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    3725 results match your criteria Vitamin E Toxicity

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    Renoprotective effect ofagainst cisplatin-induced nephrotoxicity and oxidative stress in rat.
    Saudi J Kidney Dis Transpl 2018 Jan-Feb;29(1):19-29
    Department of Physiology, School of Medicine, Mashhad University of Medical Sciences; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
    Cisplatin is one of the important antineoplastic drugs. Its clinical use has been restricted due to severe kidney toxicity. Nigella sativa (N. Read More

    Antioxidant capacity of omega-3-fatty acids and vitamin E against imidacloprid-induced hepatotoxicity in Japanese quails.
    Environ Sci Pollut Res Int 2018 Feb 13. Epub 2018 Feb 13.
    Department of Pharmacology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, 41522, Egypt.
    Imidacloprid (IM) is a neonicotinoid insecticide, used in a wide range of agricultural activities worldwide. However, it results in ecosystem disturbances and signs of toxicity in human and animals. The current study was designed to elucidate the protective effects of omega-3-fatty acids (OFAs) and vitamin E (Vit E) against IM hepatotoxicity in Japanese quails. Read More

    Protective effects of rosuvastatin and vitamin E against fipronil-mediated oxidative damage and apoptosis in rat liver and kidney.
    Food Chem Toxicol 2018 Feb 9;114:69-77. Epub 2018 Feb 9.
    Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Toukh 13736, Egypt.
    Fipronil (FPN) is a phenylpyrazole insecticide that is extensively used in agriculture and veterinary applications. However, FPN is also a potent environmental toxicant to animals and humans. Therefore, the current study aimed to investigate the protective role of rosuvastatin (ROSU) and vitamin E (Vit E) against FPN-induced hepatorenal toxicity in albino rats. Read More

    Vitamins E and C Prevent DNA Double-strand Breaks in Peripheral Lymphocytes Exposed to Radiations from Iodine-131.
    Indian J Nucl Med 2018 Jan-Mar;33(1):20-24
    Department of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan, Iran.
    Purpose: Iodine-131 is used as a radiopharmaceutical to treat thyroid cancer. The current study aimed to evaluate the effects of vitamins E and C on the level of DNA double-strand breaks (DSBs) caused by Radioiodine-131 (I-131) in human lymphocytes.

    Materials And Methods: Whole blood samples from human volunteers were incubated with a certain concentration of vitamins. Read More

    Vitamin E-Mediated Modulation of Glutamate Receptor Expression in an Oxidative Stress Model of Neural Cells Derived from Embryonic Stem Cell Cultures.
    Evid Based Complement Alternat Med 2017 20;2017:6048936. Epub 2017 Nov 20.
    Department of Nutrition and Dietetics, Faculty of Medicine and Health Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
    Glutamate is the primary excitatory neurotransmitter in the central nervous system. Excessive concentrations of glutamate in the brain can be excitotoxic and cause oxidative stress, which is associated with Alzheimer's disease. In the present study, the effects of vitamin E in the form of tocotrienol-rich fraction (TRF) and alpha-tocopherol (-TCP) in modulating the glutamate receptor and neuron injury markers in anmodel of oxidative stress in neural-derived embryonic stem (ES) cell cultures were elucidated. Read More

    Ferric reducing ability of plasma and assessment of selected plasma antioxidants in adults with celiac disease.
    Folia Med Cracov 2017 ;57(4):13-26
    Unit for Clinical Dietetics, Department of Gastroenterology, Hepatology and Infectious Diseases, Jagiellonian University Medical College, Śniadeckich 5, Kraków, Poland.
    Introduction: Oxidative stress with an excessive free radical production and a reduction in the activity of protective antioxidants is considered as one of the mechanisms responsible for gluten toxicity. However, its role in celiac disease (CD) is unclear.

    Objectives: Evaluation of plasma nonenzymatic antioxidant capacity in patients with CD (both untreated patients and those receiving gluten-free diet [GFD]) by measuring the ferric reducing ability of plasma (FRAP) as well as assessing selected plasma antioxidants. Read More

    Anti-proliferative activity of biochanin A in human osteosarcoma cells via mitochondrial-involved apoptosis.
    Food Chem Toxicol 2018 Feb 3;112:194-204. Epub 2018 Jan 3.
    Department of Medical Laboratory Science and Biotechnology, School of Medicine and Health Sciences, Fooyin University, Kaohsiung, Taiwan; Department of Pharmacy, Fooyin University Hospital, Pingtung, Taiwan. Electronic address:
    Biochanin A is a major isoflavone in red clover and a potent chemopreventive agent against cancer. However, the effects of biochanin A on human osteosarcoma cells have never been clarified. This study investigated the anti-proliferative potential of biochanin A in osteosarcoma cells. Read More

    Effect of polyhexamethylene biguanide on rat liver.
    Toxicol Lett 2018 Mar 2;285:94-103. Epub 2018 Jan 2.
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-3135, United States; Havlik-Wall Professor of Oncology, United States. Electronic address:
    Polyhexamethylene biguanide (PHMB), an amphiphilic polymeric biocide, increased liver tumor incidence in male and female rats at 1000 and 1500 mg/L in drinking water, but not at 500 mg/L in previous studies. In another study, PHMB administered in diet at 4000 mg/kg was negative for hepatocellular tumors. The present studies evaluated bioavailability and distribution of PHMB administered in drinking water and diet and possible modes of action (MOA). Read More

    Complete objective response, stable for 5 years, with the Di Bella Method, of multiple-metastatic carcinoma of the breast.
    Neuro Endocrinol Lett 2017 Dec;38(6):401-407
    Di Bella Foundation, Via Guglielmo Marconi 51 Bologna, 40122, Italy.
    Breast cancer is the most common cancer and the leading cause of cancer death among women. Despite all efforts, about 11,939 deaths and 50,000 new diagnoses for breast cancer were estimated among Italian women in 2016. Therefore new approaches are needed to improve the survival and higher remission rates. Read More

    Vitamin E and Lycopene Reduce Coal Burning Fluorosis-induced Spermatogenic Cell Apoptosis via Oxidative Stress-mediated JNK and ERK Signaling Pathways.
    Biosci Rep 2017 Dec 22. Epub 2017 Dec 22.
    Affiliated Hospital of Guizhou Medical University, Guiyang, China
    Although fluoride has been widely used in toothpaste, mouthwash, and drinking water to prevent dental caries, the excessive intake of fluoride can cause fluorosis which is associated with dental, skeletal, and soft tissue fluorosis. Recent evidences have drawn the attention to its adverse effects on male reproductive system that include spermatogenesis defect, sperm count loss, and sperm maturation impairment. Fluoride induces oxidative stress through the activation of mitogen activated protein kinase (MAPK) cascade which can lead to cell apoptosis. Read More

    Influence of age on arsenic-induced behavioral and cholinergic perturbations: Amelioration with zinc and α-tocopherol.
    Hum Exp Toxicol 2018 Mar 23;37(3):295-308. Epub 2017 Mar 23.
    1 Department of Zoology, Sri Venkateswara University, Tirupati, Andhra Pradesh, India.
    This study was planned to determine arsenic (As) (10 mg/kg body weight given through oral gavage) induced behavioral and cholinergic perturbations in three different age groups of rats; young (postnatal day 21), adult (3 months), and aged (18 months) at 7 days post-acute exposure ( n = 6 for each of the four groups of all three age points). Further, we also evaluated the ameliorative effect of essential metal zinc (Zn; 0.02% through drinking water) and an antioxidant, α-tocopherol (vitamin E; 125 mg/kg body weight through oral gavage) against As-induced neurotoxicity. Read More

    In vitro drug release and in vivo safety of vitamin E and cysteamine loaded contact lenses.
    Int J Pharm 2017 Dec 5. Epub 2017 Dec 5.
    Department of Chemical Engineering, University of Florida, Gainesville, FL, 32611, United States. Electronic address:
    Cystinosis is an orphan disease caused by a genetic mutation that leads to deposition of cystine crystals in many organs including cornea. Ophthalmic manifestation of the disease can be treated with hourly instillation of cysteamine eye drops. The hourly eye drop instillation is tedious to the patients leading to poor compliance and additionally, significant degradation of the drug occurs within one week of opening the bottle, which further complicates this delivery approach. Read More

    The Modulation of NMDA and AMPA/Kainate Receptors by Tocotrienol-Rich Fraction and Α-Tocopherol in Glutamate-Induced Injury of Primary Astrocytes.
    Biomedicines 2017 Dec 1;5(4). Epub 2017 Dec 1.
    Department of Nutrition and Dietetics, Faculty of Medicine and Health Science, University Putra Malaysia, Jalan Upm, 43400 Serdang, Malaysia.
    Astrocytes are known as structural and supporting cells in the central nervous system (CNS). Glutamate, as a main excitatory amino acid neurotransmitter in the mammalian central nervous system, can be excitotoxic, playing a key role in many chronic neurodegenerative diseases. The aim of the current study was to elucidate the potential of vitamin E in protecting glutamate-injured primary astrocytes. Read More

    CCL2 is Upregulated by Decreased miR-122 Expression in Iron-Overload-Induced Hepatic Inflammation.
    Cell Physiol Biochem 2017 24;44(3):870-883. Epub 2017 Nov 24.
    Military Hygiene Department, Faculty of Naval Medicine, Second Military Medical University, Shanghai, China.
    Background/aims: Iron overload (IO) is accompanied by hepatic inflammation. The chemokine (C-C motif) ligand 2 (CCL2) mediates inflammation, and its overexpression is associated with IO. However, whether IO results in CCL2 overexpression in the liver and the underlying mechanisms are unclear. Read More

    Placental transfer and levels of mercury, selenium, vitamin E, and docosahexaenoic acid in maternal and umbilical cord blood.
    Environ Int 2018 Feb 15;111:309-315. Epub 2017 Nov 15.
    Department of Environmental Health Sciences, Akita University Graduate School of Medicine, Akita, Japan.
    Methylmercury (MeHg) is a neurotoxicant known to affect the developing fetal brain as a sensitive target organ. As most mercury (Hg) in blood is MeHg, total mercury (THg) levels in blood are used to estimate the body burden of MeHg. The nutrients selenium (Se), vitamin E, and docosahexaenoic acid (DHA) are protective against MeHg toxicity. Read More

    N-acetyl-l-cysteine and Mnattenuate Cd-induced disturbance of the intracellular free calcium homeostasis in cultured cerebellar granule neurons.
    Toxicology 2018 01 31;393:1-8. Epub 2017 Oct 31.
    Research Center of Neurology, Volokolamskoe Shosse 80, 125367, Moscow, Russia.
    Cadmium is a highly toxic heavy metal that is capable of accumulating in the body via direct exposure or through the alimentary and respiratory tract, leading to neurodegeneration. In this article, we show that the application of CdCl(0.001-0. Read More

    Chemoprotective role of ethanol extract of Urtica urens L. against the toxicity of imidacloprid on endocrine disruption and ovarian morphometric in female rats, GC/MS analysis.
    Biomed Pharmacother 2018 Jan 6;97:518-527. Epub 2017 Nov 6.
    Laboratory of Histology Embryology and Reproductive Biology, Faculty of Medicine of Sfax, University of Sfax, Tunisia.
    Imidacloprid (IMI) is a widely used in Tunisia and abroad, and high doses of IMI have been known to cause endocrine disruption. Some reports claim that Urtica urens L. (UU) can reduce toxicity thanks to it anti-inflammatory and antioxidant activities, but there is no scientific evidence justifying its use, which lets us think to its direct effect on the metabolism of the ovarian tissue. Read More

    Nutraceutical Approach to Peripheral Neuropathies: Evidence from Clinical Trials.
    Curr Drug Metab 2017 Oct 31. Epub 2017 Oct 31.
    Medical and Surgical Sciences Department, University of Bologna, Bologna. Italy.
    Peripheral neuropathies are damages to or disorders of the peripheral nervous system including radiculopathies, plexopathies, mono-, multi- and polyneuropathies. The etiopathogenetic mechanisms include genetic, traumatic, toxic, metabolic, infectious, nutritional, inflammatory and paraneoplastic causes. The treatment of peripheral neuropathies should primarily address their contributing causes. Read More

    Effects of turmeric () and vitamin E on histopathological lesions induced in bursa of Fabricius of broiler chicks by salinomycin.
    Vet Res Forum 2017 15;8(3):231-236. Epub 2017 Sep 15.
    DVM Graduated, Faculty of Veterinary Medicine, University of Shiraz, Shiraz, Iran.
    The aim of this study was to evaluate the protective effects of the turmeric in comparison to vitamin E on bursal damages induced by salinomycin in broiler chickens. In this study, forty one day-old broiler chicks were randomly divided into four treatment groups: 1- basal diet as control, 2- basal diet plus salinomycin, 3- basal diet plus salinomycin (SLM) and vitamin E (Vit. E) and 4- basal diet plus salinomycin and turmeric powder. Read More

    Vitamin E (α tocopherol) attenuates toxicity and oxidative stress induced by aflatoxin in rats.
    Adv Clin Exp Med 2017 Sep;26(6):907-917
    Department of Pathology, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey.
    Background: Aflatoxins are toxic metabolites produced by Aspergillus flavus and Aspergillus parasiticus and are classified as group I carcinogens by the International Agency for Research on Cancer (IARC).

    Objectives: The purpose of this study was to investigate the possible preventive role of vitamin E (Vit E) on aflatoxin (AF) induced toxicity by using biochemical and histopathological approaches.

    Material And Methods: Wistar-Albino rats were divided into 4 groups as follows: control group, Vit E group (Vit E was administered), AFB1 group (a single dose of AFB1 was administered), AF + Vit E group (AF and Vit E were administered). Read More

    Nebulized coenzyme Qnanosuspensions: A versatile approach for pulmonary antioxidant therapy.
    Eur J Pharm Sci 2018 Feb 21;113:159-170. Epub 2017 Oct 21.
    Food and Drug Department, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy; Research Center Pharmaceutical Engineering GmbH, Graz, Austria. Electronic address:
    Coenzyme Q(CoQ) is an antioxidant substance indicated as a dietary supplement which has been proposed as adjuvant in the treatment of cardiovascular disorders and cancer for its protective and immunostimulating activities. The aim of this work was the production by high-pressure homogenization, characterization and stability investigation of three different CoQnanosuspensions designed to be administered to the lungs by nebulization. Three surfactants, i. Read More

    The fungal neurotoxin penitrem A induces the production of reactive oxygen species in human neutrophils at submicromolar concentrations.
    Toxicology 2017 12 13;392:64-70. Epub 2017 Oct 13.
    Section of Chemistry and Toxicology, Norwegian Veterinary Institute, P.O. Box 750 Sentrum, N-0106 Oslo, Norway; R&D Section, PET-center, University Hospital of North Norway (UNN), P.O. Box 100 Langnes, N-9038 Tromsø, Norway. Electronic address:
    Penitrem A is a fungal neurotoxin that recurrently causes intoxication in animals, and occasionally also in humans. We have previously reported that penitrem A induced the production of reactive oxygen species (ROS) in rat cerebellar granule cells, opening for a new mechanism of action for the neurotoxin. The aim of this study was to examine the potential of penitrem A to induce ROS production in isolated human neutrophil granulocytes, and to study possible mechanisms involved. Read More

    Vitamin E Reversed Apoptosis of Cardiomyocytes Induced by Exposure to High Dose Formaldehyde During Mice Pregnancy.
    Int Heart J 2017 Oct 30;58(5):769-777. Epub 2017 Sep 30.
    Department of Echocardiography, The Affiliated Hospital of Qingdao University, Qingdao.
    In this study, we investigated the protection effect of Vitamin E (Vit E) on formaldehyde (FA) exposure during pregnancy induced apoptosis of cardiomyocytes, and used an HL-1 cell line to confirmed the findings in vivo.Pregnant mice received different doses of FA (0.5 mg/kg, 1. Read More

    Neuro-endocrine effects of aqueous extract of(Linn.) leaf in male Wistar rat model of cyclophosphamide-induced reproductive toxicity.
    Toxicol Rep 2016 3;3:608-619. Epub 2016 Aug 3.
    Department of Medical Laboratory Sciences, College of Medicine, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria.
    Cyclophosphamide (CP) is a widely used cytotoxic alkylating agent with antitumor and immunosuppressant properties that is associated with various forms of reproductive toxicity. The significance of natural antioxidants of plant origin should be explored, especially in a world with increasing incidence of patients in need of chemotherapy. The neuro-endocrine effects of aqueous extract of(Linn. Read More

    Effectiveness of Amygdalus mongolica oil in hyperlipidemic rats and underlying antioxidant processes.
    J Toxicol Environ Health A 2017 26;80(22):1193-1198. Epub 2017 Sep 26.
    a Department of Pharmacy , Baotou Medical College , Baotou , Inner Mongolia , P.R. China.
    The seeds of Amygdalus mongolica contain various constituents including flavonoids and vitamin E, which are known to exert antioxidant effects. However, the safety of the oil extract of this compound is not fully known. The aim of this study was to determine the physicochemical properties of A. Read More

    The oxidative stress in allelopathy: Participation of prenyllipid antioxidants in the response to juglone in Chlamydomonas reinhardtii.
    Phytochemistry 2017 Dec 22;144:171-179. Epub 2017 Sep 22.
    Department of Plant Physiology and Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387, Kraków, Poland.
    Allelopathy is a phenomenon, where one species releases compounds able to inhibit the growth of other species. Juglone, 5-hydroxy-1,4-naphtoquinone, is an allelochemical produced by walnut trees. The main mode of juglone toxicity is the formation of semiquinone radicals, able to reduce Oto superoxide. Read More

    Changes in hepatic gene expression and serum metabolites after oral administration of overdosed vitamin-E-loaded nanoemulsion in rats.
    Food Chem Toxicol 2017 Nov 18;109(Pt 1):421-427. Epub 2017 Sep 18.
    Department of Foods and Nutrition, Kookmin University, Seoul, South Korea. Electronic address:
    Vitamin-E-loaded nanoemulsion (Vit E-NE) was produced, and the effects of repeated oral administration of Vit E-NE (2 g/kg/day) for five days on hepatic gene expression and serum metabolites were investigated in rats. The mean particle diameter and zeta potential of Vit E-NE was 112 nm and 56 mV, respectively. Vit E-NE administered rats showed significantly higher triglyceride content than of standard diet (control) or Vit E control emulsion (Vit E-CE) group but no toxicity symptoms were found in blood biochemical analysis. Read More

    Time-dependent effects of perfluorinated compounds on viability in cerebellar granule neurons: Dependence on carbon chain length and functional group attached.
    Neurotoxicology 2017 Dec 15;63:70-83. Epub 2017 Sep 15.
    Department of Production Animal Clinical Sciences, NMBU-School of Veterinary Science, P.O. Box 8146 Dep, N-0033, Oslo, Norway.
    The toxicity of long chained perfluoroalkyl acids (PFAAs) has previously been reported to be related to the length of the perfluorinated carbon chain and functional group attached. In the present study, we compared the cytotoxicity of six PFAAs, using primary cultures of rat cerebellar granule neurons (CGNs). Two perfluoroalkyl sulfonic acids (PFSAs, chain length Cand C) and four perfluoroalkyl carboxylic acids (PFCAs, chain length C-C) were studied. Read More

    The role of some feed additives in fish fed on diets contaminated with cadmium.
    Environ Sci Pollut Res Int 2017 Oct 30;24(30):23636-23645. Epub 2017 Aug 30.
    Specialized Hospital, Ain Shams University, Cairo, Egypt.
    The decline of cadmium pollution in fish farms is needed by any adequate method. The present study was designed to explore the effect of dietary cadmium contamination and its amelioration by using dietary clay, probiotic (Bactocell®), vitamin C, and vitamin E supplementation in Nile tilapia fish diet on growth rate, feed efficiency, blood components, and cadmium residues. Fish were separated into 15 groups, each group of fish was stocked into three aquaria and each contains 20 fishes. Read More

    Antioxidant ameliorating effects against HO-induced cytotoxicity in primary endometrial cells.
    Toxicol Mech Methods 2018 Feb 15;28(2):122-129. Epub 2017 Sep 15.
    a Biochemistry Department , Medical School, Shiraz University of Medical Sciences , Shiraz , Iran.
    Oxidative stress and a disrupted antioxidant system are involved in a variety of pregnancy complications. In the present study, the role of vitamin E (Vit E) and folate as radical scavengers on the GSH homeostasis in stress oxidative induced in rat endometrial cells was investigated. Primary endometrial stromal cell cultures treated with 50 and 200 µM of HOand evaluated the cytoprotective effects of Vit E (5 µM) and folate (0. Read More

    Co-delivery nanocarriers targeting folate receptor and encapsulating 2-deoxyglucose and α-tocopheryl succinate enhance anti-tumor effect in vivo.
    Int J Nanomedicine 2017 8;12:5701-5715. Epub 2017 Aug 8.
    State Key Laboratory of Cancer Biology, Department of Pharmacogenomics, School of Pharmacy, The Fourth Military Medical University.
    A combination administration of chemical agents was highlighted to treat tumors. Recently, tumor cell has been found to be different from normal cell in metabolic manner. Most of cancer cells prefer aerobic glycolysis to mitochondrial oxidative phosphorylation (OXPHOS) to satisfy energy and biomass synthesis requirement to survive, grow and proliferate, which provides novel and potential therapeutic targets for chemotherapy. Read More

    UV-vis degradation of α-tocopherol in a model system and in a cosmetic emulsion-Structural elucidation of photoproducts and toxicological consequences.
    J Chromatogr A 2017 Sep 8;1517:126-133. Epub 2017 Aug 8.
    Laboratoire de Chimie Moléculaire, Ecole Polytechnique, UMR-9168, 91128 Palaiseau Cedex, France. Electronic address:
    The UV-vis photodegradation of α-tocopherol was investigated in a model system and in a cosmetic emulsion. Both gas chromatography coupled with tandem mass spectrometry (GC-MS/MS) and high performance liquid chromatography coupled with ultrahigh resolution Fourier transform ion cyclotron resonance mass spectrometry (LC-UHR-MS) were used for photoproducts structural identification. Nine photoproduct families were detected and identified based on their mass spectra and additional experiments with α-tocopherol-d; phototransformation mechanisms were postulated to rationalize their formation under irradiation. Read More

    Redox-responsive PEGylated self-assembled prodrug-nanoparticles formed by single disulfide bond bridge periplocymarin-vitamin E conjugate for liver cancer chemotherapy.
    Drug Deliv 2017 Nov;24(1):1170-1178
    a Department of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering , Jiangsu University , Zhenjiang , People's Republic of China.
    Periplocymarin (PPM), a cardiac glycoside, has a narrow therapeutic index, poor tumor selectivity and severe cardiovascular toxicity which hinder its wide clinical applications in cancer treatment. Herein, we report novel redox-responsive prodrug-nanoparticles (MPSSV-NPs) self-assembled by co-nanoprecipitation of PPM-vitamin E conjugate and a PEG derivative of linoleate (mPEG2000-LA) in water. It was found that the characteristics of PPM-vitamin E nanoparticles (PSSV-NPs) were improved through co-nanoprecipitation with increased percentages of mPEG2000-LA. Read More

    Mitigation of Acute Aluminum Toxicity by Sodium Selenite and N-Acetylcysteine in Adult Male Rats.
    Biol Trace Elem Res 2017 Aug 17. Epub 2017 Aug 17.
    Faculty of Science, Department of Zoology, University of Ain Shams, Abbassia, Cairo, 11566, Egypt.
    The objective of this study is to investigate the toxic effects of aluminum and the potential alleviation of selenite and N-acetylcysteine (NAC) on this toxicity. Acute aluminum toxicity was induced by intraperitoneal (i.p. Read More

    Therapeutic supermolecular micelles of vitamin E succinate-grafted ε-polylysine as potential carriers for curcumin: Enhancing tumour penetration and improving therapeutic effect on glioma.
    Colloids Surf B Biointerfaces 2017 Oct 12;158:295-307. Epub 2017 Jul 12.
    Department of Pharmaceutics, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou City, Zhejiang Province 325035, China; The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou City, Zhejiang Province 325035, China. Electronic address:
    Severe toxicity and poor tumour penetration are two intrinsic limited factors to hinder the broad clinical application for most of first-line chemotherapeutics. In this study, a novel vitamin E succinate-grafted ε-polylysine (VES-g-PLL) polymer was synthesized by using ε-polylysine as backbone. By adjusting VES graft ratio, VES-g-PLL (50) with a theoretic VES graft ratio of 50% could self-assemble into a supermolecular micelle with a hydrodynamic diameter (D) of ca. Read More

    The protective role of vitamin E on Oreochromis niloticus exposed to ZnONP.
    Ecotoxicol Environ Saf 2017 Nov 6;145:1-7. Epub 2017 Jul 6.
    Young Researchers and Elite Club, Science and Research Branch, Islamic Azad University, Tehran, Iran.
    The present study evaluated if ZnONPs induce oxidative stress, immunological impairment and cellular damage in tilapia (Oreochromis niloticus), as well as the possible protective effect of vitamin E. Fish were fed for ten days and five study groups were investigated: controls, two ZnONPs concentrations (1.5 and 2. Read More

    Protective effects of Vitamin E on CCl-induced testicular toxicity in male rats.
    Physiol Int 2016 Jun;103(2):157-168
    Department of Zoology, Faculty of Science, Alexandria University , Alexandria, Egypt.
    The increased generation of free radicals plays an important role in testicular damage. The present study aimed to investigate the adverse effects of carbon tetrachloride (CCl) on the reproductive system of male rats as well as to examine whether Vitamin E (VE) is able to ameliorate these effects. The rats were equally divided into three groups: control, CCl-treated, and CCl + VE-treated groups. Read More

    Chemical components, antioxidant potential and hepatoprotective effects of Artemisia campestris essential oil against deltamethrin-induced genotoxicity and oxidative damage in rats.
    Gen Physiol Biophys 2017 Jul;36(3):331-342
    Laboratory of Animal Ecophysiology, Sciences Faculty, University of Sfax, Sfax, Tunisia.
    In the present study, we evaluated the antioxidant potential of Artemisia campestris essential oil (ACEO) and the possible protective effects against deltamethrin induced hepatic toxic effects. The ACEO showed radical scavenging activity with IC50 = 47.66 ± 2. Read More

    Vitamin E as a novel therapy in the treatment of acute aluminum phosphide poisoning.
    Turk J Med Sci 2017 Jun 12;47(3):795-800. Epub 2017 Jun 12.
    Toxicological Research Center, Excellent Center of Clinical Toxicology, Department of Clinical Toxicology, Loghman Hakim Hospital Poison Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Background/aim: Aluminum phosphide (AlP) is commonly used as a fumigant in developing countries. Induction of oxidative stress is one of the most important mechanisms of its toxicity. In this regard, and considering that there is no specific antidote for its treatment, the aim of this study was to evaluate the effect of vitamin E in the treatment of acute AlP poisoning. Read More

    Targeting integrin-rich tumors with temoporfin-loaded vitamin-E-succinate-grafted chitosan oligosaccharide/d-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles to enhance photodynamic therapy efficiency.
    Int J Pharm 2017 Aug 9;528(1-2):287-298. Epub 2017 Jun 9.
    Department of Pharmaceutics, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China; Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 200237, China. Electronic address:
    A major challenge in cancer photodynamic therapy (PDT) is the poor tumor selectivity of the photosensitizer. Therefore, temoporfin (mTHPC)-loaded nanoparticles, based on vitamin-E-succinate-grafted chitosan oligosaccharide and cyclic (arginine-glycine-aspartic acid-d-phenylalanine-lysine) (c[RGDfK])-modified d-α-tocopheryl polyethylene glycol 1000 succinate, were prepared (RGD-NPs) and were expected to enhance the accumulation of mTHPC in integrin-rich U87MG tumors. The RGD-NPs generated were 144. Read More

    Evolution of New "Bolaliposomes" using Novel α-Tocopheryl Succinate Based Cationic Lipid and 1,12-Disubstituted Dodecane-Based Bolaamphiphile for Efficient Gene Delivery.
    Bioconjug Chem 2017 07 27;28(7):1965-1977. Epub 2017 Jun 27.
    National Institute of Technology , Warangal 506004, Telangana, India.
    Nonviral lipid-based vectors are promising transporting systems for the intracellular delivery of therapeutic gene sequences and directly influence the success of gene delivery. However, the associated drawbacks like lower transfection, toxicity, and targetability require further improvement. Thus, herein, we report a novel lipid formulation by the mixing of two distinct cationic surfactants such as tocopheryl succinate based cationic lipid and 1,12 dodecane based bolaamphiphile and prove it to be a good transfection reagent with its competing potential with the "golden standard", Lipofectamine 3000 (L3K). Read More

    Emamectin benzoate induces ROS-mediated DNA damage and apoptosis in Trichoplusia Tn5B1-4 cells.
    Chem Biol Interact 2017 Aug 7;273:90-98. Epub 2017 Jun 7.
    Shanghai Key Lab of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China. Electronic address:
    Emamectin benzoate (EMB), a novel macrocyclic lactone insecticide, possesses high efficacy and beneficial selective toxicity in agriculture, but so far the EMB-induced cytotoxic action in arthropod insect remains unclear. The present studies were carried out to characterize the property of EMB on the induction of reactive oxygen species (ROS)-mediated DNA damage and apoptosis in Trichoplusia Tn5B1-4 cell model. Following the exposure to EMB at 2. Read More

    Ovarian Damages Produced by Aerosolized Fine Particulate Matter (PM) Pollution in Mice: Possible Protective Medications and Mechanisms.
    Chin Med J (Engl) 2017 Jun;130(12):1400-1410
    Department of Clinical Medicine, Weifang Medical University, Weifang, Shandong 261000; Department of Obstetrics and Gynecology, Aviation General Hospital of China Medical University and Beijing Institute of Translational Medicine, Chinese Academy of Sciences, Beijing 100012, China.
    Background: Ambient aerosol fine particulate matter (PM2.5) is associated with male reproductive toxicity in experiments and may have adverse effects in the female. However, studies evaluating the protective effects and precise mechanisms of aspirin, Vitamin C, Vitamin E, or ozone against toxic effects of PM2. Read More

    Valorization of Dacryodes rostrata fruit through the characterization of its oil.
    Food Chem 2017 Nov 5;235:257-264. Epub 2017 May 5.
    School of Engineering, Advanced Engineering Platform, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway, Selangor, Malaysia.
    Dacryodes rostrata (kembayau) is an important food and oil resource for local communities in Borneo, but it is not commonly known to wider community. The objective of this work is to valorize kembayau fruit by evaluating the characteristics of the oil from the fruit. In this study, the physicochemical characteristics and the lipophilic essential nutrient; the fatty acid composition, vitamin E and beta-carotene content of oils obtained from the peel, pulp and seeds of kembayau fruits were studied. Read More

    Enhancement of apoptotic activities on brain cancer cells via the combination of γ-tocotrienol and jerantinine A.
    Phytomedicine 2017 Jul 10;30:74-84. Epub 2017 Mar 10.
    School of Biosciences, Faculty of Science, The University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor, Malaysia; Biotechnology Research Centre, The University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor, Malaysia. Electronic address:
    Background: γ-Tocotrienol, a vitamin E isomer possesses pronounced in vitro anticancer activities. However, the in vivo potency has been limited by hardly achievable therapeutic levels owing to inefficient high-dose oral delivery which leads to subsequent metabolic degradation. Jerantinine A, an Aspidosperma alkaloid, originally isolated from Tabernaemontana corymbosa, has proved to possess interesting anticancer activities. Read More

    Potential Use of Chemoprotectants against the Toxic Effects of Cyanotoxins: A Review.
    Toxins (Basel) 2017 May 23;9(6). Epub 2017 May 23.
    Area of Toxicology, Faculty of Pharmacy, Universidad de Sevilla, Sevilla 41012, Spain.
    Cyanobacterial toxins, particularly microcystins (MCs) and cylindrospermopsin (CYN), are responsible for toxic effects in humans and wildlife. In order to counteract or prevent their toxicity, various strategies have been followed, such as the potential application of chemoprotectants. A review of the main substances evaluated for this aim, as well as the doses and their influence on cyanotoxin-induced toxicity, has been performed. Read More

    Protective effects of vitamin E against reproductive toxicity induced by di(2-ethylhexyl) phthalate via PPAR-dependent mechanisms.
    Toxicol Mech Methods 2017 Sep 8;27(7):551-559. Epub 2017 Jun 8.
    a Department of Urology , Children's Hospital of Chongqing Medical University , Chongqing , China.
    Objective: To investigate the protective/ameliorative effects of vitamin E on di-2-(ethylhexyl) phthalate (DEHP)-induced reproductive toxicity, particularly in testicular toxicity in male rats, emphasizing peroxisome proliferator-activated receptor (PPAR)-dependent mechanism.

    Methods: Sprague-Dawley females were exposed by oral route to DEHP alone or associated with vitamin E from gestation day (GD) 12.5 to postnatal day (PND) 3 according to the following treatment regimens: vehicle control (corn oil), vitamin E (200 mg/kg)+corn oil, DEHP (500 mg/kg)+corn oil, and DEHP (500 mg/kg)+vitamin E (200 mg/kg)+corn oil. Read More

    Protective effect of ethanolic extract of Urtica urens L. against the toxicity of imidacloprid on bone remodeling in rats and antioxidant activities.
    Biomed Pharmacother 2017 Jul 16;91:1022-1041. Epub 2017 May 16.
    Research Unit of Histo-Embryology and Cytogenetic, Medicine Faculty, University of Sfax, 3029 Sfax, Tunisia.
    Imidacloprid (IMI) is very harmful to human health and cause problems. Recently, plants have been considered as potential agents for protection against these disorders. Urtica urens L. Read More

    Synergistic protective effect of FTY720 and vitamin E against simulated cerebral ischemia in vitro.
    Mol Med Rep 2017 Jul 11;16(1):396-402. Epub 2017 May 11.
    Key Laboratory for Corneal Tissue Engineering, College of Marine Life Sciences, Ocean University of China, Qingdao, Shandong 266003, P.R. China.
    The purpose of the present study was to explore the combination effect of FTY720 and vitamin E on cerebral ischemia. Astrocytes were isolated from newborn Sprague‑Dawley rats and were subjected to FTY720, vitamin E, or combination of the two. The astrocyte cultures were then exposed to oxygen‑glucose deprivation (OGD) to simulate an ischemic model in vitro. Read More

    Alterations in serum levels of selected markers of oxidative imbalance in adult celiac patients with extraintestinal manifestations: a pilot study.
    Pol Arch Intern Med 2017 Aug 5;127(7-8):532-539. Epub 2017 May 5.
    INTRODUCTION    Oxidative stress is considered to be one of the mechanisms responsible for gluten toxicity, but its role in celiac disease (CD) remains unclear. OBJECTIVES    The aim of the study was to evaluate oxidative imbalance in the pathomechanism of CD by determining the concentrations of nitric oxide (NO) and selected antioxidant parameters. PATIENTS AND METHODS    The study involved 197 adult patients: 53 patients with untreated active CD, 92 celiac patients on gluten‑free diet (GFD), and 52 controls. Read More

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