1,515 results match your criteria Vitamin D Deficiency and Related Disorders


Newborn vitamin D levels in relation to autism spectrum disorders and intellectual disability: A case-control study in california.

Autism Res 2019 Mar 18. Epub 2019 Mar 18.

Kaiser Permanente Division of Research, Oakland, California.

Vitamin D deficiency has been increasing concurrently with prevalence of autism spectrum disorders (ASD), and emerging evidence suggests vitamin D is involved in brain development. Most prior studies of ASD examined vitamin D levels in children already diagnosed, but a few examined levels during perinatal development, the more likely susceptibility period. Therefore, we examined newborn vitamin D levels in a case-control study conducted among births in 2000-2003 in southern California. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/aur.2092DOI Listing

Vitamin D Deficiency is Associated with Increased Use of Antimicrobials among Preschool Girls in Ethiopia.

Nutrients 2019 Mar 7;11(3). Epub 2019 Mar 7.

Department of Infectious Disease Immunology, Norwegian Institute of Public Health, 0456 Oslo, Norway.

Preschool children in Addis Ababa, Ethiopia, are highly exposed to influenza viruses. Factors related to infections, nutrition, and environmental conditions that might explain the burden of influenza among these children were investigated. Ninety-five preschool children, 48 girls and 47 boys, were followed clinically for 12 months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/nu11030575DOI Listing
March 2019
1 Read

Association of vitamin D deficiency and premature coronary artery disease.

Caspian J Intern Med 2019 ;10(1):80-85

Department of Pediatrics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Evidence suggests hypovitaminosis D is associated with increased risk of coronary artery disease (CAD) and its extent and related risk factors. However, some investigations have produced contrary results. Therefore, we aimed to evaluate the association between serum vitamin D levels and the severity of premature coronary artery involvement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.22088/cjim.10.1.80DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386332PMC
January 2019

Genetic Variation in Cytochrome P450 2R1 and Vitamin D Binding Protein Genes are associated with Vitamin D Deficiency in Adolescents.

Int J Vitam Nutr Res 2019 Mar 11:1-7. Epub 2019 Mar 11.

4 Physiology Department, Applied Physiology Research Center, Isfahan University of Medical Sciences, Iran.

Background: Genome Wide Association Studies (GWAS) have evaluated several genes related to vitamin D synthesis, metabolism and transport. They have proposed a genetic basis for low levels of vitamin D in the blood. The current study aims to investigate the relationship between certain vitamin D-associated gene variants and vitamin D deficiency in Iranian adolescents. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1024/0300-9831/a000509DOI Listing

North and south: A comprehensive analysis of non-adult growth and health in the industrial revolution (AD 18th-19th C), England.

Am J Phys Anthropol 2019 Mar 9. Epub 2019 Mar 9.

Department of Archaeology, Durham University, Durham, United Kingdom.

Objective: Stark health inequalities exist in the present day between the North and South of England, with people in the South, overall, experiencing better health across a range of parameters (e.g., life expectancy and number of years spent in good health). Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/ajpa.23817
Publisher Site
http://dx.doi.org/10.1002/ajpa.23817DOI Listing
March 2019
2 Reads

Parameters of Bone and Cardiovascular Health Related to 25-Hydroxyvitamin D Status in Emirati Nationals attending Primary Care and Diabetes services: a retrospective cohort study.

Sci Rep 2019 Mar 7;9(1):3835. Epub 2019 Mar 7.

Imperial College London Diabetes Centre, Research Department, Abu Dhabi, United Arab Emirates.

Vitamin D deficiency is endemic in people living in the Gulf states. We performed a retrospective analysis of data gathered at the first attendance of 82,396 Emirati nationals to outpatient diabetes, endocrinology and general primary care services at two centres in the United Arab Emirates during 2012-2016. Our aim was to explore associations between vitamin D status and markers of cardiovascular and bone health. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-40523-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405844PMC
March 2019
1 Read

Vitamin D and body mass index in Egyptian multiple sclerosis patients.

Mult Scler Relat Disord 2019 Feb 1;28:313-316. Epub 2018 Dec 1.

Neurology Department, Ain Shams University Cairo, Cairo, Egypt. Electronic address:

Background: Vitamin D deficiency and obesity may be related to the pathogenesis and disease activity of multiple sclerosis (MS). This study aimed to assess the correlation between the serum level of 25(OH) vitamin D, body mass index (BMI) and the Expanded Disability Status Scale (EDSS) in a sample of Egyptian MS patients.

Subjects And Methods: This was an observational study that included 130 MS patients who were recruited consecutively among the patients attending the MS unit of Ain Shams University Hospital, Cairo, in the period between December 2017 and March 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.msard.2018.11.035DOI Listing
February 2019

Association of Vitamin D Status With Liver and Kidney Disease: A Systematic Review of Clinical Trials, and Cross-Sectional and Cohort Studies.

Int J Vitam Nutr Res 2019 Feb 28:1-13. Epub 2019 Feb 28.

1 Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Vitamin D deficiency (VDD) is a major public health problem. There are few comprehensive systematic reviews about the relationship between Vitamin D status and liver and renal disease in Iran.

Methods: We systemically searched the following databases: Web of Science; PubMed; Cochrane Library; Scopus; Science Direct; Google Scholar and two Iranian databases (Scientific Information Database (SID) and IranMedex) up until November 2017 to identify all randomized control trials (RCTs), case control, cross-sectional and cohort studies investigating the association between vitamin D and any form of liver or kidney disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1024/0300-9831/a000540DOI Listing
February 2019
1 Read

FGF23 and its role in X-linked hypophosphatemia-related morbidity.

Orphanet J Rare Dis 2019 Feb 26;14(1):58. Epub 2019 Feb 26.

Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Background: X-linked hypophosphatemia (XLH) is an inherited disease of phosphate metabolism in which inactivating mutations of the Phosphate Regulating Endopeptidase Homolog, X-Linked (PHEX) gene lead to local and systemic effects including impaired growth, rickets, osteomalacia, bone abnormalities, bone pain, spontaneous dental abscesses, hearing difficulties, enthesopathy, osteoarthritis, and muscular dysfunction. Patients with XLH present with elevated levels of fibroblast growth factor 23 (FGF23), which is thought to mediate many of the aforementioned manifestations of the disease. Elevated FGF23 has also been observed in many other diseases of hypophosphatemia, and a range of animal models have been developed to study these diseases, yet the role of FGF23 in the pathophysiology of XLH is incompletely understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13023-019-1014-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390548PMC
February 2019
1 Read

Can YKL-40 be an Inflammatory Biomarker in Vitamin D Deficiency?

Int J Vitam Nutr Res 2019 Feb 26:1-5. Epub 2019 Feb 26.

4 Department of Internal Medicine, Konya Education and Research Hospital, Konya, Turkey.

Vitamin D deficiency is associated with several non-homeostatic conditions and/or diseases like inflammation, atherosclerosis, cardiovascular disease and mortality. YKL-40 is a glycoprotein, secreted by macrophages, neutrophils and different cell types and it is also associated with inflammation and pathological tissue remodeling. In this study, we aimed to evaluate relationship between the proinflammatory biomarkers YKL-40 and hs-CRP levels and vitamin D deficiency. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1024/0300-9831/a000545DOI Listing
February 2019
1 Read

Relationship between Serum Vitamin D Levels and Health-Related Quality of Life in Maintenance Hemodialysis Patients.

Blood Purif 2019 Feb 21:1-9. Epub 2019 Feb 21.

Department of Biostatistics, Faculty of Medicine, Erzincan University, Erzincan, Turkey.

Objectives: Aim of the study was investigating the effect of serum vitamin D levels on health-related quality of life in hemodialysis patients.

Method: One-hundred and twenty-three maintenance hemodialysis patients were enrolled in this cross-sectional study. Patients divided into 2 groups according to serum vitamin D levels. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000497242DOI Listing
February 2019
1 Read

Bone involvement in young adults with cystic fibrosis awaiting lung transplantation for end-stage respiratory failure.

Osteoporos Int 2019 Feb 23. Epub 2019 Feb 23.

Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.

Patients with cystic fibrosis awaiting lung transplantation for end-stage respiratory failure have high prevalence of reduced bone mineral density and fragility fracture. Suboptimal 25-hydroxyvitamin D levels could significantly contribute to the development of cystic fibrosis-related bone disease.

Introduction: The assessment of the prevalence of cystic fibrosis-related bone disease (CFBD) and its associated risk factors in young adults with cystic fibrosis (CF) awaiting lung transplantation for end-stage respiratory failure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00198-019-04893-zDOI Listing
February 2019
1 Read

Relationship Between Vitamin D Level and Bechcet's Disease Activity: A Systematic Review and Meta-Analysis.

Int J Vitam Nutr Res 2019 Feb 21:1-8. Epub 2019 Feb 21.

3 Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Aim: In the present study, the evidence about the association between vitamin D deficiency and Behcet's disease activity was systematically reviewed and meta-analyzed.

Method: We searched the English and Persian databases of Medline (Ovid), CINHAL, Scopus, Proquest, the Cochrane library and SID, IranDoc, Magiran, Iran Medex for articles published up until May 2018 with the keywords were related to serum vitamin D and active and inactive Behcet's disease in adults. Meta-analysis was done using the CMA software. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1024/0300-9831/a000542DOI Listing
February 2019

Different VDR, VDBP genotypes and vitamin D levels may effect obstructive sleep apnea syndrome.

Cell Mol Biol (Noisy-le-grand) 2019 Jan 31;65(1):46-51. Epub 2019 Jan 31.

Department of Medical Pharmacology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey.

Obstructive sleep apnea syndrome (OSAS) is a highly prevalent disorder which results in markedly reduced (hypopnea) or absent (apnea) airflow at the nose/mouth. Since vitamin D deficiency has found in an association with some disorders it is thought to be related with OSAS progression. The aim of this study is to investigate the association between VDR, VDBP mutations, vitamin D level and some environmental risk factors with OSAS. Read More

View Article

Download full-text PDF

Source
January 2019
1 Read

Metabolic and Endocrine Disorders in Pseudarthrosis.

Clin Spine Surg 2019 Feb 5. Epub 2019 Feb 5.

Departments of Orthopaedics and Rehabilitation.

Study Design: Retrospective Cohort.

Objective: Establish 1-year patient-reported outcomes after spine surgery for symptomatic pseudarthrosis compared with other indications. In the subgroup of pseudarthrosis patients, describe preexisting metabolic and endocrine-related disorders, and identify any new diagnoses or treatments initiated by an endocrine specialist. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/BSD.0000000000000788DOI Listing
February 2019
4 Reads

Cholecalciferol Supplementation Did Not Change Interleukin-7 and B cell-Activating Factor Levels and CD95 Expression in B lymphocytes in Patients on Dialysis: A Randomized Pilot-Controlled Trial.

J Ren Nutr 2019 Jan 24. Epub 2019 Jan 24.

Division of Nephrology- Universidade Federal São Paulo, UNIFESP, São Paulo, São Paulo, Brazil; Post-graduate Program in Medicine, Universidade Nove de Julho/UNINOVE, São Paulo, São Paulo, Brazil.

Background: End-stage renal disease results in B cell lymphopenia and low levels of vitamin D. Since the link between vitamin D deficiency and B lymphocytes dysfunction are not clear in patients with end-stage renal disease, we suggest that vitamin D adequacy and factors related to the homeostasis of these cells should be investigated. B lymphocytes homeostasis is a process mainly regulated signals of grown and death as interleukin (IL)-7, B cell-activating factor (BAFF)/BAFF-receptor and CD95 expression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.jrn.2018.11.006DOI Listing
January 2019
1 Read

Association of vitamin D levels and vitamin D-related gene polymorphisms with liver fibrosis in patients with biopsy-proven nonalcoholic fatty liver disease.

Dig Liver Dis 2019 Jan 9. Epub 2019 Jan 9.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.

Background: Vitamin D has promising anti-proliferative and anti-fibrotic properties, but its clinical utility in nonalcoholic fatty liver disease (NAFLD) is unclear.

Aims: This study aimed to clarify the association between vitamin D levels, single nucleotide polymorphisms (SNPs) in vitamin D-related genes, and the histopathological severity of disease in patients with biopsy-proven NAFLD.

Methods: SNPs in CYP2R1, DHCR7, vitamin D binding protein (GC), CYP27B1, and vitamin D receptor (VDR) were determined for 229 consecutive patients with biopsy-proven NAFLD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dld.2018.12.022DOI Listing
January 2019

Serum vitamin D deficiency and vitamin D receptor gene polymorphism are associated with increased risk of cardiovascular disease in a Chinese rural population.

Nutr Res 2019 01 13;61:13-21. Epub 2018 Sep 13.

Department of Nutrition and food hygiene, College of Public Health of Zhengzhou University, Zhengzhou, China, 450001. Electronic address:

Several studies have reported a conflicting association between vitamin D deficiency, vitamin D receptor (VDR) polymorphism, and the risk of cardiovascular disease (CVD). We hypothesized that serum 25(OH)D concentrations and single nucleotide polymorphisms (SNPs) of the VDR were associated with and increased risk of CVD. A total of 2378 adults residing in rural parts of China participated in this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nutres.2018.09.002DOI Listing
January 2019
1 Read

Relationship between Serum Vitamin D Levels and HDL Cholesterol in Postmenopausal Women from Colombian Caribbean.

J Nutr Metab 2018 20;2018:9638317. Epub 2018 Dec 20.

Grupo de Investigación Alimentación y Comportamiento Humano, Nutrition and Diet Program, Metropolitana University, Career 42F No. 75B-18, Barranquilla, Colombia.

Background: Previous evidence suggests that metabolic disorders in postmenopausal women could be related with low serum vitamin D levels. For example, vitamin D deficiency has been associated with increased risk factors for cardiovascular disease (CVD), mainly those related with metabolic syndrome.

Objective: To assess the relationship between the serum vitamin D (25-OH-D) levels and the metabolic syndrome markers in postmenopausal women. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2018/9638317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317087PMC
December 2018
2 Reads

Comprehensive Review on Diabetes Associated Cardiovascular Complications - The Vitamin D Perspective.

Cardiovasc Hematol Disord Drug Targets 2019 Jan 14. Epub 2019 Jan 14.

Department of Biochemistry, Kasturba Medical College, Manipal Academy of Higher Education, Mangaluru, Karnataka. India.

Vitamin D, a steroid hormone is primarily known for its role in calcium and bone mineral homeostasis. Over the years, vitamin D has been implicated in various non-skeletal diseases. The extraskeletal phenomenon can be attributed to the presence of vitamin D receptors (VDRs) in almost all cells and identification of 1-α hydroxylase in extrarenal tissues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1871529X19666190114155302DOI Listing
January 2019
6 Reads

Vitamin D serum concentration is not related to the activity of spondyloarthritis - preliminary study.

Reumatologia 2018 23;56(6):388-391. Epub 2018 Dec 23.

Department of Rheumatology and Balneology, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland.

Objective: Vitamin D plays an important role in mineral turnover and bone remodeling and there are increasing data about its immunomodulatory potential in different rheumatologic disorders. Deficiency of vitamin D is frequent in patients with spondyloarthritis (SpA) and some data suggest its association with increased disease activity and structural damage. However, its exact role in the pathogenesis of SpA and its association with disease activity are still a matter of debate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5114/reum.2018.80717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330676PMC
December 2018
3 Reads

Association of Vitamin D Status with Chronic Disease Risk Factors and Cognitive Dysfunction in 50⁻70 Year Old Adults.

Nutrients 2019 Jan 11;11(1). Epub 2019 Jan 11.

Department of Health and Exercise Science, University of Oklahoma, Norman, OK 73019, USA.

Vitamin D deficiency/insufficiency has been primarily associated with skeletal disorders, however, since vitamin D receptors are found on multiple types of cells, there is also a link to increased chronic disease risk and all-cause mortality. The aim of this study was to examine whether deficient/insufficient vitamin D levels are associated with risk factors of chronic diseases and cognitive dysfunction in 50 to 70 year old adults. Participants completed the health status, three-day dietary record and vitamin D food frequency, sun exposure, and international physical activity questionnaires. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/nu11010141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357287PMC
January 2019

Vitamin D: part II; cod liver oil, ultraviolet radiation, and eradication of rickets.

Int Orthop 2019 Mar 9;43(3):735-749. Epub 2019 Jan 9.

Hôpital Henri Mondor, 94010, Creteil, France.

Purpose: After Glisson's description of rickets, it took two centuries to realize that rickets was due to the absence of antirachitic nutrients in the diet or lack exposure of the skin to ultraviolet rays. This bone disease caused by vitamin D deficiency was one of the most common diseases of children 100 years ago. This paper explores how the definition, diagnosis, and treatment of rickets shifted in the first decades of the twentieth century. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00264-019-04288-zDOI Listing
March 2019
5 Reads

An Argument for Vitamin D, A, and Zinc Monitoring in Cirrhosis.

Ann Hepatol 2018 Oct;17(6):920-932

Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL, USA.

Malnutrition is prevalent in cirrhosis. Vitamin and mineral deficiencies, including vitamin D, vitamin A, and zinc, are common and have been shown to correlate with survival. Our aim was to review the mechanisms of vitamin D, vitamin A, and zinc deficiencies in cirrhosis and the clinical assessment of affected patients, their outcomes based on the current literature, and management. Read More

View Article

Download full-text PDF

Source
https://annalsofhepatology.publisherspanel.com/gicid/01.3001
Publisher Site
http://dx.doi.org/10.5604/01.3001.0012.7192DOI Listing
October 2018
4 Reads

Was the Last Ice Age dusty climate instrumental in spreading of the three "Celtic" diseases (hemochromatosis, cystic fibrosis and palmar fibromatosis)?

Authors:
Sven Kurbel

Med Hypotheses 2019 Jan 20;122:134-138. Epub 2018 Nov 20.

Faculty of Dental Medicine and Health Osijek, Crkvena 21, HR-31000 Osijek, Croatia; Polyclinic Aviva, Nemetova 2, Zagreb, Croatia. Electronic address:

Cystic fibrosis, hereditary hemochromatosis and palmar fibromatosis are often described as "Celtic", based on their contemporary prevalence. The former two are among genetically defined disorders that seem to provide survival advantages to heterozygote individuals, while severe health problems happen in homozygote mutation carriers. Although palmar fibromatosis has no defined mutations, its prevalence has been linked to the prevalence of Y-Chromosome Haplogroup I that expanded after the Last Ice Age, thus making th distribution of all three "Celtic" diseases dependent on the global climate from 40 to 8 Kya. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2018.11.006DOI Listing
January 2019
3 Reads

Association of Low Vitamin D Status with Complications of HIV and AIDS: A Literature Review.

Infect Disord Drug Targets 2018 Dec 21. Epub 2018 Dec 21.

Department HIV Medicine, Coventry & Warwickshire Partnership Trust. United Kingdom.

With the advent of combination antiretroviral therapy (cART) the survival of HIV patients have improved dramatically, but the complications of the disease and treatment have become an important issue in the management of HIV patients. Vitamin-D deficiency is common in HIV patients. Low vitamin-D is associated with different comorbidities in the HIV uninfected general population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1871526519666181221122731DOI Listing
December 2018
2 Reads

Evaluation of vitamin D deficiency: A population-based study in northeastern Iran.

J Cell Biochem 2018 Dec 16. Epub 2018 Dec 16.

Department of Immunology, Bu-Ali Research Institute, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Background And Aim: In recent years, vitamin D deficiency has become a major worldwide problem that can exert harmful effects. The aim of the present study was to evaluate the sex- and age-related prevalence of vitamin D deficiency in people from Mashhad, northeastern Iran.

Methods: In this cross-sectional study conducted over a period of 1 year (2015-2016), 7504 subjects who referred to Mashhad medical centers were randomly enrolled in the study. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28317
Publisher Site
http://dx.doi.org/10.1002/jcb.28317DOI Listing
December 2018
11 Reads
3.263 Impact Factor

Omega-3 PUFAs and vitamin D co-supplementation as a safe-effective therapeutic approach for core symptoms of autism spectrum disorder: case report and literature review.

Nutr Neurosci 2018 Dec 13:1-12. Epub 2018 Dec 13.

a Unit of Endocrinology and Metabolic Diseases, Department of Systems Medicine , CTO Andrea Alesini Hospital, University Tor Vergata , Rome , Italy.

Introduction: Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by abnormal development of cognitive, social, and communicative skills. Although ASD aetiology and pathophysiology are still unclear, various nutritional factors have been investigated as potential risk factors for ASD development, including omega-3 polyunsaturated fatty acids (PUFAs) and vitamin D deficiency. In fact, both omega-3 PUFAs and vitamin D are important for brain development and function. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1028415X.2018.1557385DOI Listing
December 2018

The association between neonatal vitamin D status and risk of schizophrenia.

Sci Rep 2018 Dec 6;8(1):17692. Epub 2018 Dec 6.

Queensland Brain Institute, University of Queensland, St. Lucia, Queensland, Australia.

Clues from the epidemiology of schizophrenia, such as the increased risk in those born in winter/spring, have led to the hypothesis that prenatal vitamin D deficiency may increase the risk of later schizophrenia. We wish to explore this hypothesis in a large Danish case-control study (n = 2602). The concentration of 25 hydroxyvitamin D (25OHD) was assessed from neonatal dried blood samples. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-35418-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283870PMC
December 2018
2 Reads

Vitamin D status in Kancheepuram District, Tamil Nadu, India.

BMC Public Health 2018 Dec 5;18(1):1345. Epub 2018 Dec 5.

SRM Institute of Gastroenterology, Hepatobiliary Sciences & Transplantation, SIMS Hospital, Jawaharlal Nehru Road, Vadapalani, Chennai, Tamil Nadu, India.

Background: Vitamin D has multifarious roles in maintenance of health and prevention of disease. The present study was undertaken to assess the vitamin D status of a rural adult south Indian population and to identify its associations with socioeconomic status and cultural practices.

Methods: Between June 2015 and July 2016, 424 healthy adults residing in Kattankulathur block in Tamil Nadu, India, provided venous blood samples and answered questions by personal interview. Read More

View Article

Download full-text PDF

Source
https://bmcpublichealth.biomedcentral.com/articles/10.1186/s
Publisher Site
http://dx.doi.org/10.1186/s12889-018-6244-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280507PMC
December 2018
13 Reads
2.264 Impact Factor

Inhibitory effects of chronic administration of vitamin D on pentylenetetrazole-induced seizures in mice.

Epilepsy Res 2019 01 28;149:76-82. Epub 2018 Nov 28.

Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran; Department of Pharmacology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran. Electronic address:

Vitamin D as a neuroactive steroid hormone plays an important role in the nervous system. Recent clinical and experimental studies have shown an association between vitamin D-related disorders and epilepsy. Therefore, this study was designed to examine the effects of chronic administration of vitamin D on pentylenetetrazole (PTZ)-induced seizure in mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eplepsyres.2018.11.011DOI Listing
January 2019
2 Reads

Vitamin D and Gastrointestinal Cancers: A Narrative Review.

Dig Dis Sci 2018 Dec 3. Epub 2018 Dec 3.

Section of Clinical Biochemistry, University of Verona, Verona, Italy.

Calcitriol (1,25(OH)D) performs various activities throughout the body. Although low serum 25-hydroxyvitamin D [25(OH)D] levels are associated with several disease processes such as risk of fractures and falls, hypertension, cardiovascular disease, and diabetes mellitus, recent evidence attests that this important hormone also regulates several cellular pathways involved in cancer development and progression. Calcitriol modulates several genes controlling gut physiology and calcium homeostasis and also maintains the integrity of epithelial barriers, regulates the absorption of phosphate and calcium, and modulates host defense against pathogens and inflammatory response by interplaying with several types of secretory and immune cells. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s10620-018-5400-1
Publisher Site
http://dx.doi.org/10.1007/s10620-018-5400-1DOI Listing
December 2018
17 Reads
2.550 Impact Factor

Severe vitamin D deficiency is a prognostic biomarker in autoimmune hepatitis.

Aliment Pharmacol Ther 2019 Jan 28;49(2):173-182. Epub 2018 Nov 28.

Division of Gastroenterology & Liver Unit, University of Alberta Hospital, Edmonton, AB, Canada.

Background: Vitamin D deficiency has been implicated in the outcome of chronic liver disease.

Aim: To determine the frequency of severe vitamin D deficiency in autoimmune hepatitis (AIH), assess its association with treatment non-response, and evaluate the relationship between vitamin D status and liver-related mortality and need for transplantation.

Methods: Two hundred and nine patients were evaluated by liver tissue examination at presentation. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/apt.15029
Publisher Site
http://dx.doi.org/10.1111/apt.15029DOI Listing
January 2019
6 Reads

Vitamin D supplementation in patients with nonalcoholic fatty liver disease: A randomized controlled trial.

JGH Open 2017 Oct 12;1(2):62-67. Epub 2017 Oct 12.

Department of Hepatology Postgraduate Institute of Medical Education and Research Chandigarh India.

Background And Aim: Deficiency of vitamin D may be related to the pathogenesis of nonalcoholic fatty liver disease (NAFLD). The aim of the present study was to evaluate the effect of vitamin D supplementation in patients with NAFLD.

Methods: A total of 81 patients with NAFLD with normal or raised ( = 47) serum alanine aminotransferase (ALT) having vitamin D deficiency were randomized prospectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jgh3.12010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207029PMC
October 2017
2 Reads

Sarcopenia in patients with non-alcoholic fatty liver disease: is it a clinically significant entity?

Obes Rev 2019 02 25;20(2):353-363. Epub 2018 Nov 25.

Laboratory of Experimental Medicine and Paediatrics (LEMP), University of Antwerp, Wilrijk (Antwerp), Belgium.

Sarcopenia, described as the loss of muscle mass and/or strength, is gaining importance as it can be increasingly related to many chronic diseases. It is also associated with chronic liver disease, and recently it has been more frequently linked to non-alcoholic fatty liver disease (NAFLD) in particular. Both sarcopenia and NAFLD are subject to complex and intermingled pathophysiological processes, of which some are in common. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/obr.12776
Publisher Site
http://dx.doi.org/10.1111/obr.12776DOI Listing
February 2019
10 Reads

Vitamin D and cardiometabolic disorders: a review of current evidence, genetic determinants and pathomechanisms.

Obes Rev 2019 02 18;20(2):262-277. Epub 2018 Nov 18.

Monash Centre for Health Research and Implementation (MCHRI), School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.

Vitamin D deficiency has been implicated in the pathophysiology of cardiometabolic disorders including obesity, type 2 diabetes mellitus, cardiovascular diseases and polycystic ovary syndrome. Despite a large number of experimental and observational studies supporting a role for vitamin D in these pathologies, randomized controlled trials have reported little to no effect of vitamin D supplementation in the prevention or treatment of these disorders, although some results remain ambiguous. Polymorphisms in genes related to vitamin D metabolism, particularly in the vitamin D receptor and binding protein and the metabolizing enzyme 1-α-hydroxylase, have emerged as potential contributors to these divergent results. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/obr.12793DOI Listing
February 2019
2 Reads

Airway infection with Nontypeable Haemophilus influenzae is more rapidly eradicated in vitamin D deficient mice.

J Steroid Biochem Mol Biol 2019 Mar 3;187:42-51. Epub 2018 Nov 3.

Laboratory of Respiratory Diseases, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium. Electronic address:

Chronic obstructive pulmonary disease (COPD), which is characterized by an excessive inflammatory response of the airways, is often complicated by exacerbations. Vitamin D deficiency has been associated with an increased risk for COPD and may predispose COPD patients to a higher exacerbation rate, particularly during smoking. In the current study, we investigated the effect of vitamin D deficiency and cigarette smoke (CS)-exposure on lung inflammation and bacterial clearance after an acute infection with Nontypeable Haemophilus influenzae (NTHi). Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09600760183045
Publisher Site
http://dx.doi.org/10.1016/j.jsbmb.2018.10.021DOI Listing
March 2019
12 Reads

Association of Vitamin D Deficiency with Increased Pulse Wave Velocity and Augmentation Index in Children With Chronic Kidney Disease.

Iran J Kidney Dis 2018 Oct;12(5):275-280

Ege University Faculty of Medicine, Department of Pediatric Nephrology, ?zmir, Turkey.

Introduction: It is known that in children with chronic kidney disease (CKD), cardiovascular damage starts in the form of arterial stiffness. There are risk factors other than the traditional ones such as arterial stiffness hypertension, obesity, hypercholesterolemia, and insulin resistance. Vitamin D deficiency is rather common in CKD, and it was introduced as a risk factor for atherosclerosis; however, its relationship with arterial stiffness is not known completely. Read More

View Article

Download full-text PDF

Source
October 2018
15 Reads

Association between Vitamin D Levels and Nonalcoholic Fatty Liver Disease: Potential Confounding Variables.

Mini Rev Med Chem 2019 ;19(4):310-332

Institute of Translational Pharmacology, National Research Council, Via Fosso del Cavaliere, 100 00133- Rome, Italy.

Nonalcoholic fatty liver disease (NAFLD), historically considered to be the hepatic component of the metabolic syndrome, is a spectrum of fat-associated liver conditions, in the absence of secondary causes, that may progress to nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. Disease progression is closely associated with body weight or fatness, dyslipidemia, insulin resistance, oxidative stress, and inflammation. Recently, vitamin D deficiency has been linked to the pathogenesis and severity of NAFLD because of vitamin D "pleiotropic" functions, with roles in immune modulation, cell differentiation and proliferation, and regulation of inflammation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1389557518666181025153712DOI Listing
March 2019
3 Reads

Vitamin D Deficiency and Immune Disorders in Combined Endocrine Pathology.

Front Endocrinol (Lausanne) 2018 9;9:600. Epub 2018 Oct 9.

Endocrinology Department, Bogomolets National Medical University, Kyiv, Ukraine.

Combined endocrine pathology is a serious healthcare problem in Ukraine. This prospective study assessed the blood levels of 25-hydroxyvitamin D [25(OH)D] and markers of immune function in response to vitamin D intervention in patients with type 1 and type 2 diabetes mellitus (T1DM and T2DM, respectively) and autoimmune thyroiditis (AIT). This study evaluated the relationship between the metabolic and immune status of DM + AIT patients with respect to their vitamin D status and changes after vitamin D supplementation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fendo.2018.00600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190873PMC
October 2018
1 Read

Treatment of Vitamin D Deficiency and Comorbidities: A Review.

Authors:
Parminder Singh

J Assoc Physicians India 2018 01;66(1):75-82

Professor and the Head of Department- Endocrinology, Dayanand Medical College and Hospital, Ludhiana, Punjab.

Vitamin D is essential for the maintenance of calcium and phosphorus homeostasis, skeletal growth and various other metabolic processes. The prevalence of vitamin D deficiency in India is 50-90% in various studies. Factors such as low sunlight exposure, age-related decrease in cutaneous synthesis, and low dietary intake of vitamin D contribute to the high prevalence of vitamin D inadequacy which has emerged as a highly pervasive condition. Read More

View Article

Download full-text PDF

Source
January 2018
15 Reads

Vitamin D status and its management for achieving optimal health benefits in the elderly.

Expert Rev Endocrinol Metab 2018 Nov 14;13(6):279-293. Epub 2018 Oct 14.

a Blizard Institute , Queen Mary University London , London , UK.

Introduction: Vitamin D deficiency is common, world-wide, but vitamin D repletion throughout life, and into older age, has accepted health benefits for bone. Many mechanisms through which vitamin D also benefits soft tissues are understood, and clinical evidence of such benefits is now accumulating, especially following re-analyses of trial data, which are revealing previously missed health benefits with correction of deficiency. Areas covered: The sources of vitamin D, its activation, mechanistic effects; problems of trials of supplementation for reducing health risks, the benefits shown for mortality, cardiovascular disease, infection and cancer; the global problem of vitamin D deficiency; age-related reductions in vitamin D efficacy, and currently recommended intakes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17446651.2018.1533401DOI Listing
November 2018

Serum vitamin D level and its relation to thyroid hormone, blood sugar and lipid profiles in Iranian sedentary work staff.

Nutr Hosp 2018 Oct 5;35(5):1107-1114. Epub 2018 Oct 5.

Introduction: the sedentary lifestyle is related to the incidence of various diseases and metabolic disorders. The aim of the current study was to understand the link between serum vitamin D levels, thyroid hormones and lipid profiles among Iranian sedentary staff.

Material And Methods: in this cross-sectional study, 300 healthy subjects with normal body mass index (BMI) and age between 18 and 65 years, with sedentary lifestyles, were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.20960/nh.1719DOI Listing
October 2018
4 Reads
1.250 Impact Factor

Mineral bone disorders in chronic kidney disease.

Nephrology (Carlton) 2018 Oct;23 Suppl 4:88-94

Department of Medicine, Fu-Jen Catholic University Hospital, College of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan.

As the GFR loss aggravates, the disturbed mineral metabolism worsens the bone microstructure and remodelling - scenario, which is known as CKD-mineral bone disease (MBD). CKD-MBD is characterized by : (i) abnormal metabolism of calcium, phosphorus, parathyroid hormone (PTH), or vitamin D; (ii) abnormalities in bone turnover, mineralization, volume linear growth or strength; (iii) soft-tissue calcifications, either vascular or extra-osseous. Uremic vascular calcification and osteoporosis are the most common complications related to CKD-MBD. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/nep.13457
Publisher Site
http://dx.doi.org/10.1111/nep.13457DOI Listing
October 2018
16 Reads

Association of Serum Vitamin D Concentration With Clinical Symptoms and Quality of Life in Patients With Irritable Bowel Syndrome.

J Am Coll Nutr 2018 Sep 25:1-7. Epub 2018 Sep 25.

a Department of Nutrition , Nutritional Health Research Center, Lorestan University of Medical Sciences , Khorramabad , Iran.

Objective: A high prevalence of vitamin D deficiency (VDD) in gastrointestinal (GI) disorders and the role of vitamin D in the function of the gut have been shown previously. Therefore, we aimed to evaluated the VDD and the possible association of the GI symptoms severity and quality of life (QoL) score with the serum levels of vitamin D in irritable bowel syndrome (IBS).

Methods: A total of 90 patients with IBS based on Rome III criteria enrolled in the study from the tertiary referral university hospital. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/07315724.2018.1510349DOI Listing
September 2018
2 Reads

Investigation of the Relationship Between and Gene Polymorphisms and Development of Treatment-Related Bone Complications in Children with Acute Lymphoblastic Leukemia

Turk J Haematol 2019 02 25;36(1):12-18. Epub 2018 Sep 25.

Dokuz Eylül University Faculty of Medicine, Department of Pediatric Hematology, İzmir, Turkey

Objective: In acute lymphoblastic leukemia (ALL), various clinical risk factors and genetic predispositions contribute to the development of bone complications during and after chemotherapy. In this study, we aimed to investigate whether vitamin D receptor () and collagen protein Sp1-binding site gene polymorphisms, which are important in bone mineral and matrix formation, have effects on the development of bone abnormalities in childhood ALL survivors.

Materials And Methods: Fifty children with ALL who were treated with the ALL Berlin-Frankfurt-Muenster-95 protocol between 1998 and 2008 and were followed for at least 7 years were enrolled. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4274/tjh.galenos.2018.2018.0221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373515PMC
February 2019
3 Reads
0.340 Impact Factor

Linking of psoriasis with osteopenia and osteoporosis: A cross-sectional study.

Indian J Dermatol Venereol Leprol 2019 Mar-Apr;85(2):153-159

General Dermatology Department, Dermatology Unit, Virgin de las Nieves University Hospital; Dermatology Department, Medicine School of the University of Granada, Granada, Spain.

Background/purpose: Psoriasis is a multisystem disease which has been related to vitamin-D deficiency through chronic inflammation. This psoriasis-related inflammatory state and vitamin-D deficiency may induce bone mineral density loss. The purpose of this study is to assess the relationship of psoriasis with bone mineral density, by comparing psoriatic patients with healthy controls and patients with osteopenia/osteoporosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijdvl.IJDVL_831_17DOI Listing
September 2018
10 Reads

Global prevalence and disease burden of vitamin D deficiency: a roadmap for action in low- and middle-income countries.

Ann N Y Acad Sci 2018 10 18;1430(1):44-79. Epub 2018 Sep 18.

University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Vitamin D is an essential nutrient for bone health and may influence the risks of respiratory illness, adverse pregnancy outcomes, and chronic diseases of adulthood. Because many countries have a relatively low supply of foods rich in vitamin D and inadequate exposure to natural ultraviolet B (UVB) radiation from sunlight, an important proportion of the global population is at risk of vitamin D deficiency. There is general agreement that the minimum serum/plasma 25-hydroxyvitamin D concentration (25(OH)D) that protects against vitamin D deficiency-related bone disease is approximately 30 nmol/L; therefore, this threshold is suitable to define vitamin D deficiency in population surveys. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.13968DOI Listing
October 2018
2 Reads
4.313 Impact Factor

Vitamin D Intake and Status of Children With Sickle Cell Disease in Montreal, Canada.

J Pediatr Hematol Oncol 2018 Nov;40(8):e531-e536

Department of Nutrition, Université de Montréal.

Sickle cell disease (SCD) and vitamin D deficiency share manifestations such as bone complications and bony pains. Canadian SCD children are characterized by compromised sun exposure all year long and potential dietary deficiency, which combined to SCD-causing high nutritional demands, may lead to impaired vitamin D status. The objectives of this study were to document vitamin D status and intake and assess the relationship between vitamin D status and SCD-related outcomes in Canadian children with SCD followed in a tertiary pediatric center. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MPH.0000000000001306DOI Listing
November 2018
12 Reads

Assessment of Biochemical and Densitometric Markers of Calcium-Phosphate Metabolism in the Groups of Patients with Multiple Sclerosis Selected due to the Serum Level of Vitamin D.

Biomed Res Int 2018 23;2018:9329123. Epub 2018 Aug 23.

Department of Neurology, SMDZ in Zabrze, Medical University of Silesia in Katowice, ul. 3-go Maja 13-15, 41-800 Zabrze, Poland.

Background: In addition to the widely known effect of vitamin D (vitD) on the skeleton, its role in the regulation of the immune response was also confirmed.

Aim: The assessment of biochemical and densitometric markers of calcium-phosphate metabolism in the groups of patients with relapsing-remitting multiple sclerosis (RRMS) selected due to the serum level of vitamin D.

Methods: The concentrations of biochemical markers and indices of lumbar spine bone densitometry (DXA) were determined in 82 patients divided into vitamin D deficiency (VitDd), insufficiency (VitDi), and normal vitamin D level (VitDn) subgroups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2018/9329123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126066PMC
January 2019
3 Reads