174 results match your criteria Vitamin B-12 Associated Neurological Diseases


Review article: Clinical manifestations and outcomes of chronic nitrous oxide misuse: A systematic review.

Emerg Med Australas 2022 Jun 13. Epub 2022 Jun 13.

Department of Emergency Medicine, Northern Health, Melbourne, Victoria, Australia.

Recreational nitrous oxide (N O) use is widespread, and complications associated with its use are increasingly common. We sought to identify risk factors, clinical features and outcomes in individuals presenting with effects of chronic N O abuse to develop an approach to clinical assessment and management. A systemic literature review was completed with searches conducted across EMBASE, MEDLINE, PSYCINFO and Cochrane databases. Read More

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The dangers of recreational inhalation of nitrous oxide.

Br J Hosp Med (Lond) 2021 Dec 15;82(12):1-8. Epub 2021 Dec 15.

Department of Radiology, Royal Blackburn Hospital, Blackburn, UK.

Nitrous oxide, also known as 'laughing gas', is one of the most widely used recreational drugs among teenagers in the UK. Copious inhalation of nitrous oxide may increase intra-alveolar pressure, resulting in barotrauma secondary to alveolar rupture. Pneumomediastinum and subcutaneous emphysema are common clinical findings in nitrous oxide-associated barotrauma. Read More

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December 2021

Nitrous oxide-related neurological disorders: Clinical, laboratory, neuroimaging, and electrophysiological findings.

Brain Behav 2021 12 10;11(12):e2402. Epub 2021 Nov 10.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Background: Recreational N O abuse is an important etiology of neurological impairment in young patients, which may easily be ignored clinically. Few current studies have investigated the characteristics or the effects experienced by its users. We aimed to explore any correlation between the clinical severity and biomarkers and spinal magnetic resonance imaging (MRI) abnormalities, identify independent factors associated with spinal MRI abnormalities, and ascertain factors affecting depression/anxiety in patients with N O-related neurological disorders. Read More

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December 2021

A Brief Review on Vitamin B Deficiency Looking at Some Case Study Reports in Adults.

Int J Mol Sci 2021 Sep 7;22(18). Epub 2021 Sep 7.

CREA-Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy.

In the era of evidence-based medicine, the randomized clinical trial corresponds to the top step in the qualitative scale of the evidence available in the literature, while small series of cases or the description of individual cases occupy the last place. However, the latter represent an important part of clinical practice and have significantly influenced the evolution of medicine, contributing significantly to the advancement of scientific knowledge. Vitamin B deficiency shares several common symptoms that affect several tissues and organs with health aliments, so its diagnosis could be unobvious for the broad array of its effects and investigation methods used. Read More

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September 2021

Combined Methylmalonic Aciduria and Homocystinuria Presenting as Pulmonary Hypertension.

Indian J Pediatr 2021 Dec 12;88(12):1244-1246. Epub 2021 Sep 12.

Division of Genetics, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, 110029, India.

Combined methylmalonic aciduria and homocystinuria, cblC type, (MAHCC) is a rare autosomal recessive metabolic disorder of remethylation caused due to mutations in the MMACHC (metabolism of cobalamin associated C) gene with predominant neurological involvement. Microvascular, renal, and cardiovascular complications are also known to occur. However, the disease presenting primarily with a cardiovascular phenotype without any neurological involvement is a rare entity. Read More

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December 2021

Subclinical maculopathy and retinopathy in transcobalamin deficiency: a 10-year follow-up.

Doc Ophthalmol 2022 02 7;144(1):53-65. Epub 2021 Sep 7.

Reference Center for Inborn Errors of Metabolism, Robert Debré Hospital, AP-HP, Paris, France.

Introduction: Transcobalamin (TC) transports cobalamin (vitamin B) from plasma into cells. Its congenital deficiency is a rare autosomal recessive disorder due to mutations in the TCN2 gene. It causes intracellular cobalamin depletion with early onset in the first months of life, failure to thrive with pallor due to megaloblastic anemia. Read More

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February 2022

B vitamins and prevention of cognitive decline and incident dementia: a systematic review and meta-analysis.

Nutr Rev 2022 03;80(4):931-949

Innovation Center for Neurological Disorders, Department of Neurology, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing, China.

Context: Elevation of homocysteine (Hcy) levels is well-established as a risk factor for dementia, yet controversy exists regarding whether B-vitamin-mediated reduction of homocysteine levels can benefit cognitive function.

Objective: To investigate whether B vitamin supplementation can reduce the risk of cognitive decline and incident dementia.

Data Sources: The PubMed, EMBASE, Cochrane Library, and Web of Science were systematically searched for articles published from the inception dates to March 1, 2020. Read More

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Neurological consequences of recreational nitrous oxide abuse during SARS-CoV-2 pandemic.

J Neurol 2022 Apr 21;269(4):1921-1926. Epub 2021 Aug 21.

Service de Neurologie, APHP, Hôpital Avicenne, Hôpitaux Universitaires de Paris - Seine Saint Denis, Sorbonne Paris Nord, Bobigny, France.

Introduction: Recreational use of nitrous oxide (NO) is a growing practice in France and all around the world and is often associated with neurological complications. We report detailed clinical and paraclinical presentations of 12 patients with combined degeneration of the spinal cord and peripheral neuropathies in relation to NO consumption, possibly favored by lockdowns due to SARS-CoV-2 pandemic.

Results: With variable levels of consumption, the 12 patients presented spinal cord and/or peripheral nerve damage, with mostly motor and ataxic symptoms, motor axonal nerve damage, and medullary T2-weighted hyperintensities on MRI. Read More

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Investigating the causality of metabolites involved in one-carbon metabolism with the risk and age at onset of Parkinson's disease: A two-sample mendelian randomization study.

Neurobiol Aging 2021 12 4;108:196-199. Epub 2021 Jul 4.

Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, China; Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang 110122, China. Electronic address:

With the aging population and increasing life expectancy, Parkinson's disease (PD), a neurological disorder rapidly increasing in morbidity and mortality, is causing a huge burden on society and the economy. Several studies have suggested that one-carbon metabolites, including homocysteine, vitamin B6, vitamin B12 and folate acid, are associated with PD risk. However, the results remain inconsistent and controversial. Read More

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December 2021

Diseases associated with hypercobalaminemia in dogs in United Kingdom: A retrospective study of 47 dogs.

Can Vet J 2021 06;62(6):611-616

Highcroft Veterinary Referrals, 615 Wells Road, Whitchurch, BS14 9BE, Bristol, United Kingdom.

Cobalamin concentration is often assessed in clinical practice but little is known about the significance of hypercobalaminemia. The objective of this retrospective study was to identify the conditions associated with hypercobalaminemia in dogs and to investigate association with clinicopathological variables. Medical records of dogs having serum cobalamin measured between 2016 and 2018 were reviewed. Read More

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Late-onset methylmalonic acidemia and homocysteinemia.

Nutr Hosp 2021 Jul;38(4):871-875

Nutrition Unit. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón.

Introduction: Introduction: cobalamin C (Cbl C) deficiency is the most common defect in intracellular cobalamin metabolism, associated with methylmalonic acidemia and homocystinuria. Its late clinical presentation is heterogeneous and may lead to a diagnostic delay. Case report: we report the case of a 45-year-old man with a 20-year history of chronic kidney disease and recently diagnosed spastic paraparesis, both of unknown origin. Read More

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Elevated holo-transcobalamin in Gaucher disease type II: A case report.

Am J Med Genet A 2021 08 24;185(8):2471-2476. Epub 2021 May 24.

Postgraduate Program in Medical Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Gaucher disease (GD), one of the most common lysosomal disorders, is caused by deficiency of β-glucocerebrosidase. Based on the presence and severity of neurological complications, GD is classified into types I, II (the most severe form), and III. Abnormalities in systemic markers of vitamin B (B ) metabolism have been reported in GD type I patients, suggesting a higher prevalence of B deficiency in these patients. Read More

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Paraoxonase 1, B Vitamins Supplementation, and Mild Cognitive Impairment.

J Alzheimers Dis 2021 ;81(3):1211-1229

Department of Biochemistry and Biotechnology, Poznań University of Life Sciences, Poznań, Poland.

Background: Identification of modifiable risk factors that affect cognitive decline is important for the development of preventive and treatment strategies. Status of paraoxonase 1 (PON1), a high-density lipoprotein-associated enzyme, may play a role in the development of neurological diseases, including Alzheimer's disease.

Objective: We tested a hypothesis that PON1 status predicts cognition in individuals with mild cognitive impairment (MCI). Read More

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September 2021

[Thromboembolisms due to recreational use of nitrous oxide].

Ned Tijdschr Geneeskd 2021 04 26;165. Epub 2021 Apr 26.

OLVG, Amsterdam: Afd. Hartcentrum.

Nitrous oxide (N2O) is increasingly used as a recreational drug, and is presumed relatively safe and innocent. The risks for neurological complications are often known, however the risks of serious thromboembolic events are not. We describe three cases of acute thromboembolic events resulting in serious cardiovascular complications after N2O abuse: one case of myocardial infarction that resulted in a reduced ejection fraction, one case of peripheral arterial occlusion that led to limb amputation and one case of pulmonary embolism that resulted in hemodynamic instability requiring extracorporeal membrane oxygenation (ECMO) and surgical removal. Read More

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Combined Genome, Transcriptome and Metabolome Analysis in the Diagnosis of Childhood Cerebellar Ataxia.

Int J Mol Sci 2021 Mar 15;22(6). Epub 2021 Mar 15.

Instituto de Investigación Biosanitaria ibs.GRANADA, 18012 Granada, Spain.

Ataxia in children is a common clinical sign of numerous neurological disorders consisting of impaired coordination of voluntary muscle movement. Its most common form, cerebellar ataxia, describes a heterogeneous array of neurologic conditions with uncountable causes broadly divided as acquired or genetic. Numerous genetic disorders are associated with chronic progressive ataxia, which complicates clinical management, particularly on the diagnostic stage. Read More

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Anemia and Hematopoietic Factor Deficiencies in Patients after Endoscopic Gastrostomy: A Nine-Year and 472-Patient Study.

Nutrients 2020 Nov 26;12(12). Epub 2020 Nov 26.

GENE-Artificial Feeding Team, Gastroenterology Department, Hospital Garcia de Orta, 2805-267 Almada, Portugal.

Introduction And Aims: Patients undergoing percutaneous endoscopic gastrostomy (PEG) may present protein-energy malnutrition, anemia and deficiencies of hematopoietic factors, e.g., iron, folate and vitamin B12. Read More

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November 2020

The Stimulation of Neurogenesis Improves the Cognitive Status of Aging Rats Subjected to Gestational and Perinatal Deficiency of B9-12 Vitamins.

Int J Mol Sci 2020 Oct 28;21(21). Epub 2020 Oct 28.

Faculté de Médecine, INSERM 1256/University of Lorraine, F-54500 Vandoeuvre-les-Nancy, France.

A deficiency in B-vitamins is known to lead to persistent developmental defects in various organs during early life. The nervous system is particularly affected with functional retardation in infants and young adults. In addition, even if in some cases no damage appears evident in the beginning of life, correlations have been shown between B-vitamin metabolism and neurodegenerative diseases. Read More

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October 2020

Children and adults should avoid consuming animal products to reduce risk for chronic disease: YES.

Am J Clin Nutr 2020 10;112(4):926-930

Research Group of Industrial Microbiology and Food Biotechnology (IMDO), Faculty of Sciences and Bioengineering Sciences, Vrije Universiteit Brussel, Brussels, Belgium.

The consumption of animal products exposes humans to saturated fat, cholesterol, lactose, estrogens, and pathogenic microorganisms, while displacing fiber, complex carbohydrates, antioxidants, and other components needed for health. In the process, consumption of animal products increases the risk for cardiovascular disease, cancer, diabetes, obesity, and other disorders. This dietary pattern also promotes the growth of unhealthful gut bacteria, fostering, among other things, the production of trimethylamine N-oxide, a proinflammatory compound associated with cardiovascular and neurological diseases. Read More

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October 2020

Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis.

J Alzheimers Dis 2020 ;77(2):781-794

Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.

Background: Previous studies have indicated that B vitamin deficiencies are an essential cause of neurological pathology. There is a need to provide evidence of the benefit of B vitamins for the prevention of cognitive decline in community-dwelling older adults.

Objective: To examine the association between intake and plasma levels of vitamins B12, B6, and folate and cognitive function in older populations through a systematic review and meta-analysis. Read More

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September 2021

HIV-associated neurocognitive disorder and HIV-associated myelopathy in a patient with a preserved CD4, but high viral load-a rarely reported phenomenon: a case report and literature review.

BMC Infect Dis 2020 Aug 5;20(1):574. Epub 2020 Aug 5.

Department of Internal Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Despite widespread use of combination antiretroviral therapy (cART), HIV-associated neurocognitive disorder (HAND) and HIV-associated myelopathy (HAM) are not showing significant reduction in there occurrence. The HAM is a progressive myelopathy that often occur synchronously with severe form of the HAND in patients' having advanced immunosuppression. However, co-existence of less severe form of the HAND and HAM in patient with relatively preserved CD4 cells is rarely reported clinical entity in post cART era. Read More

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Hematological findings associated with neurodevelopmental delay in infants with vitamin B12 deficiency.

Authors:
Mahmut Keskin

Acta Neurol Belg 2020 Aug 24;120(4):921-926. Epub 2020 May 24.

Department of Pediatrics, Süleyman Demirel University Medical Faculty, Çünür, 32260, Isparta, Turkey.

In adults with vitamin B12 deficiency, an inverse correlation between the severity of megaloblastic anemia and the degree of neurological dysfunction has been reported. We aimed to evaluate the association between hematological findings and the results of neurodevelopmental assessment in infants. Denver-II developmental screening test (DDST II) was performed in vitamin B12-deficient infants (n = 122), and its relationship with hematological findings was evaluated. Read More

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Vitamin B12 and Folate Concentrations in Recent-onset Type 2 Diabetes and the Effect of Metformin Treatment.

J Clin Endocrinol Metab 2020 06;105(6)

Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research, Düsseldorf, Germany.

Context: Vitamin B12 and folate deficiency are not only linked to hematological, neurological, and cardiovascular diseases, but are also associated with insulin resistance. Metformin can decrease vitamin B12 and folate concentrations.

Objective: To examine (1) effects of short-term metformin treatment on serum holotranscobalamin (holoTC) and folate and (2) their association with insulin sensitivity in recent-onset type 2 diabetes. Read More

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Analysis of fibroblasts from patients with cblC and cblG genetic defects of cobalamin metabolism reveals global dysregulation of alternative splicing.

Hum Mol Genet 2020 07;29(12):1969-1985

Inserm UMRS 1256 NGERE - Nutrition, Genetics, and Environmental Risk Exposure, University of Lorraine, Nancy F-54000, France.

Vitamin B12 or cobalamin (Cbl) metabolism can be affected by genetic defects leading to defective activity of either methylmalonyl-CoA mutase or methionine synthase or both enzymes. Patients usually present with a wide spectrum of pathologies suggesting that various cellular processes could be affected by modifications in gene expression. We have previously demonstrated that these genetic defects are associated with subcellular mislocalization of RNA-binding proteins (RBP) and subsequent altered nucleo-cytoplasmic shuttling of mRNAs. Read More

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Associations of Circulating Methylmalonic Acid and Vitamin B-12 Biomarkers Are Modified by Vegan Dietary Pattern in Adult and Elderly Participants of the Adventist Health Study 2 Calibration Study.

Curr Dev Nutr 2020 Feb 22;4(2):nzaa008. Epub 2020 Jan 22.

Center for Nutrition, Healthy Lifestyle and Disease Prevention, School of Public Health, Loma Linda University, Loma Linda, CA, USA.

Background: Elevated plasma methylmalonic acid (MMA) is a functional biomarker of vitamin B-12 status but limited information is available on its prevalence in US vegetarians.

Objectives: The study examines the prevalence of plasma MMA ≥0.27 µmol/L in those consuming vegetarian diets, its associations with vitamin B-12 intake and biomarkers, and the modifying effect of vegetarian patterns on these associations. Read More

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February 2020

Acute cognitive disorder as the initial manifestation of nitrous oxide abusing: a case report.

Neurol Sci 2021 Feb 13;42(2):755-756. Epub 2019 Dec 13.

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, 610041, People's Republic of China.

Nitrous oxide (NO) is a colorless, odorless gas used as an anesthetic and analgesic. It is also abused as a recreational drug, and such abuse is associated with neurological disorders and psychiatric complications such as myelopathy and, rarely, cognitive impairment. Its abuse has not been associated with acute cognitive decline. Read More

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February 2021

Neurological symptoms of vitamin B12 deficiency: analysis of pediatric patients.

Acta Clin Croat 2019 Jun;58(2):295-302

1Department of Pediatric Neurology, Ege University, School of Medicine, İzmir, Turkey; 2Department of Pediatric Neurology, Karadeniz Technical University, School of Medicine, Trabzon, Turkey.

Vitamin B12 is one of the essential vitamins that affect various systems in the body, including the central nervous system. Vitamin B12 plays an important part in the metabolism of the nervous system, although its exact role under pathological conditions is not fully understood. The purpose of this study was to emphasize the importance of early diagnosis of vitamin B12 deficiency in the light of the characteristics of the patients enrolled. Read More

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The sharp rise of neurological disorders associated with recreational nitrous oxide use in China: a single-center experience and a brief review of Chinese literature.

J Neurol 2020 Feb 26;267(2):422-429. Epub 2019 Oct 26.

Department of Neurology, Shengjing Hospital of China Medical University, Sanhao Street 36, Shenyang, 110004, Liaoning, China.

Introduction: In recent years, there has been a sharp increase in the number of patients with neurological disorders associated with recreational use of nitrous oxide (NO) in China. Here, we summarize the clinical characteristics of patients with neurological disorders associated with NO abuse diagnosed in our Hospital. Further, we conducted a literature search on recent cases reported in mainland China to improve the awareness of the outbreak of neurological disorders associated with NO abuse. Read More

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February 2020

Skin hyperpigmentation: a rare presenting symptom of nitrous oxide abuse.

Clin Toxicol (Phila) 2020 06 16;58(6):476-481. Epub 2019 Sep 16.

Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, China.

Recreational nitrogen oxide (NO) abuse can cause nervous system damage. There was a sharp increase in the number of patients with neurological disorders associated with recreational NO use in China, as recreational NO use became popular in young people nationwide. Among cases with neurological disorders caused by NO abuse, a few showed skin hyperpigmentation, which has rarely been reported. Read More

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Homocysteine, vitamin B12, and folate levels in patients with multiple sclerosis in Chinese population: A case-control study and meta-analysis.

Mult Scler Relat Disord 2019 Nov 10;36:101395. Epub 2019 Sep 10.

Department of Histology and Embryology, Yichun University, Xuefu Road, Yichun, Jiangxi Province, 336000, PR China. Electronic address:

Background: Current studies suggested discrepancies on the correlations between multiple sclerosis (MS) and blood levels of homocysteine (Hcy), vitamin B12 (VB12), and folate. We performed a case-control study and meta-analysis to help resolve the controversy of these lab values in Chinese patients with MS.

Methods: We recruited 80 Chinese MS patients, 86 age/sex matched neurological controls (patients with peripheral vertigo or sleep disorders), and 80 age- and sex-matched healthy controls. Read More

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November 2019

Implication of homocysteine in protein quality control processes.

Biochimie 2019 Oct 30;165:19-31. Epub 2019 Jun 30.

Biochemistry Division, National Institute of Nutrition, Hyderabad, India. Electronic address:

Homocysteine (Hcy) is a key metabolite generated during methionine metabolism. The elevated levels of Hcy in the blood are reffered to as hyperhomocystenimeia (HHcy). The HHcy is caused by impaired metabolism/deficiency of either folate or B12 or defects in Hcy metabolism. Read More

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October 2019