3,926 results match your criteria Vitamin E Deficiency


Vitamin E: Regulatory role on gene and protein expression and metabolomics profiles.

IUBMB Life 2019 Jan 11. Epub 2019 Jan 11.

Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul, South Korea.

Results from microarray analyzes have shown that both vitamin E deficiency and supplementation have a significant impact on the gene expression of various tissues and cells. Genes that were modulated by vitamin E supplementation were different depending on the tissue, which suggested that changes in gene expression are reflective of tissue function and the tissue-specific regulation of vitamin E. In addition, the magnitude of gene expression and types of genes whose expression was altered were differentially affected by the vitamin E forms used for intervention. Read More

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http://doi.wiley.com/10.1002/iub.2003
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http://dx.doi.org/10.1002/iub.2003DOI Listing
January 2019
1 Read

Brain Vitamin E Deficiency During Development Is Associated With Increased Glutamate Levels and Anxiety in Adult Mice.

Front Behav Neurosci 2018 11;12:310. Epub 2018 Dec 11.

LipSTIC LabEx, Fondation de Coopération Scientifique Bourgogne-Franche Comté, Dijon, France.

Vitamin E, the most important lipophilic radical scavenging antioxidant , has a pivotal role in brain. In an earlier study, we observed that adult mice with a defect in the gene encoding plasma phospholipid transfer protein (PLTP) display a moderate reduction in cerebral vitamin E levels, and exacerbated anxiety despite normal locomotion and memory functions. Here we sought to determine whether dietary vitamin E supplementation can modulate neurotransmitter levels and alleviate the increased anxiety phenotype of PLTP-deficient () mice. Read More

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http://dx.doi.org/10.3389/fnbeh.2018.00310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297247PMC
December 2018

Potential of Vitamin E Deficiency, Induced by Inhibition of α-Tocopherol Efflux, in Murine Malaria Infection.

Int J Mol Sci 2018 Dec 24;20(1). Epub 2018 Dec 24.

Research Unit for Functional Genomics, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13, Inada, Obihiro 080-8555, Japan.

Although epidemiological and experimental studies have suggested beneficial effects of vitamin E deficiency on malaria infection, it has not been clinically applicable for the treatment of malaria owing to the significant content of vitamin E in our daily food. However, since α-tocopherol transfer protein (α-TTP) has been shown to be a determinant of vitamin E level in circulation, manipulation of α-tocopherol levels by α-TTP inhibition was considered as a potential therapeutic strategy for malaria. Knockout studies in mice indicated that inhibition of α-TTP confers resistance against malaria infections in murines, accompanied by oxidative stress-induced DNA damage in the parasite, arising from vitamin E deficiency. Read More

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http://dx.doi.org/10.3390/ijms20010064DOI Listing
December 2018

[Vitamin status of adult population of the Russian Federation: 1987-2017].

Vopr Pitan 2018 13;87(4):62-68. Epub 2018 Jul 13.

Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow.

In a review in order to characterize the dynamics of vitamin status for the period from 1987 to the present, the results of 16 surveys (conducted in 2015-2017) of the sufficiency with vitamins C, A, E, B2 and B6 of adult men and women of working age (about 1200 people) living in different regions of the Russian Federation, were compared with the frequency of vitamin insufficiency among the population in the previous period. The statistically significant improvement in the population's supply with vitamin C in the previous decade continued in 2015-2017. The deficit of this vitamin practically ceased to occur. Read More

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http://dx.doi.org/10.24411/0042-8833-2018-10043DOI Listing

Vitamin E deficiency in South Asian population and the therapeutic use of alpha-tocopherol (Vitamin E) for correction of anemia.

Pak J Med Sci 2018 Nov-Dec;34(6):1571-1575

Prof. Dr. Mohammad Perwaiz Iqbal, PhD. Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan.

Mild to moderate vitamin E deficiency because of inadequate consumption of vitamin E-rich foods and intestinal fat malabsorption is common in growing children, women of reproductive age and elderly South Asian population. Severe vitamin E deficiency may lead to peripheral and motor neurodegenerative diseases (e.g ataxia and motor skeletal myopathy), impaired immune response and free radical-induced hemolytic anemias. Read More

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http://pjms.com.pk/index.php/pjms/article/view/15880
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http://dx.doi.org/10.12669/pjms.346.15880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290196PMC
December 2018
4 Reads

Vitamin E - The Next 100 Years.

IUBMB Life 2018 Dec 14. Epub 2018 Dec 14.

Vascular Biology Laboratory, JM USDA-HNRCA at Tufts University, Boston, Massachusetts.

α-Tocopherol is the only tocopherol that has been shown to prevent the human deficiency disease Ataxia with Isolated Vitamin E Deficiency (AVED), and thus it is the only one that, for humans, can be called vitamin E. Vitamin E in addition to preventing AVED has documented immune boosting properties and an activity against nonalcoholic hepatosteatosis and low-grade inflammation. Epidemiological studies indicating that vitamin E could prevent cardiovascular events, neurodegenerative disease, macular degeneration, and cancer were in general not confirmed by clinical intervention studies. Read More

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http://dx.doi.org/10.1002/iub.1990DOI Listing
December 2018
1 Read

Regulatory role of vitamin E in the immune system and inflammation.

IUBMB Life 2018 Nov 30. Epub 2018 Nov 30.

Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, 02111, USA.

Vitamin E, a potent lipid-soluble antioxidant, found in higher concentration in immune cells compared to other cells in blood, is one of the most effective nutrients known to modulate immune function. Vitamin E deficiency has been demonstrated to impair normal functions of the immune system in animals and humans, which can be corrected by vitamin E repletion. Although deficiency is rare, vitamin E supplementation above current dietary recommendations has been shown to enhance the function of the immune system and reduce risk of infection, particularly in older individuals. Read More

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http://doi.wiley.com/10.1002/iub.1976
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http://dx.doi.org/10.1002/iub.1976DOI Listing
November 2018
6 Reads

Avian selenogenome: response to dietary Se and vitamin E deficiency and supplementation.

Poult Sci 2018 Oct 27. Epub 2018 Oct 27.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing 100083, China.

Selenium (Se) is an essential nutrient for humans and all food-producing animal species. Nutritional deficiencies of Se and (or) vitamin E induce exudative diathesis, nutritional pancreatic atrophy, and nutritional muscular dystrophy in chicks. Although these diseases are presumably associated with the need of Se for the synthesis of the 21st amino acid, selenocysteine (Sec, U) in selenoproteins, metabolic functions of the 25 selenoproteins identified in avian species remain largely unknown. Read More

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http://dx.doi.org/10.3382/ps/pey408DOI Listing
October 2018
3 Reads

Thalassemia, cholangiocarcinoma, and Vitamin E deficiency: A scenario in endemic area inSoutheast Asia.

J Cancer Res Ther 2018 Jul-Sep;14(5):1164-1165

Department of Tropical Medicine, Hainan Medical University, Hainan, China.

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http://dx.doi.org/10.4103/0973-1482.187386DOI Listing
December 2018
1 Read

Vitamin E status and its determinants in patients with cystic fibrosis.

Adv Med Sci 2018 Sep 3;63(2):341-346. Epub 2018 Aug 3.

Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznan, Poland. Electronic address:

Purpose: The risk of vitamin E deficiency is of primary concern in cystic fibrosis patients. However, early diagnosis and routine vitamin E supplementation can lead to its normal or even high levels. In the present study, we assessed vitamin E status in a large group of cystic fibrosis patients. Read More

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http://dx.doi.org/10.1016/j.advms.2018.04.001DOI Listing
September 2018
13 Reads

Exocrine Pancreatic Insufficiency and Malnutrition in Chronic Pancreatitis: Identification, Treatment, and Consequences.

Pancreas 2018 09;47(8):1015-1018

Division of Gastroenterology, and.

Objectives: The purpose of this study was to examine the impact of exocrine pancreatic insufficiency (EPI) on chronic pancreatitis (CP) patients and to identify challenges with its diagnosis and treatment.

Methods: Ninety-one patients with CP diagnosed with endoscopic ultrasound were identified and assessed for symptoms of EPI, fat-soluble vitamin levels, dual-energy x-ray absorptiometry scan T-scores, and treatment with pancreatic enzyme replacement therapy. All patients were also screened with the Malnutrition Universal Screening Test. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001137DOI Listing
September 2018
5 Reads

Efficacy of two vitamin E formulations in patients with abetalipoproteinemia and chylomicron retention disease.

J Lipid Res 2018 Sep 18;59(9):1640-1648. Epub 2018 Jul 18.

INSERM U1060, INRA UMR 1397, INSA-Lyon, CarMeN Laboratory, Université Lyon 1, Lyon, France

Abetalipoproteinemia (ABL) and chylomicron retention disease (CMRD) are extremely rare recessive forms of hypobetalipoproteinemia characterized by intestinal lipid malabsorption and severe vitamin E deficiency. Vitamin E is often supplemented in the form of fat-soluble vitamin E acetate, but fat malabsorption considerably limits correction of the deficiency. In this crossover study, we administered two different forms of vitamin E, tocofersolan (a water-soluble derivative of RRR-α-tocopherol) and α-tocopherol acetate, to three patients with ABL and four patients with CMRD. Read More

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http://dx.doi.org/10.1194/jlr.M085043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121919PMC
September 2018
13 Reads

Laboratory investigations.

Handb Clin Neurol 2018 ;154:287-298

Department of Pediatric Neurology, University Children's Hospital, University of Zurich, Zurich, Switzerland; Departments of Neurology and Ophthalmology, University Hospital Zurich, University of Zurich, Switzerland.

This chapter deals with chemical and hematologic investigations which are often considered in the diagnostic workup of subacute to chronic cerebellar ataxias. Relevant investigations in blood (serum, plasma), urine, and cerebrospinal fluid are discussed. Particular attention is paid to early diagnosis of treatable metabolic ataxias (such as abetalipoproteinemia, coenzyme Q10 deficiency, cerebrotendinous xanthomatosis, glucose transporter type 1 deficiency, Refsum disease, and vitamin E deficiency), but autoimmune ataxias, other vitamin deficiencies, and endocrine disorders should also be kept in mind. Read More

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https://linkinghub.elsevier.com/retrieve/pii/B97804446395610
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http://dx.doi.org/10.1016/B978-0-444-63956-1.00017-5DOI Listing
September 2018
6 Reads

Recessive ataxias.

Handb Clin Neurol 2018 ;155:73-89

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom; Oxford Centre for Genomic Medicine, Oxford University Hospitals NHS Trust, Oxford, United Kingdom.

Recessive ataxias (spinocerebellar ataxias, recessive or SCARs) are a heterogeneous group of rare, mostly neurodegenerative genetic disorders which usually start in childhood or early adult life. They can be subdivided into two major groups: predominant sensory or afferent ataxias, which are disorders mainly of the peripheral input to the cerebellum, and predominant cerebellar ataxias, in which the cerebellum is primarily affected. Next-generation sequencing technology has enabled the identification of >100 novel SCAR genes in the last 5 years, although most of them are ultrarare. Read More

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http://dx.doi.org/10.1016/B978-0-444-64189-2.00005-6DOI Listing
October 2018
2 Reads

Spastic ataxias.

Handb Clin Neurol 2018 ;155:191-203

Neuroscience Axis, CHU de Québec-Laval University, Quebec, QC, Canada; Neuromuscular and Neurogenetic Disease Clinic, CHU de Québec-Laval University, Quebec, QC, Canada. Electronic address:

The presence of spasticity and pyramidal features is a hallmark of some of hereditary ataxias, such as autosomal-recessive spastic ataxia of Charlevoix-Saguenay, other primary spastic ataxias, Friedreich ataxia, or ataxia with isolated vitamin E deficiency. Certain spastic paraplegias, such as spastic paraplegia 7, may present as an ataxic phenotype and often share common pathophysiologic pathways with cerebellar ataxias. Because of the rarity and genetic heterogeneity of these conditions, their molecular diagnosis remains challenging and time consuming. Read More

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http://dx.doi.org/10.1016/B978-0-444-64189-2.00012-3DOI Listing
October 2018
2 Reads

Pediatric Ataxia: Focus on Chronic Disorders.

Semin Pediatr Neurol 2018 04 5;25:54-64. Epub 2018 Jan 5.

Departments of Pediatrics and Neurology, The Children's Hospital of Philadelphia, Philadelphia, PA; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Evaluation of a pediatric patient presenting with ataxia can be expensive and time consuming. Acute causes tend to have a clear developmental paradigm, but chronic presentations are more likely to be secondary to a genetic disorder, either one that primarily causes ataxia or that presents ataxia as one of a multitude of symptoms. Evaluation should focus on a quick diagnosis for those that have treatment options and for those that require other systemic monitoring. Read More

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http://dx.doi.org/10.1016/j.spen.2018.01.001DOI Listing
April 2018
2 Reads

Current and Promising Therapies in Autosomal Recessive Ataxias.

CNS Neurol Disord Drug Targets 2018 ;17(3):161-171

Department of Medicine, Faculty of Medicine, Laval University and CHU de Quebec-Laval University, Axe Neurosciences, 1401, 18th Street, Quebec, QC, Canada.

Background & Objective: Ataxia is clinically characterized by unsteady gait and imbalance. Cerebellar disorders may arise from many causes such as metabolic diseases, stroke or genetic mutations. The genetic causes are classified by mode of inheritance and include autosomal dominant, X-linked and autosomal recessive ataxias. Read More

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http://dx.doi.org/10.2174/1871527317666180419115029DOI Listing
January 2018
4 Reads

Fat soluble vitamin levels in children with newly diagnosed celiac disease, a case control study.

BMC Pediatr 2018 04 9;18(1):130. Epub 2018 Apr 9.

Department of Biochemistry, Adnan Menderes University Medical Faculty, Aydın, Turkey.

Background: In children diagnosed with celiac disease, fat soluble vitamin levels were aimed to be evaluated and it was intended to determine whether fat soluble vitamin levels were needed to be assessed routinely in these patients during diagnosis.

Methods: Between May 2015-May 2016, diagnosis symptoms of celiac patients (CD) in newly diagnosed pediatric group were questioned, fat soluble vitamin levels simultaneous with intestinal biopsies were evaluated. Vitamin levels were compared with those of healthy control group. Read More

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http://dx.doi.org/10.1186/s12887-018-1107-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890346PMC
April 2018
3 Reads

Regulation and function of avian selenogenome.

Biochim Biophys Acta Gen Subj 2018 Apr 5. Epub 2018 Apr 5.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing 100083, China; Department of Animal Science, Cornell University, Ithaca, NY 14853, USA. Electronic address:

Background: Selenium (Se) is an essential micronutrient required by avian species. Dietary Se/vitamin E deficiency induces three classical diseases in chicks: exudative diathesis, nutritional pancreatic atrophy, and nutritional muscular dystrophy.

Scope Of Review: This review is to summarize and analyze the evolution, regulation, and function of avian selenogenome and selenoproteome and their relationship with the three classical Se/vitamin E deficiency diseases. Read More

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http://dx.doi.org/10.1016/j.bbagen.2018.03.029DOI Listing
April 2018
4 Reads

Prevalence of fat-soluble vitamin (A, D, and E) and zinc deficiency in patients with cirrhosis being assessed for liver transplantation.

Acta Gastroenterol Belg 2017 Apr-Jun;80(2):237-241

Department of Medicine, Division of Gastroenterology and Hepatology, Western University and London Health Sciences Centre, London, Ontario, Canada.

Purpose: To evaluate the prevalence of fat-soluble vitamin (A, D, and E) and zinc deficiency in patients with cirrhosis being assessed for liver transplantation and the correlations between vitamin deficiencies, nutritional markers, and severity of liver disease.

Methods: This is a single centre retrospective study. Serum vitamin A, D, E, and zinc levels were collected in adult patients being assessed for liver transplantation between January and July 2012. Read More

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April 2018
5 Reads

Update on Vitamin E and Its Potential Role in Preventing or Treating Bronchopulmonary Dysplasia.

Neonatology 2018 7;113(4):366-378. Epub 2018 Mar 7.

Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Vitamin E is obtained only through the diet and has a number of important biological activities, including functioning as an antioxidant. Evidence that free radicals may contribute to pathological processes such as bronchopulmonary dysplasia (BPD), a disease of prematurity associated with increased lung injury, inflammation and oxidative stress, led to trials of the antioxidant vitamin E (α-tocopherol) to prevent BPD with variable results. These trials were all conducted at supraphysiologic doses and 2 of these trials utilized a formulation containing a potentially harmful excipient. Read More

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http://dx.doi.org/10.1159/000487388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980725PMC
March 2018
3 Reads

Water-Soluble Vitamin E-Tocopheryl Phosphate.

Authors:
Jean-Marc Zingg

Adv Food Nutr Res 2018;83:311-363. Epub 2018 Feb 12.

Miller School of Medicine, University of Miami, Miami, FL, United States. Electronic address:

The hydrophobicity of vitamin E poses transport and metabolic challenges to regulate its bioavailability and to prevent its accumulation in lipid-rich tissues such as adipose tissue, brain, and liver. Water-soluble precursors of vitamin E (α-tocopherol, αT), such as its esters with acetate (αTA), succinate (αTS), or phosphate (αTP), have increased solubility in water and stability against reaction with free radicals, but they are rapidly converted during their uptake into the lipid-soluble vitamin E. Therefore, the bioavailability of these precursors as intact molecules is low; nevertheless, at least for αTS and αTP, the recent research has revealed unique regulatory effects on signal transduction and gene expression and the modulation of cellular events ranging from proliferation, survival/apoptosis, lipid uptake and metabolism, phagocytosis, long term potentiation, cell migration, telomere maintenance, and angiogenesis. Read More

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http://dx.doi.org/10.1016/bs.afnr.2017.12.007DOI Listing
May 2018
3 Reads

Vitamin E Status Is Inversely Associated with Risk of Incident Tuberculosis Disease among Household Contacts.

J Nutr 2018 01;148(1):56-62

Department of Global Health and Social Medicine, and Division of Global Health Equity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Background: Few studies have previously assessed how pre-existing vitamin E status is associated with risk of tuberculosis (TB) disease progression.

Objective: We evaluated the association between baseline plasma concentrations of 3 vitamin E isomers (α-tocopherol, γ-tocopherol, and δ-tocopherol) and TB disease risk.

Methods: We conducted a case-control study nested within a longitudinal cohort of household contacts (HHCs) of pulmonary TB cases in Lima, Peru. Read More

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http://dx.doi.org/10.1093/jn/nxx006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251539PMC
January 2018
3 Reads

Case 35-2017. A 57-Year-Old Woman with Hypoesthesia and Weakness in the Legs and Arms.

N Engl J Med 2017 11;377(20):1977-1984

From the Departments of Neurology (M.P.B., W.S.D., T.A.C.) and Pathology (A.S.D.), Massachusetts General Hospital, and the Departments of Neurology (M.P.B., W.S.D., T.A.C.) and Pathology (A.S.D.), Harvard Medical School - both in Boston.

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http://dx.doi.org/10.1056/NEJMcpc1710564DOI Listing
November 2017
19 Reads

Hepatic accumulation of S-Adenosylmethionine in hamsters with non-alcoholic-fatty liver disease associated to metabolic syndrome under selenium and vitamin E deficiency.

Clin Sci (Lond) 2017 Nov 9. Epub 2017 Nov 9.

EURECAT, Reus, Spain.

Progression of non-alcoholic fatty liver disease (NAFLD) in the context of metabolic syndrome (MetS) is only partially explored due to the lack of preclinical models. In order to study the alterations in hepatic metabolism that accompany this condition, we developed a model of MetS accompanied by the onset of steatohepatitis (NASH) by challenging golden hamsters with a high fat diet low in vitamin E and selenium (HFD), since combined deficiency results in hepatic necroinflammation in rodents. Metabolomics and transcriptomics integrated analyses of livers revealed an unexpected accumulation of hepatic S-Adenosylmethionine (SAM) when compared with healthy livers likely due to diminished methylation reactions and repression of GNMT. Read More

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http://dx.doi.org/10.1042/CS20171039DOI Listing
November 2017
8 Reads

Diagnosis of multiple system atrophy.

Auton Neurosci 2018 May 23;211:15-25. Epub 2017 Oct 23.

Department of Neurology, Dysautonomia Center, New York University School of Medicine, NY, USA. Electronic address:

Multiple system atrophy (MSA) may be difficult to distinguish clinically from other disorders, particularly in the early stages of the disease. An autonomic-only presentation can be indistinguishable from pure autonomic failure. Patients presenting with parkinsonism may be misdiagnosed as having Parkinson disease. Read More

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http://dx.doi.org/10.1016/j.autneu.2017.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869112PMC
May 2018
11 Reads

Vitamin E in the Preterm Infant: A Forgotten Cause of Hemolytic Anemia.

Am J Perinatol 2018 Feb 10;35(3):305-310. Epub 2017 Oct 10.

Division of Neonatology, Department of Pediatrics, University of Kentucky, Lexington, Kentucky.

Objective:  Vitamin E deficiency in premature infants has been associated with hemolytic anemia. Its incidence decreased after the supplementation of preterm formulas and parenteral nutrition with vitamin E. Despite this, some infants still develop hemolytic anemia and receive vitamin E. Read More

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http://dx.doi.org/10.1055/s-0037-1607283DOI Listing
February 2018
11 Reads

Epidemiology of Cerebellar Diseases and Therapeutic Approaches.

Authors:
Michael S Salman

Cerebellum 2018 02;17(1):4-11

Section of Pediatric Neurology, Children's Hospital, AE 308, 820 Sherbrook Street, Winnipeg, MB, R3A 1R9, Canada.

Diseases involving the cerebellum occur relatively commonly in children and adults around the globe. Many factors influence their epidemiology including geography, ethnicity, consanguinity, and the methodology used to ascertain patients. In addition, reliable epidemiological data rely heavily on accurate disease classification. Read More

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http://dx.doi.org/10.1007/s12311-017-0885-2DOI Listing
February 2018
5 Reads

Vitamin E Deficiency and Oxidative Status are Associated with Prediabetes in Apparently Healthy Subjects.

Arch Med Res 2017 Apr;48(3):257-262

Facultad de Medicina y Nutrición, Universidad Juárez del Estado de Durango, Durango, Dgo., México.

Background: Previous studies have indicated that vitamin E deficiency and oxidative stress affect the beta cell function. Hence, the aim of this study was to determine the association between vitamin E deficiency and oxidative status with prediabetes in apparently healthy subjects.

Methods: Apparently healthy men and women aged 18-65 years were enrolled in a case-control study. Read More

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http://dx.doi.org/10.1016/j.arcmed.2017.03.018DOI Listing
April 2017
5 Reads

Defense-Related Transcriptional Reprogramming in Vitamin E-Deficient Arabidopsis Mutants Exposed to Contrasting Phosphate Availability.

Front Plant Sci 2017 10;8:1396. Epub 2017 Aug 10.

Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, University of BarcelonaBarcelona, Spain.

Vitamin E inhibits the propagation of lipid peroxidation and helps protecting photosystem II from photoinhibition, but little is known about its possible role in plant response to Pi availability. Here, we aimed at examining the effect of vitamin E deficiency in mutants on phytohormone contents and the expression of transcription factors in plants exposed to contrasting Pi availability. Plants were subjected to two doses of Pi, either unprimed (controls) or previously exposed to low Pi (primed). Read More

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http://dx.doi.org/10.3389/fpls.2017.01396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554346PMC
August 2017
3 Reads

Chronic vitamin E deficiency impairs cognitive function in adult zebrafish via dysregulation of brain lipids and energy metabolism.

Free Radic Biol Med 2017 11 5;112:308-317. Epub 2017 Aug 5.

Linus Pauling Institute, Oregon State University, Corvallis, OR 97330, USA; College of Public Health and Human Sciences, Oregon State University, Corvallis, OR 97330, USA. Electronic address:

Zebrafish (Danio rerio) are a recognized model for studying the pathogenesis of cognitive deficits and the mechanisms underlying behavioral impairments, including the consequences of increased oxidative stress within the brain. The lipophilic antioxidant vitamin E (α-tocopherol; VitE) has an established role in neurological health and cognitive function, but the biological rationale for this action remains unknown. In the present study, we investigated behavioral perturbations due to chronic VitE deficiency in adult zebrafish fed from 45 days to 18-months of age diets that were either VitE-deficient (E-) or VitE-sufficient (E+). Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2017.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629005PMC
November 2017
30 Reads

Thyroid function of steatitis-affected Mozambique tilapia Oreochromis mossambicus from a sub-tropical African reservoir.

Dis Aquat Organ 2017 07;125(2):101-113

Sustainability Research Unit, Nelson Mandela Metropolitan University, Private Bag x6531, George 6530, South Africa.

Thyroid function and nutritional indicators were measured in obese, steatitis-affected Mozambique tilapia Oreochromis mossambicus from Loskop Reservoir (LR), South Africa. Plasma thyroid hormones (especially T3) and thyroid follicle histomorphology revealed high levels of activity in every aspect of the thyroid cascade measured in fish from LR compared to a reference population of steatitis-free fish. Concurrent measurements of nutritional state including plasma lipids, liver lipid content and hepatocyte size showed that fish from LR had significant energy stores indicative of abundant nutritional intake. Read More

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http://dx.doi.org/10.3354/dao03138DOI Listing
July 2017
5 Reads

Ataxia in children: think about vitamin E deficiency ! (comment on: ataxia in children: early recognition and clinical evaluation).

Ital J Pediatr 2017 Jul 19;43(1):62. Epub 2017 Jul 19.

Pediatrics Department, Setif University Hospital, Genetic & Nutritional Diseases Laboratory, Setif-1 University, 19000, Setif, Algeria.

A recent article from Pavone et al. published in the Italian Journal of Pediatrics entitled «Ataxia in children: early recognition and clinical evaluation» made an exhaustive overview of the large spectrum of pediatric ataxias. However, we would underline the importance of considering hereditary ataxia due to isolated vitamin E deficiency as a specific and treatable cause of child ataxia. Read More

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http://dx.doi.org/10.1186/s13052-017-0378-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517814PMC
July 2017
6 Reads
1.236 Impact Factor

The risk of plasma vitamin A, C, E and D deficiency in patients with metabolic syndrome: A case-control study.

Adv Clin Exp Med 2017 Jul;26(4):581-586

Department of Internal and Infectious Diseases, Medical University of Łódz, Poland.

Background: The increasing incidence of metabolic diseases such as obesity or diabetes have made them a major public health problem. Increasing oxidative stress induced by reactive oxygen species, which initiate the oxidative adverse changes in the cell, is mentioned, among other risk factors, to underlie these diseases. Vitamin A, C and E are listed among the non-enzymatic mechanisms counteracting this phenomenon. Read More

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http://dx.doi.org/10.17219/acem/62453DOI Listing
July 2017
40 Reads

Vitamin E deficiency during embryogenesis in zebrafish causes lasting metabolic and cognitive impairments despite refeeding adequate diets.

Free Radic Biol Med 2017 09 20;110:250-260. Epub 2017 Jun 20.

Linus Pauling Institute, Oregon State University, Corvallis, OR 97330, USA; College of Public Health and Human Sciences, Oregon State University, Corvallis, OR 97330, USA. Electronic address:

Vitamin E (α-tocopherol; VitE) is a lipophilic antioxidant required for normal embryonic development in vertebrates, but the long-term effects of embryonic VitE deficiency, and whether they are ameliorated by feeding VitE-adequate diets, remain unknown. We addressed these questions using a zebrafish (Danio rerio) model of developmental VitE deficiency followed by dietary remediation. Adult zebrafish maintained on VitE-deficient (E-) or sufficient (E+) diets were spawned to obtained E- and E+ embryos, respectively, which we evaluated up to 12 days post-fertilization (dpf). Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2017.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548191PMC
September 2017
13 Reads

Severe but reversible neuropathy and encephalopathy due to vitamin E deficiency.

Clin Neurol Neurosurg 2017 Sep 8;160:19-20. Epub 2017 Jun 8.

Queen Elizabeth Hospital, University Hospitals of Birmingham, Birmingham, UK; School of Life and Health Sciences, Aston Brain Centre, Aston University, Birmingham, UK. Electronic address:

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http://dx.doi.org/10.1016/j.clineuro.2017.06.005DOI Listing
September 2017
9 Reads

Many tocopherols, one vitamin E.

Authors:
Angelo Azzi

Mol Aspects Med 2018 Jun 19;61:92-103. Epub 2017 Jun 19.

Vascular Biology Laboratory, JM USDA-HNRCA at Tufts University, Boston, MA 02111, USA. Electronic address:

Four tocopherols are available in nature and are absorbed with the diet, but only one RRR-α-tocopherol satisfies the criteria of being a vitamin. The biological activity of the different tocopherols studied in the rat by the resorption-gestation test has been inconsistently extrapolated to human beings where the tocopherols have no influence on a successful pregnancy. Diminution of RRR-α-tocopherol intake results in diseases characterized by ataxia, whose pathogenetic mechanism, despite vigorous claims, has not been clarified. Read More

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http://dx.doi.org/10.1016/j.mam.2017.06.004DOI Listing
June 2018
1 Read

Effect of RRR-α-tocopherol supplementation on serum of breastfeeding women up to 60 days after delivery: a randomised controlled trial.

J Hum Nutr Diet 2017 Dec 23;30(6):771-778. Epub 2017 May 23.

Department of Biochemistry, Federal University of Rio Grande do Norte, Natal, RN, Brazil.

Background: Maternal supplementation is a viable strategy to combat vitamin E deficiency in newborns, although a protocol for maternal vitamin E supplementation has not been defined. The present study assessed the effect of maternal supplementation in a single dose on the serum of postpartum women up to 60 days after delivery.

Methodology: Fifty healthy breastfeeding women were recruited at two maternity hospitals both located in Natal, RN, Brazil. Read More

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http://dx.doi.org/10.1111/jhn.12482DOI Listing
December 2017
2 Reads

Pansteatitis in polluted Olifants River impoundments: nutritional perspectives on fish in a eutrophic lake, Lake Loskop, South Africa.

J Fish Dis 2017 Nov 11;40(11):1665-1680. Epub 2017 May 11.

Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa.

This study compares the aetiology of pansteatitis in Lake Loskop, relative to two other impoundments along the Olifants River. Macroscopic and microscopic pathology, age determination and analysis of stomach content, fatty acids and stable isotopes explain the high prevalence of pansteatitis in Oreochromis mossambicus (Peters) and several other species in Lake Loskop. All the dietary indicator comparisons between pansteatitis-affected and healthy fish fail to support a systemic cause. Read More

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http://dx.doi.org/10.1111/jfd.12633DOI Listing
November 2017
8 Reads

Effects of feeding two RRR-α-tocopherol formulations on serum, cerebrospinal fluid and muscle α-tocopherol concentrations in horses with subclinical vitamin E deficiency.

Equine Vet J 2017 Nov 25;49(6):753-758. Epub 2017 May 25.

Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, California, USA.

Background: Alpha-tocopherol (α-TP) supplementation is recommended for the prevention of various equine neuromuscular disorders. Formulations available include RRR-α-TP acetate powder and a more expensive but rapidly water-dispersible liquid RRR-α-TP (WD RRR-α-TP). No cost-effective means of rapidly increasing serum and cerebrospinal fluid (CSF) α-TP with WD RRR-α-TP and then sustaining concentrations with RRR-α-TP acetate has yet been reported. Read More

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http://doi.wiley.com/10.1111/evj.12692
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http://dx.doi.org/10.1111/evj.12692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640495PMC
November 2017
15 Reads

The Inhibitory Effect of Nodakenin on Mast-Cell-Mediated Allergic Inflammation Via Downregulation of NF-κB and Caspase-1 Activation.

J Cell Biochem 2017 11 30;118(11):3993-4001. Epub 2017 May 30.

Department of Pharmacology, College of Korean Medicine, Sangji University, Gangwon-do 220-702, Republic of Korea.

Nodakenin, a coumarin isolated from the roots of Angelicae gigas, is effective for treating function control disorders, bacterial infections, pain, diarrhea, vitamin E deficiency, and for relaxation of the uterus. The aim of this study was to investigate the antiallergic related inflammatory effects in phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated human mast cells (HMC-1) or anaphylactic activity in a mouse model. Nodakenin inhibited the mRNA expression and production of pro-inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β in PMACI-stimulated HMC-1. Read More

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http://doi.wiley.com/10.1002/jcb.26055
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http://dx.doi.org/10.1002/jcb.26055DOI Listing
November 2017
17 Reads

Vitamin E-coated dialysis membranes reduce the levels of oxidative genetic damage in hemodialysis patients.

Mutat Res 2017 03 3;815:16-21. Epub 2017 Feb 3.

Fundació Puigvert, Barcelona, Spain. Electronic address:

End-stage renal disease patients present oxidative stress status that increases when they are submitted to hemodialysis (HD). This increase in oxidative stress can affect their genetic material, among other targets. The objective of this study was to evaluate the effect of using polysulfone membranes coated with vitamin E, during the HD sessions, on the levels of genetic damage of HD patients. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2017.01.003DOI Listing
March 2017
2 Reads

Vitamin E supplementation in people with cystic fibrosis.

Cochrane Database Syst Rev 2017 03 6;3:CD009422. Epub 2017 Mar 6.

West Midlands Adult Cystic Fibrosis Centre, Heart of England NHS Foundation Trust, Bordesley Green East, Birmingham, UK, B9 5SS.

Background: People with cystic fibrosis are at an increased risk of fat-soluble vitamin deficiency including vitamin E. Vitamin E deficiency can cause a host of conditions such as haemolytic anaemia, cerebellar ataxia and cognitive difficulties. Vitamin E supplementation is widely recommended in cystic fibrosis and aims to ameliorate this deficiency. Read More

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http://dx.doi.org/10.1002/14651858.CD009422.pub3DOI Listing
March 2017
14 Reads

Histomorphology, ultrastructure and fatty acid composition of the adipose tissue in pansteatitis, the potentials in understanding the underlying mechanism and diagnosis of pansteatitis in the Nile crocodile.

Lipids Health Dis 2017 Feb 23;16(1):47. Epub 2017 Feb 23.

Anatomy and Physiology Department, Faculty of Veterinary Science, University of Pretoria, Onderstepoort 0110, Pretoria, South Africa.

Background: In an effort to characterize the fat body and other adipose tissue in the Nile crocodile and the effects of pansteatitis on the structure and composition of the adipose tissue, we evaluated the regional variation in structure and fatty acid composition of healthy farmed crocodiles and those affected by pansteatitis.

Methods: Adipose tissue samples were collected from the subcutaneous, visceral and intramuscular fat and the abdominal fat body of ten 4-year old juvenile crocodiles from Izinthaba Crocodile Farm, Pretoria, South Africa while pansteatitis samples were collected from visceral and intramuscular fat of crocodiles that had died of pansteatitis at the Olifant River, Mpumalanga, also in South Africa. Histomorphology, ultrastrustucture and fatty acid composition by fatty acid methyl ester (FAME) analysis were conducted. Read More

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http://lipidworld.biomedcentral.com/articles/10.1186/s12944-
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http://dx.doi.org/10.1186/s12944-016-0405-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324266PMC
February 2017
3 Reads

The dietary protein paradox and threonine N-depletion: Pyridoxal-5'-phosphate enzyme activity as a mechanism for the δ N trophic level effect.

Rapid Commun Mass Spectrom 2017 Apr;31(8):705-718

Department of Physiology of Energy Metabolism, German Institute of Human Nutrition in Potsdam-Rehbruecke (DIfE), Arthur-Scheunert-Allee 114-116, D-14558, Nuthetal, Germany.

Rationale: Nitrogen stable isotope ratios (δ N values) are used to reconstruct dietary patterns, but the biochemical mechanism(s) responsible for the diet to tissue trophic level effect and its variability are not fully understood. Here δ N amino acid (AA) values and physiological measurements (nitrogen intake, plasma albumin concentrations, liver-reduced glutathione concentrations and leucine oxidation rates) are used to investigate increased dietary protein consumption and oxidative stress (vitamin E deficiency) in rat total plasma protein.

Methods: Using gas chromatography/combustion/isotope ratio mass spectrometry, the δ N values from N-pivaloyl-i-propyl esters of 15 AAs are reported for rats (n = 40) fed casein-based diets with: adequate protein (AP, 13. Read More

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http://dx.doi.org/10.1002/rcm.7835DOI Listing
April 2017
39 Reads

50 Years Ago in The Journal of Pediatrics: Vitamin E Deficiency: A Previously Unrecognized Cause of Hemolytic Anemia in the Premature Infant.

J Pediatr 2017 02;181:162

Division of Gastroenterology, Hepatology, and Nutrition Boston Children's Hospital Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.jpeds.2016.08.091DOI Listing
February 2017
5 Reads

Liver Transplantation as a Treatment for Severe Refractory Vitamin E Deficiency Related to Progressive Familial Intrahepatic Cholestasis Type 2 in a Pediatric Patient.

ACG Case Rep J 2016 Aug 21;3(4):e193. Epub 2016 Dec 21.

Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic Children's Hospital, Cleveland, OH.

Refractory vitamin E deficiency is thought to have irreversible effects on neurologic function. We report an adolescent boy with severe refractory vitamin E deficiency due to progressive familial intrahepatic cholestasis (PFIC) type 2. His consequent neurologic dysfunction included severe ataxia, dysmetria, dysarthria, and cranial nerve VI palsy. Read More

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http://acgcasereports.gi.org/liver-transplantation-as-a-trea
Publisher Site
http://dx.doi.org/10.14309/crj.2016.166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226191PMC
August 2016
3 Reads

Lethal dysregulation of energy metabolism during embryonic vitamin E deficiency.

Free Radic Biol Med 2017 03 14;104:324-332. Epub 2017 Jan 14.

Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA; College of Public Health and Human Sciences, Oregon State University, Corvallis, OR 97331, USA; Environmental Health Sciences Center, Oregon State University, Corvallis, OR 97331, USA. Electronic address:

Vitamin E (α-tocopherol, VitE) was discovered in 1922 for its role in preventing embryonic mortality. We investigated the underlying mechanisms causing lethality using targeted metabolomics analyses of zebrafish VitE-deficient embryos over five days of development, which coincided with their increased morbidity and mortality. VitE deficiency resulted in peroxidation of docosahexaenoic acid (DHA), depleting DHA-containing phospholipids, especially phosphatidylcholine, which also caused choline depletion. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08915849173002
Publisher Site
http://dx.doi.org/10.1016/j.freeradbiomed.2017.01.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344700PMC
March 2017
5 Reads