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    123 results match your criteria Vitamin B-12 Associated Neurological Diseases

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    Influence of Diet in Multiple Sclerosis: A Systematic Review.
    Adv Nutr 2017 May 15;8(3):463-472. Epub 2017 May 15.
    Department of Food Science, Regional Campus of International Excellence "Campus Mare Nostrum," University of Murcia, Murcia, Spain;
    Nutrition is considered to be a possible factor in the pathogenesis of the neurological disease multiple sclerosis (MS). Nutrition intervention studies suggest that diet may be considered as a complementary treatment to control the progression of the disease; a systematic review of the literature on the influence of diet on MS was therefore conducted. The literature search was conducted by using Medlars Online International Literature (MEDLINE) via PubMed and Scopus. Read More

    Vitamin B12 deficiency neuropathy; a rare diagnosis in young adults: a case report.
    BMC Res Notes 2017 Jan 28;10(1):72. Epub 2017 Jan 28.
    Department of Medicine, Faculty of Health Sciences, University of Buea and Global Health Dialogue Foundation, Buea, Cameroon.
    Background: Vitamin B12 deficiency is a metabolic disorder with many causes. It often presents with megaloblastic anaemia and neurological disorders which entail prompt treatment. The diagnosis of Vitamin B12 deficiency is challenging in resource limited-settings due to limited access to diagnostic tools and unfamiliarity with the disease, owing to its rarity especially in young people. Read More

    [A Case of Subacute Combined Degeneration Caused by Vitamin B12 Deficiency in a Cervical Spondylosis Surgery Referral].
    No Shinkei Geka 2016 Dec;44(12):1059-1063
    Department of Neurosurgery, Takeda General Hospital.
    A 62-year-old man with a 1-year history of numbness of the extremities, clumsiness, and gait disorder was diagnosed with cervical spondylotic myelopathy at a neighboring clinic and referred to our institution for surgery. The patient had undergone a total gastrectomy 6 years previously. Flattening of the cervical cord, associated with diffuse cervical spondylosis and intramedullary intensity change, was observed on magnetic resonance imaging of the cervical spine. Read More

    Factors Associated with Frontotemporal Dementia in China: A Cross-Sectional Study.
    Arch Med Res 2016 Jul;47(5):388-393
    Department of Neurology, and Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin, China.
    Background And Aims: There is a growing focus on frontotemporal dementia (FTD). However, compared with other major dementias, very little is known about the factors associated with FTD. The present study evaluated candidate factors associated with FTD in the Chinese population. Read More

    B12 deficiency is common in infants and is accompanied by serious neurological symptoms.
    Acta Paediatr 2017 Jan 11;106(1):101-104. Epub 2016 Nov 11.
    Unit of Research, Education and Development, Östersund Hospital, Östersund, Sweden.
    Aim: Adverse neurological symptoms have been linked to vitamin B12 deficiency in infants. This explorative study described the clinical presentation associated with vitamin B12 deficiency in this age group.

    Methods: The study comprised infants who were born between 2004 and 2012 and were tested for vitamin B12 levels after they were admitted to a hospital with neurological symptoms at less than one year of age. Read More

    Vitamin B-12 status and neurologic function in older people: a cross-sectional analysis of baseline trial data from the Older People and Enhanced Neurological Function (OPEN) study.
    Am J Clin Nutr 2016 Sep 17;104(3):790-6. Epub 2016 Aug 17.
    Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, United Kingdom;
    Background: Aging is associated with a progressive decline in vitamin B-12 status. Overt vitamin B-12 deficiency causes neurologic disturbances in peripheral and central motor and sensory systems, but the public health impact for neurologic disease of moderately low vitamin B-12 status in older people is unclear. Evidence from observational studies is limited by heterogeneity in the definition of vitamin B-12 status and imprecise measures of nerve function. Read More

    Large Amplitude Cortical Evoked Potentials in Nonepileptic Patients. Reviving an Old Neurophysiologic Tool to Help Detect CNS Pathology.
    J Clin Neurophysiol 2017 Jan;34(1):84-91
    *Department of Clinical Neurophysiology, Hospital Ramón y Cajal, Madrid, Spain; †Department of Clinical Neurophysiology, Hospital General Universitario de Ciudad Real, Madrid, Spain; ‡Department of Clinical Neurophysiology, Hospital Universitario de Torrejón, Madrid, Spain; and Departments of §Neurology & Neurological Sciences and ‖Neurosurgery, Stanford University School of Medicine, Stanford, California, U.S.A.
    Purpose: Although large amplitude evoked potentials (EPs) are typically associated with progressive myoclonic epilepsy patients, giant EPs imply central nervous system (CNS) hyperexcitability and can be seen in various nonepileptic disorders.

    Methods: We performed a retrospective chart review including history, physical examination, imaging and diagnostic studies of nonepileptic patients with large amplitude somatosensory evoked potentials (SSEPs) and visual evoked potentials (VEPs) during 2007 to 2013. Large amplitude EPs were defined as follows: VEPs (N75-P100) >18 μV; and SSEPs (N20-P25) >6. Read More

    The role of Vitamin B12 in the critically ill--a review.
    Anaesth Intensive Care 2016 Jul;44(4):447-52
    Director, General Intensive Care Unit, Hadassah University Hospital, Jerusalem, Israel.
    Vitamin B12 is an essential micronutrient, as humans have no capacity to produce the vitamin and it needs to be ingested from animal proteins. The ingested Vitamin B12 undergoes a complex process of absorption and assimilation. Vitamin B12 is essential for cellular function. Read More

    Catatonia as an internal medicine disease: infrequent or still underdiagnosed?
    BMJ Case Rep 2016 Apr 22;2016. Epub 2016 Apr 22.
    Department of Medicine, Hospital São Francisco Xavier/CHLO/NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal.
    Catatonia is a motor and behavioural syndrome with multiple psychiatric, general medical and neurological aetiologies that might be simultaneously present. B12 deficiency is a rare, treatable cause of catatonia, not always easy to rule out. The authors present a case of a woman with catatonia associated with severe cyanocobalamin deficiency, admitted to an internal medicine ward. Read More

    [Neuropsychiatric manifestations ushering pernicious anemia].
    Encephale 2015 Dec 4;41(6):550-5. Epub 2015 Sep 4.
    Service de psychiatrie G, hôpital Razi la Mannouaba, faculté de médecine de Tunis, Tunis, Tunisie.
    Biermer disease or pernicious anemia is an autoimmune atrophic gastritis characterized by the lack of secretion of gastric intrinsic factor. This leads to an insufficient absorption of vitamin B12 in the ileum. Clinical manifestations are mainly hematologic. Read More

    Low levels of cobalamin, epidermal growth factor, and normal prions in multiple sclerosis spinal cord.
    Neuroscience 2015 Jul 16;298:293-301. Epub 2015 Apr 16.
    Division of Brain Sciences, Imperial College, London W12 0NN, UK.
    We have previously demonstrated that multiple sclerosis (MS) patients have abnormal cerebrospinal fluid (CSF) levels of the key myelin-related molecules cobalamin (Cbl), epidermal growth factor (EGF), and normal cellular prions (PrP(C)s), thus confirming that some CSF abnormalities may be co-responsible for remyelination failure. We determined the levels of these three molecules in post-mortem spinal cord (SC) samples taken from MS patients and control patients. The control SC samples, almost all of which came from non-neurological patients, did not show any microscopic lesions of any type. Read More

    Pernicious anemia presenting as catatonia: correlating vitamin B12 levels and catatonic symptoms.
    Gen Hosp Psychiatry 2015 May-Jun;37(3):273.e5-7. Epub 2015 Feb 23.
    Université Lille Nord de France, Lille, France; Department of Psychiatry, CHU Lille, Lille, France. Electronic address:
    Pernicious anemia has been associated with various psychiatric manifestations, such as depression, mania and psychosis. Psychiatric symptoms can sometimes occur without hematological and neurological abnormalities and can be prodromal of vitamin B12 deficiency. We report a case of autoimmune B12 deficiency presenting as catatonia without signs of anemia or macrocytosis, in which a correlation was found between the patient's B12 blood levels and catatonic symptoms over time. Read More

    Vitamin B12-responsive neuropathies: A case series.
    Nutr Neurosci 2016 May 24;19(4):162-8. Epub 2015 Feb 24.
    a Section of Palliative Care, Department of Medicine , Yale University School of Medicine and Smilow Cancer Hospital , New Haven , CT , USA.
    Objectives: Neuropathies often accompany vitamin B12 deficiency. Since many neuropathies are linked to oxidative stress and since B12 has both antioxidant and neurotrophic properties, B12 may also be effective treatment in non-deficient subjects. Thus, the characteristics and predictors of B12-responsive neuropathies and their relationship to disorders associated with increased oxidative stress (oxidant risks) were examined. Read More

    Impact of personalized diet and probiotic supplementation on inflammation, nutritional parameters and intestinal microbiota - The "RISTOMED project": Randomized controlled trial in healthy older people.
    Clin Nutr 2015 Aug 8;34(4):593-602. Epub 2014 Oct 8.
    Experimental Medicine Department, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy; Medical University of Innsbruck, Innrain 52, 6020 Innsbruck, Austria.
    Objectives: To assess the impact of a personalized diet, with or without addition of VSL#3 preparation, on biomarkers of inflammation, nutrition, oxidative stress and intestinal microbiota in 62 healthy persons aged 65-85 years.

    Design: Open label, randomized, multicenter study.

    Primary Endpoint: High-sensitivity C-reactive protein. Read More

    Helicobacter pylori and extragastric diseases.
    Helicobacter 2014 Sep;19 Suppl 1:52-8
    Internal Medicine Institute, Catholic University of Rome, Rome, Italy.
    While Helicobacter pylori infection was initially revealed to be associated only with some gastroduodenal diseases, further studies have shown its possible role in several extragastric diseases. For idiopathic thrombocytopenic purpura, sideropenic anemia, and vitamin B12 deficiency, the diagnosis of H. pylori infection is recommended, and there are many other conditions such as cardiovascular, neurological, dermatological, and respiratory diseases in which H. Read More

    Impaired lysosomal cobalamin transport in Alzheimer's disease.
    J Alzheimers Dis 2015 ;43(3):1017-30
    Illawarra Health and Medical Research Institute, University of Wollongong, NSW, Australia School of Biological Sciences, University of Wollongong, NSW, Australia.
    Cobalamin (vitamin B12) is required for erythrocyte formation and DNA synthesis and it plays a crucial role in maintaining neurological function. As a coenzyme for methionine synthase and methylmalonyl-CoA mutase, cobalamin utilization depends on its efficient transit through the intracellular lysosomal compartment and subsequent delivery to the cytosol and mitochondria. Lysosomal function deteriorates in Alzheimer's disease (AD). Read More

    B12 deficiency increases with age in hospitalized patients: a study on 14,904 samples.
    J Gerontol A Biol Sci Med Sci 2014 Dec 25;69(12):1576-85. Epub 2014 Jul 25.
    Service d'Hématologie biologique, Assistance Publique - Hôpitaux de Paris, Groupe Hospitalier Universitaire Henri Mondor, Créteil, France. Faculté de Médecine, Université Paris Est Créteil, Créteil, France.
    Background: Cobalamin deficiency is responsible for hematological, neurological, neurocognitive, and neuropsychiatric impairments and is a risk factor for cardiovascular diseases, particularly in the elderly people.

    Methods: In order to determine B12 status in old inpatients, a total number of 14,904 hospitalized patients in whom B12 measurements were performed in five hospitals in the Paris metropolitan area were included from January 1, 2011 to December 31, 2011. The aims of the study were to determine whether age had an impact on B12 and folate deficiencies and to evaluate correlations between B12 and biological parameters-folate, hemoglobin, mean cell volume, homocystein (tHcy)-and age. Read More

    Two infants with infantile spasms associated with vitamin B12 deficiency.
    Pediatr Neurol 2014 Jul 5;51(1):144-6. Epub 2014 Mar 5.
    Department of Pediatric Neurology, Dr. Sami Ulus Research and Training Hospital of Women's and Children's Health and Diseases, Ankara, Turkey.
    Background: In developing countries, nutritional vitamin B12 deficiency in infants because of maternal deficiency often causes hematological and neurological disorders. However, epilepsy is a rare manifestation of vitamin B12 deficiency. The biological basis for the observed neurological symptoms of infantile vitamin B12 deficiency remains uncertain. Read More

    The Kampo medicine Goshajinkigan prevents neuropathy in breast cancer patients treated with docetaxel.
    Asian Pac J Cancer Prev 2013 ;14(11):6351-6
    Breast Center, Bell Land General Hospital, Japan E-mail :
    Background: Goshajinkigan (GJG) is used for the treatment of several neurological symptoms. We investigated the efficacy of GJG and mecobalamin (B12) against neurotoxicity associated with docetaxel (DOC) in breast cancer patients.

    Materials And Methods: Sixty breast cancer patients were treated with DOC. Read More

    Tropical myelopathies.
    Handb Clin Neurol 2014 ;121:1521-48
    Department of Neurology, Weill Cornell Medical College, Methodist Neurological Institute, Houston, TX, USA. Electronic address:
    A large number of causal agents produce spinal cord lesions in the tropics. Most etiologies found in temperate regions also occur in the tropics including trauma, herniated discs, tumors, epidural abscess, and congenital malformations. However, infectious and nutritional disorders occur with higher prevalence in tropical regions. Read More

    Neurologic aspects of cobalamin (B12) deficiency.
    Handb Clin Neurol 2014 ;120:915-26
    Department of Neurology, Mayo Clinic, Rochester, MN, USA. Electronic address:
    Optimal functioning of the central and peripheral nervous system is dependent on a constant supply of appropriate nutrients. Particularly important for optimal functioning of the nervous system is cobalamin (vitamin B12). Cobalamin deficiency is particularly common in the elderly and after gastric surgery. Read More

    Neuroenhancement with vitamin B12-underestimated neurological significance.
    Nutrients 2013 Dec 12;5(12):5031-45. Epub 2013 Dec 12.
    Academy of Micronutrient Medicine, Zweigertstr. 55, Essen 45130, Germany.
    Vitamin B12 is a cofactor of methionine synthase in the synthesis of methionine, the precursor of the universal methyl donor S-Adenosylmethionine (SAMe), which is involved in different epigenomic regulatory mechanisms and especially in brain development. A Vitamin B12 deficiency expresses itself by a wide variety of neurological manifestations such as paraesthesias, skin numbness, coordination disorders and reduced nerve conduction velocity. In elderly people, a latent Vitamin B12 deficiency can be associated with a progressive brain atrophy. Read More

    Early methyl donor deficiency may induce persistent brain defects by reducing Stat3 signaling targeted by miR-124.
    Cell Death Dis 2013 Aug 8;4:e755. Epub 2013 Aug 8.
    Faculté de Médecine, Inserm U954, Vandoeuvre-lès-Nancy, France.
    The methyl donors folate (vitamin B9) and vitamin B12 are centrepieces of the one-carbon metabolism that has a key role in transmethylation reactions, and thus in epigenetic and epigenomic regulations. Low dietary intakes of folate and vitamin B12 are frequent, especially in pregnant women and in the elderly, and deficiency constitutes a risk factor for various diseases, including neurological and developmental disorders. In this respect, both vitamins are essential for normal brain development, and have a role in neuroplasticity and in the maintenance of neuronal integrity. Read More

    [Neurological disorders related to vitamin B12 deficiency in prisons in Guinea: a 22-case study].
    Bull Soc Pathol Exot 2013 Aug 21;106(3):156-9. Epub 2013 Jun 21.
    Service de neurologie, CHU Conakry, Conakry, République de Guinée.
    Neurological disorders related to vitamin B12 deficiency are common in prisons of tropical Africa. We collected 22 cases (20 men and 2 women). They all showed vitamin B12 deficiency associated with neurological signs that were represented by sclerosis combined with bone marrow (n = 9), peripheral neuropathy (n = 6), cerebellar syndrome (n = 2), a pyramidal syndrome of the lower limbs (n = 4) and optic neuropathy (n = 1). Read More

    [Vitamin B12 deficiency due to nitrous oxide use: unrecognized cause of combined spinal cord degeneration].
    Rev Med Interne 2014 May 14;35(5):328-32. Epub 2013 Jun 14.
    Service de médecine interne, centre hospitalier Poissy-St-Germain, 20, rue du Champ-Gaillard, 78300 Poissy, France.
    Introduction: Nitrous oxide is widely used in anesthesia. It is usually safe but may be associated with severe side effects when it is used repeatedly or on a prolonged time. Here, we report a case of drug-induced subacute combined spinal cord degeneration related to cobalamin deficiency. Read More

    A multicenter retrospective analysis of the clinical features of pernicious anemia in a Korean population.
    J Korean Med Sci 2013 Feb 29;28(2):200-4. Epub 2013 Jan 29.
    Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Korea.
    To determine the approximate incidence and clinical features of pernicious anemia in a Korean population, we retrospectively analyzed clinical data for patients with pernicious anemia who were diagnosed between 1995 and 2010 at five hospitals in Chungnam province. Ninety-seven patients were enrolled, who accounted for 24% of patients with vitamin B(12) deficiency anemia. The approximate annual incidence of pernicious anemia was 0. Read More

    Associations between elevated homocysteine, cognitive impairment, and reduced white matter volume in healthy old adults.
    Am J Geriatr Psychiatry 2013 Feb 22;21(2):164-72. Epub 2013 Jan 22.
    Gerontological Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
    Objectives: Elevated homocysteine has emerged as a risk factor for cognitive impairment even in healthy elderly persons. Reduced brain volume and white matter hyperintensities also occur in healthy elderly as well, but the interrelationships between these have not been well studied. We report these interrelationships in non demented, relatively healthy, community-dwelling older adults from a single East Asian population. Read More

    Vitamin B12 in neurology and ageing; clinical and genetic aspects.
    Biochimie 2013 May 7;95(5):1066-76. Epub 2012 Dec 7.
    School of Medicine, Cardiff University, Gwenfro Units 6/7, Wrexham Technology Park, Wrexham LL17 7YP, Wales, United Kingdom.
    The classic neurological and psychiatric features associated with vitamin B12 deficiency have been well described and are the subject of many excellent review articles. The advent of sensitive diagnostic tests, including homocysteine and methylmalonic acid assays, has revealed a surprisingly high prevalence of a more subtle 'subclinical' form of B12 deficiency, particularly within the elderly. This is often associated with cognitive impairment and dementia, including Alzheimer's disease. Read More

    [Therapeutic and clinical implications of elevated levels of vitamin B12].
    Rev Med Suisse 2012 Oct;8(360):2072-4, 2076-7
    Service de médecine interne, Département de médecine CHUV, 1011 Lausanne.
    In general practice, vitamin B12 levels are measured when searching an origin for an anemic status (usually megaloblastic anemia), for various neurological disorders (usually polyneuropathy) or for neurocognitive disorders. Although the pathologies associated with vitamin B12 deficiency are well known, hypervitaminemic B12 status is often fortuitous and frequent finding. The aim of this article is to present the disease entities associated with hypervitaminemia B12, the clinical implications of this dysvitaminosis and a practical approach when this laboratory abnormality is found. Read More

    Three family members with elevated plasma cobalamin, transcobalamin and soluble transcobalamin receptor (sCD320).
    Clin Chem Lab Med 2013 Mar;51(3):677-82
    Department of Clinical Biochemistry, Aarhus University Hospital, Norrebrogade 44, 8000 Aarhus C, Denmark.
    Background: Plasma cobalamin is requested in order to diagnose cobalamin deficiency and low levels confirm a deficient state. Here, we present three family members with unexpected high levels of cobalamin.

    Methods: We included a patient referred for cobalamin measurement due to neurological symptoms, her son and her daughter. Read More

    Relation of sensory peripheral neuropathy in Sjögren syndrome to anti-Ro/SSA.
    J Clin Rheumatol 2012 Sep;18(6):290-3
    Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
    Background: Sjögren syndrome is a common, chronic autoimmune disease that typically produces inflammation and poor function of the salivary and lacrimal glands. Other organs can be affected, including the nervous system. Sensory peripheral neuropathy is a common manifestation of the disease. Read More

    Mutations in ABCD4 cause a new inborn error of vitamin B12 metabolism.
    Nat Genet 2012 Oct 26;44(10):1152-5. Epub 2012 Aug 26.
    Division of Metabolism, Children's Research Center (CRC), University Children's Hospital, Zürich, Switzerland.
    Inherited disorders of vitamin B12 (cobalamin) have provided important clues to how this vitamin, which is essential for hematological and neurological function, is transported and metabolized. We describe a new disease that results in failure to release vitamin B12 from lysosomes, which mimics the cblF defect caused by LMBRD1 mutations. Using microcell-mediated chromosome transfer and exome sequencing, we identified causal mutations in ABCD4, a gene that codes for an ABC transporter, which was previously thought to have peroxisomal localization and function. Read More

    [Homocysteine, vitamin B-12, folic acid and the cognitive decline in the elderly].
    Pathol Biol (Paris) 2013 Oct 29;61(5):184-92. Epub 2012 May 29.
    Department of Biochemistry, Faculty of Medicine of Sousse, 4002 Sousse, Tunisie. Electronic address:
    Hyperhomocysteinemia is a risk factor for neurological diseases, but the underlying pathophysiology has not been adequately explained. Mild hyperhomocysteinemia, which is sometimes associated with a low plasma level of vitamin B9, B12 and folic acid, is responsible in the toxicity in neural cell by activating NMDA receptor. Indeed, even if vitamin supplementation has clearly proven its efficiency on lowering plasma levels of homocysteine, recent studies do not show any positive effect of vitamin therapy on cognitive function. Read More

    Vitamin B12 transport from food to the body's cells--a sophisticated, multistep pathway.
    Nat Rev Gastroenterol Hepatol 2012 May 1;9(6):345-54. Epub 2012 May 1.
    Department of Biomedicine, Aarhus University, Ole Worms Allé 3, Building 1170, 8000 Aarhus, Denmark.
    Vitamin B(12) (B(12); also known as cobalamin) is a cofactor in many metabolic processes; deficiency of this vitamin is associated with megaloblastic anaemia and various neurological disorders. In contrast to many prokaryotes, humans and other mammals are unable to synthesize B(12). Instead, a sophisticated pathway for specific uptake and transport of this molecule has evolved. Read More

    B-vitamins for neuroprotection: narrowing the evidence gap.
    Biofactors 2012 Mar-Apr;38(2):145-50. Epub 2012 Mar 15.
    Nutrition and Brain Health Laboratory, Institute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel.
    A compelling and extensive epidemiological literature documents the strong association of inadequate status of folate, vitamin B₁₂, and to a lesser degree vitamin B6, with increased risk of neurodegenerative and cerebrovascular disease. Mildly elevated plasma total homocysteine, which is biochemically related to low status of these B-vitamins, is similarly associated with increased risk for these conditions. This, together with experimental data showing that experimental B-vitamin deficiency and/or hyperhomocysteinemia can cause a variety of neurological and vascular deficits in animals, has provided the evidence base and motivation for a growing number of large randomized, double-blind clinical trials aimed at determining the efficacy and safety of B-vitamin supplementation for preserving cognitive function in older adults. Read More

    Reversible isolated sensory axonal neuropathy due to cobalamin deficiency.
    Muscle Nerve 2012 Mar;45(3):428-30
    Department of Neuroscience, University of Padova, Via Giustiniani 5, 35128 Padova, Italy.
    Vitamin B(12) deficiency causes a wide range of hematological, gastrointestinal, and neurological manifestations. The most common neurological complication is subacute combined degeneration, sometimes associated with polyneuropathy. Isolated peripheral neuropathy due to cyanocobalamin deficiency is less frequent, and thus it may be overlooked. Read More

    Folate and vitamin B12: function and importance in cognitive development.
    Nestle Nutr Inst Workshop Ser 2012 31;70:161-71. Epub 2012 Aug 31.
    Nutrition and Brain Health Laboratory, Institute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel.
    The importance of the B vitamins folate and vitamin B12 for healthy neurological development and function is unquestioned. Folate and vitamin B12 are required for biological methylation and DNA synthesis. Vitamin B12 also participates in the mitochondrial catabolism of odd-chain fatty acids and some amino acids. Read More

    Characterization of non-length-dependent small-fiber sensory neuropathy.
    Muscle Nerve 2012 Jan;45(1):86-91
    Department of Neurology, Neurological Institute, Cleveland Clinic, 9500 Euclid Avenue/S90, Cleveland, Ohio 44195, USA.
    Introduction: Non-length-dependent small-fiber sensory neuropathy (NLD-SFSN) is not as well characterized as length-dependent small-fiber sensory neuropathy (LD-SFSN).

    Methods: Sixty-three patients with NLD-SFSN were compared with 175 patients with LD-SFSN for their demographics and disease associations.

    Results: Age was younger in those with NLD-SFSN (45. Read More

    Vitamin B12 and homocysteine levels and 6-year change in peripheral nerve function and neurological signs.
    J Gerontol A Biol Sci Med Sci 2012 May 12;67(5):537-43. Epub 2011 Dec 12.
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA.
    Background: Low vitamin B12 and high homocysteine (Hcy) levels are common in older adults and may be associated with worse neurological function. The aim of this study is to determine whether changes in B12 or Hcy levels are associated with longitudinal changes in peripheral nerve function and clinical neurological signs and symptoms.

    Methods: Participants aged 60 years and older at baseline (n = 678; 72. Read More

    Hashimoto's encephalopathy presenting with micrographia as a typical feature of parkinsonism.
    Neurol Sci 2012 Apr 6;33(2):395-7. Epub 2011 Sep 6.
    Department of Neurology, Hiroshima Prefectural Hospital, 1-5-54 Ujina Kanda, Minami-ku, Hiroshima 734-8530, Japan.
    We describe here a 63-year-old woman who presented with gait disturbance and micrographia. Laboratory tests demonstrated the presence of anti-thyroperoxidase (TPO) antibodies and vitamin B(12) deficiency accompanied by the presence of anti-parietal cell antibodies. Lymphocytosis with increased protein was detected in cerebral spinal fluid (CSF). Read More

    Folate/vitamin-B12 prevents chronic hyperhomocysteinemia-induced tau hyperphosphorylation and memory deficits in aged rats.
    J Alzheimers Dis 2011 ;27(3):639-50
    Department of Pathophysiology, Key Laboratory of Neurological Disease of Education Committee of China, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
    Hyperhomocysteinemia is associated with an increased risk of Alzheimer's disease (AD). Our previous work has demonstrated that combined folate and vitamin B12 (vit-B12) supplementation prevents tau hyperphosphorylation and memory deficits induced by acute administration of homocysteine in young rats. Here, we further investigated whether folate/vit-B12 supplementation is also effective in aged rats with a chronically high level of homocysteine. Read More

    Brain biochemical correlates of the plasma homocysteine level: a proton magnetic resonance spectroscopy study in the elderly subjects.
    Am J Geriatr Psychiatry 2011 Jul;19(7):618-26
    Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
    Background: An elevated plasma homocysteine level has been reported to be associated with various neuropsychiatric diseases. However, little is known about the brain biochemical changes associated with the higher plasma homocysteine level. The main goal of this study was to examine the sex difference in brain biochemical concentrations using brain proton magnetic resonance spectroscopy (H MRS), and to elucidate the biochemical changes associated with plasma homocysteine levels by sex in healthy elderly subjects. Read More

    Utility of measuring vitamin B12 and its active fraction, holotranscobalamin, in neurological vitamin B12 deficiency syndromes.
    J Neurol 2011 Mar 2;258(3):393-401. Epub 2010 Oct 2.
    Department of Neurology, Dresden University of Technology, Fetscherstrasse 74, 01307 Dresden, Germany.
    Vitamin B(12) (VitB(12), cobalamin) deficiency has been associated with various neuropsychiatric conditions, such as peripheral neuropathy, subacute combined degeneration, affective disorders, and cognitive impairment. Current assays analyze vitamin B(12), of which only a small percentage is metabolically active. Measurement of its active fraction, holotranscobalamin, might be of greater relevance, but data in populations with neuropsychiatric populations are lacking. Read More

    Acute presentation of dizziness in vitamin B12 deficient old patient of cardiac disease: a case report.
    Clin Chim Acta 2010 Dec 22;411(23-24):2104-6. Epub 2010 Aug 22.
    GB Pant Hospital, Room 418, Dept of Biochemistry, Academic Block, Jawahar Lal Nehru Marg, New Delhi, India.
    Background: Neuropsychiatric and hematological manifestations of vitamin B12 deficiency are well known. The present report highlights the biochemical basis for the impaired synthesis of DNA and neurological disorders associated with vitamin B12 deficiency.

    Methods: We present a case of an old patient who developed acute ataxia, dizziness and imbalance 2 days after pacemaker implantation in a cardiac care unit. Read More

    Food combination and Alzheimer disease risk: a protective diet.
    Arch Neurol 2010 Jun 12;67(6):699-706. Epub 2010 Apr 12.
    The Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.
    Objective: To assess the association between food combination and Alzheimer disease (AD) risk. Because foods are not consumed in isolation, dietary pattern (DP) analysis of food combination, taking into account the interactions among food components, may offer methodological advantages.

    Design: Prospective cohort study. Read More

    Subacute sensory ataxia and optic neuropathy with thiamine deficiency.
    Nat Rev Neurol 2010 May 23;6(5):288-93. Epub 2010 Mar 23.
    Department of Neurosciences, University of Padova, Clinica Neurologica II, Ospedale S. Antonio, Padova, Italy.
    Background: A 71 year-old man with a history of partial gastrectomy presented to the emergency department with subacute gait instability associated with painful dysesthesias and clumsiness in both hands. 10 years before presentation he had received a diagnosis of megaloblastic anemia, with no neurological involvement, as a result of vitamin B(12) and folate deficiency, for which he was receiving regular supplements.

    Investigations: Neurological examination; routine laboratory testing; MRI of the spine and brain; lumbar puncture; electromyography; sensory, motor and visual evoked potentials, optic nerve optical coherence tomography; immunoelectrophoresis; cryoglobulins; immunological and infection tests; screening for onconeural antibodies; measurement of serum metabolic values, including vitamins B(12) and E, folates, homocysteine, copper, zinc and pyruvic acid; transketolase activity; gastrointestinal endoscopies; and the glucose breath test. Read More

    Chapter 30: historical aspects of the major neurological vitamin deficiency disorders: the water-soluble B vitamins.
    Handb Clin Neurol 2010 ;95:445-76
    Department of Neurology, Veterans Affairs Medical Center, Tomah, WI 54660, USA.
    This historical review addresses major neurological disorders associated with deficiencies of water-soluble B vitamins: beriberi, Wernicke-Korsakoff syndrome, pellagra, neural tube defects, and subacute combined degeneration of the spinal cord. Beriberi: Beriberi was known for millennia in Asia, but was not described by a European until the 17th century when Brontius in the Dutch East Indies reported the progressive sensorimotor polyneuropathy. The prevalence of beriberi increased greatly in Asia with a change in the milling process for rice in the late 19th century. Read More

    Rare sensory and autonomic disturbances associated with vitamin B12 deficiency.
    J Neurol Sci 2009 Dec 31;287(1-2):285-7. Epub 2009 Aug 31.
    Department of Neurology, Wayne State University School of Medicine/Detroit Medical Center, 4201 St Antoine, Detroit, MI 48201, United States.
    Vitamin B12 deficiency is an important nutritional disorder causing neurological manifestations of myelopathy, neuropathy and dementia. Sub-acute combined degeneration (SCD) with involvement of the posterior columns in the cervical and thoracic cord is a common presentation of this disorder. In this case report, we describe a 43 year old woman with pernicious anemia and myelopathy with atypical clinical features. Read More

    MTHFR polymorphisms involved in vitamin B12 deficiency associated with atrophic gastritis.
    Biochem Genet 2009 Oct 12;47(9-10):645-50. Epub 2009 Jun 12.
    Hematology Department, Catholic University, L.go A. Gemelli 8, 00168 Rome, Italy.
    Genetic polymorphisms affecting methylentetrahydrofolate reductase (MTHFR) activity may influence hematological and neurological dysfunction in cobalamin-deficient patients. We studied the prevalence of C677T and A1298C polymorphisms by analyzing genomic DNA in 30 cobalamin-deficient patients. No significant difference was found in 677 and 1298 genotype distribution with respect to hematological parameters, B12 and folate levels, and neurological symptoms. Read More

    Association between cholesterols, homocysteine and silent brain infarcts.
    Intern Med J 2009 Mar;39(3):150-5
    Department of Neurology, Pamukkale University, Denizi, Turkey.
    Background: The aim of this study was to assess the relationship between total plasma homocysteine, cholesterol levels, vitamin B(12), folate, thyroid hormones, urea, ferritin, uric acid, C-reactive protein, cardiovascular risk factors and silent brain infarct (SBI) in patients without any neurological disorder. Whether the factors of interest were associated with SBI is investigated.

    Methods: One hundred and forty-two subjects with a mean age of 52. Read More

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