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    1314 results match your criteria Vitamin D Deficiency and Related Disorders

    1 OF 27

    Impact of vitamin D on pregnancy-related disorders and on offspring outcome.
    J Steroid Biochem Mol Biol 2017 Nov 21. Epub 2017 Nov 21.
    Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany; Institute for Laboratory Medicine, IFLB, Berlin, Germany; Department of Basic Medicine, Medical College of Hunan Normal University, Changsha, China. Electronic address:
    Observational studies from all over the world continue to find high prevalence rates of vitamin D insufficiency and deficiency in many populations, including pregnant women. Beyond its classical function as a regulator of calcium and phosphate metabolism, vitamin D elicits numerous effects in the human body. Current evidence highlights a vital role of vitamin D in mammalian gestation. Read More

    Vitamin D and Neurological Diseases: An Endocrine View.
    Int J Mol Sci 2017 Nov 21;18(11). Epub 2017 Nov 21.
    Division of General Medicine, IRCCS Istituto Auxologico Italiano, Ospedale S. Giuseppe, Via Cadorna 90, 28824 Piancavallo VB, Italy.
    Vitamin D system comprises hormone precursors, active metabolites, carriers, enzymes, and receptors involved in genomic and non-genomic effects. In addition to classical bone-related effects, this system has also been shown to activate multiple molecular mediators and elicit many physiological functions. In vitro and in vivo studies have, in fact, increasingly focused on the "non-calcemic" actions of vitamin D, which are associated with the maintenance of glucose homeostasis, cardiovascular morbidity, autoimmunity, inflammation, and cancer. Read More

    New insights into the role of vitamin D in hepatocellular carcinoma.
    Expert Rev Gastroenterol Hepatol 2017 Nov 21:1-8. Epub 2017 Nov 21.
    a Center of Infectious Diseases , West China Hospital of Sichuan University , Chengdu , China.
    Introduction: In addition to being crucial for host immune defense, vitamin D is involved in cell proliferation, apoptosis, differentiation, inflammation, invasion and metastasis, angiogenesis and micro-RNA modulation. To date, clinical studies have demonstrated that vitamin D deficiency is common not only in patients with chronic liver diseases but also in those with hepatocellular carcinoma (HCC). Experimental studies have also demonstrated that vitamin D and its receptors are related to the occurrence of HCC and the prognoses of patients with HCC. Read More

    Recessive VARS2 mutation underlies a novel syndrome with epilepsy, mental retardation, short stature, growth hormone deficiency, and hypogonadism.
    Hum Genomics 2017 Nov 14;11(1):28. Epub 2017 Nov 14.
    Department of Genetics, King Faisal Specialist Hospital and Research Centre, MBC 03, PO Box 3354, Riyadh, 11211, Saudi Arabia.
    Background: Most mitochondrial and cytoplasmic aminoacyl-tRNA synthetases (aaRSs) are encoded by nuclear genes. Syndromic disorders resulting from mutation of aaRSs genes display significant phenotypic heterogeneity. We expand aaRSs-related phenotypes through characterization of the clinical and molecular basis of a novel autosomal-recessive syndrome manifesting severe mental retardation, ataxia, speech impairment, epilepsy, short stature, microcephaly, hypogonadism, and growth hormone deficiency. Read More

    Vitamin D supplementation for chronic liver diseases in adults.
    Cochrane Database Syst Rev 2017 11 3;11:CD011564. Epub 2017 Nov 3.
    Department of Internal Medicine, Medical Faculty, University of Nis, Zorana Djindjica 81, Nis, Serbia, 18000.
    Background: Vitamin D deficiency is often reported in people with chronic liver diseases. Therefore, improving vitamin D status could have a beneficial effect on people with chronic liver diseases.

    Objectives: To assess the beneficial and harmful effects of vitamin D supplementation in people with chronic liver diseases. Read More

    Impact of vitamin D status on statin-induced myopathy.
    J Clin Transl Endocrinol 2016 Dec 23;6:56-59. Epub 2016 Nov 23.
    The University of Mississippi, School of Pharmacy, Jackson, MS, United States.
    Introduction: There is a multitude of evidence supporting the benefit of statin use in cardiovascular disease; however, statin-induced myopathy is a major reason for statin discontinuation and non-adherence. Vitamin D deficiency has been independently associated with muscle weakness and severe myopathy, and may be a confounder for statin-induced myopathies. Since there is no consensus on a treatment course of action for statin-induced myopathy, investigation into potential confounders to elucidate the dynamics of statin-induced myopathy is warranted. Read More

    [Status of daily life activities and respective risk factors among centenarian population in Hainan province].
    Zhonghua Liu Xing Bing Xue Za Zhi 2017 Oct;38(10):1342-1346
    Institute of Geriatrics, Beijing Key Laboratory of Research on Aging and Related Disease, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
    Objective: To investigate the Activity of Daily life (ADL) among individuals aged 100 and above, in Hainan. Methods: From June 2014 to December 2016, a community-based cross-sectional study was conducted among individuals aged 100 and over in Hainan province. Data regarding basic information, ADL, prevalence of major age-related diseases was collected in this population. Read More

    The Relationship between Vitamin D and Type 2 Diabetes Is Intriguing: Glimpses from the Spect-China Study.
    Ann Nutr Metab 2017 Oct 13;71(3-4):195-202. Epub 2017 Oct 13.
    Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
    Objective: Vitamin D is a multifunctional vitamin for our body. Type 2 diabetes mellitus (T2DM) is a common metabolic disease. Whether T2DM affects the serum 25(OH)D level has not been reported. Read More

    Clinical diagnostic tools for vitamin D assessment.
    J Steroid Biochem Mol Biol 2017 Oct 6. Epub 2017 Oct 6.
    Department of Chemistry, College of Science, UAE University, Al Ain, United Arab Emirates.
    Vitamin D deficiency has been implicated in a plethora of diseases including rheumatoid arthritis, Parkinson's disease, Alzheimer's disease, and osteoporosis. Deficiency of this vitamin is a global epidemic affecting both developing and developed nations. Within a clinical context, the qualitative and quantitative analysis of vitamin D is therefore vital. Read More

    GLUCOCORTICOID-INDUCED BONE DISEASE: MECHANISMS AND IMPORTANCE IN PEDIATRIC PRACTICE.
    Rev Paul Pediatr 2017 Apr-Jun;35(2):207-215. Epub 2017 May 29.
    Universidade Federal de Pernambuco (UFPE), Recife, PE, Brasil.
    Objective: To describe mechanisms by which glucocorticoids cause osteoporosis, with fracture risk, combining this learning with a possible professional behavior change.

    Data Sources: A systematic search on SciELO, PubMed, Scopus, and Medline databases was carried out for consensus, review articles, including systematic reviews and meta-analysis, which were published in English, between 2000 and 2016. Keywords used on the search were the following: glucocorticoids, fractures, osteoporosis, bone health, vitamin D, children, and adolescents. Read More

    Intermediate and low abundant protein analysis of vitamin D deficient obese and non-obese subjects by MALDI-profiling.
    Sci Rep 2017 Oct 3;7(1):12633. Epub 2017 Oct 3.
    Department of Biomedical Sciences for Health, University of Milan, Segrate (Milan), Italy.
    Obesity is a pathological condition caused by genetic and environmental factors, including vitamin D deficiency, which increases the risk of developing cardiovascular disorders and diabetes. This case-control study was designed to verify whether serum profiles could be identified differentiating obese and non-obese Saudis characterized by vitamin D deficiency and pathological levels of triglycerides, high-density lipoprotein cholesterol and high total cholesterol levels. The serum protein profiles of 64 vitamin D deficient (serum 25(OH)D < 50nmol/L) individuals with metabolic syndrome and with (n = 31; BMI ≥ 30) or without (n = 33; BMI < 30) obesity were analyzed by a quantitative label-free mass spectrometry approach (MALDI-profiling), combined with different serum immunodepletion strategies (Human7 and Human14 immuno-chromatographies), to analyze the intermediate- and low-abundant protein components. Read More

    A case of osteomalacia due to deranged mineral balance caused by saccharated ferric oxide and short-bowel syndrome: A case report.
    Medicine (Baltimore) 2017 Sep;96(39):e8147
    aDepartment of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University bDivision of Laboratory and Transfusion Medicine, Hokkaido University Hospital, Sapporo, Japan.
    Rationale: Saccharated ferric oxide has been shown to lead to elevation of fibroblast growth factor 23, hypophosphatemia, and, consequently, osteomalacia. Moreover, mineral imbalance is often observed in patients with short-bowel syndrome to some degree.

    Patient Concerns: A 62-year-old woman with short-bowel syndrome related with multiple resections of small intestines due to Crohn disease received regular intravenous administration of saccharated ferric oxide. Read More

    Vitamin D deficiency accelerates ageing and age-related diseases: a novel hypothesis.
    J Physiol 2017 Nov 31;595(22):6825-6836. Epub 2017 Oct 31.
    The Babraham Institute, Cambridge, CB22 3AT, UK.
    Ageing can occur at different rates, but what controls this variable rate is unknown. Here I have developed a hypothesis that vitamin D may act to control the rate of ageing. The basis of this hypothesis emerged from studyng the various cellular processes that control ageing. Read More

    Comparison of 25-hidroksi Vitamin D serum concentrations in patients with psoriasis and psoriatic arthritis.
    J Back Musculoskelet Rehabil 2017 Sep 8. Epub 2017 Sep 8.
    Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Sakarya University Medical Faculty, Sakarya, Turkey.
    Background And Object: Rheumatoid arthritis (RA), insulin-dependent diabetes mellitus (IDDM), inflammatory bowel disease, systemic lupus erythematosus (SLE) and multiple sclerosis (MS) are some of the autoimmune diseases related to the decreases in Vitamin D levels. The same immunological properties as psoriasis, such as Th1/Th2 dysregulation, are seen in all of them. This study aims to compare 25-hidroksi Vitamin D (25-OHD) serum concentrations in patients with psoriasis and psoriatic arthritis. Read More

    Relationship of insulin resistance to vitamin d status in children with nondiabetic chronic kidney disease.
    Saudi J Kidney Dis Transpl 2017 Sep-Oct;28(5):1078-1084
    Department of Pediatric Nephrology, Ege University Medical Faculty, Izmir, Turkey.
    Insulin Resistance is common in patients with mild-to-moderate stage chronic kidney disease (CKD), even when the glomerular filtration rate is within the normal range. This study aimed to investigate the association of IR and 25-hydroxyvitamin D levels. In this study, we evaluated the frequency of IR in predialysis patients and the association with 25-hydroxyvitamin (OH)D levels. Read More

    Celiac disease-related osteopathy among Saudi celiac patients: Are we adherent to recommendations?
    Saudi J Gastroenterol 2017 Sep-Oct;23(5):291-295
    Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
    Background/aims: There are no reports from Saudi Arabia documenting the picture of osteopathy in celiac disease (CD) and the adherence of physicians to the guidelines and recommendations to screen for bone disease. We conducted this study to document the prevalence of CD-related osteopathy and the Saudi physicians' adherence to the screening recommendations.

    Patients And Methods: We identified the biopsy proven CD cases diagnosed between 2003 and 2012. Read More

    Vitamin D Is Associated with Severity and Mortality of Non-alcoholic Fatty Liver Disease: A US Population-based Study.
    J Clin Transl Hepatol 2017 Sep 7;5(3):185-192. Epub 2017 Jul 7.
    Division of Gastroenterology and Hepatology, Rutgers New Jersey Medical School, Newark, NJ, USA.
    Background and Aims: There has been increasing evidence that vitamin D deficiency may increase the risk of metabolic syndrome. Since metabolic syndrome is a major risk factor for non-alcoholic fatty liver disease (NAFLD), we aimed to investigate the association between vitamin D and the severity and mortality of NAFLD. Methods: Data was obtained from the United States Third National Health and Nutrition Examination Survey conducted in 1988-1994, with follow-up mortality data through 2011. Read More

    Adult vitamin D deficiency exacerbates impairments caused by social stress in BALB/c and C57BL/6 mice.
    Psychoneuroendocrinology 2017 Dec 6;86:53-63. Epub 2017 Sep 6.
    Queensland Brain Institute, The University of Queensland, St Lucia, QLD, Australia; Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Richlands, QLD, Australia. Electronic address:
    Vitamin D deficiency is prevalent in adults throughout the world. Epidemiological studies have shown significant associations between vitamin D deficiency and an increased risk of various neuropsychiatric and neurodegenerative disorders, such as schizophrenia, depression, Alzheimer's disease and cognitive impairment. However, studies based on observational epidemiology cannot address questions of causality; they cannot determine if vitamin D deficiency is a causal factor leading to the adverse health outcome. Read More

    Vitamin D Nutritional Status and its Related Factors for Chinese Children and Adolescents in 2010-2012.
    Nutrients 2017 Sep 15;9(9). Epub 2017 Sep 15.
    Key Laboratory of Trace Element Nutrition of National Health and Family Planning Commission, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
    Vitamin D plays a critical role in calcium and phosphate metabolism and helps maintain skeletal integrity in childhood, yet vitamin D status in Chinese children and adolescents is not well documented. The aim of this study was to assess the vitamin D status and analyze the risk factors for vitamin D deficiency in Chinese children and adolescents aged 6-17 years. Serum 25 hydroxyvitamin D (25(OH)D) was measured with a radioimmunoassay kit in 15,000 children and adolescent participants in the Chinese national nutrition and health survey (CNNHS) 2010-2012. Read More

    Digestive system in psoriasis: an update.
    Arch Dermatol Res 2017 Nov 13;309(9):679-693. Epub 2017 Sep 13.
    Dermatologikum Hamburg, Hamburg, Germany.
    Psoriasis is a chronic inflammatory immune-mediated disorder associated and often coexisting with many other immune-related clinical conditions including those affecting the gastrointestinal tract. Data obtained from the reviewed literature suggest an association between psoriasis and pathologies of the oral cavity, both psoriasis-specific lesions, as well as non-specific, such as geographic tongue or fissured tongue. These findings show the importance of thorough examination of oral mucosa in psoriatic patients. Read More

    Disorders of mechanisms of calcium metabolism control as potential risk factors of prostate cancer.
    Curr Med Chem 2017 Sep 12. Epub 2017 Sep 12.
    Department of Bromatology, Medical University of Warsaw, Poland, Banacha 1, 02-097 Warsaw. Poland.
    Prostate cancer significantly affects the overall morbidity and mortality of malignant tumours in highly developed countries. Important risk factors include family predisposition and regional, racial and dietary determinants. The scientific literature contains a great deal of data on the role of calcium and dairy products in general in the process of neoplastic transformation of the prostate. Read More

    The relationship between 25-hydroxyvitamin D concentration and liver enzymes in overweight or obese adults: Cross-sectional and interventional outcomes.
    J Steroid Biochem Mol Biol 2017 Sep 9. Epub 2017 Sep 9.
    Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3168, Australia; Diabetes and Vascular Medicine Unit, Monash Health, Melbourne, VIC 3168, Australia. Electronic address:
    Vitamin D deficiency is prevalent in individuals with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis. However, there is limited and inconsistent data on the effect of vitamin D supplementation on liver function. Hepatic enzymes have been used as surrogate markers for NAFLD and have been associated with metabolic syndrome. Read More

    Independent and Synergistic Associations of Biomarkers of Vitamin D Status With Risk of Coronary Heart Disease.
    Arterioscler Thromb Vasc Biol 2017 Nov 7;37(11):2204-2212. Epub 2017 Sep 7.
    From the Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA (L.Q., Y.H., T.W., D.S.); Department of Epidemiology (L.Q., W.M., E.B.R., F.B.H., E.G., J.E.M.) and Department of Nutrition (L.Q., Y.Z., E.B.R., F.B.H., E.G.), Harvard T.H. Chan School of Public Health, Boston, MA; and Channing Division of Network Medicine (L.Q., E.B.R., F.B.H., E.G., J.E.M.) and Division of Preventive Medicine (C.M.A., K.M.R., J.E.M.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
    Objective: To comprehensively evaluate the independent associations and potential interactions of vitamin D-related biomarkers including total and bioavailable 25-hydroxyvitamin D (25OHD), VDBP (vitamin D binding protein), and parathyroid hormone (PTH) with risk of coronary heart disease (CHD).

    Approach And Results: We prospectively identified incident cases of nonfatal myocardial infarction and fatal CHD among women in the Nurses' Health Study during 20 years of follow-up (1990-2010). Using risk-set sampling, 1 to 2 matched controls were selected for each case. Read More

    Vitamin D prenatal programming of childhood metabolomics profiles at age 3 y.
    Am J Clin Nutr 2017 Oct 23;106(4):1092-1099. Epub 2017 Aug 23.
    Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; and
    Background: Vitamin D deficiency is implicated in a range of common complex diseases that may be prevented by gestational vitamin D repletion. Understanding the metabolic mechanisms related to in utero vitamin D exposure may therefore shed light on complex disease susceptibility.Objective: The goal was to analyze the programming role of in utero vitamin D exposure on children's metabolomics profiles. Read More

    Role of vitamin D in cystic fibrosis and non-cystic fibrosis bronchiectasis.
    World J Clin Pediatr 2017 Aug 8;6(3):132-142. Epub 2017 Aug 8.
    Maria Moustaki, Ioanna Loukou, Cystic Fibrosis Unit, "Aghia Sophia" Children's Hospital, 11527 Athens, Greece.
    Bronchiectasis is usually classified as cystic fibrosis (CF) related or CF unrelated (non-CF); the latter is not considered an orphan disease any more, even in developed countries. Irrespective of the underlying etiology, bronchiectasis is the result of interaction between host, pathogens, and environment. Vitamin D is known to be involved in a wide spectrum of significant immunomodulatory effects such as down-regulation of pro-inflammatory cytokines and chemokines. Read More

    Osteoporosis in patients with erythropoietic protoporphyria.
    Br J Dermatol 2017 Aug 17. Epub 2017 Aug 17.
    Department of Internal Medicine, Porphyria Centre, Centre for Lysosomal and Metabolic Diseases, Erasmus MC, PO Box 2040, 3000, CA Rotterdam, the Netherlands.
    Background: Erythropoietic protoporphyria (EPP) is a rare metabolic disease with painful photosensitivity due to protoporphyrin IX accumulation.

    Objectives: To evaluate bone mineral density (BMD) and known osteoporosis risk factors in patients with EPP.

    Methods: Patients with EPP attending the Erasmus MC outpatient clinic who had undergone BMD measurements were included. Read More

    Vitamin D deficiency is a risk factor for infections in patients affected by HCV-related liver cirrhosis.
    Int J Infect Dis 2017 Oct 10;63:23-29. Epub 2017 Aug 10.
    Department of Clinical Medicine and Surgery, Section of Infectious Diseases, University of Naples "Federico II", Italy.
    Objectives: To evaluate the prevalence of vitamin D deficiency and its impact on infections in HCV-related liver cirrhosis.

    Methods: We enrolled 291 patients affected by HCV-related liver cirrhosis. Serum vitamin D levels were dosed at enrolment. Read More

    Vitamin D and symptoms of depression in overweight or obese adults: A cross-sectional study and randomized placebo-controlled trial.
    J Steroid Biochem Mol Biol 2017 Aug 10. Epub 2017 Aug 10.
    Monash Centre for Health Research and Implementation (MCHRI), School of Public Health and Preventive Medicine, Monash University, 43-51 Kanooka Grove, Clayton, Melbourne, VIC 3168, Australia. Electronic address:
    Recent evidence suggests that vitamin D deficiency may contribute to increased risk of depression. However, previous studies are limited by variability in participant characteristics including vitamin D deficiency status and presence of existing diseases, use of low doses of vitamin D supplementation for short durations, and use of co-interventions or psychotropic drugs. We examined whether 25-hydroxyvitamin D (25(OH)D) concentrations were associated with symptoms of depression, as well as whether vitamin D supplementation reduced symptoms of depression in overweight or obese and vitamin D-deficient, but otherwise healthy adults. Read More

    Vitamin D in the Spectrum of Prediabetes and Cardiovascular Autonomic Dysfunction.
    J Nutr 2017 Sep 2;147(9):1607-1615. Epub 2017 Aug 2.
    Department of Diabetology, Clinical Center of Endocrinology, Medical University, Sofia, Sofia, Bulgaria.
    Vitamin D is a fat-soluble secosteroid hormone with pleiotropic effects. 1,25-Dihydroxyvitamin D coordinates the biosynthesis of neurotransmitters in the central nervous system, which regulate cardiovascular autonomic function and may explain its putative role in the development of cardiovascular autonomic neuropathy (CAN). CAN is an independent risk factor for mortality in patients with diabetes and prediabetes and is associated with an increased risk of developing type 2 diabetes and cardiovascular disease. Read More

    A Systematic Review and Meta-Analysis of The Effect of Low Vitamin D on Cognition.
    J Am Geriatr Soc 2017 Oct 31;65(10):2161-2168. Epub 2017 Jul 31.
    Institute for Health and Ageing, Australian Catholic University, Melbourne, Victoria, Australia.
    Background/objective: With an aging population and no cure for dementia on the horizon, risk factor modification prior to disease onset is an urgent health priority. Therefore, this review examined the effect of low vitamin D status or vitamin D supplementation on cognition in midlife and older adults without a diagnosis of dementia.

    Design: Systematic review and random effect meta-analysis. Read More

    Study of chronic kidney disease-mineral bone disorders in newly detected advanced renal failure patients: A Hospital-based cross-sectional study.
    Saudi J Kidney Dis Transpl 2017 Jul-Aug;28(4):874-885
    Department of Nephrology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
    We aim to evaluate the disturbances in mineral metabolism, abnormalities in bone mineral density (BMD), and extraskeletal calcification in newly detected, untreated predialysis stage 4 and 5 chronic kidney disease (CKD) patients at a tertiary care hospital in North India. This is cross-sectional observational study. A total of 95 (68 males, 27 females) newly detected patients underwent clinical evaluation, biochemical assessment [serum calcium, phosphorus, alkaline phosphatase (ALP), albumin, creatinine, intact parathyroid hormone (iPTH), 25- hydroxyvitamin D (25(OH)D)], BMD measurement (at spine, hip, and forearm) by dual-energy X-ray absorptiometry (DXA), lateral abdominal radiograph [for abdominal aortic calcification (AAC)], skeletal survey (to look for any abnormality including fractures), and echocardiography [for any cardiac valvular calcification (CVC)]. Read More

    Renal osteodystrophy in the obesity era: Is metabolic syndrome relevant?
    PLoS One 2017 18;12(7):e0180387. Epub 2017 Jul 18.
    Nephrology, Department of Internal Medicine, Faculdade de Medicina Botucatu Univ. Estadual Paulista-UNESP. Botucatu, Brazil.
    Background: Observational studies have shown a beneficial effect of obesity on bone health; however, most of those studies were not based on bone biopsies. Metabolic syndrome (MetS) could have an effect on bone remodeling. However, there are no data on the effects of MetS in the presence of renal osteodystrophy. Read More

    Genetic variants underlying vitamin D metabolism and VDR-TGFβ-1-SMAD3 interaction may impact on HCV progression: a study based on dbGaP data from the HALT-C study.
    J Hum Genet 2017 Nov 13;62(11):969-977. Epub 2017 Jul 13.
    Graduate Program in Gastroenterology and Hepatology Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
    Vitamin D deficiency is prevalent in liver disease and vitamin D has been shown to decrease hepatic fibrosis through an anti-TGFβ-1/SMAD3 effect mediated by the vitamin D receptor. Thus, we hypothesized that genetic variants involved in vitamin D metabolism and/or VDR/TGFβ-1/SMAD3 interaction could impact on the progression of chronic HCV. We obtained or imputed genotypes for 40 single nucleotide polymorphisms (SNPs) located in genes implicated in vitamin D metabolism from the HALT-C cohort via dbGaP. Read More

    Obstructive sleep apnea and objective short sleep duration are independently associated with the risk of serum vitamin D deficiency.
    PLoS One 2017 7;12(7):e0180901. Epub 2017 Jul 7.
    Department of Psychobiology, Universidade Federal de Sao Paulo, São Paulo, São Paulo, Brazil.
    Background: Studies demonstrate an association between vitamin D (25(OH)D) deficiency and sleep disturbances, such as obstructive sleep apnea (OSA) and short sleep duration. However, to date, no studies have concurrently and objectively evaluated the effect of these factors on 25(OH)D.

    Objectives: To evaluate whether OSA and objective short sleep duration are independently associated with reduced 25(OH)D in an adult population sample. Read More

    Therapeutic impact of dietary vitamin D supplementation for preventing right ventricular remodeling and improving survival in pulmonary hypertension.
    PLoS One 2017 7;12(7):e0180615. Epub 2017 Jul 7.
    Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.
    Background: Pulmonary hypertension (PH), caused by elevated pulmonary vascular resistance, leads to right heart failure and ultimately death. Vitamin D deficiency can predispose individuals to hypertension and left ventricular dysfunction; however, it remains unknown how serum vitamin D level is related to PH and right ventricular (RV) dysfunction.

    Methods: Serum 25-hydroxyvitamin D [25(OH)D] levels were assessed in PH patients for an association with disease severity. Read More

    Maternal and neonatal vitamin D status, genotype and childhood celiac disease.
    PLoS One 2017 7;12(7):e0179080. Epub 2017 Jul 7.
    Norwegian Institute of Public Health, Oslo, Norway.
    Background: Low concentration of 25-hydroxyvitamin D during pregnancy may be associated with offspring autoimmune disorders. Little is known about environmental triggers except gluten for celiac disease, a common immune-mediated disorder where seasonality of birth has been reported as a risk factor. We therefore aimed to test whether low maternal and neonatal 25-hydroxyvitamin D predicted higher risk of childhood celiac disease. Read More

    Early arterial calcification does not correlate with bone loss in pseudoxanthoma elasticum.
    Bone 2017 Oct 27;103:88-92. Epub 2017 Jun 27.
    PXE Health and Research Center, University Hospital of Angers, Angers, France; MitoVasc, UMR CNRS 6015 - Inserm 1083, School of Medicine, UBL University, Angers, France; Laboratory of Physiology and Molecular Medicine - LP2M, and University Hospital of Nice, Nice, France. Electronic address:
    Background And Aims: Pseudoxanthoma elasticum (PXE; OMIM 264800, prevalence 1/25,000 to 1/50,000) is an autosomal recessive multisystem disease due to deficiency in ABCC6, an ATP-binding cassette, sub-family C transporter. The PXE phenotype is mainly characterized by progressive ectopic calcification of connective tissues (namely skin, retinal Bruch's membrane and peripheral arteries) but the impact of PXE on bone structure is currently unknown. The present study sought to investigate bone mineralization and its potential link with vascular calcification in a large cohort of PXE patients with inherited mutations of the ABCC6 gene. Read More

    Evaluation of Vitamin D Status in Rheumatoid Arthritis and Its Association with Disease Activity across 15 Countries: "The COMORA Study".
    Int J Rheumatol 2017 1;2017:5491676. Epub 2017 Jun 1.
    Department of Rheumatology, Hôpital Cochin, Paris Descartes University, Assistance Publique-Hôpitaux de Paris, EULAR Center of Excellence, INSERM (U1153): Clinical Epidemiology and Biostatistics, PRES Sorbonne Paris-Cité, Paris, France.
    The aims of this study are to evaluate vitamin D status in 1413 RA patients of COMORA study from 15 countries and to analyze relationship between patients' RA characteristics and low levels of vitamin D. All demographic, clinical, and biological data and RA comorbidities were completed. The results showed that the average of vitamin D serum dosage was 27. Read More

    Vitamin D, Homocysteine, and Folate in Subcortical Vascular Dementia and Alzheimer Dementia.
    Front Aging Neurosci 2017 30;9:169. Epub 2017 May 30.
    Italian Liver Foundation, Centro Studi FegatoTrieste, Italy.
    Dementia is a worldwide health problem which affects millions of patients; Alzheimer's disease (AD) and subcortical vascular dementia (sVAD) are the two most frequent forms of its presentation. As no definite therapeutic options have been discovered, different risk factors for cognitive impairment have been searched for potential therapies. This report focuses on the possible evidence that vitamin D deficiency and hyper-homocysteinemia can be considered as two important factors for the development or the progression of neurodegenerative or vascular pathologies. Read More

    Vitamin D status in renal transplant recipients living in a low-latitude city: association with body fat, cardiovascular risk factors, estimated glomerular filtration rate and proteinuria.
    Br J Nutr 2017 May 8;117(9):1279-1290. Epub 2017 Jun 8.
    6Department of Applied Nutrition,Nutrition Institute,Rio de Janeiro State University,Rio de Janeiro 20550-900,Brazil.
    Recent evidence suggests that vitamin D deficiency is associated with CVD, impaired kidney function and proteinuria. To date, no study has evaluated these associations in renal transplant recipients (RTR) adjusting for body adiposity assessed by a 'gold standard' method. This study aimed to evaluate the vitamin D status and its association with body adiposity, CVD risk factors, estimated glomerular filtration rate (eGFR) and proteinuria in RTR, living in Rio de Janeiro, Brazil (a low-latitude city (22°54'10"S)), taking into account body adiposity evaluated by dual-energy X-ray absorptiometry (DXA). Read More

    [Maxillary, buccal and dental expressions of hyperparathyroidisms].
    Presse Med 2017 Sep 2;46(9):845-852. Epub 2017 Jun 2.
    CHU de Lille, Lille, France.
    States of chronic parathyroid hypersecretion, related to a primitive parathyroid abnormality (adenoma, hyperplasia), or to a cause of chronic calcipenia (renal failure, vitamin D deficiency…) have a major impact on bone remodeling, alveolodental structures. Thinning of the lamina dura, maxillary or mandibular brown tumors, giant cell epulis are the most emblematic signs of the primary hyperparathyroidism. Other expressions are related to genetic factors such as fibrous tumors of the jaw in conjunction with mutations in the gene coding for parafibromin. Read More

    Nutrients and Neurology.
    Continuum (Minneap Minn) 2017 Jun;23(3, Neurology of Systemic Disease):822-861
    Purpose Of Review: This article provides an update on the clinical presentation and management of neurologic disease related to key nutrient deficiencies.

    Recent Findings: Major advances have been made in understanding the pathway related to vitamin B12 absorption and distribution. It is now known that deficiencies of vitamin B12 and copper have similar neurologic manifestations. Read More

    Nutritional Vitamin D in Renal Transplant Patients: Speculations and Reality.
    Nutrients 2017 May 27;9(6). Epub 2017 May 27.
    Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano 20122, Italy.
    Reduced levels of nutritional vitamin D are commonly observed in most chronic kidney disease (CKD) patients and particularly in patients who have received a kidney transplant (KTx). In the complex clinical scenario characterizing the recipients of a renal graft, nutritional vitamin D deficiency has been put in relation not only to the changes of mineral and bone metabolism (MBM) after KTx, but also to most of the medical complications which burden KTx patients. In fact, referring to its alleged pleiotropic (non-MBM related) activities, vitamin D has been claimed to play some role in the occurrence of cardiovascular, metabolic, immunologic, neoplastic and infectious complications commonly observed in KTx recipients. Read More

    Vitamin D Deficiency and Associated Factors in Patients with Mental Disorders Treated in Routine Practice.
    J Nutr Sci Vitaminol (Tokyo) 2017 ;63(2):85-95
    Public Health Institute Kragujevac, Faculty of Medical Sciences, University of Kragujevac.
    This research aimed to investigate factors associated with vitamin D deficiency and to provide data about its prevalence in patients suffering from different psychiatric illnesses. The study had a cross-sectional design and it included 220 patients of both genders, aged from 19-81 y, with a wide range of mental disorders (F00-F89), and treated in routine ambulatory and hospital practice. The researchers collected data from three sources: medical records, a study questionnaire and biochemical analysis of patients' serum samples (concentration of vitamin D measured as 25(OH)D, calcium, phosphorus, magnesium, sodium and potassium). Read More

    Severe hypovitaminosis D in active tuberculosis patients and its predictors.
    Clin Nutr 2017 Apr 30. Epub 2017 Apr 30.
    Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.
    Background & Aims: Tuberculosis (TB) patients have a significant vitamin D deficiency (VDD) endemic, which may be closely related to the onset and progress of the disease. The comorbidity of diabetes (DM) and TB has posed an increasing challenge in recent years. However, the influence of DM on TB and the possible mechanism are still uncertain. Read More

    Vitamin D and plasma cell dyscrasias: reviewing the significance.
    Ann Hematol 2017 Aug 13;96(8):1271-1277. Epub 2017 May 13.
    VA Puget Sound Health Care System, Seattle, WA, USA.
    Monoclonal gammopathy of undetermined significance (MGUS) is a clonal plasma cell disorder and precursor disease to multiple myeloma and other related cancers. While MGUS is considered a benign disorder, with a low risk of disease progression, patients have altered bone microarchitecture and an increased risk of bone fracture. In addition, alterations in immune function are regularly found to correlate with disease activity. Read More

    Vitamin D: Correlation with biochemical and body composition changes in a southern Brazilian population and induction of cytotoxicity in mesenchymal stem cells derived from human adipose tissue.
    Biomed Pharmacother 2017 Jul 11;91:861-871. Epub 2017 May 11.
    São Paulo State University (UNESP), Graduate Programme in Cellular and Molecular Biology, Institute of Biosciences of Rio Claro (IBRC), Rio Claro, São Paulo, Brazil; São Paulo State University (UNESP), Graduate Programme in Pathology, School of Medicine of Botucatu, Botucatu, São Paulo, Brazil.
    Studies have shown that metabolic disorders, serum inflammatory markers and weight gain (obesity) are correlated with vitamin D deficiency. Therefore, the present study correlated the serum calcidiol (s25(OH)D3) levels in a sample of individuals from southern Brazil with variables related to metabolic disorders, obesity and lifestyle habits and assessed the cytotoxic effect of calcitriol on adipose tissue-derived mesenchymal stem cells (ADSCs). The results showed a 79. Read More

    Circulating levels of sclerostin but not DKK1 associate with laboratory parameters of CKD-MBD.
    PLoS One 2017 11;12(5):e0176411. Epub 2017 May 11.
    KUL Leuven, Department of Immunology and Microbiology, Laboratory of Nephrology, Leuven, Belgium.
    Introduction: Mounting evidence indicates that a disturbed Wnt-β-catenin signaling may be involved in the pathogenesis of chronic kidney disease-mineral and bone and mineral disorder (CKD-MBD). Data on the impact of CKD on circulating levels of the Wnt antagonists sclerostin and Dickkopf related protein 1 (DKK1) and the relationship with laboratory parameters of CKD-MBD are incomplete.

    Methods: We analyzed serum sclerostin and DKK1 in 308 patients across the stages of chronic kidney disease (kDOQI stage 1-2 n = 41; CKD stage 3 n = 54; CKD stage 4-5 n = 54; hemodialysis n = 100; peritoneal dialysis n = 59) as well as in 49 healthy controls. Read More

    Vitamin D Deficiency Associated With Cognitive Functioning in Psychotic Disorders.
    J Clin Psychiatry 2017 Jul;78(7):e750-e757
    Norwegian Centre for Mental Disorders Research (NORMENT), K. G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
    Background: Cognitive dysfunctions are core features of psychotic disorders with substantial impact on daily functioning. Vitamin D deficiency has been found to be related to cognitive dysfunctions, but the associations between vitamin D deficiency and cognition in persons with a psychotic disorder are largely unknown.

    Methods: This cross-sectional study included 225 patients with a DSM-IV psychotic disorder consecutively recruited from 2003 to 2014 and 159 randomly selected healthy controls, assessed by a cognitive test battery, a clinical protocol (including Structured Clinical Interview for DSM-IV Axis I Disorders and Positive and Negative Syndrome Scale), and a physical examination including vitamin D measurements. Read More

    Inverse relationship between vitamin D levels and platelet indices in Korean adults.
    Hematology 2017 Dec 10;22(10):623-629. Epub 2017 May 10.
    a Department of Family Medicine , Yonsei University Wonju College of Medicine , Wonju , Korea.
    Background And Aims: Vitamin D deficiency and increased platelet indices are associated with increased rate or risk of several diseases such as cardiovascular disease and metabolic syndrome, respectively. We investigated whether vitamin D deficiency is associated with increased platelet count (PC) and mean platelet volume (MPV).

    Methods And Results: The study included 3190 subjects older than 20 years. Read More

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