158 results match your criteria Vitamin B-12 Associated Neurological Diseases

Combined Genome, Transcriptome and Metabolome Analysis in the Diagnosis of Childhood Cerebellar Ataxia.

Int J Mol Sci 2021 Mar 15;22(6). Epub 2021 Mar 15.

Instituto de Investigación Biosanitaria ibs.GRANADA, 18012 Granada, Spain.

Ataxia in children is a common clinical sign of numerous neurological disorders consisting of impaired coordination of voluntary muscle movement. Its most common form, cerebellar ataxia, describes a heterogeneous array of neurologic conditions with uncountable causes broadly divided as acquired or genetic. Numerous genetic disorders are associated with chronic progressive ataxia, which complicates clinical management, particularly on the diagnostic stage. Read More

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Anemia and Hematopoietic Factor Deficiencies in Patients after Endoscopic Gastrostomy: A Nine-Year and 472-Patient Study.

Nutrients 2020 Nov 26;12(12). Epub 2020 Nov 26.

GENE-Artificial Feeding Team, Gastroenterology Department, Hospital Garcia de Orta, 2805-267 Almada, Portugal.

Introduction And Aims: Patients undergoing percutaneous endoscopic gastrostomy (PEG) may present protein-energy malnutrition, anemia and deficiencies of hematopoietic factors, e.g., iron, folate and vitamin B12. Read More

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November 2020

The Stimulation of Neurogenesis Improves the Cognitive Status of Aging Rats Subjected to Gestational and Perinatal Deficiency of B9-12 Vitamins.

Int J Mol Sci 2020 Oct 28;21(21). Epub 2020 Oct 28.

Faculté de Médecine, INSERM 1256/University of Lorraine, F-54500 Vandoeuvre-les-Nancy, France.

A deficiency in B-vitamins is known to lead to persistent developmental defects in various organs during early life. The nervous system is particularly affected with functional retardation in infants and young adults. In addition, even if in some cases no damage appears evident in the beginning of life, correlations have been shown between B-vitamin metabolism and neurodegenerative diseases. Read More

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October 2020

Children and adults should avoid consuming animal products to reduce risk for chronic disease: YES.

Am J Clin Nutr 2020 10;112(4):926-930

Research Group of Industrial Microbiology and Food Biotechnology (IMDO), Faculty of Sciences and Bioengineering Sciences, Vrije Universiteit Brussel, Brussels, Belgium.

The consumption of animal products exposes humans to saturated fat, cholesterol, lactose, estrogens, and pathogenic microorganisms, while displacing fiber, complex carbohydrates, antioxidants, and other components needed for health. In the process, consumption of animal products increases the risk for cardiovascular disease, cancer, diabetes, obesity, and other disorders. This dietary pattern also promotes the growth of unhealthful gut bacteria, fostering, among other things, the production of trimethylamine N-oxide, a proinflammatory compound associated with cardiovascular and neurological diseases. Read More

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October 2020

HIV-associated neurocognitive disorder and HIV-associated myelopathy in a patient with a preserved CD4, but high viral load-a rarely reported phenomenon: a case report and literature review.

BMC Infect Dis 2020 Aug 5;20(1):574. Epub 2020 Aug 5.

Department of Internal Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Despite widespread use of combination antiretroviral therapy (cART), HIV-associated neurocognitive disorder (HAND) and HIV-associated myelopathy (HAM) are not showing significant reduction in there occurrence. The HAM is a progressive myelopathy that often occur synchronously with severe form of the HAND in patients' having advanced immunosuppression. However, co-existence of less severe form of the HAND and HAM in patient with relatively preserved CD4 cells is rarely reported clinical entity in post cART era. Read More

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Hematological findings associated with neurodevelopmental delay in infants with vitamin B12 deficiency.

Mahmut Keskin

Acta Neurol Belg 2020 Aug 24;120(4):921-926. Epub 2020 May 24.

Department of Pediatrics, Süleyman Demirel University Medical Faculty, Çünür, 32260, Isparta, Turkey.

In adults with vitamin B12 deficiency, an inverse correlation between the severity of megaloblastic anemia and the degree of neurological dysfunction has been reported. We aimed to evaluate the association between hematological findings and the results of neurodevelopmental assessment in infants. Denver-II developmental screening test (DDST II) was performed in vitamin B12-deficient infants (n = 122), and its relationship with hematological findings was evaluated. Read More

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Vitamin B12 and Folate Concentrations in Recent-onset Type 2 Diabetes and the Effect of Metformin Treatment.

J Clin Endocrinol Metab 2020 06;105(6)

Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research, Düsseldorf, Germany.

Context: Vitamin B12 and folate deficiency are not only linked to hematological, neurological, and cardiovascular diseases, but are also associated with insulin resistance. Metformin can decrease vitamin B12 and folate concentrations.

Objective: To examine (1) effects of short-term metformin treatment on serum holotranscobalamin (holoTC) and folate and (2) their association with insulin sensitivity in recent-onset type 2 diabetes. Read More

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Associations of Circulating Methylmalonic Acid and Vitamin B-12 Biomarkers Are Modified by Vegan Dietary Pattern in Adult and Elderly Participants of the Adventist Health Study 2 Calibration Study.

Curr Dev Nutr 2020 Feb 22;4(2):nzaa008. Epub 2020 Jan 22.

Center for Nutrition, Healthy Lifestyle and Disease Prevention, School of Public Health, Loma Linda University, Loma Linda, CA, USA.

Background: Elevated plasma methylmalonic acid (MMA) is a functional biomarker of vitamin B-12 status but limited information is available on its prevalence in US vegetarians.

Objectives: The study examines the prevalence of plasma MMA ≥0.27 µmol/L in those consuming vegetarian diets, its associations with vitamin B-12 intake and biomarkers, and the modifying effect of vegetarian patterns on these associations. Read More

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February 2020

Acute cognitive disorder as the initial manifestation of nitrous oxide abusing: a case report.

Neurol Sci 2021 Feb 13;42(2):755-756. Epub 2019 Dec 13.

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, 610041, People's Republic of China.

Nitrous oxide (NO) is a colorless, odorless gas used as an anesthetic and analgesic. It is also abused as a recreational drug, and such abuse is associated with neurological disorders and psychiatric complications such as myelopathy and, rarely, cognitive impairment. Its abuse has not been associated with acute cognitive decline. Read More

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February 2021

Neurological symptoms of vitamin B12 deficiency: analysis of pediatric patients.

Acta Clin Croat 2019 Jun;58(2):295-302

1Department of Pediatric Neurology, Ege University, School of Medicine, İzmir, Turkey; 2Department of Pediatric Neurology, Karadeniz Technical University, School of Medicine, Trabzon, Turkey.

Vitamin B12 is one of the essential vitamins that affect various systems in the body, including the central nervous system. Vitamin B12 plays an important part in the metabolism of the nervous system, although its exact role under pathological conditions is not fully understood. The purpose of this study was to emphasize the importance of early diagnosis of vitamin B12 deficiency in the light of the characteristics of the patients enrolled. Read More

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The sharp rise of neurological disorders associated with recreational nitrous oxide use in China: a single-center experience and a brief review of Chinese literature.

J Neurol 2020 Feb 26;267(2):422-429. Epub 2019 Oct 26.

Department of Neurology, Shengjing Hospital of China Medical University, Sanhao Street 36, Shenyang, 110004, Liaoning, China.

Introduction: In recent years, there has been a sharp increase in the number of patients with neurological disorders associated with recreational use of nitrous oxide (NO) in China. Here, we summarize the clinical characteristics of patients with neurological disorders associated with NO abuse diagnosed in our Hospital. Further, we conducted a literature search on recent cases reported in mainland China to improve the awareness of the outbreak of neurological disorders associated with NO abuse. Read More

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February 2020

Skin hyperpigmentation: a rare presenting symptom of nitrous oxide abuse.

Clin Toxicol (Phila) 2020 06 16;58(6):476-481. Epub 2019 Sep 16.

Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, China.

Recreational nitrogen oxide (NO) abuse can cause nervous system damage. There was a sharp increase in the number of patients with neurological disorders associated with recreational NO use in China, as recreational NO use became popular in young people nationwide. Among cases with neurological disorders caused by NO abuse, a few showed skin hyperpigmentation, which has rarely been reported. Read More

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Homocysteine, vitamin B12, and folate levels in patients with multiple sclerosis in Chinese population: A case-control study and meta-analysis.

Mult Scler Relat Disord 2019 Nov 10;36:101395. Epub 2019 Sep 10.

Department of Histology and Embryology, Yichun University, Xuefu Road, Yichun, Jiangxi Province, 336000, PR China. Electronic address:

Background: Current studies suggested discrepancies on the correlations between multiple sclerosis (MS) and blood levels of homocysteine (Hcy), vitamin B12 (VB12), and folate. We performed a case-control study and meta-analysis to help resolve the controversy of these lab values in Chinese patients with MS.

Methods: We recruited 80 Chinese MS patients, 86 age/sex matched neurological controls (patients with peripheral vertigo or sleep disorders), and 80 age- and sex-matched healthy controls. Read More

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November 2019

Implication of homocysteine in protein quality control processes.

Biochimie 2019 Oct 30;165:19-31. Epub 2019 Jun 30.

Biochemistry Division, National Institute of Nutrition, Hyderabad, India. Electronic address:

Homocysteine (Hcy) is a key metabolite generated during methionine metabolism. The elevated levels of Hcy in the blood are reffered to as hyperhomocystenimeia (HHcy). The HHcy is caused by impaired metabolism/deficiency of either folate or B12 or defects in Hcy metabolism. Read More

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October 2019

[Kidney disease in cobalamin C deficiency].

Nephrol Ther 2019 Jul 23;15(4):201-214. Epub 2019 May 23.

Service de néphrologie, dialyse et transplantation, CHU de Rouen, 1, rue de Germont, 76031 Rouen, France; Inserm U1096, UFR médecine pharmacie, 22, boulevard Gambetta, 76183 Rouen, France.

Cobalamin C deficiency (cblC) is the most common inborn error of vitamin B metabolism. This autosomal recessive disease is due to mutations in MMACHC gene, encoding a cyanocobalamin decyanase. It leads to hyperhomocysteinemia associated with hypomethioninemia and methylmalonic aciduria. Read More

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Vitamin B12 inhibits α-synuclein fibrillogenesis and protects against amyloid-induced cytotoxicity.

Food Funct 2019 May;10(5):2861-2870

State Key Laboratory of Food Nutrition and Safety, Tianjin, 300457, P. R. China.

Vitamin B12 (VB12) is a necessary micronutrient for growth and the development of the nervous system. Severe deficiencies of VB12 have been linked to damage of learning and memory ability and cognitive decline, along with several neurological diseases. Misfolding and aggregation of α-synuclein (αSN) into insoluble fibrils is associated with the onset and progression of Parkinson's disease (PD), which affects tens of millions of elderly patients all over the world. Read More

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Causes of chronic neuropathies: a single-center experience.

Neurol Sci 2019 Aug 18;40(8):1611-1617. Epub 2019 Apr 18.

Unit of Neurology, Neurobiology, Department of Medicine, University Campus Bio-Medico of Rome, via Álvaro del Portillo, 21, 00128, Rome, Italy.

Objectives: Chronic neuropathies are a common cause of neurological disability worldwide. However, few reports have evaluated, in real life, the prevalence of the several conditions which can cause it.

Patients And Methods: The authors reviewed informatic database for outpatient office to confirm identification of chronic neuropathy in a 3-year interval period. Read More

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Developmental Impairments in a Rat Model of Methyl Donor Deficiency: Effects of a Late Maternal Supplementation with Folic Acid.

Int J Mol Sci 2019 Feb 23;20(4). Epub 2019 Feb 23.

Université de Lorraine, Inserm U1256, NGERE, Faculté de Médecine, 9 avenue de la Forêt de Haye, F-54500 Vandoeuvre-lès-Nancy, France.

Vitamins B9 (folate) and B12 act as methyl donors in the one-carbon metabolism which influences epigenetic mechanisms. We previously showed that an embryofetal deficiency of vitamins B9 and B12 in the rat increased brain expression of let-7a and miR-34a microRNAs involved in the developmental control of gene expression. This was reversed by the maternal supply with folic acid (3 mg/kg/day) during the last third of gestation, resulting in a significant reduction of associated birth defects. Read More

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February 2019

Imerslund-Gräsbeck Syndrome in an Infant with a Novel Intronic Variant in the Gene: A Case Report.

Int J Mol Sci 2019 Jan 27;20(3). Epub 2019 Jan 27.

Pediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, Piazza Menghini 1, 06129 Perugia, Italy.

Imerslund-Gräsbeck syndrome (IGS) is a rare autosomal recessive disorder clinically characterized by megaloblastic anemia, benign mild proteinuria, and other nonspecific symptoms. Several pathogenetic variants in the amnionless () or cubilin () genes have been described in IGS. We describe a case of IGS with urinary tract infection and mild but persistent proteinuria at onset in an 11-month-old female child. Read More

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January 2019

Associations between metformin use and vitamin B levels, anemia, and neuropathy in patients with diabetes: a meta-analysis.

J Diabetes 2019 Sep 29;11(9):729-743. Epub 2019 Mar 29.

Department of Endocrinology and Metabolism, Peking University People's Hospital, Beijing, China.

Background: Metformin is first-line therapy for patients with diabetes. However, it may lower vitamin B concentrations, which could have hematological or neurological implications. This meta-analyses reviewed all available studies on associations between metformin use and vitamin B levels, anemia, and neuropathy in diabetic patients. Read More

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September 2019

Homocysteine Modification in Protein Structure/Function and Human Disease.

Physiol Rev 2019 01;99(1):555-604

Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers-New Jersey Medical School, International Center for Public Health , Newark, New Jersey ; and Department of Biochemistry and Biotechnology, Poznań University of Life Sciences , Poznań , Poland.

Epidemiological studies established that elevated homocysteine, an important intermediate in folate, vitamin B, and one carbon metabolism, is associated with poor health, including heart and brain diseases. Earlier studies show that patients with severe hyperhomocysteinemia, first identified in the 1960s, exhibit neurological and cardiovascular abnormalities and premature death due to vascular complications. Although homocysteine is considered to be a nonprotein amino acid, studies over the past 2 decades have led to discoveries of protein-related homocysteine metabolism and mechanisms by which homocysteine can become a component of proteins. Read More

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January 2019

[Neurological pathology associated with vitamin B group deficiency: thiamine, folate and cobalamin].

Nutr Hosp 2018 Sep 7;35(Spec No6):54-59. Epub 2018 Sep 7.


The "fragility" of the nervous system, especially concerning to its nutrition and metabolism, explains why vitamin deficits are an important cause of neurological pathology. Some deficiency diseases, which can be very severe and irreversible, are still present in our environment; diagnosis, which must be early so as not to delay treatment, can be difficult if we do not have them in mind. In this review we address the most relevant neurological diseases associated with thiamine, folate and cobalamin deficiency, and we focus especially combined subacute degeneration and Wernicke-Korsakoff syndrome. Read More

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September 2018

Pernicious anemia associated with cryptogenic cirrhosis: Two case reports and a literature review.

Medicine (Baltimore) 2018 Sep;97(39):e12547

Department of Hepatology, The First Hospital of Jilin University, Jilin University, Changchun, Jilin, China.

Rationale: Pernicious anemia (PA) is an autoimmune gastritis that results from the destruction of gastric parietal cells and the associated lack of an intrinsic factor to bind ingested vitamin B12. While an association between PA and various liver diseases has been rarely reported, reports of associated diseases include primary biliary cholangitis, autoimmune hepatitis, and Interferon-treated hepatitis C. We present 2 cases of PA associated with cryptogenic cirrhosis (CC), which has not been previously reported in the literature. Read More

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September 2018

Gluten and Neuroimmunology. Rare association with Myasthenia Gravis and Literature Review.

Rev Assoc Med Bras (1992) 2018 Apr;64(4):311-314

Ambulatory of neuromuscular diseases.

As the celiac disease (CD), the non-celiac gluten sensitivity (NCGS) has also been associated with several autoimmune manifestations. It is rarely associated with myasthenia gravis (MG). This paper shall introduce the case of a young female patient, initially presenting a peripheral neuropathy framework. Read More

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Mice lacking the transcobalamin-vitamin B12 receptor, CD320, suffer from anemia and reproductive deficits when fed vitamin B12-deficient diet.

Hum Mol Genet 2018 10;27(20):3627-3640

Division of Intramural Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.

In humans, poor nutrition, malabsorption and variation in cobalamin (vitamin B12) metabolic genes are associated with hematological, neurological and developmental pathologies. Cobalamin is transported from blood into tissues via the transcobalamin (TC) receptor encoded by the CD320 gene. We created mice carrying a targeted deletion of the mouse ortholog, Cd320. Read More

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October 2018

Neuropathy by folic acid supplementation in a patient with anaemia and an untreated cobalamin deficiency: a case report.

Clin Obes 2018 Aug 31;8(4):300-304. Epub 2018 May 31.

Obesity Center, Catharina Hospital, Eindhoven, The Netherlands.

The rising rates of bariatric surgery (BS) are accompanied by neurological complications related to nutrient deficiencies. One of the risk factors for neurological complications in BS patients is poor vitamin and mineral supplementation. Prevention, diagnosis and treatment of these disorders are necessary parts of lifelong care after BS. Read More

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No laughing matter: subacute degeneration of the spinal cord due to nitrous oxide inhalation.

J Neurol 2018 May 3;265(5):1089-1095. Epub 2018 Mar 3.

The Royal London Hospital, Emergency Care and Acute Medicine Clinical Academic Group, Neuroscience, Barts Health NHS Trust, London, UK.

Background: Whilst the dangers of 'legal highs' have been widely publicised in the media, very few cases of the neurological syndrome associated with the inhalation of nitrous oxide (NO) have been reported. Here we set out to raise awareness of subacute degeneration of the spinal cord arising from recreational NO use so that formal surveillance programs and public health interventions can be designed.

Methods: Case series documenting the clinical and investigational features of ten consecutive cases of subacute degeneration of the spinal cord presenting to a hospital with a tertiary neurosciences service in East London. Read More

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Evidence From Web-Based Dietary Search Patterns to the Role of B12 Deficiency in Non-Specific Chronic Pain: A Large-Scale Observational Study.

J Med Internet Res 2018 01 5;20(1):e4. Epub 2018 Jan 5.

Microsoft Research, Herzeliya, Israel.

Background: Profound vitamin B12 deficiency is a known cause of disease, but the role of low or intermediate levels of B12 in the development of neuropathy and other neuropsychiatric symptoms, as well as the relationship between eating meat and B12 levels, is unclear.

Objective: The objective of our study was to investigate the role of low or intermediate levels of B12 in the development of neuropathy and other neuropsychiatric symptoms.

Methods: We used food-related Internet search patterns from a sample of 8. Read More

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January 2018

Long-term Outcome of 4 Patients With Transcobalamin Deficiency Caused by 2 Novel TCN2 Mutations.

J Pediatr Hematol Oncol 2017 11;39(8):e430-e436

*Department of Pediatrics, King Abdullah International Medical Research Centre, Genetics Division #King Saud bin Abdulaziz University for Health Science, King Abdulaziz Medical City §Department of Pediatrics ∥Department of Medical Genetics, King Faisal Specialist Hospital and Research Centre ¶Department of Anatomy and Cell Biology, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia †Department of Pediatrics, Genetics & Metabolism, University of Florida, Gainesville, FL ‡Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark.

Cobalamin (vitamin B12 [Cbl]) is an essential cofactor for many biochemical pathways. Transcobalamin (TC) is required to internalize Cbl into the cells through membrane receptor-mediated endocytosis. Cbl is then processed in the cytoplasm and mitochondria by complementation factors leading to its active metabolites; methylcobalamin and 5-deoxyadenosyl-cobalamin. Read More

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November 2017

Influence of Diet in Multiple Sclerosis: A Systematic Review.

Adv Nutr 2017 May 15;8(3):463-472. Epub 2017 May 15.

Department of Food Science, Regional Campus of International Excellence "Campus Mare Nostrum," University of Murcia, Murcia, Spain;

Nutrition is considered to be a possible factor in the pathogenesis of the neurological disease multiple sclerosis (MS). Nutrition intervention studies suggest that diet may be considered as a complementary treatment to control the progression of the disease; a systematic review of the literature on the influence of diet on MS was therefore conducted. The literature search was conducted by using Medlars Online International Literature (MEDLINE) via PubMed and Scopus. Read More

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