4,030 results match your criteria Vitamin E Deficiency

Functional Differentiation of Gene Homologous Copies in α-Tocopherol Biosynthesis Revealed by CRISPR/Cas9 Editing.

Front Plant Sci 2022 11;13:850924. Epub 2022 Apr 11.

Oil Crops Research Institute of Chinese Academy of Agricultural Sciences, Key Laboratory for Biological Sciences and Genetic Improvement of Oil Crops, Ministry of Agriculture and Rural Affairs, Wuhan, China.

Tocopherols are essential nutrients for human health known as vitamin E. Vitamin E deficiency can have a profound effect on human health, including the central nervous system and cardiovascular and immune protection. Multiple enzymatic steps are involved in the conversion between different forms of tocopherols. Read More

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The tocopherol transfer protein mediates vitamin E trafficking between cerebellar astrocytes and neurons.

J Biol Chem 2022 03 9;298(3):101712. Epub 2022 Feb 9.

Departments of Nutrition and Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA; Case Comprehensive Cancer Center, Cleveland, Ohio, USA. Electronic address:

Alpha-tocopherol (vitamin E) is an essential nutrient that functions as a major lipid-soluble antioxidant in humans. The alpha-tocopherol transfer protein (TTP) binds α-tocopherol with high affinity and selectivity and regulates whole-body distribution of the vitamin. Heritable mutations in the TTPA gene result in familial vitamin E deficiency, elevated indices of oxidative stress, and progressive neurodegeneration that manifest primarily in spinocerebellar ataxia. Read More

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Brown Bowel Syndrome: An Exceedingly Rare Condition with Longstanding Malabsorption and an Unusual Cause of Colon Pseudo-Obstruction.

Case Rep Gastroenterol 2021 Sep-Dec;15(3):960-965. Epub 2021 Nov 29.

Department of Pathology, Vivantes Klinikum Neukölln, Berlin, Germany.

Brown bowel syndrome (BBS) is an exceedingly rare condition usually associated with longstanding malabsorption of any etiology. As a result of vitamin E deficiency and subsequent mitochondrial degeneration due to oxidative stress induced by free radicals, lipofuscin granules accumulate in the smooth muscles of the gastrointestinal tract resulting in myopathy and dysmotility with underlying disease aggravation. The current study reports a BBS case in a 64-year-old female patient who had undergone jejunoileal bypass surgery as a bariatric procedure. Read More

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November 2021

Correlation of serum vitamin A and vitamin E levels with the occurrence and severity of preeclampsia.

Am J Transl Res 2021 15;13(12):14203-14210. Epub 2021 Dec 15.

Hospital Office, The Sixth People's Hospital of Zibo Zibo, Shandong Province, China.

Objective: To investigate the correlation of serum vitamin A and vitamin E levels with the occurrence and severity of preeclampsia.

Methods: The clinical data of 5,000 pregnant women in our hospital were retrospectively studied. Five hundred and sixty-five pregnant women with preeclampsia were divided into a mild group (259 cases) and a severe group (306 cases). Read More

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December 2021

Plasma Proteomics Characteristics of Subclinical Vitamin E Deficiency of Dairy Cows During Early Lactation.

Front Vet Sci 2021 10;8:723898. Epub 2021 Dec 10.

Heilongjiang Provincial Key Laboratory of Prevention and Control of Bovine Diseases, College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, China.

Vitamin E (VE) is an essential fat-soluble nutrient for dairy cows. Vitamin E deficiency leads to immune suppression and oxidative stress and increases the susceptibility of cows to reproductive disorders in the early post-partum period. However, studies on plasma proteomics of VE deficiency have not been reported so far. Read More

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December 2021

The Role of Vitamin Deficiency in Liver Disease: To Supplement or Not Supplement?

Nutrients 2021 Nov 10;13(11). Epub 2021 Nov 10.

Internal Medicine & Hepatology Section, Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties-PROMISE, University of Palermo Medical School, 90127 Palermo, Italy.

Over the past few years, growing interest has been shown for the impact of dietary requirements and nutritional factors on chronic diseases. As a result, nutritional programs have been reinforced by public health policies. The precise role of micronutrients in chronic liver disease is currently receiving particular attention since abnormalities in vitamin levels are often detected. Read More

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November 2021

Ataxia with vitamin E deficiency in the Philippines : A case report of two siblings.

J Med Invest 2021 ;68(3.4):400-403

Department of Neurology, Institute of Biomedical Sciences, Graduate School of Medicine, Tokushima University, Tokushima, Japan.

Here we report two siblings with ataxia and peripheral neuropathy. One patient showed head tremors. Genetic analysis revealed a mutation in the hepatic α-tocopherol transfer protein (α-TTP) gene (TTPA) on chromosome 8q13. Read More

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November 2021

Late complications of biliopancreatic diversion in an older patient: a case report.

BMC Geriatr 2021 11 4;21(1):631. Epub 2021 Nov 4.

Department of Geriatric Medicine, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium.

Background: In the mid-seventies, biliopancreatic diversion became popular as weight-loss surgery procedure. This bariatric procedure combines distal gastric resection and intestinal malabsorption, leading to greater weight loss and improvement of co-morbidities than other bariatric procedures. Nowadays, biliopancreatic diversion has become obsolete due to the high risk of nutritional complications. Read More

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November 2021

Vitamin E: How much is enough, too much and why!

Free Radic Biol Med 2021 12 23;177:212-225. Epub 2021 Oct 23.

Linus Pauling Institute, USA; Molecular and Cell Biology Program, Oregon State University, Corvallis, OR, USA.

α-Tocopherol (α-T) is a required dietary nutrient for humans and thus is a vitamin. This narrative review focuses on vitamin E structures, functions, biological determinants and its deficiency symptoms in humans. The mechanisms for the preferential α-T tissue enrichment in the human body include the α-T transfer protein (TTPA) and the preferential metabolism of non-α-T forms. Read More

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December 2021


J Zoo Wildl Med 2021 Sep;52(3):1061-1073

Department of Veterinary Anatomy, Physiology and Pathology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Neston CH64 7TE, United Kingdom.

A retrospective study revealed seven cases of coelomic steatitis in adult tentacled snakes (), including two males and five females, between May 2014 and August 2020. Common clinical signs included death after unusual floating, generalized weakness, inappetence, reduced body condition, coelomic distension, and reproductive pathology in females. Hematology of one specimen revealed marked monocytosis and lymphocytosis with mild heterophilia (chronic and active inflammation). Read More

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September 2021

Vitamin E supplementation in inflammatory skin diseases.

Dermatol Ther 2021 11 21;34(6):e15160. Epub 2021 Oct 21.

San Gallicano Dermatological Institute, Rome, Italy.

Vitamin E is a powerful lipophilic antioxidant that protects membranes from lipid peroxidation, and consequently, oxidative damage. Oxidative stress plays a role in the development of neurodegenerative diseases. Vitamin E supplementation is recommended in patients with vitamin E deficiency due to fat malabsorption. Read More

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November 2021

Deficiency of vitamins C and E in women of childbearing age in Brazil: a systematic review and meta-analysis.

Sao Paulo Med J 2021;139(6):545-555. Epub 2021 Sep 27.

PhD. Pharmacist and Professor, Department of Drugs and Medicines, School of Pharmaceutical Sciences, Universidade Estadual Paulista (UNESP), São Paulo (SP), Brazil.

Background: Despite the several options available for supplements containing vitamins C and E, evidence regarding the prevalence of deficiency or insufficiency of these vitamins is weak.

Objectives: To estimate the prevalence of deficiency or insufficiency of vitamins C and E and associated factors among women of childbearing age, in Brazil.

Design And Setting: Systematic review and meta-analysis conducted at a Brazilian public university. Read More

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November 2021

α-Tocopherol transfer protein (α-TTP).

Free Radic Biol Med 2021 11 24;176:162-175. Epub 2021 Sep 24.

Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

α-Tocopherol transfer protein (α-TTP) is so far the only known protein that specifically recognizes α-tocopherol (α-Toc), the most abundant and most biologically active form of vitamin E, in higher animals. α-TTP is highly expressed in the liver where α-TTP selects α-Toc among vitamin E forms taken up via plasma lipoproteins and promotes its secretion to circulating lipoproteins. Thus, α-TTP is a major determinant of plasma α-Toc concentrations. Read More

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November 2021

Expanding role of vitamin E in protection against metabolic dysregulation: Insights gained from model systems, especially the developing nervous system of zebrafish embryos.

Free Radic Biol Med 2021 11 20;176:80-91. Epub 2021 Sep 20.

Linus Pauling Institute, Corvallis, OR, USA; School of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, OR, USA. Electronic address:

This review discusses why the embryo requires vitamin E (VitE) and shows that its lack causes metabolic dysregulation and impacts morphological changes at very early stages in development, which occur prior to when a woman knows she is pregnant. VitE halts the chain reactions of lipid peroxidation (LPO). Metabolomic analyses indicate that thiols become depleted in E- embryos because LPO generates products that require compensation using limited amino acids and methyl donors that are also developmentally relevant. Read More

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November 2021

Reflections on a century of vitamin E research: Looking at the past with an eye on the future.

Angelo Azzi

Free Radic Biol Med 2021 11 1;175:155-160. Epub 2021 Sep 1.

School of Graduate Biomedical Pharmacology and Drug Development Program, Tufts University, Boston, MA, 02116, USA. Electronic address:

The name vitamin E, was given by Barnett and Sure who suggested that the factor proposed by Evans and Bishop as substance "X," be termed vitamin "E" as the next vitamin after the A, B, C and D vitamins had been already described. The identification of vitamin E with a-tocopherol was made in 1936 by Evans' group. One year later β-tocopherol and 11 years later δ-tocopherol were isolated. Read More

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November 2021

Increased α-tocopherol metabolism in horses with equine neuroaxonal dystrophy.

J Vet Intern Med 2021 Sep 31;35(5):2473-2485. Epub 2021 Jul 31.

Department of Population Health and Reproduction, School of Veterinary Medicine, University of California-Davis, Davis, California, USA.

Background: Equine neuroaxonal dystrophy/equine degenerative myeloencephalopathy (eNAD/EDM) is an inherited neurodegenerative disorder associated with a vitamin E deficiency within the first year of life. Vitamin E consists of 8 isoforms metabolized by the CYP4F2 enzyme. No antemortem diagnostic test currently exists for eNAD/EDM. Read More

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September 2021

Evaluation of nutritional status in pediatric patients diagnosed with Covid-19 infection.

Clin Nutr ESPEN 2021 08 11;44:424-428. Epub 2021 May 11.

Ankara City Hospital Child Health and Diseases Hospital Pediatric Infectious Clinic, Ankara, Turkey.

Aim: The aim of this study was to evaluate the nutritional status, the nutritional effect on the risk of infection and the severity of the disease, and the contribution of nutrition to the course of the infection in pediatric patients diagnosed with coronavirus disease who required additional nutritional support after hospitalization.

Methods: The body weight, height, body mass index, upper arm circumference, and triceps skinfold thickness of 49 patients aged 1 month to 18 years and diagnosed with Covid-19 and then hospitalized at the Ankara City Hospital, Pediatric Health and Diseases Hospital, Pediatric Infection ward between 15 May and 15 June 2020 were measured. Total protein, albumin, prealbumin, selenium, zinc, ferritin, folate, and selenium, C, D, E, and B12 levels were studied from blood drawn simultaneously from the patients. Read More

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GPX4 and vitamin E cooperatively protect hematopoietic stem and progenitor cells from lipid peroxidation and ferroptosis.

Cell Death Dis 2021 07 15;12(7):706. Epub 2021 Jul 15.

Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative Medicine, Jinan University, Guangzhou, China.

Ferroptosis, a newly defined mode of regulated cell death caused by unbalanced lipid redox metabolism, is implicated in various tissue injuries and tumorigenesis. However, the role of ferroptosis in stem cells has not yet been investigated. Glutathione peroxidase 4 (GPX4) is a critical suppressor of lipid peroxidation and ferroptosis. Read More

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Reversible tremor in an infant with vitamin E deficiency and cystic fibrosis.

Lancet 2021 07;398(10295):156

Child Neuropsychiatry, Department of Surgical Sciences, Dentistry, Gynaecology and Paediatrics, University of Verona, Verona, Italy. Electronic address:

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Serum vitamin E deficiency among people living with HIV and undergoing antiretroviral therapy at Ho Teaching Hospital, Ghana.

Heliyon 2021 Jun 17;7(6):e07339. Epub 2021 Jun 17.

Department of Pharmacology, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Vitamin E is a potent antioxidant that helps to counteract oxidative stress in the body. Oxidative stress is known to greatly affect people living with HIV (PLWH) through the stimulation of HIV replication and apoptosis of CD4+ T cells. There is however, a paucity of scientific data on the serum levels of vitamin E among PLWH in Ghana, and hence, there is a need to assess its level because of the pivotal role it plays in cell longevity determination and the immune system enhancement of such persons. Read More

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The Association Between Vitamin E Deficiency and Critically Ill Children With Sepsis and Septic Shock.

Front Nutr 2021 16;8:648442. Epub 2021 Jun 16.

Department of Pediatric Intensive Care Unit, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.

Literature is scarce on the assessment of vitamin E status in septic children. We aim to investigate the prevalence of vitamin E deficiency in critically ill children with sepsis and septic shock and its association with clinical features and outcomes. We compared serum vitamin E status between the confirmed or suspected infection and no infection groups, the sepsis shock and no sepsis shock groups upon pediatric intensive care unit admission. Read More

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Effects of mixed tocopherols added to milk replacer and calf starter on intake, growth, and indices of stress.

J Dairy Sci 2021 Sep 1;104(9):9769-9783. Epub 2021 Jul 1.

USDA Agricultural Research Service, Animal Biosciences and Biotechnology Laboratory, Beltsville, MD 20705.

Vitamin E comprises 8 fat-soluble isoforms: α-, β-, γ-, and δ-tocopherol and α-, β-, γ-, and δ-tocotrienol. Yet the body preferentially uses α-tocopherol, and only α-tocopherol supplementation can reverse vitamin E deficiency symptoms. However, other isoforms influence many biological functions in the body, including inflammation and stress. Read More

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September 2021

Gene Expression of CRAL_TRIO Family Proteins modulated by Vitamin E Deficiency in Zebrafish (Danio Rerio).

J Nutr Biochem 2021 Nov 10;97:108801. Epub 2021 Jun 10.

Linus Pauling Institute, Oregon State University, Corvallis, Oregon; School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon. Electronic address:

An evaluation of the impact of vitamin E deficiency on expression of the alpha-tocopherol transfer protein (α-TTP) and related CRAL_TRIO genes was undertaken using livers from adult zebrafish based on the hypothesis that increased lipid peroxidation would modulate gene expression. Zebrafish were fed either a vitamin E sufficient (E+) or deficient (E-) diet for 9 months, then fish were euthanized, and livers were harvested. Livers from the E+ relative to E- fish contained 40-times more α-tocopherol (P <0. Read More

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November 2021

Low Serum Vitamin E Level Associated with Low Hand Grip Strength in Community-Dwelling Adults: Korean National Health and Nutrition Examination Survey (KNHANES VII) 2016-2018.

Nutrients 2021 May 11;13(5). Epub 2021 May 11.

Division of Endocrinology, Department of Internal Medicine, Endocrine Research Institute, Yonsei University College of Medicine, Seoul 03722, Korea.

This study assessed the association between serum vitamin E levels and hand grip strength (HGS) in community-dwelling adults data of 1011 men aged 50 years and older and 1144 postmenopausal women were analyzed. Low HGS was defined as HGS below the sex-stratified median value. Proportion of low HGS was the greatest in the lowest quintile of serum vitamin E level (<10. Read More

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Metabolic and Toxic Myelopathies.

Semin Neurol 2021 06 19;41(3):309-326. Epub 2021 May 19.

Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Metabolic and toxic causes of myelopathy form a heterogeneous group of disorders. In this review, we discuss the causes of metabolic and toxic myelopathies with respect to clinical presentation, pathophysiology, diagnostic testing, treatment, and prognosis. This review is organized by temporal course (hyperacute, acute, subacute, and chronic) and etiology (e. Read More

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Effects of vitamin E on neurodegenerative diseases: an update.

Acta Neurobiol Exp (Wars) 2021 ;81(1):21-33

Gazi University , Faculty of Health Sciences , Nutrition and Dietetics Department , Ankara , Turkey.

Vitamin E deficiency is associated with many neurological problems. Although the mechanisms of vitamin E action in neurodegenerative diseases are not clear, there are many possible mechanisms. Examples of such mechanisms are the protective effects of vitamin E against oxidative stress damage and its suppressive role in the expression of many genes involved in the development of neurodegeneration. Read More

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November 2021

Vitamin E: necessary nutrient for neural development and cognitive function.

Maret G Traber

Proc Nutr Soc 2021 08 26;80(3):319-326. Epub 2021 Apr 26.

Linus Pauling Institute, College of Public Health and Human Sciences, Oregon State University, Corvallis, OR, USA.

Vitamin E, discovered in 1922, is essential for pregnant rats to carry their babies to term. However, 100 years later, the molecular mechanisms for the vitamin E requirement during embryogenesis remain unknown. Vitamin E's role during pregnancy has been difficult to study and thus, a vitamin E-deficient (E-) zebrafish embryo model was developed. Read More

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Sensory Axonopathy Associated With Vitamin E Deficiency.

Cureus 2021 Feb 17;13(2):e13389. Epub 2021 Feb 17.

Infectious Diseases, Saint Michael's Medical Center, Newark, USA.

Vitamin E deficiency can be observed in patients with malabsorption syndromes or inherited diseases such as ataxia. It is unusual for it to be a result of dietary insufficiency due to its presence in a wide variety of foods. Patients with vitamin E deficiency can present with neuromuscular disorders such as ataxia, hyporeflexia, spinocerebellar syndrome, as well as loss of vibration and proprioceptive sensation. Read More

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February 2021

[A cachectic man with a severe vitamin deficiency].

Ned Tijdschr Geneeskd 2021 03 11;165. Epub 2021 Mar 11.

Erasmus MC, afd. Heelkunde, Rotterdam.

A 57-year-old man, known with severe malnutrition, vitamin E deficiency and peripheral neuropathies, presented with vomiting and abdominal tenderness. There was a suspicion of ileus and small bowel obstruction. During the exploratory laparotomy a complete brown colored bowel without peristalsis was seen. Read More

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