4,000 results match your criteria Vitamin E Deficiency


Effects of vitamin E on neurodegenerative diseases: an update.

Acta Neurobiol Exp (Wars) 2021 ;81(1):21-33

Gazi University , Faculty of Health Sciences , Nutrition and Dietetics Department , Ankara , Turkey.

Vitamin E deficiency is associated with many neurological problems. Although the mechanisms of vitamin E action in neurodegenerative diseases are not clear, there are many possible mechanisms. Examples of such mechanisms are the protective effects of vitamin E against oxidative stress damage and its suppressive role in the expression of many genes involved in the development of neurodegeneration. Read More

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January 2021

Sensory Axonopathy Associated With Vitamin E Deficiency.

Cureus 2021 Feb 17;13(2):e13389. Epub 2021 Feb 17.

Infectious Diseases, Saint Michael's Medical Center, Newark, USA.

Vitamin E deficiency can be observed in patients with malabsorption syndromes or inherited diseases such as ataxia. It is unusual for it to be a result of dietary insufficiency due to its presence in a wide variety of foods. Patients with vitamin E deficiency can present with neuromuscular disorders such as ataxia, hyporeflexia, spinocerebellar syndrome, as well as loss of vibration and proprioceptive sensation. Read More

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February 2021

[A cachectic man with a severe vitamin deficiency].

Ned Tijdschr Geneeskd 2021 03 11;165. Epub 2021 Mar 11.

Erasmus MC, afd. Heelkunde, Rotterdam.

A 57-year-old man, known with severe malnutrition, vitamin E deficiency and peripheral neuropathies, presented with vomiting and abdominal tenderness. There was a suspicion of ileus and small bowel obstruction. During the exploratory laparotomy a complete brown colored bowel without peristalsis was seen. Read More

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Vitamin E Deficiency Disrupts Gene Expression Networks during Zebrafish Development.

Nutrients 2021 Jan 30;13(2). Epub 2021 Jan 30.

Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA.

Vitamin E (VitE) is essential for vertebrate embryogenesis, but the mechanisms involved remain unknown. To study embryonic development, we fed zebrafish adults (>55 days) either VitE sufficient (E+) or deficient (E-) diets for >80 days, then the fish were spawned to generate E+ and E- embryos. To evaluate the transcriptional basis of the metabolic and phenotypic outcomes, E+ and E- embryos at 12, 18 and 24 h post-fertilization (hpf) were subjected to gene expression profiling by RNASeq. Read More

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January 2021

Hidden Hunger of Vitamin E Among Healthy College Students: A CrossSectional Study.

Endocr Metab Immune Disord Drug Targets 2021 Jan 1. Epub 2021 Jan 1.

Department of Nutrition and Food Hygiene, School of Public health, Nanjing Medical University, Nanjing. China.

Background: College students may have risk of fat-soluble vitamins deficiencies due to unhealthy dietary habits, especially for vitamin A and E. They are important members in the human antioxidant network, deficiencies of these vitamins may increase risk of many critical diseases.

Objective: The current study was undertaken to determine the status of vitamin A and E in college students. Read More

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January 2021

Vitamin E status among bariatric surgery patients: a systematic review.

Surg Obes Relat Dis 2021 Apr 10;17(4):816-830. Epub 2020 Nov 10.

School of Nutritional Sciences, The Hebrew University of Jerusalem, Rehovot, Israel; Israel Center for Disease Control, Ministry of Health, Ramat Gan, Israel. Electronic address:

Vitamin E, a fat-soluble vitamin with antioxidant properties, is thought to modulate enzymes involved in signal transduction, affect gene expression, and have immunomodulatory capabilities. Severe vitamin E deficiency is associated with neuronal disorders, impaired immune response, hemolytic anemia, and oxidative-based disorders. Patients who undergo bariatric surgery (BS), especially malabsorptive procedures, are at greater risk of developing fat-soluble vitamin deficiencies. Read More

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Associations Between Antioxidant Vitamin Status, Dietary Intake, and Retinol-Binding Protein 4 Levels in Prepubertal Obese Children After 3-Month Weight Loss Therapy.

J Clin Res Pediatr Endocrinol 2020 Dec 2. Epub 2020 Dec 2.

Department of Screening Tests and Metabolic Diagnostics, Institute of Mother and Child, 01-211 Warsaw, Poland.

Objective: Adiposity is associated with increased oxidative stress, leading to changed fat-soluble vitamin concentrations. The aim of this study was to determine whether weight loss alters fat-soluble vitamin status and whether these alterations are associated with dietary intake, anthropometric parameters and adipokines in obese children.

Methods: Vitamin A and E concentrations were measured using high-pressure liquid chromatography in 60 obese children before and after weight loss therapy. Read More

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December 2020

Vitamin E deficiency dysregulates thiols, amino acids and related molecules during zebrafish embryogenesis.

Redox Biol 2021 01 4;38:101784. Epub 2020 Nov 4.

Linus Pauling Institute, Oregon State University, Corvallis, OR, USA; School of Biological and Population Health Sciences, College of Public Health, Oregon State University, Corvallis, OR, USA. Electronic address:

Vitamin E (α-tocopherol, VitE) was discovered as a nutrient essential to protect fetuses, but its molecular role in embryogenesis remains undefined. We hypothesize that the increased lipid peroxidation due to VitE deficiency drives a complex mechanism of overlapping biochemical pathways needed to maintain glutathione (GSH) homeostasis that is dependent on betaine and its methyl group donation. We assess amino acids and thiol changes that occur during embryogenesis [12, 24 and 48 h post fertilization (hpf)] in VitE-sufficient (E+) and deficient (E-) embryos using two separate, novel protocols to quantitate changes using UPLC-MS/MS. Read More

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January 2021

Ophthalmologic evaluation in vitamin-E deficiency: A case report.

Eur J Ophthalmol 2020 Nov 3:1120672120970112. Epub 2020 Nov 3.

Eye Clinic of Genoa, Policlinico San Martino, Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy.

A 41-year-old woman has come to our attention complaining of decreased visual acuity and monocular diplopia associated with upper and lower limb hypoesthesia. Malabsorption syndrome with vitamin A and E deficiency developed after a bariatric biliopancreatic diversion. The clinical ophthalmological signs and symptoms improved after oral vitamin supplementation therapy. Read More

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November 2020

Effect of Fat-Soluble Vitamins A, D, E and K on Vitamin Status and Metabolic Profile in Patients with Fat Malabsorption with and without Urolithiasis.

Nutrients 2020 Oct 12;12(10). Epub 2020 Oct 12.

Bonn Education Association for Dietetics r. A., 50935 Cologne, Germany.

Patients with intestinal fat malabsorption and urolithiasis are particularly at risk of acquiring fat-soluble vitamin deficiencies. The aim of the study was to evaluate the vitamin status and metabolic profile before and after the supplementation of fat-soluble vitamins A, D, E and K (ADEK) in 51 patients with fat malabsorption due to different intestinal diseases both with and without urolithiasis. Anthropometric, clinical, blood and 24-h urinary parameters and dietary intake were assessed at baseline and after ADEK supplementation for two weeks. Read More

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October 2020

Clinical Therapeutic Management of Human Mitochondrial Disorders.

Authors:
Josef Finsterer

Pediatr Neurol 2020 12 6;113:66-74. Epub 2020 Jul 6.

Klinik Landstrasse, Messerli Institute, Vienna, Austria. Electronic address:

Despite recent advances in the elucidation of etiology and pathogenesis of mitochondrial disorders, their therapeutic management remains challenging. This review focuses on currently available therapeutic options for human mitochondrial disorders. Current treatment of mitochondrial disorders relies on symptomatic, multidisciplinary therapies of various manifestations in organs such as the brain, muscle, nerves, eyes, ears, endocrine organs, heart, intestines, kidneys, lungs, bones, bone marrow, cartilage, immune system, and skin. Read More

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December 2020

Effect of vitamin E deficiency on spermatogenesis in mice and its similarity to aging.

Reprod Toxicol 2020 12 10;98:225-232. Epub 2020 Oct 10.

Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki-Aoba, Aoba-ku, Sendai, Miyagi 980-8572, Japan. Electronic address:

Vitamin E (VE) plays numerous important roles in mammals because of its antioxidant activity. As a result, VE deficiency (VED) leads to the dysfunction of central nervous, reproductive, and immune systems. However, few studies have reported the effects of VED on the male reproductive system. Read More

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December 2020

Cardiovascular and Metabolic Protection by Vitamin E: A Matter of Treatment Strategy?

Antioxidants (Basel) 2020 Sep 29;9(10). Epub 2020 Sep 29.

Atherothrombosis and Vascular Biology Laboratory, Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC 3004, Australia.

Cardiovascular diseases (CVD) cause about 1/3 of global deaths. Therefore, new strategies for the prevention and treatment of cardiovascular events are highly sought-after. Vitamin E is known for significant antioxidative and anti-inflammatory properties, and has been studied in the prevention of CVD, supported by findings that vitamin E deficiency is associated with increased risk of cardiovascular events. Read More

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September 2020

A first description of ataxia with vitamin E deficiency associated with MT-TG gene mutation.

Acta Neurol Belg 2020 Sep 26. Epub 2020 Sep 26.

Laboratory of Molecular and Functional Genetics, Faculty of Science of Sfax, Sfax, Tunisia.

Ataxia with isolated vitamin E deficiency (AVED) is a rare autosomal recessive cerebellar ataxia disorder that is caused by a mutation in the alpha-tocopherol transfer protein gene TTPA, leading to a lower level of serum vitamin E. Although it is almost clinically similar to Friedreich's ataxia, its devastating neurological features can be prevented with appropriate treatment. In this study, we present a patient who was initially diagnosed with Friedreich's ataxia, but was later found to have AVED. Read More

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September 2020

Vitamin E is necessary for zebrafish nervous system development.

Sci Rep 2020 09 21;10(1):15028. Epub 2020 Sep 21.

Linus Pauling Institute, Oregon State University, 307 LPSC, Corvallis, OR, USA.

Vitamin E (VitE) deficiency results in embryonic lethality. Knockdown of the gene ttpa encoding for the VitE regulatory protein [α-tocopherol transfer protein (α-TTP)] in zebrafish embryos causes death within 24 h post-fertilization (hpf). To test the hypothesis that VitE, not just α-TTP, is necessary for nervous system development, adult 5D strain zebrafish, fed either VitE sufficient (E+) or deficient (E-) diets, were spawned to obtain E+ and E- embryos, which were subjected to RNA in situ hybridization and RT-qPCR. Read More

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September 2020

Pearls & Oy-sters: A Novel Presentation of Ataxia With Vitamin E Deficiency Caused by Gene Mutation.

Neurology 2021 01 14;96(4):e640-e642. Epub 2020 Sep 14.

From the Division of Neurology, Cincinnati Children's Hospital Medical Center, OH.

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January 2021

Vitamin E supplementation in people with cystic fibrosis.

Cochrane Database Syst Rev 2020 09 6;9:CD009422. Epub 2020 Sep 6.

West Midlands Adult Cystic Fibrosis Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

Background: People with cystic fibrosis are at an increased risk of fat-soluble vitamin deficiency, including vitamin E. Vitamin E deficiency can cause a host of conditions such as haemolytic anaemia, cerebellar ataxia and cognitive difficulties. Vitamin E supplementation is widely recommended for people with cystic fibrosis and aims to ameliorate this deficiency. Read More

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September 2020

Multifunctional activity of vitamin E in animal and animal products: A review.

Anim Sci J 2020 Jan-Dec;91(1):e13352

MPED Research Center, Department of Botany, University of Fort Hare, Alice, South Africa.

Vitamin E is an essential nontoxic fat-soluble micronutrient whose effects on livestock performance and products can be attributed to its antioxidant and nonantioxidant properties. Although it is needed in small quantity in the diet, its roles in livestock production are indispensable as it is required in boosting performance, nutritional qualities, and yield of animal and animal products. The dietary or oral supplementation of vitamin E is essential in reducing lipid oxidation in muscle, egg, and dairy products as well as lowering cholesterol concentrations and improving antioxidant status of livestock. Read More

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Severe chronic bowel obstruction associated with brown bowel syndrome.

SAGE Open Med Case Rep 2020 22;8:2050313X20945531. Epub 2020 Jul 22.

Department of Pathology, Loma Linda University Medical Center, Loma Linda, CA, USA.

A 61-year-old alcoholic male with history of cholecystectomy presented with a 20-year history of recurrent bowel obstruction and a 30 lb weight loss. After numerous attempts at conservative management, exploratory laparotomy was performed, which showed no mechanical cause. Despite no clear etiology, the obstruction persisted and intensified. Read More

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A histological evaluation of pansteatitis-affected Mozambique tilapia, Oreochromis mossambicus (Peters 1852), from different geographical locations in South Africa.

J Fish Dis 2020 Oct 1;43(10):1185-1199. Epub 2020 Aug 1.

Chemical Sciences Division, Hollings Marine Laboratory, National Institute of Standards and Technology, Charleston, SC, USA.

Pansteatitis is the leading cause for the decline in Nile crocodile populations and the sporadic mortality of fish in the Olifants River System, South Africa. To determine the prevalence of this disease in lentic systems, Mozambique tilapia, Oreochromis mossambicus, were collected from Lake Loskop, Lake Flag Boshielo, Phalaborwa Barrage and Lake Luphephe-Nwanedi. The former three impoundments are located within the main stem of the Olifants River, while the latter, which is geographically isolated and situated in the Limpopo River System, served as a reference site. Read More

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October 2020

Micronutrient deficits in patients with chronic pancreatitis: prevalence, risk factors and pitfalls.

Eur J Gastroenterol Hepatol 2020 10;32(10):1328-1334

Department of Clinical Medicine, Aalborg University.

Objective: We investigated the prevalence of micronutrient deficiencies and associated patient and disease-related risk factors in patients with chronic pancreatitis (CP).

Methods: We enrolled 115 consecutive CP outpatients. Micro-nutritional assessments included plasma levels of fat-soluble vitamins (A, D and E) and trace elements (magnesium and zinc). Read More

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October 2020

Complex Virome in a Mesenteric Lymph Node from a Californian Sea Lion ( with Polyserositis and Steatitis.

Viruses 2020 07 23;12(8). Epub 2020 Jul 23.

Vitalant Research Institute, 270 Masonic Ave, San Francisco, CA 94118, USA.

An emaciated subadult free-ranging California sea lion (Csl or died following stranding with lesions similar to 11 other stranded animals characterized by chronic disseminated granulomatous inflammation with necrotizing steatitis and vasculitis, involving visceral adipose tissues in the thoracic and peritoneal cavities. Histologically, affected tissues had extensive accumulations of macrophages with perivascular lymphocytes, plasma cells, and fewer neutrophils. Using viral metagenomics on a mesenteric lymph node six mammalian viruses were identified consisting of novel parvovirus, polyomavirus, rotavirus, anellovirus, and previously described Csl adenovirus 1 and Csl bocavirus 4. Read More

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First Recognized Patient with Genetic Vitamin E Deficiency Stable after 36 Years of Controlled Supplement Therapy.

Neurodegener Dis 2020 3;20(1):35-38. Epub 2020 Jul 3.

Department of Neuropediatrics, University Hospital and Faculty of Medicine Carl Gustav Carus, Dresden, Germany.

Introduction: Familial isolated deficiency of vitamin E (VED or AVED; MIM #277460) is a progressive neurodegenerative disorder resembling Friedreich ataxia. It is caused by the deficiency of α-tocopherol transfer protein that prevents patients from retaining vitamin E. Oral vitamin E supplements are an accepted treatment, but detailed dosage recommendations and reports on long-term therapeutic results are scarce. Read More

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The Relationship between Serum Vitamin E Level and Risk Factors for Arteriosclerosis in Japanese Postmenopausal Women.

J Nutr Sci Vitaminol (Tokyo) 2020 ;66(3):213-218

Department of Clinical Nutrition, Graduate School of Comprehensive Rehabilitation, Osaka Prefecture University.

Since vitamin E is one of the most potent antioxidant and anti-inflammatory agents, vitamin E can play a role against arteriosclerosis through various actions. Then, we have studied the relationship between serum vitamin E status and risk factors for arteriosclerosis in Japanese postmenopausal women. One hundred and seven subjects (70. Read More

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Vitamin E Deficiency: An Under-Recognized Cause of Dystonia and Ataxia Syndrome.

Ann Indian Acad Neurol 2020 May-Jun;23(3):372-374. Epub 2020 Mar 30.

Department of Neurology, Kansas University Medical Center, Kansas City, KS, USA.

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Vitamin-Responsive Movement Disorders in Children.

Ann Indian Acad Neurol 2020 May-Jun;23(3):325-331. Epub 2020 Jun 5.

Department of Pediatrics, Lady Hardinge Medical College, New Delhi, India.

Movement disorders in childhood comprise a heterogeneous group of conditions that lead to impairment of voluntary movement, abnormal postures, or inserted involuntary movements. Movement disorders in children are frequently caused by metabolic disorders, both inherited and acquired. Many of these respond to vitamin supplementation. Read More

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MYONECROSIS AND DEATH DUE TO PRESUMED MICROCYSTIN TOXICOSIS IN AMERICAN WHITE PELICANS ().

J Zoo Wildl Med 2020 Jun;51(2):407-415

Zoo and Exotic Animal Pathology Service and Infectious Diseases Laboratory, University of Georgia, Athens, GA 30602, USA.

Over a period of 5 mo, seven out of eight American white pelicans () housed on a spring-fed pond at a zoo died or were euthanized. Clinical signs included inability to stand, anorexia, and weight loss. Clinicopathologic findings included heterophilic leukocytosis and elevated creatine kinase and aspartate aminotransferase. Read More

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Spontaneous Axonal Dystrophy in the Brain and Spinal Cord in Naïve Beagle Dogs.

Toxicol Pathol 2020 07 1;48(5):694-701. Epub 2020 Jun 1.

Global Pathology and Investigative Toxicology, Pfizer Inc, Groton, CT, USA.

Axonal dystrophy (AD) is a common age-related neurohistological finding in vertebrates that can be congenital or induced by xenobiotics, vitamin E deficiency, or trauma/compression. To understand the incidence and location of AD as a background finding in Beagle dogs used in routine toxicity studies, we examined central nervous system (CNS) and selected peripheral nervous system (PNS) tissues in twenty 18- to 24-month-old and ten 4- to 5-year-old control males and females. Both sexes were equally affected. Read More

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Increased anxiety-like behaviour is an early symptom of vitamin E deficiency that is suppressed by adrenalectomy in rats.

Br J Nutr 2020 Jun 1:1-10. Epub 2020 Jun 1.

Department of Agricultural Chemistry, School of Agriculture, Meiji University, Kawasaki, Kanagawa214-8571, Japan.

We previously reported that dietary vitamin E deficiency increased anxiety-like behaviour in rats exposed to social isolation. Here, we performed a detailed investigation of this phenomenon and its underlying mechanism. First, we fed Wistar rats with a vitamin E-free diet for 3 d, 1 week or 2 weeks and found an increase in anxiety-like behaviour after 1 and 2 weeks of vitamin E deficiency based on behavioural indicators. Read More

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