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    1195 results match your criteria Vitamin D Deficiency and Related Disorders

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    An efficient synthesis of 1α,25-dihydroxyvitamin D3 LC-biotin.
    J Steroid Biochem Mol Biol 2017 Feb 6. Epub 2017 Feb 6.
    Endotherm Life Science Molecules, 66123 Saarbrücken, Germany. Electronic address:
    In recent years the apparent impact of vitamin D deficiency on human health has gained increased awareness. Consequently, the development of appropriate assays to measure the status of medicinally most relevant vitamin D metabolites in human blood, serum or relevant tissue is continuously being improved. Particularly, assaying of 1α,25-dihydroxyvitamin D3, in turn considered as the most active metabolite, is mainly indicated in disorders leading to calcaemia or those resulting from an impaired 1α-hydroxylation of 25-hydroxyvitamin D3. Read More

    Thyroid disorders in polycystic ovary syndrome.
    Eur Rev Med Pharmacol Sci 2017 Jan;21(2):346-360
    Department of Gynaecological Endocrinology, Medical Faculty in Katowice, Medical University of Silesia, Katowice, Poland.
    Objective: Thyroid disorders, especially Hashimoto's thyroiditis (HT), are observed significantly more often in patients with polycystic ovary syndrome (PCOS) than in the general population - approximately 27% and 8%, respectively. This is extremely important in young women, because both disorders are connected with fertility problems. As HT and PCOS occur together, fertility problems may become a serious clinical issue in these patients. Read More

    Effects of Vitamin D treatment on thyroid autoimmunity.
    J Res Med Sci 2016 18;21:85. Epub 2016 Oct 18.
    Department of Endocrinology and Metabolism, Kayseri Training and Research Hospital, Kayseri, Turkey.
    Background: Vitamin D was shown to be related to autoimmune thyroid diseases (AITDs) in the previous studies. We aimed to investigate the relationship between Vitamin D and thyroid autoimmunity.

    Materials And Methods: Eighty-two patients, diagnosed with AITD by the endocrinology outpatient clinic, were included in this prospective study. Read More

    Are Systematic Screening for Vitamin D Deficiency and Vitamin D Supplementation Currently Feasible for Ankylosing Spondylitis Patients?
    Int J Inflam 2017 1;2017:7840150. Epub 2017 Jan 1.
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa.
    Beyond its role in calcium and phosphorus metabolism for healthy bone mineralization, there is increasing awareness for vitamin D contribution in modulation of immune reactions. Given that ankylosing spondylitis (AS) is a chronic inflammatory disease involving excess immune/inflammatory activity and posing great therapeutic challenges, it is conceivable to claim that vitamin D treatment may be a safe and effective treatment to influence or modify the primary disease and its related comorbidities. Nevertheless, consistent body of research supporting this hypothesis is still lacking. Read More

    Vitamin D supplementation for sickle cell disease.
    Cochrane Database Syst Rev 2017 Jan 20;1:CD010858. Epub 2017 Jan 20.
    Comprehensive Sickle Cell Program, Aflac Cancer and Blood Disorders Service, Emory University School of Medicine, 1405 Clifton Road, NE, Atlanta, Georgia, USA, GA 30322.
    Background: Sickle cell disease is a genetic chronic haemolytic and pro-inflammatory disorder. The clinical manifestations of sickle cell disease result from the presence of mutations on the beta globin genes that generate an abnormal haemoglobin product (called haemoglobin S) within the red blood cell. Sickle cell disease can lead to many complications such as acute chest syndrome, stroke, acute and chronic bone complications (including painful vaso-occlusive crisis, osteomyelitis, osteonecrosis and osteoporosis). Read More

    The prevalence trend of metabolic syndrome and its components and risk factors in Korean adults: results from the Korean National Health and Nutrition Examination Survey 2008-2013.
    BMC Public Health 2017 Jan 13;17(1):71. Epub 2017 Jan 13.
    Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 410-769, Republic of Korea.
    Background: Abnormalities in the clinical markers of metabolic syndrome (MS) are associated with the development of cardiovascular disease, type 2 diabetes mellitus, and some cancers. MS prevalence in Korea increased between the mid-1990s and mid-2000s; however, no data on the recent trends of MS prevalence are available. Thus, we aimed to investigate the prevalence of MS, the five components of MS, and the related risk factors in Korean adults by using recent data. Read More

    [Nutritional status and influence of vitamin D among Chinese lactating women in 2013].
    Zhonghua Yu Fang Yi Xue Za Zhi 2016 Dec;50(12):1056-1060
    National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention; Key Laboratory of Trace Element Nutrition, National Health and Family Planning Commission, Beijing 100050, China.
    Objective: To analyze serum vitamin D levels in Chinese lactating women, in 2013, and to evaluate their vitamin D nutritional status and influencing factors. Methods: Data were from the Chinese National Nutrition and Health Surveillance in 2013. Using the multistage stratified cluster sampling method, serum samples from lactating women, at 0-24 months postpartum, were obtained from 55 sites in 30 provinces of China, excluding the Tibet Autonomous Region. Read More

    Vitamin D in autoimmune rheumatic diseases: A view inside gender differences.
    Pharmacol Res 2017 Mar 31;117:228-241. Epub 2016 Dec 31.
    Department of Movement, Human and Health Sciences, University of Rome Foro Italico, 00135 Rome, Italy. Electronic address:
    A large body of evidence highlights the role for vitamin D deficiency/insufficiency in rheumatic diseases, a group of different pathologies mostly of autoimmune origin. Vitamin D and vitamin D receptor agonists exquisitely modulate the immune system against over-reactivity towards tolerance; on this basis, vitamin D could be a good therapeutic candidate to control autoimmune processes in rheumatic diseases. Similarly, to other autoimmune pathologies, rheumatic diseases show a significant female bias. Read More

    Cognitive changes under memantine according to vitamin D status in Alzheimer patients: An exposed/unexposed cohort pilot study.
    J Steroid Biochem Mol Biol 2016 Dec 29. Epub 2016 Dec 29.
    Department of Neuroscience and Aging, Division of Geriatric Medicine, Angers University Hospital, University Memory Clinic, Research Center on Autonomy and Longevity, UPRES EA 4638, University of Angers, UNAM, Angers, France; Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada. Electronic address:
    Memantine is a symptomatic treatment that partially prevents cognitive decline in Alzheimer disease (AD). The neuroprotective effects of memantine and vitamin D may potentiate each other, with benefits for cognition. The objective of this exposed/unexposed pilot study was to determine the cognitive changes among AD patients using memantine according to the presence or absence of vitamin D deficiency (VDD). Read More

    Vitamin D in Saudi Arabia: Prevalence,distribution and disease associations.
    J Steroid Biochem Mol Biol 2016 Dec 24. Epub 2016 Dec 24.
    Biomarkers Research Program,Biochemistry Department,College of Science,King Saud University,Riyadh 11451,Saudi Arabia; Prince Mutaib Chair for Biomarkers of Osteoporosis,Biochemistry Department,College of Science,King Saud University,Riyadh 11451,Saudi Arabia. Electronic address:
    More than 33 years have passed since the first paper highlighting vitamin D deficiency as a public health concern in Saudi Arabia was published in 1983. Despite "early" detection,it wasn't until the year 2010 where the interest in vitamin D research grew exponentially worldwide and was finally visible in Saudi clinical and academic areas. Since then,many landmark studies have been generated with regards to the physiologic functions of vitamin D,both skeletal and extra-skeletal. Read More

    Vitamin D and cardiovascular diseases: Causality.
    J Steroid Biochem Mol Biol 2016 Dec 24. Epub 2016 Dec 24.
    Professor of Medicine, Endocrinology & Nutrition, Cardio Metabolic Institute, NJ, USA. Electronic address:
    Vitamin D regulates blood pressure, cardiac functions, and endothelial and smooth muscle cell functions, thus, playing an important role in cardiovascular health. Observational studies report associations between vitamin D deficiency with hypertension and cardiovascular-related deaths. Peer-reviewed papers were examined in several research databases as per the guidelines of the Preferred Reporting Items for Systematic Reviews, using key words that address the relationship between vitamin D and cardiovascular disease. Read More

    The Association of Vitamin D Deficiency and Incident Frailty in Older Women: The Role of Cardiometabolic Diseases.
    J Am Geriatr Soc 2016 Dec 23. Epub 2016 Dec 23.
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland.
    Objectives: Evidence suggests vitamin D deficiency is associated with developing frailty. However, cardiometabolic factors are related to both conditions and may confound and/or mediate the vitamin D-frailty association. We aimed to determine the association of vitamin D concentration with incidence of frailty, and the role of cardiometabolic diseases (cardiovascular disease, diabetes, hyperlipidemia, hypertension) in this relationship. Read More

    Seasonality of tuberculosis in Israel, 2001-2011.
    Int J Tuberc Lung Dis 2016 Dec;20(12):1588-1593
    Ramla Department of Health, Ministry of Health, Ramla, School of Public Health, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Background: Several studies have suggested that the incidence of tuberculosis (TB) varies with the seasons.

    Objective: To determine the seasonality of TB in Israel and to explore possible associations with climatic variables.

    Methods: Laboratory-confirmed TB cases reported between 2001 and 2011 in individuals resident in Israel for at least 1 year before diagnosis were included in the study. Read More

    Effects of Vitamin D on Endometriosis-Related Pain: A Double-Blind Clinical Trial.
    Med Sci Monit 2016 Dec 17;22:4960-4966. Epub 2016 Dec 17.
    Department of Endoscopic Surgery, Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran.
    BACKGROUND Endometriosis is a disabling disease of reproductive-age women. Dysmenorrhea, dyspareunia, and pelvic pain are the main symptoms of endometriosis. Its etiology is not clear. Read More

    Vitamin D supplementation, the metabolic syndrome and oxidative stress in obese children.
    J Pediatr Endocrinol Metab 2016 Dec 15. Epub 2016 Dec 15.
    Background: Previous studies suggest that vitamin D may play a role in cardiovascular and metabolic health. Oxidative stress has also been implicated in the development of cardiovascular disease. Evidence suggests that vitamin D deficiency may contribute to the occurrence of oxidative stress. Read More

    Brown tumor of the jaw after pregnancy and lactation in a MEN1 patient.
    Endocrinol Diabetes Metab Case Rep 2016 16;2016. Epub 2016 Nov 16.
    Department of Endocrinology.
    : Skeletal manifestations of primary hyperparathyroidism (pHPT) include brown tumors (BT), which are osteoclastic focal lesions often localized in the jaws. Brown tumors are a rare manifestation of pHTP in Europe and USA; however, they are frequent in developing countries, probably related to vitamin D deficiency and longer duration and severity of disease. In the majority of cases, the removal of the parathyroid adenoma is enough for the bone to remineralize, but other cases require surgery. Read More

    Seasonality of tuberculosis in Israel, 20012011.
    Int J Tuberc Lung Dis 2016 Dec;20(12):1588-1593
    Ramla Department of Health, Ministry of Health, Ramla, School of Public Health, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Background: Several studies have suggested that the incidence of tuberculosis (TB) varies with the seasons.

    Objective: To determine the seasonality of TB in Israel and to explore possible associations with climatic variables.

    Methods: Laboratory-confirmed TB cases reported between 2001 and 2011 in individuals resident in Israel for at least 1 year before diagnosis were included in the study. Read More

    Vitamin D deficiency: What does it mean for chronic obstructive pulmonary disease (COPD)? a compherensive review for pulmonologists.
    Clin Respir J 2016 Dec 7. Epub 2016 Dec 7.
    Department of Pulmonology, School of Medicine, Clinical Science Center, St George University, London, UK.
    Objectives: Vitamin D deficiency and Chronic Obstructive Pulmonary Disease (COPD) are both under-recognized health problems, world-wide. Although Vitamin D has long been known for calcemic effects it also has less known noncalcemic effects. Recent data have shown that Vitamin D deficiency is highly prevalent in patients with COPD and correlates with forced expiratory volume in one second (FEV1 ) and FEV1 decline. Read More

    Is Vitamin D an Independent Risk Factor of Nonalcoholic Fatty Liver Disease?: a Cross-Sectional Study of the Healthy Population.
    J Korean Med Sci 2017 Jan;32(1):95-101
    Department of Family Medicine, Seoul National University Hospital, Seoul, Korea.
    The association between vitamin D levels and nonalcoholic fatty liver disease (NAFLD) has been recognized. However, few studies showed independent associations between vitamin D deficiency and NAFLD after a sex-related adjustment for metabolic factors. We aimed to study whether vitamin D deficiency is an independent risk factor of NAFLD even after controlling for metabolic syndrome and visceral fat in both sexes. Read More

    Gestational vitamin D deficiency and autism-related traits: the Generation R Study.
    Mol Psychiatry 2016 Nov 29. Epub 2016 Nov 29.
    Queensland Brain Institute, The University of Queensland, St Lucia, QLD, Australia.
    There is intense interest in identifying modifiable risk factors associated with autism-spectrum disorders (ASD). Autism-related traits, which can be assessed in a continuous fashion, share risk factors with ASD, and thus can serve as informative phenotypes in population-based cohort studies. Based on the growing body of research linking gestational vitamin D deficiency with altered brain development, this common exposure is a candidate modifiable risk factor for ASD and autism-related traits. Read More

    [Vitamin D deficiency and morbimortality in critically ill paediatric patients].
    An Pediatr (Barc) 2016 Nov 25. Epub 2016 Nov 25.
    Unidad de Cuidados Intensivos Pediátricos, Hospital Regional Universitario de Málaga, Málaga, España.
    Objectives: To determine the prevalence and risks factors of vitamin D deficiency, as well as its relationship with morbidity and mortality in a PICU.

    Material And Methods: An observational prospective study in a tertiary children's University Hospital PICU conducted in two phases: i: cohorts study, and ii: prevalence study. The study included 340 critically ill children with ages comprising 6 months to 16 years old. Read More

    The Correlation Between Serum Vitamin D Deficiency and Preterm Birth.
    Med Sci Monit 2016 Nov 16;22:4401-4405. Epub 2016 Nov 16.
    Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China (mainland).
    BACKGROUND Preterm birth is an important cause of death and developmental disorder in neonates. Vitamin D deficiency has been shown to regulate body inflammatory factor levels that stimulate elevation of uterine contraction hormones, such as prostaglandin, thus causing preterm birth. However, current observations regarding the relationship between vitamin D and preterm birth are inconsistent. Read More

    Older Swedish Adults with High Self-Perceived Health Show Optimal 25-Hydroxyvitamin D Levels Whereas Vitamin D Status Is Low in Patients with High Disease Burden.
    Nutrients 2016 Nov 11;8(11). Epub 2016 Nov 11.
    Department of Medicine and Optometry, Linnaeus University, 392 34 Kalmar, Sweden.
    Controversy pervades the definition of adequate and optimal vitamin D status. The Institutes of Medicine have recommended serum 25(OH)D levels above 50 nmol/L based upon evidence related to bone health, but some experts, including the Endocrine Society and International Osteoporosis Foundation, suggest a minimum serum 25(OH)D level of 75 nmol/L to reduce the risk of falls and fractures in older adults. In a cross-sectional study, we compared vitamin D status in people ≥75 years selected from four groups with a frailty phenotype, combined with a control group free from serious illness, and who considered themselves completely healthy. Read More

    Vitamin D3 Loading Is Superior to Conventional Supplementation After Weight Loss Surgery in Vitamin D-Deficient Morbidly Obese Patients: a Double-Blind Randomized Placebo-Controlled Trial.
    Obes Surg 2016 Nov 12. Epub 2016 Nov 12.
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
    Background: Bariatric patients often suffer from vitamin D deficiency (VDD), and both, morbid obesity and VDD, are related to non-alcoholic fatty liver disease. However, limited data are available regarding best strategies for treating VDD, particularly, in bariatric patients undergoing omega-loop gastric bypass (OLGB). Therefore, we examined the efficacy and safety of a forced vitamin D dosing regimen and intervention effects in liver fibrotic patients. Read More

    Vitamin D (25(OH)D) in patients with chronic kidney disease stages 2-5.
    Colomb Med (Cali) 2016 Sep 30;47(3):160-166. Epub 2016 Sep 30.
    Universidad de Manizales, Manizales, Colombia.
    Objective: To establish the impact the chronic kidney disease stage has in the native vitamin D levels in patients not undergoing dialysis treatment.

    Methods: A study performed in Manizales, Colombia, a city located 2,200 meters above sea level, without important stational variations. Patients with 18 years of age or more, with chronic kidney disease stages 2 to 5 and not undergoing dialysis treatment were recruited for this study. Read More

    Decreased preoperative serum 25-Hydroxyvitamin D levels in colorectal cancer are associated with systemic inflammation and serrated morphology.
    Sci Rep 2016 Nov 7;6:36519. Epub 2016 Nov 7.
    Cancer and Translational Medicine Research Unit, University of Oulu, POB 5000, 90014 Oulu, Finland.
    Deficiency of vitamin D is associated with increased risk of several types of cancer including colorectal cancer (CRC). However, factors contributing to low levels of 25-hydroxyvitamin D [25(OH)D] in CRC are not clear. Therefore, in this study serum 25(OH)D levels in 117 CRC patients and 86 controls were analyzed and correlated with the clinicopathological data including morphological subtype (serrated or conventional), quantity of tumor infiltrating immune cells, levels of systemic inflammatory markers, and disease outcome. Read More

    The protective role of vitamin D on the heart and the kidney.
    Ther Adv Cardiovasc Dis 2016 Oct 26. Epub 2016 Oct 26.
    Fundación J. Robert Cade, Pedro de Oñate 253-Córdoba 5003, Argentina
    For a long time, vitamin D was regarded as an essential component for the maintenance of appropriate calcium metabolism. Indeed, the calcium-related functions were broadly studied and validated in numerous clinical and epidemiologic studies. All of these vitamin D effects are mediated by a specific receptor. Read More

    Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1.
    Cell Rep 2016 Oct;17(5):1227-1237
    The Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA. Electronic address:
    Vitamin D has multiple roles, including the regulation of bone and calcium homeostasis. Deficiency of 25-hydroxyvitamin D, the major circulating form of vitamin D, is associated with an increased risk of age-related chronic diseases, including Alzheimer's disease, Parkinson's disease, cognitive impairment, and cancer. In this study, we utilized Caenorhabditis elegans to examine the mechanism by which vitamin D influences aging. Read More

    Metabolically Obese Individuals of Normal Weight Have a High Risk of 25-Hydroxyvitamin D Deficiency.
    Am J Med Sci 2016 Oct 1;352(4):360-367. Epub 2016 Jul 1.
    Department of Endocrinology and Metabolism, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, Xinjiang, China. Electronic address:
    Background: Vitamin D status is related to obesity-related metabolic disorders. We investigated the risk of 25-hydroxyvitamin D [25(OH)D] deficiency among different metabolic phenotypes.

    Methods: This prospective cross-sectional study evaluated 1,292 individuals who were ≥40 years old. Read More

    Vitamin D Storage in Adipose Tissue of Obese and Normal Weight Women.
    J Bone Miner Res 2017 Feb 24;32(2):237-242. Epub 2016 Oct 24.
    Division of Endocrinology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA.
    Although vitamin D deficiency is prevalent among obese individuals, its cause is poorly understood. Few studies have measured vitamin D concentrations in adipose of obese (OB) subjects, and none have included normal weight controls (C). The goal of this study was to investigate whether the relationship between body composition, serum 25-hydroxyvitamin D (25OHD), vitamin D in subcutaneous (SQ) and omental (OM) adipose, and total adipose stores of vitamin D differ among OB and C. Read More

    Vitamin D Deficiency in Adult Patients with Schizophreniform and Autism Spectrum Syndromes: A One-Year Cohort Study at a German Tertiary Care Hospital.
    Front Psychiatry 2016 6;7:168. Epub 2016 Oct 6.
    Section of Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg , Freiburg , Germany.
    Introduction: Vitamin D has many immunomodulatory, anti-inflammatory, and neuroprotective functions, and previous studies have demonstrated an association between vitamin D deficiency and neuropsychiatric disease. The aim of our study was to analyze the prevalence of vitamin D deficiency in a 1-year cohort of adult inpatients with schizophreniform and autism spectrum syndromes in a naturalistic inpatient setting in Germany.

    Participants And Methods: Our study was comprised of 60 adult schizophreniform and 23 adult high-functioning autism spectrum patients who were hospitalized between January and December of 2015. Read More

    Insulin resistance in chronic kidney disease: a systematic review.
    Am J Physiol Renal Physiol 2016 Dec 5;311(6):F1087-F1108. Epub 2016 Oct 5.
    Consiglio Nazionale delle Ricerche-Istituto di Fisiologia Clinica, Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension, Reggio di Calabria, Italy.
    Insulin resistance (IR) is an early metabolic alteration in chronic kidney disease (CKD) patients, being apparent when the glomerular filtration rate is still within the normal range and becoming almost universal in those who reach the end stage of kidney failure. The skeletal muscle represents the primary site of IR in CKD, and alterations at sites beyond the insulin receptor are recognized as the main defect underlying IR in this condition. Estimates of IR based on fasting insulin concentration are easier and faster but may not be adequate in patients with CKD because renal insufficiency reduces insulin catabolism. Read More

    Bone Histology of Two Cases with Osteomalacia Related to Low-dose Adefovir.
    Intern Med 2016;55(20):3013-3019. Epub 2016 Oct 15.
    Nephrology Center, Toranomon Hospital, Japan.
    We performed a bone histomorphometric analysis in two patients demonstrating Fanconi syndrome with hypophosphatemia, adefovir-related bone disease and chronic hepatitis B infection. Both patients had osteomalacia, but showed two different histological patterns. The osteoid volume of the patient without risedronate increased with [(osteoid volume/ bone volume)×100=18. Read More

    Changes in circulating vitamin D levels with loss of adipose tissue.
    Curr Opin Clin Nutr Metab Care 2016 Nov;19(6):464-470
    aQuébec Heart and Lung Institute Research Centre bLipid Clinic, CHU de Québec-Université Laval cEndocrinology and Nephrology Unit, CHU de Québec Research Centre dFaculty of Medicine, Department of Kinesiology, Université Laval, Québec City, Québec, Canada.
    Purpose Of Review: Low vitamin D levels have been extensively reported in obesity. Thus, the pandemic of obesity has been paralleled by a high prevalence of low vitamin D status. Given the well documented associations linking poor vitamin D status to adverse health outcomes (diabetes, cardiovascular disease, cancers, all-cause mortality), a proper understanding of the mechanisms linking excess adiposity to low vitamin D status is key to identify and implement effective interventions to replenish vitamin D levels in obese individuals. Read More

    Environmental risk factors for dementia: a systematic review.
    BMC Geriatr 2016 Oct 12;16(1):175. Epub 2016 Oct 12.
    Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.
    Background: Dementia risk reduction is a major and growing public health priority. While certain modifiable risk factors for dementia have been identified, there remains a substantial proportion of unexplained risk. There is evidence that environmental risk factors may explain some of this risk. Read More

    Vitamin D modulates different IL-17-secreting T cell subsets in multiple sclerosis patients.
    J Neuroimmunol 2016 Oct 6;299:8-18. Epub 2016 Aug 6.
    Post-graduate Program in Neurology, Federal University of the State of Rio de Janeiro, Brazil; Department of Microbiology and Parasitology, Federal University of the State of Rio de Janeiro, Brazil. Electronic address:
    Vitamin D deficiency is an environmental risk factor for MS, a Th17 cell-mediated autoimmune disease that results in demyelination in the CNS. Therefore, we aimed to evaluate the ability of in vitro 1,25(OH)2D in modulating different Th17 cell subsets in MS patients in remission phase. In the present study, the production of Th17-related cytokines (IL-1β, IL-6, IL-17, IL-22), as well as GM-CSF, was significantly higher in cell cultures from MS patients than in healthy subjects (HS). Read More

    The other side of vitamin D therapy: 
a case series of acute kidney injury due to malpractice-related vitamin D intoxication
    Clin Nephrol 2016 Nov;86 (2016)(11):236-241
    Background: Vitamin D deficiency is highly prevalent in Indian Kashmir. Many people get injectable vitamin D (600,000 IU/injection). At times, the dose prescribed is far above the permissible limit. Read More

    Vitamin D Deficiency in Egyptian Systemic Lupus Erythematosus Patients: How Prevalent and Does It Impact Disease Activity?
    Integr Med Insights 2016 26;11:27-33. Epub 2016 Sep 26.
    Clinical Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
    Background: The emerging role of vitamin D in immunology and autoimmune disorders has been a worldwide interest in the last decade. Systemic lupus erythematosus (SLE) patients are particularly at a delicate position predisposing them to suffer from vitamin D deficiency due to the multiple risk factors accompanying the disease. Whether vitamin D deficiency is also involved as a risk factor for developing SLE and affecting its course is a considerable concern. Read More

    Body adiposity predictors of vitamin D status in nondialyzed patients with chronic kidney disease: A cross-sectional analysis in a tropical climate city.
    Nutrition 2017 Jan 26;33:240-247. Epub 2016 Jul 26.
    Nephrology Division, Rio de Janeiro State University, Rio de Janeiro, Brazil.
    Objectives: The association of vitamin D status with high body adiposity is poorly investigated in the chronic kidney disease (CKD) population. The aim of the present study was to describe vitamin D status and to identify body adiposity predictors of vitamin D deficiency, in a nondialyzed CKD population inhabiting a tropical city.

    Methods: This cross-sectional study included patients with CKD, defined as estimated glomerular filtration rate (eGFR) <60 mL/min, regularly treated by an interdisciplinary team in an outpatient university clinic, set in a Brazilian city (latitude: 22°54'S; 43°12'W). Read More

    Association of vitamin D deficiency with hepatitis B virus - related liver diseases.
    BMC Infect Dis 2016 Sep 23;16(1):507. Epub 2016 Sep 23.
    Vietnamese-German Center for Medical Research (VG-CARE), Hanoi, Vietnam.
    Background: As an immune modulator, vitamin D is involved in various pathophysiological mechanisms in a plethora of diseases. This study aims to correlate the vitamin D deficiency status and clinical progression of liver diseases associated with hepatitis B virus (HBV) infection in patients in Vietnam and to compare it to healthy controls.

    Methods: We quantified the levels of total vitamin D [25-(OH) D2 and D3] in serum samples from 400 HBV patients (chronic hepatitis B infection [CHB], n = 165; HBV-associated liver cirrhosis [LC], n = 127; HBV-associated hepatocellular carcinoma [HCC], n = 108) and 122 unrelated healthy controls (HC). Read More

    Cholecalciferol treatment downregulates renin-angiotensin system and improves endothelial function in essential hypertensive patients with hypovitaminosid D.
    J Hypertens 2016 Nov;34(11):2199-205
    aDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy *Davide Carrara and Rosa Maria Bruno contributed equally to the study.
    Background: Vitamin D deficiency is related to an increased prevalence of cardiovascular disease. Renin-angiotensin-aldosterone system suppression and vascular dysfunction are considered among the main mechanisms implicated in this association. However, interventional studies demonstrating that vitamin D replacement reduces circulating renin-angiotensin-aldosterone components and improves vascular function in humans are still lacking. Read More

    Osteoporosis Associated with Chronic Obstructive Pulmonary Disease.
    J Bone Metab 2016 Aug 31;23(3):111-20. Epub 2016 Aug 31.
    Third Department of Medicine, Teikyo University Chiba Medical Center, Japan.
    Recent epidemiological studies have revealed that osteoporosis is closely associated with common chronic diseases including diabetes, hypertension, chronic kidney disorders, and chronic obstructive pulmonary disease (COPD). COPD is a chronic inflammatory airway disease but now well known to be associated with various systemic comorbidities including osteoporosis. Osteoporosis and osteoporotic fractures are extremely common in COPD patients, which have significant impacts on their quality of life (QOL), activities of daily life (ADL), respiratory function, and possibly their prognosis. Read More

    Vitamin D Deficiency and Glycemic Status in Children and Adolescents with Type 1 Diabetes Mellitus.
    PLoS One 2016 8;11(9):e0162554. Epub 2016 Sep 8.
    Division of Pediatrics, Department of Health Sciences, University of Piemonte Orientale, Novara, Italy.
    Background: Vitamin D (25OHD) effects on glycemic control are unclear in children and adolescents with type 1 diabetes. Aims of this study were to investigate 25OHD status among children with T1DM and its relationship with insulin sensitivity and glycemic status.

    Subjects And Methods: A cross sectional study was carried out between 2008-2014. Read More

    Epidemiology of Fracture Nonunion in 18 Human Bones.
    JAMA Surg 2016 Nov 16;151(11):e162775. Epub 2016 Nov 16.
    Medical Affairs, Bioventus LLC, Durham, North Carolina.
    Importance: Failure of bone fracture healing occurs in 5% to 10% of all patients. Nonunion risk is associated with the severity of injury and with the surgical treatment technique, yet progression to nonunion is not fully explained by these risk factors.

    Objective: To test a hypothesis that fracture characteristics and patient-related risk factors assessable by the clinician at patient presentation can indicate the probability of fracture nonunion. Read More

    Vitamin D receptor gene associations with pulmonary tuberculosis in a Tibetan Chinese population.
    BMC Infect Dis 2016 Sep 5;16:469. Epub 2016 Sep 5.
    Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, 712082, China.
    Background: The vitamin D receptor (VDR) mediates the immunological function of vitamin D3, which activates macrophages, and vitamin D deficiency has been linked to tuberculosis risk. Single nucleotide polymorphisms (SNPs) in VDR may influence the function of vitamin D and susceptibility to tuberculosis.

    Methods: This study included 217 patients with pulmonary tuberculosis (PTB) and 383 healthy subjects in a Tibetan Chinese population living in and near Xi'an. Read More

    Vitamin D and the Pathogenesis of Inflammatory Bowel Disease.
    Curr Gastroenterol Rep 2016 Oct;18(10):52
    Division of Gastroenterology, University of California, Irvine, CA, USA.
    Vitamin D has traditionally been known for its role in bone metabolism, but emerging evidence has suggested a broader role for vitamin D in immune regulation. Vitamin D deficiency has been associated with the pathogenesis of diverse autoimmune disorders and has similarly been implicated as a contributor to inflammatory bowel disease. In this review, we discuss animal, in vitro, genetic, and epidemiologic studies that have linked vitamin D deficiency with inflammatory bowel disease pathogenesis or severity. Read More

    Geographical Variation in Dementia Mortality in Italy, New Zealand, and Chile: The Impact of Latitude, Vitamin D, and Air Pollution.
    Dement Geriatr Cogn Disord 2016 19;42(1-2):31-41. Epub 2016 Aug 19.
    Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.
    Background: Dementia risk is reported as being higher in the north compared to the south, which may be related to vitamin D deficiency. If this were the case, an opposite gradient of risk would be observed in the southern hemisphere, but this has not been investigated previously.

    Methods: We calculated standardised mortality ratios (SMRs) for deaths in 2012 where dementia (Alzheimer's disease, vascular or unspecified dementia) was recorded as the underlying cause for 20 regions in Italy, 20 District Health Board areas in New Zealand and 29 Health Service areas in Chile. Read More

    Effect of vitamin D3 on production of progesterone in porcine granulosa cells by regulation of steroidogenic enzymes.
    J Biomed Res 2016 May 20;30(3):203-8. Epub 2016 May 20.
    Department of Biomaterials Science, College of Natural Resources & Life Science, Pusan National University, Miryang 50463, Korea.
    1,25-dihydroxyvitamin D3 (VD3), an active form of Vitamin D, is photosynthesized in the skin of vertebrates in response to solar ultraviolet B radiation (UV-B). VD3 deficiency can cause health problems such as immune disease, metabolic disease, and bone disorders. It has also been demonstrated that VD3 is involved in reproductive functions. Read More

    [Chronic Kidney Disease and Bone].
    Clin Calcium 2016 Aug;26(8):1201-6
    Department of Nephrology and Hypertension, Fukushima Medical University, Japan.
    Both bone and kidney are members of the physiological network sharing a purpose of systemic mineral metabolism. In patients with chronic kidney disease whose kidney function is lost, the organ functions of other mineral metabolism network member including bone fail into uncontrollable due to dysregulated feedback system. This is the concept of Chronic Kidney Disease(related)- Mineral and Bone Disorder(CKD-MBD). Read More

    Vitamin D: not just bone, but also immunity.
    Minerva Med 2016 Dec 21;107(6):452-460. Epub 2016 Jul 21.
    Rheumatology Unit, University of Verona, Verona, Italy -
    Vitamin D should not be considered only as a vitamin. It has a relevant role in many functions of body regulation, both skeletal and extra skeletal and this makes vitamin D an essential element for a healthy status. This is well explained by a ubiquitous presence of vitamin D receptors. Read More

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