6,668 results match your criteria Vitamin A Deficiency


Provitamin A Carotenoids in Grain Reduce Aflatoxin Contamination of Maize While Combating Vitamin A Deficiency.

Front Plant Sci 2019 29;10:30. Epub 2019 Jan 29.

International Maize and Wheat Improvement Center, Texcoco, Mexico.

Aflatoxin contamination of maize grain and products causes serious health problems for consumers worldwide, and especially in low- and middle-income countries where monitoring and safety standards are inconsistently implemented. Vitamin A deficiency (VAD) also compromises the health of millions of maize consumers in several regions of the world including large parts of sub-Saharan Africa. We investigated whether provitamin A (proVA) enriched maize can simultaneously contribute to alleviate both of these health concerns. Read More

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http://dx.doi.org/10.3389/fpls.2019.00030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369730PMC
January 2019

Prevalence of ocular morbidity among tribal children in Jawadhi hills, southern India: A cross-sectional study.

Indian J Ophthalmol 2019 Mar;67(3):386-390

Department of Ophthalmology, Schell Eye Hospital, Christian Medical College, Vellore, Tamil Nadu, India.

Purpose: Childhood blindness is second to cataract in terms of blind person years; population-based prevalence of ocular morbidity among tribal children has not been studied. We conducted this study to determine the prevalence of ocular morbidity in tribal children age 15 years or younger in Jawadhi hills, southern India.

Methods: A population-based cross-sectional study was conducted in four tribal villages where all children below 15 years of age were invited to participate in the study. Read More

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http://dx.doi.org/10.4103/ijo.IJO_795_18DOI Listing

Assessment of Vitamin Status in Patients with Nontuberculous Mycobacterial Pulmonary Disease: Potential Role of Vitamin A as a Risk Factor.

Nutrients 2019 Feb 5;11(2). Epub 2019 Feb 5.

Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea.

As microbiological diagnostic techniques improve and the frequency of nontuberculous mycobacterial pulmonary disease (NTM-PD) infection increases worldwide, NTM-PD is becoming increasingly important to clinicians and researchers. Vitamin activity has been associated with the host immune response in tuberculosis; however, such information is very limited in NTM-PD. We performed a case-control study in 150 patients with NTM-PD and 150 healthy controls to investigate serum vitamin status. Read More

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http://dx.doi.org/10.3390/nu11020343DOI Listing
February 2019
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Rethinking integrated nutrition-health strategies to address micronutrient deficiencies in children under five in Mozambique.

Matern Child Nutr 2019 Jan;15 Suppl 1:e12721

USAID's Maternal and Child Survival Program (MCSP)/PATH, Washington, District of Columbia, USA.

In Mozambique, about two thirds of children 6-59 months of age are affected by vitamin A deficiency and anaemia. The objective of this case study is to provide programme considerations for planning, implementing, monitoring, and evaluating vitamin A and iron deficiency interventions within the context of lessons learned to date for vitamin A supplementation, micronutrient powders (MNPs), and food-based strategies. For 15 years, the Mozambique Ministry of Health implemented twice-yearly vitamin A supplementation through both campaigns and routine health services. Read More

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http://dx.doi.org/10.1111/mcn.12721DOI Listing
January 2019
1 Read

Retinyl esters are elevated in progeny of retinol dehydrogenase 11 deficient dams.

Chem Biol Interact 2019 Feb 4. Epub 2019 Feb 4.

Department of Biochemistry and Molecular Genetics, Schools of Medicine and Dentistry, University of Alabama at Birmingham, Birmingham, AL, 35294, USA. Electronic address:

Retinol dehydrogenase 11 (RDH11) is an NADPH-dependent retinaldehyde reductase that was previously reported to function in the visual cycle. Recently, we have shown that RDH11 contributes to the maintenance of retinol levels in extraocular tissues under conditions of vitamin A deficiency or reduced vitamin A availability. RDH11 is also expressed in the embryo. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.01.041DOI Listing
February 2019
1 Read

Lycopene cyclases determine high α-/β-carotene ratio and increased carotenoids in bananas ripening at high temperatures.

Food Chem 2019 Jun 14;283:131-140. Epub 2019 Jan 14.

Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement & Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Xingke Road 723, Tianhe District, Guangzhou 510650, China; College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China. Electronic address:

Bananas are a recommended food source to alleviate vitamin A deficiency because they contain a high ratio of provitamin A precursors. The objective of this study was to investigate carotenoid accumulation pattern in banana fruits during postharvest ripening and the mechanisms regulating this process. Ripe banana pulp had an unusually high α-/β-carotene ratio (1. Read More

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http://dx.doi.org/10.1016/j.foodchem.2018.12.121DOI Listing
June 2019
1 Read

Vitamin A deficiency impairs intestinal physical barrier function of fish.

Fish Shellfish Immunol 2019 Feb 1;87:546-558. Epub 2019 Feb 1.

Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Chengdu, 611130, China. Electronic address:

The present study was the first to investigate the effects of dietary vitamin A (VA) on the intestinal physical barrier function associated with oxidation, antioxidant system, apoptosis and cell-cellular tight junction (TJ) in the proximal (PI), mid (MI) and distal (DI) intestines of young grass carp (Ctenopharyngodon idella). Fish were fed graded levels of dietary VA for 10 weeks, and then a challenge test using an injection of Aeromonas hydrophila was conducted for 14 days. Results indicated that dietary VA deficiency caused oxidative damage to fish intestine partly by the reduced non-enzymatic antioxidant components glutathione (GSH) and VA contents as well as reduced antioxidant enzyme activities [not including manganese superoxide dismutase (MnSOD)]. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10504648193007
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http://dx.doi.org/10.1016/j.fsi.2019.01.056DOI Listing
February 2019
2 Reads

Driving Policy Change to Improve Micronutrient Status in Women of Reproductive Age and Children in Southeast Asia: The SMILING Project.

Matern Child Health J 2019 Jan;23(Suppl 1):79-85

Institute of Research for Development (IRD), UMR 204 Nutripass IRD/UM/SupAgro, Montpellier, France.

Objective The SMILING (Sustainable Micronutrient Interventions to Control Deficiencies and Improve Nutritional Status and General Health in Asia) project aimed at creating awareness and improving policies around micronutrient deficiencies in five Southeast Asian countries (Vietnam, Laos, Thailand, Cambodia and Indonesia). Results The project showed large gaps in recent data on micronutrient status in most of the five countries. By updating existing, or creating national food composition tables, the SMILING project enabled analyses of food consumption in women of reproductive age and young children. Read More

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http://dx.doi.org/10.1007/s10995-018-02730-zDOI Listing
January 2019
2 Reads

Effects of AM80 compared to AC261066 in a high fat diet mouse model of liver disease.

PLoS One 2019 24;14(1):e0211071. Epub 2019 Jan 24.

Department of Pharmacology, Weill Cornell Medicine, New York, NY, United States of America.

The roles of retinoids in nonalcoholic fatty liver disease (NAFLD) remain unclear and a better understanding may lead to therapies that prevent or limit NAFLD progression. We examined the actions of retinoic acid receptor (RAR) agonists- AM80 for RARα and AC261066 for RARβ2- in a murine model of NAFLD. We fed wild type C57Bl/6 mice a chow or a 45% high fat diet (HFD) for 12 weeks, followed by 4 additional weeks with the HFD+AM80; HFD+AC261066; or HFD. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211071PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345457PMC
January 2019
3 Reads

Retinoic Acid Mediated Clearance of in Vitamin A Deficient Mice Requires CD11b+ and T Cells.

Front Immunol 2018 8;9:3090. Epub 2019 Jan 8.

Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, United States.

Vitamin A deficiency affects over 250 million preschool-age children worldwide and is associated with increased childhood mortality and risk of developing enteric infections. Vitamin A deficient (A-) mice developed chronic infection. A single oral dose of retinoic acid (RA) at d7 post-infection was sufficient to induce clearance of the pathogen in A- mice. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2018.03090
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http://dx.doi.org/10.3389/fimmu.2018.03090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331472PMC
January 2019
5 Reads

Micronutrient status of Indian population.

Indian J Med Res 2018 Nov;148(5):511-521

Centre for Promotion of Nutrition Research and Training with Special Focus on North East, Tribal & Inaccessible Population, Division of Nutrition, Indian Council of Medical Research (Campus II), Tuberculosis Association of India Building, New Delhi; ICMR-Desert Medicine Research Centre, Jodhpur, India.

Micronutrients play an important role in the proper growth and development of the human body and its deficiency affects the health contributing to low productivity and vicious cycle of malnutrition, underdevelopment as well as poverty. Micronutrient deficiency is a public health problem affecting more than one-fourth of the global population. Several programmes have been launched over the years in India to improve nutrition and health status of the population; however, a large portion of the population is still affected by micronutrient deficiency. Read More

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http://dx.doi.org/10.4103/ijmr.IJMR_1768_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366258PMC
November 2018
1 Read

National control programme against nutritional blindness due to vitamin A deficiency: Current status & future strategy.

Authors:
K Vijayaraghavan

Indian J Med Res 2018 Nov;148(5):496-502

National Institute of Nutrition, Hyderabad, India.

Vitamin A deficiency (VAD) among 1-5 yr old children is reported to be widely prevalent in Southeast Asia and some parts of Africa. It is the leading cause of preventable blindness in young children in the low-income countries in the world. Children even with milder signs of VAD have higher risk of morbidity and mortality. Read More

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http://www.ijmr.org.in/text.asp?2018/148/5/496/249982
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http://dx.doi.org/10.4103/ijmr.IJMR_1781_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366267PMC
November 2018
4 Reads

Melatonin protected against the detrimental effects of microRNA-363 in a rat model of vitamin A-associated congenital spinal deformities: Involvement of Notch signaling.

J Pineal Res 2019 Jan 17:e12558. Epub 2019 Jan 17.

Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Congenital spinal deformities are a result of defective somitogenesis and are associated with vitamin A deficiency (VAD). However, the molecular mechanisms of VAD-associated congenital spinal deformities remain largely unknown. Increasing number of studies suggested that microRNAs and melatonin played important roles in the development of congenital spinal deformities. Read More

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http://dx.doi.org/10.1111/jpi.12558DOI Listing
January 2019
1 Read

Vitamin A deficiency and associated factors in preschoolers from the outskirts of La Plata, Buenos Aires.

Arch Argent Pediatr 2019 02;117(1):19-25

Instituto de Desarrollo e Investigaciones Pediátricas (IDIP) "Prof. Dr. Fernando E. Viteri", Hospital de Niños "Sor María Ludovica", La Plata, Buenos Aires.

Introduction: Vitamin A deficiency (VAD) has been recognized as an important public health problem in developing countries. Preschoolers account for risk groups within vulnerable populations. The objective of this study was to determine the prevalence of VAD and associated factors in a sample of preschoolers. Read More

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http://dx.doi.org/10.5546/aap.2019.eng.19DOI Listing
February 2019
3 Reads

Evaluation of Agronomic Performance of β-Carotene Elevated Sorghum in Confined Field Conditions.

Methods Mol Biol 2019 ;1931:209-220

Corteva Agriscience™, Agriculture Division of DowDuPont™, Johnston, IA, USA.

To help alleviate vitamin A deficiency in Africa, we have developed nutritionally enhanced sorghum with stabilized high all-trans-β-carotene accumulation. Toward the finalization of this nutritionally enhanced sorghum for food production, confined field trials were conducted to determine the agronomic performance of thirteen independent transgenic events in Iowa and Hawaii. Through these trials, three leading events with no negative impact on agronomic performance were identified. Read More

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http://dx.doi.org/10.1007/978-1-4939-9039-9_15DOI Listing
January 2019
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Impact of the Nutrition-Friendly School Initiative: analysis of anthropometric and biochemical data among school-aged children in Ouagadougou.

Glob Health Promot 2019 Jan 16:1757975918789350. Epub 2019 Jan 16.

2 University of Montreal, Montreal, Quebec, Canada.

The Nutrition-Friendly School Initiative was developed in 2006 to counter the double burden of malnutrition and implemented on a pilot basis in primary schools in Ouagadougou (Burkina Faso) in 2009. A baseline study was conducted in intervention and control schools and repeated in 2014 to assess the impact. This paper reports on anthropometric and biochemical data in the final and baseline surveys. Read More

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http://dx.doi.org/10.1177/1757975918789350DOI Listing
January 2019
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Effect of vitamin A deficiency on thymosin-β4 and CD4 concentrations.

J Genet Eng Biotechnol 2018 Jun 10;16(1):57-61. Epub 2017 Oct 10.

Child Health Department, National Research Centre, Medical Division, 33 El-Bohouth Street, Dokki, POB:12311, Cairo, Egypt.

Vitamins are evaluated for their role in immunity. Recently, vitamin A received a particular attention as a critical micronutrient for regulating immune system. Therefore, the present study aimed to search for new about vitamin A. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1687157X173008
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http://dx.doi.org/10.1016/j.jgeb.2017.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296595PMC
June 2018
6 Reads

Does India Need a Universal High-Dose Vitamin A Supplementation Program?

Indian J Pediatr 2019 Jan 14. Epub 2019 Jan 14.

Department of Pediatrics and Clinical Epidemiology, Sitaram Bhartia Institute of Science and Research, Qutab Institutional Area, New Delhi, India.

High dose vitamin A (HDVA) concentrate began to be distributed in India in 1970 as a short-term, stop-gap approach to reduce clinical signs of vitamin A deficiency. As this problem declined globally, the purpose of distributing them changed to the reduction of young child mortality. However, their impact on this has also declined, if not disappeared, as suggested in India by the enormous DEVTA study. Read More

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http://dx.doi.org/10.1007/s12098-018-02851-xDOI Listing
January 2019
1 Read

An Investigation of Vitamin Levels Status in the Serum of Children in China.

Biomed Res Int 2018 11;2018:6592757. Epub 2018 Dec 11.

School of Life Science and Technology, Changchun University of Science and Technology, Changchun, China.

This study was to investigate the vitamin levels in the serum of children in the Northeast of China and some factors associated with the vitamin levels. The sera were obtained from 2096 normal children aged 1 month to 12 years in the Northeast of China. Vitamins A and E were detected using their sera by HPLC, and the level of vitamin D was detected by LC-MS. Read More

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http://dx.doi.org/10.1155/2018/6592757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311256PMC
December 2018
1 Read

Insights into the role of bacteria in vitamin A biosynthesis: Future research opportunities.

Crit Rev Food Sci Nutr 2019 Jan 13:1-16. Epub 2019 Jan 13.

a Department of Consumer and Food Sciences , University of Pretoria, Hatfield Campus , Pretoria, South Africa.

Significant efforts have been made to address the hidden hunger challenges due to iron, zinc, iodine, and vitamin A since the beginning of the 21st century. Prioritizing the vitamin A deficiency (VAD) disorders, many countries are looking for viable alternative strategies such as biofortification. One of the leading causes of VAD is the poor bioconversion of β-carotene into retinoids. Read More

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http://dx.doi.org/10.1080/10408398.2018.1546670DOI Listing
January 2019
3 Reads

Factors affecting farmers' willingness and ability to adopt and retain vitamin A-rich varieties of orange-fleshed sweet potato in Mozambique.

Food Secur 2018 25;10(6):1501-1519. Epub 2018 Oct 25.

3Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA USA.

The addition of orange-fleshed sweet potato (OFSP) to the food environment is an effective nutrition-sensitive agricultural approach to improve vitamin A intakes. However, the adoption of this biofortified crop merits further study. The objective of our research was to understand factors that affect Mozambican farmers' adoption and retention of OFSP varieties, with a specific interest in the retention of planting material. Read More

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http://dx.doi.org/10.1007/s12571-018-0845-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308240PMC
October 2018
1 Read

Amaranth Leaves and Skimmed Milk Powders Improve the Nutritional, Functional, Physico-Chemical and Sensory Properties of Orange Fleshed Sweet Potato Flour.

Foods 2019 Jan 4;8(1). Epub 2019 Jan 4.

School of Food Technology, Nutrition and Bioengineering, College of Agricultural and Environmental Sciences, Makerere University, P.O Box 7062 Kampala, Uganda.

Vitamin A deficiency (VAD) and under nutrition are major public health concerns in developing countries. Diets with high vitamin A and animal protein can help reduce the problem of VAD and under nutrition respectively. In this study, composite flours were developed from orange fleshed sweet potato (OFSP), amaranth leaves and skimmed milk powders; 78:2:20, 72. Read More

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http://dx.doi.org/10.3390/foods8010013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351925PMC
January 2019
2 Reads

Insights into retinoic acid deficiency and the induction of craniofacial malformations and microcephaly in fetal alcohol spectrum disorder.

Genesis 2019 01 21;57(1):e23278. Epub 2019 Jan 21.

Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Faculty of Medicine, Hebrew University, Jerusalem, Israel.

Fetal Alcohol Spectrum Disorder (FASD) is a set of neurodevelopmental malformations caused by maternal consumption of alcohol during pregnancy. FASD sentinel facial features are unique to the disorder, and microcephaly is common in severe forms of FASD. Retinoic acid deficiency has been shown to cause craniofacial malformations and microcephaly in animal models reminiscent of those caused by prenatal alcohol exposure. Read More

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http://dx.doi.org/10.1002/dvg.23278DOI Listing
January 2019
2 Reads

Vitamin A deficiency among under-five Nigerian children with diarrhoea.

Afr Health Sci 2018 Sep;18(3):737-742

Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria.

Background: Vitamin A deficiency (VAD) and diarrhoea are still important contributors to childhood deaths in Africa, and vitamin A deficient children are at increased risk as well as severity of diarrhoea.

Objectives: To determine the prevalence of VAD and identify the associated factors among children with diarrhoea.

Methods: The study was a hospital-based cross-sectional descriptive study. Read More

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https://www.ajol.info/index.php/ahs/article/view/176210
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http://dx.doi.org/10.4314/ahs.v18i3.32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307021PMC
September 2018
9 Reads

An Argument for Vitamin D, A, and Zinc Monitoring in Cirrhosis.

Ann Hepatol 2018 Oct;17(6):920-932

Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL, USA.

Malnutrition is prevalent in cirrhosis. Vitamin and mineral deficiencies, including vitamin D, vitamin A, and zinc, are common and have been shown to correlate with survival. Our aim was to review the mechanisms of vitamin D, vitamin A, and zinc deficiencies in cirrhosis and the clinical assessment of affected patients, their outcomes based on the current literature, and management. Read More

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https://annalsofhepatology.publisherspanel.com/gicid/01.3001
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http://dx.doi.org/10.5604/01.3001.0012.7192DOI Listing
October 2018
4 Reads

Effects of vitamin A on growth performance and tissue retinol of starter White Pekin ducks.

Poult Sci 2018 Dec 28. Epub 2018 Dec 28.

Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

A dose-response experiment with 8 supplemental vitamin A levels (0, 500, 1,000, 1,500, 2,500, 3,500, 7,000, and 14,000 IU/kg) were conducted to examine the effects of vitamin A on growth performance and tissue retinol of starter White Pekin ducks. A total of 512 one-day-old male Pekin ducks were randomly divided into 8 treatments and each treatment contained 8 replicate pens of 8 ducks. All these ducks were reared in raised wire-floor pens from hatch to 21 D of age. Read More

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http://dx.doi.org/10.3382/ps/pey571DOI Listing
December 2018
7 Reads

Effectiveness of social marketing in improving knowledge, attitudes and practice of consumption of vitamin A-fortified oil in Tanzania.

Public Health Nutr 2018 Dec 26:1-10. Epub 2018 Dec 26.

3Department of Food Technology, Nutrition and Consumer Sciences,Sokoine University of Agriculture,Morogoro,Tanzania.

Objective: To evaluate the effectiveness of a social marketing intervention in enhancing knowledge, attitudes and practice (KAP) related to consumption of vitamin A-fortified oil.

Design: The intervention employed community events, distribution of educational materials and radio broadcasts. The intervention was assessed in a quasi-experimental non-equivalent control group study design by collecting information on KAP regarding vitamin A-fortified oil consumption before and after 9 months of a 13-month intervention. Read More

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http://dx.doi.org/10.1017/S1368980018003373DOI Listing
December 2018
2 Reads

The ubiquitin ligase HECTD1 promotes retinoic acid signaling required for development of the aortic arch.

Dis Model Mech 2019 Jan 11;12(1). Epub 2019 Jan 11.

Center for Genetic Medicine Research, Children's National Health System, Washington, DC 20010, USA

The development of the aortic arch is a complex process that involves remodeling of the bilaterally symmetrical pharyngeal arch arteries (PAAs) into the mature asymmetric aortic arch. Retinoic acid signaling is a key regulator of this process by directing patterning of the second heart field (SHF), formation of the caudal PAAs and subsequent remodeling of the PAAs to form the aortic arch. Here, we identify the HECTD1 ubiquitin ligase as a novel modulator of retinoic acid signaling during this process. Read More

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http://dx.doi.org/10.1242/dmm.036491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361158PMC
January 2019
1 Read

Clinical Observations, Plasma Retinol Concentrations, and In Vitro Lymphocyte Functions in Children With Sickle Cell Disease.

Ochsner J 2018 ;18(4):308-317

Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA.

Background: Children with sickle cell disease (SCD) often have infections, growth deficits, and impaired immunity, problems that also are observed in individuals with a vitamin A deficiency (plasma retinol concentration <20 μg/dL). The goal of this study was to investigate the association between vitamin A, health status, and the in vitro immune function of children with SCD.

Methods: Fifty-nine children (40 SS, 11 SC, and 8 Sβ [Sβ] hemoglobin genotypes) 9 months to 18 years old were investigated for plasma levels of retinol, retinol binding protein, C-reactive protein, alpha-1-acid glycoprotein, lymphocyte proliferation, and interleukin (IL)-2 activity in supernatant of phytohemagglutinin-treated lymphocytes. Read More

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http://dx.doi.org/10.31486/toj.17.0044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292479PMC
January 2018
2 Reads

Xerosis in Patient with Vitamin A Deficiency - a Case Report.

Cesk Slov Oftalmol 2018 ;73(5-6):222-224

Xerosis is a corneal and ocular surface disease caused by vitamin A deficiency. It is a rare disease in developed countries, but in third world countries it is a common cause of blindness. We describe a typical xerosis in patient with vitamin A deficiency and long-term malnutrition and alcoholism in our case. Read More

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January 2018

Four years after implementation of a national micronutrient powder program in Kyrgyzstan, prevalence of iron deficiency and iron deficiency anemia is lower, but prevalence of vitamin A deficiency is higher.

Eur J Clin Nutr 2018 Dec 6. Epub 2018 Dec 6.

Division of Nutrition, Physical Activity, and Obesity, Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA.

Background/objectives: In 2009, the Ministry of Health of Kyrgyzstan launched a national Infant and Young Child Nutrition (IYCN) program which included point-of-use fortification of foods with micronutrient powders (MNP) containing iron, vitamin A, and other micronutrients. Caretakers of children aged 6-23 months were given 30 sachets of MNP every 2 months. Micronutrient surveys were conducted in 2009 and 2013. Read More

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http://dx.doi.org/10.1038/s41430-018-0368-7DOI Listing
December 2018
3 Reads

Vitamin A Supplementation during Pregnancy Enhances Pandemic H1N1 Vaccine Response in Mothers, but Enhancement of Transplacental Antibody Transfer May Depend on When Mothers Are Vaccinated during Pregnancy.

J Nutr 2018 Dec;148(12):1968-1975

Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Background: In the growing embryo, the vitamin A requirement is tightly regulated. Maternal vitamin A deficiency during pregnancy may alter maternal immune function to accommodate the fetus.

Objective: Our primary objective was to determine the effect of oral vitamin A supplementation (VAS) during pregnancy and until 6 mo postpartum on pandemic H1N1-vaccine responses in mothers and their infants at 6 mo of age. Read More

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https://academic.oup.com/jn/article/148/12/1968/5231141
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http://dx.doi.org/10.1093/jn/nxy228DOI Listing
December 2018
11 Reads

Marginal Vitamin A Deficiency Affects the Expression Levels and Localization of Retinoic Acid Receptor and Retinoid X Receptor in Rats Meibomian Gland.

Curr Eye Res 2018 Dec 4. Epub 2018 Dec 4.

c Department of Ophthalmology , Chongqing Medical University , Chongqing , China.

Purpose: To assess the effects of marginal vitamin A deficiency (MVAD) on rat meibomian gland morphology as well as retinoic acid receptor (RAR) and retinoid X receptor (RXR) amounts and localization.

Methods: Eight adult female rats were randomized into MVAD and vitamin A normal (VAN) groups, and fed vitamin A-deficient and normal control diets, respectively, for 3 weeks before mating. At postnatal week 4 (P4w), eight newborn animals in both groups were euthanized, respectively. Read More

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https://www.tandfonline.com/doi/full/10.1080/02713683.2018.1
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http://dx.doi.org/10.1080/02713683.2018.1554154DOI Listing
December 2018
5 Reads

Nutritional composition and glycemic index analyses of vitamin A-biofortified maize in healthy subjects.

Food Sci Nutr 2018 Nov 8;6(8):2285-2292. Epub 2018 Oct 8.

Food and Nutrition Science Laboratory International Institute of Tropical Agriculture Ibadan Nigeria.

Besides being a veritable tool for easing the problem of vitamin A deficiency (VAD), this study sought to explore another potential health benefit of vitamin A-biofortified maize (VABM). In the present study, the nutritional composition and glycemic index (GI) of tuwo masara (a nonfermented maize-based dumpling), made from VABM and the indigenous white maize (IWM) genotype, were evaluated. VABM showed significantly (<0. Read More

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http://dx.doi.org/10.1002/fsn3.801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261220PMC
November 2018
1 Read

Development and Organization of the Secondary and Tertiary Lymphoid Organs: Influence of Microbial and Food Antigens.

Endocr Metab Immune Disord Drug Targets 2019 ;19(2):128-135

Department of Basic Medical Sciences, Neuroscience and Sensory Organs, University of Bari, School of Medicine, Bari, Italy.

Background: Secondary lymphoid organs (SLO) are distributed in many districts of the body and, especially, lymph nodes, spleen and gut-associated lymphoid tissue are the main cellular sites. On the other hand, tertiary lymphoid organs (TLO) are formed in response to inflammatory, infectious, autoimmune and neoplastic events. Developmental Studies: In the present review, emphasis will be placed on the developmental differences of SLO and TLO between small intestine and colon and on the role played by various chemokines and cell receptors. Read More

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http://dx.doi.org/10.2174/1871530319666181128160411DOI Listing
January 2019
1 Read

Vitamin A supplementation decreases disease activity index in patients with ulcerative colitis: A randomized controlled clinical trial.

Complement Ther Med 2018 Dec 28;41:215-219. Epub 2018 Sep 28.

Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Introduction: Considering the link between vitamin A deficiency and disease activity in ulcerative colitis (UC) and also the association between dietary intake of vitamin A and gastrointestinal symptoms in these patients, this study aimed to investigate the effect of vitamin A supplementation on disease activity in patients with UC.

Method: In the present double-blind randomized controlled clinical trial, one hundred and fifty patients with Mayo score of 6-12 were randomly assigned to receive 25,000 IU/day vitamin A supplements or placebo for two months. The disease activity was calculated by the Mayo clinic score. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09652299183075
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http://dx.doi.org/10.1016/j.ctim.2018.09.026DOI Listing
December 2018
10 Reads

Early neonatal vitamin A supplementation and infant mortality: an individual participant data meta-analysis of randomised controlled trials.

Arch Dis Child 2019 Mar 13;104(3):217-226. Epub 2018 Nov 13.

Department of Maternal, Newborn, Child and Adolescent Health, World Health Organization, Geneva, Switzerland.

Background: Biannual vitamin A supplementation is a well-established survival tool for preschool children 6 months and older in vitamin A deficient populations but this schedule misses the opportunity to intervene on most young infant deaths. Randomised trials of neonatal vitamin A supplementation (NVAS) in the first few days of life to assess its impact on under 6-month mortality in low/middle-income countries have had varying results.

Methods: Investigators of 11 published randomised placebo-controlled NVAS trials (n=163 567 children) reanalysed their data according to an agreed plan and pooled the primary outcomes of mortality from supplementation through 6 and 12 months of age using random effects models and meta-regression. Read More

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http://adc.bmj.com/lookup/doi/10.1136/archdischild-2018-3152
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http://dx.doi.org/10.1136/archdischild-2018-315242DOI Listing
March 2019
16 Reads

Vitamin A Promotes Leydig Cell Differentiation via Alcohol Dehydrogenase 1.

Front Endocrinol (Lausanne) 2018 29;9:644. Epub 2018 Oct 29.

Guangdong Provincial Key Laboratory of Bioengineering Medicine, Department of Cell Biology, Jinan University, Guangzhou, China.

Vitamin A (retinol) is important for multiple functions in mammals. In testis, the role of vitamin A in the regulation of testicular functions is clearly involved in rodents. It is essential for sperm production. Read More

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https://www.frontiersin.org/article/10.3389/fendo.2018.00644
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http://dx.doi.org/10.3389/fendo.2018.00644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216111PMC
October 2018
15 Reads

Bioaccessibility of Biofortified Sweet Potato Carotenoids in Baby Food: Impact of Manufacturing Process.

Front Nutr 2018 23;5:98. Epub 2018 Oct 23.

Nestlé Research Center, Lausanne, Switzerland.

Orange-fleshed sweet potato (OFSP), a biofortified crop rich in β-carotene, can be used as a component of baby food recipes in order to tackle vitamin A deficiency in children <6 years old. In this work, the impact of formulation (addition of pumpkin, oil, and egg yolk) and industrial heat processing (pasteurization, sterilization) on carotenoid content and bioaccessibility was evaluated in an OFSP-based baby puree. A commercial OFSP baby food product from Brazil and a homemade OFSP puree were used as references. Read More

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https://www.frontiersin.org/article/10.3389/fnut.2018.00098/
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http://dx.doi.org/10.3389/fnut.2018.00098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205979PMC
October 2018
22 Reads

Progressive hearing loss in vitamin A-deficient mice which may be protected by the activation of cochlear melanocyte.

Sci Rep 2018 Nov 6;8(1):16415. Epub 2018 Nov 6.

Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea.

Vitamin A deficiency (VAD) produces various pathologic phenotypes in humans and animals. However, evidence regarding the effect of VAD on hearing function has been inconsistent. In this study, we evaluated the effect of VAD on hearing function in two mouse models of VAD. Read More

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http://www.nature.com/articles/s41598-018-34653-8
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http://dx.doi.org/10.1038/s41598-018-34653-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219529PMC
November 2018
9 Reads

Serum vitamin A, zinc and visual function in children with moderate to severe persistent asthma.

J Asthma 2018 Oct 31:1-6. Epub 2018 Oct 31.

a Department of Ophthalmology, Stritch School of Medicine , Loyola University Chicago , Maywood , IL , USA.

Background: Asthma is a common childhood disorder with complex pathobiologic components that may include aspects of nutritional deficit. The contribution of vitamin deficiency, specifically vitamin A, as part of the disease complex has not been well studied, particularly among at risk children. In this study, we examined the prevalence of vitamin A as well as zinc deficiency in conjunction with visual function among an urban pediatric population sample with moderate-severe persistent asthma. Read More

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https://www.tandfonline.com/doi/full/10.1080/02770903.2018.1
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http://dx.doi.org/10.1080/02770903.2018.1531992DOI Listing
October 2018
6 Reads

CT features of lung agenesis - a case series (6 cases).

BMC Med Imaging 2018 10 30;18(1):37. Epub 2018 Oct 30.

Department of Radiology, French Medical Institute for Mothers & Children (FMIC), behind Kabul Medical University, Jamal mina, P.O. Box: 472, Kabul, Afghanistan.

Back Ground: Lung agenesis is a rare congenital anomaly. The main etiology of the disease is unknown whereas genetic, iatrogenic and viral factors as well as vitamin A deficiency during early pregnancy may result in developmental failure of primitive lung bud causing unilateral pulmonary agenesis. Affected patients usually present with variable respiratory symptoms and recurrent chest infection at any age. Read More

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https://bmcmedimaging.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12880-018-0281-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208179PMC
October 2018
5 Reads
0.983 Impact Factor

[Limited knowledge of the effect on child mortality of vaccinations and vitamin A supplementation].

Ugeskr Laeger 2018 Oct;180(44)

Preventive health interventions, including the vaccination and vitamin A supplementation programmes, are implemented in low-income countries with little assessment of the real-life effects on child mortality. Nevertheless, the programmes are frequently credited with large, finite numbers of deaths prevented. Forty years of demographic surveillance in Guinea-Bissau indicates, that vaccines and vitamin A supplementation have effects beyond what can be explained by preventing the target infections and vitamin A deficiency. Read More

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October 2018
3 Reads

β-Cryptoxanthin and zeaxanthin are highly bioavailable from whole-grain and refined biofortified orange maize in humans with optimal vitamin A status: a randomized, crossover, placebo-controlled trial.

Am J Clin Nutr 2018 Oct;108(4):793-802

Interdepartmental Graduate Program in Nutritional Sciences, University of Wisconsin-Madison, Madison, WI.

Background: Biofortification of staple crops with β-carotene is a strategy to reduce vitamin A deficiency, and several varieties are available in some African countries. β-Cryptoxanthin (BCX)-enhanced maize is currently in field trials. To our knowledge, maize BCX bioavailability has not been assessed in humans. Read More

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https://academic.oup.com/ajcn/article/108/4/793/5129171
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http://dx.doi.org/10.1093/ajcn/nqy134DOI Listing
October 2018
3 Reads

Micronutrient Deficiencies, Over- and Undernutrition, and Their Contribution to Anemia in Azerbaijani Preschool Children and Non-Pregnant Women of Reproductive Age.

Nutrients 2018 Oct 11;10(10). Epub 2018 Oct 11.

GroundWork, 7306 Fläsch, Switzerland.

Data on the nutritional situation and prevalence of micronutrient deficiencies in Azerbaijan are scarce, and knowledge about anemia risk factors is needed for national and regional policymakers. A nationally representative cross-sectional survey was conducted to assess the prevalence of micronutrient deficiencies, over- and undernutrition, and to disentangle determinants of anemia in children and women in Azerbaijan. The survey generated estimates of micronutrient deficiency and growth indicators for children aged 0⁻59 months of age (6⁻59 months for blood biomarkers) and non-pregnant women 15⁻49 years of age. Read More

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http://www.mdpi.com/2072-6643/10/10/1483
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http://dx.doi.org/10.3390/nu10101483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213945PMC
October 2018
4 Reads

Vitamin A deficiency is associated with body mass index and body adiposity in women with recommended intake of vitamin A.

Nutr Hosp 2018 10 5;35(5):1072-1078. Epub 2018 Oct 5.

Department of the Basic and Dietetic Nutrition from University Federal of Rio de Janeiro (UFRJ)..

Introduction: evidence indicates that vitamin A is involved in regulating fat mass. A low consumption of vitamin A has been reported in individuals with obesity, as have lower concentrations of this vitamin, than in eutrophic individuals when their dietary intake of vitamin A is not significantly different.

Objective: to investigate vitamin A nutritional status and its association with body mass index (BMI) and body fat in women who have the recommended dietary intake of vitamin A. Read More

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http://dx.doi.org/10.20960/nh.1630DOI Listing
October 2018
2 Reads

Serum Carotenoids Reveal Poor Fruit and Vegetable Intake among Schoolchildren in Burkina Faso.

Nutrients 2018 Oct 4;10(10). Epub 2018 Oct 4.

University of Wisconsin-Madison, Nutritional Sciences Department; Madison, WI 53706, USA.

The health benefits of fruits and vegetables are well-documented. Those rich in provitamin A carotenoids are good sources of vitamin A. This cross-sectional study indirectly assessed fruit and vegetable intakes using serum carotenoids in 193 schoolchildren aged 7 to 12 years in the Western part of Burkina Faso. Read More

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http://www.mdpi.com/2072-6643/10/10/1422
Publisher Site
http://dx.doi.org/10.3390/nu10101422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213241PMC
October 2018
14 Reads

Provitamin supramolecular polymer micelle with pH responsiveness to control release, bioavailability enhancement and potentiation of cytotoxic efficacy.

Colloids Surf B Biointerfaces 2019 Jan 24;173:85-93. Epub 2018 Sep 24.

Allelopathy Group, Department of Organic Chemistry, Institute of Biomolecules (INBIO), Campus de Excelencia Internacional (ceiA3), School of Science, University of Cadiz, C/ República Saharaui, 7, 11510, Puerto Real, Cádiz, Spain. Electronic address:

Encapsulation techniques to generate core/shell systems provide a method that improves physicochemical properties, which are very important in biological applications. β-carotene is a common carotenoid that has shown preventive effects in skin diseases and vitamin A deficiency but this compound has limited water solubility and bioavailability, which hinder its broad application. The use of polyrotaxane compounds formed from cyclodextrins has allowed supramolecular polymer micelles (SMPMs) to be synthesized to encapsulate β-carotene. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2018.09.057DOI Listing
January 2019
3 Reads

Night Blindness, Bitot's Spot & Vitamin A Deficiency.

QJM 2018 Sep 28. Epub 2018 Sep 28.

Department of Internal Medicine, Post-Graduate Institute of Medical Education and Research, Chandigarh, India.

A 19-year-old male, presented with gritting sensation in both the eyes and decrease vision during the night for one month. Eyes examination revealed whitish, foamy lesions on the temporal side of the ocular conjunctiva. The patient was treated with oral vitamin A 200,000 IU on day 0, 1, and at two weeks. Read More

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http://dx.doi.org/10.1093/qjmed/hcy218DOI Listing
September 2018
4 Reads

Vitamin A and β-carotene in pregnant and breastfeeding post-bariatric women in an urban population.

J Perinat Med 2019 Feb;47(2):183-189

Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Washington-Seattle, Seattle, WA, USA.

Background As breastfeeding awareness and social acceptance are increased, maternal nutritional deficiency requires more investigation. Methods A prospective cohort study was conducted to determine if vitamin A deficiency is more common in pregnant, lactating post-bariatric surgery women in an inner city population. Antepartum, women after bariatric surgery and controls with no history of malabsorption were recruited. Read More

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http://dx.doi.org/10.1515/jpm-2018-0142DOI Listing
February 2019
4 Reads