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    1243 results match your criteria Vitamin D Deficiency and Related Disorders

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    Vitamin D, Homocysteine, and Folate in Subcortical Vascular Dementia and Alzheimer Dementia.
    Front Aging Neurosci 2017 30;9:169. Epub 2017 May 30.
    Italian Liver Foundation, Centro Studi FegatoTrieste, Italy.
    Dementia is a worldwide health problem which affects millions of patients; Alzheimer's disease (AD) and subcortical vascular dementia (sVAD) are the two most frequent forms of its presentation. As no definite therapeutic options have been discovered, different risk factors for cognitive impairment have been searched for potential therapies. This report focuses on the possible evidence that vitamin D deficiency and hyper-homocysteinemia can be considered as two important factors for the development or the progression of neurodegenerative or vascular pathologies. Read More

    Vitamin D status in renal transplant recipients living in a low-latitude city: association with body fat, cardiovascular risk factors, estimated glomerular filtration rate and proteinuria.
    Br J Nutr 2017 May 8;117(9):1279-1290. Epub 2017 Jun 8.
    6Department of Applied Nutrition,Nutrition Institute,Rio de Janeiro State University,Rio de Janeiro 20550-900,Brazil.
    Recent evidence suggests that vitamin D deficiency is associated with CVD, impaired kidney function and proteinuria. To date, no study has evaluated these associations in renal transplant recipients (RTR) adjusting for body adiposity assessed by a 'gold standard' method. This study aimed to evaluate the vitamin D status and its association with body adiposity, CVD risk factors, estimated glomerular filtration rate (eGFR) and proteinuria in RTR, living in Rio de Janeiro, Brazil (a low-latitude city (22°54'10"S)), taking into account body adiposity evaluated by dual-energy X-ray absorptiometry (DXA). Read More

    Nutrients and Neurology.
    Continuum (Minneap Minn) 2017 Jun;23(3, Neurology of Systemic Disease):822-861
    Purpose Of Review: This article provides an update on the clinical presentation and management of neurologic disease related to key nutrient deficiencies.

    Recent Findings: Major advances have been made in understanding the pathway related to vitamin B12 absorption and distribution. It is now known that deficiencies of vitamin B12 and copper have similar neurologic manifestations. Read More

    Nutritional Vitamin D in Renal Transplant Patients: Speculations and Reality.
    Nutrients 2017 May 27;9(6). Epub 2017 May 27.
    Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano 20122, Italy.
    Reduced levels of nutritional vitamin D are commonly observed in most chronic kidney disease (CKD) patients and particularly in patients who have received a kidney transplant (KTx). In the complex clinical scenario characterizing the recipients of a renal graft, nutritional vitamin D deficiency has been put in relation not only to the changes of mineral and bone metabolism (MBM) after KTx, but also to most of the medical complications which burden KTx patients. In fact, referring to its alleged pleiotropic (non-MBM related) activities, vitamin D has been claimed to play some role in the occurrence of cardiovascular, metabolic, immunologic, neoplastic and infectious complications commonly observed in KTx recipients. Read More

    Vitamin D Deficiency and Associated Factors in Patients with Mental Disorders Treated in Routine Practice.
    J Nutr Sci Vitaminol (Tokyo) 2017 ;63(2):85-95
    Public Health Institute Kragujevac, Faculty of Medical Sciences, University of Kragujevac.
    This research aimed to investigate factors associated with vitamin D deficiency and to provide data about its prevalence in patients suffering from different psychiatric illnesses. The study had a cross-sectional design and it included 220 patients of both genders, aged from 19-81 y, with a wide range of mental disorders (F00-F89), and treated in routine ambulatory and hospital practice. The researchers collected data from three sources: medical records, a study questionnaire and biochemical analysis of patients' serum samples (concentration of vitamin D measured as 25(OH)D, calcium, phosphorus, magnesium, sodium and potassium). Read More

    Severe hypovitaminosis D in active tuberculosis patients and its predictors.
    Clin Nutr 2017 Apr 30. Epub 2017 Apr 30.
    Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.
    Background & Aims: Tuberculosis (TB) patients have a significant vitamin D deficiency (VDD) endemic, which may be closely related to the onset and progress of the disease. The comorbidity of diabetes (DM) and TB has posed an increasing challenge in recent years. However, the influence of DM on TB and the possible mechanism are still uncertain. Read More

    Vitamin D and plasma cell dyscrasias: reviewing the significance.
    Ann Hematol 2017 Aug 13;96(8):1271-1277. Epub 2017 May 13.
    VA Puget Sound Health Care System, Seattle, WA, USA.
    Monoclonal gammopathy of undetermined significance (MGUS) is a clonal plasma cell disorder and precursor disease to multiple myeloma and other related cancers. While MGUS is considered a benign disorder, with a low risk of disease progression, patients have altered bone microarchitecture and an increased risk of bone fracture. In addition, alterations in immune function are regularly found to correlate with disease activity. Read More

    Vitamin D: Correlation with biochemical and body composition changes in a southern Brazilian population and induction of cytotoxicity in mesenchymal stem cells derived from human adipose tissue.
    Biomed Pharmacother 2017 Jul 11;91:861-871. Epub 2017 May 11.
    São Paulo State University (UNESP), Graduate Programme in Cellular and Molecular Biology, Institute of Biosciences of Rio Claro (IBRC), Rio Claro, São Paulo, Brazil; São Paulo State University (UNESP), Graduate Programme in Pathology, School of Medicine of Botucatu, Botucatu, São Paulo, Brazil.
    Studies have shown that metabolic disorders, serum inflammatory markers and weight gain (obesity) are correlated with vitamin D deficiency. Therefore, the present study correlated the serum calcidiol (s25(OH)D3) levels in a sample of individuals from southern Brazil with variables related to metabolic disorders, obesity and lifestyle habits and assessed the cytotoxic effect of calcitriol on adipose tissue-derived mesenchymal stem cells (ADSCs). The results showed a 79. Read More

    Vitamin D Deficiency Associated With Cognitive Functioning in Psychotic Disorders.
    J Clin Psychiatry 2017 May 9. Epub 2017 May 9.
    Norwegian Centre for Mental Disorders Research (NORMENT), K. G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
    Background: Cognitive dysfunctions are core features of psychotic disorders with substantial impact on daily functioning. Vitamin D deficiency has been found to be related to cognitive dysfunctions, but the associations between vitamin D deficiency and cognition in persons with a psychotic disorder are largely unknown.

    Methods: This cross-sectional study included 225 patients with a DSM-IV psychotic disorder consecutively recruited from 2003 to 2014 and 159 randomly selected healthy controls, assessed by a cognitive test battery, a clinical protocol (including Structured Clinical Interview for DSM-IV Axis I Disorders and Positive and Negative Syndrome Scale), and a physical examination including vitamin D measurements. Read More

    Inverse relationship between vitamin D levels and platelet indices in Korean adults.
    Hematology 2017 May 10:1-7. Epub 2017 May 10.
    a Department of Family Medicine , Yonsei University Wonju College of Medicine , Wonju , Korea.
    Background And Aims: Vitamin D deficiency and increased platelet indices are associated with increased rate or risk of several diseases such as cardiovascular disease and metabolic syndrome, respectively. We investigated whether vitamin D deficiency is associated with increased platelet count (PC) and mean platelet volume (MPV).

    Methods And Results: The study included 3190 subjects older than 20 years. Read More

    Alzheimer's disease and other neurodegenerative diseases may be due to nutritional deficiencies secondary to unrecognized exocrine pancreatic insufficiency.
    Med Hypotheses 2017 May 15;102:89-90. Epub 2017 Mar 15.
    8300 Delmar, Apt 406, Saint Louis, MO 63124, United States. Electronic address:
    Alzheimer's disease (AD) may be related to nutritional deficiencies from exocrine pancreatic insufficiency (EPI) with mal-absorption of essential nutrients, vitamins and minerals. EPI occurs in about twenty percent of the elderly population, sometimes without obvious symptoms, a number similar to the incidence of AD. Other Neurological degenerative diseases with potential nutritional components such as Parkinson's disease, frailty of age and Multiple Sclerosis, a disease with increased activity from vitamin D deficiency, may also be related to untreated exocrine pancreatic insufficiency causing impaired absorption of essential dietary elements. Read More

    25-Vitamin D levels in chronic hepatitis C infection: association with cirrhosis and sustained virologic response.
    Ann Gastroenterol 2017 5;30(3):344-348. Epub 2017 Jan 5.
    Banner University Liver Disease Center, University of Arizona College of Medicine Phoenix.
    Background: Low serum 25-Vitamin D levels are associated with advanced fibrosis in hepatitis C infection. Vitamin D supplementation has been hypothesized to augment response rates to interferon-based therapy. To date, no investigation has evaluated vitamin D levels during direct-acting antiviral therapy. Read More

    Duodenal histopathology and laboratory deficiencies related to bone metabolism in coeliac disease.
    Eur J Gastroenterol Hepatol 2017 Apr 27. Epub 2017 Apr 27.
    Department of Gastroenterology and Hepatology, St Antonius Hospital, Nieuwegein, The Netherlands.
    Objectives: Coeliac disease (CD) is a chronic immune-mediated small intestine enteropathy precipitated by gluten in genetically predisposed individuals. Adult presentation is often atypical and malabsorption of vitamins and minerals is common, with a consequent disturbance of bone metabolism. We aim to evaluate laboratory deficiencies related to bone metabolism and the relationship between severity of histological damage and degree of bone mass loss at diagnosis of CD. Read More

    Vitamin D and Bronchial Asthma: An Overview of Data From the Past 5 Years.
    Clin Ther 2017 May 25;39(5):917-929. Epub 2017 Apr 25.
    Department of Clinical and Translational Science, Creighton University School of Medicine, Omaha, Nebraska. Electronic address:
    Purpose: Vitamin D is a potent immunomodulator capable of dampening inflammatory signals in several cell types involved in the asthmatic response. Its deficiency has been associated with increased inflammation, exacerbations, and overall poor outcomes in patients with asthma. Given the increase in the prevalence of asthma over the past few decades, there has been enormous interest in the use of vitamin D supplementation as a potential therapeutic option. Read More

    Association between vitamin D deficiency and health-related quality of life in patients with chronic kidney disease from the KNOW-CKD study.
    PLoS One 2017 27;12(4):e0174282. Epub 2017 Apr 27.
    Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
    Vitamin D deficiency is a growing health problem in both the general population and in patients with chronic kidney disease (CKD). However, the relationship between serum 25-hydroxyvitamin D levels and health-related quality of life in CKD is not well established. This study examined the association between vitamin D deficiency and quality of life in pre-dialysis CKD patients. Read More

    Serum vitamin D level is related to disease severity in pediatric alopecia areata.
    J Cosmet Dermatol 2017 Apr 26. Epub 2017 Apr 26.
    Department of Endocrinology and Metabolism, Konya Numune Hospital, Konya, Turkey.
    Background: Alopecia areata (AA) is the most common cause of inflammatory hair loss. AA is considered an autoimmune disease and occurs with various autoimmune disorders. Recent studies have revealed connection between autoimmune diseases and vitamin D deficiency. Read More

    Plasma metabolomics in adults with cystic fibrosis during a pulmonary exacerbation: A pilot randomized study of high-dose vitamin D3 administration.
    Metabolism 2017 May 11;70:31-41. Epub 2017 Feb 11.
    Division of Endocrinology, Metabolism & Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA; Center for Cystic Fibrosis and Airways Disease Research, Children's Healthcare of Atlanta, Atlanta, GA, USA; Section of Endocrinology, Atlanta Veterans Affairs Medical Center, Atlanta, GA, USA.
    Background: Cystic fibrosis (CF) is a chronic catabolic disease often requiring hospitalization for acute episodes of worsening pulmonary exacerbations. Limited data suggest that vitamin D may have beneficial clinical effects, but the impact of vitamin D on systemic metabolism in this setting is unknown.

    Objective: We used high-resolution metabolomics (HRM) to assess the impact of baseline vitamin D status and high-dose vitamin D3 administration on systemic metabolism in adults with CF with an acute pulmonary exacerbation. Read More

    Body composition and micronutrient deficiencies in patients with an acute exacerbation of chronic obstructive pulmonary disease.
    Intern Med J 2017 Apr 12. Epub 2017 Apr 12.
    Department of Respiratory and Sleep Medicine, Westmead Hospital, Westmead, NSW, Australia.
    Chronic obstructive pulmonary disease (COPD) is a multisystem disorder. Abnormal body composition (BC) and low serum micronutrient levels contribute significantly to morbidity associated with acute exacerbations of COPD (AECOPD). The BC and serum levels of selected micronutrients were recorded in prospective, consecutive patients admitted to hospital with an AECOPD in Western Sydney. Read More

    Awareness of osteoporosis among female head of household: an Iranian experience.
    Arch Osteoporos 2017 Dec 6;12(1):36. Epub 2017 Apr 6.
    Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
    More than 81% of the studied women had a poor knowledge of different aspects of osteoporosis and its complications, suggesting that more educational programs targeting women in particular are needed to help improve the osteoporosis practice in the societies and reduce the burden of the disease.

    Purpose: The family structure has changed considerably in the past decade. But, women from Iran and many countries in the region and even families with similar cultural background living in other parts of the world are still responsible for childcare as well as the lifestyle adapted by the family. Read More

    The Relationship between Vitamin D and Coronary Artery Ectasia in Subjects with a Normal C-Reactive Protein Level.
    Korean Circ J 2017 Mar 13;47(2):231-237. Epub 2017 Mar 13.
    Department of Cardiology, Antalya Education and Research Hospital, Antalya, Turkey.
    Background And Objectives: Vitamin D is generally known to be closely related to inflammation. The effects of vitamin D on coronary artery disease (CAD) are not fully explained. Nowadays, coronary artery ectasia (CAE) cases are common and are regarded as being a kind of CAD. Read More

    Do vitamin D levels affect the clinical prognoses of patients with knee osteoarthritis?
    J Back Musculoskelet Rehabil 2016 Mar 27. Epub 2016 Mar 27.
    Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Firat University, Elazig, Turkey.
    Objective: Although vitamin D deficiency has been associated with osteoporosis, as well as fractures, in elderly men and women, the role of vitamin D deficiency in the pathogenesis of osteoarthritis (OA) remains controversial. In this study, we aimed to investigate the effects of vitamin D deficiency on the functional status and disease prognosis of patients with knee osteoarthritis.

    Patients And Methods: Our study comprised 100 patients that met the American College of Rheumatology criteria for a diagnosis of knee osteoarthritis. Read More

    Nutritional standards needed for ready meals to avoid micronutrient deficiencies.
    • Authors:
    Nurs Older People 2017 Mar;29(3):11
    Micronutrient deficiencies contribute to many age-related disorders, although initial effects may be mild and easily missed. For example, B vitamin deficiency may result in mild cognitive decline, thiamine deficiency can contribute to development of type 2 diabetes and lack of vitamin D changes immune function. Read More

    Vitamin D Deficiency in Obsessive-Compulsive Disorder Patients with Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections: A Case Control Study.
    Noro Psikiyatr Ars 2016 Mar 1;53(1):33-37. Epub 2016 Mar 1.
    Department of Rheumatology Immunology, Çukurova University School of Medicine, Adana, Turkey.
    Introduction: Previous studies have indicated that vitamin D deficiency is common in psychiatric patients, particularly in those with neuropsychiatric disorders such as autism and schizophrenia. Vitamin D is an important neurosteroid hormone and immunomodulatory agent that also has bone metabolic effects. There has been an increasing interest in immune-related neuropsychiatric symptoms that are triggered by group A beta-hemolytic streptococcal infections. Read More

    [Pathophysiology of secondary hyperparathyroidism.]
    Clin Calcium 2017;27(4):515-520
    Inagi Municipal Hospital, Department of Nephrology, Japan.
    Secondary hyperparathyroidism(SHPT)is the result of a compensatory response of the calcium phosphate homeostatic mechanism. Vitamin D deficiency and chronic kidney disease, both representative pathophysiological causes of SHPT, have been related not only to skeletal disorders but also cardiovascular diseases, ADL and QOL. This relates the importance of SHPT as a pathological cause or marker of such states. Read More

    Knowledge and attitudes about vitamin D, and behaviors related to vitamin D in adults with and without coronary heart disease in Saudi Arabia.
    BMC Public Health 2017 Mar 16;17(1):266. Epub 2017 Mar 16.
    Public Health, School of Medicine and Menzies Health Institute Queensland, Griffith University, Building G01, Room 3.30, Gold Coast campus, Gold Coast, QLD, 4222, Australia.
    Background: Vitamin D deficiency is prevailing in Saudi Arabia. Recent national data indicated an inverse association between vitamin D status and coronary heart disease (CHD), which increases concerns about vitamin D deficiency as a serious public health problem. Therefore, the current study aimed to investigate whether knowledge, attitudes and behaviors related to vitamin D contribute to the prevalence of vitamin D deficiency among adults with and without CHD in Saudi Arabia. Read More

    The Strategy to Prevent and Regress the Vascular Calcification in Dialysis Patients.
    Biomed Res Int 2017 14;2017:9035193. Epub 2017 Feb 14.
    Division of Nephrology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Department of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan.
    The high prevalence of arterial calcification in end-stage renal disease (ESRD) is far beyond the explanation by common cardiovascular risk factors such as aging, diabetes, hypertension, and dyslipidemia. The finding relies on the fact that vascular and valvular calcifications are predictors of cardiovascular diseases and mortality in persons with chronic renal failure. In addition to traditional cardiovascular risk factors such as diabetes mellitus and blood pressure control, other ESRD-related risks such as phosphate retention, excess calcium, and prolonged dialysis time also contribute to the development of vascular calcification. Read More

    Seasonal variation in Internet searches for vitamin D.
    Arch Osteoporos 2017 Dec 10;12(1):28. Epub 2017 Mar 10.
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
    Internet search rates for "vitamin D" were explored using Google Trends. Search rates increased from 2004 until 2010 and thereafter displayed a seasonal pattern peaking in late winter. This knowledge could help guide the timing of public health interventions aimed at managing vitamin D deficiency. Read More

    European multicentre pilot survey to assess vitamin D status in rheumatoid arthritis patients and early development of a new Patient Reported Outcome questionnaire (D-PRO).
    Autoimmun Rev 2017 May 6;16(5):548-554. Epub 2017 Mar 6.
    Research Laboratory and Academic Division of Rheumatology, Department of Internal Medicine, University of Genova, IRCCS San Martino-Clinical, Viale Benedetto VX/6, 16132 Genova, Italy. Electronic address:
    Objective: To collect data on vitamin D (25(OH)D) serum levels in a large number of rheumatoid arthritis (RA) patients from different European countries, to investigate their relation with disease activity, disability, quality of life, and possibly to construct a new Patient Reported Outcome (PRO) questionnaire in order to self-estimate if they are at risk for vitamin D insufficiency/deficiency-related clinical implications (D-PRO).

    Methods: This was a European League Against Rheumatism (EULAR) supported cross-sectional study (project No CLI064) which involved 625 RA patients (mean age 55±11years, mean disease duration 11±9years), 276 age and sex matched healthy subjects, and rheumatologists working in academic institutions or hospital centres, as well as PARE organizations (patient representatives) from 13 European countries. Serum samples for 25(OH)D level measurement were collected during winter time and analyzed in a central laboratory using chemiluminescence immunoassay (DiaSorin). Read More

    Tuberculosis associated chronic obstructive pulmonary disease.
    Clin Respir J 2017 May 23;11(3):285-295. Epub 2017 Mar 23.
    MBBS, Indira Gandhi Medical College, Shimla, India.
    Objectives: Reviewed the epidemiology, clinical characteristics, mechanisms, and treatment of tuberculosis associated chronic obstructive pulmonary disease.

    Data Source: We searched PubMed, EMBASE, and the CINAHL from inception to June 2016. We used the following search terms: Tuberculosis, COPD, Tuberculosis associated COPD, and so forth. Read More

    Vitamin D and Cardiovascular Disease: Can Novel Measures of Vitamin D Status Improve Risk Prediction and Address the Vitamin D Racial Paradox?
    Curr Cardiovasc Risk Rep 2017 Jan 21;11(1). Epub 2017 Jan 21.
    Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
    Purpose Of Review: To provide a state-of-the-art update on some emerging measures of vitamin D status and discuss how assessment of these key vitamin D metabolites might improve prognostication of risk for cardiovascular disease (CVD) outcomes.

    Recent Findings: Vitamin D deficiency is a highly prevalent condition and relatively easy to treat with supplementation and/or modest sunlight exposure. A substantial body of experimental and epidemiological evidence suggest that vitamin D deficiency is a risk factor for CVD. Read More

    Serum 25-hydroxyvitamin D in pregnant women during preterm labor.
    Asia Pac J Clin Nutr 2017 Mar;26(2):287-290
    Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. Email:
    Background And Objectives: Pregnancy complications hypothesized to be related to vitamin D include preeclampsia, gestational diabetes, low birth weight, preterm delivery, Cesarean section and infectious disease. There have been a few studies which have demonstrated maternal serum vitamin D to be associated with preterm labor. The objective was to evaluate the serum vitamin D concentrations in Thai pregnant women with and without preterm labor and to find the prevalence of vitamin D deficiency and insufficiency in both groups. Read More

    [Study on anemia and vitamin A and vitamin D nutritional status of Chinese urban pregnant women in 2010-2012].
    Zhonghua Yu Fang Yi Xue Za Zhi 2017 Feb;51(2):125-131
    National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention; Key Laboratory of Trace Element Nutrition, National Health and Family Planning Commission, Beijing 100050, China.
    Objective: To evaluate the prevalence of anemia and the nutritional status of vitamins A and D by analyzing hemoglobin, serum retinol, and serum 25-hydroxyvitamin D levels in Chinese urban pregnant women during 2010-2012. Methods: Data were obtained from the China Nutrition and Health Survey in 2010-2012. Using multi-stage stratified sampling and population proportional stratified random sampling, 2 250 pregnant women from 34 metropolis and 41 middle-sized and small cities were included in this study. Read More

    Predictors of vitamin D deficiency in inflammatory bowel disease and health: A Mississippi perspective.
    World J Gastroenterol 2017 Jan;23(4):638-645
    Kumar Pallav, Patrick Sanchez, Nitin K Gupta, Division of Digestive Diseases, University of Mississippi Medical Center, Jackson, MS 39216, United States.
    Aim: To identify the predictors of vitamin D deficiency in patients with and without inflammatory bowel disease (IBD).

    Methods: Patients with ulcerative colitis (UC) or Crohn's disease (CD) related diagnostic codes who received medical care at University of Mississippi Medical Center between July 2012 and 2015 were identified. After thorough chart review, we identified patients with biopsy proven IBD who had also been tested for serum 25-hydroxyvitamin D [25(OH)D] concentration. Read More

    An efficient synthesis of 1α,25-dihydroxyvitamin D3 LC-biotin.
    J Steroid Biochem Mol Biol 2017 Feb 6. Epub 2017 Feb 6.
    Endotherm Life Science Molecules, 66123 Saarbrücken, Germany. Electronic address:
    In recent years the apparent impact of vitamin D deficiency on human health has gained increased awareness. Consequently, the development of appropriate assays to measure the status of medicinally most relevant vitamin D metabolites in human blood, serum or relevant tissue is continuously being improved. Particularly, assaying of 1α,25-dihydroxyvitamin D3, in turn considered as the most active metabolite, is mainly indicated in disorders leading to calcaemia or those resulting from an impaired 1α-hydroxylation of 25-hydroxyvitamin D3. Read More

    Thyroid disorders in polycystic ovary syndrome.
    Eur Rev Med Pharmacol Sci 2017 Jan;21(2):346-360
    Department of Gynaecological Endocrinology, Medical Faculty in Katowice, Medical University of Silesia, Katowice, Poland.
    Objective: Thyroid disorders, especially Hashimoto's thyroiditis (HT), are observed significantly more often in patients with polycystic ovary syndrome (PCOS) than in the general population - approximately 27% and 8%, respectively. This is extremely important in young women, because both disorders are connected with fertility problems. As HT and PCOS occur together, fertility problems may become a serious clinical issue in these patients. Read More

    Effects of Vitamin D treatment on thyroid autoimmunity.
    J Res Med Sci 2016 18;21:85. Epub 2016 Oct 18.
    Department of Endocrinology and Metabolism, Kayseri Training and Research Hospital, Kayseri, Turkey.
    Background: Vitamin D was shown to be related to autoimmune thyroid diseases (AITDs) in the previous studies. We aimed to investigate the relationship between Vitamin D and thyroid autoimmunity.

    Materials And Methods: Eighty-two patients, diagnosed with AITD by the endocrinology outpatient clinic, were included in this prospective study. Read More

    X-linked hypophosphatemia and growth.
    Rev Endocr Metab Disord 2017 Mar;18(1):107-115
    Division of Pediatrics, Department of Medicine. Faculty of Medicine, University of Oviedo, Oviedo, Asturias, Spain.
    X-Linked hypophosphatemia (XLH) is the most common form of hereditary rickets caused by loss-of function mutations in the PHEX gene. XLH is characterized by hypophosphatemia secondary to renal phosphate wasting, inappropriately low concentrations of 1,25 dihydroxyvitamin D and high circulating levels of fibroblast growth factor 23 (FGF23). Short stature and rachitic osseous lesions are characteristic phenotypic findings of XLH although the severity of these manifestations is highly variable among patients. Read More

    Cystatin C is Better than Serum Creatinine for Estimating Glomerular Filtration Rate to Detect Osteopenia in Chronic Kidney Disease Patients.
    Yonsei Med J 2017 Mar;58(2):380-387
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
    Purpose: Recent studies have reported that loss of bone mass is associated with renal function decline and increased fracture risks in chronic kidney disease (CKD) patients. The aim of this study was to investigate the best estimated glomerular filtration rate (eGFR) equation to detect osteopenia in CKD patients.

    Materials And Methods: This was a cross-sectional study, and 780 patients aged 50 years or above were classified into normal bone mass or osteopenia groups according to the -1. Read More

    Are Systematic Screening for Vitamin D Deficiency and Vitamin D Supplementation Currently Feasible for Ankylosing Spondylitis Patients?
    Int J Inflam 2017 1;2017:7840150. Epub 2017 Jan 1.
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa.
    Beyond its role in calcium and phosphorus metabolism for healthy bone mineralization, there is increasing awareness for vitamin D contribution in modulation of immune reactions. Given that ankylosing spondylitis (AS) is a chronic inflammatory disease involving excess immune/inflammatory activity and posing great therapeutic challenges, it is conceivable to claim that vitamin D treatment may be a safe and effective treatment to influence or modify the primary disease and its related comorbidities. Nevertheless, consistent body of research supporting this hypothesis is still lacking. Read More

    Vitamin D supplementation for sickle cell disease.
    Cochrane Database Syst Rev 2017 01 20;1:CD010858. Epub 2017 Jan 20.
    Comprehensive Sickle Cell Program, Aflac Cancer and Blood Disorders Service, Emory University School of Medicine, 1405 Clifton Road, NE, Atlanta, Georgia, USA, GA 30322.
    Background: Sickle cell disease is a genetic chronic haemolytic and pro-inflammatory disorder. The clinical manifestations of sickle cell disease result from the presence of mutations on the beta globin genes that generate an abnormal haemoglobin product (called haemoglobin S) within the red blood cell. Sickle cell disease can lead to many complications such as acute chest syndrome, stroke, acute and chronic bone complications (including painful vaso-occlusive crisis, osteomyelitis, osteonecrosis and osteoporosis). Read More

    The prevalence trend of metabolic syndrome and its components and risk factors in Korean adults: results from the Korean National Health and Nutrition Examination Survey 2008-2013.
    BMC Public Health 2017 Jan 13;17(1):71. Epub 2017 Jan 13.
    Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 410-769, Republic of Korea.
    Background: Abnormalities in the clinical markers of metabolic syndrome (MS) are associated with the development of cardiovascular disease, type 2 diabetes mellitus, and some cancers. MS prevalence in Korea increased between the mid-1990s and mid-2000s; however, no data on the recent trends of MS prevalence are available. Thus, we aimed to investigate the prevalence of MS, the five components of MS, and the related risk factors in Korean adults by using recent data. Read More

    [Nutritional status and influence of vitamin D among Chinese lactating women in 2013].
    Zhonghua Yu Fang Yi Xue Za Zhi 2016 Dec;50(12):1056-1060
    National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention; Key Laboratory of Trace Element Nutrition, National Health and Family Planning Commission, Beijing 100050, China.
    Objective: To analyze serum vitamin D levels in Chinese lactating women, in 2013, and to evaluate their vitamin D nutritional status and influencing factors. Methods: Data were from the Chinese National Nutrition and Health Surveillance in 2013. Using the multistage stratified cluster sampling method, serum samples from lactating women, at 0-24 months postpartum, were obtained from 55 sites in 30 provinces of China, excluding the Tibet Autonomous Region. Read More

    Vitamin D in autoimmune rheumatic diseases: A view inside gender differences.
    Pharmacol Res 2017 Mar 31;117:228-241. Epub 2016 Dec 31.
    Department of Movement, Human and Health Sciences, University of Rome Foro Italico, 00135 Rome, Italy. Electronic address:
    A large body of evidence highlights the role for vitamin D deficiency/insufficiency in rheumatic diseases, a group of different pathologies mostly of autoimmune origin. Vitamin D and vitamin D receptor agonists exquisitely modulate the immune system against over-reactivity towards tolerance; on this basis, vitamin D could be a good therapeutic candidate to control autoimmune processes in rheumatic diseases. Similarly, to other autoimmune pathologies, rheumatic diseases show a significant female bias. Read More

    Cognitive changes under memantine according to vitamin D status in Alzheimer patients: An exposed/unexposed cohort pilot study.
    J Steroid Biochem Mol Biol 2016 Dec 29. Epub 2016 Dec 29.
    Department of Neuroscience and Aging, Division of Geriatric Medicine, Angers University Hospital, University Memory Clinic, Research Center on Autonomy and Longevity, UPRES EA 4638, University of Angers, UNAM, Angers, France; Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada. Electronic address:
    Memantine is a symptomatic treatment that partially prevents cognitive decline in Alzheimer disease (AD). The neuroprotective effects of memantine and vitamin D may potentiate each other, with benefits for cognition. The objective of this exposed/unexposed pilot study was to determine the cognitive changes among AD patients using memantine according to the presence or absence of vitamin D deficiency (VDD). Read More

    Hypovitaminosis D and "small burden" uterine fibroids: Opportunity for a vitamin D supplementation.
    Medicine (Baltimore) 2016 Dec;95(52):e5698
    aWoman's Health Sciences Department, Gynecologic Section, Polytechnic University of Marche bDepartment of Clinical Sciences, Section of Biochemistry, Biology and Physics, Polytechnic University of Marche, Ancona, Italy.
    The aim of this study was to evaluate the effect of vitamin D supplementation in women with hypovitaminosis D and "small burden" uterine fibroids.This study focused on 208 women diagnosed with uterine fibroids and concomitant hypovitaminosis D, from January to December 2014. One hundred eight women of the initial study population were diagnosed with "small burden" uterine fibroids. Read More

    Vitamin D in Saudi Arabia: Prevalence,distribution and disease associations.
    J Steroid Biochem Mol Biol 2016 Dec 24. Epub 2016 Dec 24.
    Biomarkers Research Program,Biochemistry Department,College of Science,King Saud University,Riyadh 11451,Saudi Arabia; Prince Mutaib Chair for Biomarkers of Osteoporosis,Biochemistry Department,College of Science,King Saud University,Riyadh 11451,Saudi Arabia. Electronic address:
    More than 33 years have passed since the first paper highlighting vitamin D deficiency as a public health concern in Saudi Arabia was published in 1983. Despite "early" detection,it wasn't until the year 2010 where the interest in vitamin D research grew exponentially worldwide and was finally visible in Saudi clinical and academic areas. Since then,many landmark studies have been generated with regards to the physiologic functions of vitamin D,both skeletal and extra-skeletal. Read More

    Vitamin D and cardiovascular diseases: Causality.
    J Steroid Biochem Mol Biol 2016 Dec 24. Epub 2016 Dec 24.
    Professor of Medicine, Endocrinology & Nutrition, Cardio Metabolic Institute, NJ, USA. Electronic address:
    Vitamin D regulates blood pressure, cardiac functions, and endothelial and smooth muscle cell functions, thus, playing an important role in cardiovascular health. Observational studies report associations between vitamin D deficiency with hypertension and cardiovascular-related deaths. Peer-reviewed papers were examined in several research databases as per the guidelines of the Preferred Reporting Items for Systematic Reviews, using key words that address the relationship between vitamin D and cardiovascular disease. Read More

    The Association of Vitamin D Deficiency and Incident Frailty in Older Women: The Role of Cardiometabolic Diseases.
    J Am Geriatr Soc 2017 Mar 23;65(3):619-624. Epub 2016 Dec 23.
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland.
    Objectives: Evidence suggests vitamin D deficiency is associated with developing frailty. However, cardiometabolic factors are related to both conditions and may confound and/or mediate the vitamin D-frailty association. We aimed to determine the association of vitamin D concentration with incidence of frailty, and the role of cardiometabolic diseases (cardiovascular disease, diabetes, hyperlipidemia, hypertension) in this relationship. Read More

    Seasonality of tuberculosis in Israel, 2001-2011.
    Int J Tuberc Lung Dis 2016 Dec;20(12):1588-1593
    Ramla Department of Health, Ministry of Health, Ramla, School of Public Health, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Background: Several studies have suggested that the incidence of tuberculosis (TB) varies with the seasons.

    Objective: To determine the seasonality of TB in Israel and to explore possible associations with climatic variables.

    Methods: Laboratory-confirmed TB cases reported between 2001 and 2011 in individuals resident in Israel for at least 1 year before diagnosis were included in the study. Read More

    Effects of Vitamin D on Endometriosis-Related Pain: A Double-Blind Clinical Trial.
    Med Sci Monit 2016 Dec 17;22:4960-4966. Epub 2016 Dec 17.
    Department of Endoscopic Surgery, Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran.
    BACKGROUND Endometriosis is a disabling disease of reproductive-age women. Dysmenorrhea, dyspareunia, and pelvic pain are the main symptoms of endometriosis. Its etiology is not clear. Read More

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