Therapeutic supermolecular micelles of vitamin E succinate-grafted ε-polylysine as potential carriers for curcumin: Enhancing tumour penetration and improving therapeutic effect on glioma.
- He-Lin Xu,
- Zi-Liang Fan,
- De-Li ZhuGe,
- Bi-Xin Shen,
- Bing-Hui Jin,
- Jian Xiao,
- Cui-Tao Lu,
- Ying-Zheng Zhao
Colloids Surf B Biointerfaces 2017 Jul 12;158:295-307. Epub 2017 Jul 12.
Department of Pharmaceutics, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou City, Zhejiang Province 325035, China; The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou City, Zhejiang Province 325035, China. Electronic address:
Severe toxicity and poor tumour penetration are two intrinsic limited factors to hinder the broad clinical application for most of first-line chemotherapeutics. In this study, a novel vitamin E succinate-grafted ε-polylysine (VES-g-PLL) polymer was synthesized by using ε-polylysine as backbone. By adjusting VES graft ratio, VES-g-PLL (50) with a theoretic VES graft ratio of 50% could self-assemble into a supermolecular micelle with a hydrodynamic diameter (Dh) of ca. Read More