3,010 results match your criteria Vitamin A Toxicity


EARLY VITAMIN A SUPPLEMENTATION IMPROVES THE OUTCOME OF RETINOPATHY OF PREMATURITY IN EXTREMELY PRETERM INFANTS.

Retina 2019 Apr 5. Epub 2019 Apr 5.

Department of Neonatology, Shangqiu People's Hospital, Shangqiu, China.

Purpose: This study assessed the efficacy and safety of early vitamin A (VA) supplementation to improve outcomes of retinopathy of prematurity in extremely preterm infants.

Methods: A total of 262 eligible extremely preterm infants underwent randomization; of these, 132 were assigned to the VA group and 130 to the control group. The infants were administered a solution of VA (1,500 IU/day), added to their enteral feeds as soon as minimal feeding was introduced and continued for 28 days or until discharge. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002543DOI Listing
April 2019
1 Read

Dosage considerations in the combined use of ocular-specific vitamins and nutrients and multivitamin products: A systemic review and analysis.

J Am Pharm Assoc (2003) 2019 Apr 1. Epub 2019 Apr 1.

Objectives: To provide guidance for safe and appropriate vitamin and mineral supplementation regimens for patients who use vitamins marketed for ocular use concurrently with general-purpose multivitamin (MVI) supplementation.

Data Sources: Primary and tertiary evidence was compiled from secondary literature reference databases.

Study Selection: Dosage exposure with the use of supplements marketed for the prevention of ocular disease, including those recommended by the Age-Related Eye Disease Studies (AREDS), when used in combination with conventional MVI/nutrient products was determined. Read More

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http://dx.doi.org/10.1016/j.japh.2019.01.013DOI Listing
April 2019
1 Read

Retinol isotope dilution accurately predicts liver reserves in piglets but overestimates reserves in lactating sows.

Exp Biol Med (Maywood) 2019 Mar 19:1535370219838785. Epub 2019 Mar 19.

Interdepartmental Graduate Program in Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.

Impact Statement: Vitamin A (VA) deficiency and hypervitaminosis A have been reported in groups of people worldwide. Conventional biomarkers of VA deficiency (e.g. Read More

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http://dx.doi.org/10.1177/1535370219838785DOI Listing
March 2019
3 Reads

Effects of vitamin A and vitamin E on attenuation of titanium dioxide nanoparticles-induced toxicity in the liver of male Wistar rats.

Mol Biol Rep 2019 Mar 18. Epub 2019 Mar 18.

School of Medicine, Hamadan University of Medical Sciences, Hamadan, 65178, Iran.

The increasing application of titanium dioxide nanoparticles (NTiO) in life and the toxicity potential of these nanoparticles have raised concerns about their detrimental effects on human health. This study was conducted to investigate the hepatoprotective effects of vitamin E and vitamin A against hepatotoxicity induced by NTiO in rats. Thirty-six male Wistar rats were randomly divided into six groups of six rats each. Read More

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http://link.springer.com/10.1007/s11033-019-04752-4
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http://dx.doi.org/10.1007/s11033-019-04752-4DOI Listing
March 2019
8 Reads

The synthetic retinoid ST1926 attenuates prostate cancer growth and potentially targets prostate cancer stem-like cells.

Mol Carcinog 2019 Mar 18. Epub 2019 Mar 18.

Department of Anatomy, Cell Biology, and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.

Retinoids are vitamin A derivatives that regulate crucial biological processes such as cellular proliferation, apoptosis, and differentiation. The use of natural retinoids in cancer therapy is limited due to their toxicity and the acquired resistance by cancer cells. Therefore, synthetic retinoids were developed, such as the atypical adamantyl retinoid ST1926 that provides enhanced bioavailability and reduced toxicity. Read More

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http://dx.doi.org/10.1002/mc.23004DOI Listing
March 2019
1 Read

Modulatory Role of Vitamins A and E on Memory and Motor Functions of Cyanide Induced Neurotoxicity in Adult Swiss Mice.

Niger J Physiol Sci 2018 Dec 30;33(2):183-189. Epub 2018 Dec 30.

Department of Nursing, College of Nursing and Midwifery Sciences, Sokoto.

Cyanide is a potent neurotoxic substance that can initiate series of intracellular reactions leading to oxidativestress. To evaluate effect of sublethal administration of potassium cyanide (KCN) on sensorimotor functions and long termvisuo-spatial learning and memory in adult Swiss mice and possible ameliorative role of vitamins A and E. These vitaminsA and E (dietary) are antioxidants that have scavenging properties against free radicals and reactive oxygen species as aresult of oxidative stress induced by cyanide. Read More

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December 2018
1 Read

The Wilms' tumor suppressor gene regulates pancreas homeostasis and repair.

PLoS Genet 2019 02 14;15(2):e1007971. Epub 2019 Feb 14.

Department of Animal Biology, Faculty of Science, University of Málaga, Málaga, Spain.

The Wilms' tumor suppressor gene (Wt1) encodes a zinc finger transcription factor that plays an essential role in the development of kidneys, gonads, spleen, adrenals and heart. Recent findings suggest that WT1 could also be playing physiological roles in adults. Systemic deletion of WT1 in mice provokes a severe deterioration of the exocrine pancreas, with mesothelial disruption, E-cadherin downregulation, disorganization of acinar architecture and accumulation of ascitic transudate. Read More

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http://dx.doi.org/10.1371/journal.pgen.1007971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392337PMC
February 2019

The effects of retinol oral supplementation in 6-hydroxydopamine dopaminergic denervation model in Wistar rats.

Neurochem Int 2019 May 7;125:25-34. Epub 2019 Feb 7.

Departamento de Bioquímica, Centro de Estudos em Estresse Oxidativo, Universidade Federal do Rio Grande do Sul-UFRGS, Brazil. Electronic address:

Vitamin A (retinol) is involved in signaling pathways regulating gene expression and was postulated to be a major antioxidant and anti-inflammatory compound of the diet. Parkinson's disease (PD) is a progressive neurodegenerative disorder, characterized by loss of nigral dopaminergic neurons, involving oxidative stress and pro-inflammatory activation. The aim of the present study was to evaluate the neuroprotective effects of retinol oral supplementation against 6-hydroxydopamine (6-OHDA, 12 μg per rat) nigrostriatal dopaminergic denervation in Wistar rats. Read More

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http://dx.doi.org/10.1016/j.neuint.2019.02.002DOI Listing
May 2019
2 Reads
3.092 Impact Factor

The retinoic acid receptor (RAR) in molluscs: Function, evolution and endocrine disruption insights.

Aquat Toxicol 2019 Mar 7;208:80-89. Epub 2019 Jan 7.

CIMAR/CIIMAR, Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Avenida General Norton de Matos s/n, 4450-208, Matosinhos, Portugal; FCUP - Department of Biology, Faculty of Sciences, University of Porto, Rua do Campo Alegre, 4169-007, Porto, Portugal. Electronic address:

Retinoid acid receptor (RAR)-dependent signalling pathways are essential for the regulation and maintenance of essential biological functions and are recognized targets of disruptive anthropogenic compounds. Recent studies put forward the inability of mollusc RARs to bind and respond to the canonical vertebrate ligand, retinoic acid: a feature that seems to have been lost during evolution. Yet, these studies were carried out in a limited number of molluscs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0166445X183064
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http://dx.doi.org/10.1016/j.aquatox.2019.01.002DOI Listing
March 2019
9 Reads

An Argument for Vitamin D, A, and Zinc Monitoring in Cirrhosis.

Ann Hepatol 2018 Oct;17(6):920-932

Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL, USA.

Malnutrition is prevalent in cirrhosis. Vitamin and mineral deficiencies, including vitamin D, vitamin A, and zinc, are common and have been shown to correlate with survival. Our aim was to review the mechanisms of vitamin D, vitamin A, and zinc deficiencies in cirrhosis and the clinical assessment of affected patients, their outcomes based on the current literature, and management. Read More

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https://annalsofhepatology.publisherspanel.com/gicid/01.3001
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http://dx.doi.org/10.5604/01.3001.0012.7192DOI Listing
October 2018
6 Reads

Latent role of in vitro Pb exposure in blocking Aβ clearance and triggering epigenetic modifications.

Environ Toxicol Pharmacol 2019 Feb 19;66:14-23. Epub 2018 Dec 19.

College of Public Health, Zhengzhou University, Zhengzhou, PR China. Electronic address:

Both β-amyloid (Aβ) catabolism and epigenetic regulation play critical roles in the onset of neurodegeneration. The latter also contribute to Pb neurotoxicity. The present study explored the role of epigenetic modifiers and Aβ degradation enzymes in Pb-induced latent effects on Aβ overproduction in vitro. Read More

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http://dx.doi.org/10.1016/j.etap.2018.12.015DOI Listing
February 2019
5 Reads

The need to consider context in the evaluation of anti-infectious and immunomodulatory effects of Vitamin A and its derivatives.

Curr Drug Targets 2018 Dec 16. Epub 2018 Dec 16.

FIOCRUZ, Rio de Janeiro. Brazil.

Vitamin A and its derivatives (retinoids) act as potent regulators in many aspects of mammalian reproduction, development, repair, and maintenance of differentiated tissue functioning. Unlike other vitamins, Vitamin A and retinoids, which have hormonal actions, present significant toxicity, which plays roles in clinically relevant situations, such as hypervitaminosis A and retinoic acid ("differentiation") syndrome. Although clinical presentation is conspicuous in states of insufficient or excessive Vitamin A and retinoid concentration, equally relevant effects on host resistance to specific infectious agents, and in the general maintenance of immune homeostasis, may go unnoticed, because their expression requires either pathogen exposure or the presence of inflammatory co-morbidities. Read More

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http://dx.doi.org/10.2174/1389450120666181217095323DOI Listing
December 2018
4 Reads

Supplementation of micronutrients in children and food fortification initiatives in Sri Lanka: benefits versus risks.

Ann N Y Acad Sci 2018 Nov 28. Epub 2018 Nov 28.

Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.

In recent decades, Sri Lanka has made substantial progress in reducing the burden of micronutrient deficiencies in children by the provision of vitamin A megadose and micronutrient supplementation programs for children of 6-23 months, along with universal iodization of salt. Consumption of voluntarily fortified foods by children was also considerably increased. The objective of our study here was to review such interventions, which are beneficial in childhood, and to assess the risk of toxicity due to excessive intakes of iron, vitamin A, and iodine. Read More

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http://doi.wiley.com/10.1111/nyas.13987
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http://dx.doi.org/10.1111/nyas.13987DOI Listing
November 2018
11 Reads

Aging and retinoid X receptor agonists on masculinization of female Pomacea canaliculata, with a critical appraisal of imposex evaluation in the Ampullariidae.

Ecotoxicol Environ Saf 2019 Mar 24;169:573-582. Epub 2018 Nov 24.

IHEM, Universidad Nacional de Cuyo, CONICET, Casilla de Correo 33, 5500-Mendoza, Argentina; Universidad Nacional de Cuyo, Facultad de Ciencias Médicas, Instituto de Fisiología, Casilla de Correo 33, 5500-Mendoza, Argentina; Universidad Nacional de Cuyo, Facultad de Ciencias Exactas y Naturales, Departamento de Biología, Casilla de Correo 33, 5500-Mendoza, Argentina.

Ampullariidae are unique among gastropods in that females normally show a primordium of the copulatory apparatus (CApp). The aims of this study were (a) to quantitatively evaluate the development and growth of the female CApp with age; (b) to compare the effects of RXR and PPARγ agonists in adult females of known age and (c) to explore the effect of masculinizing RXR agonists on the expression of RXR in the CApp. It was found that the CApp grows and develops with age. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01476513183110
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http://dx.doi.org/10.1016/j.ecoenv.2018.10.096DOI Listing
March 2019
4 Reads

Serum retinyl esters are positively correlated with analyzed total liver vitamin A reserves collected from US adults at time of death.

Am J Clin Nutr 2018 Nov;108(5):997-1005

Interdepartmental Graduate Program in Nutritional Sciences, University of Wisconsin-Madison, Madison, WI.

Background: Minimal human data exist on liver vitamin A (VA) compared with serum biomarkers. Cutoffs of 5% and 10% total serum VA as retinyl esters (REs) suggest a VA intoxication diagnosis.

Objectives: We compared total liver VA reserves (TLRs) with the percentage of total serum VA as REs to evaluate hypervitaminosis with the use of US adult autopsy samples. Read More

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/ajcn/nqy190DOI Listing
November 2018
11 Reads

Upregulation of transient receptor potential melastatin 6 channel expression by rosiglitazone and all-trans-retinoic acid in erlotinib-treated renal tubular epithelial cells.

J Cell Physiol 2019 Jun 21;234(6):8951-8962. Epub 2018 Nov 21.

Department of Biopharmaceutical Sciences, Laboratory of Biochemistry, Gifu Pharmaceutical University, Gifu, Japan.

Anti-epidermal growth factor receptor (EGFR) drugs including erlotinib cause a side effect of hypomagnesemia. In lung adenocarcinoma A549 cells, anticancer agents such as cisplatin and doxorubicin dose-dependently increased toxicity, but the effects were significantly suppressed by culturing the cells in low Mg -containing media. To obtain the maximum effect in cancer chemotherapy, it should be necessary to prevent the reduction of body Mg content. Read More

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http://dx.doi.org/10.1002/jcp.27565DOI Listing
June 2019
16 Reads

Alopecia and Associated Toxic Agents: A Systematic Review.

Skin Appendage Disord 2018 Oct 5;4(4):245-260. Epub 2018 Jan 5.

University of California, Irvine, Department of Dermatology, Irvine, California, USA.

Importance/objective: There are a number of toxic agents that can cause alopecia. In this review we summarize the known substances that cause alopecia as one of the clinical signs of overdose or toxicity.

Evidence Review: A search was conducted using PubMed, EMBASE, and Cochrane for studies describing hair loss of any type as a result of exposure to or ingestion of a toxic agent. Read More

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https://www.karger.com/Article/FullText/485749
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http://dx.doi.org/10.1159/000485749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219226PMC
October 2018
17 Reads

Identification of influential proteins in the classical retinoic acid signaling pathway.

Theor Biol Med Model 2018 10 16;15(1):16. Epub 2018 Oct 16.

Department of Mechanical Engineering, University of California Santa Barbara, Santa Barbara, CA, 93106, USA.

Background: In the classical pathway of retinoic acid (RA) mediated gene transcription, RA binds to a nuclear hormone receptor dimer composed of retinoic acid receptor (RAR) and retinoid X receptor (RXR), to induce the expression of its downstream target genes. In addition to nuclear receptors, there are other intracellular RA binding proteins such as cellular retinoic acid binding proteins (CRABP1 and CRABP2) and cytochrome P450 (CYP) enzymes, whose contributions to the RA signaling pathway have not been fully understood. The objective of this study was to compare the significance of various RA binding receptors, i. Read More

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https://tbiomed.biomedcentral.com/articles/10.1186/s12976-01
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http://dx.doi.org/10.1186/s12976-018-0088-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190658PMC
October 2018
18 Reads

Neurobehavioral and oxidative stress alterations following methylmercury and retinyl palmitate co-administration in pregnant and lactating rats and their offspring.

Neurotoxicology 2018 12 11;69:164-180. Epub 2018 Oct 11.

Centro de Estudos em Estresse Oxidativo, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2600 Anexo Dpto. Bioquímica, Laboratório 32, CEP 90035-003, Porto Alegre, Rio Grande do Sul, Brazil. Electronic address:

Fish consumption and ubiquitous methylmercury (MeHg) exposure represent a public health problem globally. Micronutrients presented in fish affects MeHg uptake/distribution. Vitamin A (VitA), another fish micronutrient is used in nutritional supplementation, especially during pregnancy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0161813X183019
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http://dx.doi.org/10.1016/j.neuro.2018.10.004DOI Listing
December 2018
4 Reads

Effect of molting on the concentration of plasma 25-hydroxyvitamin D in captive African penguins (Spheniscus demersus).

Comp Biochem Physiol A Mol Integr Physiol 2019 Jan 9;227:100-104. Epub 2018 Oct 9.

Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kitashirakawaoiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan. Electronic address:

Feed intake and body weight are drastically altered in penguins during peri-molting period, and molting is known to affect the nutritional status of vitamin A and E. Although vitamin D status is not known in penguins during peri-molting period, vitamin D intake is supposed to be remarkably altered. The objective of the present study was to clarify the alterations in plasma 25-hydroxyvitamin D (25(OH)D) concentration, the most reliable biomarker for assessing vitamin D status, and vitamin D intake during peri-molting period. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10956433183020
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http://dx.doi.org/10.1016/j.cbpa.2018.09.028DOI Listing
January 2019
6 Reads

RNA-sequencing to assess the health of wild yellow perch (Perca flavescens) populations from the St. Lawrence River, Canada.

Environ Pollut 2018 Dec 30;243(Pt B):1657-1668. Epub 2018 Sep 30.

Environment and Climate Change Canada, 105 McGill Street, Montréal, QC, H2Y 2E7, Canada.

This study aimed to better understand in situ cumulative effects of anthropogenic stressors on the health of St. Lawrence River (QC, Canada) yellow perch populations using high-throughput transcriptomics and a multi-biological level approach. Fish were collected in the upstream fluvial Lake Saint-François (LSF) with low degree of environmental perturbations; Lake Saint-Louis (LSL) considered having a moderate degree of anthropogenic stressors, and Lake Saint-Pierre (LSP) a sector where the perch population has been severely declining. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02697491183172
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http://dx.doi.org/10.1016/j.envpol.2018.09.133DOI Listing
December 2018
16 Reads

Inhibition of NRF2 signaling and increased reactive oxygen species during embryogenesis in a rat model of retinoic acid-induced neural tube defects.

Neurotoxicology 2018 12 26;69:84-92. Epub 2018 Sep 26.

Key Laboratory of Health Ministry for Congenital Malformation, Shengjing Hospital, China Medical University, Shenyang, PR China. Electronic address:

Exposure to retinoic acid (RA) during pregnancy increases the risk of serious neural tube defects (NTDs) in the developing fetus. The precise molecular mechanism for this process is unclear; however, RA is associated with oxidative stress mediated by reactive oxygen species. Nuclear factor erythroid 2-related factor 2 (NRF2) is a master regulator of oxidative stress that directs the expression of antioxidant genes and detoxifying proteins to maintain redox homeostasis. Read More

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http://dx.doi.org/10.1016/j.neuro.2018.09.005DOI Listing
December 2018
10 Reads

Poor Vitamin Status is Associated with Skeletal Muscle Loss and Mucositis in Head and Neck Cancer Patients.

Nutrients 2018 Sep 5;10(9). Epub 2018 Sep 5.

Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2E1, Canada.

Mucositis and muscle wasting are two common toxicity effects of cancer treatment in head and neck cancer (HNC). There is limited data evaluating cancer treatment toxicities in relation to vitamin status. This study aimed to assess changes in vitamin status during HNC treatment in relation to body composition, inflammation and mucositis. Read More

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http://www.mdpi.com/2072-6643/10/9/1236
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http://dx.doi.org/10.3390/nu10091236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165496PMC
September 2018
9 Reads

Effect of vitamin A and vitamin C on attenuation of ivermectin-induced toxicity in male Wistar rats.

Environ Sci Pollut Res Int 2018 Oct 20;25(29):29408-29417. Epub 2018 Aug 20.

School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.

An in vivo study was performed to assay the effects of ivermectin on adult male Wistar rats. Twenty-five male Wistar rats aged 6 to 8 weeks and weighing 150-250 g were divided into five groups of five animals each for the purpose of this study. The groups received ivermectin; a mixture of ivermectin and vitamin A; a mixture of ivermectin and vitamin C; and a mixture of ivermectin, vitamin A, and vitamin C, respectively. Read More

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http://dx.doi.org/10.1007/s11356-018-2961-7DOI Listing
October 2018
13 Reads

Vitamin A and beta (β)-carotene supplementation for cystic fibrosis.

Cochrane Database Syst Rev 2018 08 9;8:CD006751. Epub 2018 Aug 9.

Faculty of Medical Sciences, University of Groningen, A. Deusinglaan 1, Groningen, Netherlands, 9713 AV.

Background: People with cystic fibrosis (CF) and pancreatic insufficiency are at risk of a deficiency in fat-soluble vitamins, including vitamin A. Vitamin A deficiency predominantly causes eye and skin problems, while excessive levels of vitamin A can harm the respiratory and skeletal systems in children and interfere with the metabolism of other fat-soluble vitamins. Most CF centres administer vitamin A as supplements to reduce the frequency of vitamin A deficiency in people with CF and to improve clinical outcomes such as growth, although the recommended dose varies between different guidelines. Read More

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http://doi.wiley.com/10.1002/14651858.CD006751.pub5
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http://dx.doi.org/10.1002/14651858.CD006751.pub5DOI Listing
August 2018
10 Reads

Effects of all-trans retinoic acid (ATRA) in addition to chemotherapy for adults with acute myeloid leukaemia (AML) (non-acute promyelocytic leukaemia (non-APL)).

Cochrane Database Syst Rev 2018 08 6;8:CD011960. Epub 2018 Aug 6.

Cochrane Haematological Malignancies Group, Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.

Background: Acute myeloid leukaemia (AML) is the most common acute leukaemia affecting adults. Most patients diagnosed with AML are at advanced age and present with co-morbidities, so that intensive therapy such as stem cell transplantation (SCT) is impossible to provide or is accompanied by high risks for serious adverse events and treatment-related mortality. Especially for these patients, it is necessary to find out whether all-trans retinoic acid (ATRA), an intermediate of vitamin A inducing terminal differentiation of leukaemic cell lines, added to chemotherapy confers increased benefit or harm when compared with the same chemotherapy alone. Read More

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http://dx.doi.org/10.1002/14651858.CD011960.pub2DOI Listing
August 2018
3 Reads

Zedoarondiol Attenuates Endothelial Cells Injury Induced by Oxidized Low-Density Lipoprotein via Nrf2 Activation.

Cell Physiol Biochem 2018 31;48(4):1468-1479. Epub 2018 Jul 31.

Cardiovascular Disease Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Background/aims: Zedoarondiol, a sesquiterpene lactone compound, showed an anti-proliferative activity on vascular smooth muscle cells in our previous study. However, whether it has a beneficial effect on endothelial cells injury induced by oxidized low-density lipoprotein (ox-LDL) remains unclear. This study was designed to investigate the protective effect of zedoarondiol on ox-LDL-induced injury of endothelial cells and explored its underlying mechanism. Read More

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http://dx.doi.org/10.1159/000492257DOI Listing
September 2018
4 Reads

Effects of methylmercury and retinol palmitate co-administration in rats during pregnancy and breastfeeding: Metabolic and redox parameters in dams and their offspring.

Ecotoxicol Environ Saf 2018 Oct;162:603-615

Centro de Estudos em Estresse Oxidativo, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2600, Anexo Depto. Bioquímica, Lab 32, CEP 90035-003 Porto Alegre, Rio Grande do Sul, Brazil; Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil. Electronic address:

Ubiquitous low-dose methylmercury (MeHg) exposure through an increased fish consumption represents a global public health problem, especially among pregnant women. A plethora of micronutrients presented in fish affects MeHg uptake/distribution, but limited data is available. Vitamin A (VitA), another fish micronutrient is used in nutritional supplementation, especially during pregnancy. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2018.06.093DOI Listing
October 2018
9 Reads

All Trans Retinoic Acid Attenuates Markers of Neuroinflammation in Rat Brain by Modulation of SIRT1 and NFκB.

Neurochem Res 2018 Sep 18;43(9):1791-1801. Epub 2018 Jul 18.

Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram, 695 581, Kerala, India.

Alcohol abuse affects several neurological pathways and causes significant alterations in the brain. Abstention from alcohol causes only a marginal decrease in oxidative stress and neuro inflammation. Our previous studies had shown that an active metabolite of vitamin A, all trans retinoic acid (ATRA), ameliorates alcohol induced toxicity. Read More

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http://dx.doi.org/10.1007/s11064-018-2595-7DOI Listing
September 2018
2 Reads

Time to revisit the strategy of massive vitamin A prophylaxis dose administration to the under five children in India - An analysis of available evidence.

Clin Nutr ESPEN 2017 10 19;21:26-30. Epub 2017 Jul 19.

School of Public Health, Department of Community Medicine, Postgraduate Institute of Medical Education & Research, India.

Childhood blindness due to corneal ulceration has historically been prevalent among poor Indian children. To tackle this situation the National Institute of Nutrition (NIN), Hyderabad, India, launched (after field-testing) massive dose based national vitamin A (Vit-A) prophylaxis program. Over a period of time reduction in childhood mortality was also hailed as a beneficial effect of the program. Read More

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http://dx.doi.org/10.1016/j.clnesp.2017.07.001DOI Listing
October 2017
6 Reads

Temporal variations in kidney metal concentrations and their implications for retinoid metabolism and oxidative stress response in wild yellow perch (Perca flavescens).

Aquat Toxicol 2018 Sep 9;202:26-35. Epub 2018 Jun 9.

Institut national de la Recherche scientifique (INRS), Centre Eau Terre Environnement, 490 de la Couronne, Québec, QC, G1K 9A9, Canada. Electronic address:

The objective of this study was to determine if temporal variations in tissue metal concentrations are related to biomarkers of retinoid metabolism and oxidative stress responses in juvenile yellow perch (Perca flavescens). To this end, kidney metal (Cd, Cu and Zn) concentrations were measured in fish sampled in spring and fall 2012 in four lakes representing a wide range of water and sediment metal contamination in the Rouyn-Noranda (Quebec) region. Lakes Opasatica and Hélène were considered as reference lakes while lakes Dufault and Marlon were metal-contaminated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0166445X183035
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http://dx.doi.org/10.1016/j.aquatox.2018.06.007DOI Listing
September 2018
13 Reads

Salinomycin induces apoptosis and differentiation in human acute promyelocytic leukemia cells.

Oncol Rep 2018 Aug 20;40(2):877-886. Epub 2018 Jun 20.

Central Laboratory of Yongchuan Hospital, Chongqing Medical University, Chongqing 402160, P.R. China.

At present, acute promyelocytic leukemia (APL) is the most curable form of acute myeloid leukemia and can be treated using all-trans retinoic acid and arsenic trioxide. However, the current treatment of APL is associated with some issues such as drug toxicity, resistance and relapse. Therefore, other strategies are necessary for APL treatment. Read More

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http://dx.doi.org/10.3892/or.2018.6513DOI Listing
August 2018
16 Reads

SC1 inhibits the differentiation of F9 embryonic carcinoma cells induced by retinoic acid.

Acta Biochim Biophys Sin (Shanghai) 2018 Aug;50(8):793-799

College of Veterinary Medicine, Northwest A&F University, Yangling, China.

The ability to self-renew is one of the most important properties of embryonic stem (ES) cells. Pluripotin (SC1), a small molecule with high activity and low toxicity, promotes self-renewal in mouse ES cells. SC1 can noticeably change the morphology of retinoic acid (RA)-induced F9 embryonic carcinoma cells (F9 cells). Read More

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http://dx.doi.org/10.1093/abbs/gmy069DOI Listing
August 2018
3 Reads

Desmoglein1 Deficiency Is a Potential Cause of Cutaneous Eruptions Induced by Shuanghuanglian Injection.

Molecules 2018 Jun 19;23(6). Epub 2018 Jun 19.

Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.

Cutaneous eruption is a common drug-adverse reaction, characterised by keratinocytes inflammation and apoptosis. Shuanghuanglian injeciton (SHLI) is a typical Chinese medicine injection, which is used to treat influenza. It has been reported that SHLI has the potential to induce cutaneous adverse eruptions. Read More

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http://dx.doi.org/10.3390/molecules23061477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099613PMC
June 2018
23 Reads

β-apo-10'-carotenoids support normal embryonic development during vitamin A deficiency.

Sci Rep 2018 Jun 11;8(1):8834. Epub 2018 Jun 11.

Department of Food Science, Rutgers Center for Lipid Research, and New Jersey Institute for Food, Nutrition, and Health, Rutgers University, New Brunswick, New Jersey, 08901, United States.

Vitamin A deficiency is still a public health concern affecting millions of pregnant women and children. Retinoic acid, the active form of vitamin A, is critical for proper mammalian embryonic development. Embryos can generate retinoic acid from maternal circulating β-carotene upon oxidation of retinaldehyde produced via the symmetric cleavage enzyme β-carotene 15,15'-oxygenase (BCO1). Read More

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http://dx.doi.org/10.1038/s41598-018-27071-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995931PMC
June 2018
15 Reads

Vitamin A-decorated biocompatible micelles for chemogene therapy of liver fibrosis.

J Control Release 2018 Aug 29;283:113-125. Epub 2018 May 29.

State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China; Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, China Pharmaceutical University, Nanjing 210009, China; Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China; Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, China Pharmaceutical University, Nanjing 210009, China. Electronic address:

Liver fibrosis refers to excessive accumulation of hepatic collagen, which is primarily produced by activated hepatic stellate cells (HSCs). No effective drugs are clinically available to treat this condition, reflecting the fact that antifibrotic drugs do not specifically target activated HSCs. Here, we report the synthesis and evaluation of poly (lactide-co-glycolide)-polyspermine-poly (ethylene glycol)-vitamin A (PLGA-PSPE-PEG-VA), and activated HSC-targeted, biocompatible amphiphilic polymers for co-delivery of chemical (silibinin) and genetic (siCol1α1) drugs that synergistically suppress collagen I accumulation in fibrogenesis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01683659183031
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http://dx.doi.org/10.1016/j.jconrel.2018.05.032DOI Listing
August 2018
9 Reads

Pseudotumor Cerebri Syndrome with Resolution After Discontinuing High Vitamin A Containing Dietary Supplement: Case Report and Review.

Neuroophthalmology 2018 Jun 1;42(3):169-175. Epub 2017 Sep 1.

Department of Neurology, University of Kentucky, Lexington, Kentucky, USA.

A 24-year-old non-obese, but slightly overweight, female presented with a two-week history of progressive severe headache associated with two days of blurry vision. Clinical exam was significant for bilateral papilledema and an enlarged blind spot on visual field testing. Contrast enhanced MRI head revealed no space occupying lesion. Read More

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http://dx.doi.org/10.1080/01658107.2017.1367931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958954PMC
June 2018
3 Reads

Liver transplantation for very severe hepatopulmonary syndrome due to vitamin A-induced chronic liver disease in a patient with Shwachman-Diamond syndrome.

Orphanet J Rare Dis 2018 05 2;13(1):69. Epub 2018 May 2.

Laboratory of Inborn Errors of Immunity, Department of Microbiology and Immunology, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.

Vitamin A intoxication is a rare cause of liver disease, but the risk increases in patients with underlying liver dysfunction. We present a patient with Shwachman-Diamond Syndrome who developed liver fibrosis, portal hypertension and very severe hepatopulmonary syndrome as a consequence of chronic vitamin A intoxication. She underwent successful liver transplantation with complete resolution of the pulmonary shunting. Read More

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http://dx.doi.org/10.1186/s13023-018-0818-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930429PMC
May 2018
6 Reads

Effects of co-exposure to lead and zinc on redox status, kidney variables, and histopathology in adult albino rats.

Toxicol Ind Health 2018 Jul 27;34(7):469-480. Epub 2018 Apr 27.

Laboratory of Animal Ecophysiology, Faculty of Sciences, University of Sfax, Sfax, Tunisia.

Lead (Pb) is a toxic metal that induces a wide range of biochemical and physiological effects in humans. Oxidative damage has been proposed as a possible mechanism involved in Pb toxicity. The current study was carried out to evaluate the antioxidant activities of zinc (Zn) supplement against lead acetate-induced kidney injury in rats. Read More

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http://dx.doi.org/10.1177/0748233718770293DOI Listing
July 2018
17 Reads

Studies of indirect and direct effects of hypervitaminosis A on rat bone by comparing free access to food and pair-feeding.

Ups J Med Sci 2018 Jun 26;123(2):82-85. Epub 2018 Apr 26.

a Department of Medical Sciences , Section of Clinical Pharmacology, Uppsala University , Uppsala , Sweden.

Background: The most prominent features of hypervitaminosis A in rats are spontaneous fractures and anorexia. Since caloric restriction induces alterations in bone, some effects could be secondary to loss of appetite. To clarify the mechanisms behind vitamin A-induced bone fragility it is necessary to distinguish between direct and indirect effects. Read More

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http://dx.doi.org/10.1080/03009734.2018.1448020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055747PMC
June 2018
1 Read

Toxicogenetic study of omeprazole and the modulatory effects of retinol palmitate and ascorbic acid on Allium cepa.

Chemosphere 2018 08 5;204:220-226. Epub 2018 Apr 5.

Laboratory of Genetics and Toxicology (LAPGENIC), Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil.

Omeprazole (OME) is a proton pump inhibitor used for the treatment of various gastric and intestinal disease; however, studies on its effects on the genetic materials are still restricted. The present study aimed to evaluate possible toxicogenic effects of OME in Allium cepa meristems with the application of cytogenetic biomarkers for DNA damage, mutagenic, toxic and cytotoxic effects. Additionally, retinol palmitate (RP) and ascorbic acid (AA) were also co-treated with OME to evaluate possible modulatory effects of OME-induced cytogenetic damages. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.04.021DOI Listing
August 2018
31 Reads

Inhibition of cancer stem cell like cells by a synthetic retinoid.

Nat Commun 2018 04 11;9(1):1406. Epub 2018 Apr 11.

State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.

Developing novel drugs that can abrogate the growth and metastasis of malignant tumors is a major challenge for cancer researchers. Here we describe a novel synthetic retinoid, namely WYC-209, which inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs), known to resist conventional drug treatment, with an IC of 0.19 μM in a dose-dependent manner. Read More

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http://dx.doi.org/10.1038/s41467-018-03877-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895803PMC
April 2018
6 Reads

ATRA attenuate proteinuria via downregulation of TRPC6 in glomerulosclerosis rats induced by adriamycin.

Ren Fail 2018 Nov;40(1):266-272

a Department of Pediatric Nephrology , The First Affiliated Hospital of GuangXi Medical University , Nanning , China.

Objective: In this research, we explored the molecular mechanism of proteinuria in glomerulosclerosis rats and the protective effects of ATRA.

Methods: This research set up three groups: SHO group, GS group, and ATRA group (15 mg/(kg d), Sigma, St. Louis, MO). Read More

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http://dx.doi.org/10.1080/0886022X.2018.1456459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014515PMC
November 2018
12 Reads

Role of cytarabine in paediatric acute promyelocytic leukemia treated with the combination of all-trans retinoic acid and arsenic trioxide: a randomized controlled trial.

BMC Cancer 2018 04 3;18(1):374. Epub 2018 Apr 3.

State Key Laboratory of Experimental Hematology, Department of Paediatrics Haematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin, 300020, People's Republic of China.

Background: The combination of all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) has been suggested to be safe and effective for adult acute promyelocytic leukaemia (APL). As of 2010, the role of cytarabine (Ara-C) in APL was controversial. The aim of this study was to test the efficacy and safety of ATRA and ATO in paediatric APL patients. Read More

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http://dx.doi.org/10.1186/s12885-018-4280-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883545PMC
April 2018
14 Reads

Encapsulation and controlled release of retinol from silicone particles for topical delivery.

J Control Release 2018 05 28;278:37-48. Epub 2018 Mar 28.

NSF Research Triangle Materials Research Science and Engineering Center, Duke University, Durham, NC 27708, USA; Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA; Department of Chemistry, Duke University, Durham, NC 27708, USA. Electronic address:

Retinol, a derivative of vitamin A, is a ubiquitous compound used to treat acne, reduce wrinkles and protect against conditions like psoriasis and ichthyosis. While retinol is used as the primary active ingredient (AI) in many skin care formulations, its efficacy is often limited by an extreme sensitivity to degrade and toxicity at high concentrations. While microencapsulation is an appealing method to help overcome these issues, few microencapsulation strategies have made a major translational impact due to challenges with complexity, cost, limited protection of the AI and poor control of the release of the AI. Read More

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http://dx.doi.org/10.1016/j.jconrel.2018.03.023DOI Listing
May 2018
8 Reads

Vitamin A Supplementation by Endotracheal Application of a Nano-encapsulated Preparation Is Feasible in Ventilated Preterm Lambs.

J Aerosol Med Pulm Drug Deliv 2018 12 27;31(6):323-330. Epub 2018 Mar 27.

2 Department of Pediatrics, Maastricht University Medical Center , Faculty of Health, Medicine and Lifesciences, School for Oncology and Developmental Biology (GROW), Maastricht, The Netherlands .

Background: Vitamin A (VA) is crucial for lung growth and development. In premature infants, inadequate VA levels are associated with an increased risk of bronchopulmonary dysplasia (BPD). Intramuscular VA supplementation has been shown to decrease the incidence of BPD, but is not widely used in the clinical setting due to concerns about feasibility and pain. Read More

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http://dx.doi.org/10.1089/jamp.2017.1438DOI Listing
December 2018
15 Reads

Selenium and zinc: Two key players against cadmium-induced neuronal toxicity.

Toxicol In Vitro 2018 Apr;48:159-169

Department of Experimental and Clinical Medicine, Histology and Anatomy Section, University of Firenze, Firenze, Italy.

Cadmium (Cd), a worldwide occupational pollutant, is an extremely toxic heavy metal, capable of damaging several organs, including the brain. Its toxicity has been related to neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. The neurotoxic potential of Cd has been attributed to the changes induced in the brain enzyme network involved in counteracting oxidative stress. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08872333183000
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http://dx.doi.org/10.1016/j.tiv.2018.01.007DOI Listing
April 2018
7 Reads

Building a developmental toxicity ontology.

Birth Defects Res 2018 04 31;110(6):502-518. Epub 2018 Jan 31.

Central Product Safety Department, The Procter & Gamble Company, Mason, Ohio.

Background: As more information is generated about modes of action for developmental toxicity and more data are generated using high-throughput and high-content technologies, it is becoming necessary to organize that information. This report discussed the need for a systematic representation of knowledge about developmental toxicity (i.e. Read More

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http://dx.doi.org/10.1002/bdr2.1189DOI Listing
April 2018
5 Reads

A Possible Link Between Pyriproxyfen and Microcephaly.

PLoS Curr 2017 Nov 27;9. Epub 2017 Nov 27.

Department of Complex Systems, New England Complex Systems Institute, Cambridge, MA, USA.

The Zika virus has been the primary suspect in the large increase in incidence of microcephaly in 2015-6 in Brazil. While evidence for Zika being the cause of some of the cases is strong, its role as the primary cause of the large number of cases in Brazil has not been confirmed. Recently, the disparity between the incidences in different geographic locations has led to questions about the virus's role. Read More

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http://dx.doi.org/10.1371/currents.outbreaks.5afb0bfb8cf31d9a4baba7b19b4edbacDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760164PMC
November 2017
3 Reads