3,964 results match your criteria Vitamin E Deficiency


Spontaneous Axonal Dystrophy in the Brain and Spinal Cord in Naïve Beagle Dogs.

Toxicol Pathol 2020 Jun 1:192623320926475. Epub 2020 Jun 1.

Global Pathology and Investigative Toxicology, Pfizer Inc, Groton, CT, USA.

Axonal dystrophy (AD) is a common age-related neurohistological finding in vertebrates that can be congenital or induced by xenobiotics, vitamin E deficiency, or trauma/compression. To understand the incidence and location of AD as a background finding in Beagle dogs used in routine toxicity studies, we examined central nervous system (CNS) and selected peripheral nervous system (PNS) tissues in twenty 18- to 24-month-old and ten 4- to 5-year-old control males and females. Both sexes were equally affected. Read More

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http://dx.doi.org/10.1177/0192623320926475DOI Listing

Increased anxiety-like behavior is an early symptom of vitamin E deficiency that is suppressed by adrenalectomy in rats.

Br J Nutr 2020 Jun 1:1-27. Epub 2020 Jun 1.

Department of Agricultural Chemistry, School of Agriculture, Meiji University, Kawasaki, Kanagawa214-8571, Japan.

We previously reported that dietary vitamin E deficiency increased anxiety-like behavior in rats exposed to social isolation. Here, we performed a detailed investigation of this phenomenon and its underlying mechanism. First, we fed Wistar rats with vitamin E-free diet for 3 days, 1 week, or 2 weeks and found an increase in anxiety-like behavior after 1 and 2 weeks of vitamin E deficiency based on behavioral indicators. Read More

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http://dx.doi.org/10.1017/S0007114520001889DOI Listing

Dietary Lipid Intake Influences the Alpha-tocopherol Levels in Human Milk.

J Pediatr Gastroenterol Nutr 2020 Jun;70(6):858-863

Federal University of Rio Grande do Norte, Natal.

Objective: Dietary lipid intake is associated with serum alpha-tocopherol levels; however, its impact on human milk is unknown. The objective of this study was to evaluate the relationship between maternal intake of vitamin E, lipids, and fatty acids and the concentration of alpha-tocopherol in human milk.

Methods: We conducted a longitudinal observational study, including 143 lactating women on 7, 30, and 90 days postpartum. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002668DOI Listing

Vitamin E deficiency ataxia in a family with possible cardiac involvement.

Neurologia 2020 Mar 14. Epub 2020 Mar 14.

Unidad de Trastornos del Movimiento, Servicio de Neurología, Hospital Universitari Vall d'Hebrón, Barcelona, España; Neurodegenerative Diseases Research Group, Vall d'Hebrón Research Institute (VHIR), Barcelona, España. Electronic address:

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http://dx.doi.org/10.1016/j.nrl.2020.02.001DOI Listing

Dietary Lipid Intake Influences the Alpha-Tocopherol Levels in Human Milk.

J Pediatr Gastroenterol Nutr 2020 Feb 19. Epub 2020 Feb 19.

Doctor, Professor, Federal University of Rio Grande do Norte, Ave. Senador Salgado Filho 3000, Lagoa Nova - 59072-970, Natal, Brazil.

Objective: Dietary lipid intake is associated with serum alpha-tocopherol levels; however, its impact on human milk is unknown. The objective of this study was to evaluate the relationship between maternal intake of vitamin E, lipids, and fatty acids and the concentration of alpha-tocopherol in human milk.

Methods: We conducted a longitudinal observational study, including 143 lactating women on 7, 30, and 90 days postpartum. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002668DOI Listing
February 2020

Brown Bowel Syndrome: A Multi-institutional Case Series.

Am J Surg Pathol 2020 Jun;44(6):834-837

University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

Brown bowel syndrome (BBS) is a rare condition associated with vitamin E deficiency and defined by prominent lipofuscin deposition in the muscularis propria. Eight unique cases of BBS were identified: 5 men and 3 women (mean age=58.6 y). Read More

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http://dx.doi.org/10.1097/PAS.0000000000001443DOI Listing

Ataxia with Vitamin E Deficiency with Predominant Cervical Dystonia.

Mov Disord Clin Pract 2020 Jan 30;7(1):100-103. Epub 2019 Dec 30.

Department of Neuroscience University of Kentucky Lexington Kentucky USA.

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http://dx.doi.org/10.1002/mdc3.12871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962681PMC
January 2020

Nutritional neuropathies.

Muscle Nerve 2019 Dec 14. Epub 2019 Dec 14.

University of Virginia, Charlottesville, Virginia.

Neuropathies associated with nutritional deficiencies are routinely encountered by the practicing neurologist. Although these neuropathies assume different patterns, most are length-dependent, sensory axonopathies. Cobalamin deficiency neuropathy is the exception, often presenting with a non-length-dependent sensory neuropathy. Read More

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http://dx.doi.org/10.1002/mus.26783DOI Listing
December 2019

Next generation sequencing and RNA-seq characterization of adipose tissue in the Nile crocodile (Crocodylus niloticus) in South Africa: Possible mechanism(s) of pathogenesis and pathophysiology of pansteatitis.

PLoS One 2019 18;14(11):e0225073. Epub 2019 Nov 18.

Anatomy and Physiology Dept., Faculty of Veterinary Science, University of Pretoria, Onderstepoort, Pretoria, South Africa.

Background: Concerted efforts to identify the pathogenesis and mechanism(s) involved in pansteatitis, (a generalized inflammation of the adipose tissue), that was attributed to the recent crocodile die off in the Olifants River and Loskop Dam in Kruger National Park, Mpumalanga, South Africa have been in the forefront of research in recent time. As part of the efforts, molecular characterization of healthy and pansteatitis adipose tissue was carried out by RNA sequencing (RNA-Seq) using Next Generation Sequencing (NGS) and de novo assembly of the adipose transcriptome, followed by differential gene expression analysis.

Methodology: Healthy adipose tissue consisting of fifty samples was collected from the subcutaneous, visceral, intermuscular adipose tissues and the abdominal fat body of ten 4 years old juvenile crocodiles from a local crocodile farm in Pretoria, South Africa. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0225073PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861000PMC

Single-Cell RNA-seq Reveals Profound Alterations in Mechanosensitive Dorsal Root Ganglion Neurons with Vitamin E Deficiency.

iScience 2019 Nov 31;21:720-735. Epub 2019 Oct 31.

Department of Physiology, School of Medicine, University of Nevada, Reno, Reno, NV 89557, USA.

Ninety percent of Americans consume less than the estimated average requirements of dietary vitamin E (vitE). Severe vitE deficiency due to genetic mutations in the tocopherol transfer protein (TTPA) in humans results in ataxia with vitE deficiency (AVED), with proprioceptive deficits and somatosensory degeneration arising from dorsal root ganglia neurons (DRGNs). Single-cell RNA-sequencing of DRGNs was performed in Ttpa mice, an established model of AVED. Read More

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http://dx.doi.org/10.1016/j.isci.2019.10.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864320PMC
November 2019

Multiple Micronutrient Powder Reduces Vitamin E Deficiency in Brazilian Children: A Pragmatic, Controlled Clinical Trial.

Nutrients 2019 Nov 11;11(11). Epub 2019 Nov 11.

Graduate Program in Health Sciences, Faculty of Medicine, Federal University of Goiás, Goiânia, Goiás 74605-020, Brazil.

Multiple micronutrient powder supplementation is a health promotion strategy, but data on its effectiveness regarding vitamin E are rare. The objective was to evaluate the impact of home fortification with powdered micronutrients on α-tocopherol concentrations, growth, and inflammation in Brazilian children aged 6-15 months. This is a pragmatic, controlled clinical trial, in which the intervention group received micronutrient powder sachets for up to 3 months. Read More

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http://dx.doi.org/10.3390/nu11112730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893530PMC
November 2019

Impact of alpha-tocopherol deficiency and supplementation on sacrocaudalis and gluteal muscle fiber histopathology and morphology in horses.

J Vet Intern Med 2019 Nov 29;33(6):2770-2779. Epub 2019 Oct 29.

McPhail Equine Performance Center, Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, Michigan.

Background: A subset of horses deficient in alpha-tocopherol (α-TP) develop muscle atrophy and vitamin E-responsive myopathy (VEM) characterized by mitochondrial alterations in the sacrocaudalis dorsalis medialis muscle (SC).

Objectives: To quantify muscle histopathologic abnormalities in subclinical α-TP deficient horses before and after α-TP supplementation and compare with retrospective (r)VEM cases.

Animals: Prospective study; 16 healthy α-TP-deficient Quarter Horses. Read More

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http://dx.doi.org/10.1111/jvim.15643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872615PMC
November 2019

Previously Identified Genetic Variants in Are not Associated with Risk for Equine Degenerative Myeloencephalopathy across Breeds.

Genes (Basel) 2019 09 5;10(9). Epub 2019 Sep 5.

Department of Population, Health and Reproduction at the University of California, Davis, Davis, CA 95616, USA.

Equine neuroaxonal dystrophy/equine degenerative myeloencephalopathy (eNAD/EDM) is a neurologic disease that has been reported in young horses from a wide range of breeds. The disease is inherited and associated with vitamin E deficiency during the first two years of life, resulting in bilateral symmetric ataxia. A missense mutation (chr3:71,917,591 C > T) within adhesion G protein-coupled receptor L3 () was recently associated with risk for EDM in the Caspian breed. Read More

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http://dx.doi.org/10.3390/genes10090681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770705PMC
September 2019
1 Read

Subacute combined degeneration associated with vitamin E deficiency due to small bowel obstruction: A case report.

Medicine (Baltimore) 2019 Sep;98(36):e17052

Department of Neurology, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Republic of Korea.

Rationale: There have been a few reported cases of subacute combined degeneration (SCD) associated with vitamin E deficiency, but the period of intestinal malabsorption was more than several years. We present a rare case of acute onset SCD that occurred in a relatively short period of several weeks with vitamin E deficiency related to small bowel obstruction.

Patient Concerns: A 50-year-old woman had abdominal pain. Read More

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http://dx.doi.org/10.1097/MD.0000000000017052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738987PMC
September 2019
4 Reads

Ataxia.

Authors:
Sheng-Han Kuo

Continuum (Minneap Minn) 2019 Aug;25(4):1036-1054

Purpose Of Review: This article reviews the symptoms, laboratory and neuroimaging diagnostic tests, genetics, and management of cerebellar ataxia.

Recent Findings: Recent advances in genetics have led to the identification of novel genetic causes for ataxia and a more comprehensive understanding of the biological pathways critical for normal cerebellar function. When these molecular pathways become dysfunctional, patients develop cerebellar ataxia. Read More

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http://dx.doi.org/10.1212/CON.0000000000000753DOI Listing
August 2019
14 Reads

Tocopherols, tocotrienols and tocomonoenols: Many similar molecules but only one vitamin E.

Authors:
Angelo Azzi

Redox Biol 2019 09 19;26:101259. Epub 2019 Jun 19.

Sackler School of Graduate Biomedical Pharmacology and Drug Development Program, Tufts University, 75 Kneeland Street, Boston, MA, 02111, USA. Electronic address:

The aim of this article is to correct a very general error in scientific articles, in textbooks and in the Internet that has become an accepted fact. In this literature, the term "vitamin E″ is used for several similar molecules (both tocopherols and tocotrienols) that have never been shown to have vitamin property, i.e. Read More

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http://dx.doi.org/10.1016/j.redox.2019.101259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604160PMC
September 2019
4 Reads

Dietary vitamin E deficiency inhibits fat metabolism, antioxidant capacity, and immune regulation of inflammatory response in genetically improved farmed tilapia (GIFT, Oreochromis niloticus) fingerlings following Streptococcus iniae infection.

Fish Shellfish Immunol 2019 Sep 18;92:395-404. Epub 2019 Jun 18.

Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi, 214081, Jiangsu, China.

Vitamin E plays an important role in maintaining normal metabolism and physiological functions in animals. The health of fish fingerlings directly affects the rate of disease incidence in adult fish, and healthy fingerlings ultimately result in better breeding outcomes for cultured fish. To date, no previous studies have focused on the effects vitamin E deficiency on tilapia at the fingerling stage. Read More

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http://dx.doi.org/10.1016/j.fsi.2019.06.026DOI Listing
September 2019
10 Reads

Vitamin E status in healthy population in Asia: a review of current literature.

Int J Vitam Nutr Res 2019 May 24:1-14. Epub 2019 May 24.

1 Institute of Home Economics, University of Delhi, India.

Vitamin E is a lipid soluble antioxidant which mainly circulates as α-tocopherol in the human plasma. Its deficiency is associated with ataxia, neuropathy, anaemia and several other health conditions. Although substantial data on vitamin E status has been published worldwide, there is paucity of data on the extent of deficiency from most Asian countries, including India. Read More

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http://dx.doi.org/10.1024/0300-9831/a000590DOI Listing
May 2019
10 Reads

Vitamins in diet of patients with metabolic syndrome.

Ter Arkh 2019 Mar;91(2):118-125

Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russia.

Aim - analysis of data on the role of vitamin and carotenoid deficiency in the development of metabolic syndrome (MS), the consumption of individual vitamins and vitamin supplements, as well as estimation of the effectiveness of the use of vitamins in patients with MS. A review of the existing literature has been carried out in the databases of RINC, CyberLeninka, Google Scholar, Pubmed. The lack of vitamins is a risk factor for MS and its components. Read More

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http://ter-arkhiv.ru/en/archive/2019/vol-91-2-2019/vitamins-
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http://dx.doi.org/10.26442/00403660.2019.02.000097DOI Listing
March 2019
14 Reads

[Trend of vitamin A and vitamin E among pregnancy of Beijing in 2013-2016].

Wei Sheng Yan Jiu 2019 Jan;48(1):56-60

Department of Obstetrics and Gynecology, Beijing Luhe Hospital, Capital Medical University, Beijing 101100, China.

Objective: To describe the nutrition level of vitamin A and vitamin E among pregnancy of Beijing and the trends from 2013 to 2016.

Methods: A total of 5487 serum samples from pregnant women who simultaneous detection for the first time from January 2013 to December 2016 in Beijing were enrolled in the study, then high performance liquid chromatography(HPLC) method was used to determine the concentration of serum vitamin A and vitamin E, and it was compared with serum concentrations of vitamin A, vitamin E in normal people. Qualitative analysis of the trend of vitamin A and vitamin E nutrition in pregnant women from 2013 to 2016. Read More

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January 2019
6 Reads

Factors Associated with Increased Alpha-Tocopherol Content in Milk in Response to Maternal Supplementation with 800 IU of Vitamin E.

Nutrients 2019 Apr 22;11(4). Epub 2019 Apr 22.

Department of Biochemistry, Federal University of Rio Grande do Norte, 59078-970 Natal-RN, Brazil.

Background: Vitamin E supplementation might represent an efficient strategy to increase the vitamin E content in milk. The present study aimed to evaluate the impact of supplementation with 800 IU RRR-alpha-tocopherol on the alpha-tocopherol content of milk and the factors associated with the increase in vitamin E.

Methods: Randomized clinical trial with 79 lactating women from Brazil, who were assigned to the control group, or to the supplemented group (800 IU of RRR-alpha-tocopherol). Read More

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http://dx.doi.org/10.3390/nu11040900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520676PMC
April 2019
5 Reads

"No-No" Head Tremor-A Nod to the Diagnosis.

Pediatr Neurol 2019 11 19;100:104. Epub 2019 Mar 19.

Department of Neurology and Neurophysiology, Temple Street Children's University Hospital, Dublin, Ireland; Academic Centre on Rare Diseases, School of Medicine and Medical Science, University College Dublin, Ireland.

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https://linkinghub.elsevier.com/retrieve/pii/S08878994193002
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http://dx.doi.org/10.1016/j.pediatrneurol.2019.03.007DOI Listing
November 2019
26 Reads

Brown bowel syndrome: a rare malnutrition-related complication of bariatric surgery.

Nutr Hosp 2019 Jul;36(3):743-747

Department of Surgery. Faculty of Medical Sciences. Universidade Estadual de Campinas (UNICAMP).

Introduction: Case report: we present the case of a 44-year-old male who presented with uncontrollable diarrhea, severe protein-calorie malnutrition and multiple vitamin deficiencies, along with peripheral neuropathy ten years after classic biliopancreatic diversion (BPD). He underwent nutritional support and had the surgery converted to a Roux-en-Y gastric bypass, with an uneventful outcome. The histopathology of the resected bowel revealed lipofuscinosis of the muscular layer compatible with brown bowel syndrome. Read More

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http://dx.doi.org/10.20960/nh.2257DOI Listing
July 2019
7 Reads

Anthropometric Profile, Serum Leptin, Antioxidant Vitamins, LEPR Q223R Polymorphism and Cardiovascular Risk Factors in Adolescents.

Int J Vitam Nutr Res 2018 Feb 15;88(1-2):27-38. Epub 2019 Apr 15.

5 School of Medicine and Surgery Federal University of Rio de Janeiro State, Brazil.

Cardiovascular disease (CVD) risk factors, such as bad eating habits, are typical in adolescence and lead to the consumption of meals that are not always sufficient in vitamins A, E, -carotene, excess calories and elevated serum leptin levels. The purpose of this research is to study the relationship between vitamin A deficiency (VAD), -carotene deficiency (cD), vitamin E deficiency (VED) and to explore the association of leptin receptor Q223R polymorphisms with obesity and other risk factors for CVD. This observational study included 237 adolescents recruited from Adolescents Reference Center, Brazil. Read More

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http://dx.doi.org/10.1024/0300-9831/a000274DOI Listing
February 2018
9 Reads

Familial vitamin E deficiency: Multiorgan complications support the adverse role of oxidative stress.

Nutrition 2019 Jul - Aug;63-64:57-60. Epub 2018 Dec 1.

Department of Medicine, University of Padova, Padova, Italy. Electronic address:

Vitamin E is an essential micronutrient with relevant antioxidant and anti-inflammatory properties found in plant leaves, seeds, and products derived from their processing. Familial vitamin E deficiency is a rare inherited syndrome characterized by ataxia and peripheral neuropathy with a massive decrease in plasma vitamin E (<0.5 mg/dL). Read More

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http://dx.doi.org/10.1016/j.nut.2018.11.012DOI Listing
December 2018
8 Reads

Low Oleic/Stearic Desaturation Index in Great Blue Herons () with Steatitis in Southern California, USA.

J Wildl Dis 2019 Oct 11;55(4):995-999. Epub 2019 Mar 11.

Department of Medicine, Division of Endocrinology, 1501 N Campbell Avenue, Room 6408, University of Arizona, Tucson, Arizona 85724, USA.

We explored differences between the adipose tissue fatty acid profiles of Great Blue Herons () with and without steatitis. Adipose tissue from birds with steatitis exhibited inflammatory cell infiltration, low abundance of oleic acid, and a lower oleic/stearic desaturation index compared with tissue from birds without steatitis. Read More

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October 2019
4 Reads

IUBMB-Life 2019: Vitamin E-Regulatory Roles.

Authors:
Jean-Marc Zingg

IUBMB Life 2019 04 11;71(4):409-410. Epub 2019 Feb 11.

Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL, USA.

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http://dx.doi.org/10.1002/iub.2017DOI Listing
April 2019
1 Read

Vitamin E: Regulatory role on gene and protein expression and metabolomics profiles.

IUBMB Life 2019 04 11;71(4):442-455. Epub 2019 Jan 11.

Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul, South Korea.

Results from microarray analyzes have shown that both vitamin E deficiency and supplementation have a significant impact on the gene expression of various tissues and cells. Genes that were modulated by vitamin E supplementation were different depending on the tissue, which suggested that changes in gene expression are reflective of tissue function and the tissue-specific regulation of vitamin E. In addition, the magnitude of gene expression and types of genes whose expression was altered were differentially affected by the vitamin E forms used for intervention. Read More

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http://doi.wiley.com/10.1002/iub.2003
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http://dx.doi.org/10.1002/iub.2003DOI Listing
April 2019
29 Reads

Vitamin C and vitamin E double-deficiency increased neuroinflammation and impaired conditioned fear memory.

Arch Biochem Biophys 2019 03 8;663:120-128. Epub 2019 Jan 8.

Molecular Regulation of Aging, Tokyo Metropolitan Institute of Gerontology, Japan. Electronic address:

Background: Vitamin C (l-ascorbic acid, VC) and vitamin E (α-tocopherol, VE) play important physiological roles as endogenous antioxidants in many tissues and organs. However, their roles in the brain remain entirely elusive. We established senescence marker protein 30 (SMP30)/α-tocopherol transfer protein (αTTP) double knockout (DKO) mice as a novel VC and VE double-deficiency model and examined the effect of VC and VE double-deficiency on brain functions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00039861183084
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http://dx.doi.org/10.1016/j.abb.2019.01.003DOI Listing
March 2019
25 Reads

Brain Vitamin E Deficiency During Development Is Associated With Increased Glutamate Levels and Anxiety in Adult Mice.

Front Behav Neurosci 2018 11;12:310. Epub 2018 Dec 11.

LipSTIC LabEx, Fondation de Coopération Scientifique Bourgogne-Franche Comté, Dijon, France.

Vitamin E, the most important lipophilic radical scavenging antioxidant , has a pivotal role in brain. In an earlier study, we observed that adult mice with a defect in the gene encoding plasma phospholipid transfer protein (PLTP) display a moderate reduction in cerebral vitamin E levels, and exacerbated anxiety despite normal locomotion and memory functions. Here we sought to determine whether dietary vitamin E supplementation can modulate neurotransmitter levels and alleviate the increased anxiety phenotype of PLTP-deficient () mice. Read More

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http://dx.doi.org/10.3389/fnbeh.2018.00310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297247PMC
December 2018
9 Reads

Potential of Vitamin E Deficiency, Induced by Inhibition of α-Tocopherol Efflux, in Murine Malaria Infection.

Int J Mol Sci 2018 Dec 24;20(1). Epub 2018 Dec 24.

Research Unit for Functional Genomics, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13, Inada, Obihiro 080-8555, Japan.

Although epidemiological and experimental studies have suggested beneficial effects of vitamin E deficiency on malaria infection, it has not been clinically applicable for the treatment of malaria owing to the significant content of vitamin E in our daily food. However, since α-tocopherol transfer protein (α-TTP) has been shown to be a determinant of vitamin E level in circulation, manipulation of α-tocopherol levels by α-TTP inhibition was considered as a potential therapeutic strategy for malaria. Knockout studies in mice indicated that inhibition of α-TTP confers resistance against malaria infections in murines, accompanied by oxidative stress-induced DNA damage in the parasite, arising from vitamin E deficiency. Read More

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http://dx.doi.org/10.3390/ijms20010064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337606PMC
December 2018
6 Reads

[Vitamin status of adult population of the Russian Federation: 1987-2017].

Vopr Pitan 2018 13;87(4):62-68. Epub 2018 Jul 13.

Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow.

In a review in order to characterize the dynamics of vitamin status for the period from 1987 to the present, the results of 16 surveys (conducted in 2015-2017) of the sufficiency with vitamins C, A, E, B2 and B6 of adult men and women of working age (about 1200 people) living in different regions of the Russian Federation, were compared with the frequency of vitamin insufficiency among the population in the previous period. The statistically significant improvement in the population's supply with vitamin C in the previous decade continued in 2015-2017. The deficit of this vitamin practically ceased to occur. Read More

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http://dx.doi.org/10.24411/0042-8833-2018-10043DOI Listing
April 2019
5 Reads

Vitamin E deficiency in South Asian population and the therapeutic use of alpha-tocopherol (Vitamin E) for correction of anemia.

Pak J Med Sci 2018 Nov-Dec;34(6):1571-1575

Prof. Dr. Mohammad Perwaiz Iqbal, PhD. Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan.

Mild to moderate vitamin E deficiency because of inadequate consumption of vitamin E-rich foods and intestinal fat malabsorption is common in growing children, women of reproductive age and elderly South Asian population. Severe vitamin E deficiency may lead to peripheral and motor neurodegenerative diseases (e.g ataxia and motor skeletal myopathy), impaired immune response and free radical-induced hemolytic anemias. Read More

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http://pjms.com.pk/index.php/pjms/article/view/15880
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http://dx.doi.org/10.12669/pjms.346.15880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290196PMC
December 2018
33 Reads

Movement Disorders in Treatable Inborn Errors of Metabolism.

Mov Disord 2019 05 17;34(5):598-613. Epub 2018 Dec 17.

Department of Pediatric and Adult Movement Disorders and Neuropsychiatry, Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.

There are several hundred single-gene disorders that we classify as inborn errors of metabolism. Inborn errors of metabolism are often rare and highly heterogeneous multisystem diseases with non-neurological and neurological manifestations, commonly with onset during childhood. Movement disorders are among the most common neurological problems in inborn errors of metabolism, but, in many cases, remain poorly defined. Read More

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http://dx.doi.org/10.1002/mds.27568DOI Listing

Vitamin E: Mechanism of transport and regulation in the CNS.

IUBMB Life 2019 04 17;71(4):424-429. Epub 2018 Dec 17.

Ursuline College, Department of Biology, 2550 Lander Rd Pepper Pike, Ohio 44124.

Although vitamin E has been recognized as a critical micronutrient to neuronal health for more than half a century, vitamin E transport and regulation in the brain remain a mystery. Currently, the majority of what is known about vitamin E transport has been delineated in the liver. However, clues from the pathogenesis of neurological-related vitamin E deficient diseases point to compromised neuronal integrity and function, underlining the critical need to understand vitamin E regulation in the CNS. Read More

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http://dx.doi.org/10.1002/iub.1993DOI Listing
April 2019
20 Reads

Vitamin E - The Next 100 Years.

IUBMB Life 2019 04 14;71(4):411-415. Epub 2018 Dec 14.

Vascular Biology Laboratory, JM USDA-HNRCA at Tufts University, Boston, Massachusetts.

α-Tocopherol is the only tocopherol that has been shown to prevent the human deficiency disease Ataxia with Isolated Vitamin E Deficiency (AVED), and thus it is the only one that, for humans, can be called vitamin E. Vitamin E in addition to preventing AVED has documented immune boosting properties and an activity against nonalcoholic hepatosteatosis and low-grade inflammation. Epidemiological studies indicating that vitamin E could prevent cardiovascular events, neurodegenerative disease, macular degeneration, and cancer were in general not confirmed by clinical intervention studies. Read More

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http://dx.doi.org/10.1002/iub.1990DOI Listing
April 2019
6 Reads

Regulatory role of vitamin E in the immune system and inflammation.

IUBMB Life 2019 04 30;71(4):487-494. Epub 2018 Nov 30.

Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, 02111, USA.

Vitamin E, a potent lipid-soluble antioxidant, found in higher concentration in immune cells compared to other cells in blood, is one of the most effective nutrients known to modulate immune function. Vitamin E deficiency has been demonstrated to impair normal functions of the immune system in animals and humans, which can be corrected by vitamin E repletion. Although deficiency is rare, vitamin E supplementation above current dietary recommendations has been shown to enhance the function of the immune system and reduce risk of infection, particularly in older individuals. Read More

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http://doi.wiley.com/10.1002/iub.1976
Publisher Site
http://dx.doi.org/10.1002/iub.1976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011499PMC
April 2019
17 Reads

Avian selenogenome: response to dietary Se and vitamin E deficiency and supplementation.

Poult Sci 2019 Oct;98(10):4247-4254

Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing 100083, China.

Selenium (Se) is an essential nutrient for humans and all food-producing animal species. Nutritional deficiencies of Se and (or) vitamin E induce exudative diathesis, nutritional pancreatic atrophy, and nutritional muscular dystrophy in chicks. Although these diseases are presumably associated with the need of Se for the synthesis of the 21st amino acid, selenocysteine (Sec, U) in selenoproteins, metabolic functions of the 25 selenoproteins identified in avian species remain largely unknown. Read More

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http://dx.doi.org/10.3382/ps/pey408DOI Listing
October 2019
13 Reads

Prevalence and factors associated with fat-soluble vitamin deficiency in adolescents.

Nutr Hosp 2018 Oct 5;35(5):1153-1162. Epub 2018 Oct 5.

Background: fat-soluble vitamin deficiency may be a health problem not recognized in children and adolescents.

Objective: to estimate the prevalence and factors associated with the deficiency of vitamins A, D and E among adolescent students from Northeastern Brazil.

Methods: transversal study with adolescents aged 12 to 19 of both genders. Read More

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http://dx.doi.org/10.20960/nh.1785DOI Listing
October 2018
8 Reads

Chronic Complications of Cholestasis: Evaluation and Management.

Authors:
David N Assis

Clin Liver Dis 2018 08 28;22(3):533-544. Epub 2018 May 28.

Department of Medicine, Section of Digestive Diseases, Yale University School of Medicine, 333 Cedar Street, 1080 LMP, New Haven, CT 06510, USA. Electronic address:

Patients with primary biliary cholangitis (PBC) are at risk for various harmful consequences of chronic cholestasis. These include fat-soluble vitamin deficiency, even in the setting of macronutrient sufficiency, as well as metabolic bone disease, including osteoporosis with fractures. Hyperlipidemia is often present and less commonly associated with risk of cardiovascular event; however, the long-term effect of new emerging therapies for PBC remains to be determined. Read More

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http://dx.doi.org/10.1016/j.cld.2018.03.014DOI Listing
August 2018
9 Reads

Thalassemia, cholangiocarcinoma, and Vitamin E deficiency: A scenario in endemic area inSoutheast Asia.

J Cancer Res Ther 2018 Jul-Sep;14(5):1164-1165

Department of Tropical Medicine, Hainan Medical University, Hainan, China.

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http://dx.doi.org/10.4103/0973-1482.187386DOI Listing
December 2018
10 Reads

Vitamin E status and its determinants in patients with cystic fibrosis.

Adv Med Sci 2018 Sep 3;63(2):341-346. Epub 2018 Aug 3.

Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznan, Poland. Electronic address:

Purpose: The risk of vitamin E deficiency is of primary concern in cystic fibrosis patients. However, early diagnosis and routine vitamin E supplementation can lead to its normal or even high levels. In the present study, we assessed vitamin E status in a large group of cystic fibrosis patients. Read More

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http://dx.doi.org/10.1016/j.advms.2018.04.001DOI Listing
September 2018
46 Reads

Exocrine Pancreatic Insufficiency and Malnutrition in Chronic Pancreatitis: Identification, Treatment, and Consequences.

Pancreas 2018 09;47(8):1015-1018

Division of Gastroenterology, and.

Objectives: The purpose of this study was to examine the impact of exocrine pancreatic insufficiency (EPI) on chronic pancreatitis (CP) patients and to identify challenges with its diagnosis and treatment.

Methods: Ninety-one patients with CP diagnosed with endoscopic ultrasound were identified and assessed for symptoms of EPI, fat-soluble vitamin levels, dual-energy x-ray absorptiometry scan T-scores, and treatment with pancreatic enzyme replacement therapy. All patients were also screened with the Malnutrition Universal Screening Test. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462188PMC
September 2018
16 Reads

Efficacy of two vitamin E formulations in patients with abetalipoproteinemia and chylomicron retention disease.

J Lipid Res 2018 09 18;59(9):1640-1648. Epub 2018 Jul 18.

INSERM U1060, INRA UMR 1397, INSA-Lyon, CarMeN Laboratory, Université Lyon 1, Lyon, France

Abetalipoproteinemia (ABL) and chylomicron retention disease (CMRD) are extremely rare recessive forms of hypobetalipoproteinemia characterized by intestinal lipid malabsorption and severe vitamin E deficiency. Vitamin E is often supplemented in the form of fat-soluble vitamin E acetate, but fat malabsorption considerably limits correction of the deficiency. In this crossover study, we administered two different forms of vitamin E, tocofersolan (a water-soluble derivative of RRR-α-tocopherol) and α-tocopherol acetate, to three patients with ABL and four patients with CMRD. Read More

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http://dx.doi.org/10.1194/jlr.M085043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121919PMC
September 2018
37 Reads

Vitamin E supplementation in people with cystic fibrosis: A Cochrane review summary.

Authors:
J Dru Riddle

Int J Nurs Stud 2019 Sep 1;97:132-133. Epub 2018 Jun 1.

Director Center for Translational Research, Texas Christian University, Harris College of Nursing and Health Sciences, School of Nurse Anesthesia, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ijnurstu.2018.05.018DOI Listing
September 2019
2 Reads

Laboratory investigations.

Handb Clin Neurol 2018 ;154:287-298

Department of Pediatric Neurology, University Children's Hospital, University of Zurich, Zurich, Switzerland; Departments of Neurology and Ophthalmology, University Hospital Zurich, University of Zurich, Switzerland.

This chapter deals with chemical and hematologic investigations which are often considered in the diagnostic workup of subacute to chronic cerebellar ataxias. Relevant investigations in blood (serum, plasma), urine, and cerebrospinal fluid are discussed. Particular attention is paid to early diagnosis of treatable metabolic ataxias (such as abetalipoproteinemia, coenzyme Q10 deficiency, cerebrotendinous xanthomatosis, glucose transporter type 1 deficiency, Refsum disease, and vitamin E deficiency), but autoimmune ataxias, other vitamin deficiencies, and endocrine disorders should also be kept in mind. Read More

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https://linkinghub.elsevier.com/retrieve/pii/B97804446395610
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http://dx.doi.org/10.1016/B978-0-444-63956-1.00017-5DOI Listing
September 2018
47 Reads

Recessive ataxias.

Handb Clin Neurol 2018 ;155:73-89

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom; Oxford Centre for Genomic Medicine, Oxford University Hospitals NHS Trust, Oxford, United Kingdom.

Recessive ataxias (spinocerebellar ataxias, recessive or SCARs) are a heterogeneous group of rare, mostly neurodegenerative genetic disorders which usually start in childhood or early adult life. They can be subdivided into two major groups: predominant sensory or afferent ataxias, which are disorders mainly of the peripheral input to the cerebellum, and predominant cerebellar ataxias, in which the cerebellum is primarily affected. Next-generation sequencing technology has enabled the identification of >100 novel SCAR genes in the last 5 years, although most of them are ultrarare. Read More

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http://dx.doi.org/10.1016/B978-0-444-64189-2.00005-6DOI Listing
October 2018
9 Reads

Spastic ataxias.

Handb Clin Neurol 2018 ;155:191-203

Neuroscience Axis, CHU de Québec-Laval University, Quebec, QC, Canada; Neuromuscular and Neurogenetic Disease Clinic, CHU de Québec-Laval University, Quebec, QC, Canada. Electronic address:

The presence of spasticity and pyramidal features is a hallmark of some of hereditary ataxias, such as autosomal-recessive spastic ataxia of Charlevoix-Saguenay, other primary spastic ataxias, Friedreich ataxia, or ataxia with isolated vitamin E deficiency. Certain spastic paraplegias, such as spastic paraplegia 7, may present as an ataxic phenotype and often share common pathophysiologic pathways with cerebellar ataxias. Because of the rarity and genetic heterogeneity of these conditions, their molecular diagnosis remains challenging and time consuming. Read More

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http://dx.doi.org/10.1016/B978-0-444-64189-2.00012-3DOI Listing
October 2018
12 Reads