1,475 results match your criteria Vitamin D Deficiency and Related Disorders


Vitamin D: part II; cod liver oil, ultraviolet radiation, and eradication of rickets.

Int Orthop 2019 Jan 9. Epub 2019 Jan 9.

Hôpital Henri Mondor, 94010, Creteil, France.

Purpose: After Glisson's description of rickets, it took two centuries to realize that rickets was due to the absence of antirachitic nutrients in the diet or lack exposure of the skin to ultraviolet rays. This bone disease caused by vitamin D deficiency was one of the most common diseases of children 100 years ago. This paper explores how the definition, diagnosis, and treatment of rickets shifted in the first decades of the twentieth century. Read More

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http://dx.doi.org/10.1007/s00264-019-04288-zDOI Listing
January 2019

An Argument for Vitamin D, A, and Zinc Monitoring in Cirrhosis.

Ann Hepatol 2018 Oct;17(6):920-932

Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL, USA.

Malnutrition is prevalent in cirrhosis. Vitamin and mineral deficiencies, including vitamin D, vitamin A, and zinc, are common and have been shown to correlate with survival. Our aim was to review the mechanisms of vitamin D, vitamin A, and zinc deficiencies in cirrhosis and the clinical assessment of affected patients, their outcomes based on the current literature, and management. Read More

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https://annalsofhepatology.publisherspanel.com/gicid/01.3001
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http://dx.doi.org/10.5604/01.3001.0012.7192DOI Listing
October 2018
2 Reads

Was the Last Ice Age dusty climate instrumental in spreading of the three "Celtic" diseases (hemochromatosis, cystic fibrosis and palmar fibromatosis)?

Authors:
Sven Kurbel

Med Hypotheses 2019 Jan 20;122:134-138. Epub 2018 Nov 20.

Faculty of Dental Medicine and Health Osijek, Crkvena 21, HR-31000 Osijek, Croatia; Polyclinic Aviva, Nemetova 2, Zagreb, Croatia. Electronic address:

Cystic fibrosis, hereditary hemochromatosis and palmar fibromatosis are often described as "Celtic", based on their contemporary prevalence. The former two are among genetically defined disorders that seem to provide survival advantages to heterozygote individuals, while severe health problems happen in homozygote mutation carriers. Although palmar fibromatosis has no defined mutations, its prevalence has been linked to the prevalence of Y-Chromosome Haplogroup I that expanded after the Last Ice Age, thus making th distribution of all three "Celtic" diseases dependent on the global climate from 40 to 8 Kya. Read More

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http://dx.doi.org/10.1016/j.mehy.2018.11.006DOI Listing
January 2019
1 Read

Association of Low Vitamin D Status with Complications of HIV and AIDS: A Literature Review.

Infect Disord Drug Targets 2018 Dec 21. Epub 2018 Dec 21.

Department HIV Medicine, Coventry & Warwickshire Partnership Trust. United Kingdom.

With the advent of combination antiretroviral therapy (cART) the survival of HIV patients have improved dramatically, but the complications of the disease and treatment have become an important issue in the management of HIV patients. Vitamin-D deficiency is common in HIV patients. Low vitamin-D is associated with different comorbidities in the HIV uninfected general population. Read More

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http://dx.doi.org/10.2174/1871526519666181221122731DOI Listing
December 2018

Evaluation of vitamin D deficiency: A population-based study in northeastern Iran.

J Cell Biochem 2018 Dec 16. Epub 2018 Dec 16.

Department of Immunology, Bu-Ali Research Institute, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Background And Aim: In recent years, vitamin D deficiency has become a major worldwide problem that can exert harmful effects. The aim of the present study was to evaluate the sex- and age-related prevalence of vitamin D deficiency in people from Mashhad, northeastern Iran.

Methods: In this cross-sectional study conducted over a period of 1 year (2015-2016), 7504 subjects who referred to Mashhad medical centers were randomly enrolled in the study. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28317
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http://dx.doi.org/10.1002/jcb.28317DOI Listing
December 2018
5 Reads
3.263 Impact Factor

Omega-3 PUFAs and vitamin D co-supplementation as a safe-effective therapeutic approach for core symptoms of autism spectrum disorder: case report and literature review.

Nutr Neurosci 2018 Dec 13:1-12. Epub 2018 Dec 13.

a Unit of Endocrinology and Metabolic Diseases, Department of Systems Medicine , CTO Andrea Alesini Hospital, University Tor Vergata , Rome , Italy.

Introduction: Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by abnormal development of cognitive, social, and communicative skills. Although ASD aetiology and pathophysiology are still unclear, various nutritional factors have been investigated as potential risk factors for ASD development, including omega-3 polyunsaturated fatty acids (PUFAs) and vitamin D deficiency. In fact, both omega-3 PUFAs and vitamin D are important for brain development and function. Read More

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http://dx.doi.org/10.1080/1028415X.2018.1557385DOI Listing
December 2018

The association between neonatal vitamin D status and risk of schizophrenia.

Sci Rep 2018 Dec 6;8(1):17692. Epub 2018 Dec 6.

Queensland Brain Institute, University of Queensland, St. Lucia, Queensland, Australia.

Clues from the epidemiology of schizophrenia, such as the increased risk in those born in winter/spring, have led to the hypothesis that prenatal vitamin D deficiency may increase the risk of later schizophrenia. We wish to explore this hypothesis in a large Danish case-control study (n = 2602). The concentration of 25 hydroxyvitamin D (25OHD) was assessed from neonatal dried blood samples. Read More

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http://dx.doi.org/10.1038/s41598-018-35418-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283870PMC
December 2018

Inhibitory effects of chronic administration of vitamin D on pentylenetetrazole-induced seizures in mice.

Epilepsy Res 2019 Jan 28;149:76-82. Epub 2018 Nov 28.

Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran; Department of Pharmacology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran. Electronic address:

Vitamin D as a neuroactive steroid hormone plays an important role in the nervous system. Recent clinical and experimental studies have shown an association between vitamin D-related disorders and epilepsy. Therefore, this study was designed to examine the effects of chronic administration of vitamin D on pentylenetetrazole (PTZ)-induced seizure in mice. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.11.011DOI Listing
January 2019
1 Read

Vitamin D and Gastrointestinal Cancers: A Narrative Review.

Dig Dis Sci 2018 Dec 3. Epub 2018 Dec 3.

Section of Clinical Biochemistry, University of Verona, Verona, Italy.

Calcitriol (1,25(OH)D) performs various activities throughout the body. Although low serum 25-hydroxyvitamin D [25(OH)D] levels are associated with several disease processes such as risk of fractures and falls, hypertension, cardiovascular disease, and diabetes mellitus, recent evidence attests that this important hormone also regulates several cellular pathways involved in cancer development and progression. Calcitriol modulates several genes controlling gut physiology and calcium homeostasis and also maintains the integrity of epithelial barriers, regulates the absorption of phosphate and calcium, and modulates host defense against pathogens and inflammatory response by interplaying with several types of secretory and immune cells. Read More

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http://link.springer.com/10.1007/s10620-018-5400-1
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http://dx.doi.org/10.1007/s10620-018-5400-1DOI Listing
December 2018
6 Reads
2.550 Impact Factor

Severe vitamin D deficiency is a prognostic biomarker in autoimmune hepatitis.

Aliment Pharmacol Ther 2019 Jan 28;49(2):173-182. Epub 2018 Nov 28.

Division of Gastroenterology & Liver Unit, University of Alberta Hospital, Edmonton, AB, Canada.

Background: Vitamin D deficiency has been implicated in the outcome of chronic liver disease.

Aim: To determine the frequency of severe vitamin D deficiency in autoimmune hepatitis (AIH), assess its association with treatment non-response, and evaluate the relationship between vitamin D status and liver-related mortality and need for transplantation.

Methods: Two hundred and nine patients were evaluated by liver tissue examination at presentation. Read More

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http://doi.wiley.com/10.1111/apt.15029
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http://dx.doi.org/10.1111/apt.15029DOI Listing
January 2019
3 Reads

Vitamin D supplementation in patients with nonalcoholic fatty liver disease: A randomized controlled trial.

JGH Open 2017 Oct 12;1(2):62-67. Epub 2017 Oct 12.

Department of Hepatology Postgraduate Institute of Medical Education and Research Chandigarh India.

Background And Aim: Deficiency of vitamin D may be related to the pathogenesis of nonalcoholic fatty liver disease (NAFLD). The aim of the present study was to evaluate the effect of vitamin D supplementation in patients with NAFLD.

Methods: A total of 81 patients with NAFLD with normal or raised ( = 47) serum alanine aminotransferase (ALT) having vitamin D deficiency were randomized prospectively. Read More

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http://dx.doi.org/10.1002/jgh3.12010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207029PMC
October 2017

Sarcopenia in patients with non-alcoholic fatty liver disease: is it a clinically significant entity?

Obes Rev 2019 Feb 25;20(2):353-363. Epub 2018 Nov 25.

Laboratory of Experimental Medicine and Paediatrics (LEMP), University of Antwerp, Wilrijk (Antwerp), Belgium.

Sarcopenia, described as the loss of muscle mass and/or strength, is gaining importance as it can be increasingly related to many chronic diseases. It is also associated with chronic liver disease, and recently it has been more frequently linked to non-alcoholic fatty liver disease (NAFLD) in particular. Both sarcopenia and NAFLD are subject to complex and intermingled pathophysiological processes, of which some are in common. Read More

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http://doi.wiley.com/10.1111/obr.12776
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http://dx.doi.org/10.1111/obr.12776DOI Listing
February 2019
5 Reads

Vitamin D and cardiometabolic disorders: a review of current evidence, genetic determinants and pathomechanisms.

Obes Rev 2019 Feb 18;20(2):262-277. Epub 2018 Nov 18.

Monash Centre for Health Research and Implementation (MCHRI), School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.

Vitamin D deficiency has been implicated in the pathophysiology of cardiometabolic disorders including obesity, type 2 diabetes mellitus, cardiovascular diseases and polycystic ovary syndrome. Despite a large number of experimental and observational studies supporting a role for vitamin D in these pathologies, randomized controlled trials have reported little to no effect of vitamin D supplementation in the prevention or treatment of these disorders, although some results remain ambiguous. Polymorphisms in genes related to vitamin D metabolism, particularly in the vitamin D receptor and binding protein and the metabolizing enzyme 1-α-hydroxylase, have emerged as potential contributors to these divergent results. Read More

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http://dx.doi.org/10.1111/obr.12793DOI Listing
February 2019
1 Read

Airway infection with Nontypeable Haemophilus influenzae is more rapidly eradicated in vitamin D deficient mice.

J Steroid Biochem Mol Biol 2018 Nov 3. Epub 2018 Nov 3.

Laboratory of Respiratory Diseases, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium. Electronic address:

Chronic obstructive pulmonary disease (COPD), which is characterized by an excessive inflammatory response of the airways, is often complicated by exacerbations. Vitamin D deficiency has been associated with an increased risk for COPD and may predispose COPD patients to a higher exacerbation rate, particularly during smoking. In the current study, we investigated the effect of vitamin D deficiency and cigarette smoke (CS)-exposure on lung inflammation and bacterial clearance after an acute infection with Nontypeable Haemophilus influenzae (NTHi). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09600760183045
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http://dx.doi.org/10.1016/j.jsbmb.2018.10.021DOI Listing
November 2018
8 Reads

Association of Vitamin D Deficiency with Increased Pulse Wave Velocity and Augmentation Index in Children With Chronic Kidney Disease.

Iran J Kidney Dis 2018 Oct;12(5):275-280

Ege University Faculty of Medicine, Department of Pediatric Nephrology, ?zmir, Turkey.

Introduction: It is known that in children with chronic kidney disease (CKD), cardiovascular damage starts in the form of arterial stiffness. There are risk factors other than the traditional ones such as arterial stiffness hypertension, obesity, hypercholesterolemia, and insulin resistance. Vitamin D deficiency is rather common in CKD, and it was introduced as a risk factor for atherosclerosis; however, its relationship with arterial stiffness is not known completely. Read More

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October 2018
8 Reads

Association between vitamin D levels and nonalcoholic fatty liver disease: potential confounding variables.

Mini Rev Med Chem 2018 Oct 25. Epub 2018 Oct 25.

Institute of Translational Pharmacology, National Research Council, Via Fosso del Cavaliere, 100 00133-Rome. Italy.

Nonalcoholic fatty liver disease (NAFLD), historically considered as the hepatic component of the metabolic syndrome, is a spectrum of fat-associated liver conditions in the absence of secondary causes that may progress to nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. Disease progression is closely associated with body weight or fatness, dyslipidemia, insulin resistance, oxidative stress, and inflammation. Recently, there has been a significant scientific interest into the relationship between vitamin D status and NAFLD. Read More

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http://dx.doi.org/10.2174/1389557518666181025153712DOI Listing
October 2018
1 Read

Vitamin D Deficiency and Immune Disorders in Combined Endocrine Pathology.

Front Endocrinol (Lausanne) 2018 9;9:600. Epub 2018 Oct 9.

Endocrinology Department, Bogomolets National Medical University, Kyiv, Ukraine.

Combined endocrine pathology is a serious healthcare problem in Ukraine. This prospective study assessed the blood levels of 25-hydroxyvitamin D [25(OH)D] and markers of immune function in response to vitamin D intervention in patients with type 1 and type 2 diabetes mellitus (T1DM and T2DM, respectively) and autoimmune thyroiditis (AIT). This study evaluated the relationship between the metabolic and immune status of DM + AIT patients with respect to their vitamin D status and changes after vitamin D supplementation. Read More

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http://dx.doi.org/10.3389/fendo.2018.00600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190873PMC
October 2018
1 Read

Treatment of Vitamin D Deficiency and Comorbidities: A Review.

Authors:
Parminder Singh

J Assoc Physicians India 2018 Jan;66(1):75-82

Professor and the Head of Department- Endocrinology, Dayanand Medical College and Hospital, Ludhiana, Punjab.

Vitamin D is essential for the maintenance of calcium and phosphorus homeostasis, skeletal growth and various other metabolic processes. The prevalence of vitamin D deficiency in India is 50-90% in various studies. Factors such as low sunlight exposure, age-related decrease in cutaneous synthesis, and low dietary intake of vitamin D contribute to the high prevalence of vitamin D inadequacy which has emerged as a highly pervasive condition. Read More

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January 2018
10 Reads

Vitamin D status and its management for achieving optimal health benefits in the elderly.

Expert Rev Endocrinol Metab 2018 Nov 14;13(6):279-293. Epub 2018 Oct 14.

a Blizard Institute , Queen Mary University London , London , UK.

Introduction: Vitamin D deficiency is common, world-wide, but vitamin D repletion throughout life, and into older age, has accepted health benefits for bone. Many mechanisms through which vitamin D also benefits soft tissues are understood, and clinical evidence of such benefits is now accumulating, especially following re-analyses of trial data, which are revealing previously missed health benefits with correction of deficiency. Areas covered: The sources of vitamin D, its activation, mechanistic effects; problems of trials of supplementation for reducing health risks, the benefits shown for mortality, cardiovascular disease, infection and cancer; the global problem of vitamin D deficiency; age-related reductions in vitamin D efficacy, and currently recommended intakes. Read More

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http://dx.doi.org/10.1080/17446651.2018.1533401DOI Listing
November 2018

Serum vitamin D level and its relation to thyroid hormone, blood sugar and lipid profiles in Iranian sedentary work staff.

Nutr Hosp 2018 Oct 5;35(5):1107-1114. Epub 2018 Oct 5.

Introduction: the sedentary lifestyle is related to the incidence of various diseases and metabolic disorders. The aim of the current study was to understand the link between serum vitamin D levels, thyroid hormones and lipid profiles among Iranian sedentary staff.

Material And Methods: in this cross-sectional study, 300 healthy subjects with normal body mass index (BMI) and age between 18 and 65 years, with sedentary lifestyles, were included. Read More

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http://dx.doi.org/10.20960/nh.1719DOI Listing
October 2018
3 Reads
1.250 Impact Factor

Mineral bone disorders in chronic kidney disease.

Nephrology (Carlton) 2018 Oct;23 Suppl 4:88-94

Department of Medicine, Fu-Jen Catholic University Hospital, College of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan.

As the GFR loss aggravates, the disturbed mineral metabolism worsens the bone microstructure and remodelling - scenario, which is known as CKD-mineral bone disease (MBD). CKD-MBD is characterized by : (i) abnormal metabolism of calcium, phosphorus, parathyroid hormone (PTH), or vitamin D; (ii) abnormalities in bone turnover, mineralization, volume linear growth or strength; (iii) soft-tissue calcifications, either vascular or extra-osseous. Uremic vascular calcification and osteoporosis are the most common complications related to CKD-MBD. Read More

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http://doi.wiley.com/10.1111/nep.13457
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http://dx.doi.org/10.1111/nep.13457DOI Listing
October 2018
9 Reads

Association of Serum Vitamin D Concentration With Clinical Symptoms and Quality of Life in Patients With Irritable Bowel Syndrome.

J Am Coll Nutr 2018 Sep 25:1-7. Epub 2018 Sep 25.

a Department of Nutrition , Nutritional Health Research Center, Lorestan University of Medical Sciences , Khorramabad , Iran.

Objective: A high prevalence of vitamin D deficiency (VDD) in gastrointestinal (GI) disorders and the role of vitamin D in the function of the gut have been shown previously. Therefore, we aimed to evaluated the VDD and the possible association of the GI symptoms severity and quality of life (QoL) score with the serum levels of vitamin D in irritable bowel syndrome (IBS).

Methods: A total of 90 patients with IBS based on Rome III criteria enrolled in the study from the tertiary referral university hospital. Read More

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http://dx.doi.org/10.1080/07315724.2018.1510349DOI Listing
September 2018
1 Read

Linking of psoriasis with osteopenia and osteoporosis: A cross-sectional study.

Indian J Dermatol Venereol Leprol 2018 Sep 17. Epub 2018 Sep 17.

General Dermatology Department, Dermatology Unit, Virgin de las Nieves University Hospital; Dermatology Department, Medicine School of the University of Granada, Granada, Spain.

Background/purpose: Psoriasis is a multisystem disease which has been related to vitamin-D deficiency through chronic inflammation. This psoriasis-related inflammatory state and vitamin-D deficiency may induce bone mineral density loss. The purpose of this study is to assess the relationship of psoriasis with bone mineral density, by comparing psoriatic patients with healthy controls and patients with osteopenia/osteoporosis. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_831_17DOI Listing
September 2018
7 Reads

Global prevalence and disease burden of vitamin D deficiency: a roadmap for action in low- and middle-income countries.

Ann N Y Acad Sci 2018 Oct 18;1430(1):44-79. Epub 2018 Sep 18.

University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Vitamin D is an essential nutrient for bone health and may influence the risks of respiratory illness, adverse pregnancy outcomes, and chronic diseases of adulthood. Because many countries have a relatively low supply of foods rich in vitamin D and inadequate exposure to natural ultraviolet B (UVB) radiation from sunlight, an important proportion of the global population is at risk of vitamin D deficiency. There is general agreement that the minimum serum/plasma 25-hydroxyvitamin D concentration (25(OH)D) that protects against vitamin D deficiency-related bone disease is approximately 30 nmol/L; therefore, this threshold is suitable to define vitamin D deficiency in population surveys. Read More

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http://dx.doi.org/10.1111/nyas.13968DOI Listing
October 2018
4.313 Impact Factor

Vitamin D Intake and Status of Children With Sickle Cell Disease in Montreal, Canada.

J Pediatr Hematol Oncol 2018 Nov;40(8):e531-e536

Department of Nutrition, Université de Montréal.

Sickle cell disease (SCD) and vitamin D deficiency share manifestations such as bone complications and bony pains. Canadian SCD children are characterized by compromised sun exposure all year long and potential dietary deficiency, which combined to SCD-causing high nutritional demands, may lead to impaired vitamin D status. The objectives of this study were to document vitamin D status and intake and assess the relationship between vitamin D status and SCD-related outcomes in Canadian children with SCD followed in a tertiary pediatric center. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001306DOI Listing
November 2018
8 Reads

Assessment of Biochemical and Densitometric Markers of Calcium-Phosphate Metabolism in the Groups of Patients with Multiple Sclerosis Selected due to the Serum Level of Vitamin D.

Biomed Res Int 2018 23;2018:9329123. Epub 2018 Aug 23.

Department of Neurology, SMDZ in Zabrze, Medical University of Silesia in Katowice, ul. 3-go Maja 13-15, 41-800 Zabrze, Poland.

Background: In addition to the widely known effect of vitamin D (vitD) on the skeleton, its role in the regulation of the immune response was also confirmed.

Aim: The assessment of biochemical and densitometric markers of calcium-phosphate metabolism in the groups of patients with relapsing-remitting multiple sclerosis (RRMS) selected due to the serum level of vitamin D.

Methods: The concentrations of biochemical markers and indices of lumbar spine bone densitometry (DXA) were determined in 82 patients divided into vitamin D deficiency (VitDd), insufficiency (VitDi), and normal vitamin D level (VitDn) subgroups. Read More

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http://dx.doi.org/10.1155/2018/9329123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126066PMC
January 2019
2 Reads

Signaling pathways and therapeutic perspectives related to environmental factors associated with multiple sclerosis.

J Neurosci Res 2018 Dec 11;96(12):1831-1846. Epub 2018 Sep 11.

Departments of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida.

Multiple sclerosis (MS) is an immune-mediated demyelinating disorder of unknown etiology. Both genetic-susceptibility and environment exposures, including vitamin D deficiency, Epstein-Barr viral and Herpesvirus (HHV-6) infections are strongly implicated in the activation of T cells and MS-pathogenesis. Despite precise knowledge of how these factors could be operating alone or in combination to facilitate and aggravate the disease progression, it is clear that prolonged induction of inflammatory molecules and recruitment of other immune cells by the activated T cells results in demyelination and axonal damage. Read More

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http://dx.doi.org/10.1002/jnr.24322DOI Listing
December 2018
1 Read
2.594 Impact Factor

Endocrine complications of celiac disease: a case report and review of the literature.

Endocr Res 2018 Sep 10:1-19. Epub 2018 Sep 10.

c Department of Medicine , University of Texas Health Science Center at San Antonio , San Antonio , TX , USA.

Purpose: The purpose of this article is to review recent literature regarding endocrine disorders related to celiac disease (CD).

Methods: We describe a case report and review existing literature on the endocrine manifestations of CD.

Results: CD is an autoimmune disorder characterized by intestinal inflammation in response to gluten. Read More

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http://dx.doi.org/10.1080/07435800.2018.1509868DOI Listing
September 2018
5 Reads

Vitamin D deficiency and infection risk in kidney transplant recipients: A single-center cohort study.

Transpl Infect Dis 2018 Dec 21;20(6):e12988. Epub 2018 Sep 21.

Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), School of Medicine, Universidad Complutense, Madrid, Spain.

Background: Recent studies have reported an increased susceptibility to infection among vitamin D-deficient kidney transplant (KT) recipients, although methodological concerns remain.

Methods: Serum 25-hydroxyvitamin D (25(OH)D) levels were measured in 246 KT recipients at post-transplant months 1, 3, 6 and 12. Vitamin D status was analysed in terms of deficiency (Endocrine Society [<20 ng/mL] and Institute of Medicine [IoM, <12 ng/mL] criteria) and as a continuous variable. Read More

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http://dx.doi.org/10.1111/tid.12988DOI Listing
December 2018
5 Reads

Polymorphisms of Genes Related to Function and Metabolism of Vitamin D in Esophageal Adenocarcinoma.

J Gastrointest Cancer 2018 Sep 5. Epub 2018 Sep 5.

Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, 500 W. Thomas Road, Suite 500, Phoenix, AZ, USA.

Purpose: The vitamin D receptor (VDR) endocrine system has emerged as an endogenous pleiotropic biological cell regulator with anti-neoplastic effects on breast, colorectal, and prostatic adenocarcinomas. We studied the association of gene expression, polymorphisms of VDR, CYP27B1, and CYP24A1 genes and serum vitamin D levels as surrogate markers of disease progression in patients with acid reflux, Barrett's esophagus (BE), or esophageal adenocarcinoma (EAC).

Methods: We analyzed blood and tissue samples from patients with biopsy-confirmed BE or EAC for vitamin D levels, gene expressions, and polymorphisms in VDR (FokI [F/f], BsmI [B/b], ApaI [A/a], and TaqI [T/t]), CYP27B1 (HinfI [H/h]), and CYP24A1 (Hpy1881 [Y/y]). Read More

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http://dx.doi.org/10.1007/s12029-018-0164-6DOI Listing
September 2018
7 Reads

Comorbid conditions in lichen planopilaris: A retrospective data analysis of 334 patients.

Int J Womens Dermatol 2018 Sep 7;4(3):180-184. Epub 2018 Jun 7.

Department of Dermatology and Dermatopathology, Cleveland Clinic Foundation, Cleveland, Ohio.

Background: Lichen planopilaris (LPP) is a rare, cicatricial, lymphocyte-mediated alopecia that is thought to have an autoimmune pathogenesis and possibly related to other autoimmune diseases. However, data are limited and studies that examine comorbid conditions are lacking.

Objectives: We sought to determine the prevalence of systemic comorbid conditions, nutritional deficiencies, psychological problems, and skin cancers in patients with LPP. Read More

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http://dx.doi.org/10.1016/j.ijwd.2018.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116820PMC
September 2018
2 Reads

Does severe vitamin D deficiency impact obstetric outcomes in pregnant women with thyroid autoimmunity?

J Matern Fetal Neonatal Med 2018 Sep 25:1-11. Epub 2018 Sep 25.

b Faculty of Medicine, Division of Biostatistics , Marmara University , Istanbul , Turkey.

Purpose: Vitamin D plays an important role in the modulation of the immune system and anti-autoimmune activities. Autoimmune thyroid diseases related to endocrine disorders are associated with poor obstetric outcomes in pregnancy. Herein, we aimed to investigate the contribution of vitamin D hypovitaminosis to poor pregnancy outcomes in pregnant women with the positive autoimmune antibody. Read More

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http://dx.doi.org/10.1080/14767058.2018.1519017DOI Listing
September 2018
1 Read

Vitamin D deficiency in patients with aggressive periodontitis.

Oral Dis 2018 Aug 31. Epub 2018 Aug 31.

Department of Endocrinology, School of Medicine, Ondokuz Mayıs University, Samsun, Turkey.

Objectives: Vitamin D deficiency is a frequent health problem worldwide, especially as fewer people spend much time in the sun. Vitamin D deficiency is linked to several infectious and inflammatory conditions, including periodontal disease. However, its role in aggressive periodontitis (AgP) has not been well studied. Read More

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http://doi.wiley.com/10.1111/odi.12968
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http://dx.doi.org/10.1111/odi.12968DOI Listing
August 2018
7 Reads

Vitamin D in acutely ill patients.

J Int Med Res 2018 Oct 29;46(10):4246-4257. Epub 2018 Aug 29.

4 Department of Rheumatology, St Paul's Hospital, Thessaloniki, Greece.

Objective To investigate 25(OH)D levels and their relationship to survival in a cohort of acutely ill patients on admission to an intensive care unit. Methods This study enrolled acutely ill patients at admission to an intensive care unit and a group of sex- and age-matched healthy control subjects. The 25(OH)D levels were measured using an enzyme immunoassay. Read More

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http://dx.doi.org/10.1177/0300060518792783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166351PMC
October 2018
7 Reads

Systemic Activation of Activin A Signaling Causes Chronic Kidney Disease-Mineral Bone Disorder.

Int J Mol Sci 2018 Aug 23;19(9). Epub 2018 Aug 23.

Department of Pediatrics, Washington University School of Medicine, 660 S. Euclid, St. Louis, MO 63110, USA.

The high cardiovascular mortality associated with chronic kidney disease (CKD) is caused in part by the CKD-mineral bone disorder (CKD-MBD) syndrome. The CKD-MBD consists of skeletal, vascular and cardiac pathology caused by metabolic derangements produced by kidney disease. The prevalence of osteopenia/osteoporosis resulting from the skeletal component of the CKD-MBD, renal osteodystrophy (ROD), in patients with CKD exceeds that of the general population and is a major public health concern. Read More

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http://dx.doi.org/10.3390/ijms19092490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163495PMC
August 2018
8 Reads

Bone disorders associated with diabetes mellitus and its treatments.

Joint Bone Spine 2018 Aug 8. Epub 2018 Aug 8.

Service de rhumatologie, CHU de Lille, 59000 Lille, France; EA4490, physiopathologie des maladies osseuses inflammatoires (PMOI), université Lille, université littoral Côte d'Opale, 59000 Lille, France.

Both type 1 and type 2 diabetes mellitus are associated with bone disorders, albeit via different mechanisms. Early studies in patients with type 1 diabetes suggested a 10-fold increase in the hip fracture risk compared to non-diabetic controls. Meta-analyses published more recently indicate a somewhat smaller risk increase, with odds ratios of 6 to 7. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1297319X183019
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http://dx.doi.org/10.1016/j.jbspin.2018.08.002DOI Listing
August 2018
3 Reads

Vitamin D status correlates with the markers of cystic fibrosis-related pulmonary disease.

Pediatr Neonatol 2018 Jul 19. Epub 2018 Jul 19.

Sher-I-Kashmir Institute of Medical Sciences Hospital, Srinagar, Jammu & Kashmir, India.

Background: The prevalence of Vitamin D deficiency remains high in cystic fibrosis despite daily supplementation. Vitamin D as an immunomodulator has been related to lower respiratory tract infections in children. The present study was undertaken to examine the association between vitamin D status and markers of cystic fibrosis-related pulmonary disease including exacerbations, bacterial colonization and pulmonary function. Read More

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http://dx.doi.org/10.1016/j.pedneo.2018.07.001DOI Listing
July 2018
9 Reads

25-Hydroxyvitamin D Status and Its Association with Sleep Duration in Chinese Schoolchildren.

Nutrients 2018 Aug 3;10(8). Epub 2018 Aug 3.

Ningbo Center for Disease Control and Prevention, Ningbo 315010, Zhejiang, China.

Objective: To examine the association between 25-Hydroxyvitamin D (25(OH)D) levels and sleep duration among Chinese adolescents.

Subjects And Methods: A school-based cross-sectional study was conducted among Chinese adolescents in 2017. Data on a total of 800 adolescents aged 8⁻14 years was used for this study. Read More

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http://dx.doi.org/10.3390/nu10081013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116160PMC
August 2018
1 Read
3.150 Impact Factor

Risk factors for nonunion of bone fracture in pediatric patients: An inception cohort study of 237,033 fractures.

Medicine (Baltimore) 2018 Aug;97(31):e11691

Department of Orthopedic Surgery, Louisiana State University Health Science Center, New Orleans.

Adult fracture nonunion risk is related to injury severity and surgical technique, yet nonunion is not fully explained by these risk factors alone; biological risk factors are also important. We test a hypothesis that risk factors associated with pediatric fracture nonunion are similar to adult nonunion risk factors.Inception cohort study in a large payer database of pediatric fracture patients (0-17 years) in the United States in calendar year 2011. Read More

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http://dx.doi.org/10.1097/MD.0000000000011691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081185PMC
August 2018
6 Reads

Vitamin D deficiency and treatment versus risk of infection in end-stage renal disease patients under dialysis: a systematic review and meta-analysis.

Nephrol Dial Transplant 2019 Jan;34(1):146-156

Global Health-Health Systems and Policy, Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.

Background: Infections are common and can be fatal in patients undergoing long-term dialysis. Recent studies have shown conflicting evidence associating infection with vitamin D status or use of vitamin D and have not been systematically reviewed in this population.

Methods: We searched PubMed, Web of Science, Cochrane Library, Embase and three Chinese databases from inception until December 2017 for interventional [non-randomized or randomized controlled trials (RCTs)], cohort and case-control studies on levels of serum 25-hydroxyvitamin D [25(OH)D] or use of vitamin D [supplemental nutritional vitamin D or vitamin D receptor activator (VDRA)] and infection (any infection, infection-required hospitalization or infection-related death or composite) in long-term dialysis patients. Read More

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http://dx.doi.org/10.1093/ndt/gfy216DOI Listing
January 2019
1 Read

Genetic Determinants of Vitamin D-Related Disorders; Focus on Vitamin D Receptor.

Curr Drug Metab 2018 ;19(12):1042-1052

Department of Physical Pharmacy and Pharmacokinetics, Faculty of Pharmacy, Poznan University of Medical Sciences, Poznan, Poland.

Background: The endocrine system of vitamin D is involved in an extensive variety of biological processes such as bone metabolism, regulation of cell proliferation and differentiation and modulation of the immune response. The active form of vitamin D, 25-hydroxyvitamin D, binds to vitamin D receptor (VDR) controlling the synthesis of many different proteins. Although numerous studies reported polymorphism in the VDR gene, the impact of the polymorphic alleles on VDR protein function remains unknown. Read More

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http://dx.doi.org/10.2174/1389200219666180723143552DOI Listing
January 2018
12 Reads

Vitamin D deficiency and risk of cardiovascular diseases: a narrative review.

Clin Hypertens 2018 22;24. Epub 2018 Jun 22.

Department of Internal Medicine, Hurley Medical Center/Michigan State University, Two Hurley Plaza, Suite 212, Flint, MI 48503 USA.

Vitamin D, a fat-soluble prohormone, has wide-ranging roles in the regulation of many physiological processes through their interactions with the vitamin D receptors (VDR). It plays a major role in bones and calcium metabolism. Vitamin D deficiency is not uncommon and it has been associated with many health-related issues, including skeletal and non-skeletal complications. Read More

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http://dx.doi.org/10.1186/s40885-018-0094-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013996PMC
June 2018
8 Reads

Conditions Associated with Essential Tremor in Veterans: A Potential Role for Chronic Stress.

Tremor Other Hyperkinet Mov (N Y) 2018 17;8:517. Epub 2018 May 17.

Knowledge Management, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA.

Background: Increased depression, hearing loss, dementia, alcoholism, and mortality in essential tremor patients remain unexplained. We investigated whether conditions associated with tremor are linked to chronic stress.

Methods: The FY2013 Veterans Affairs database was queried for 38 selected dual diagnosis combinations in 5,854,223 veterans aged 21-95 years. Read More

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http://dx.doi.org/10.7916/D8VD8FF5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026277PMC
November 2018
2 Reads

Vitamin D supplementation in patients with alcoholic liver cirrhosis: a prospective study.

Minerva Med 2018 Oct 2;109(5):352-357. Epub 2018 Jul 2.

Department of Health Sciences, Magna Græcia University, Catanzaro, Italy -

Background: The liver is involved in the metabolism of vitamin D. The prevalence of osteopenia in alcoholic liver disease (ALD) patients is 34-48%, and the prevalence of osteoporosis is 11-36%. Advanced liver disease is considered a risk factor for the development of osteoporosis. Read More

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http://dx.doi.org/10.23736/S0026-4806.18.05723-3DOI Listing
October 2018
1 Read

Vitamin D Deficiency and Its Relationship with Child-Pugh Class in Patients with Chronic Liver Disease.

J Clin Transl Hepatol 2018 Jun 1;6(2):135-140. Epub 2018 Feb 1.

Department of Medicine, Fauji Foundation Hospital, Rawalpindi, Pakistan.

Skeletal manifestation in liver diseases represents the minimally scrutinized part of the disease spectrum. Vitamin D deficiency has a central role in developing hepatic osteodystrophy in patients with chronic liver disease. This study aimed to investigate vitamin D levels and their relationship with disease advancement in these patients. Read More

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http://dx.doi.org/10.14218/JCTH.2017.00055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018313PMC
June 2018
1 Read

Vitamin D Supplementation in Elderly Black Women Does Not Prevent Bone Loss: A Randomized Controlled Trial.

J Bone Miner Res 2018 Nov 19;33(11):1916-1922. Epub 2018 Jul 19.

Bone Mineral Research Center, New York University (NYU) Winthrop Hospital, Mineola, NY, USA.

Black Americans have lower levels of serum 25(OH)D but superior bone health compared to white Americans. There is controversy over whether they should be screened for vitamin D deficiency and have higher vitamin D requirements than recommended by the Institute of Medicine (IOM). The purpose of this trial was to determine whether Vitamin D supplementation in elderly black women prevents bone loss. Read More

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http://dx.doi.org/10.1002/jbmr.3521DOI Listing
November 2018
1 Read

Vitamin D Supplementation Guidelines for General Population and Groups at Risk of Vitamin D Deficiency in Poland-Recommendations of the Polish Society of Pediatric Endocrinology and Diabetes and the Expert Panel With Participation of National Specialist Consultants and Representatives of Scientific Societies-2018 Update.

Front Endocrinol (Lausanne) 2018 31;9:246. Epub 2018 May 31.

Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland.

Introduction: Vitamin D deficiency is an important public health problem worldwide. Vitamin D deficiency confers a significant risk for both skeletal and non-skeletal disorders and a number of lifelong negative health outcomes. The objectives of this evidence-based guidelines document are to provide health care professionals in Poland, an updated recommendation for the prevention, diagnosis and treatment of vitamin D deficiency. Read More

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http://dx.doi.org/10.3389/fendo.2018.00246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990871PMC
May 2018
15 Reads

Impact of vitamin D treatment on 25 hydroxy vitamin D levels and insulin homeostasis in obese African American adolescents in a randomized trial.

J Clin Transl Endocrinol 2018 Jun 26;12:13-19. Epub 2018 Mar 26.

Div. of Pediatric Endocrinology, CPP M30, 1601, 4th Ave S, Children's Hospital of Alabama, University of Alabama at Birmingham, Birmingham, AL 35233, United States.

Background: Obesity is affecting children in epidemic proportions in the United States with nearly 25% of children being obese. Consequences of obesity including dyslipidemia, type 2 diabetes and cardiovascular disease are leading to morbidity at younger ages. Parallel to the obesity and diabetes epidemics, the prevalence of vitamin D deficiency has reached very high levels and has been associated with insulin resistance and dyslipidemia. Read More

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http://dx.doi.org/10.1016/j.jcte.2018.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992309PMC
June 2018
2 Reads

Role of Vitamin D Replacement on Health Related Quality of Life in Hospitalized Patients with "Acute Exacerbation of Chronic Obstructive Pulmonary Disease".

Iran J Pharm Res 2018 ;17(2):801-810

Department of Internal Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Burden of Chronic Obstructive Pulmonary Disease (COPD) is substantial and increasing in the world. There are controversial reports regarding vitamin D supplementation in COPD. We investigated relationship between vitamin D3 (Cholecalciferol) supplementation with Health Related Quality of Life (HRQOL) and symptom recovery in AECOPD patients with concurrent Vitamin D Deficiency (VDD). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985196PMC
January 2018
2 Reads

Vitamin D in melanoma: Controversies and potential role in combination with immune check-point inhibitors.

Cancer Treat Rev 2018 Sep 31;69:21-28. Epub 2018 May 31.

Medical Oncology Unit, Department of Biomedical Sciences and Human Oncology, University of Bari 'Aldo Moro', Italy.

The role of vitamin D in melanoma is still controversial. Although several Authors described a correlation between vitamin D deficiency and poor survival in metastatic melanoma patients, clinical trials exploring the effects of vitamin D supplementation in this clinical setting were mostly inconclusive. However, recent evidence suggests that vitamin D exerts both anti-proliferative effects on tumor cells and immune-modulating activities, that have been widely explored in auto-immune disorders. Read More

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http://dx.doi.org/10.1016/j.ctrv.2018.05.016DOI Listing
September 2018
13 Reads
7.590 Impact Factor