3,913 results match your criteria Vitamin E Deficiency


Laboratory investigations.

Handb Clin Neurol 2018 ;154:287-298

Department of Pediatric Neurology, University Children's Hospital, University of Zurich, Zurich, Switzerland; Departments of Neurology and Ophthalmology, University Hospital Zurich, University of Zurich, Switzerland.

This chapter deals with chemical and hematologic investigations which are often considered in the diagnostic workup of subacute to chronic cerebellar ataxias. Relevant investigations in blood (serum, plasma), urine, and cerebrospinal fluid are discussed. Particular attention is paid to early diagnosis of treatable metabolic ataxias (such as abetalipoproteinemia, coenzyme Q10 deficiency, cerebrotendinous xanthomatosis, glucose transporter type 1 deficiency, Refsum disease, and vitamin E deficiency), but autoimmune ataxias, other vitamin deficiencies, and endocrine disorders should also be kept in mind. Read More

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January 2018

Recessive ataxias.

Handb Clin Neurol 2018 ;155:73-89

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom; Oxford Centre for Genomic Medicine, Oxford University Hospitals NHS Trust, Oxford, United Kingdom.

Recessive ataxias (spinocerebellar ataxias, recessive or SCARs) are a heterogeneous group of rare, mostly neurodegenerative genetic disorders which usually start in childhood or early adult life. They can be subdivided into two major groups: predominant sensory or afferent ataxias, which are disorders mainly of the peripheral input to the cerebellum, and predominant cerebellar ataxias, in which the cerebellum is primarily affected. Next-generation sequencing technology has enabled the identification of >100 novel SCAR genes in the last 5 years, although most of them are ultrarare. Read More

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January 2018

Spastic ataxias.

Handb Clin Neurol 2018 ;155:191-203

Neuroscience Axis, CHU de Québec-Laval University, Quebec, QC, Canada; Neuromuscular and Neurogenetic Disease Clinic, CHU de Québec-Laval University, Quebec, QC, Canada. Electronic address:

The presence of spasticity and pyramidal features is a hallmark of some of hereditary ataxias, such as autosomal-recessive spastic ataxia of Charlevoix-Saguenay, other primary spastic ataxias, Friedreich ataxia, or ataxia with isolated vitamin E deficiency. Certain spastic paraplegias, such as spastic paraplegia 7, may present as an ataxic phenotype and often share common pathophysiologic pathways with cerebellar ataxias. Because of the rarity and genetic heterogeneity of these conditions, their molecular diagnosis remains challenging and time consuming. Read More

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January 2018

Pediatric Ataxia: Focus on Chronic Disorders.

Semin Pediatr Neurol 2018 Apr 5;25:54-64. Epub 2018 Jan 5.

Departments of Pediatrics and Neurology, The Children's Hospital of Philadelphia, Philadelphia, PA; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Evaluation of a pediatric patient presenting with ataxia can be expensive and time consuming. Acute causes tend to have a clear developmental paradigm, but chronic presentations are more likely to be secondary to a genetic disorder, either one that primarily causes ataxia or that presents ataxia as one of a multitude of symptoms. Evaluation should focus on a quick diagnosis for those that have treatment options and for those that require other systemic monitoring. Read More

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Current and promising therapies in autosomal recessive ataxias.

CNS Neurol Disord Drug Targets 2018 Apr 18. Epub 2018 Apr 18.

Laval University and CHU de Quebec - Laval University, Axe neurosciences - Department of Medicine, Faculty of Medicine Quebec, Quebec. Canada.

Background & Objective: Ataxia is clinically characterized by unsteady gait and imbalance. Cerebellar disorders may arise from many causes such as metabolic diseases, stroke or genetic mutations. The genetic causes are classified by mode of inheritance and include autosomal dominant, X-linked and autosomal recessive ataxias. Read More

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April 2018
1 Read

Regulation and function of avian selenogenome.

Biochim Biophys Acta 2018 Apr 5. Epub 2018 Apr 5.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing 100083, China; Department of Animal Science, Cornell University, Ithaca, NY 14853, USA. Electronic address:

Background: Selenium (Se) is an essential micronutrient required by avian species. Dietary Se/vitamin E deficiency induces three classical diseases in chicks: exudative diathesis, nutritional pancreatic atrophy, and nutritional muscular dystrophy.

Scope Of Review: This review is to summarize and analyze the evolution, regulation, and function of avian selenogenome and selenoproteome and their relationship with the three classical Se/vitamin E deficiency diseases. Read More

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April 2018
2 Reads

Prevalence of fat-soluble vitamin (A, D, and E) and zinc deficiency in patients with cirrhosis being assessed for liver transplantation.

Acta Gastroenterol Belg 2017 Apr-Jun;80(2):237-241

Department of Medicine, Division of Gastroenterology and Hepatology, Western University and London Health Sciences Centre, London, Ontario, Canada.

Purpose: To evaluate the prevalence of fat-soluble vitamin (A, D, and E) and zinc deficiency in patients with cirrhosis being assessed for liver transplantation and the correlations between vitamin deficiencies, nutritional markers, and severity of liver disease.

Methods: This is a single centre retrospective study. Serum vitamin A, D, E, and zinc levels were collected in adult patients being assessed for liver transplantation between January and July 2012. Read More

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Update on Vitamin E and Its Potential Role in Preventing or Treating Bronchopulmonary Dysplasia.

Neonatology 2018 7;113(4):366-378. Epub 2018 Mar 7.

Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Vitamin E is obtained only through the diet and has a number of important biological activities, including functioning as an antioxidant. Evidence that free radicals may contribute to pathological processes such as bronchopulmonary dysplasia (BPD), a disease of prematurity associated with increased lung injury, inflammation and oxidative stress, led to trials of the antioxidant vitamin E (α-tocopherol) to prevent BPD with variable results. These trials were all conducted at supraphysiologic doses and 2 of these trials utilized a formulation containing a potentially harmful excipient. Read More

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March 2018
1 Read

Water-Soluble Vitamin E-Tocopheryl Phosphate.

Authors:
Jean-Marc Zingg

Adv Food Nutr Res 2018;83:311-363. Epub 2018 Feb 12.

Miller School of Medicine, University of Miami, Miami, FL, United States. Electronic address:

The hydrophobicity of vitamin E poses transport and metabolic challenges to regulate its bioavailability and to prevent its accumulation in lipid-rich tissues such as adipose tissue, brain, and liver. Water-soluble precursors of vitamin E (α-tocopherol, αT), such as its esters with acetate (αTA), succinate (αTS), or phosphate (αTP), have increased solubility in water and stability against reaction with free radicals, but they are rapidly converted during their uptake into the lipid-soluble vitamin E. Therefore, the bioavailability of these precursors as intact molecules is low; nevertheless, at least for αTS and αTP, the recent research has revealed unique regulatory effects on signal transduction and gene expression and the modulation of cellular events ranging from proliferation, survival/apoptosis, lipid uptake and metabolism, phagocytosis, long term potentiation, cell migration, telomere maintenance, and angiogenesis. Read More

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Vitamin E Status Is Inversely Associated with Risk of Incident Tuberculosis Disease among Household Contacts.

J Nutr 2018 Jan;148(1):56-62

Department of Global Health and Social Medicine, and Division of Global Health Equity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Background: Few studies have previously assessed how pre-existing vitamin E status is associated with risk of tuberculosis (TB) disease progression.

Objective: We evaluated the association between baseline plasma concentrations of 3 vitamin E isomers (α-tocopherol, γ-tocopherol, and δ-tocopherol) and TB disease risk.

Methods: We conducted a case-control study nested within a longitudinal cohort of household contacts (HHCs) of pulmonary TB cases in Lima, Peru. Read More

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January 2018
3 Reads

Case 35-2017. A 57-Year-Old Woman with Hypoesthesia and Weakness in the Legs and Arms.

N Engl J Med 2017 11;377(20):1977-1984

From the Departments of Neurology (M.P.B., W.S.D., T.A.C.) and Pathology (A.S.D.), Massachusetts General Hospital, and the Departments of Neurology (M.P.B., W.S.D., T.A.C.) and Pathology (A.S.D.), Harvard Medical School - both in Boston.

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November 2017
7 Reads

Hepatic accumulation of S-Adenosylmethionine in hamsters with non-alcoholic-fatty liver disease associated to metabolic syndrome under selenium and vitamin E deficiency.

Clin Sci (Lond) 2017 Nov 9. Epub 2017 Nov 9.

EURECAT, Reus, Spain.

Progression of non-alcoholic fatty liver disease (NAFLD) in the context of metabolic syndrome (MetS) is only partially explored due to the lack of preclinical models. In order to study the alterations in hepatic metabolism that accompany this condition, we developed a model of MetS accompanied by the onset of steatohepatitis (NASH) by challenging golden hamsters with a high fat diet low in vitamin E and selenium (HFD), since combined deficiency results in hepatic necroinflammation in rodents. Metabolomics and transcriptomics integrated analyses of livers revealed an unexpected accumulation of hepatic S-Adenosylmethionine (SAM) when compared with healthy livers likely due to diminished methylation reactions and repression of GNMT. Read More

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November 2017
4 Reads

Diagnosis of multiple system atrophy.

Auton Neurosci 2018 May 23;211:15-25. Epub 2017 Oct 23.

Department of Neurology, Dysautonomia Center, New York University School of Medicine, NY, USA. Electronic address:

Multiple system atrophy (MSA) may be difficult to distinguish clinically from other disorders, particularly in the early stages of the disease. An autonomic-only presentation can be indistinguishable from pure autonomic failure. Patients presenting with parkinsonism may be misdiagnosed as having Parkinson disease. Read More

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May 2018
4 Reads

Vitamin E in the Preterm Infant: A Forgotten Cause of Hemolytic Anemia.

Am J Perinatol 2018 Feb 10;35(3):305-310. Epub 2017 Oct 10.

Division of Neonatology, Department of Pediatrics, University of Kentucky, Lexington, Kentucky.

Objective:  Vitamin E deficiency in premature infants has been associated with hemolytic anemia. Its incidence decreased after the supplementation of preterm formulas and parenteral nutrition with vitamin E. Despite this, some infants still develop hemolytic anemia and receive vitamin E. Read More

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February 2018
2 Reads

Epidemiology of Cerebellar Diseases and Therapeutic Approaches.

Authors:
Michael S Salman

Cerebellum 2018 Feb;17(1):4-11

Section of Pediatric Neurology, Children's Hospital, AE 308, 820 Sherbrook Street, Winnipeg, MB, R3A 1R9, Canada.

Diseases involving the cerebellum occur relatively commonly in children and adults around the globe. Many factors influence their epidemiology including geography, ethnicity, consanguinity, and the methodology used to ascertain patients. In addition, reliable epidemiological data rely heavily on accurate disease classification. Read More

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February 2018
5 Reads

Vitamin E Deficiency and Oxidative Status are Associated with Prediabetes in Apparently Healthy Subjects.

Arch Med Res 2017 Apr;48(3):257-262

Facultad de Medicina y Nutrición, Universidad Juárez del Estado de Durango, Durango, Dgo., México.

Background: Previous studies have indicated that vitamin E deficiency and oxidative stress affect the beta cell function. Hence, the aim of this study was to determine the association between vitamin E deficiency and oxidative status with prediabetes in apparently healthy subjects.

Methods: Apparently healthy men and women aged 18-65 years were enrolled in a case-control study. Read More

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April 2017
2 Reads

Defense-Related Transcriptional Reprogramming in Vitamin E-Deficient Arabidopsis Mutants Exposed to Contrasting Phosphate Availability.

Front Plant Sci 2017 10;8:1396. Epub 2017 Aug 10.

Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, University of BarcelonaBarcelona, Spain.

Vitamin E inhibits the propagation of lipid peroxidation and helps protecting photosystem II from photoinhibition, but little is known about its possible role in plant response to Pi availability. Here, we aimed at examining the effect of vitamin E deficiency in mutants on phytohormone contents and the expression of transcription factors in plants exposed to contrasting Pi availability. Plants were subjected to two doses of Pi, either unprimed (controls) or previously exposed to low Pi (primed). Read More

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August 2017
2 Reads

Chronic vitamin E deficiency impairs cognitive function in adult zebrafish via dysregulation of brain lipids and energy metabolism.

Free Radic Biol Med 2017 Nov 5;112:308-317. Epub 2017 Aug 5.

Linus Pauling Institute, Oregon State University, Corvallis, OR 97330, USA; College of Public Health and Human Sciences, Oregon State University, Corvallis, OR 97330, USA. Electronic address:

Zebrafish (Danio rerio) are a recognized model for studying the pathogenesis of cognitive deficits and the mechanisms underlying behavioral impairments, including the consequences of increased oxidative stress within the brain. The lipophilic antioxidant vitamin E (α-tocopherol; VitE) has an established role in neurological health and cognitive function, but the biological rationale for this action remains unknown. In the present study, we investigated behavioral perturbations due to chronic VitE deficiency in adult zebrafish fed from 45 days to 18-months of age diets that were either VitE-deficient (E-) or VitE-sufficient (E+). Read More

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November 2017
11 Reads

Thyroid function of steatitis-affected Mozambique tilapia Oreochromis mossambicus from a sub-tropical African reservoir.

Dis Aquat Organ 2017 07;125(2):101-113

Sustainability Research Unit, Nelson Mandela Metropolitan University, Private Bag x6531, George 6530, South Africa.

Thyroid function and nutritional indicators were measured in obese, steatitis-affected Mozambique tilapia Oreochromis mossambicus from Loskop Reservoir (LR), South Africa. Plasma thyroid hormones (especially T3) and thyroid follicle histomorphology revealed high levels of activity in every aspect of the thyroid cascade measured in fish from LR compared to a reference population of steatitis-free fish. Concurrent measurements of nutritional state including plasma lipids, liver lipid content and hepatocyte size showed that fish from LR had significant energy stores indicative of abundant nutritional intake. Read More

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July 2017
4 Reads

Ataxia in children: think about vitamin E deficiency ! (comment on: ataxia in children: early recognition and clinical evaluation).

Ital J Pediatr 2017 Jul 19;43(1):62. Epub 2017 Jul 19.

Pediatrics Department, Setif University Hospital, Genetic & Nutritional Diseases Laboratory, Setif-1 University, 19000, Setif, Algeria.

A recent article from Pavone et al. published in the Italian Journal of Pediatrics entitled «Ataxia in children: early recognition and clinical evaluation» made an exhaustive overview of the large spectrum of pediatric ataxias. However, we would underline the importance of considering hereditary ataxia due to isolated vitamin E deficiency as a specific and treatable cause of child ataxia. Read More

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July 2017
3 Reads

The risk of plasma vitamin A, C, E and D deficiency in patients with metabolic syndrome: A case-control study.

Adv Clin Exp Med 2017 Jul;26(4):581-586

Department of Internal and Infectious Diseases, Medical University of Łódz, Poland.

Background: The increasing incidence of metabolic diseases such as obesity or diabetes have made them a major public health problem. Increasing oxidative stress induced by reactive oxygen species, which initiate the oxidative adverse changes in the cell, is mentioned, among other risk factors, to underlie these diseases. Vitamin A, C and E are listed among the non-enzymatic mechanisms counteracting this phenomenon. Read More

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July 2017
13 Reads

Vitamin E deficiency during embryogenesis in zebrafish causes lasting metabolic and cognitive impairments despite refeeding adequate diets.

Free Radic Biol Med 2017 Sep 20;110:250-260. Epub 2017 Jun 20.

Linus Pauling Institute, Oregon State University, Corvallis, OR 97330, USA; College of Public Health and Human Sciences, Oregon State University, Corvallis, OR 97330, USA. Electronic address:

Vitamin E (α-tocopherol; VitE) is a lipophilic antioxidant required for normal embryonic development in vertebrates, but the long-term effects of embryonic VitE deficiency, and whether they are ameliorated by feeding VitE-adequate diets, remain unknown. We addressed these questions using a zebrafish (Danio rerio) model of developmental VitE deficiency followed by dietary remediation. Adult zebrafish maintained on VitE-deficient (E-) or sufficient (E+) diets were spawned to obtained E- and E+ embryos, respectively, which we evaluated up to 12 days post-fertilization (dpf). Read More

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September 2017
5 Reads

Severe but reversible neuropathy and encephalopathy due to vitamin E deficiency.

Clin Neurol Neurosurg 2017 Sep 8;160:19-20. Epub 2017 Jun 8.

Queen Elizabeth Hospital, University Hospitals of Birmingham, Birmingham, UK; School of Life and Health Sciences, Aston Brain Centre, Aston University, Birmingham, UK. Electronic address:

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September 2017
4 Reads

Many tocopherols, one vitamin E.

Authors:
Angelo Azzi

Mol Aspects Med 2018 Jun 19;61:92-103. Epub 2017 Jun 19.

Vascular Biology Laboratory, JM USDA-HNRCA at Tufts University, Boston, MA 02111, USA. Electronic address:

Four tocopherols are available in nature and are absorbed with the diet, but only one RRR-α-tocopherol satisfies the criteria of being a vitamin. The biological activity of the different tocopherols studied in the rat by the resorption-gestation test has been inconsistently extrapolated to human beings where the tocopherols have no influence on a successful pregnancy. Diminution of RRR-α-tocopherol intake results in diseases characterized by ataxia, whose pathogenetic mechanism, despite vigorous claims, has not been clarified. Read More

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June 2018
1 Read

Effect of RRR-α-tocopherol supplementation on serum of breastfeeding women up to 60 days after delivery: a randomised controlled trial.

J Hum Nutr Diet 2017 Dec 23;30(6):771-778. Epub 2017 May 23.

Department of Biochemistry, Federal University of Rio Grande do Norte, Natal, RN, Brazil.

Background: Maternal supplementation is a viable strategy to combat vitamin E deficiency in newborns, although a protocol for maternal vitamin E supplementation has not been defined. The present study assessed the effect of maternal supplementation in a single dose on the serum of postpartum women up to 60 days after delivery.

Methodology: Fifty healthy breastfeeding women were recruited at two maternity hospitals both located in Natal, RN, Brazil. Read More

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December 2017
2 Reads

Pansteatitis in polluted Olifants River impoundments: nutritional perspectives on fish in a eutrophic lake, Lake Loskop, South Africa.

J Fish Dis 2017 Nov 11;40(11):1665-1680. Epub 2017 May 11.

Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa.

This study compares the aetiology of pansteatitis in Lake Loskop, relative to two other impoundments along the Olifants River. Macroscopic and microscopic pathology, age determination and analysis of stomach content, fatty acids and stable isotopes explain the high prevalence of pansteatitis in Oreochromis mossambicus (Peters) and several other species in Lake Loskop. All the dietary indicator comparisons between pansteatitis-affected and healthy fish fail to support a systemic cause. Read More

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November 2017
4 Reads

Effects of feeding two RRR-α-tocopherol formulations on serum, cerebrospinal fluid and muscle α-tocopherol concentrations in horses with subclinical vitamin E deficiency.

Equine Vet J 2017 Nov 25;49(6):753-758. Epub 2017 May 25.

Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, California, USA.

Background: Alpha-tocopherol (α-TP) supplementation is recommended for the prevention of various equine neuromuscular disorders. Formulations available include RRR-α-TP acetate powder and a more expensive but rapidly water-dispersible liquid RRR-α-TP (WD RRR-α-TP). No cost-effective means of rapidly increasing serum and cerebrospinal fluid (CSF) α-TP with WD RRR-α-TP and then sustaining concentrations with RRR-α-TP acetate has yet been reported. Read More

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November 2017
2 Reads

The Inhibitory Effect of Nodakenin on Mast-Cell-Mediated Allergic Inflammation Via Downregulation of NF-κB and Caspase-1 Activation.

J Cell Biochem 2017 11 30;118(11):3993-4001. Epub 2017 May 30.

Department of Pharmacology, College of Korean Medicine, Sangji University, Gangwon-do 220-702, Republic of Korea.

Nodakenin, a coumarin isolated from the roots of Angelicae gigas, is effective for treating function control disorders, bacterial infections, pain, diarrhea, vitamin E deficiency, and for relaxation of the uterus. The aim of this study was to investigate the antiallergic related inflammatory effects in phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated human mast cells (HMC-1) or anaphylactic activity in a mouse model. Nodakenin inhibited the mRNA expression and production of pro-inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β in PMACI-stimulated HMC-1. Read More

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November 2017
4 Reads

Vitamin E-coated dialysis membranes reduce the levels of oxidative genetic damage in hemodialysis patients.

Mutat Res 2017 Mar 3;815:16-21. Epub 2017 Feb 3.

Fundació Puigvert, Barcelona, Spain. Electronic address:

End-stage renal disease patients present oxidative stress status that increases when they are submitted to hemodialysis (HD). This increase in oxidative stress can affect their genetic material, among other targets. The objective of this study was to evaluate the effect of using polysulfone membranes coated with vitamin E, during the HD sessions, on the levels of genetic damage of HD patients. Read More

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March 2017
1 Read

Vitamin E supplementation in people with cystic fibrosis.

Cochrane Database Syst Rev 2017 03 6;3:CD009422. Epub 2017 Mar 6.

West Midlands Adult Cystic Fibrosis Centre, Heart of England NHS Foundation Trust, Bordesley Green East, Birmingham, UK, B9 5SS.

Background: People with cystic fibrosis are at an increased risk of fat-soluble vitamin deficiency including vitamin E. Vitamin E deficiency can cause a host of conditions such as haemolytic anaemia, cerebellar ataxia and cognitive difficulties. Vitamin E supplementation is widely recommended in cystic fibrosis and aims to ameliorate this deficiency. Read More

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March 2017
2 Reads

Histomorphology, ultrastructure and fatty acid composition of the adipose tissue in pansteatitis, the potentials in understanding the underlying mechanism and diagnosis of pansteatitis in the Nile crocodile.

Lipids Health Dis 2017 Feb 23;16(1):47. Epub 2017 Feb 23.

Anatomy and Physiology Department, Faculty of Veterinary Science, University of Pretoria, Onderstepoort 0110, Pretoria, South Africa.

Background: In an effort to characterize the fat body and other adipose tissue in the Nile crocodile and the effects of pansteatitis on the structure and composition of the adipose tissue, we evaluated the regional variation in structure and fatty acid composition of healthy farmed crocodiles and those affected by pansteatitis.

Methods: Adipose tissue samples were collected from the subcutaneous, visceral and intramuscular fat and the abdominal fat body of ten 4-year old juvenile crocodiles from Izinthaba Crocodile Farm, Pretoria, South Africa while pansteatitis samples were collected from visceral and intramuscular fat of crocodiles that had died of pansteatitis at the Olifant River, Mpumalanga, also in South Africa. Histomorphology, ultrastrustucture and fatty acid composition by fatty acid methyl ester (FAME) analysis were conducted. Read More

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February 2017
1 Read

The dietary protein paradox and threonine N-depletion: Pyridoxal-5'-phosphate enzyme activity as a mechanism for the δ N trophic level effect.

Rapid Commun Mass Spectrom 2017 Apr;31(8):705-718

Department of Physiology of Energy Metabolism, German Institute of Human Nutrition in Potsdam-Rehbruecke (DIfE), Arthur-Scheunert-Allee 114-116, D-14558, Nuthetal, Germany.

Rationale: Nitrogen stable isotope ratios (δ N values) are used to reconstruct dietary patterns, but the biochemical mechanism(s) responsible for the diet to tissue trophic level effect and its variability are not fully understood. Here δ N amino acid (AA) values and physiological measurements (nitrogen intake, plasma albumin concentrations, liver-reduced glutathione concentrations and leucine oxidation rates) are used to investigate increased dietary protein consumption and oxidative stress (vitamin E deficiency) in rat total plasma protein.

Methods: Using gas chromatography/combustion/isotope ratio mass spectrometry, the δ N values from N-pivaloyl-i-propyl esters of 15 AAs are reported for rats (n = 40) fed casein-based diets with: adequate protein (AP, 13. Read More

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April 2017
36 Reads

50 Years Ago in The Journal of Pediatrics: Vitamin E Deficiency: A Previously Unrecognized Cause of Hemolytic Anemia in the Premature Infant.

J Pediatr 2017 Feb;181:162

Division of Gastroenterology, Hepatology, and Nutrition Boston Children's Hospital Boston, Massachusetts.

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February 2017
1 Read

Liver Transplantation as a Treatment for Severe Refractory Vitamin E Deficiency Related to Progressive Familial Intrahepatic Cholestasis Type 2 in a Pediatric Patient.

ACG Case Rep J 2016 Aug 21;3(4):e193. Epub 2016 Dec 21.

Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic Children's Hospital, Cleveland, OH.

Refractory vitamin E deficiency is thought to have irreversible effects on neurologic function. We report an adolescent boy with severe refractory vitamin E deficiency due to progressive familial intrahepatic cholestasis (PFIC) type 2. His consequent neurologic dysfunction included severe ataxia, dysmetria, dysarthria, and cranial nerve VI palsy. Read More

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August 2016
1 Read

Lethal dysregulation of energy metabolism during embryonic vitamin E deficiency.

Free Radic Biol Med 2017 03 14;104:324-332. Epub 2017 Jan 14.

Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA; College of Public Health and Human Sciences, Oregon State University, Corvallis, OR 97331, USA; Environmental Health Sciences Center, Oregon State University, Corvallis, OR 97331, USA. Electronic address:

Vitamin E (α-tocopherol, VitE) was discovered in 1922 for its role in preventing embryonic mortality. We investigated the underlying mechanisms causing lethality using targeted metabolomics analyses of zebrafish VitE-deficient embryos over five days of development, which coincided with their increased morbidity and mortality. VitE deficiency resulted in peroxidation of docosahexaenoic acid (DHA), depleting DHA-containing phospholipids, especially phosphatidylcholine, which also caused choline depletion. Read More

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March 2017
2 Reads

Synthesis, characterization, and in-vitro antitumor activity of the polyethylene glycol (350 and 1000) succinate derivatives of the tocopherol and tocotrienol isomers of Vitamin E.

Int J Pharm 2017 Mar 16;519(1-2):145-156. Epub 2017 Jan 16.

College of Health and Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA, USA; College of Pharmacy, Taipei Medical University, Taipei, Taiwan. Electronic address:

Vitamin E refers to a group of saturated tocopherol (T) isomers and the biologically more active unsaturated tocotrienol (T) isomers. PEGylated α-tocopherol, commercially known as Vitamin E TPGS, has been used as an emulsifier and therapeutic agent for children with vitamin E deficiency. Limited information, however, is available about the PEG conjugates of the tocotrienol isomers of vitamin E. Read More

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March 2017
10 Reads

Analysis of the concentration of vitamin E in erythrocytes of patients with celiac disease.

Prz Gastroenterol 2016 20;11(4):282-285. Epub 2016 Jul 20.

Department of Paediatrics, Institute of Mother and Child, Warsaw, Poland.

Introduction: Consumption of gluten proteins leads to an enteropathy characterised by lymphocytic infiltration of mucous membrane, crypts hypertrophy, and atrophy of villi. Enteropathy leads to disturbances in the immune system as well as secondary deficiency of vitamin E.

Aim: Analysis of the concentration of vitamin E in erythrocytes of patients with celiac disease. Read More

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July 2016
1 Read

Relationship between deficiencies in vitamin A and E and occurrence of infectious diseases among children.

Eur Rev Med Pharmacol Sci 2016 12;20(23):5009-5012

Department of Pediatrics, Daqing Longnan Hospital, Daqing, Heilongjiang, China.

Objective: To investigate the relationship between vitamin A deficiency (VAD), vitamin E deficiency (VED) and infectious diseases.

Patients And Methods: We chose 684 cases of healthy children age 5 months-12 years from our hospital, measured their VA, VE from vein under the light proof condition with high-pressure liquid chromatography. Thereafter, the children who get the acute respiratory tract infection (ARI) or diarrhea two weeks later were registered. Read More

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December 2016
2 Reads

Effects of dietary vitamin E deficiency on systematic pathological changes and oxidative stress in fish.

Oncotarget 2016 Dec;7(51):83869-83879

Department of Aquaculture, Sichuan Agricultural University, Chengdu, Sichuan, China.

The aim of this study was to investigate the effects of dietary vitamin E deficiency on systematic pathological changes and oxidative stress in fish. A total of 320 healthy common carp (Cyprinus carpio) were randomized into four groups; the control group was fed a basal diet supplemented with 100 IUkg-1 of vitamin E, while the three experimental groups were fed the same basal diet with reduced vitamin E content (0, 25, or 50 IUkg-1). Findings showed that fish in the experimental groups mainly presented with sekoke disease, exophthalmia, leprnorthsis, and ascites. Read More

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December 2016
2 Reads

Vitamin E deficiency depressed fish growth, disease resistance, and the immunity and structural integrity of immune organs in grass carp (Ctenopharyngodon idella): Referring to NF-κB, TOR and Nrf2 signaling.

Fish Shellfish Immunol 2017 Jan 22;60:219-236. Epub 2016 Nov 22.

Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Chengdu 611130, China. Electronic address:

This study investigated the effects of dietary vitamin E on growth, disease resistance and the immunity and structural integrity of head kidney, spleen and skin in grass carp (Ctenopharyngodon idella). The fish were fed six diets containing graded levels of vitamin E (0, 45, 90, 135, 180 and 225 mg/kg diet) for 10 weeks. Subsequently, a challenge test was conducted by injection of Aeromonas hydrophila. Read More

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January 2017
15 Reads

Prevalence of the Novel Torque Teno Sus Virus Species k2b from Pigs in the United States and Lack of Association with Post-Weaning Multisystemic Wasting Syndrome or Mulberry Heart Disease.

Transbound Emerg Dis 2017 Dec 23;64(6):1877-1883. Epub 2016 Nov 23.

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.

The family Anelloviridae includes a number of viruses infecting humans (Torque teno viruses, TTV) and other animals including swine (Torque teno sus viruses, TTSuV). Two genetically distinct TTSuV species have been identified from swine thus far (TTSuV1 and TTSuVk2), although their definitive association with disease remains debatable. In 2012, a novel TTSuV species was identified from commercial swine serum and classified in the genus Kappatorquevirus as TTSuVk2b. Read More

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December 2017

Transcriptome profiling of equine vitamin E deficient neuroaxonal dystrophy identifies upregulation of liver X receptor target genes.

Free Radic Biol Med 2016 12 15;101:261-271. Epub 2016 Oct 15.

Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, United States.

Specific spontaneous heritable neurodegenerative diseases have been associated with lower serum and cerebrospinal fluid α-tocopherol (α-TOH) concentrations. Equine neuroaxonal dystrophy (eNAD) has similar histologic lesions to human ataxia with vitamin E deficiency caused by mutations in the α-TOH transfer protein gene (TTPA). Mutations in TTPA are not present with eNAD and the molecular basis remains unknown. Read More

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December 2016
5 Reads

Minimum Selenium Requirements Increase When Repleting Second-Generation Selenium-Deficient Rats but Are Not Further Altered by Vitamin E Deficiency.

Biol Trace Elem Res 2017 May 17;177(1):139-147. Epub 2016 Oct 17.

Department of Nutritional Sciences, University of Wisconsin, 1415 Linden Drive, Madison, WI, 53706, USA.

Second-generation selenium-deficient weanling rats fed graded levels of dietary Se were used (a) to study the impact of initial Se deficiency on dietary Se requirements; (b) to determine if further decreases in selenoperoxidase expression, especially glutathione peroxidase 4 (Gpx4), affect growth or gross disease; and (c) to examine the impact of vitamin E deficiency on biochemical and molecular biomarkers of Se status. Rats were fed a vitamin E-deficient and Se-deficient crystalline amino acid diet (3 ng Se/g diet) or that diet supplemented with 100 μg/g all-rac-α-tocopheryl acetate and/or 0, 0.02, 0. Read More

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May 2017
2 Reads

Ataxia due to isolated vitamin E deficiency from South India.

J Assoc Physicians India 2016 Jan;64(1):135

Medical College Hospital, Trivandrum.

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January 2016
2 Reads

Deficiency of fat-soluble vitamins in chronic pancreatitis: A systematic review and meta-analysis.

Pancreatology 2016 Nov - Dec;16(6):988-994. Epub 2016 Sep 20.

Digestive & Liver Disease Unit, S. Andrea Hospital, University "Sapienza", Rome, Italy. Electronic address:

Background And Aims: Chronic pancreatitis (CP) patients are at risk for fat-soluble vitamins (A, D, E, K) deficiency, but available studies are small and heterogeneous. We conducted a systematic review and meta-analysis to determine the prevalence of fat-soluble vitamins deficiency in CP patients.

Methods: Medline was searched up to January 2016 for case series and case-control studies reporting prevalence of fat-soluble vitamin deficiency in CP patients. Read More

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April 2017
2 Reads

Probucol dramatically enhances dihydroartemisinin effect in murine malaria.

Malar J 2016 09 15;15:472. Epub 2016 Sep 15.

Research Unit for Functional Genomics, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro City, Hokkaido, Japan.

Background: Artemisinin-based combination therapy (ACT) has been adopted as national policy for the first-line treatment in large number of malaria-endemic regions. However, artemisinin-resistant parasites have emerged and are spreading, with slow-cleaning parasites being reported in patients treated with ACT. It means that more parasites are exposed to the partner drug alone and the risk of developing resistant parasites against the partner drug is increasing. Read More

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September 2016
3 Reads

Lower Plasma Levels of Antioxidant Vitamins in Patients with Metabolic Syndrome: A Case Control Study.

Adv Clin Exp Med 2016 Jul-Aug;25(4):689-700

Department of Internal and Infectious Diseases, Medical University of Lodz, Poland.

Background: Metabolic syndrome (MS) is a coexistence of metabolic risk factors affecting the development of cardiovascular diseases. Reactive oxygen species, which are excessively produced in MS, participate in its pathogenesis. Vitamins A, C and E are an important part of the non-enzymatic antioxidative barrier in humans. Read More

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January 2017
8 Reads

Clinical and Pathologic Features of a Suspected Selenium Deficiency in Captive Plains Zebras.

Biol Trace Elem Res 2017 Mar 23;176(1):114-119. Epub 2016 Aug 23.

Chongqing Medical University, Chongqing, 400016, People's Republic of China.

Previous studies have shown that selenium (Se) deficiency is associated with nutritional myopathy, known as white muscle disease (WMD), in horses. However, correlations between Se deficiency and clinical findings, such as hematologic biochemical values and pathological features, have not been evaluated in captive plains zebras. The purpose of the present study was to investigate the clinical and pathologic features that may be caused by a Se deficiency in the captive plains zebra. Read More

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March 2017
3 Reads