Chronic vitamin E deficiency impairs cognitive function in adult zebrafish via dysregulation of brain lipids and energy metabolism.
- Melissa McDougall,
- Jaewoo Choi,
- Kathy Magnusson,
- Lisa Truong,
- Robert Tanguay,
- Maret G Traber
Free Radic Biol Med 2017 Aug 5;112:308-317. Epub 2017 Aug 5.
Linus Pauling Institute, Oregon State University, Corvallis, OR 97330, USA; College of Public Health and Human Sciences, Oregon State University, Corvallis, OR 97330, USA. Electronic address:
Zebrafish (Danio rerio) are a recognized model for studying the pathogenesis of cognitive deficits and the mechanisms underlying behavioral impairments, including the consequences of increased oxidative stress within the brain. The lipophilic antioxidant vitamin E (α-tocopherol; VitE) has an established role in neurological health and cognitive function, but the biological rationale for this action remains unknown. In the present study, we investigated behavioral perturbations due to chronic VitE deficiency in adult zebrafish fed from 45 days to 18-months of age diets that were either VitE-deficient (E-) or VitE-sufficient (E+). Read More