Toxicol Sci 2017 Jan 25. Epub 2017 Jan 25.
Department of Medicine, Columbia University, New York, NY 10032, USA.
Bisphenol A (BPA, 2,2-bis(4-hydroxyphenyl) propane) is a widely used industrial chemical. The extensive distribution of BPA in the environment poses risks to humans however the molecular mechanisms underlying BPA toxicity as well as its effective detoxification and elimination are not well understood. We have investigated specifically for BPA the notion raised in the literature that the optimal sensing, detoxification and elimination of xenobiotics requires retinoid (natural derivatives and synthetic analogs of vitamin A) actions. Read More