3,083 results match your criteria Vitamin A Toxicity


Refractory hypercalcemia owing to vitamin A toxicity in a 4-year-old boy.

CMAJ 2020 Jun;192(25):E671-E675

Divisions of Paediatric Medicine (Lorenzo, Gill) and Endocrinology (Harrington), Department of Paediatrics, The Hospital for Sick Children and University of Toronto; Division of Clinical Pharmacology and Toxicology (Nadeau), Department of Medicine, University of Toronto, Toronto, Ont.

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http://dx.doi.org/10.1503/cmaj.191568DOI Listing

Effects of IC dose of retinol on metabolomics of RAW264.7 cells.

J Food Biochem 2020 Jun 15:e13327. Epub 2020 Jun 15.

Key Laboratory of Food Nutrition and Safety of SDNU, Provincial Key Laboratory of Animal Resistant Biology, College of Life Science, Shandong Normal University, Jinan, China.

Vitamin A is one of the most multifunctional vitamins in normal human physiology and is involved in several basic physiological processes from embryonic development to adulthood, such as embryogenesis, vision, immunity, cell differentiation, and proliferation. In this study, we conducted H- NMR to evaluate the metabolomic changes in RAW264.7 cells after treatment with retinol at an IC dose to identify its effects on the differential metabolites and main metabolic pathways. Read More

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http://dx.doi.org/10.1111/jfbc.13327DOI Listing
June 2020
0.741 Impact Factor

Nanoencapsulation approaches for oral delivery of vitamin A.

Colloids Surf B Biointerfaces 2020 May 15;193:111121. Epub 2020 May 15.

LAQV, REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Portugal, Rua de Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.

Vitamin A is essential to human health. Encapsulation in lipid nanoparticles was used to overcome vitamin A poor water solubility in beverages. This work aimed to develop and characterize lipid nanoparticles, containing vitamin A, for food fortification, assuring its stability and oral bioaccessibility. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2020.111121DOI Listing

Premature epiphyseal growth plate arrest after isotretinoin therapy for high-risk neuroblastoma: A case series and review of the literature.

Pediatr Blood Cancer 2020 Aug 9;67(8):e28236. Epub 2020 May 9.

Children's Hospital Los Angeles, University of Southern California, Los Angeles, California.

Background: Vitamin A-derived retinoids have been reported to cause skeletal abnormalities ranging from hypercalcemia to premature epiphyseal closure. Isotretinoin is a retinoid used as standard therapy for high-risk neuroblastoma and has been reported to cause premature epiphyseal growth plate arrest.

Procedure: We identified patients from the Children's Hospital Los Angeles (CHLA) database with high-risk neuroblastoma diagnosed from 1991 to 2018 who experienced premature epiphyseal growth plate arrest and compared their characteristics to other patients with high-risk neuroblastoma. Read More

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http://dx.doi.org/10.1002/pbc.28236DOI Listing

Post-natal all-trans-retinoic acid biosynthesis.

Authors:
Joseph L Napoli

Methods Enzymol 2020 17;637:27-54. Epub 2020 Mar 17.

Graduate Program in Metabolic Biology, Nutritional Sciences and Toxicology, University of California, Berkeley, CA, United States. Electronic address:

Generation of the autacoid all-trans-retinoic acid (ATRA) from retinol (vitamin A) relies on a complex metabolon that includes retinol binding-proteins and enzymes from the short-chain dehydrogenase/reductase and aldehyde dehydrogenase gene families. Serum retinol binding-protein delivers all-trans-retinol (vitamin A) from blood to cells through two membrane receptors, Stra6 and Rbpr2. Stra6 and Rbpr2 convey retinol to cellular retinol binding-protein type 1 (Crbp1). Read More

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http://dx.doi.org/10.1016/bs.mie.2020.02.003DOI Listing

Liver toxicity from vitamin A.

JGH Open 2020 Apr 30;4(2):287-288. Epub 2019 May 30.

Department of Gastroenterology & Hepatology Wellington Regional Hospital Wellington New Zealand.

Hepatic toxicity secondary to hypervitaminosis A is extremely rare. We report the case of a 27-year-old Caucasian female who presented for an investigation of abdominal pain, cholestatic liver function tests, and abnormal computerized tomography findings. She had been prescribed isotretinoin for her acne and had subsequently purchased vitamin A online, which she consumed daily for over 18 months. Read More

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http://dx.doi.org/10.1002/jgh3.12201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144761PMC

Hyperbranched lipoid-based lipid nanoparticles for bidirectional regulation of collagen accumulation in liver fibrosis.

J Control Release 2020 May 2;321:629-640. Epub 2020 Mar 2.

State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China; Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, China Pharmaceutical University, Nanjing 210009, China; Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China. Electronic address:

Liver fibrosis leads to over one million deaths annually worldwide. Hepatic stellate cells (HSCs) have been identified as the main executors of liver fibrosis. Unfortunately, no drug has yet been approved for clinical use against liver fibrosis, largely because the tested drugs have been unable to access HSCs and efficiently remove the collagen accumulation involved in fibrogenesis. Read More

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http://dx.doi.org/10.1016/j.jconrel.2020.02.049DOI Listing

Application of a human mesoderm tissue elongation system in vitro derived from human induced pluripotent stem cells to risk assessment for teratogenic chemicals.

Chemosphere 2020 Jul 7;250:126124. Epub 2020 Feb 7.

Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan; Voluntary Body for International Health Care in Universities, Nagoya, Japan. Electronic address:

Toxic compounds from the mother's diet and medication in addition to genetic factors and infection during pregnancy remain risks for various congenital disorders and misbirth. To ensure the safety of food and drugs for pregnant women, establishment of an in vitro system that morphologically resembles human tissues has been long desired. In this study, we focused on dorsal mesoderm elongation, one of the critical early development events for trunk formation, and we established in vitro autonomous elongating tissues from human induced pluripotent stem cells (hiPSCs). Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.126124DOI Listing

Rosuvastatin and retinoic acid may act as 'pleiotropic agents' against β-adrenergic agonist-induced acute myocardial injury through modulation of multiple signalling pathways.

Chem Biol Interact 2020 Feb 30;318:108970. Epub 2020 Jan 30.

Indian Veterinary Research Institute, Izzatnagar, UP, India.

Cardiovascular disorders constitute the principal cause of deaths worldwide and will continue as the major disease-burden by the year 2060. A significant proportion of heart failures occur because of use and misuse of drugs and most of the investigational agents fail to achieve any clinical relevance. Here, we investigated rosuvastatin and retinoic acid for their "pharmacological pleiotropy" against high dose β-adrenergic agonist (isoproterenol)-induced acute myocardial insult. Read More

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http://dx.doi.org/10.1016/j.cbi.2020.108970DOI Listing
February 2020

Molecular characterization and safety assessment of biofortified provitamin A rice.

Sci Rep 2020 Jan 28;10(1):1376. Epub 2020 Jan 28.

Strategic Innovation Platform, International Rice Research Institute (IRRI), Metro Manila, Philippines.

Part of the studies involved in safety assessment of genetically engineered crops includes characterizing the organization, integrity, and stability of the inserted DNA and evaluating the potential allergenicity and toxicity of newly-expressed proteins. Molecular characterization of the introduced DNA in provitamin A biofortified rice event GR2E confirmed insertion of a single copy of the transfer-DNA in the genome and its inheritance as a single locus. Nucleotide sequencing of the inserted DNA confirmed it was introduced without modifications. Read More

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http://dx.doi.org/10.1038/s41598-020-57669-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987151PMC
January 2020

All-Trans Retinoic Acid Enhances Bacterial Flagellin-Stimulated Proinflammatory Responses in Human Monocyte THP-1 Cells by Upregulating CD14.

Biomed Res Int 2019 26;2019:8059312. Epub 2019 Dec 26.

Department of Life Science, Gachon University, Seongnam, Gyeonggi-Do 461-701, Republic of Korea.

All-trans retinoic acid (ATRA), an active form of vitamin A, exerts immunomodulatory functions. In this study, we examined the immune potentiating effect of ATRA on bacterial flagellin-induced NF-B activation and proinflammatory cytokine production in human monocytic cell line THP-1. ATRA treatment significantly enhanced the flagellin-induced NF-B/AP-1 activity in THP-1 via the RAR/RXR pathway. Read More

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http://dx.doi.org/10.1155/2019/8059312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948301PMC

All-trans-retinal induces autophagic cell death via oxidative stress and the endoplasmic reticulum stress pathway in human retinal pigment epithelial cells.

Toxicol Lett 2020 Apr 10;322:77-86. Epub 2020 Jan 10.

Central Laboratory, Department of Laboratory Medicine, Huangyan Hospital of Wenzhou Medical University, Taizhou First People's Hospital, Taizhou, Zhejiang Province, China. Electronic address:

Failure of all-trans-retinal (atRAL) clearance contributes to retina degeneration. However, whether autophagy can be activated by excess atRAL accumulation in retinal pigment epithelial (RPE) cells is not known. This study showed that atRAL provoked mitochondria-associated reactive oxygen species (ROS) production, activated the nuclear factor (erythroid-derived 2)-like 2 and apoptosis in a human RPE cell line, ARPE-19 cells. Read More

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http://dx.doi.org/10.1016/j.toxlet.2020.01.005DOI Listing
April 2020
3.262 Impact Factor

Reduced H3K27me3 leads to abnormal Hox gene expression in neural tube defects.

Epigenetics Chromatin 2019 12 19;12(1):76. Epub 2019 Dec 19.

Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan, 030001, Shanxi, China.

Background: Neural tube defects (NTDs) are severe, common birth defects that result from failure of normal neural tube closure during early embryogenesis. Accumulating strong evidence indicates that genetic factors contribute to NTDs etiology, among them, HOX genes play a key role in neural tube closure. Although abnormal HOX gene expression can lead to NTDs, the underlying pathological mechanisms have not fully been understood. Read More

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http://dx.doi.org/10.1186/s13072-019-0318-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921514PMC
December 2019

The role of cytochrome P4502E1 in the pathogenesis of alcoholic liver disease and carcinogenesis.

Authors:
Helmut K Seitz

Chem Biol Interact 2020 Jan 11;316:108918. Epub 2019 Dec 11.

Centre of Alcohol Research (CAR), University of Heidelberg, Heidelberg and Department of Medicine, Salem Medical Centre, Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2019.108918DOI Listing
January 2020

Valproate and Retinoic Acid in Combination With Decitabine in Elderly Nonfit Patients With Acute Myeloid Leukemia: Results of a Multicenter, Randomized, 2 × 2, Phase II Trial.

J Clin Oncol 2020 01 3;38(3):257-270. Epub 2019 Dec 3.

University Hospital of Ulm, Ulm, Germany.

Purpose: DNA-hypomethylating agents are studied in combination with other epigenetic drugs, such as histone deacetylase inhibitors or differentiation inducers (eg, retinoids), in myeloid neoplasias. A randomized, phase II trial with a 2 × 2 factorial design was conducted to investigate the effects of the histone deacetylase inhibitor valproate and all- retinoic acid (ATRA) in treatment-naive elderly patients with acute myeloid leukemia (AML).

Patients And Methods: Two hundred patients (median age, 76 years; range, 61-92 years) ineligible for induction chemotherapy received decitabine (20 mg/m intravenously, days 1 to 5) alone (n = 47) or in combination with valproate (n = 57), ATRA (n = 46), or valproate + ATRA (n = 50). Read More

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http://dx.doi.org/10.1200/JCO.19.01053DOI Listing
January 2020

Identification of cadmium-produced lipid hydroperoxides, transcriptomic changes in antioxidant enzymes, xenobiotic transporters, and pro-inflammatory markers in human breast cancer cells (MCF7) and protection with fat-soluble vitamins.

Environ Sci Pollut Res Int 2020 Jan 25;27(2):1978-1990. Epub 2019 Nov 25.

Laboratory of Advanced Lipid Analysis, Faculty of Health Sciences, Hokkaido University, Kita 12, Nishi 5, Sapporo, 060-0812, Japan.

Cadmium (Cd) is a toxic metal that is regarded as a metallohormone with estrogen-like properties. The present study aimed at identification of lipid hydroperoxides produced in human breast cancer (MCF7) exposed to cadmium (Cd) at environmentally relevant levels. Cd induced cytotoxicity and oxidative stress and produced a series of 26 lipid hydroperoxide species including 14 phosphatidylcholine hydroperoxides (PC-OOH), 9 triacylglycerol hydroperoxides (TG-OOH), and 3 cholesteryl ester hydroperoxides (CE-OOH). Read More

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http://dx.doi.org/10.1007/s11356-019-06834-zDOI Listing
January 2020
2.828 Impact Factor

Studies on Protection of Astaxanthin from Oxidative Damage Induced by HO in RAW 264.7 Cells Based on H NMR Metabolomics.

J Agric Food Chem 2019 Dec 27;67(49):13568-13576. Epub 2019 Nov 27.

Key Laboratory of Food Nutrition and Safety of SDNU, Provincial Key Laboratory of Animal Resistant Biology, College of Life Science , Shandong Normal University , Jinan 250014 , China.

Astaxanthin (AST) is a fat-soluble and non-vitamin A source of carotenoid that can quench reactive oxygen species and it has strong antioxidant and anti-inflammatory abilities. Herein, we have used HO to establish a model of oxidative damage to RAW 264.7 cells and cells treated with vitamin C as the positive control group. Read More

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http://dx.doi.org/10.1021/acs.jafc.9b04587DOI Listing
December 2019
2.912 Impact Factor

Vitamin A and Wound Healing.

Nutr Clin Pract 2019 Dec;34(6):839-849

Wound Care and Hyperbaric Medical Center of the Department of Plastic Surgery of Wake Forest Baptist Health, Winston-Salem, North Carolina, USA.

Vitamin A is a general term for retinoids. Vitamin A deficiency leads to a variety of cutaneous manifestations. It also functions as a hormone through retinoic acid receptors altering the activity of multiple cell lines. Read More

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http://dx.doi.org/10.1002/ncp.10420DOI Listing
December 2019

An update on the mechanisms related to cell death and toxicity of doxorubicin and the protective role of nutrients.

Food Chem Toxicol 2019 Dec 29;134:110834. Epub 2019 Sep 29.

Department of Physiology, Institute of Nutrition and Food Technology ''José Mataix", Biomedical Research Centre, University of Granada, 18071, Granada, Spain. Electronic address:

Doxorubicin (DOX), is a very effective chemotherapeutic agent against cancer whose clinical use is limited by toxicity. Different strategies have been proposed to attenuate toxicity, including combined therapy with bioactive compounds. This review update mechanisms of action and toxicity of doxorubicin and the role of nutrients like vitamins (A, C, E), minerals (selenium) and n-3 polyunsaturated fatty acids. Read More

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http://dx.doi.org/10.1016/j.fct.2019.110834DOI Listing
December 2019
1 Read

Rubella Virus Infection, the Congenital Rubella Syndrome, and the Link to Autism.

Int J Environ Res Public Health 2019 09 22;16(19). Epub 2019 Sep 22.

School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DT, UK.

Rubella is a systemic virus infection that is usually mild. It can, however, cause severe birth defects known as the congenital rubella syndrome (CRS) when infection occurs early in pregnancy. As many as 8%-13% of children with CRS developed autism during the rubella epidemic of the 1960s compared to the background rate of about 1 new case per 5000 children. Read More

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http://dx.doi.org/10.3390/ijerph16193543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801530PMC
September 2019
8 Reads

Serum beta-carotene modifies the association between phthalate mixtures and insulin resistance: The National Health and Nutrition Examination Survey 2003-2006.

Environ Res 2019 11 8;178:108729. Epub 2019 Sep 8.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA. Electronic address:

Animal models suggest a protective role of antioxidants against the adverse effect of di-2-ethylhexyl phthalate (DEHP) on insulin resistance. However, no epidemiologic study has examined the effects observed in the animal model. We conduct a study to examine associations of urinary concentrations of phthalate metabolites (individually and as a mixture) with insulin resistance, along with potential effect modification by serum antioxidant concentrations. Read More

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http://dx.doi.org/10.1016/j.envres.2019.108729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759414PMC
November 2019

A 2018 Approach to Combating Methotrexate Toxicity Folic Acid and Beyond.

Bull Hosp Jt Dis (2013) 2018 Sep;76(3):151-155

Methotrexate (MTX) is the cornerstone to management across a variety of rheumatic diseases. Effective use and adherence to MTX treatment is dependent on toxicity prevention and management. The major deterrents to patient tolerability and adherence can include GI upset, hepatic transaminase elevation, stomatitis, hair loss, and CNS toxicity. Read More

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September 2018
1 Read

Constitutive androstane receptor mediates PCB-induced disruption of retinoid homeostasis.

Toxicol Appl Pharmacol 2019 10 23;381:114731. Epub 2019 Aug 23.

Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA.

Environmental exposure to polychlorinated biphenyls (PCBs) is associated with an increased risk of incidence of metabolic disease, however the molecular mechanisms underlying this phenomenon are not fully understood. Our study provides new insights into molecular interactions between PCBs and retinoids (vitamin A and its metabolites) by defining a role for constitutive androstane receptor (CAR) in the disruption of retinoid homeostasis by non-coplanar 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153). Administration of four weekly 50 mg/kg doses of PCB153 to C57BL/6 male mice resulted in a significant decline in the tissue concentrations of retinyl esters, retinol and all-trans-retinoic acid (atRA), while no decline in hepatic and adipose tissue retinoid levels were detected in Car-null littermates. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0041008X193033
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http://dx.doi.org/10.1016/j.taap.2019.114731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750730PMC
October 2019
2 Reads

Ascorbic acid and retinol palmitate modulatory effect on omeprazole-induced oxidative damage, and the cytogenetic changes in S. cerevisiae and S180 cells.

Chem Biol Interact 2019 Sep 29;311:108776. Epub 2019 Jul 29.

Laboratory of Genetic Toxicity, Postgraduate Program in Pharmaceutical Sciences, (Federal)(University of Piauí), Teresina (PI)(-)64049-550, Brazil; Northeast Biotechnology Network (RENORBIO), Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina (PI)-64049-550, Brazil.

Omeprazole (OM), a prototype proton pump inhibitor, oxidizes thiol groups and induces DNA damage. The aim of this study was to evaluate the oxidative effects of omeprazole and its interactions with ascorbic acid (AA, 50 μM) and retinol palmitate (RP) in proficient and deficient Saccharomyces cerevisiae strains, as well as levels of cytogenetic damage in Sarcoma 180 (S180) cells. Omeprazole was tested at concentrations of 10, 20 and 40 μg/mL, whereas HO (10 mM), cyclophosphamide (20 mg/mL), and saline (0. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.108776DOI Listing
September 2019
3 Reads

Effects of a high protein diet and liver disease in an in silico model of human ammonia metabolism.

Theor Biol Med Model 2019 07 31;16(1):11. Epub 2019 Jul 31.

Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.

Background: After proteolysis, the majority of released amino acids from dietary protein are transported to the liver for gluconeogenesis or to peripheral tissues where they are used for protein synthesis and eventually catabolized, producing ammonia as a byproduct. High ammonia levels in the brain are a major contributor to the decreased neural function that occurs in several pathological conditions such as hepatic encephalopathy when liver urea cycle function is compromised. Therefore, it is important to gain a deeper understanding of human ammonia metabolism. Read More

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http://dx.doi.org/10.1186/s12976-019-0109-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6670211PMC
July 2019
3 Reads

Nutrient stability in mould-infested feed and mitigating effect of dietary supplemental vitamins in brown laying hens.

Trop Anim Health Prod 2020 Jan 26;52(1):293-299. Epub 2019 Jul 26.

Department of Animal Production, University of Ilorin, Ilorin, Kwara State, Nigeria.

A 10-week study was conducted to assess the impact of mould infestation on nutrient stability of feed and the mitigating effect of supplemental tocopherol, retinol or a multivitamin on performance and hepatic histology of ISA Brown laying chickens. Two batches of corn were obtained: the aflasafe corn used in preparing control diet and corn with physical evidence of mould used in preparing diets 2 to 5 containing no supplemental vitamin, tocopherol, retinol or a branded multivitamin supplementations respectively. One hundred and fifty (150) laying chickens used were completely randomized into five dietary treatments with three replicates of 10 birds each. Read More

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http://dx.doi.org/10.1007/s11250-019-02016-8DOI Listing
January 2020

The potential of retinoids for combination therapy of lung cancer: Updates and future directions.

Pharmacol Res 2019 09 26;147:104331. Epub 2019 Jun 26.

Cancer Drug Resistance Laboratory, Department of Life Science, National Institute of Technology Rourkela, Odisha, 769008, India. Electronic address:

Lung cancer is the most common cancer-related death worldwide. Natural compounds have shown high biological and pharmaceutical relevance as anticancer agents. Retinoids are natural derivatives of vitamin A having many regulatory functions in the human body, including vision, cellular proliferation and differentiation, and activation of tumour suppressor genes. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.104331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066582PMC
September 2019
6 Reads

Dietary Aroclor 1254-Induced Toxicity on Antioxidant Capacity, Immunity and Energy Metabolism in Chinese Mitten Crab : Amelioration by Vitamin A.

Front Physiol 2019 12;10:722. Epub 2019 Jun 12.

Laboratory of Aquaculture Nutrition and Environmental Health, School of Life Sciences, East China Normal University, Shanghai, China.

Effects of dietary Polychlorinated biphenyl (PCB) exposure and dietary vitamin A supplementation on Chinese mitten crab were studied with the aim to explain dietary PCB toxicity and toxic alleviation by vitamin A intake in crab. Four diets were used including three experimental diets containing 0, 80000 or 240000 IU/kg vitamin A with each experimental diet containing 10 mg PCB/kg diet, and a control diet (without vitamin A and PCB supplementation) in 56 days feeding trial. Crabs fed the PCB-only diet had significantly lower weight gain than those fed the control diet. Read More

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http://dx.doi.org/10.3389/fphys.2019.00722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581683PMC
June 2019
6 Reads

A new pragmatic design for dose escalation in phase 1 clinical trials using an adaptive continual reassessment method.

BMC Cancer 2019 Jun 26;19(1):632. Epub 2019 Jun 26.

Cancer Prevention Trials Unit, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK.

Background: A key challenge in phase I trials is maintaining rapid escalation in order to avoid exposing too many patients to sub-therapeutic doses, while preserving safety by limiting the frequency of toxic events. Traditional rule-based designs require temporarily stopping recruitment whilst waiting to see whether enrolled patients develop toxicity. This can be both inefficient and introduces logistic challenges to recruitment in the clinic. Read More

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http://dx.doi.org/10.1186/s12885-019-5801-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595589PMC
June 2019
2 Reads

Mitochondrial oxidative stress-induced brain and hippocampus apoptosis decrease through modulation of caspase activity, Ca influx and inflammatory cytokine molecular pathways in the docetaxel-treated mice by melatonin and selenium treatments.

Metab Brain Dis 2019 08 13;34(4):1077-1089. Epub 2019 Jun 13.

Neuroscience Research Center, Suleyman Demirel University, Isparta, Turkey.

Docetaxel (DOCE) is widely used to treat several types of glioblastoma. Adverse effects DOCE seriously limit its clinical use in several tissues. Its side effects on brain cortex and hippocampus have not been clarified yet. Read More

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http://link.springer.com/10.1007/s11011-019-00428-x
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http://dx.doi.org/10.1007/s11011-019-00428-xDOI Listing
August 2019
10 Reads

Vitamins (A&D) and Isoprenoid (Chenodeoxycholic acid) molecules are accompanied by Th1 immunostimulatory response and therapeutic cure in vivo: possible antileishmanial drugs.

Sci Rep 2019 06 12;9(1):8531. Epub 2019 Jun 12.

Department of Medical Parasitology, Postgraduate Institute of Medical Education and Research, 160012, Chandigarh, India.

Investigation of immune modulatory anti-leishmanial molecules is now being strongly encouraged to overcome the immunosuppression manifested during visceral leishmaniasis (VL), resistance, toxicity and high cost associated with conventional therapeutics. In the present study, we explored the protective efficacy of vitamin D, retinoic acid and isoprenoid chenodeoxycholic acid (CDCA) combinations against L. donovani infected BALB/c mice. Read More

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http://dx.doi.org/10.1038/s41598-019-44630-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562038PMC
June 2019
6 Reads
5.078 Impact Factor

Immunohistochemical profile of CD markers in experimental neural tube defect.

Biotech Histochem 2019 Nov 11;94(8):617-627. Epub 2019 Jun 11.

Department of Histology-Embryology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.

Neural tube defects (NTDs) are the second most common birth defects worldwide. Stem cells play a critical role in the mechanisms underlying NTDs. We established an experimental NTD model in rats using retinoic acid (RA). Read More

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http://dx.doi.org/10.1080/10520295.2019.1622783DOI Listing
November 2019
10 Reads

The selective estrogen receptor modulator raloxifene mitigates the effect of all--retinal toxicity in photoreceptor degeneration.

J Biol Chem 2019 06 9;294(24):9461-9475. Epub 2019 May 9.

From the Gavin Herbert Eye Institute, Department of Ophthalmology, University of California, Irvine, California 92697,

The retinoid cycle is a metabolic process in the vertebrate retina that continuously regenerates 11--retinal (11-RAL) from the all--retinal (atRAL) isomer. atRAL accumulation can cause photoreceptor degeneration and irreversible visual dysfunction associated with incurable blinding retinal diseases, such as Stargardt disease, retinitis pigmentosa (RP), and atrophic age-related macular degeneration (AMD). The underlying cellular mechanisms leading to retinal degeneration remain uncertain, although previous studies have shown that atRAL promotes calcium influx associated with cell apoptosis. Read More

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http://dx.doi.org/10.1074/jbc.RA119.008697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579480PMC
June 2019
14 Reads

The evaluation of embryotoxicity of Ligusticum chuanxiong on mice and embryonic stem cells.

J Ethnopharmacol 2019 Jul 20;239:111895. Epub 2019 Apr 20.

School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China. Electronic address:

Ethnopharmacological Relevance: Chuanxiong (Chuanxiong Rhizoma, CR), the dried rhizome of Ligusticum chuanxiong Hort, has been used during pregnancy for more than 2000 years. However, the embryotoxicity of CR was not evaluated so far. The purpose of this study was to examine the safety and rational use of CR during pregnancy on mice and mouse embryonic stem cell (ES), and to explore the mechanism of embryotoxicity. Read More

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http://dx.doi.org/10.1016/j.jep.2019.111895DOI Listing
July 2019
4 Reads

All-trans-retinoic acid activated mast cells via Mas-related G-protein-coupled receptor-X2 in retinoid dermatitis.

Contact Dermatitis 2019 Sep 22;81(3):184-193. Epub 2019 May 22.

Department of Dermatology, Northwest Hospital, The Second Hospital Affiliated to Xi'an Jiaotong University, Xi'an, China.

Background: Retinoic acid (RA)-induced dermatitis is the most frequent side-effect limiting its widespread use. However, the exact mechanisms triggering dermatitis are not fully understood, including the role of skin mast cells. The newly discovered Mas-related G-protein-coupled receptor-X2 (MRGPRX2) in mast cells mediates pseudoallergic drug reactions in several types of dermatitis. Read More

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http://dx.doi.org/10.1111/cod.13292DOI Listing
September 2019
6 Reads

Development of MART for the Rapid Production of Nanostructured Lipid Carriers Loaded with All-Trans Retinoic Acid for Dermal Delivery.

AAPS PharmSciTech 2019 Apr 12;20(4):162. Epub 2019 Apr 12.

Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.

All-trans retinoic acid (ATRA) has been regarded as a wonder drug for many dermatological complications; however, its application is limited due to the extreme irritation, and toxicity seen once it has sufficiently concentrated into the bloodstream from the skin. Thus, the present study was aimed to increase the entrapment of ATRA and minimize its transdermal permeation. ATRA incorporated within nanostructured lipid carriers (NLCs) were produced by a green and facile thin lipid-film based microwave-assisted rapid technique (MART). Read More

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http://dx.doi.org/10.1208/s12249-019-1307-1DOI Listing
April 2019
8 Reads

An in vitro developmental neurotoxicity screening assay for retinoic acid-induced neuronal differentiation using the human NT2/D1 cell line.

Neurotoxicology 2019 07 11;73:258-264. Epub 2019 Apr 11.

The Dow Chemical Company, Midland, MI, USA.

Traditional approaches (e.g., neurobehavior, neuropathology) can detect alterations in apical endpoints indicative of developmental neurotoxicity (DNT). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0161813X183025
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http://dx.doi.org/10.1016/j.neuro.2019.04.005DOI Listing
July 2019
1 Read

The use of 3D cultures of MCF-10A and MCF-12A cells by high content screening for effect-based analysis of non-genotoxic carcinogens.

Toxicol In Vitro 2019 Sep 8;59:55-63. Epub 2019 Apr 8.

German Federal Institute for Risk Assessment, Department of Food Safety, Max-Dohrn-Str. 8-10, 10589 Berlin, Germany. Electronic address:

The human breast epithelial cell lines MCF-10A and MCF-12A form well-differentiated acinus-like structures when grown in three-dimensional matrigel culture over a period of 20 days. In the present study, both cell lines were tested for their suitability to serve as an effect-based in vitro test system for non-genotoxic carcinogens. A software solution for automated Acinus Detection And Morphological Evaluation (ADAME) was developed to automatically acquire acinus images and to determine morphological parameters such as acinus size, lumen size, and acinus roundness. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08872333183081
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http://dx.doi.org/10.1016/j.tiv.2019.04.008DOI Listing
September 2019
18 Reads

A 3D bioprinted hydrogel mesh loaded with all-trans retinoic acid for treatment of glioblastoma.

Eur J Pharmacol 2019 Jul 8;854:201-212. Epub 2019 Apr 8.

Laboratory for Innovations in Microengineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC V8P 5C2, Canada; Centre for Advanced Materials and Related Technologies (CAMTEC), University of Victoria, Victoria, BC, V8P 5C2, Canada; Centre for Biomedical Research (CBR), University of Victoria, Victoria, BC, V8P 5C2, Canada. Electronic address:

Treatment of glioblastoma (GBM), as the most lethal type of brain tumor, still remains a major challenge despite the various therapeutic approaches developed over the recent decades. GBM is considered as one of the most therapy-resistant human tumors. Treatment with temozolomide (TMZ) chemotherapy and radiotherapy in GBM patients has led to 30% of two-year survival rate (American Brain Tumor Association), representing a demanding field to develop more effective therapeutic strategies. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.04.007DOI Listing
July 2019
32 Reads
2.532 Impact Factor

EARLY VITAMIN A SUPPLEMENTATION IMPROVES THE OUTCOME OF RETINOPATHY OF PREMATURITY IN EXTREMELY PRETERM INFANTS.

Retina 2020 Jun;40(6):1176-1184

Department of Neonatology, Shangqiu People's Hospital, Shangqiu, China.

Purpose: This study assessed the efficacy and safety of early vitamin A (VA) supplementation to improve outcomes of retinopathy of prematurity in extremely preterm infants.

Methods: A total of 262 eligible extremely preterm infants underwent randomization; of these, 132 were assigned to the VA group and 130 to the control group. The infants were administered a solution of VA (1,500 IU/day), added to their enteral feeds as soon as minimal feeding was introduced and continued for 28 days or until discharge. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242171PMC
June 2020
4 Reads

Dosage considerations in the combined use of ocular-specific vitamins and nutrients and multivitamin products: A systemic review and analysis.

J Am Pharm Assoc (2003) 2019 May - Jun;59(3):423-431. Epub 2019 Apr 1.

Objectives: To provide guidance for safe and appropriate vitamin and mineral supplementation regimens for patients who use vitamins marketed for ocular use concurrently with general-purpose multivitamin (MVI) supplementation.

Data Sources: Primary and tertiary evidence was compiled from secondary literature reference databases.

Study Selection: Dosage exposure with the use of supplements marketed for the prevention of ocular disease, including those recommended by the Age-Related Eye Disease Studies (AREDS), when used in combination with conventional MVI/nutrient products was determined. Read More

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http://dx.doi.org/10.1016/j.japh.2019.01.013DOI Listing
April 2019
7 Reads

Silica nanoparticle-exposure during neuronal differentiation modulates dopaminergic and cholinergic phenotypes in SH-SY5Y cells.

J Nanobiotechnology 2019 Apr 1;17(1):46. Epub 2019 Apr 1.

Division of Veterinary Pharmacology and Toxicology, Vetsuisse Faculty, University of Bern, Laenggassstrasse 124, 3012, Bern, Switzerland.

Background: Silica-ε-polycaprolactone-nanoparticles (SiPCL-NPs) represent a promising tool for laser-tissue soldering in the brain. After release of the SiPCL-NPs in the brain, neuronal differentiation might be modulated. The present study was performed to determine effects of SiPCL-NP-exposure at different stages of neuronal differentiation in neuron-like SH-SY5Y cells. Read More

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https://jnanobiotechnology.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12951-019-0482-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442417PMC
April 2019
17 Reads

A dual deformable liposomal ointment functionalized with retinoic acid and epidermal growth factor for enhanced burn wound healing therapy.

Biomater Sci 2019 May;7(6):2372-2382

Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

An ointment containing retinoic acid deformable liposomes (TRA DLs) and epidermal growth factor cationic deformable liposomes (EGF CDLs) was prepared for the treatment of deep partial-thickness burns. The characterization tests confirmed both liposomes featured small particle sizes, high drug entrapment efficiencies and sustained drug release behavior. Compared with the free drug, TRA DLs and EGF CDLs exhibited superior skin permeation and remarkably increased drug deposition by 2. Read More

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http://dx.doi.org/10.1039/c8bm01569dDOI Listing
May 2019
1 Read

Transcriptomic responses of regenerating earthworms (Eisenia foetida) to retinoic acid reveals the role of pluripotency genes.

Chemosphere 2019 Jul 20;226:47-59. Epub 2019 Mar 20.

State Key Laboratory of Marine Resource Utilization in South China Sea, Hainan University, Haikou, 570228, China; College of Life Science, Hainan Normal University, Haikou, 571158, China. Electronic address:

Exogenous retinoic acid (RA) delays and disturbs the regeneration of Eisenia foetida and inhibits the expression of pluripotent gene Sox2. However, studies of E. foetida conducted at the molecular level have been unable to elucidate its regeneration and mechanisms of RA effects on its regeneration. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.03.111DOI Listing
July 2019
6 Reads
3.340 Impact Factor

Retinol isotope dilution accurately predicts liver reserves in piglets but overestimates reserves in lactating sows.

Exp Biol Med (Maywood) 2019 05 19;244(7):579-587. Epub 2019 Mar 19.

Interdepartmental Graduate Program in Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.

Impact Statement: Vitamin A (VA) deficiency and hypervitaminosis A have been reported in groups of people worldwide. Conventional biomarkers of VA deficiency (e.g. Read More

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http://dx.doi.org/10.1177/1535370219838785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545696PMC
May 2019
8 Reads

Effects of vitamin A and vitamin E on attenuation of titanium dioxide nanoparticles-induced toxicity in the liver of male Wistar rats.

Mol Biol Rep 2019 Jun 18;46(3):2919-2932. Epub 2019 Mar 18.

School of Medicine, Hamadan University of Medical Sciences, Hamadan, 65178, Iran.

The increasing application of titanium dioxide nanoparticles (NTiO) in life and the toxicity potential of these nanoparticles have raised concerns about their detrimental effects on human health. This study was conducted to investigate the hepatoprotective effects of vitamin E and vitamin A against hepatotoxicity induced by NTiO in rats. Thirty-six male Wistar rats were randomly divided into six groups of six rats each. Read More

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http://link.springer.com/10.1007/s11033-019-04752-4
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http://dx.doi.org/10.1007/s11033-019-04752-4DOI Listing
June 2019
28 Reads

The synthetic retinoid ST1926 attenuates prostate cancer growth and potentially targets prostate cancer stem-like cells.

Mol Carcinog 2019 07 18;58(7):1208-1220. Epub 2019 Mar 18.

Department of Anatomy, Cell Biology, and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.

Retinoids are vitamin A derivatives that regulate crucial biological processes such as cellular proliferation, apoptosis, and differentiation. The use of natural retinoids in cancer therapy is limited due to their toxicity and the acquired resistance by cancer cells. Therefore, synthetic retinoids were developed, such as the atypical adamantyl retinoid ST1926 that provides enhanced bioavailability and reduced toxicity. Read More

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http://dx.doi.org/10.1002/mc.23004DOI Listing
July 2019
10 Reads
4.808 Impact Factor