2,989 results match your criteria Vitamin A Toxicity


The need to consider context in the evaluation of anti-infectious and immunomodulatory effects of Vitamin A and its derivatives.

Curr Drug Targets 2018 Dec 16. Epub 2018 Dec 16.

FIOCRUZ, Rio de Janeiro. Brazil.

Vitamin A and its derivatives (retinoids) act as potent regulators in many aspects of mammalian reproduction, development, repair, and maintenance of differentiated tissue functioning. Unlike other vitamins, Vitamin A and retinoids, which have hormonal actions, present significant toxicity, which plays roles in clinically relevant situations, such as hypervitaminosis A and retinoic acid ("differentiation") syndrome. Although clinical presentation is conspicuous in states of insufficient or excessive Vitamin A and retinoid concentration, equally relevant effects on host resistance to specific infectious agents, and in the general maintenance of immune homeostasis, may go unnoticed, because their expression requires either pathogen exposure or the presence of inflammatory co-morbidities. Read More

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http://dx.doi.org/10.2174/1389450120666181217095323DOI Listing
December 2018

Supplementation of micronutrients in children and food fortification initiatives in Sri Lanka: benefits versus risks.

Ann N Y Acad Sci 2018 Nov 28. Epub 2018 Nov 28.

Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.

In recent decades, Sri Lanka has made substantial progress in reducing the burden of micronutrient deficiencies in children by the provision of vitamin A megadose and micronutrient supplementation programs for children of 6-23 months, along with universal iodization of salt. Consumption of voluntarily fortified foods by children was also considerably increased. The objective of our study here was to review such interventions, which are beneficial in childhood, and to assess the risk of toxicity due to excessive intakes of iron, vitamin A, and iodine. Read More

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http://doi.wiley.com/10.1111/nyas.13987
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http://dx.doi.org/10.1111/nyas.13987DOI Listing
November 2018
3 Reads

Serum retinyl esters are positively correlated with analyzed total liver vitamin A reserves collected from US adults at time of death.

Am J Clin Nutr 2018 Nov;108(5):997-1005

Interdepartmental Graduate Program in Nutritional Sciences, University of Wisconsin-Madison, Madison, WI.

Background: Minimal human data exist on liver vitamin A (VA) compared with serum biomarkers. Cutoffs of 5% and 10% total serum VA as retinyl esters (REs) suggest a VA intoxication diagnosis.

Objectives: We compared total liver VA reserves (TLRs) with the percentage of total serum VA as REs to evaluate hypervitaminosis with the use of US adult autopsy samples. Read More

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/ajcn/nqy190DOI Listing
November 2018
5 Reads

Upregulation of transient receptor potential melastatin 6 channel expression by rosiglitazone and all-trans-retinoic acid in erlotinib-treated renal tubular epithelial cells.

J Cell Physiol 2018 Nov 21. Epub 2018 Nov 21.

Department of Biopharmaceutical Sciences, Laboratory of Biochemistry, Gifu Pharmaceutical University, Gifu, Japan.

Anti-epidermal growth factor receptor (EGFR) drugs including erlotinib cause a side effect of hypomagnesemia. In lung adenocarcinoma A549 cells, anticancer agents such as cisplatin and doxorubicin dose-dependently increased toxicity, but the effects were significantly suppressed by culturing the cells in low Mg -containing media. To obtain the maximum effect in cancer chemotherapy, it should be necessary to prevent the reduction of body Mg content. Read More

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http://dx.doi.org/10.1002/jcp.27565DOI Listing
November 2018
2 Reads

Alopecia and Associated Toxic Agents: A Systematic Review.

Skin Appendage Disord 2018 Oct 5;4(4):245-260. Epub 2018 Jan 5.

University of California, Irvine, Department of Dermatology, Irvine, California, USA.

Importance/objective: There are a number of toxic agents that can cause alopecia. In this review we summarize the known substances that cause alopecia as one of the clinical signs of overdose or toxicity.

Evidence Review: A search was conducted using PubMed, EMBASE, and Cochrane for studies describing hair loss of any type as a result of exposure to or ingestion of a toxic agent. Read More

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https://www.karger.com/Article/FullText/485749
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http://dx.doi.org/10.1159/000485749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219226PMC
October 2018
7 Reads

Identification of influential proteins in the classical retinoic acid signaling pathway.

Theor Biol Med Model 2018 10 16;15(1):16. Epub 2018 Oct 16.

Department of Mechanical Engineering, University of California Santa Barbara, Santa Barbara, CA, 93106, USA.

Background: In the classical pathway of retinoic acid (RA) mediated gene transcription, RA binds to a nuclear hormone receptor dimer composed of retinoic acid receptor (RAR) and retinoid X receptor (RXR), to induce the expression of its downstream target genes. In addition to nuclear receptors, there are other intracellular RA binding proteins such as cellular retinoic acid binding proteins (CRABP1 and CRABP2) and cytochrome P450 (CYP) enzymes, whose contributions to the RA signaling pathway have not been fully understood. The objective of this study was to compare the significance of various RA binding receptors, i. Read More

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https://tbiomed.biomedcentral.com/articles/10.1186/s12976-01
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http://dx.doi.org/10.1186/s12976-018-0088-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190658PMC
October 2018
7 Reads

Effect of molting on the concentration of plasma 25-hydroxyvitamin D in captive African penguins (Spheniscus demersus).

Comp Biochem Physiol A Mol Integr Physiol 2019 Jan 9;227:100-104. Epub 2018 Oct 9.

Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kitashirakawaoiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan. Electronic address:

Feed intake and body weight are drastically altered in penguins during peri-molting period, and molting is known to affect the nutritional status of vitamin A and E. Although vitamin D status is not known in penguins during peri-molting period, vitamin D intake is supposed to be remarkably altered. The objective of the present study was to clarify the alterations in plasma 25-hydroxyvitamin D (25(OH)D) concentration, the most reliable biomarker for assessing vitamin D status, and vitamin D intake during peri-molting period. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10956433183020
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http://dx.doi.org/10.1016/j.cbpa.2018.09.028DOI Listing
January 2019
5 Reads

Poor Vitamin Status is Associated with Skeletal Muscle Loss and Mucositis in Head and Neck Cancer Patients.

Nutrients 2018 Sep 5;10(9). Epub 2018 Sep 5.

Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2E1, Canada.

Mucositis and muscle wasting are two common toxicity effects of cancer treatment in head and neck cancer (HNC). There is limited data evaluating cancer treatment toxicities in relation to vitamin status. This study aimed to assess changes in vitamin status during HNC treatment in relation to body composition, inflammation and mucositis. Read More

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http://www.mdpi.com/2072-6643/10/9/1236
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http://dx.doi.org/10.3390/nu10091236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165496PMC
September 2018
2 Reads

Effect of vitamin A and vitamin C on attenuation of ivermectin-induced toxicity in male Wistar rats.

Environ Sci Pollut Res Int 2018 Oct 20;25(29):29408-29417. Epub 2018 Aug 20.

School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.

An in vivo study was performed to assay the effects of ivermectin on adult male Wistar rats. Twenty-five male Wistar rats aged 6 to 8 weeks and weighing 150-250 g were divided into five groups of five animals each for the purpose of this study. The groups received ivermectin; a mixture of ivermectin and vitamin A; a mixture of ivermectin and vitamin C; and a mixture of ivermectin, vitamin A, and vitamin C, respectively. Read More

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http://dx.doi.org/10.1007/s11356-018-2961-7DOI Listing
October 2018
4 Reads

Vitamin A and beta (β)-carotene supplementation for cystic fibrosis.

Cochrane Database Syst Rev 2018 08 9;8:CD006751. Epub 2018 Aug 9.

Faculty of Medical Sciences, University of Groningen, A. Deusinglaan 1, Groningen, Netherlands, 9713 AV.

Background: People with cystic fibrosis (CF) and pancreatic insufficiency are at risk of a deficiency in fat-soluble vitamins, including vitamin A. Vitamin A deficiency predominantly causes eye and skin problems, while excessive levels of vitamin A can harm the respiratory and skeletal systems in children and interfere with the metabolism of other fat-soluble vitamins. Most CF centres administer vitamin A as supplements to reduce the frequency of vitamin A deficiency in people with CF and to improve clinical outcomes such as growth, although the recommended dose varies between different guidelines. Read More

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http://doi.wiley.com/10.1002/14651858.CD006751.pub5
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http://dx.doi.org/10.1002/14651858.CD006751.pub5DOI Listing
August 2018
6 Reads

Effects of all-trans retinoic acid (ATRA) in addition to chemotherapy for adults with acute myeloid leukaemia (AML) (non-acute promyelocytic leukaemia (non-APL)).

Cochrane Database Syst Rev 2018 08 6;8:CD011960. Epub 2018 Aug 6.

Cochrane Haematological Malignancies Group, Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.

Background: Acute myeloid leukaemia (AML) is the most common acute leukaemia affecting adults. Most patients diagnosed with AML are at advanced age and present with co-morbidities, so that intensive therapy such as stem cell transplantation (SCT) is impossible to provide or is accompanied by high risks for serious adverse events and treatment-related mortality. Especially for these patients, it is necessary to find out whether all-trans retinoic acid (ATRA), an intermediate of vitamin A inducing terminal differentiation of leukaemic cell lines, added to chemotherapy confers increased benefit or harm when compared with the same chemotherapy alone. Read More

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http://dx.doi.org/10.1002/14651858.CD011960.pub2DOI Listing
August 2018
1 Read

Zedoarondiol Attenuates Endothelial Cells Injury Induced by Oxidized Low-Density Lipoprotein via Nrf2 Activation.

Cell Physiol Biochem 2018 31;48(4):1468-1479. Epub 2018 Jul 31.

Cardiovascular Disease Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Background/aims: Zedoarondiol, a sesquiterpene lactone compound, showed an anti-proliferative activity on vascular smooth muscle cells in our previous study. However, whether it has a beneficial effect on endothelial cells injury induced by oxidized low-density lipoprotein (ox-LDL) remains unclear. This study was designed to investigate the protective effect of zedoarondiol on ox-LDL-induced injury of endothelial cells and explored its underlying mechanism. Read More

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http://dx.doi.org/10.1159/000492257DOI Listing
September 2018
1 Read

Effects of methylmercury and retinol palmitate co-administration in rats during pregnancy and breastfeeding: Metabolic and redox parameters in dams and their offspring.

Ecotoxicol Environ Saf 2018 Oct;162:603-615

Centro de Estudos em Estresse Oxidativo, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2600, Anexo Depto. Bioquímica, Lab 32, CEP 90035-003 Porto Alegre, Rio Grande do Sul, Brazil; Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil. Electronic address:

Ubiquitous low-dose methylmercury (MeHg) exposure through an increased fish consumption represents a global public health problem, especially among pregnant women. A plethora of micronutrients presented in fish affects MeHg uptake/distribution, but limited data is available. Vitamin A (VitA), another fish micronutrient is used in nutritional supplementation, especially during pregnancy. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2018.06.093DOI Listing
October 2018
7 Reads

All Trans Retinoic Acid Attenuates Markers of Neuroinflammation in Rat Brain by Modulation of SIRT1 and NFκB.

Neurochem Res 2018 Sep 18;43(9):1791-1801. Epub 2018 Jul 18.

Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram, 695 581, Kerala, India.

Alcohol abuse affects several neurological pathways and causes significant alterations in the brain. Abstention from alcohol causes only a marginal decrease in oxidative stress and neuro inflammation. Our previous studies had shown that an active metabolite of vitamin A, all trans retinoic acid (ATRA), ameliorates alcohol induced toxicity. Read More

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http://dx.doi.org/10.1007/s11064-018-2595-7DOI Listing
September 2018
1 Read

Time to revisit the strategy of massive vitamin A prophylaxis dose administration to the under five children in India - An analysis of available evidence.

Clin Nutr ESPEN 2017 Oct 19;21:26-30. Epub 2017 Jul 19.

School of Public Health, Department of Community Medicine, Postgraduate Institute of Medical Education & Research, India.

Childhood blindness due to corneal ulceration has historically been prevalent among poor Indian children. To tackle this situation the National Institute of Nutrition (NIN), Hyderabad, India, launched (after field-testing) massive dose based national vitamin A (Vit-A) prophylaxis program. Over a period of time reduction in childhood mortality was also hailed as a beneficial effect of the program. Read More

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http://dx.doi.org/10.1016/j.clnesp.2017.07.001DOI Listing
October 2017
1 Read

Temporal variations in kidney metal concentrations and their implications for retinoid metabolism and oxidative stress response in wild yellow perch (Perca flavescens).

Aquat Toxicol 2018 Sep 9;202:26-35. Epub 2018 Jun 9.

Institut national de la Recherche scientifique (INRS), Centre Eau Terre Environnement, 490 de la Couronne, Québec, QC, G1K 9A9, Canada. Electronic address:

The objective of this study was to determine if temporal variations in tissue metal concentrations are related to biomarkers of retinoid metabolism and oxidative stress responses in juvenile yellow perch (Perca flavescens). To this end, kidney metal (Cd, Cu and Zn) concentrations were measured in fish sampled in spring and fall 2012 in four lakes representing a wide range of water and sediment metal contamination in the Rouyn-Noranda (Quebec) region. Lakes Opasatica and Hélène were considered as reference lakes while lakes Dufault and Marlon were metal-contaminated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0166445X183035
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http://dx.doi.org/10.1016/j.aquatox.2018.06.007DOI Listing
September 2018
11 Reads

Salinomycin induces apoptosis and differentiation in human acute promyelocytic leukemia cells.

Oncol Rep 2018 Aug 20;40(2):877-886. Epub 2018 Jun 20.

Central Laboratory of Yongchuan Hospital, Chongqing Medical University, Chongqing 402160, P.R. China.

At present, acute promyelocytic leukemia (APL) is the most curable form of acute myeloid leukemia and can be treated using all-trans retinoic acid and arsenic trioxide. However, the current treatment of APL is associated with some issues such as drug toxicity, resistance and relapse. Therefore, other strategies are necessary for APL treatment. Read More

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http://dx.doi.org/10.3892/or.2018.6513DOI Listing
August 2018
14 Reads

SC1 inhibits the differentiation of F9 embryonic carcinoma cells induced by retinoic acid.

Acta Biochim Biophys Sin (Shanghai) 2018 Aug;50(8):793-799

College of Veterinary Medicine, Northwest A&F University, Yangling, China.

The ability to self-renew is one of the most important properties of embryonic stem (ES) cells. Pluripotin (SC1), a small molecule with high activity and low toxicity, promotes self-renewal in mouse ES cells. SC1 can noticeably change the morphology of retinoic acid (RA)-induced F9 embryonic carcinoma cells (F9 cells). Read More

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http://dx.doi.org/10.1093/abbs/gmy069DOI Listing
August 2018
1 Read

Desmoglein1 Deficiency Is a Potential Cause of Cutaneous Eruptions Induced by Shuanghuanglian Injection.

Molecules 2018 Jun 19;23(6). Epub 2018 Jun 19.

Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.

Cutaneous eruption is a common drug-adverse reaction, characterised by keratinocytes inflammation and apoptosis. Shuanghuanglian injeciton (SHLI) is a typical Chinese medicine injection, which is used to treat influenza. It has been reported that SHLI has the potential to induce cutaneous adverse eruptions. Read More

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http://dx.doi.org/10.3390/molecules23061477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099613PMC
June 2018
8 Reads

β-apo-10'-carotenoids support normal embryonic development during vitamin A deficiency.

Sci Rep 2018 Jun 11;8(1):8834. Epub 2018 Jun 11.

Department of Food Science, Rutgers Center for Lipid Research, and New Jersey Institute for Food, Nutrition, and Health, Rutgers University, New Brunswick, New Jersey, 08901, United States.

Vitamin A deficiency is still a public health concern affecting millions of pregnant women and children. Retinoic acid, the active form of vitamin A, is critical for proper mammalian embryonic development. Embryos can generate retinoic acid from maternal circulating β-carotene upon oxidation of retinaldehyde produced via the symmetric cleavage enzyme β-carotene 15,15'-oxygenase (BCO1). Read More

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http://dx.doi.org/10.1038/s41598-018-27071-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995931PMC
June 2018
10 Reads

Vitamin A-decorated biocompatible micelles for chemogene therapy of liver fibrosis.

J Control Release 2018 Aug 29;283:113-125. Epub 2018 May 29.

State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China; Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, China Pharmaceutical University, Nanjing 210009, China; Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China; Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, China Pharmaceutical University, Nanjing 210009, China. Electronic address:

Liver fibrosis refers to excessive accumulation of hepatic collagen, which is primarily produced by activated hepatic stellate cells (HSCs). No effective drugs are clinically available to treat this condition, reflecting the fact that antifibrotic drugs do not specifically target activated HSCs. Here, we report the synthesis and evaluation of poly (lactide-co-glycolide)-polyspermine-poly (ethylene glycol)-vitamin A (PLGA-PSPE-PEG-VA), and activated HSC-targeted, biocompatible amphiphilic polymers for co-delivery of chemical (silibinin) and genetic (siCol1α1) drugs that synergistically suppress collagen I accumulation in fibrogenesis. Read More

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http://dx.doi.org/10.1016/j.jconrel.2018.05.032DOI Listing
August 2018
2 Reads

Pseudotumor Cerebri Syndrome with Resolution After Discontinuing High Vitamin A Containing Dietary Supplement: Case Report and Review.

Neuroophthalmology 2018 Jun 1;42(3):169-175. Epub 2017 Sep 1.

Department of Neurology, University of Kentucky, Lexington, Kentucky, USA.

A 24-year-old non-obese, but slightly overweight, female presented with a two-week history of progressive severe headache associated with two days of blurry vision. Clinical exam was significant for bilateral papilledema and an enlarged blind spot on visual field testing. Contrast enhanced MRI head revealed no space occupying lesion. Read More

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http://dx.doi.org/10.1080/01658107.2017.1367931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958954PMC
June 2018
2 Reads

Effects of co-exposure to lead and zinc on redox status, kidney variables, and histopathology in adult albino rats.

Toxicol Ind Health 2018 Jul 27;34(7):469-480. Epub 2018 Apr 27.

Laboratory of Animal Ecophysiology, Faculty of Sciences, University of Sfax, Sfax, Tunisia.

Lead (Pb) is a toxic metal that induces a wide range of biochemical and physiological effects in humans. Oxidative damage has been proposed as a possible mechanism involved in Pb toxicity. The current study was carried out to evaluate the antioxidant activities of zinc (Zn) supplement against lead acetate-induced kidney injury in rats. Read More

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http://dx.doi.org/10.1177/0748233718770293DOI Listing
July 2018
5 Reads

Studies of indirect and direct effects of hypervitaminosis A on rat bone by comparing free access to food and pair-feeding.

Ups J Med Sci 2018 Jun 26;123(2):82-85. Epub 2018 Apr 26.

a Department of Medical Sciences , Section of Clinical Pharmacology, Uppsala University , Uppsala , Sweden.

Background: The most prominent features of hypervitaminosis A in rats are spontaneous fractures and anorexia. Since caloric restriction induces alterations in bone, some effects could be secondary to loss of appetite. To clarify the mechanisms behind vitamin A-induced bone fragility it is necessary to distinguish between direct and indirect effects. Read More

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http://dx.doi.org/10.1080/03009734.2018.1448020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055747PMC

Toxicogenetic study of omeprazole and the modulatory effects of retinol palmitate and ascorbic acid on Allium cepa.

Chemosphere 2018 08 5;204:220-226. Epub 2018 Apr 5.

Laboratory of Genetics and Toxicology (LAPGENIC), Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil.

Omeprazole (OME) is a proton pump inhibitor used for the treatment of various gastric and intestinal disease; however, studies on its effects on the genetic materials are still restricted. The present study aimed to evaluate possible toxicogenic effects of OME in Allium cepa meristems with the application of cytogenetic biomarkers for DNA damage, mutagenic, toxic and cytotoxic effects. Additionally, retinol palmitate (RP) and ascorbic acid (AA) were also co-treated with OME to evaluate possible modulatory effects of OME-induced cytogenetic damages. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.04.021DOI Listing
August 2018
15 Reads

Inhibition of cancer stem cell like cells by a synthetic retinoid.

Nat Commun 2018 04 11;9(1):1406. Epub 2018 Apr 11.

State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.

Developing novel drugs that can abrogate the growth and metastasis of malignant tumors is a major challenge for cancer researchers. Here we describe a novel synthetic retinoid, namely WYC-209, which inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs), known to resist conventional drug treatment, with an IC of 0.19 μM in a dose-dependent manner. Read More

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http://dx.doi.org/10.1038/s41467-018-03877-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895803PMC
April 2018
3 Reads

ATRA attenuate proteinuria via downregulation of TRPC6 in glomerulosclerosis rats induced by adriamycin.

Ren Fail 2018 Nov;40(1):266-272

a Department of Pediatric Nephrology , The First Affiliated Hospital of GuangXi Medical University , Nanning , China.

Objective: In this research, we explored the molecular mechanism of proteinuria in glomerulosclerosis rats and the protective effects of ATRA.

Methods: This research set up three groups: SHO group, GS group, and ATRA group (15 mg/(kg d), Sigma, St. Louis, MO). Read More

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http://dx.doi.org/10.1080/0886022X.2018.1456459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014515PMC
November 2018
6 Reads

Role of cytarabine in paediatric acute promyelocytic leukemia treated with the combination of all-trans retinoic acid and arsenic trioxide: a randomized controlled trial.

BMC Cancer 2018 04 3;18(1):374. Epub 2018 Apr 3.

State Key Laboratory of Experimental Hematology, Department of Paediatrics Haematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin, 300020, People's Republic of China.

Background: The combination of all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) has been suggested to be safe and effective for adult acute promyelocytic leukaemia (APL). As of 2010, the role of cytarabine (Ara-C) in APL was controversial. The aim of this study was to test the efficacy and safety of ATRA and ATO in paediatric APL patients. Read More

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http://dx.doi.org/10.1186/s12885-018-4280-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883545PMC
April 2018
7 Reads

Encapsulation and controlled release of retinol from silicone particles for topical delivery.

J Control Release 2018 May 28;278:37-48. Epub 2018 Mar 28.

NSF Research Triangle Materials Research Science and Engineering Center, Duke University, Durham, NC 27708, USA; Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA; Department of Chemistry, Duke University, Durham, NC 27708, USA. Electronic address:

Retinol, a derivative of vitamin A, is a ubiquitous compound used to treat acne, reduce wrinkles and protect against conditions like psoriasis and ichthyosis. While retinol is used as the primary active ingredient (AI) in many skin care formulations, its efficacy is often limited by an extreme sensitivity to degrade and toxicity at high concentrations. While microencapsulation is an appealing method to help overcome these issues, few microencapsulation strategies have made a major translational impact due to challenges with complexity, cost, limited protection of the AI and poor control of the release of the AI. Read More

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http://dx.doi.org/10.1016/j.jconrel.2018.03.023DOI Listing
May 2018
1 Read

Vitamin A Supplementation by Endotracheal Application of a Nano-encapsulated Preparation Is Feasible in Ventilated Preterm Lambs.

J Aerosol Med Pulm Drug Deliv 2018 Dec 27;31(6):323-330. Epub 2018 Mar 27.

2 Department of Pediatrics, Maastricht University Medical Center , Faculty of Health, Medicine and Lifesciences, School for Oncology and Developmental Biology (GROW), Maastricht, The Netherlands .

Background: Vitamin A (VA) is crucial for lung growth and development. In premature infants, inadequate VA levels are associated with an increased risk of bronchopulmonary dysplasia (BPD). Intramuscular VA supplementation has been shown to decrease the incidence of BPD, but is not widely used in the clinical setting due to concerns about feasibility and pain. Read More

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http://dx.doi.org/10.1089/jamp.2017.1438DOI Listing
December 2018
9 Reads

Selenium and zinc: Two key players against cadmium-induced neuronal toxicity.

Toxicol In Vitro 2018 Apr;48:159-169

Department of Experimental and Clinical Medicine, Histology and Anatomy Section, University of Firenze, Firenze, Italy.

Cadmium (Cd), a worldwide occupational pollutant, is an extremely toxic heavy metal, capable of damaging several organs, including the brain. Its toxicity has been related to neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. The neurotoxic potential of Cd has been attributed to the changes induced in the brain enzyme network involved in counteracting oxidative stress. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08872333183000
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http://dx.doi.org/10.1016/j.tiv.2018.01.007DOI Listing
April 2018
3 Reads

A Possible Link Between Pyriproxyfen and Microcephaly.

PLoS Curr 2017 Nov 27;9. Epub 2017 Nov 27.

Department of Complex Systems, New England Complex Systems Institute, Cambridge, MA, USA.

The Zika virus has been the primary suspect in the large increase in incidence of microcephaly in 2015-6 in Brazil. While evidence for Zika being the cause of some of the cases is strong, its role as the primary cause of the large number of cases in Brazil has not been confirmed. Recently, the disparity between the incidences in different geographic locations has led to questions about the virus's role. Read More

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http://dx.doi.org/10.1371/currents.outbreaks.5afb0bfb8cf31d9a4baba7b19b4edbacDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760164PMC
November 2017
2 Reads

Teratogenic potential of nanoencapsulated vitamin A evaluated on an alternative model organism, the tunicate Ciona intestinalis.

Int J Food Sci Nutr 2018 Nov 16;69(7):805-813. Epub 2018 Jan 16.

a Department of Environmental Science and Policy , University of Milan , Milan , Italy.

Nano-encapsulation is a technology used to pack substances in order to enhance their stability and bioavailability, but this packing may interact with living systems, causing unexpected toxicity. Vitamin A (vit A) is a substance that has received attention, because in developed countries, the increasing availability of supplements is leading to its excessive intake. This study aims to compare teratogenic effects caused by exposure to the traditional formulation of vit A versus nano-encapsulated vit A. Read More

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http://dx.doi.org/10.1080/09637486.2017.1418843DOI Listing
November 2018
4 Reads

Hypercalcemia and acute renal insufficiency following use of a veterinary supplement.

J Bras Nefrol 2017 Oct-Dec;39(4):467-469

Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Florianópolis - SC, Brazil.

A previously healthy 24 yo male presented with a two-month history of epigastric pain, nausea, vomiting, fatigue and malaise. He reported abuse of different substances, including an injectable veterinary vitamin compound, which contains high doses of vitamin A, D and E, and an oily vehicle that induces local edema and enhances muscle volume. Serum creatinine was 3. Read More

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http://dx.doi.org/10.5935/0101-2800.20170082DOI Listing
September 2018
5 Reads

Retinoid Expression in Onchocercal Skin Disease: Pilot Study.

Infect Dis (Auckl) 2017 20;10:1178633617731741. Epub 2017 Sep 20.

Tukuyu Research Centre, National Institute for Medical Research, Tanzania, Tukuyu, Tanzania.

Based on the observation that the parasite selectively absorbs vitamin A from the host, and the known toxicity of vitamin A in higher concentration, it was hypothesized that dying microfilariae (mf) release their stores of vitamin A (retinoids) into the host circulation in toxic concentrations, inducing the signs and symptoms of onchocerciasis. We conducted a pilot study to test the hypothesis in Songea communities in Southern Tanzania, where mass drug administration with ivermectin had not been implemented by the time of the survey. The specific aim was to evaluate the correlation between the diagnosis of onchocerciasis and increased levels of retinoic acid at infection sites. Read More

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http://journals.sagepub.com/doi/10.1177/1178633617731741
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http://dx.doi.org/10.1177/1178633617731741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755798PMC
September 2017
8 Reads

β-carotene and retinol reduce benzo[a]pyrene-induced mutagenicity and oxidative stress via transcriptional modulation of xenobiotic metabolizing enzymes in human HepG2 cell line.

Environ Sci Pollut Res Int 2018 Mar 15;25(7):6320-6328. Epub 2017 Dec 15.

Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, 060-0818, Japan.

Benzo[a]pyrene (B[a]P) is one of the polycyclic aromatic hydrocarbons which is formed due to smoking of foods, incomplete combustion of woods, vehicle exhausts, and cigarettes smokes. B[a]P gets entry into human and animal bodies mainly through their diets. Metabolic activation of B[a]P is required to induce mutagenesis and carcinogenesis in animal and human studies. Read More

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http://dx.doi.org/10.1007/s11356-017-0977-zDOI Listing
March 2018
4 Reads
2.830 Impact Factor

Toxic responses of Sox2 gene in the regeneration of the earthworm Eisenia foetida exposed to Retnoic acid.

Comp Biochem Physiol C Toxicol Pharmacol 2018 Jan 8;204:106-112. Epub 2017 Dec 8.

State Key Laboratory of Marine Resource Utilization in South China Sea, Hainan University, Haikou 570228, China; Institute of Tropical Agriculture and Forestry, Hainan University, Haikou 570228, China. Electronic address:

Exogenous retinoic acid delays and disturbs the regeneration of Eisenia foetida. The stem cell pluripotency factor, Sox2, can play a crucial role in cell reprogramming and dedifferentiation. In this study, we compared the regeneration of Eisenia foetida in different segments after amputation and the effects of retinoic acid on the regeneration of different segments. Read More

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http://dx.doi.org/10.1016/j.cbpc.2017.12.001DOI Listing
January 2018
12 Reads

Dysregulatory effects of retinoic acid isomers in late zebrafish embryos.

Environ Sci Pollut Res Int 2018 Feb 25;25(4):3849-3859. Epub 2017 Nov 25.

Department of Environmental Chemistry, IDAEA-CSIC, Jordi Girona 18-26, 08034, Barcelona, Spain.

All-trans retinoic acid (atRA) and 9-cis retinoic acid (9cRA) are two natural derivatives of vitamin A that contribute to the normal vertebrate development by affecting gene expression through the retinoic acid signalling pathway. We show transcriptomic effects of the ectopic addition of atRA or 9cRA to zebrafish embryos at the posthatching embryonic stage. Exposure for 24 or 72 h to sublethal concentrations of both isomers resulted in characteristic transcriptome changes, in which many proliferation and development-related genes became underexpressed, whereas genes related to retinoid metabolism and some metabolic functions became overrepresented. Read More

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http://dx.doi.org/10.1007/s11356-017-0732-5DOI Listing
February 2018
2 Reads

All-trans-retinoic acid ameliorates doxorubicin-induced cardiotoxicity: in vivo potential involvement of oxidative stress, inflammation, and apoptosis via caspase-3 and p53 down-expression.

Naunyn Schmiedebergs Arch Pharmacol 2018 Jan 30;391(1):59-70. Epub 2017 Oct 30.

Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Damanhour University, Damanhour, 22511, Egypt.

The present study aimed to investigate the potential protective effect of all-trans-retinoic acid (ATRA, a natural derivative of vitamin A) against doxorubicin (DOX)-induced in vivo cardiac toxicity and its underlying mechanisms. Forty male albino rats were allocated into control, ATRA (0.5 mg/kg bwt, intraperitoneally daily), DOX (2. Read More

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http://dx.doi.org/10.1007/s00210-017-1437-5DOI Listing
January 2018
15 Reads

Excess iron: considerations related to development and early growth.

Am J Clin Nutr 2017 Dec 25;106(Suppl 6):1600S-1605S. Epub 2017 Oct 25.

Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA

What effects might arise from early life exposures to high iron? This review considers the specific effects of high iron on the brain, stem cells, and the process of erythropoiesis and identifies gaps in our knowledge of what molecular damage may be incurred by oxidative stress that is imparted by high iron status in early life. Specific areas to enhance research on this topic include the following: longitudinal behavioral studies of children to test associations between iron exposures and mood, emotion, cognition, and memory; animal studies to determine epigenetic changes that reprogram brain development and metabolic changes in early life that could be followed through the life course; and the establishment of human epigenetic markers of iron exposures and oxidative stress that could be monitored for early origins of adult chronic diseases. In addition, efforts to understand how iron exposure influences stem cell biology could be enhanced by establishing platforms to collect biological specimens, including umbilical cord blood and amniotic fluid, to be made available to the research community. Read More

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http://dx.doi.org/10.3945/ajcn.117.155879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701720PMC
December 2017
9 Reads

Vitamin A status and its determinants in patients with cystic fibrosis.

Acta Sci Pol Technol Aliment 2017 Jul-Sep;16(3):345-354

Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poland.

Background: Routine administration of vitamin A, recommended in CF patients, can help to prevent its deficiency. However, high vitamin A supplementation may lead to its excessive level and possible toxicity. Therefore, the aim of the present study was to assess the status of vitamin A and the determinants of its body resources in CF patients. Read More

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http://dx.doi.org/10.17306/J.AFS.0473DOI Listing
February 2018
5 Reads

Retinol and Retinyl Palmitate.

Authors:
Wilbur Johnson

Int J Toxicol 2017 Sep/Oct;36(5_suppl2):53S-58S

1 Senior Scientific Writer/Analyst, Cosmetic Ingredient Review, Washington, DC, USA.

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http://dx.doi.org/10.1177/1091581817716657DOI Listing
October 2018
9 Reads

A transcriptomic approach for evaluating the relative potency and mechanism of action of azoles in the rat Whole Embryo Culture.

Toxicology 2017 12 29;392:96-105. Epub 2017 Sep 29.

National Institute of Public Health and the Environment (RIVM), 3720BA Bilthoven, the Netherlands; Institute for Risk Assessment Sciences (IRAS), Utrecht University, 3584CM Utrecht, the Netherlands.

We evaluated the effect of six azoles on embryonic development in the rat whole embryo culture (WEC). Using the total morphological scoring system (TMS), we calculated the ID concentration (effective dose for 10% decrease in TMS). For evaluating gene specific responses, we combined previously and newly collected transcriptomics data of rat WEC exposed to a total of twelve azoles at their ID for 4h. Read More

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http://dx.doi.org/10.1016/j.tox.2017.09.014DOI Listing
December 2017
10 Reads

Hepatic stellate cell-targeted imatinib nanomedicine versus conventional imatinib: A novel strategy with potent efficacy in experimental liver fibrosis.

J Control Release 2017 Nov 28;266:226-237. Epub 2017 Sep 28.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Liver fibrosis is a global health problem without approved treatment. Imatinib inhibits two key profibrotic pathways; platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGF-β) and thus can be used to treat liver fibrosis. However, conventional imatinib therapy is hampered by low concentration at target tissue and increased toxicity to other tissues especially heart, lung and liver. Read More

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http://dx.doi.org/10.1016/j.jconrel.2017.09.035DOI Listing
November 2017
11 Reads

HOXA9 is critical in the proliferation, differentiation, and malignancy of leukaemia cells both in vitro and in vivo.

Cell Biochem Funct 2017 Oct 29;35(7):433-440. Epub 2017 Sep 29.

Department of Cardiology, Yishui Center Hospital, Linyi, Shandong Province, China.

Progress in the understanding of the molecular mechanism for acute myeloid leukaemia is of great significance to generate new potential targets for treatment. Recent studies showed that HOXA9, a homeodomain-containing transcription factor, is commonly deregulated in acute leukaemia. In this study, we elucidated the direct correlation between HoxA9 expression and progression of leukaemia using 2 different types of leukaemia cells HL-60 and MOLT-3. Read More

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http://dx.doi.org/10.1002/cbf.3293DOI Listing
October 2017
18 Reads

Development of a peptide-modified siRNA nanocomplex for hepatic stellate cells.

Nanomedicine 2018 01 7;14(1):51-61. Epub 2017 Sep 7.

Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, USA. Electronic address:

Insulin-like growth factor 2 receptor (IGF2R) is overexpressed in activated hepatic stellate cells (HSCs) and therefore can be utilized for HSC-specific drug delivery. We recently discovered an IGF2R-specific peptide using a novel biopanning. Here, we adopted biotin-conjugated IGF2R-specific peptide, cholesterol, and vitamin A as the targeting ligands for the neutravidin-based siRNA nanocomplex to deliver PCBP2 siRNA, a potentially antifibrotic agent, to HSCs. Read More

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http://dx.doi.org/10.1016/j.nano.2017.08.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742024PMC
January 2018
17 Reads

Disease-stabilizing treatment based on all-trans retinoic acid and valproic acid in acute myeloid leukemia - identification of responders by gene expression profiling of pretreatment leukemic cells.

BMC Cancer 2017 Sep 6;17(1):630. Epub 2017 Sep 6.

Section for Hematology, Institute of Clinical Science, University of Bergen, Bergen, Norway.

Background: Acute myeloid leukemia (AML) is an aggressive malignancy only cured by intensive therapy. However, many elderly and unfit patients cannot receive such treatment due to an unacceptable risk of treatment-related morbidity and mortality. Disease-stabilizing therapy is then the only possible strategy, one alternative being treatment based on all-trans retinoic acid (ATRA) combined with the histone deacetylase inhibitor valproic acid and possibly low-toxicity conventional chemotherapy. Read More

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http://dx.doi.org/10.1186/s12885-017-3620-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586053PMC
September 2017
12 Reads

Supplementation of all trans retinoic acid ameliorates ethanol-induced endoplasmic reticulum stress.

Arch Physiol Biochem 2018 May 31;124(2):131-138. Epub 2017 Aug 31.

a Department of Biochemistry , University of Kerala , Thiruvananthapuram , Kerala , India.

Context: Molecular pathogenesis of chronic alcoholism is linked to increased endoplasmic reticulum stress. Ethanol is a competitive inhibitor of vitamin A metabolism and vitamin A supplementation aggravates existing liver problems. Hence, we probed into the impact of supplementation of all trans retinoic acid (ATRA), the active metabolite of vitamin A on ethanol-induced endoplasmic reticulcum stress. Read More

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http://dx.doi.org/10.1080/13813455.2017.1369548DOI Listing
May 2018
1 Read

Retinoic acid postconsolidation therapy for high-risk neuroblastoma patients treated with autologous haematopoietic stem cell transplantation.

Cochrane Database Syst Rev 2017 08 25;8:CD010685. Epub 2017 Aug 25.

Pediatric Oncology and Hematology, Children's Hospital, University of Cologne, Kerpener Str. 62, Cologne, Germany, 50937.

Background: Neuroblastoma is a rare malignant disease and mainly affects infants and very young children. The tumours mainly develop in the adrenal medullary tissue, with an abdominal mass as the most common presentation. About 50% of patients have metastatic disease at diagnosis. Read More

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http://dx.doi.org/10.1002/14651858.CD010685.pub3DOI Listing
August 2017
6 Reads