sfax, 3029 Sfax, Tunisia.
    Imidacloprid (IMI) is very harmful to human health and cause problems. Recently, plants have been considered as potential agents for protection against these disorders. Urtica urens L. Read More

    Synergistic protective effect of FTY720 and vitamin E against simulated cerebral ischemia in vitro.
    Mol Med Rep 2017 May 11. Epub 2017 May 11.
    Key Laboratory for Corneal Tissue Engineering, College of Marine Life Sciences, Ocean University of China, Qingdao, Shandong 266003, P.R. China.
    The purpose of the present study was to explore the combination effect of FTY720 and vitamin E on cerebral ischemia. Astrocytes were isolated from newborn Sprague‑Dawley rats and were subjected to FTY720, vitamin E, or combination of the two. The astrocyte cultures were then exposed to oxygen‑glucose deprivation (OGD) to simulate an ischemic model in vitro. Read More

    Alterations in serum levels of selected markers of oxidative imbalance in adult celiac patients with extraintestinal manifestations - pilot study.
    Pol Arch Intern Med 2017 May 5. Epub 2017 May 5.
    INTRODUCTION    Oxidative stress is considered as one of the mechanisms responsible for gluten toxicity, but its role in celiac disease (CD) remains unclear.  OBJECTIVES    To evaluate oxidative imbalance in the pathomechanism of CD by determining the concentrations of nitric oxide (NO) and selected antioxidant parameters.  PATIENTS AND METHODS    The study involved 197 adult patients: 53 patients with untreated active CD, 92 celiac patients on gluten-free diet (GFD), and 52 controls. Read More

    Analogues of desferrioxamine B designed to attenuate iron-mediated neurodegeneration: synthesis, characterisation and activity in the MPTP-mouse model of Parkinson's disease.
    Metallomics 2017 May 3. Epub 2017 May 3.
    School of Medical Sciences (Pharmacology), and Bosch Institute, The University of Sydney, New South Wales 2006, Australia.
    Parkinson's disease (PD) is a neurodegenerative disorder characterised by the death of dopaminergic neurons in the substantia nigra pars compacta (SNpc) region of the brain and formation of α-synuclein-containing intracellular inclusions. Excess intraneuronal iron in the SNpc increases reactive oxygen species (ROS), which identifies removing iron as a possible therapeutic strategy. Desferrioxamine B (DFOB, 1) is an iron chelator produced by bacteria. Read More

    Ameliorative Effect of VE, IGF-I, and hCG on the Fluoride-Induced Testosterone Release Suppression in Mice Leydig Cells.
    Biol Trace Elem Res 2017 May 1. Epub 2017 May 1.
    College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi, 030801, People's Republic of China.
    Excessive consumption of fluoride (F) through drinking, eating, and/or environmental contaminants induces chronic toxicity known as fluorosis. Our previous research has shown that fluorosis was associated with male reproductive disorders. The current study is designed to explain the protective effect of vitamin E (VE), insulin-like growth factor-I (IGF-I), and human chorionic gonadotropin (hCG) against natrium fluoride (NaF)-induced alterations in isolated Leydig cells (LCs). Read More

    New amino acid-Schiff base derived from s-allyl cysteine and methionine alleviates carbon tetrachloride-induced liver dysfunction.
    Biochimie 2017 Apr 25. Epub 2017 Apr 25.
    Department of Biochemistry, Periyar University, Salem, Tamil Nadu 636011, India. Electronic address:
    In spite of the tremendous stride in modern medicine, conventional drugs used in the hepatotoxic management are mostly inadequate. The present study aims in the synthesis of novel Schiff base compound derived using s-ally cystiene and methionine. The newly synthesized compound, 2-((2-((2-(allylthio)-1-carboxyethyl)imino)ethylidene)amino)-4-(methylthio)butanoic acid (ACEMB) was characterized using UV-visible spectrophotometer, FTIR, (1)HNMR, and GC-MS. Read More

    Acetamiprid inhibits testosterone synthesis by affecting the mitochondrial function and cytoplasmic adenosine triphosphate production in rat Leydig cells.
    Biol Reprod 2017 01;96(1):254-265
    Department of Basic Medical Science, Zunyi Medical College, Zunyi Guizhou, People's Republic of China.
    The insecticide acetamiprid is used to control noxious agricultural pests. However, it can cause mammalian toxicity. We evaluated the reproductive toxicity of acetamiprid in adult male Sprague Dawley rats. Read More

    Radioprotective Effect of Beta D-Glucan and Vitamin E on Gamma Irradiated Mouse.
    J Clin Diagn Res 2017 Feb 1;11(2):TC08-TC11. Epub 2017 Feb 1.
    Professor, Department of Molecular Imaging and Radionuclide Therapy (MIRT), The Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences , Bushehr, Iran .
    Introduction: It is shown that beta-D-glucan is an immunologic system booster with radioprotectory effects. Radioprotectors are chemical components that can alleviate biological damage produced by ionizing radiation.

    Aim: This study was designed to investigate the synergistic radioprotectory effects of beta-D-glucan and vitamin E on irradiated mice with (60)Co source. Read More

    Pro-NP™ protect against TiO2 nanoparticle-induced phototoxicity in zebrafish model: exploring potential application for skin care.
    Drug Deliv Transl Res 2017 Jun;7(3):372-382
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
    Titanium dioxide nanoparticles (TiO2NPs) are used in sunscreen products to protect the skin from the sun's ultraviolet rays. However, following exposure to sunlight, the photocatalytic activity of TiO2NPs can produce an excess of reactive oxygen species (ROS), causing skin cell damage, triggering an inflammatory response. In zebrafish model, we evaluated how well Pro-NP™ (biodegradable NPs containing superoxide dismutase and catalase) could protect them from TiO2NP-induced photo-oxidative stress. Read More

    Customized Corneal Cross-Linking-A Mathematical Model.
    Cornea 2017 May;36(5):600-604
    *Corneal Transplant Center, Pellegrini Hospital, Naples, Italy; †Mercy Center for Corrective Eye Surgery, McHenry, IL; ‡Department of Pharmacy, University of Naples Federico II, Naples, Italy; §Department of Ophthalmology, Pellegrini Hospital, Naples, Italy; ¶Department of Ophthalmology, Salerno University Hospital, Salerno, Italy; and ‖Institute of Refractive and Ophthalmic Surgery (IROS), Naples, Italy.
    Purpose: To improve the safety, reproducibility, and depth of effect of corneal cross-linking with the ultraviolet A (UV-A) exposure time and fluence customized according to the corneal thickness.

    Methods: Twelve human corneas were used for the experimental protocol. They were soaked using a transepithelial (EPI-ON) technique using riboflavin with the permeation enhancer vitamin E-tocopheryl polyethylene glycol succinate. Read More

    Ochratoxin A cytotoxicity on Madin-Darby canine kidney cells in the presence of alpha-tocopherol: Effects on cell viability and tight junctions.
    J Anim Physiol Anim Nutr (Berl) 2017 Mar 1. Epub 2017 Mar 1.
    Department of Health, Animal Science and Food Safety, Università degli Studi di Milano, Milano, Italy.
    Ochratoxin A (OTA) is a potent nephrotoxic fungi metabolite that affects animal and human health. At the cellular level, OTA is able to alter functions and viability by several mechanisms of action. Several strategies to counteract its toxicity have been studied. Read More

    Protective Role of Tetrahydrocurcumin: an Active Polyphenolic Curcuminoid on Cadmium-InducedOxidative Damage in Rats.
    Appl Biochem Biotechnol 2017 Feb 24. Epub 2017 Feb 24.
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tami Nadu, 608002, India.
    In the present work, protective effect of tetrahydrocurcumin (THC) against oxidative damages in cadmium (Cd)-induced toxicity in rats was evaluated. Cd is an important environmental and industrial toxicant that affects almost all the organs, especially liver. Liver is the major organ responsible for the metabolism and the primary target for many toxic chemicals and drugs. Read More

    Multi-Omics Reveals that Lead Exposure Disturbs Gut Microbiome Development, Key Metabolites, and Metabolic Pathways.
    Chem Res Toxicol 2017 Apr 16;30(4):996-1005. Epub 2017 Mar 16.
    Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.
    Lead exposure remains a global public health issue, and the recent Flint water crisis has renewed public concern about lead toxicity. The toxicity of lead has been well established in a variety of systems and organs. The gut microbiome has been shown to be highly involved in many critical physiological processes, including food digestion, immune system development, and metabolic homeostasis. Read More

    Biologic Stress, Oxidative Stress, and Resistance to Drugs: What Is Hidden Behind.
    Molecules 2017 Feb 17;22(2). Epub 2017 Feb 17.
    Department of Pharmacy, School of Health Sciences, Frederick University, Nicosia 1036, Cyprus.
    Stress can be defined as the homeostatic, nonspecific defensive response of the organism to challenges. It is expressed by morphological, biochemical, and functional changes. In this review, we present biological and oxidative stress, as well as their interrelation. Read More

    Selenium- and Tellurium-Based Antioxidants for Modulating Inflammation and Effects on Osteoblastic Activity.
    Antioxidants (Basel) 2017 Feb 14;6(1). Epub 2017 Feb 14.
    Department of Engineering Science, Applied Materials Science, Uppsala University, Box 534, Uppsala 751 21, Sweden.
    Increased oxidative stress plays a significant role in the etiology of bone diseases. Heightened levels of H2O2 disrupt bone homeostasis, leading to greater bone resorption than bone formation. Organochalcogen compounds could act as free radical trapping agents or glutathione peroxidase mimetics, reducing oxidative stress in inflammatory diseases. Read More

    Co-delivery of paclitaxel and TOS-cisplatin via TAT-targeted solid lipid nanoparticles with synergistic antitumor activity against cervical cancer.
    Int J Nanomedicine 2017 31;12:955-968. Epub 2017 Jan 31.
    Department of Internal Medicine Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Science, Ji'nan, People's Republic of China.
    Background: Cervical cancer is a major world health problem for women. Currently, cancer research focuses on improving therapy for cervical cancer using various treatment options such as co-delivery of chemotherapeutic agents by nanocarriers.

    Purpose: The aim of this study was to develop trans-activating transcriptional activator (TAT)-modified solid lipid nanoparticles (SLNs) for co-delivery of paclitaxel (PTX) and α-tocopherol succinate-cisplatin prodrug (TOS-CDDP) (TAT PTX/TOS-CDDP SLNs) in order to achieve synergistic antitumor activity against cervical cancer. Read More

    Effects of copper on viability and functional properties of hippocampal neurons in vitro.
    Exp Toxicol Pathol 2017 Feb 8. Epub 2017 Feb 8.
    Research Center of Neurology, Moscow, Russia; Moscow State University, A.N. Belozersky Institute of Physico-Chemical Biology, Biological Faculty, Moscow, Russia. Electronic address:
    Copper (Cu(2+)) is an essential metal presented in the mammalian brain and released from synaptic vesicles following neuronal depolarization. However, the disturbance of Cu(2+) homeostasis results in neurotoxicity. In our study we performed for the first time a combined functional investigation of cultured hippocampal neurons under Cu(2+) exposure, its effect on spontaneous spike activity of hippocampal neuronal network cultured on multielectrode array (MEA), and development of long-term potentiation (LTP) in acute hippocampal slices in the presence of Cu(2+). Read More

    Vitamin E and selenium treatment of monocrotaline induced hepatotoxicity in rats.
    Biotech Histochem 2017 6;92(1):59-67. Epub 2017 Feb 6.
    a Departments of Histology and Embryology.
    Monocrotaline (MCT) is a hepatotoxic pyrrolizidine alkaloid that is derived from plants; exposure may occur by consumption of contaminated grains, herbal teas and medicines. MCT can cause liver damage. We investigated the antioxidant effects of selenium (Se) and vitamin E against the toxic effects of MCT. Read More

    p66shc-mediated toxicity of high-dose α-tocopherol in renal proximal tubule cells.
    J Physiol Biochem 2017 May 2;73(2):267-273. Epub 2017 Feb 2.
    Department of Pediatrics, Division of Pediatric Nephrology, University of Mississippi Medical Center, 2500 N State St, Jackson, MS, 39216, USA.
    α-Tocopherol (TOC) is a widely used supplement known for its role as an antioxidant. Previously, we have shown that TOC elicits adaptive responses by upregulating the ERK/CREB/HO-1 pathway, which depends on its concentration in cultured renal proximal tubule cells (RPTCs). This suggests that high-dose TOC (hTOC) may elicit adverse effects via inflicting oxidative stress. Read More

    Antioxidant effect of vitamin E and 5-aminosalicylic acid on acrylamide induced kidney injury in rats.
    Saudi Med J 2017 Feb;38(2):132-137
    Department of Anatomy, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia. E-mail.
    Objectives: To explore renal toxicity caused by sub-acute exposure of acrylamide and to study the protective effect of 5-Aminosalicylic acid (5-ASA) and Vitamin E (vit-E)on Acrylamide (ACR) induced renal toxicity. Methods: This study was conducted at King Fahad Medical Research Centre, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia, between August and November 2015. A total of 49 adult Wistar rats (250 ± 20g) aged 60 days were kept in a controlled environment and used in the present study. Read More

    Using vitamin E to prevent the impairment in behavioral test, cell loss and dendrite changes in medial prefrontal cortex induced by tartrazine in rats.
    Acta Histochem 2017 Mar 23;119(2):172-180. Epub 2017 Jan 23.
    Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Zand Ave., Shiraz 71348-45794, Iran; Anatomy Department, School of Medicine, Shiraz University of Medical Sciences, Zand Ave., Shiraz 71348-45794, Iran.
    Tartrazine is a food color that may adversely affect the nervous system. Vitamin E is a neuro-protective agent. This study aimed to evaluate the effects of tartrazine and vitamin E on the performance of rats in memory and learning tests as well as the structure of medial Prefrontal Cortex (mPFC). Read More

    α-Tocopherol at Nanomolar Concentration Protects Cortical Neurons against Oxidative Stress.
    Int J Mol Sci 2017 Jan 21;18(1). Epub 2017 Jan 21.
    Department of Molecular Endocrinology and Neurochemistry, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Thorez avenue, 44, Saint-Petersburg 194223, Russia.
    The aim of the present work is to study the mechanism of the α-tocopherol (α-T) protective action at nanomolar and micromolar concentrations against H₂O₂-induced brain cortical neuron death. The mechanism of α-T action on neurons at its nanomolar concentrations characteristic for brain extracellular space has not been practically studied yet. Preincubation with nanomolar and micromolar α-T for 18 h was found to increase the viability of cortical neurons exposed to H₂O₂; α-T effect was concentration-dependent in the nanomolar range. Read More

    Combined effects of vitamin E and omega-3 fatty acids on protecting ambient PM2.5-induced cardiovascular injury in rats.
    Chemosphere 2017 Apr 8;173:14-21. Epub 2017 Jan 8.
    Department of Environmental Health, School of Public Health and the Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai, 200032, China. Electronic address:
    Objective: This study aims to observe whether the combined treatment with vitamin E (vit E) and omega-3 polyunsaturated fatty acids (Ω-3 FA) could prevent the fine particulate matter (PM2.5)-induced cardiovascular injury through alleviating inflammation and oxidative stress. At the same time, the appropriate combination dosage of vit E and Ω-3 FA was explored to find an optimized protective dose to protect the injury induced by PM2. Read More

    Synthesis, characterization, and in-vitro antitumor activity of the polyethylene glycol (350 and 1000) succinate derivatives of the tocopherol and tocotrienol isomers of Vitamin E.
    Int J Pharm 2017 Mar 16;519(1-2):145-156. Epub 2017 Jan 16.
    College of Health and Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA, USA; College of Pharmacy, Taipei Medical University, Taipei, Taiwan. Electronic address:
    Vitamin E refers to a group of saturated tocopherol (T) isomers and the biologically more active unsaturated tocotrienol (T3) isomers. PEGylated α-tocopherol, commercially known as Vitamin E TPGS, has been used as an emulsifier and therapeutic agent for children with vitamin E deficiency. Limited information, however, is available about the PEG conjugates of the tocotrienol isomers of vitamin E. Read More

    Vitamin E reduces endosulfan-induced toxic effects on morphology and behavior in early development of zebrafish (Danio rerio).
    Food Chem Toxicol 2017 Mar 6;101:84-93. Epub 2017 Jan 6.
    National Institute of Nutrition and Seafood Research (NIFES), PO Box 2029, NO-5817 Bergen, Norway. Electronic address:
    The aim of this study was to investigate if vitamin E (α-TOC) modulates the developmental toxicity of the pesticide endosulfan (ESF), using a modified zebrafish embryotoxicity test (ZET). Zebrafish (Danio rerio) embryos were exposed from 6 to 72 h post fertilization (hpf) to either ESF (0.1-50 mg/L) or α-TOC (0. Read More

    CYP4F2 repression and a modified alpha-tocopherol (vitamin E) metabolism are two independent consequences of ethanol toxicity in human hepatocytes.
    Toxicol In Vitro 2017 Apr 3;40:124-133. Epub 2017 Jan 3.
    Department of Pharmaceutical Sciences, University of Perugia, Italy.
    The expression of CYP4F2, a form of cytochrome P-450 with proposed role in α-tocopherol and long-chain fatty acid metabolism, was explored in HepG2 and HepaRG human hepatocytes during ethanol toxicity. Cytotoxicity, ROS production, and JNK and ERK1/2 kinase signaling increased in a dose and time-dependent manner during ethanol treatments; CYP4F2 gene expression decreased, while other CYP4F forms, namely 4F11 and 12, increased along with 3A4 and 2E1 isoforms. α-Tocopherol antagonized the cytotoxicity and CYP4F2 gene repression effect of ethanol in HepG2 cells. Read More

    Development of Orally Administered γ-Tocotrienol (GT3) Nanoemulsion for Radioprotection.
    Int J Mol Sci 2016 Dec 24;18(1). Epub 2016 Dec 24.
    Center for Nanomedicine & Drug Delivery, College of Pharmacy, Xavier University of Louisiana, New Orleans, LA 70125, USA.
    The purpose of this study was two-fold: (1) to formulate γ-tocotrienol (GT3) in a nanoemulsion formulation as a prophylactic orally administered radioprotective agent; and (2) to optimize the storage conditions to preserve the structural integrity of both the formulation and the compound. γ-tocotrienol was incorporated into a nanoemulsion and lyophilized with lactose. Ultra performance liquid chromatography-mass spectroscopy (UPLC-MS) was used to monitor the chemical stability of GT3 over time, the particle size and ζ potential, and scanning electron microscopy (SEM) were used to study the physical stability of the nanoemulsion. Read More

    miRNA-218-loaded carboxymethyl chitosan - Tocopherol nanoparticle to suppress the proliferation of gastrointestinal stromal tumor growth.
    Mater Sci Eng C Mater Biol Appl 2017 Mar 26;72:177-184. Epub 2016 Oct 26.
    State Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200240, PR China. Electronic address:
    Gastrointestinal stromal tumors (GIST) are one of the most common forms of mesenchymal cancers of the gastrointestinal tract. Although chemotherapeutic drugs inhibited the proliferation of GIST, however, sizable proportion of people developed resistance and therefore difficult to treat. In the present study, O-carboxymethyl chitosan (OCMC)-tocopherol polymer conjugate was synthesized and formulated into stable polymeric nanoparticles. Read More

    Bendiocarb induced histopathological and biochemical alterations in rat liver and preventive role of vitamins C and E.
    Environ Toxicol Pharmacol 2017 Jan 27;49:148-155. Epub 2016 Nov 27.
    Gazi University, Faculty of Science, Department of Biology, 06500, Ankara, Turkey.
    In this study, biochemical changes and histological structure of rat liver after bendiocarb administration and possible preventive effects of vitamins C and E were studied. The animals were given with bendiocarb, vitamin C and vitamin E, daily 0,8mg/kg of body weight (bw), 100mg/kg-bw and 100mg/kg-bw for 28days, respectively. Lipid peroxidation, antioxidant enzyme activities, histological alterations and antioxidant capacity assays of liver and also liver function tests and lipid profile were measured. Read More

    Different doses of dexmedetomidine reduce plasma cytokine production, brain oxidative injury, PARP and caspase expression levels but increase liver oxidative toxicity in cerebral ischemia-induced rats.
    Brain Res Bull 2017 Apr 19;130:1-9. Epub 2016 Dec 19.
    Unit of Anesthesiology and Reanimation, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Suleyman Demirel University, Isparta, Turkey.
    Cerebral ischemia-induced progression of brain, liver, and erythrocyte oxidative injuries might be modulated by dexmedetomidine (DEX) as a potent antioxidant and anti-inflammatory drug. The present study was conducted to explore whether two different doses of DEX protect against plasma cytokine and brain, liver and erythrocyte oxidative toxicity and apoptosis in cerebral ischemia-induced rats. Forty-two rats were equally divided into 7 groups. Read More

    Tumor regression after intravenous administration of targeted vesicles entrapping the vitamin E α-tocotrienol.
    J Control Release 2017 Jan 18;246:79-87. Epub 2016 Dec 18.
    Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, United Kingdom. Electronic address:
    The therapeutic potential of tocotrienol, a member of the vitamin E family of compounds with potent in vitro anti-cancer properties, is limited by its inability to specifically reach tumors following intravenous administration. The purpose of this study is to determine whether a novel tumor-targeted vesicular formulation of tocotrienol would suppress the growth of A431 epidermoid carcinoma and B16-F10 melanoma in vitro and in vivo. In this work, we demonstrated that novel transferrin-bearing multilamellar vesicles entrapping α-T3 resulted in a dramatically improved (by at least 52-fold) therapeutic efficacy in vitro on A431 cell line, compared to the free drug. Read More

    Protective effects of levamisole, acetylsalicylic acid, and α-tocopherol against dioxin toxicity measured as the expression of AhR and COX-2 in a chicken embryo model.
    Histochem Cell Biol 2017 Apr 10;147(4):523-536. Epub 2016 Dec 10.
    Laboratory of Neurotoxicology and Environmental Diagnostics, Wroclaw Medical University, Bartla 5, 51-618, Wrocław, Poland.
    Polychlorinated dibenzo-p-dioxins and dibenzofurans (dioxins) are classed as persistent organic pollutants and have adverse effects on multiple functions within the body. Dioxins are known carcinogens, immunotoxins, and teratogens. Dioxins are transformed in vivo, and interactions between the products and the aryl hydrocarbon receptor (AhR) lead to the formation of proinflammatory and toxic metabolites. Read More

    Protective effects of boron and vitamin E on ethylene glycol-induced renal crystal calcium deposition in rat.
    Endocr Regul 2016 Oct;50(4):194-206
    Objectives: Kidney stone disease is a common form of renal disease. Antioxidants, such as vitamin E (Vit E) and boron, are substances that reduce the damage caused by oxidation.

    Methods: Adult male rats were divided into 5 groups (n=6). Read More

    Effectiveness and safety of nutritional supplements in the treatment of hereditary retinal dystrophies: a systematic review.
    Eye (Lond) 2017 Feb 9;31(2):273-285. Epub 2016 Dec 9.
    Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC), Madrid, Spain.
    The hereditary retinal dystrophies (HRDs) are a group of genetically determined disorders that result in loss of the visual function. There is a lack of standard pharmacological treatments or widely accepted nutritional recommendations. The objective of this review is to summarise the scientific evidence on the effectiveness and safety of nutritional supplements for the treatment of HRDs. Read More

    Combined effects of cadmium, temperature and hypoxia-reoxygenation on mitochondrial function in rainbow trout (Oncorhynchus mykiss).
    Aquat Toxicol 2017 Jan 18;182:129-141. Epub 2016 Nov 18.
    Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE C1A 4P3, Canada. Electronic address:
    Although aquatic organisms face multiple environmental stressors that may interact to alter adverse outcomes, our knowledge of stressor-stressor interaction on cellular function is limited. We investigated the combined effects of cadmium (Cd), hypoxia-reoxygenation (H-R) and temperature on mitochondrial function. Liver mitochondria from juvenile rainbow trout were exposed to Cd (0-20μM) and H-R (0 and 5min) at 5, 13 and 25°C followed by measurements of mitochondrial Cd load, volume, complex І active (A)↔deactive (D) transition, membrane potential, ROS release and ultrastructural changes. Read More

    The Vitamin E Analog Gamma-Tocotrienol (GT3) and Statins Synergistically Up-Regulate Endothelial Thrombomodulin (TM).
    Int J Mol Sci 2016 Nov 18;17(11). Epub 2016 Nov 18.
    Division of Radiation Health, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
    Statins; a class of routinely prescribed cholesterol-lowering drugs; inhibit 3-hydroxy-3-methylglutaryl-coenzymeA reductase (HMGCR) and strongly induce endothelial thrombomodulin (TM); which is known to have anti-inflammatory; anti-coagulation; anti-oxidant; and radioprotective properties. However; high-dose toxicity limits the clinical use of statins. The vitamin E family member gamma-tocotrienol (GT3) also suppresses HMGCR activity and induces TM expression without causing significant adverse side effects; even at high concentrations. Read More

    Reduced cytotoxicity in PCB-exposed Chinese Hamster Ovary (CHO) cells pretreated with vitamin E.
    Food Chem Toxicol 2017 Jan 16;99:17-23. Epub 2016 Nov 16.
    Laboratory for Toxicology, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierotti St. 6, 10000 Zagreb, Croatia. Electronic address:
    The aim of this study was to evaluate protective effects of vitamin E (50 -150 μM) in ovary cells upon cytotoxic effects induced by two structurally distinct PCB congeners - planar "dioxin-like" PCB 77 and non-planar di-ortho-substituted PCB 153 with an emphasis on identifying differences in the mechanism of vitamin E action depending on the structure of congeners. Application of three bioassays confirmed that PCBs decrease ovarian cell proliferation with slightly profound effects of PCB 77. PCB - induced ROS production and lipid peroxidation were significant for both congeners with also more noticeable effect for PCB 77. Read More

    The effect of dual-functional hyaluronic acid-vitamin E succinate micelles on targeting delivery of doxorubicin.
    Int J Nanomedicine 2016;11:5851-5870. Epub 2016 Nov 7.
    Modern Research Center for Traditional Chinese Medicine.
    Tumor-targeted delivery system has been developed as an attractive strategy for effective tumor therapy. In this study, in order to enhance the antitumor effects of doxorubicin (DOX), amphiphilic hyaluronic acid (HA)-conjugated vitamin E succinate (VES) copolymers (HA-VES) with different degrees of substitution (DS) were prepared with synergistic antitumor effects and active targeting activities, and utilized as nanocarriers for the efficient delivery of DOX. DOX-loaded HA-VES polymeric micelles (HA-VES/DOX) self-assembled from dual-functional HA-VES copolymer and exhibited excellent loading efficiency and superior colloidal stability. Read More

    In vitro toxicity of pirimiphos-methyl in Atlantic salmon hepatocytes.
    Toxicol In Vitro 2017 Mar 12;39:1-14. Epub 2016 Nov 12.
    National Institute of Nutrition and Seafood Research, Bergen, Norway.
    Recent screening of Atlantic salmon feeds has uncovered residues of several pesticides, including pirimiphos-methyl. Pirimiphos-methyl is an organophosphate (OP) insecticide, causing inhibition of acetylcholinesterase in target organisms. The aim of this study was to examine pirimiphos-methyl non-targeted mode of action toxicity in Atlantic salmon using in vitro exposure. Read More

    Antioxidant and anti-inflammatory effects of Nasturtium officinale involved in attenuation of gentamicin-induced nephrotoxicity.
    Toxicol Mech Methods 2017 Feb 23;27(2):107-114. Epub 2016 Nov 23.
    b Department of Toxicology and Pharmacology, Faculty of Pharmacy , Mazandaran University of Medical Sciences , Sari , Iran.
    Background And Purpose: Gentamicin (GM) is used against bacterial infections. The aim of our investigation was to evaluate the role of inflammation and also oxidative damage in nephrotoxic potential of GM and protective effects of Nasturtium officinale (watercress) against GM-induced nephrotoxicity in Wistar rats.

    Material And Methods: The animals were divided into eight groups: control, solvent, GM (80 mg/kg IP), GM with three doses (50, 100 and 200 mg/kg/d) of hydroalcoholic extract of watercress and one group only received high dose of extract and a group which received GM plus vitamin E for 10 consecutive days. Read More

    Ameliorative potential of α-tocopherol against flubendiamide and copper-induced testicular-insult in Wistar rats.
    Chem Biol Interact 2016 Dec 4;260:91-101. Epub 2016 Nov 4.
    Department of Veterinary Physiology, College of Veterinary Science and Animal Husbandry, U.P. Pt. Deen Dayal Upadhyay Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan (DUVASU), Mathura, 281001, India.
    Study was undertaken to evaluate ameliorative potential of α-tocopherol against copper sulphate and flubendiamide alone and in combination-induced toxicity in rats following 90 days exposure. Absolute and relative organ weights did not differ between treatments groups. Increase of LPO in copper and flubendiamide intoxicated rats but modest increase in copper + flubendiamide group. Read More

    Evaluation of Some Biochemical Parameters and Brain Oxidative Stress in Experimental Rats Exposed Chronically to Silver Nitrate and the Protective Role of Vitamin E and Selenium.
    Toxicol Res 2016 Oct 30;32(4):301-309. Epub 2016 Oct 30.
    Laboratory of Applied Biochemistry and Microbiology, Department of Biochemistry, Science faculty, Badji Mokhtar University, BP 12 Sidi Amar, Annaba, Algeria.
    Due to undesirable hazardous interactions with biological systems, this investigation was undertaken to evaluate the effect of chronic exposure to silver on certain biochemical and some oxidative stress parameters with histopathological examination of brain, as well as the possible protective role of selenium and/or vitamin E as nutritional supplements. Thirty six male rats were divided into six groups of six each: the first group used as a control group. Group II given both vitamin E (400 mg/kg) of diet and selenium (Se) (1 mg/L) in their drinking water. Read More

    Vitamin E: Emerging aspects and new directions.
    Free Radic Biol Med 2017 Jan 2;102:16-36. Epub 2016 Nov 2.
    Department of Biochemistry, Faculty of Medicine, Genetic and Metabolic Diseases Research Center (GEMHAM), Marmara University, 34854 Maltepe, Istanbul, Turkey. Electronic address:
    The discovery of vitamin E will have its 100th anniversary in 2022, but we still have more questions than answers regarding the biological functions and the essentiality of vitamin E for human health. Discovered as a factor essential for rat fertility and soon after characterized for its properties of fat-soluble antioxidant, vitamin E was identified to have signaling and gene regulation effects in the 1980s. In the same years the cytochrome P-450 dependent metabolism of vitamin E was characterized and a first series of studies on short-chain carboxyethyl metabolites in the 1990s paved the way to the hypothesis of a biological role for this metabolism alternative to vitamin E catabolism. Read More

    Melissa of cinalis and Vitamin E as the Potential Therapeutic Candidates for Reproductive Toxicity Caused by Anti-cancer Drug, Cisplatin, in Male Rats.
    Recent Pat Anticancer Drug Discov 2017 ;12(1):73-80
    Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
    Background: High doses of Cisplatin (CP) can disrupt the normal functioning of various tissues such as ovaries and testis. In almost all the patients, spermiotoxicity of CP causes temporary or permanent azoospermia.

    Objective: In this study, the defensive effect of Melissa of cinalis and vitamin E against testicular injuries caused by CP in male rats was evaluated. Read More

    Protection against arsenic-induced hematological and hepatic anomalies by supplementation of vitamin C and vitamin E in adult male rats.
    J Basic Clin Physiol Pharmacol 2016 Nov;27(6):643-652
    Background: Chronic arsenic exposure via contaminated drinking water is a global environmental health problem associated with hematological, hepatic and many serious systemic disorders. This study on adult male rats evaluated the protective effects of vitamin E (VE) and vitamin C (VC) against arsenic-mediated hematological and hepatic toxicities.

    Methods: Arsenic was administered orally as arsenic trioxide (3 mg/kg body weight/day), as a single dose for 30 consecutive days or along with VC/ascorbic acid (200 mg/kg body weight/day dissolved in water) and VE/α-tocopherol (400 mg/kg body weight/day dissolved in olive oil) as supplements. Read More

    Effects of nicotine in the presence and absence of vitamin E on morphology, viability and osteogenic gene expression in MG-63 osteoblast-like cells.
    J Basic Clin Physiol Pharmacol 2016 Nov;27(6):595-602
    Background: Evidence shows that oxidative stress induced by nicotine plays an important role in bone loss. Vitamin E with its antioxidative properties may be able to reverse the effects of nicotine on bone. This study aimed to assess the effects of nicotine in the presence and absence of vitamin E on morphology, viability and osteogenic gene expression in MG-63 (osteosarcoma) human osteoblast-like cells. Read More

    Mixtures of herbicides and metals affect the redox system of honey bees.
    Chemosphere 2017 Feb 22;168:163-170. Epub 2016 Oct 22.
    Département des Sciences Biologiques, Centre TOXEN, Université du Québec à Montréal, Montréal, Québec, Canada.
    The increasing loss of bee colonies in many countries has prompted a surge of studies on the factors affecting bee health. In North America, main crops such as maize and soybean are cultivated with extensive use of pesticides that may affect non-target organisms such as bees. Also, biosolids, used as a soil amendment, represent additional sources of metals in agroecosystems; however, there is no information about how these metals could affect the bees. Read More

    1 OF 73