Genes Nutr 2016 17;11. Epub 2016 Mar 17.
Postgraduate Program in Human Nutrition, Faculty of Health Sciences, University of Brasília, Campus Universitário Darcy Ribeiro, POBox 70910-900, Brasília, DF Brazil ; Instituto de Ciências Biológicas, Departamento de Biologia Celular, Laboratório de Bioquímica da Nutrição, Universidade de Brasília, Campus Universitário Darcy Ribeiro, Bloco J, 1 Andar. Asa Norte, Brasília, Distrito Federal CEP: 70910-900 Brasil.
: Considering that vitamin A deficiency modulates hepcidin expression and consequently affects iron metabolism, we evaluated the effect of vitamin A deficiency in the expression of genes involved in the hemojuvelin (HJV)-bone morphogenetic protein 6 (BMP6)-small mothers against decapentaplegic protein (SMAD) signaling pathway.Methods
: Male Wistar rats were treated: control AIN-93G diet (CT), vitamin A-deficient diet (VAD), iron-deficient diet (FeD), vitamin A- and iron-deficient diet (VAFeD), or 12 mg all-trans retinoic acid (atRA)/kg diet.Results
: Vitamin A deficiency (VAD) increased hepatic Bmp6 and Hfe2 mRNA levels and down-regulated hepatic Hamp, Smad7, Rarα, and intestinal Fpn1 mRNA levels compared with the control. Read More