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    1352 results match your criteria Vitamin D Deficiency and Related Disorders

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    Association between mental disorders, cognitive disturbances and vitamin D serum level: Current state.
    Clin Nutr ESPEN 2018 Feb 23;23:89-102. Epub 2017 Dec 23.
    Be'er Sheva Mental Health Center, Faculty of Health Sciences Ben-Gurion University of the Negev, Be'er Sheva, Israel. Electronic address:
    Background & Aims: Vitamin D deficiency has been identified as a global problem. Approximately 14% of the world population has inadequate vitamin D levels. This vitamin has been usually associated with bone disorders such as rickets, osteomalacia, and osteoporosis. Read More

    The importance of vitamin D in maternal and child health: a global perspective.
    Public Health Rev 2017 1;38:19. Epub 2017 Sep 1.
    1Institute of Endocrinology, The Children's Hospital at Westmead, Corner Hawkesbury Road and Hainsworth Street, Locked Bag 4001, Westmead, NSW 2145 Australia.
    Vitamin D and calcium are important nutrients for skeletal growth and bone health. Children and pregnant women are particularly vulnerable to 25-hydroxy vitamin D deficiency (VDD). VDD, with or without dietary calcium deficiency, can lead to nutritional rickets (NR), osteomalacia, and disturbances in calcium homeostasis. Read More

    Normocalcaemic primary hyperparathyroidism: a pragmatic approach.
    J Clin Pathol 2018 Feb 3. Epub 2018 Feb 3.
    Wolverhampton Endocrine and Diabetes Unit, New Cross Hospital, Wolverhampton, UK.
    It is well recognised that over the past three to four decades the incidence of asymptomatic primary hyperparathyroidism has increased significantly. However, more recently this pattern has further evolved into a presentation with normocalcaemia and raised parathyroid hormone (PTH) level without the presence of a recognised stimulus for its rise, in the form of vitamin D deficiency or renal impairment. A diagnostic label of normocalcaemic hyperparathyroidism (NPHPT) has been given to this phenotype and in most such individuals, the initial PTH measurement is driven by the presence of metabolic bone disease. Read More

    Medical findings in 1,026 consecutive adult inpatient-residential eating disordered patients.
    Int J Eat Disord 2018 Feb 8. Epub 2018 Feb 8.
    Eating Recovery Center, Denver, Denver, Colorado.
    Objective: Eating disorders are associated with multiple medical complications. We report contemporary medical data, for newly admitted adult inpatient and residential level of care patients.

    Method: Medical records of a transdiagnostic sample of 1,026 patients, with eating disorders, were retrospectively reviewed for the presence of a broad array of medical complications at time of admission. Read More

    Vitamin D deficiency and hepatitis viruses-associated liver diseases: A literature review.
    World J Gastroenterol 2018 Jan;24(4):445-460
    Molecular Genetics of Infectious Diseases, Institute of Tropical Medicine, University of Tübingen, Tübingen 72074, Germany.
    The secosteroid hormone vitamin D has, in addition to its effects in bone metabolism also functions in the modulation of immune responses against infectious agents and in inhibiting tumorigenesis. Thus, deficiency of vitamin D is associated with several malignancies, but also with a plethora of infectious diseases. Among other communicable diseases, vitamin D deficiency is involved in the pathogenesis of chronic liver diseases caused by hepatitis B and C viruses (HBV, HCV) and high prevalence of vitamin D deficiency with serum levels below 20 mg/mL in patients with HBV and HCV infection are found worldwide. Read More

    PTH, vitamin D, and the FGF-23-klotho axis and heart: Going beyond the confines of nephrology.
    Eur J Clin Invest 2018 Feb 2. Epub 2018 Feb 2.
    Cardiorenal Translational Laboratory, Institute of Research i+12, Hospital Universitario de Octubre/CIBERCV, Madrid, Spain.
    Background: Profound disturbances in mineral metabolism are closely linked to the progression of chronic kidney disease. However, increasing clinical and experimental evidence indicates that alterations in phosphate homoeostasis could have an even stronger impact on the heart.

    Aim: The aim of this review is to provide the reader with an update of how alterations in mineral metabolism are related to direct and indirect cardiotoxic effects beyond the nephrology setting. Read More

    Postpartum depression and vitamin D: A systematic review.
    Crit Rev Food Sci Nutr 2018 Feb 2:1-7. Epub 2018 Feb 2.
    c Food Security Research Center, Isfahan University of Medical Sciences , Isfahan , Iran.
    Postpartum depression (PPD) is a prevalent mood disorder estimated to affect 20%-40% of women worldwide after childbirth. In recent studies, the effect of vitamin D on prevention of mood disorders and depression has been investigated, but it is still unclear how vitamin D may affect PPD. The evidence on the relevance between vitamin D deficiency and PPD is inconsistent, and assessment of the recent literature has not previously been carried out. Read More

    5α-dihydrotestosterone reduces renalexpressionsuppression of progesterone receptor.
    J Mol Endocrinol 2018 Feb;60(2):159-170
    College of Veterinary MedicineChungnam National University, Daejeon, Republic of Korea
    Androgens act in concert with vitamin D to influence reabsorption of calcium. However, it is unclear whether androgens directly regulate vitamin D homeostasis or control other cellular events that are related to vitamin D metabolism. To examine whether the expression of vitamin D-related genes in mouse kidney is driven by androgens or androgen-dependent effects, the androgen receptor and other sex steroid receptors were monitored in orchidectomized mice treated with 5α-dihydrotestosterone (DHT). Read More

    Analytical Methods for Quantification of Vitamin D and Implications for Research and Clinical Practice.
    Anticancer Res 2018 02;38(2):1137-1144
    Institute of Bioanalytical Chemistry, Saarland University, Saarbrücken, Germany
    A plethora of contradictory research surrounds vitamin D and its influence on health and disease. This may, in part, result from analytical difficulties with regard to measuring vitamin D metabolites in serum. Indeed, variation exists between analytical techniques and assays used for the determination of serum 25-hydroxyvitamin D. Read More

    Investigating the bone mineral density in children with solid tumors in southern Iran: a case-control study.
    Arch Osteoporos 2018 Jan 26;13(1). Epub 2018 Jan 26.
    Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, IR, Iran.
    Along with increasing childhood cancer survival, there is increasing concern about its chronic complications. We showed that 20.5 and 45. Read More

    Vitamin D deficiency and its relationship with cardiac iron and function in patients with transfusion-dependent thalassemia at Chiang Mai University Hospital.
    Pediatr Hematol Oncol 2018 Jan 23:1-8. Epub 2018 Jan 23.
    a Department of Pediatrics , Faculty of Medicine, Chiang Mai University , Chiang Mai , Thailand.
    Background: Vitamin D deficiency is common in patients with thalassemia. Vitamin D deficiency could be related to cardiac dysfunction. Increased parathyroid hormone (PTH) is also known to be associated with heart failure. Read More

    Vitamin D and juvenile systemic lupus erythematosus: Lights, shadows and still unresolved issues.
    Autoimmun Rev 2018 Jan 22. Epub 2018 Jan 22.
    Institute of Pediatrics, Fondazione Policlinico Universitario "A. Gemelli", Università Cattolica Sacro Cuore, Rome, Italy.
    Systemic lupus erythematosus (SLE) and juvenile SLE (jSLE) are autoimmune disorders naturally associated with several genetic, environmental, hormonal, and immunological contributing factors. It has been assumed that vitamin D deficiency may have a role in the immune activation of patients with SLE and play an active part in many comorbidities and even complications. A host of clinical studies suggested that vitamin D exerts inhibitory effects on many immunological abnormalities associated with SLE, also in children and adolescents, while different reports have hypothesized that vitamin D may be associated with accelerated cardiovascular disease in SLE. Read More

    Hypercalcaemic Pancreatitis, Adrenal Insufficiency, Autoimmune Thyroiditis and Diabetes Mellitus in a girl with Probable Sarcoidosis.
    Int J Endocrinol Metab 2017 Oct 22;15(4):e57199. Epub 2017 Aug 22.
    Department of Paediatric Endocrinology, Alder Hey Children's Hospital, Liverpool, UK.
    Introduction: Sarcoidosis is a multisystemic granulomatous disease with diverse and often non-specific symptoms during childhood. The clinical manifestations sometimes include endocrinopathies related to sarcoid infiltration of various endocrine organs, but more commonly due to the associated autoimmune endocrine disorders. There are only a few reports of multiple autoimmune and non-autoimmune endocrine problems occurring simultaneously in patients with sarcoidosis. Read More

    Vitamin D and Nonalcoholic Fatty Liver Disease: Bi-directional Mendelian Randomization Analysis.
    EBioMedicine 2018 Feb 9;28:187-193. Epub 2018 Jan 9.
    Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China. Electronic address:
    Background: Vitamin D deficiency is associated with nonalcoholic fatty liver disease (NAFLD) in many cross-sectional studies. However, the causality between them has not been established. We used bi-directional mendelian randomization (MR) analysis to explore the causal relationship between 25-hydroxyvitamin D [25(OH)D] and NAFLD. Read More

    Iron, Hematological Parameters and Blood Plasma Lipid Profile in Vitamin D Supplemented and Non-Supplemented Young Soccer Players Subjected to High-Intensity Interval Training.
    J Nutr Sci Vitaminol (Tokyo) 2017 ;63(6):357-364
    Department of Health Promotion, Gdansk University of Physical Education and Sport.
    Vitamin D deficiency has been associated with increased risk for cardiovascular disease and anemia. Vitamin D-related changes in lipid profile have been studied extensively but the relationship between vitamin D and lipid metabolism is not completely understood. As both vitamin D and intermittent training may potentially affect iron and lipid metabolism, the aim of the study was to evaluate whether a daily supplementation of vitamin D can modulate the response of hematological and lipid parameters to high-intensity interval training (HIIT) in soccer players. Read More

    Pattern Of Dyslipidaemia And Its Association With Hypovitaminosis D In Type 2 Diabetes Mellitus.
    J Ayub Med Coll Abbottabad 2017 Oct-Dec;29(4):604-609
    Sir Syed College of Medical Sciences, Karachi, Pakistan.
    Background: Macrovascular atherosclerosis is an important long-term complication of type 2 diabetes mellitus. Concurrent dyslipidaemia acts as an additional risk factor for these complications. Hypovitaminosis D has been associated with adverse cardiovascular events. Read More

    Vitamin D and the Pathophysiology of Inflammatory Skin Diseases.
    Skin Pharmacol Physiol 2018 Jan 6;31(2):74-86. Epub 2018 Jan 6.
    Research Department, Division of Translational Medicine, Sidra Medicine, Doha, Qatar.
    Background: Vitamin D is a secosteroid, which was initially known for its skeletal role; however, in recent years, its functions in different organs have been increasingly recognized. In this review, we will provide an overview of vitamin D functions in the skin physiology with specific focus on its role in certain inflammatory skin conditions such as psoriasis and atopic dermatitis.

    Methods: A comprehensive literature search was carried out in PubMed and Google Scholar databases using keywords like "vitamin D," "skin," "atopic dermatitis," and "psoriasis. Read More

    World-wide research architecture of vitamin D research: density-equalizing mapping studies and socio-economic analysis.
    Nutr J 2018 Jan 6;17(1). Epub 2018 Jan 6.
    Division of Preventive Medicine, Institute of Occupational Medicine, Social Medicine and Environmental Medicine, Goethe-University, Frankfurt, Germany.
    Background: Despite the numerous associations of vitamin D with health and disease, vitamin D deficiency is still common from a global perspective. While basic research, clinical and preventive activities grow constantly in vitamin D research, there is no in-depth analysis of the related global scientific productivity available so far.

    Methods: Density equalizing mapping procedures (DEMP) were combined with socioeconomic benchmarks using the NewQIS platform. Read More

    Celiac Disease in Patients with Cystic Fibrosis-Related Bone Disease.
    Case Rep Endocrinol 2017 2;2017:2652403. Epub 2017 Nov 2.
    Pulmonary Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
    Both cystic fibrosis (CF) and celiac disease can cause low bone mineral density (BMD) and fractures. Celiac disease may occur at a higher frequency in patients with CF than the general population, and symptoms of these conditions may overlap. We report on two patients presenting with CF-related bone disease in the past year who were subsequently found to have concurrent celiac disease. Read More

    Impact of vitamin D on pregnancy-related disorders and on offspring outcome.
    J Steroid Biochem Mol Biol 2017 Nov 21. Epub 2017 Nov 21.
    Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany; Institute for Laboratory Medicine, IFLB, Berlin, Germany; Department of Basic Medicine, Medical College of Hunan Normal University, Changsha, China. Electronic address:
    Observational studies from all over the world continue to find high prevalence rates of vitamin D insufficiency and deficiency in many populations, including pregnant women. Beyond its classical function as a regulator of calcium and phosphate metabolism, vitamin D elicits numerous effects in the human body. Current evidence highlights a vital role of vitamin D in mammalian gestation. Read More

    Vitamin D and Neurological Diseases: An Endocrine View.
    Int J Mol Sci 2017 Nov 21;18(11). Epub 2017 Nov 21.
    Division of General Medicine, IRCCS Istituto Auxologico Italiano, Ospedale S. Giuseppe, Via Cadorna 90, 28824 Piancavallo VB, Italy.
    Vitamin D system comprises hormone precursors, active metabolites, carriers, enzymes, and receptors involved in genomic and non-genomic effects. In addition to classical bone-related effects, this system has also been shown to activate multiple molecular mediators and elicit many physiological functions. In vitro and in vivo studies have, in fact, increasingly focused on the "non-calcemic" actions of vitamin D, which are associated with the maintenance of glucose homeostasis, cardiovascular morbidity, autoimmunity, inflammation, and cancer. Read More

    New insights into the role of vitamin D in hepatocellular carcinoma.
    Expert Rev Gastroenterol Hepatol 2018 Mar 21;12(3):287-294. Epub 2017 Nov 21.
    a Center of Infectious Diseases , West China Hospital of Sichuan University , Chengdu , China.
    Introduction: In addition to being crucial for host immune defense, vitamin D is involved in cell proliferation, apoptosis, differentiation, inflammation, invasion and metastasis, angiogenesis and micro-RNA modulation. To date, clinical studies have demonstrated that vitamin D deficiency is common not only in patients with chronic liver diseases but also in those with hepatocellular carcinoma (HCC). Experimental studies have also demonstrated that vitamin D and its receptors are related to the occurrence of HCC and the prognoses of patients with HCC. Read More

    Recessive VARS2 mutation underlies a novel syndrome with epilepsy, mental retardation, short stature, growth hormone deficiency, and hypogonadism.
    Hum Genomics 2017 Nov 14;11(1):28. Epub 2017 Nov 14.
    Department of Genetics, King Faisal Specialist Hospital and Research Centre, MBC 03, PO Box 3354, Riyadh, 11211, Saudi Arabia.
    Background: Most mitochondrial and cytoplasmic aminoacyl-tRNA synthetases (aaRSs) are encoded by nuclear genes. Syndromic disorders resulting from mutation of aaRSs genes display significant phenotypic heterogeneity. We expand aaRSs-related phenotypes through characterization of the clinical and molecular basis of a novel autosomal-recessive syndrome manifesting severe mental retardation, ataxia, speech impairment, epilepsy, short stature, microcephaly, hypogonadism, and growth hormone deficiency. Read More

    Vitamin D supplementation for chronic liver diseases in adults.
    Cochrane Database Syst Rev 2017 11 3;11:CD011564. Epub 2017 Nov 3.
    Department of Internal Medicine, Medical Faculty, University of Nis, Zorana Djindjica 81, Nis, Serbia, 18000.
    Background: Vitamin D deficiency is often reported in people with chronic liver diseases. Therefore, improving vitamin D status could have a beneficial effect on people with chronic liver diseases.

    Objectives: To assess the beneficial and harmful effects of vitamin D supplementation in people with chronic liver diseases. Read More

    Impact of vitamin D status on statin-induced myopathy.
    J Clin Transl Endocrinol 2016 Dec 23;6:56-59. Epub 2016 Nov 23.
    The University of Mississippi, School of Pharmacy, Jackson, MS, United States.
    Introduction: There is a multitude of evidence supporting the benefit of statin use in cardiovascular disease; however, statin-induced myopathy is a major reason for statin discontinuation and non-adherence. Vitamin D deficiency has been independently associated with muscle weakness and severe myopathy, and may be a confounder for statin-induced myopathies. Since there is no consensus on a treatment course of action for statin-induced myopathy, investigation into potential confounders to elucidate the dynamics of statin-induced myopathy is warranted. Read More

    [Status of daily life activities and respective risk factors among centenarian population in Hainan province].
    Zhonghua Liu Xing Bing Xue Za Zhi 2017 Oct;38(10):1342-1346
    Institute of Geriatrics, Beijing Key Laboratory of Research on Aging and Related Disease, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
    To investigate the Activity of Daily life (ADL) among individuals aged 100 and above, in Hainan.From June 2014 to December 2016, a community-based cross-sectional study was conducted among individuals aged 100 and over in Hainan province. Data regarding basic information, ADL, prevalence of major age-related diseases was collected in this population. Read More

    The Relationship between Vitamin D and Type 2 Diabetes Is Intriguing: Glimpses from the Spect-China Study.
    Ann Nutr Metab 2017 13;71(3-4):195-202. Epub 2017 Oct 13.
    Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
    Objective: Vitamin D is a multifunctional vitamin for our body. Type 2 diabetes mellitus (T2DM) is a common metabolic disease. Whether T2DM affects the serum 25(OH)D level has not been reported. Read More

    Clinical diagnostic tools for vitamin D assessment.
    J Steroid Biochem Mol Biol 2017 Oct 6. Epub 2017 Oct 6.
    Department of Chemistry, College of Science, UAE University, Al Ain, United Arab Emirates.
    Vitamin D deficiency has been implicated in a plethora of diseases including rheumatoid arthritis, Parkinson's disease, Alzheimer's disease, and osteoporosis. Deficiency of this vitamin is a global epidemic affecting both developing and developed nations. Within a clinical context, the qualitative and quantitative analysis of vitamin D is therefore vital. Read More

    Rev Paul Pediatr 2017 Apr-Jun;35(2):207-215. Epub 2017 May 29.
    Universidade Federal de Pernambuco (UFPE), Recife, PE, Brasil.
    Objective: To describe mechanisms by which glucocorticoids cause osteoporosis, with fracture risk, combining this learning with a possible professional behavior change.

    Data Sources: A systematic search on SciELO, PubMed, Scopus, and Medline databases was carried out for consensus, review articles, including systematic reviews and meta-analysis, which were published in English, between 2000 and 2016. Keywords used on the search were the following: glucocorticoids, fractures, osteoporosis, bone health, vitamin D, children, and adolescents. Read More

    Intermediate and low abundant protein analysis of vitamin D deficient obese and non-obese subjects by MALDI-profiling.
    Sci Rep 2017 Oct 3;7(1):12633. Epub 2017 Oct 3.
    Department of Biomedical Sciences for Health, University of Milan, Segrate (Milan), Italy.
    Obesity is a pathological condition caused by genetic and environmental factors, including vitamin D deficiency, which increases the risk of developing cardiovascular disorders and diabetes. This case-control study was designed to verify whether serum profiles could be identified differentiating obese and non-obese Saudis characterized by vitamin D deficiency and pathological levels of triglycerides, high-density lipoprotein cholesterol and high total cholesterol levels. The serum protein profiles of 64 vitamin D deficient (serum 25(OH)D < 50nmol/L) individuals with metabolic syndrome and with (n = 31; BMI ≥ 30) or without (n = 33; BMI < 30) obesity were analyzed by a quantitative label-free mass spectrometry approach (MALDI-profiling), combined with different serum immunodepletion strategies (Human7 and Human14 immuno-chromatographies), to analyze the intermediate- and low-abundant protein components. Read More

    A case of osteomalacia due to deranged mineral balance caused by saccharated ferric oxide and short-bowel syndrome: A case report.
    Medicine (Baltimore) 2017 Sep;96(39):e8147
    aDepartment of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University bDivision of Laboratory and Transfusion Medicine, Hokkaido University Hospital, Sapporo, Japan.
    Rationale: Saccharated ferric oxide has been shown to lead to elevation of fibroblast growth factor 23, hypophosphatemia, and, consequently, osteomalacia. Moreover, mineral imbalance is often observed in patients with short-bowel syndrome to some degree.

    Patient Concerns: A 62-year-old woman with short-bowel syndrome related with multiple resections of small intestines due to Crohn disease received regular intravenous administration of saccharated ferric oxide. Read More

    Vitamin D deficiency accelerates ageing and age-related diseases: a novel hypothesis.
    J Physiol 2017 Nov 31;595(22):6825-6836. Epub 2017 Oct 31.
    The Babraham Institute, Cambridge, CB22 3AT, UK.
    Ageing can occur at different rates, but what controls this variable rate is unknown. Here I have developed a hypothesis that vitamin D may act to control the rate of ageing. The basis of this hypothesis emerged from studyng the various cellular processes that control ageing. Read More

    Comparison of 25-hidroksi Vitamin D serum concentrations in patients with psoriasis and psoriatic arthritis.
    J Back Musculoskelet Rehabil 2018 Feb;31(1):37-43
    Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Sakarya University Medical Faculty, Sakarya, Turkey.
    Background And Objective: Rheumatoid arthritis (RA), insulin-dependent diabetes mellitus (IDDM), inflammatory bowel disease, systemic lupus erythematosus (SLE) and multiple sclerosis (MS) are some of the autoimmune diseases related to the decreases in Vitamin D levels. The same immunological properties as psoriasis, such as Th1/Th2 dysregulation, are seen in all of them. This study aims to compare 25-hidroksi Vitamin D (25-OHD) serum concentrations in patients with psoriasis and psoriatic arthritis. Read More

    Relationship of insulin resistance to vitamin d status in children with nondiabetic chronic kidney disease.
    Saudi J Kidney Dis Transpl 2017 Sep-Oct;28(5):1078-1084
    Department of Pediatric Nephrology, Ege University Medical Faculty, Izmir, Turkey.
    Insulin Resistance is common in patients with mild-to-moderate stage chronic kidney disease (CKD), even when the glomerular filtration rate is within the normal range. This study aimed to investigate the association of IR and 25-hydroxyvitamin D levels. In this study, we evaluated the frequency of IR in predialysis patients and the association with 25-hydroxyvitamin (OH)D levels. Read More

    Celiac disease-related osteopathy among Saudi celiac patients: Are we adherent to recommendations?
    Saudi J Gastroenterol 2017 Sep-Oct;23(5):291-295
    Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
    Background/aims: There are no reports from Saudi Arabia documenting the picture of osteopathy in celiac disease (CD) and the adherence of physicians to the guidelines and recommendations to screen for bone disease. We conducted this study to document the prevalence of CD-related osteopathy and the Saudi physicians' adherence to the screening recommendations.

    Patients And Methods: We identified the biopsy proven CD cases diagnosed between 2003 and 2012. Read More

    Vitamin D Is Associated with Severity and Mortality of Non-alcoholic Fatty Liver Disease: A US Population-based Study.
    J Clin Transl Hepatol 2017 Sep 7;5(3):185-192. Epub 2017 Jul 7.
    Division of Gastroenterology and Hepatology, Rutgers New Jersey Medical School, Newark, NJ, USA.
    There has been increasing evidence that vitamin D deficiency may increase the risk of metabolic syndrome. Since metabolic syndrome is a major risk factor for non-alcoholic fatty liver disease (NAFLD), we aimed to investigate the association between vitamin D and the severity and mortality of NAFLD.Data was obtained from the United States Third National Health and Nutrition Examination Survey conducted in 1988-1994, with follow-up mortality data through 2011. Read More

    Adult vitamin D deficiency exacerbates impairments caused by social stress in BALB/c and C57BL/6 mice.
    Psychoneuroendocrinology 2017 Dec 6;86:53-63. Epub 2017 Sep 6.
    Queensland Brain Institute, The University of Queensland, St Lucia, QLD, Australia; Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Richlands, QLD, Australia. Electronic address:
    Vitamin D deficiency is prevalent in adults throughout the world. Epidemiological studies have shown significant associations between vitamin D deficiency and an increased risk of various neuropsychiatric and neurodegenerative disorders, such as schizophrenia, depression, Alzheimer's disease and cognitive impairment. However, studies based on observational epidemiology cannot address questions of causality; they cannot determine if vitamin D deficiency is a causal factor leading to the adverse health outcome. Read More

    Vitamin D Nutritional Status and its Related Factors for Chinese Children and Adolescents in 2010-2012.
    Nutrients 2017 Sep 15;9(9). Epub 2017 Sep 15.
    Key Laboratory of Trace Element Nutrition of National Health and Family Planning Commission, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
    Vitamin D plays a critical role in calcium and phosphate metabolism and helps maintain skeletal integrity in childhood, yet vitamin D status in Chinese children and adolescents is not well documented. The aim of this study was to assess the vitamin D status and analyze the risk factors for vitamin D deficiency in Chinese children and adolescents aged 6-17 years. Serum 25 hydroxyvitamin D (25(OH)D) was measured with a radioimmunoassay kit in 15,000 children and adolescent participants in the Chinese national nutrition and health survey (CNNHS) 2010-2012. Read More

    Digestive system in psoriasis: an update.
    Arch Dermatol Res 2017 Nov 13;309(9):679-693. Epub 2017 Sep 13.
    Dermatologikum Hamburg, Hamburg, Germany.
    Psoriasis is a chronic inflammatory immune-mediated disorder associated and often coexisting with many other immune-related clinical conditions including those affecting the gastrointestinal tract. Data obtained from the reviewed literature suggest an association between psoriasis and pathologies of the oral cavity, both psoriasis-specific lesions, as well as non-specific, such as geographic tongue or fissured tongue. These findings show the importance of thorough examination of oral mucosa in psoriatic patients. Read More

    Disorders of Mechanisms of Calcium Metabolism Control as Potential Risk Factors of Prostate Cancer.
    Curr Med Chem 2017 ;24(38):4229-4244
    Department of Bromatology, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.
    Prostate cancer significantly affects the overall morbidity and mortality of malignant tumours in highly developed countries. Important risk factors include family predisposition and regional, racial and dietary determinants. The scientific literature contains a great deal of data on the role of calcium and dairy products in general in the process of neoplastic transformation of the prostate. Read More

    Bone mineral density and vitamin D status in systemic lupus erythematosus (SLE): A systematic review.
    Autoimmun Rev 2017 Nov 9;16(11):1155-1159. Epub 2017 Sep 9.
    Hospital del Mar/Parc de Salut-Mar/IMIM, Barcelona, Spain. Electronic address:
    Despite the improvement in the quality of life of patients with SLE due to scientific and technological advances, SLE remains a disease that over the years may produce irreversible damage to patients. Osteoporosis and secondary bone fractures are two of the major causes of irreparable injury in patients with SLE. Vitamin D insufficiency may play a vital role both in reduced bone mineral density (BMD) and in the appearance of fractures, although its mechanisms of action are still unclear. Read More

    The relationship between 25-hydroxyvitamin D concentration and liver enzymes in overweight or obese adults: Cross-sectional and interventional outcomes.
    J Steroid Biochem Mol Biol 2018 Mar 9;177:193-199. Epub 2017 Sep 9.
    Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3168, Australia; Diabetes and Vascular Medicine Unit, Monash Health, Melbourne, VIC 3168, Australia. Electronic address:
    Vitamin D deficiency is prevalent in individuals with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis. However, there is limited and inconsistent data on the effect of vitamin D supplementation on liver function. Hepatic enzymes have been used as surrogate markers for NAFLD and have been associated with metabolic syndrome. Read More

    Independent and Synergistic Associations of Biomarkers of Vitamin D Status With Risk of Coronary Heart Disease.
    Arterioscler Thromb Vasc Biol 2017 Nov 7;37(11):2204-2212. Epub 2017 Sep 7.
    From the Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA (L.Q., Y.H., T.W., D.S.); Department of Epidemiology (L.Q., W.M., E.B.R., F.B.H., E.G., J.E.M.) and Department of Nutrition (L.Q., Y.Z., E.B.R., F.B.H., E.G.), Harvard T.H. Chan School of Public Health, Boston, MA; and Channing Division of Network Medicine (L.Q., E.B.R., F.B.H., E.G., J.E.M.) and Division of Preventive Medicine (C.M.A., K.M.R., J.E.M.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
    Objective: To comprehensively evaluate the independent associations and potential interactions of vitamin D-related biomarkers including total and bioavailable 25-hydroxyvitamin D (25OHD), VDBP (vitamin D binding protein), and parathyroid hormone (PTH) with risk of coronary heart disease (CHD).

    Approach And Results: We prospectively identified incident cases of nonfatal myocardial infarction and fatal CHD among women in the Nurses' Health Study during 20 years of follow-up (1990-2010). Using risk-set sampling, 1 to 2 matched controls were selected for each case. Read More

    Vitamin D prenatal programming of childhood metabolomics profiles at age 3 y.
    Am J Clin Nutr 2017 Oct 23;106(4):1092-1099. Epub 2017 Aug 23.
    Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; and
    Vitamin D deficiency is implicated in a range of common complex diseases that may be prevented by gestational vitamin D repletion. Understanding the metabolic mechanisms related to in utero vitamin D exposure may therefore shed light on complex disease susceptibility.The goal was to analyze the programming role of in utero vitamin D exposure on children's metabolomics profiles. Read More

    Role of vitamin D in cystic fibrosis and non-cystic fibrosis bronchiectasis.
    World J Clin Pediatr 2017 Aug 8;6(3):132-142. Epub 2017 Aug 8.
    Maria Moustaki, Ioanna Loukou, Cystic Fibrosis Unit, "Aghia Sophia" Children's Hospital, 11527 Athens, Greece.
    Bronchiectasis is usually classified as cystic fibrosis (CF) related or CF unrelated (non-CF); the latter is not considered an orphan disease any more, even in developed countries. Irrespective of the underlying etiology, bronchiectasis is the result of interaction between host, pathogens, and environment. Vitamin D is known to be involved in a wide spectrum of significant immunomodulatory effects such as down-regulation of pro-inflammatory cytokines and chemokines. Read More

    Osteoporosis in patients with erythropoietic protoporphyria.
    Br J Dermatol 2017 Dec 22;177(6):1693-1698. Epub 2017 Nov 22.
    Department of Internal Medicine, Porphyria Centre, Centre for Lysosomal and Metabolic Diseases, Erasmus MC, PO Box 2040, 3000, CA Rotterdam, the Netherlands.
    Background: Erythropoietic protoporphyria (EPP) is a rare metabolic disease with painful photosensitivity due to protoporphyrin IX accumulation.

    Objectives: To evaluate bone mineral density (BMD) and known osteoporosis risk factors in patients with EPP.

    Methods: Patients with EPP attending the Erasmus MC outpatient clinic who had undergone BMD measurements were included. Read More

    Vitamin D deficiency is a risk factor for infections in patients affected by HCV-related liver cirrhosis.
    Int J Infect Dis 2017 Oct 10;63:23-29. Epub 2017 Aug 10.
    Department of Clinical Medicine and Surgery, Section of Infectious Diseases, University of Naples "Federico II", Italy.
    Objectives: To evaluate the prevalence of vitamin D deficiency and its impact on infections in HCV-related liver cirrhosis.

    Methods: We enrolled 291 patients affected by HCV-related liver cirrhosis. Serum vitamin D levels were dosed at enrolment. Read More

    Vitamin D and symptoms of depression in overweight or obese adults: A cross-sectional study and randomized placebo-controlled trial.
    J Steroid Biochem Mol Biol 2018 Mar 10;177:200-208. Epub 2017 Aug 10.
    Monash Centre for Health Research and Implementation (MCHRI), School of Public Health and Preventive Medicine, Monash University, 43-51 Kanooka Grove, Clayton, Melbourne, VIC 3168, Australia. Electronic address:
    Recent evidence suggests that vitamin D deficiency may contribute to increased risk of depression. However, previous studies are limited by variability in participant characteristics including vitamin D deficiency status and presence of existing diseases, use of low doses of vitamin D supplementation for short durations, and use of co-interventions or psychotropic drugs. We examined whether 25-hydroxyvitamin D (25(OH)D) concentrations were associated with symptoms of depression, as well as whether vitamin D supplementation reduced symptoms of depression in overweight or obese and vitamin D-deficient, but otherwise healthy adults. Read More

    Vitamin D in the Spectrum of Prediabetes and Cardiovascular Autonomic Dysfunction.
    J Nutr 2017 09 2;147(9):1607-1615. Epub 2017 Aug 2.
    Department of Diabetology, Clinical Center of Endocrinology, Medical University, Sofia, Sofia, Bulgaria.
    Vitamin D is a fat-soluble secosteroid hormone with pleiotropic effects. 1,25-Dihydroxyvitamin D coordinates the biosynthesis of neurotransmitters in the central nervous system, which regulate cardiovascular autonomic function and may explain its putative role in the development of cardiovascular autonomic neuropathy (CAN). CAN is an independent risk factor for mortality in patients with diabetes and prediabetes and is associated with an increased risk of developing type 2 diabetes and cardiovascular disease. Read More

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