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    3873 results match your criteria Vitamin E Deficiency

    1 OF 78

    The dietary protein paradox and threonine (15) N-depletion: Pyridoxal-5'-phosphate enzyme activity as a mechanism for the δ(15) N trophic level effect.
    Rapid Commun Mass Spectrom 2017 Feb 9. Epub 2017 Feb 9.
    Department of Physiology of Energy Metabolism, German Institute of Human Nutrition in Potsdam-Rehbruecke (DIfE), Arthur-Scheunert-Allee 114-116, Nuthetal, D-14558, Germany.
    Rationale: Nitrogen stable isotope ratios (δ(15) N values) are used to reconstruct dietary patterns, but the biochemical mechanism(s) responsible for the diet to tissue trophic level effect and its variability are not fully understood. Here δ(15) N amino acid (AA) values and physiological measurements (nitrogen intake, plasma albumin concentrations, liver reduced glutathione concentrations and leucine oxidation rates) are used to investigate increased dietary protein consumption and oxidative stress (vitamin E deficiency) in rat total plasma protein.

    Methods: Using gas chromatography-combustion-isotope ratio mass spectrometry, the δ(15) N values from N-pivaloyl-i-propyl esters of 15 AAs are reported for rats (n = 40) fed casein-based diets with: adequate protein (AP, 13. Read More

    Liver Transplantation as a Treatment for Severe Refractory Vitamin E Deficiency Related to Progressive Familial Intrahepatic Cholestasis Type 2 in a Pediatric Patient.
    ACG Case Rep J 2016 Aug 21;3(4):e193. Epub 2016 Dec 21.
    Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic Children's Hospital, Cleveland, OH.
    Refractory vitamin E deficiency is thought to have irreversible effects on neurologic function. We report an adolescent boy with severe refractory vitamin E deficiency due to progressive familial intrahepatic cholestasis (PFIC) type 2. His consequent neurologic dysfunction included severe ataxia, dysmetria, dysarthria, and cranial nerve VI palsy. Read More

    Lethal dysregulation of energy metabolism during embryonic vitamin E deficiency.
    Free Radic Biol Med 2017 Jan 14;104:324-332. Epub 2017 Jan 14.
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA; College of Public Health and Human Sciences, Oregon State University, Corvallis, OR 97331, USA; Environmental Health Sciences Center, Oregon State University, Corvallis, OR 97331, USA. Electronic address:
    Vitamin E (α-tocopherol, VitE) was discovered in 1922 for its role in preventing embryonic mortality. We investigated the underlying mechanisms causing lethality using targeted metabolomics analyses of zebrafish VitE-deficient embryos over five days of development, which coincided with their increased morbidity and mortality. VitE deficiency resulted in peroxidation of docosahexaenoic acid (DHA), depleting DHA-containing phospholipids, especially phosphatidylcholine, which also caused choline depletion. Read More

    Synthesis, characterization, and in-vitro antitumor activity of the polyethylene glycol (350 and 1000) succinate derivatives of the tocopherol and tocotrienol isomers of Vitamin E.
    Int J Pharm 2017 Jan 16;519(1-2):145-156. Epub 2017 Jan 16.
    College of Health and Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA, USA; College of Pharmacy, Taipei Medical University, Taipei, Taiwan. Electronic address:
    Vitamin E refers to a group of saturated tocopherol (T) isomers and the biologically more active unsaturated tocotrienol (T3) isomers. PEGylated α-tocopherol, commercially known as Vitamin E TPGS, has been used as an emulsifier and therapeutic agent for children with vitamin E deficiency. Limited information, however, is available about the PEG conjugates of the tocotrienol isomers of vitamin E. Read More

    Analysis of the concentration of vitamin E in erythrocytes of patients with celiac disease.
    Prz Gastroenterol 2016 20;11(4):282-285. Epub 2016 Jul 20.
    Department of Paediatrics, Institute of Mother and Child, Warsaw, Poland.
    Introduction: Consumption of gluten proteins leads to an enteropathy characterised by lymphocytic infiltration of mucous membrane, crypts hypertrophy, and atrophy of villi. Enteropathy leads to disturbances in the immune system as well as secondary deficiency of vitamin E.

    Aim: Analysis of the concentration of vitamin E in erythrocytes of patients with celiac disease. Read More

    Relationship between deficiencies in vitamin A and E and occurrence of infectious diseases among children.
    Eur Rev Med Pharmacol Sci 2016 Dec;20(23):5009-5012
    Department of Pediatrics, Daqing Longnan Hospital, Daqing, Heilongjiang, China.
    Objective: To investigate the relationship between vitamin A deficiency (VAD), vitamin E deficiency (VED) and infectious diseases.

    Patients And Methods: We chose 684 cases of healthy children age 5 months-12 years from our hospital, measured their VA, VE from vein under the light proof condition with high-pressure liquid chromatography. Thereafter, the children who get the acute respiratory tract infection (ARI) or diarrhea two weeks later were registered. Read More

    Effects of dietary vitamin E deficiency on systematic pathological changes and oxidative stress in fish.
    Oncotarget 2016 Dec;7(51):83869-83879
    Department of Aquaculture, Sichuan Agricultural University, Chengdu, Sichuan, China.
    The aim of this study was to investigate the effects of dietary vitamin E deficiency on systematic pathological changes and oxidative stress in fish. A total of 320 healthy common carp (Cyprinus carpio) were randomized into four groups; the control group was fed a basal diet supplemented with 100 IUkg-1 of vitamin E, while the three experimental groups were fed the same basal diet with reduced vitamin E content (0, 25, or 50 IUkg-1). Findings showed that fish in the experimental groups mainly presented with sekoke disease, exophthalmia, leprnorthsis, and ascites. Read More

    Vitamin E deficiency depressed fish growth, disease resistance, and the immunity and structural integrity of immune organs in grass carp (Ctenopharyngodon idella): Referring to NF-κB, TOR and Nrf2 signaling.
    Fish Shellfish Immunol 2017 Jan 22;60:219-236. Epub 2016 Nov 22.
    Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Chengdu 611130, China. Electronic address:
    This study investigated the effects of dietary vitamin E on growth, disease resistance and the immunity and structural integrity of head kidney, spleen and skin in grass carp (Ctenopharyngodon idella). The fish were fed six diets containing graded levels of vitamin E (0, 45, 90, 135, 180 and 225 mg/kg diet) for 10 weeks. Subsequently, a challenge test was conducted by injection of Aeromonas hydrophila. Read More

    Transcriptome profiling of equine vitamin E deficient neuroaxonal dystrophy identifies upregulation of liver X receptor target genes.
    Free Radic Biol Med 2016 Dec 15;101:261-271. Epub 2016 Oct 15.
    Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, United States.
    Specific spontaneous heritable neurodegenerative diseases have been associated with lower serum and cerebrospinal fluid α-tocopherol (α-TOH) concentrations. Equine neuroaxonal dystrophy (eNAD) has similar histologic lesions to human ataxia with vitamin E deficiency caused by mutations in the α-TOH transfer protein gene (TTPA). Mutations in TTPA are not present with eNAD and the molecular basis remains unknown. Read More

    Minimum Selenium Requirements Increase When Repleting Second-Generation Selenium-Deficient Rats but Are Not Further Altered by Vitamin E Deficiency.
    Biol Trace Elem Res 2016 Oct 17. Epub 2016 Oct 17.
    Department of Nutritional Sciences, University of Wisconsin, 1415 Linden Drive, Madison, WI, 53706, USA.
    Second-generation selenium-deficient weanling rats fed graded levels of dietary Se were used (a) to study the impact of initial Se deficiency on dietary Se requirements; (b) to determine if further decreases in selenoperoxidase expression, especially glutathione peroxidase 4 (Gpx4), affect growth or gross disease; and (c) to examine the impact of vitamin E deficiency on biochemical and molecular biomarkers of Se status. Rats were fed a vitamin E-deficient and Se-deficient crystalline amino acid diet (3 ng Se/g diet) or that diet supplemented with 100 μg/g all-rac-α-tocopheryl acetate and/or 0, 0.02, 0. Read More

    Probucol dramatically enhances dihydroartemisinin effect in murine malaria.
    Malar J 2016 Sep 15;15:472. Epub 2016 Sep 15.
    Research Unit for Functional Genomics, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro City, Hokkaido, Japan.
    Background: Artemisinin-based combination therapy (ACT) has been adopted as national policy for the first-line treatment in large number of malaria-endemic regions. However, artemisinin-resistant parasites have emerged and are spreading, with slow-cleaning parasites being reported in patients treated with ACT. It means that more parasites are exposed to the partner drug alone and the risk of developing resistant parasites against the partner drug is increasing. Read More

    Lower Plasma Levels of Antioxidant Vitamins in Patients with Metabolic Syndrome: A Case Control Study.
    Adv Clin Exp Med 2016 Jul-Aug;25(4):689-700
    Department of Internal and Infectious Diseases, Medical University of Lodz, Poland.
    Background: Metabolic syndrome (MS) is a coexistence of metabolic risk factors affecting the development of cardiovascular diseases. Reactive oxygen species, which are excessively produced in MS, participate in its pathogenesis. Vitamins A, C and E are an important part of the non-enzymatic antioxidative barrier in humans. Read More

    More Than Ataxia: Hyperkinetic Movement Disorders in Childhood Autosomal Recessive Ataxia Syndromes.
    Tremor Other Hyperkinet Mov (N Y) 2016 16;6:368. Epub 2016 Jul 16.
    Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
    Background: The autosomal recessive ataxias are a heterogeneous group of disorders that are characterized by complex neurological features in addition to progressive ataxia. Hyperkinetic movement disorders occur in a significant proportion of patients, and may sometimes be the presenting motor symptom. Presentations with involuntary movements rather than ataxia are diagnostically challenging, and are likely under-recognized. Read More

    Establishment of reference values of α-tocopherol in plasma, red blood cells and adipose tissue in healthy children to improve the management of chylomicron retention disease, a rare genetic hypocholesterolemia.
    Orphanet J Rare Dis 2016 Aug 12;11(1):114. Epub 2016 Aug 12.
    INSERM U1060, INRA UMR 1397, INSA-Lyon, CarMeN Laboratory, Université Lyon 1, Lyon, France.
    Background: Chylomicron retention disease (CMRD), a rare genetic hypocholesterolemia, results in neuro-ophtalmologic damages, which can be prevented by high doses of vitamin E during infancy. In these patients, plasma vitamin E concentration is significantly reduced due to defects of chylomicron secretion. Vitamin E in adipose tissue (AT) and red blood cells (RBC) have been proposed as potential relevant biomarkers of vitamin E status but no reference values in children are available. Read More

    Keys to overcoming the challenge of diagnosing autosomal recessive spinocerebellar ataxia.
    Neurologia 2016 Jul 23. Epub 2016 Jul 23.
    Servicio de Neurología, Complexo Hospitalario Universitario, Santiago de Compostela, España. Electronic address:
    Introduction: Autosomal recessive spinocerebellar ataxia refers to a large group of diseases affecting the cerebellum and/or its connections, although they may also involve other regions of the nervous system. These diseases are accompanied by a wide range of systemic manifestations (cardiopathies, endocrinopathies, skeletal deformities, and skin abnormalities).

    Development: This study reviews current knowledge of the most common forms of autosomal recessive spinocerebellar ataxia in order to provide tips that may facilitate diagnosis. Read More

    Hereditary and metabolic myelopathies.
    Handb Clin Neurol 2016 ;136:769-85
    Department of Neurology, Vanderbilt University, Nashville, TN, USA. Electronic address:
    Hereditary and metabolic myelopathies are a heterogeneous group of neurologic disorders characterized by clinical signs suggesting spinal cord dysfunction. Spastic weakness, limb ataxia without additional cerebellar signs, impaired vibration, and positional sensation are hallmark phenotypic features of these disorders. Hereditary, and to some extent, metabolic myelopathies are now recognized as more widespread systemic processes with axonal loss and demyelination. Read More

    A New Old Treatment for Vitamin E Deficiency in Cholestasis.
    J Pediatr Gastroenterol Nutr 2016 Dec;63(6):577-578
    *Section of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Aurora †Colorado Clinical and Translational Sciences Institute, University of Colorado Denver ‡Digestive Health Institute, Children's Hospital Colorado, Aurora, CO.

    Oral Tocofersolan Corrects or Prevents Vitamin E Deficiency in Children With Chronic Cholestasis.
    J Pediatr Gastroenterol Nutr 2016 Dec;63(6):610-615
    *Pediatric Hepatology and Pediatric Liver Transplantation Unit, National Reference Centre for biliary atresia, Assistance Publique-Hôpitaux de Paris, Université Paris Sud, Hepatinov, Le Kremlin-Bicêtre, France †Center for Inherited metabolic Diseases, Karolinska University Hospital Solna, Stockholm, Sweden ‡Medical Department, Orphan Europe, Puteaux, France §Beatrix Childrens Hospital, University Medical Center Groningen, Groningen, The Netherlands ||Division of Paediatric Gastroenterology and Hepatology, Children's Hospital, Hannover Medical School, Hannover, Germany ¶Department of Paediatric Gastroenterology and Hepatology, Academisch Medisch Centrum, Amsterdam, The Netherlands #Department of Pediatric Gastroenterology and Hepatology, CHRU de Lille, Hôpital Jeanne de Flandre, Lille, France **Wilhelmina Childrens Hospital, University Medical Center Utrecht, Utrecht, The Netherlands ††INSERM U1174, Université Paris-Sud, Orsay, France.
    Objectives: D-Alpha-tocopheryl polyethylene glycol 1000 succinate (Tocofersolan, Vedrop), has been developed in Europe to provide an orally bioavailable source of vitamin E in children with cholestasis. The aim was to analyze the safety/efficacy of Vedrop in a large group of children with chronic cholestasis.

    Methods: Two hundred seventy-four children receiving Vedrop for vitamin E deficiency or for its prophylaxis were included from 7 European centers. Read More

    Ataxia with Vitamin E Deficiency May Present with Cervical Dystonia.
    Tremor Other Hyperkinet Mov (N Y) 2016 17;6:374. Epub 2016 May 17.
    Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
    Background: Ataxia with vitamin E deficiency (AVED) is an autosomal recessive disorder that usually presents with ataxia, areflexia, and proprioceptive and vibratory sensory loss. Dystonia has been reported rarely.

    Case Report: An 11-year-old female presented with dystonic head tremor and cervical and bilateral arm dystonia. Read More

    Changes in fat-soluble vitamin levels after gastrectomy for gastric cancer.
    Surg Today 2017 Feb 25;47(2):145-150. Epub 2016 May 25.
    Department of Surgery, School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
    Several authors have reported the relationship between gastric cancer risk and vitamins. However, there are few reports on fat-soluble vitamins after gastrectomy for gastric cancer. Fat malabsorption and suppression of food intake after gastrectomy for gastric cancer have been previously documented. Read More

    The rise, the fall and the renaissance of vitamin E.
    Arch Biochem Biophys 2016 Apr;595:100-8
    JM USDA-HNRCA at Tufts University, Vascular Biology Laboratory, 711 Washington St., Boston, MA 02111, USA.
    This review deals with the expectations of vitamin E ability of preventing or curing, as a potent antioxidant, alleged oxidative stress based ailments including cardiovascular disease, cancer, neurodegenerative diseases, cataracts, macular degeneration and more. The results obtained with clinical intervention studies have highly restricted the range of effectiveness of this vitamin. At the same time, new non-antioxidant mechanisms have been proposed. Read More

    Spontaneous decidualization in pseudopregnant rats with vitamin E deficiency.
    Biochem Biophys Res Commun 2016 May 28;473(4):828-33. Epub 2016 Mar 28.
    Graduate School of Peking Union Medical College, Beijing, People's Republic of China; Reproductive Physiology Laboratory, National Research Institute for Family Planning, Beijing, People's Republic of China. Electronic address:
    Successful implantation of an embryo requires adequate depth of invasion in the endometrium, which depends upon decidualization. The aim of the present study was to elucidate why humans experience spontaneous decidualization and menstruation while most other mammals do not. We established a spontaneous decidualization model in pseudopregnant rats with vitamin E deficiency (VED) to investigate mechanisms associated with spontaneous decidualization. Read More

    Eosinophilic Enteritis in Horses with Motor Neuron Disease.
    J Vet Intern Med 2016 May 26;30(3):873-9. Epub 2016 Mar 26.
    Veterinary Teaching Hospital and Department of Animal Medicine and Surgery, University of Cordoba, Cordoba, Spain.
    Background: Equine motor neuron disease (EMND) is a neuromuscular disorder that affects adult horses. Although EMND has been linked to vitamin E deficiency, its etiopathogenesis is poorly understood.

    Objectives: To describe clinical features, laboratory results, and postmortem findings in a series of young horses with motor neuron disease (MND). Read More

    A Case of Ataxia with Isolated Vitamin E Deficiency Initially Diagnosed as Friedreich's Ataxia.
    Case Rep Neurol Med 2016 16;2016:8342653. Epub 2016 Feb 16.
    The Walton Centre NHS Foundation Trust, Lower Lane, Liverpool L9 7LJ, UK.
    Ataxia with isolated vitamin E deficiency (AVED) is a rare autosomal recessive condition that is caused by a mutation in the alpha tocopherol transfer protein gene. It is almost indistinguishable clinically from Friedreich's ataxia but with appropriate treatment its devastating neurological features can be prevented. Patients can present with a progressive cerebellar ataxia, pyramidal spasticity, and evidence of a neuropathy with absent deep tendon reflexes. Read More

    α-Tocopherol in breast milk of women with preterm delivery after a single postpartum oral dose of vitamin E.
    Br J Nutr 2016 Apr 2;115(8):1424-30. Epub 2016 Mar 2.
    1Department of Biochemistry,Federal University of Rio Grande do Norte,Ave. Senador Salgado Filho 3000,Lagoa Nova,Natal,59072-970,Brazil.
    We evaluated the effect of maternal vitamin E supplementation on the α-tocopherol concentrations of colostrum, transitional milk and mature milk of women who had given birth prematurely. This longitudinal randomised-controlled trial divided eighty-nine women into two groups: a control group and a supplemented group. Blood and breast milk were collected from all the participants after delivery. Read More

    Long-Term Vitamin E-Deficient Mice Exhibit Cognitive Dysfunction via Elevation of Brain Oxidation.
    J Nutr Sci Vitaminol (Tokyo) 2015 ;61(5):362-8
    Physiological Chemistry Laboratory, Department of Bioscience and Engineering, College of Systems Engineering and Sciences, Shibaura Institute of Technology.
    Vitamin E inhibits oxidative processes in living tissues. We produced vitamin E-deficient mice by feeding them a vitamin E-deficient diet to verify the influence of chronic vitamin E deficiency on cognitive function. We measured cognitive function over a 5-d period using the Morris water maze task, as well as antioxidant enzyme activity and lipid peroxidation in discrete brain regions, and total serum cholesterol content. Read More

    Dietary exposure to aflatoxin and micronutrient status among young children from Guinea.
    Mol Nutr Food Res 2016 Mar 18;60(3):511-8. Epub 2015 Dec 18.
    Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, Belfast, UK.
    Scope: Aflatoxin exposure coincides with micronutrient deficiencies in developing countries. Animal feeding studies have postulated that aflatoxin exposure may be exacerbating micronutrient deficiencies. Evidence available in human subjects is limited and inconsistent. Read More

    α-Tocopherol bioavailability is lower in adults with metabolic syndrome regardless of dairy fat co-ingestion: a randomized, double-blind, crossover trial.
    Am J Clin Nutr 2015 Nov 7;102(5):1070-80. Epub 2015 Oct 7.
    Human Nutrition Program, Department of Human Sciences and
    Background: Increasing dietary fat intake is expected to improve α-tocopherol bioavailability, which could be beneficial for improving α-tocopherol status, especially in cohorts at high cardiometabolic risk who fail to meet dietary α-tocopherol requirements.

    Objective: Our objective was to assess dose-dependent effects of dairy fat and metabolic syndrome (MetS) health status on α-tocopherol pharmacokinetics in plasma and lipoproteins.

    Design: A randomized, crossover, double-blind study was conducted in healthy and MetS adults (n = 10/group) who ingested encapsulated hexadeuterium-labeled (d6)-RRR-α-tocopherol (15 mg) with 240 mL nonfat (0. Read More

    A Plasma α-Tocopherome Can Be Identified from Proteins Associated with Vitamin E Status in School-Aged Children of Nepal.
    J Nutr 2015 Dec 7;145(12):2646-56. Epub 2015 Oct 7.
    Departments of International Health.
    Background: The term vitamin E describes a family of 8 vitamers, 1 of which is α-tocopherol, that is essential for human health. Vitamin E status remains largely unknown in low-income countries because of the complexity and cost of measurement. Quantitative proteomics may offer an approach for identifying plasma proteins for assessing vitamin E status in these populations. Read More

    Focus on Pivotal Role of Dietary Intake (Diet and Supplement) and Blood Levels of Tocopherols and Tocotrienols in Obtaining Successful Aging.
    Int J Mol Sci 2015 Sep 25;16(10):23227-49. Epub 2015 Sep 25.
    Department of Public Health, Experimental and Forensic Medicine, School of Medicine, Endocrinology and Nutrition Unit, University of Pavia, Azienda di Servizi alla Persona di Pavia, Pavia 27100, Italy.
    Numerous specific age-related morbidities have been correlated with low intake and serum levels of tocopherols and tocotrienols. We performed a review in order to evaluate the extant evidence regarding: (1) the association between intake and serum levels of tocopherols and tocotrienols and age-related pathologies (osteoporosis, sarcopenia and cognitive impairment); and (2) the optimum diet therapy or supplementation with tocopherols and tocotrienols for the treatment of these abnormalities. This review included 51 eligible studies. Read More

    Effect of anti-hyperlipidemia drugs on the alpha-tocopherol concentration and their potential for murine malaria infection.
    Parasitol Res 2016 Jan 11;115(1):69-75. Epub 2015 Sep 11.
    Research Unit for Functional Genomics, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13, Inada-cho, Obihiro, Hokkaido, 080-8555, Japan.
    The current preventions of malaria are protection against mosquito bites and taking chemoprophylactic anti-malarial drugs. However, drug therapies are usually associated with adverse events and emergency of drug-resistant malaria parasites. Previous study showed that host plasma alpha-tocopherol deficiency enhanced resistance against malaria infection in mice. Read More

    Sheep deficient in vitamin E preferentially select for a feed with a higher concentration of vitamin E.
    Animal 2016 Feb 10;10(2):183-91. Epub 2015 Sep 10.
    2CSIRO Agriculture Flagship,Private Bag 5,Wembley,WA 6913,Australia.
    Given the capacity of ruminants to modify diet selection based on metabolic needs, we hypothesised that, when given a choice, lambs experiencing a vitamin E deficiency would consume more of a vitamin E-enriched feed than lambs not deficient in vitamin E. Fifty-six Dohne Merino lambs were divided into two groups and fed either a vitamin E-deficient diet over 40 days to induce low plasma vitamin E or a vitamin E-enriched diet to induce high plasma vitamin E. The lambs were then offered a choice of vitamin E-enriched and vitamin E-deficient pellets. Read More

    Suboptimal Serum α-Tocopherol Concentrations Observed among Younger Adults and Those Depending Exclusively upon Food Sources, NHANES 2003-20061-3.
    PLoS One 2015 19;10(8):e0135510. Epub 2015 Aug 19.
    Division of Nutritional Sciences, Cornell University, Ithaca, New York, United States of America.
    Vitamin E is an essential nutrient for human health, with an established function as a lipid-soluble antioxidant that protects cell membranes from free radical damage. Low vitamin E status has been linked to multiple health outcomes, including total mortality. With vitamin E being identified as a 'shortfall nutrient' because >90% of American adults are not consuming recommended amounts of vitamin E, we aimed to determine the prevalence of both clinical vitamin E deficiency (serum α-tocopherol concentration < 12 μmol/L) and failure to meet a criterion of vitamin E adequacy, serum α-tocopherol concentration of 30 μmol/L, based on the Estimated Average Requirement (EAR) and lowest mortality rate in the Alpha-Tocopherol Beta-Carotene (ATBC) study. Read More

    Antioxidant vitamins status in children and young adults undergoing dialysis: A single center study.
    Indian J Nephrol 2015 Jul-Aug;25(4):206-12
    Hemodialysis Section, Dr. Sheikh Children Hospital, Mashhad, Iran.
    Vitamin E and C are well-known antioxidant vitamins. Oxidative stress is common in chronic kidney diseases. We evaluated 43 dialysis subjects prospectively in a cross-sectional survey. Read More

    Mechanisms of recognition and binding of α-TTP to the plasma membrane by multi-scale molecular dynamics simulations.
    Front Mol Biosci 2015 1;2:36. Epub 2015 Jul 1.
    Department of Chemistry, Centre for Theoretical and Computational Chemistry, University of Oslo Oslo, Norway.
    We used multiple sets of simulations both at the atomistic and coarse-grained level of resolution to investigate interaction and binding of α-tochoperol transfer protein (α-TTP) to phosphatidylinositol phosphate lipids (PIPs). Our calculations indicate that enrichment of membranes with such lipids facilitate membrane anchoring. Atomistic models suggest that PIP can be incorporated into the binding cavity of α-TTP and therefore confirm that such protein can work as lipid exchanger between the endosome and the plasma membrane. Read More

    Bone mineral density in short bowel syndrome: correlation with BMI and serum vitamins C, E and K.
    Arch Endocrinol Metab 2015 Jun;59(3):252-8
    Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
    Objective: Bone loss has been established as a major extra-intestinal complication of short bowel syndrome (SBS). The purpose of this study was to correlate bone mineral density (BMD) with body mass index (BMI), serum vitamin and mineral levels in patients with SBS.

    Material And Methods: The study was conducted on 13 patients (8 male and 5 female, 54. Read More

    Blood levels of antioxidants during age-related macular degeneration treatment by rheohaemapheresis.
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2015 Sep 12;159(3):400-6. Epub 2015 Jun 12.
    3rd Department of Internal Medicine - Metabolic Care and Gerontology, Faculty of Medicine in Hradec Kralove, Charles University in Prague and University Hospital Hradec Kralove, Czech Republic.
    Aims: Rheohaemapheresis treatment influences rheological markers and most likely improves metabolism in affected retinal areas, resulting not only in absorption of soft drusen but also reduction or complete disappearance of drusenoid retinal pigment epithelium detachments. However, the character of the treatment process has raised suspicion that there is a decrease not only in cholesterol but also in antioxidants, such as vitamin E and vitamin A.

    Methods: Twenty-three patients with the progressive dry form of age-related macular degeneration were each treated with 8 procedures of rheohaemapheresis. Read More

    Molecular and clinical study of a cohort of 110 Algerian patients with autosomal recessive ataxia.
    BMC Med Genet 2015 Jun 12;16:36. Epub 2015 Jun 12.
    Laboratoire de Biologie Cellulaire et Moléculaire, Faculté des Sciences Biologiques, USTHB, Alger, Algeria.
    Background: Autosomal recessive cerebellar ataxias (ARCA) are a complex group of neurodegenerative disorders with great genetic and phenotypic heterogeneity, over 30 genes/loci have been associated with more than 20 different clinical forms of ARCA. Genetic heterogeneity combined with highly variable clinical expression of the cerebellar symptoms and overlapping features complicate furthermore the etiological diagnosis of ARCA. The determination of the most frequent mutations and corresponding ataxias, as well as particular features specific to a population, are mandatory to facilitate and speed up the diagnosis process, especially when an appropriate treatment is available. Read More

    Risk of Atherosclerosis in Patients with Ataxia Telangiectasia.
    Ann Nutr Metab 2015 4;66(4):196-201. Epub 2015 Jun 4.
    Pediatric Department, Universidade Federal de São Paulo, São Paulo, S.P., Brazil.
    Background And Aims: Evaluate the nutritional status, plasma concentration of vitamin E and markers of cardiovascular risk in ataxia telangiectasia (AT) patients.

    Methods: Cross-sectional study with 13 patients with AT and 22 healthy controls, evaluating the following factors: nutritional status, food intake, lipid profile, plasma concentration of vitamin E, malondialdehyde and high sensitivity C-reactive protein, linking them with atherosclerosis risk in AT patients.

    Results: Average age was 14. Read More

    A novel animal model of impaired glucose tolerance induced by the interaction of vitamin E deficiency and (60)Co radiation.
    Biomed Res Int 2015 14;2015:457246. Epub 2015 Apr 14.
    Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
    Impaired glucose tolerance (IGT), known as the prediabetes stage, is usually induced by habits of life or environmental factors. Established IGT animal models are mostly conducted with chemical compounds such as streptozocin or genetic modification. However, the occasion of exposure to these factors in daily life is seldom. Read More

    Effects of dietary vitamin E on fertility functions in poultry species.
    Int J Mol Sci 2015 Apr 30;16(5):9910-21. Epub 2015 Apr 30.
    Department of Animal Science and Technology, Chung-Ang University, Anseong, Gyeonggi-do 456-756, Korea.
    Vitamin E is found in high quantities in vegetable oils. Although vitamin E has multiple functions in humans and animals, its key function is protecting cells from oxidative damage. Since its discovery, several studies have demonstrated that vitamin E deficiency causes impaired fertility in humans and lab animals. Read More

    Serum α-Tocopherol Has a Nonlinear Inverse Association with Periodontitis among US Adults.
    J Nutr 2015 May 11;145(5):893-9. Epub 2015 Feb 11.
    Unilever Research and Development, Vlaardingen, The Netherlands;
    Background: Previous experimental models suggest that vitamin E may ameliorate periodontitis. However, epidemiologic studies show inconsistent evidence in supporting this plausible association.

    Objective: We investigated the association between serum α-tocopherol (αT) and γ-tocopherol (γT) and periodontitis in a large cross-sectional US population. Read More

    Vitamin E and neurodegeneration.
    Neurobiol Dis 2015 Dec 22;84:78-83. Epub 2015 Apr 22.
    Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. Electronic address:
    Alpha-tocopherol (vitamin E) is a plant-derived antioxidant that is essential for human health. Studies with humans and with animal models of vitamin E deficiency established the critical roles of the vitamin in protecting the central nervous system, and especially the cerebellum, from oxidative damage and motor coordination deficits. We review here the established roles of vitamin E in protecting cerebellar functions, as well as emerging data demonstrating the critical roles of alpha-tocopherol in preserving learning, memory and emotive responses. Read More

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