1,722 results match your criteria Vitamin D Deficiency and Related Disorders


Vitamin D levels are not associated with non-alcoholic fatty liver disease severity in a Brazilian population.

Int J Vitam Nutr Res 2020 Jul 8:1-8. Epub 2020 Jul 8.

Departamento de Clínica Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

Some epidemiological evidence suggests an inverse correlation between non-alcoholic fatty liver disease (NAFLD) frequency and vitamin D levels. Likewise, a beneficial effect of vitamin D on diabetes mellitus (DM) and insulin resistance has been observed, but this is an unsolved issue. Thus, we aimed to investigate the prevalence of hypovitaminosis D in a NAFLD Brazilian population and its association with disease severity and presence of comorbidities. Read More

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http://dx.doi.org/10.1024/0300-9831/a000667DOI Listing

Association of Serum Vitamin D With Psoriasis and Effect Modification by Central Obesity.

Front Med (Lausanne) 2020 18;7:236. Epub 2020 Jun 18.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.

Psoriasis is a chronic recurrent inflammatory disease involving many common mechanisms associated with obesity, such as systemic inflammation and vitamin D deficiency. This study aimed to examine the association of the serum concentration of 25-hydroxyvitamin D with psoriasis and the effect modification by obesity among the affected patients. A mixed cross-section study was conducted. Read More

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http://dx.doi.org/10.3389/fmed.2020.00236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315806PMC

Association between Serum Vitamin D Level and Echocardiographic Abnormalities in Patients with Thalassemia Major.

Cardiovasc Hematol Disord Drug Targets 2020 Jun 30. Epub 2020 Jun 30.

Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran. Iran.

Objectives: Thalassemia major (TM) is one of the most common blood disorders with a high mortality rate due to cardiovascular disease. Vitamin D deficiency has been suggested to implicate in cardiac abnormalities. In this prospective study, we aimed to investigate the relationship between serum levels of vitamin D and tissue Doppler (TD) echocardiographic indices in thalassemia major patients. Read More

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http://dx.doi.org/10.2174/1871529X20666200701104931DOI Listing

Evaluation of Self-Assessed State of Health and Vitamin D Knowledge in Emirati and International Female Students in United Arab Emirates (UAE).

Front Psychol 2020 12;11:1236. Epub 2020 Jun 12.

Department of Hygiene and Epidemiology, Department of Developmental Psychiatry, Psychotic and Geriatric Disorders, Medical University of Gdańsk, Gdańsk, Poland.

Introduction: Globally, vitamin D deficiency is one of the most common deficiencies, affecting nearly half the world's population. The objective of this survey was to assess and compare the knowledge about vitamin D and the perceived state of health in Emirati and international tourist female students in Dubai, United Arab Emirates (UAE).

Methods: This is a cross-sectional study that took place in universities in Dubai, United Arab Emirates. Read More

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http://dx.doi.org/10.3389/fpsyg.2020.01236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303256PMC

Perioperative Serum 25-Hydroxyvitamin D Levels as a Predictor of Postoperative Opioid Use and Opioid Use Disorder: a Cohort Study.

J Gen Intern Med 2020 Jun 24. Epub 2020 Jun 24.

Department of Population Medicine, Harvard Medical School, , 401 Park Drive #401, Boston, MA, 02215, USA.

Importance: Vitamin D deficiency is associated with chronic pain syndromes and higher opioid use among cancer patients, but its association with opioid use among opioid-naïve subjects following a major surgical procedure with acute pain has not been explored.

Objective: To determine the association between serum 25-hydroxyvitamin D (25(OH)D) levels, opioid use, and opioid use disorder.

Methods: We identified commercially insured subjects aged 18-64 years with available perioperative serum 25-hydroxyvitamin D (25D) levels who underwent one of nine major surgical procedures in 2000-2014. Read More

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http://dx.doi.org/10.1007/s11606-020-06001-yDOI Listing

Polycystic Ovary Syndrome, Subfertility and Vitamin D Deficiency.

J Coll Physicians Surg Pak 2020 May;30(5):545-546

Department of Biological and Biomedical Sciences, The Aga khan university, Karachi, Pakistan.

Polycystic ovarian syndrome (PCOS) is the most common endocrine female disorder, affecting 4-18% women of reproductive age. The prevalence of PCOS in South Asian women, especially in Pakistani women, is much higher (52%) as compared to white population (20 - 25% in UK). In Pakistan, vitamin D status displays 31. Read More

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http://dx.doi.org/10.29271/jcpsp.2020.05.545DOI Listing

Determination of vitamin D and analysis of risk factors for osteoporosis in patients with chronic pain.

World J Clin Cases 2020 Jun;8(11):2150-2161

Department of Pain, Qinghai Provincial People's Hospital, Xining 810000, Qinghai Province, China.

Background: Vitamin D deficiency is common in patients with chronic pain and healthy people, but the difference between the two has not been reported; thus, whether there is a relationship between vitamin D deficiency and chronic pain remains to be confirmed. Osteoporosis is a common disease in chronic pain disorders. Understanding the relationship between vitamin D and osteoporosis will provide a basis for the rational supplementation of vitamin D to prevent osteoporosis, and to understand the risk factors of bone mass change to provide a new treatment plan for early prevention of osteoporosis. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i11.2150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281063PMC

Vitamin D deficiency mediates the relationship between dietary patterns and depression: a case-control study.

Ann Gen Psychiatry 2020 3;19:37. Epub 2020 Jun 3.

Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Vakilabad Blv. Azadi Squre, Mashhad, Iran.

Background: Depression is a major contributor to disability-adjusted life years (DALY) lost in the world. Dietary patterns are widely used to investigate diet-disease relations. In the current study, the relationship between dietary patterns and depression was investigated. Read More

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http://dx.doi.org/10.1186/s12991-020-00288-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271480PMC

Genetic Variation in Cytochrome P450 2R1 and Vitamin D Binding Protein Genes are associated with Vitamin D Deficiency in Adolescents.

Int J Vitam Nutr Res 2020 Jun 15;90(3-4):339-345. Epub 2019 Nov 15.

Physiology Department, Applied Physiology Research Center, Isfahan University of Medical Sciences, Iran.

Genome Wide Association Studies (GWAS) have evaluated several genes related to vitamin D synthesis, metabolism and transport. They have proposed a genetic basis for low levels of vitamin D in the blood. The current study aims to investigate the relationship between certain vitamin D-associated gene variants and vitamin D deficiency in Iranian adolescents. Read More

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http://dx.doi.org/10.1024/0300-9831/a000632DOI Listing

Vitamin D-RAAS connection: An Integrative Standpoint into Cardiovascular and Neuroinflammatory Disorders.

Curr Protein Pept Sci 2020 Jun 6. Epub 2020 Jun 6.

Área de Farmacología, Departamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo. Argentina.

Background: The neuroinflammatory process is associated with the pathogenesis of many cardiovascular disorders, particularly with hypertension. In this regard, the deficiency of vitamin D seems to increase the risk of cardiovascular pathologies related to neuroinflammation. Long-term vitamin D lack leads to over-activation of the reninangiotensin-aldosterone system (RAAS), one of the essential mechanisms of blood pressure regulation. Read More

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http://dx.doi.org/10.2174/1389203721666200606220719DOI Listing

Current Therapy in CKD Patients Can Affect Vitamin K Status.

Nutrients 2020 May 30;12(6). Epub 2020 May 30.

Nephrology, Dialysis and Renal Transplant Unit, Department of Experimental Diagnostic and Specialty Medicine (DIMES), S. Orsola Hospital, University of Bologna, 40126 Bologna, Italy.

Chronic kidney disease (CKD) patients have a higher risk of cardiovascular (CVD) morbidity and mortality compared to the general population. The links between CKD and CVD are not fully elucidated but encompass both traditional and uremic-related risk factors. The term CKD-mineral and bone disorder (CKD-MBD) indicates a systemic disorder characterized by abnormal levels of calcium, phosphate, PTH and FGF-23, along with vitamin D deficiency, decreased bone mineral density or altered bone turnover and vascular calcification. Read More

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http://dx.doi.org/10.3390/nu12061609DOI Listing

Vitamin D supplementation for sickle cell disease.

Cochrane Database Syst Rev 2020 05 28;5:CD010858. Epub 2020 May 28.

Comprehensive Sickle Cell Program, Aflac Cancer and Blood Disorders Service, Emory University School of Medicine, Atlanta, Georgia, USA.

Background: Sickle cell disease (SCD) is a genetic chronic haemolytic and pro-inflammatory disorder. With increased catabolism and deficits in energy and nutrient intake, individuals with SCD suffer multiple macro- and micro-nutritional deficiencies, including vitamin D deficiency. This is an update of a previous review. Read More

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http://dx.doi.org/10.1002/14651858.CD010858.pub3DOI Listing

Vitamin D-mitochondria cross-talk could modulate the signaling pathway involved in hypertension development: a translational integrative overview.

Clin Investig Arterioscler 2020 May 23. Epub 2020 May 23.

Laboratorio de Farmacología Experimental Básica y Traslacional, Área de Farmacología, Departamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Centro Universitario, Mendoza, Argentina; Instituto de Medicina y Biología Experimental de Cuyo, Consejo Nacional de Investigación Científica y Tecnológica (IMBECU-CONICET), Mendoza, Argentina. Electronic address:

Vitamin D deficiency is a worldwide pandemic and results in osteoporosis, hypertension, and other cardiovascular diseases. At the cellular level, it produces significant oxidative stress, inflammatory markers, and mitochondrial damage. There is increasing evidence about the role of vitamin D in the regulation of the renin-angiotensin-aldosterone system (RAAS). Read More

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http://dx.doi.org/10.1016/j.arteri.2020.02.002DOI Listing

Vitamin D Effects on the Immune System from Periconception through Pregnancy.

Nutrients 2020 May 15;12(5). Epub 2020 May 15.

Hannover Medical School, Gynaecology Research Unit, Carl-Neuberg-Str.1, D-30625 Hannover, Germany.

Vitamin D is a well-known secosteroid and guardian of bone health and calcium homeostasis. Studies on its role in immunomodulatory functions have expanded its field in recent years. In addition to its impact on human physiology, vitamin D influences the differentiation and proliferation of immune system modulators, interleukin expression and antimicrobial responses. Read More

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http://dx.doi.org/10.3390/nu12051432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284509PMC

Differential Impact of Serum 25-Hydroxyvitamin D3 Levels on the Prognosis of Patients with Liver Cirrhosis According to MELD and Child-Pugh Scores.

J Korean Med Sci 2020 May 18;35(19):e129. Epub 2020 May 18.

Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.

Background: Prognosis of patients with diverse chronic diseases is reportedly associated with 25-hydroxyvitamin D levels. In this study, we investigated the potential role of 25-hydroxyvitamin D3 (25[OH]D3) levels in improving the predictive power of conventional prognostic models for patients with liver cirrhosis.

Methods: We investigated clinical findings, including serum 25(OH)D3 levels at admission, of 155 patients with cirrhosis who were followed up for a median of 16. Read More

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http://dx.doi.org/10.3346/jkms.2020.35.e129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234861PMC

Counter-regulatory 'Renin-Angiotensin' System-based Candidate Drugs to Treat COVID-19 Diseases in SARS-CoV-2-infected patients.

Infect Disord Drug Targets 2020 May 17. Epub 2020 May 17.

Université Aix-Marseille, Institut de Neuro-physiopathologie (INP), UMR 7051, Faculté de Pharmacie, 27 Bd Jean Moulin, 13385 Marseille Cedex. France.

SARS-CoV-2 / COVID-19 and the 'Renin-Angiotensin' System The ubiquitous 'Renin-Angiotensin' system (RAS), also referred to as 'Renin-Angiotensin-Aldosterone' system, plays a crucial physiological role in humans as being a key regulator of renal, cardiovascular and innate immune functions [1, 2]. It appears to work in tandem with vitamin D, a secosteroid pro-hormone which reportedly acts as a negative regulatory factor of the RAS [3-6]. A dysfunction (e. Read More

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http://dx.doi.org/10.2174/1871526520666200518073329DOI Listing

Effect of vitamin D nutrition on disease indices in patients with primary hyperparathyroidism.

J Steroid Biochem Mol Biol 2020 Jul 12;201:105695. Epub 2020 May 12.

Department of Public Helath Sciences Henry Ford Health System One Ford Place Detroit, MI 48202, United States.

In patients with primary hyperparathyroidism, the size of the adenoma is a major determinant of biochemical indices, disease severity, and manner of presentation. However, the large variation in adenoma weight, both within and between populations and a steady decline in parathyroid adenoma weights over time remain largely unexplained. Based on the results in a small number of patients almost two decades ago we proposed that vitamin D nutritional status of the patient explains both the disease manifestations and much of the variation in adenoma size. Read More

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http://dx.doi.org/10.1016/j.jsbmb.2020.105695DOI Listing

Comorbidities of antiphospholipid syndrome and systemic lupus erythematosus in children.

Curr Rheumatol Rep 2020 May 13;22(6):21. Epub 2020 May 13.

Division of Pediatric Rheumatology, Department of Pediatrics, Istanbul Faculty of Medicine, Istanbul University, İstanbul, Turkey.

Purpose Of Review: Antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) are autoimmune diseases that can affect multiple organ systems. Increased awareness and new treatment strategies ultimately improved the survival of patients, and disease-related comorbidities became more important. The purpose of this review is to focus on comorbidities in these diseases that had a negative influence on the course of the disease. Read More

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http://dx.doi.org/10.1007/s11926-020-00899-3DOI Listing

'Scientific Strabismus' or two related pandemics: coronavirus disease and vitamin D deficiency.

Br J Nutr 2020 May 12:1-6. Epub 2020 May 12.

Department of Physical Medicine and Rehabilitation, Hacettepe University Medical School, Ankara, Turkey.

The WHO has announced the novel coronavirus disease (COVID-19) outbreak to be a global pandemic. The distribution of community outbreaks shows seasonal patterns along certain latitude, temperature and humidity, that is, similar to the behaviour of seasonal viral respiratory tract infections. COVID-19 displays significant spread in northern mid-latitude countries with an average temperature of 5–11°C and low humidity. Read More

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http://dx.doi.org/10.1017/S0007114520001749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300194PMC

[12th Post-ECTRIMS Meeting: review of the novelties from the 2019 ECTRIMS Congress (I)].

Rev Neurol 2020 May;70(10):379-390

Hospital de Cruces, Baracaldo, España.

Introduction: Like every year, after the ECTRIMS Congress, renowned Spanish neurologists who are experts in multiple sclerosis presented the main novelties in research in this field at the Post-ECTRIMS Meeting.

Aim: To summarise the content presented at the 12th edition of the Post-ECTRIMS Meeting, which took place in September 2019 in Sevilla and is presented in two parts.

Development: This first part addresses the latest studies on vitamin D deficiency and the discrepancies that currently exist regarding its treatment. Read More

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http://dx.doi.org/10.33588/rn.7010.2020121DOI Listing

THE RELATIONSHIP BETWEEN TYPE-2 DIABETES AND TUBERCULOSIS.

Georgian Med News 2020 Mar(300):69-74

National Center for Tuberculosis and Lung Diseases; I. Javakhishvili State University; European University, Tbilisi State Medical University, Georgia.

According to the experimental and clinical investigations, innate and adaptive immune disorders play a significant role in T2-D subjects to become more susceptible to TB. It was shown that the functions of neutrophils, macrophages, NK cells and other components of innate immunity areis markedly compromised by metabolic disorders in T2-D. The number of evidences suggests that reduction in TH1:TH2 cytokines ratios may have significant influence on susceptibility of TB infection in T2-D subjects. Read More

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Maternal Vitamin D and its Role in Determining Fetal Origins of Mental Health.

Curr Pharm Des 2020 ;26(21):2497-2509

Chair of Psychiatry, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.

There is evidence that mental health disorders may have roots in fetal life and are associated with deficiencies in various micronutrients, including vitamin D. During pregnancy, vitamin D balance is influenced by an increase in maternal calcitriol and a substantial increase in maternal Vitamin D Binding Protein concentrations. In the early stages of life, vitamin D is necessary to mediate numerous brain processes such as proliferation, apoptosis, and neurotransmission. Read More

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http://dx.doi.org/10.2174/1381612826666200506093858DOI Listing
January 2020

Vitamin D deficiency is not associated with graft versus host disease after hematopoietic stem cell transplantation: A meta-analysis.

J Evid Based Med 2020 May 5. Epub 2020 May 5.

King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.

Objective: Vitamin D status plays an important role in immunoregulation, and a deficiency is believed to be related to Graft Versus Host Disease (GVHD) in patients after hematopoietic stem cell transplantation (HSCT). We aim to study the association between vitamin D deficiency and GVHD after HSCT.

Methods: A literature search was conducted utilizing MEDLINE, EMBASE, and The Cochrane Library Database from inception to July 2019. Read More

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http://dx.doi.org/10.1111/jebm.12383DOI Listing

Vitamin D deficiency is associated with respiratory symptoms and airway wall thickening in smokers with and without COPD: a prospective cohort study.

BMC Pulm Med 2020 May 4;20(1):123. Epub 2020 May 4.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA, 02115, USA.

Background: Previous studies have established a higher prevalence of vitamin D deficiency in patients with COPD, but the relationship between vitamin D levels and COPD exacerbations remains controversial. In addition, the effect of vitamin D levels on imaging characteristics remains mostly unexplored. Using cross-sectional and longitudinal follow up data from the COPDGene Study, we assessed the association between vitamin D levels on respiratory symptoms, exacerbations, and imaging characteristics. Read More

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http://dx.doi.org/10.1186/s12890-020-1148-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199369PMC

Zoledronate.

Bone 2020 Aug 27;137:115390. Epub 2020 Apr 27.

Department of Clinical Medicine, University of Oslo, Oslo, Norway.

Zoledronate is the most potent and most long-acting bisphosphonate in clinical use, and is administered as an intravenous infusion. Its major uses are in osteoporosis, Paget's disease, and in myeloma and cancers to reduce adverse skeletal related events (SREs). In benign disease, it is a first- or second-line treatment for osteoporosis, achieving anti-fracture efficacy comparable to that of the RANKL blocker, denosumab, over 3 years, and it reduces fracture risk in osteopenic older women. Read More

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http://dx.doi.org/10.1016/j.bone.2020.115390DOI Listing

Novel Insights into the Pathogenesis of Spinal Sarcopenia and Related Therapeutic Approaches: A Narrative Review.

Int J Mol Sci 2020 Apr 24;21(8). Epub 2020 Apr 24.

Department of Orthopedics, Taipei Medical University Hospital, Taipei 11031, Taiwan.

Spinal sarcopenia is a complex and multifactorial disorder associated with a loss of strength, increased frailty, and increased risks of fractures and falls. In addition, spinal sarcopenia has been associated with lumbar spine disorders and osteoporosis, which renders making decisions on treatment modalities difficult. Patients with spinal sarcopenia typically exhibit lower cumulative survival, a higher risk of in-hospital complications, prolonged hospital stays, higher postoperative costs, and higher rates of blood transfusion after thoracolumbar spine surgery. Read More

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http://dx.doi.org/10.3390/ijms21083010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216136PMC

Hypocalcemia following Neridronate Administration in Pediatric Patients with Osteogenesis Imperfecta: A Prospective Observational Study.

J Pediatr Genet 2020 Jun 6;9(2):93-100. Epub 2020 Jan 6.

Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, Regional Center for the Diagnosis and Treatment of Children and Adolescents with Rare Skeletal Disorders, Pediatric Clinic, University of Verona, Verona, Italy.

The use of intravenous bisphosphonates has been linked to hypocalcemia both in children and adults with osteogenesis imperfecta (OI). The aims of this study were: (1) to investigate the incidence of hypocalcemia in the first 48 hours (T48) after neridronate infusion in a pediatric population with OI and (2) to assess any correlation between the baseline values of calcium, vitamin D (25-hydroxyvitamin D) and bone turnover markers, and the postinfusion calcium values. We conducted a prospective observational study on 37 pediatric patients. Read More

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http://dx.doi.org/10.1055/s-0039-1700972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183406PMC

Molecular and cellular mechanisms linking air pollution and bone damage.

Environ Res 2020 Jun 6;185:109465. Epub 2020 Apr 6.

Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, 10032, USA. Electronic address:

Air pollution is the second most important risk factor associated with noncommunicable diseases after smoking. The effects of pollution on health are commonly attributable to particulate matter (PM), a complex mixture of particles suspended in the air. PM can penetrate the lower respiratory tract and has harmful direct and indirect effects on different organs and tissues. Read More

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http://dx.doi.org/10.1016/j.envres.2020.109465DOI Listing

Vitamin D, calcium or a combination of vitamin D and calcium for the treatment of nutritional rickets in children.

Cochrane Database Syst Rev 2020 04 17;4:CD012581. Epub 2020 Apr 17.

University of Calabar Teaching Hospital, Department of Paediatrics, PMB 1115, Calabar, Cross River State, Nigeria.

Background: Nutritional rickets is a disease which affects children, especially in low- and middle-income countries. It causes problems such as skeletal deformities and impaired growth. The most common cause of nutritional rickets is vitamin D deficiency. Read More

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http://dx.doi.org/10.1002/14651858.CD012581.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164979PMC

Association study between genetic variants in vitamin D metabolism related genes and childhood autism spectrum disorder.

Metab Brain Dis 2020 Aug 15;35(6):971-978. Epub 2020 Apr 15.

Department of Internal Medicine, Zhejiang Xiaoshan Hospital, 311202, Hangzhou, Zhejiang, China.

Vitamin D deficiency has been implicated as a risk factor for autism spectrum disorder (ASD). This case-controlled study was to determine the association between single nucleotide polymorphisms (SNPs) in genes encoding vitamin D metabolism related enzymes and childhood ASD in a Chinese Han population. Both autistic children and age-and gender-matched healthy controls were recruited from September 2012-November 2017. Read More

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http://dx.doi.org/10.1007/s11011-020-00570-xDOI Listing
August 2020
2.638 Impact Factor

Prevalence of Vitamin-D deficiency is related to severity of liver damage in Hepatitis-C patients.

Pak J Med Sci 2020 Mar-Apr;36(3):445-450

Dr. Aftab Islam, MBBS. Medical Practitioner, Dar-us-Shifa Clinic, Faisalabad-38040, Pakistan.

Objective: Serum Vitamin-D plays pivotal role in inflammatory and infectious diseases; among them liver infections are more distinct. This study was aimed to determine Vitamin-D status in HCV-infected patients and healthy controls in Faisalabad, Pakistan.

Methods: We performed randomized cross-sectional study of 74 individuals from 20 August, 2017 to 20 February 2018 at The University of Faisalabad and Dar us Shifa Clinic, Faisalabad. Read More

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http://dx.doi.org/10.12669/pjms.36.3.1490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150413PMC

Screening and Treatment of Vitamin D Deficiency in UK Patients with Crohn's Disease: Self-Reported Practice among Gastroenterologists.

Nutrients 2020 Apr 11;12(4). Epub 2020 Apr 11.

Gastroenterology, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham, Edgbaston, Birmingham B15 2TH, UK.

Currently, there is no UK national recommendation to measure vitamin D levels in patients with inflammatory bowel diseases (IBD). Patients with IBD are at risk of developing vitamin D deficiency with the highest prevalence frequently reported in those with Crohn's disease (CD). Treating vitamin D deficiency as part of CD management continues to be of interest. Read More

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http://dx.doi.org/10.3390/nu12041064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230977PMC

Bone Metabolism and Vitamin D Implication in Gastroenteropancreatic Neuroendocrine Tumors.

Nutrients 2020 Apr 8;12(4). Epub 2020 Apr 8.

Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy.

Patients affected by gastroenteropancreatic-neuroendocrine tumors (GEP-NETs) have an increased risk of developing osteopenia and osteoporosis, as several factors impact on bone metabolism in these patients. In fact, besides the direct effect of bone metastasis, bone health can be affected by hormone hypersecretion (including serotonin, cortisol, and parathyroid hormone-related protein), specific microRNAs, nutritional status (which in turn could be affected by medical and surgical treatments), and vitamin D deficiency. In patients with multiple endocrine neoplasia type 1 (MEN1), a hereditary syndrome associated with NET occurrence, bone damage may carry other consequences. Read More

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http://dx.doi.org/10.3390/nu12041021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230756PMC

The Effect of Vitamin D Supplementation on Serum and Muscle Irisin Levels, and FNDC5 Expression in Diabetic Rats.

Rep Biochem Mol Biol 2019 Oct;8(3):236-243

Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

Background: Diabetes mellitus and metabolic disorders are a major burden on the healthcare system. Irisin is a novel myokine reported to have beneficial effects on glucose and lipid metabolism. Vitamin D deficiency has been implicated in the development of diabetes and hold a critical role in diabetes-related complications. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103079PMC
October 2019

Age-related Smell and Taste Impairments and Vitamin D Associations in the U.S. Adults National Health and Nutrition Examination Survey.

Authors:
Galya Bigman

Nutrients 2020 Apr 2;12(4). Epub 2020 Apr 2.

Division of Epidemiology and Prevention, Institute of Human Virology, University of Maryland School of Medicine, Baltimore City, MD 21201, USA.

Smell and taste decline with aging, and markedly deteriorate when nutritional deficiencies occur. This study aims to examine the associations between Vitamin D (VD) deficiency and smell and taste impairments among adults. This paper details a cross-sectional study utilizing data from the US National Health and Nutrition Examination Survey (NHANES, 2013-2014. Read More

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http://dx.doi.org/10.3390/nu12040984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230220PMC

Genetic predisposition for vitamin D deficiency is not associated with adverse outcome of very low birth weight infants: A cohort study from the German Neonatal Network.

PLoS One 2020 31;15(3):e0230426. Epub 2020 Mar 31.

Department of Pediatrics, University of Lübeck, Lübeck, Germany.

Objective: Postnatal vitamin D supplementation is standard of care in neonates and preterm infants. Despite routine supplementation of vitamin D, a wide range of complications related to vitamin D deficiency has been described in the literature. Since standard vitamin D supplementation might be not sufficient in preterm infants with a genetic predisposition for vitamin D deficiency, we investigated the outcome of preterm infants with regard to their genetic estimated vitamin D levels. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230426PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108707PMC

Effects of sunlight exposure and vitamin D supplementation on HIV patients.

J Steroid Biochem Mol Biol 2020 Jun 27;200:105664. Epub 2020 Mar 27.

Department of Pathology, Lake Erie College of Osteopathic Medicine, Erie, PA, USA. Electronic address:

Unlike many vitamins derived predominantly from food sources, vitamin D is produced endogenously in the skin upon exposure to sunlight. Ethnicity, skin pigmentation, socioeconomic status, geographic location, climate and sunscreen; all of these factors contribute to the amount of insolation for any given individual. Insufficient insolation creates the prerequisites for vitamin D deficiency. Read More

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http://dx.doi.org/10.1016/j.jsbmb.2020.105664DOI Listing

Vitamin D Supplementation in Multiple Sclerosis: A Critical Analysis of Potentials and Threats.

Nutrients 2020 Mar 16;12(3). Epub 2020 Mar 16.

Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria.

Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system (CNS). In recent years, vitamin D has gained attention, as low serum levels are suspected to increase the risk for MS. Cholecalciferol supplementation has been tested in several clinical trials, since hypovitaminosis D was linked to higher disease activity and may even play a role in long-term outcome. Read More

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http://dx.doi.org/10.3390/nu12030783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146466PMC

Vitamin D Deficiency and Rheumatoid Arthritis: Epidemiological, Immunological, Clinical and Therapeutic Aspects.

Mediterr J Rheumatol 2019 Jun 29;30(2):94-102. Epub 2019 Jun 29.

Mobility Impairment Research Center; Babol University of Medical Sciences, Babol, Islamic Republic of Iran.

Background/aim: Vitamin D displays an immunologic effect which can modulate function of Th17-related cytokines and thereby prevent perpetuation of inflammation in chronic disorders like rheumatoid arthritis (RA). This review aims to conduct a literature review to provide a summary of recent studies addressing the relationship between vitamin D deficiency and RA based on epidemiological, immunological and therapeutic aspects.

Methods: PubMed, Scopus and Google scholar were searched for relevant papers published between 2000-2018. Read More

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http://dx.doi.org/10.31138/mjr.30.2.94DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045965PMC

Consensus statement from 2 International Conference on Controversies in Vitamin D.

Rev Endocr Metab Disord 2020 03;21(1):89-116

Department of Medicine, Endocrinology Division, College of Physicians and Surgeons, Columbia University, New York, NY, USA.

The 2 International Conference on Controversies in Vitamin D was held in Monteriggioni (Siena), Italy, September 11-14, 2018. The aim of this meeting was to address ongoing controversies and timely topics in vitamin D research, to review available data related to these topics and controversies, to promote discussion to help resolve lingering issues and ultimately to suggest a research agenda to clarify areas of uncertainty. Several issues from the first conference, held in 2017, were revisited, such as assays used to determine serum 25-hydroxyvitamin D [25(OH)D] concentration, which remains a critical and controversial issue for defining vitamin D status. Read More

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http://dx.doi.org/10.1007/s11154-019-09532-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113202PMC

Vitamin D levels are prognostic factors for connective tissue disease associated interstitial lung disease (CTD-ILD).

Aging (Albany NY) 2020 03 12;12(5):4371-4378. Epub 2020 Mar 12.

Department of Respiratory and Critical Care Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu, China.

Objective: Vitamin D deficiency was associated with CTD-ILD and reduced lung function. We sought to confirm that lower Vitamin D level would be related to shorter survival times.

Results: The CTD-ILD patients had lower Vitamin D level(P<0. Read More

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http://dx.doi.org/10.18632/aging.102890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093159PMC

High-Dose Vitamin D-Mediated Hypercalcemia as a Potential Risk Factor in Central Nervous System Demyelinating Disease.

Front Immunol 2020 25;11:301. Epub 2020 Feb 25.

Department of Neuropathology, Institute of Neuropathology, University Medical Center, Göttingen, Germany.

The exact cause of multiple sclerosis (MS) is unknown; however, it is considered to be an inflammatory disease of the central nervous system (CNS) triggered by a combination of both environmental and genetic factors. Vitamin D deficiency is also discussed as a possible disease-promoting factor in MS, as low vitamin D status is associated with increased formation of CNS lesions, elevated number of relapses and accelerated disease progression. However, it remains unclear whether this association is causal and related and most importantly, whether vitamin D supplementation in MS is of direct therapeutic benefit. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053380PMC
February 2020

Vitamin D supplementation and pain-related emergency department visits in children with sickle cell disease.

Complement Ther Med 2020 Mar 15;49:102342. Epub 2020 Feb 15.

Developmental Neurosciences, UCL Great Ormond Street Institute of Child Health, London, United Kingdom; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States; Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.

Objectives: Sickle cell disease (SCD) is the most prevalent inherited hematological disorder and affects 100,000 individuals in the United States. Pain is the most common cause of emergency department (ED) visits in the SCD population, which profoundly affects quality of life. Vitamin D supplementation is a potential target for reducing pain. Read More

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http://dx.doi.org/10.1016/j.ctim.2020.102342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076737PMC
March 2020
2.216 Impact Factor

Vitamin D deficiency and its association with fatigue and quality of life in multiple sclerosis patients.

EPMA J 2020 Mar 20;11(1):65-72. Epub 2019 Nov 20.

Department of Neurology, Medical Faculty, İzmir Katip Celebi University, İzmir, Turkey.

Background: Vitamin D deficiency is associated with the incidence and prevalence of a variety of neurologic disorders, including multiple sclerosis. However, available studies to date have not provided convincing evidence that vitamin D treatment improves fatigue and life quality in patients with multiple sclerosis.

Aim: To assess the relationship of vitamin D deficiency with health-related quality-of-life issues and fatigue in multiple sclerosis patients. Read More

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http://dx.doi.org/10.1007/s13167-019-00191-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028884PMC

Determinants of High Parathyroid Hormone Levels in Patients With Severe Obesity and Their Relationship With the Cardiometabolic Risk Factors, Before and After a Laparoscopic Sleeve Gastrectomy Intervention.

Obes Surg 2020 Jun;30(6):2225-2232

Dipartimento di Medicina, Università degli Studi di Perugia, Perugia, Italy.

Background: Obesity is a risk factor for vitamin D deficiency and hyperparathyroidism. Hyperparathyroidism could exert a negative effect on glucose metabolism and vascular function. The aim of this study was to identify the determinants of hyperparathyroidism beyond vitamin D deficiency, whether hyperparathyroidism could have a negative impact on individual health and whether laparoscopic sleeve gastrectomy (LSG) negatively affects the levels of intact parathyroid hormone (iPTH) and 25(OH) vitamin D (25(OH)D). Read More

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http://dx.doi.org/10.1007/s11695-020-04453-zDOI Listing

Sirtuin-1 and Its Relevance in Vascular Calcification.

Int J Mol Sci 2020 Feb 26;21(5). Epub 2020 Feb 26.

Division of Nephrology, Department of Medicine, Fu Jen Catholic University Hospital, School of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan.

Vascular calcification (VC) is highly associated with cardiovascular disease and all-cause mortality in patients with chronic kidney disease. Dysregulation of endothelial cells and vascular smooth muscle cells (VSMCs) is related to VC. Sirtuin-1 (Sirt1) deacetylase encompasses a broad range of transcription factors that are linked to an extended lifespan. Read More

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http://dx.doi.org/10.3390/ijms21051593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084838PMC
February 2020

Graves' disease: Epidemiology, genetic and environmental risk factors and viruses.

Best Pract Res Clin Endocrinol Metab 2020 Jan 4;34(1):101387. Epub 2020 Feb 4.

Department of Translational Research of New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy. Electronic address:

Graves' disease (GD) is the most common cause of hyperthyroidism in developed Countries. It is more common between 30 and 60 years; 5-10 times more frequent in women. The genetic predisposition accounts for 79% of the risk for GD, while environmental factors for 21%. Read More

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http://dx.doi.org/10.1016/j.beem.2020.101387DOI Listing
January 2020

Pathological fracture of the femur in Alagille Syndrome: A case report.

J Clin Orthop Trauma 2020 Mar-Apr;11(2):298-301. Epub 2019 Dec 19.

Department of Orthopaedic and Traumatology, Faculty of Medicine, Udayana University, P.B. Sudirman Street, Denpasar Bali, Indonesia.

Alagille Syndrome is a rare autosomal dominant genetic disorder, occur only 1:70,000 in population, and characterized by reduced interlobular bile ducts, and resultant nutritional deficiencies associated with the inability to absorb fat-soluble vitamins such as vitamin D. Patients are at risk for secondary osteoporosis, rickets/osteomalacia, and ultimately may result in fracture. The majority of patients suffer from chronic cholestasis, which can have a variety of adverse effects on bone metabolism. Read More

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http://dx.doi.org/10.1016/j.jcot.2019.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026569PMC
December 2019

Efficient synthesis of 3-TBDMS-11α,25-dihydroxyvitamin D and D ethers.

J Steroid Biochem Mol Biol 2020 Jun 22;200:105638. Epub 2020 Feb 22.

Endotherm Life Science Molecules, 66123 Saarbruecken, Germany.

Vitamin D deficiency might cause a wide variety of human disorders. As a prerequisite for appropriate diagnosis and therapy, medicinally relevant vitamin D metabolites have to be assayed most accurately and with high specificity. It has been demonstrated, that vitamin D conjugates, linked via a hydroxyl group at C11, might be promising for the development of highly specific antibodies to be employed in competitive protein binding assays. Read More

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http://dx.doi.org/10.1016/j.jsbmb.2020.105638DOI Listing

Relationship between plasma levels of 25-hydroxyvitamin D and arterial stiffness in elderly Chinese with non-dipper hypertension: An observational study.

Medicine (Baltimore) 2020 Feb;99(7):e19200

Department of Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong City.

Elderly individuals with non-dipper hypertension are at high risk of cardiovascular disease because of increased stiffness of peripheral arteries. Since, vitamin D deficiency is prevalent in elderly Chinese. We examined whether reduced plasma levels of 25-hydroxyvitamin D [25(OH)D] may help promote this stiffness. Read More

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http://dx.doi.org/10.1097/MD.0000000000019200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035115PMC
February 2020