391,695 results match your criteria Vitamin A Deficiency


One-carbon metabolism nutrient intake and the association between body mass index and urinary arsenic metabolites in adults in the Chihuahua cohort.

Environ Int 2018 Dec 12;123:292-300. Epub 2018 Dec 12.

Environmental Science and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Curriculum in Toxicology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:

Background: Exposure to inorganic arsenic (iAs) via drinking water is a serious global health threat. Various factors influence susceptibility to iAs-associated health outcomes, including differences in iAs metabolism. Previous studies have shown that obesity is associated with iAs metabolism. Read More

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December 2018
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Enhanced remedial effects for vitamin D and calcium co-supplementation against pre-existing lead nephrotoxicity in mice: The roles of renal calcium homeostatic molecules.

Biochim Biophys Acta Mol Basis Dis 2018 Dec 12. Epub 2018 Dec 12.

Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Al Abdeyah, PO Box 7607, Makkah, Saudi Arabia. Electronic address:

Background: Lead (Pb) is a toxic heavy metal and nephropathy is common with chronic exposure. Although vitamin D (VD) and calcium (Ca) showed promising protections, their co-administration was not previously investigated in Pb nephrotoxicity. This study measured the potential interactions and remedial effects of VD and/or Ca on established Pb nephropathy. Read More

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December 2018

Integrational analysis of miRNAs data sets as a plausible missing linker between Epstein-Barr virus and vitamin D in relapsing remitting MS patients.

Gene 2018 Dec 12. Epub 2018 Dec 12.

Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Given the multifactorial state of autoimmune complex diseases such as multiple sclerosis (MS), it is not clear if different risk factors act jointly or independently. Despite intensive studies investigating multi aspects of MS risk factors, findings with regards to potential biomarkers that may link these risk factors remained largely inconclusive. System biology or data integration utilizes different validated datasets to extract meaningful information and map the plausible biological pathways and networks. Read More

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December 2018

Alternative splicing of the vitamin D receptor modulates target gene expression and promotes ligand-independent functions.

Toxicol Appl Pharmacol 2018 Dec 12. Epub 2018 Dec 12.

Department of Environmental and Molecular Toxicology, Oregon State University, 1007 Agriculture & Life Sciences Building, Corvallis, OR 97331; USA; LS Pharma, 884 Park St., Lebanon, OR 97355; USA.

Alternative splicing modulates gene function by creating splice variants with alternate functions or non-coding RNA activity. Naturally occurring variants of nuclear receptor (NR) genes with dominant negative or gain-of-function phenotypes have been documented, but their cellular roles, regulation, and responsiveness to environmental stress or disease remain unevaluated. Informed by observations that class I androgen and estrogen receptor variants display ligand-independent signaling in human cancer tissues, we questioned whether the function of class II NRs, like the vitamin D receptor (VDR), would also respond to alternative splicing regulation. Read More

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December 2018

Is the decline in neonatal mortality in northern Ghana, 1996-2012, associated with the decline in the age of BCG vaccination? An ecological study.

BMJ Open 2018 Dec 14;8(12):e023752. Epub 2018 Dec 14.

Navrongo Health Research Centre, Navrongo, Ghana.

Objective: To examine the association between early Bacille Calmette-Guerin (BCG) vaccination and neonatal mortality in northern Ghana.

Methods: This ecological study used vaccination and mortality data from the Navrongo Health and Demographic Surveillance System. First, we assessed and compared changes in neonatal mortality rates (NMRs) and median BCG vaccination age from 1996 to 2012. Read More

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December 2018

Clinical and genetic associations of renal function and diabetic kidney disease in the United Arab Emirates: a cross-sectional study.

BMJ Open 2018 Dec 14;8(12):e020759. Epub 2018 Dec 14.

Center of Biotechnology, Khalifa University, Abu Dhabi, United Arab Emirates.

Objectives: Within the Emirati population, risk factors and genetic predisposition to diabetic kidney disease (DKD) have not yet been investigated. The aim of this research was to determine potential clinical, laboratory and reported genetic loci as risk factors for DKD.

Research Design And Methods: Four hundred and ninety unrelated Emirati nationals with type 2 diabetes mellitus (T2DM) were recruited with and without DKD, and clinical and laboratory data were obtained. Read More

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December 2018

A combination of linalool, vitamin C, and copper synergistically trigger Reactive Oxygen Species, DNA damage and inhibits subsp. serovar Typhi and .

Appl Environ Microbiol 2018 Dec 14. Epub 2018 Dec 14.

Chemical Biology Laboratory, Department of Biotechnology, Indian Institute of Technology Roorkee, Uttarakhand 247 667, India.

Inappropriate and disproportionate use of antibiotics is contributing immensely to the development of antibiotic resistance in bacterial species associated with food contamination. Use of natural products in combination can be a potent alternative hurdle strategy to inactivate foodborne pathogens. Here, we explored pro-oxidant properties of essential oil inalool and itamin C in combination with opper (LVC) in combating foodborne pathogens and a subsp. Read More

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December 2018

Randomized trial of three doses of vitamin D to reduce deficiency in pregnant Mongolian women.

EBioMedicine 2018 Dec 11. Epub 2018 Dec 11.

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA; Connors Center for Women's Health and Gender Biology, Brigham and Women's Hospital, Boston, USA. Electronic address:

Background: In winter in Mongolia, 80% of adults have 25-hydroxyvitamin D (25(OH)D) concentrations <25 nmol/l (<10 ng/ml) and 99% have <50 nmol/l (<20 ng/ml). The vitamin D dose to avert deficiency during pregnancy in this population is unknown.

Methods: We conducted a randomized, controlled, double-blind trial of daily 600, 2000, or 4000 IU vitamin D for pregnant women in Mongolia (Clinicaltrials. Read More

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December 2018

Treatment of hypoparathyroidism.

Best Pract Res Clin Endocrinol Metab 2018 Dec 6. Epub 2018 Dec 6.

San Raffaele Vita Salute University, IRCCS San Raffaele Hospital, Milan, Italy. Electronic address:

The goal of the clinical management of hypoparathyroidism is to correct acute and chronic hypocalcemia. Treatment of acute hypoparathyroidism via intravenous infusion of Ca++ salts, is necessary only in symptomatic patients, or in asymptomatic patients in the setting of a rapid decrease in ionized Ca levels. The treatment cornerstones of chronic hypoparathyroidism are oral supplementation of calcium and/or active vitamin D, that can be associated with dietary restriction of sodium and phosphates, thiazide diuretics, and phosphate binders. Read More

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December 2018

Effect of 800 IU Versus 2000 IU Vitamin D3 With or Without a Simple Home Exercise Program on Functional Recovery After Hip Fracture: A Randomized Controlled Trial.

J Am Med Dir Assoc 2018 Dec 11. Epub 2018 Dec 11.

Department of Geriatrics and Aging Research, University Hospital Zurich and University of Zurich, Switzerland; Centre on Aging and Mobility, University Hospital Zurich and City Hospital Waid Zurich, Switzerland; University Clinic for Acute Geriatric Care, City Hospital Waid, Zurich, Switzerland. Electronic address:

Objectives: To evaluate 2 simple strategies, vitamin D and a home exercise program, in functional recovery during the first year after hip fracture.

Design: Secondary analysis of a factorial clinical trial. Patients were randomly allocated to 800 IU (standard of care) or 2000 IU vitamin D and a daily instruction of a simple home exercise program (SHEP) or standard physiotherapy alone during acute care. Read More

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December 2018

Integrated Care Management of Patients With Atrial Fibrillation and Risk of Cardiovascular Events: The ABC (Atrial fibrillation Better Care) Pathway in the ATHERO-AF Study Cohort.

Mayo Clin Proc 2018 Dec 11. Epub 2018 Dec 11.

Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, United Kingdom; Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Denmark. Electronic address:

Objective: To investigate the impact on cardiovascular events (CVEs) in a real-world population of patients with atrial fibrillation (AF) by implementing the Atrial fibrillation Better Care (ABC: A, Avoid stroke with anticoagulation; B, better symptom management; C, Cardiovascular and comorbidity risk management) pathway.

Patients And Methods: This prospective single-center cohort study included 907 consecutive patients with nonvalvular AF on vitamin K antagonists from February 2008 to December 2016. The A, B, and C groups were defined as follows: "A" by a Time in Therapeutic Range ≥65%; "B" by a European Heart Rhythm Association (EHRA) symptom scale I-II, and "C" as optimized cardiovascular comorbidity management. Read More

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December 2018

Eicosapentaenoic Acid and Vitamin E Against Doxorubicin Induced Cardiac and Renal Damages: Role of Cytochrome c and iNOS.

Arch Iran Med 2018 Nov 1;21(11):502-508. Epub 2018 Nov 1.

Pharmacology and Toxicology Department, Faculty of Pharmacy, October University for Modern Sciences and Arts, Egypt.

Background: The current study aimed to evaluate the mechanisms involved in protection against doxorubicin-induced cardiac and renal toxicities upon treatment with eicosapentaenoic acid and vitamin E.

Methods: Rats were randomly assigned to 4 groups: normal control, doxorubicin inducted control, eicosapentaenoic acid treated group and a final group pretreated with vitamin E. Lipid peroxidation, reduced glutathione (GSH) and tumor necrosis factor-alpha (TNF-α) contents as well as glutathione peroxidase (GPx), superoxide dismutase (SOD) and myeloperoxidase (MPO) activities were assessed. Read More

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November 2018

Role of Lactobacillus rhamnosus (FloraActive™) 19070-2 and Lactobacillus reuteri (FloraActive™) 12246 in Infant Colic: A Randomized Dietary Study.

Nutrients 2018 Dec 13;10(12). Epub 2018 Dec 13.

Lviv Community 4 Clinical Hospital, 3 Yaroslava Stetska str., 79007 Lviv, Ukraine.

Infant colic is a common condition of unknown pathogenesis that brings frustration to families seeking for effective management. Accumulating evidence suggests that some single strains of lactobacilli may play a positive dietary role in attenuation of colic in exclusively breastfed infants. The objective of this study was to evaluate a mixture of two strains in decreasing infant cry and fuss in this population. Read More

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December 2018

Pharmacologic ascorbate as a pro-drug for hydrogen peroxide release to kill mycobacteria.

Biomed Pharmacother 2019 Jan 27;109:2119-2127. Epub 2018 Nov 27.

Scientific Research Center, Shanghai Public Health Clinical Center, Fudan University, Jinshan District, Shanghai, China. Electronic address:

Background And Purpose: Tuberculosis is one of the most highly fatal diseases worldwide, and one-third of the world's population has been infected with Mycobacterium tuberculosis (M. tuberculosis). A previous study showed that M. Read More

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January 2019
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Neuroprotective effects of 1`δ-1`-acetoxyeugenol acetate on Aβ induced cognitive dysfunction in mice.

Biomed Pharmacother 2019 Jan 13;109:1454-1461. Epub 2018 Nov 13.

Department of Pharmacology, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Telangana, 506009, India. Electronic address:

The progressive accumulation of amyloid beta (Aβ) peptide is neurotoxic and leads to Alzheimer's type dementia. Accumulation of Aβ has been associated with dysfunction of hypothalamic-pituitary-adrenal (HPA) axis and elevated pro-inflammatory cytokines. In this study, we investigated the effect of 1`δ-1`-acetoxyeugenol acetate (DAEA), isolated from Alpinia galanga (L. Read More

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January 2019

Retinol palmitate and ascorbic acid: Role in oncological prevention and therapy.

Biomed Pharmacother 2019 Jan 13;109:1394-1405. Epub 2018 Nov 13.

Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City-700000, Vietnam; Department of Biological Sciences, Federal University of Piauí, Picos, Piauí, 64.067-670, Brazil. Electronic address:

Cancer development has been directly related to oxidative stress. During chemotherapy, some cancer patients use dietary antioxidants to avoid nutritional deficiencies due to cancer treatment. Among the antioxidants consumed, there are vitamins, including retinyl palmitate (PR) and ascorbic acid (AA), which have the capacity to reduce free radicals formation, protect cellular structures and maintain the cellular homeostasis. Read More

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January 2019

Vitamin D and liver fibrosis: Molecular mechanisms and clinical studies.

Biomed Pharmacother 2019 Jan 10;109:1351-1360. Epub 2018 Nov 10.

Department of Biochemistry, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand. Electronic address:

Vitamin D plays a primary role in regulation of bone metabolism and calcium homeostasis. Interestingly, emerging evidence suggests protective effects of vitamin D against liver fibrogenesis. However, the precise mechanisms of this action remain mysterious. Read More

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January 2019

Chronic fatigue syndrome (CFS): Suggestions for a nutritional treatment in the therapeutic approach.

Biomed Pharmacother 2019 Jan 5;109:1000-1007. Epub 2018 Nov 5.

Research Department, Innlandet Hospital Trust, Brumunddal, Norway; Inland Norway University of Applied Sciences, Elverum, Norway.

Chronic fatigue syndrome (CFS) is known as a multi-systemic and complex illness, which induces fatigue and long-term disability in educational, occupational, social, or personal activities. The diagnosis of this disease is difficult, due to lacking a proper and suited diagnostic laboratory test, besides to its multifaceted symptoms. Numerous factors, including environmental and immunological issues, and a large spectrum of CFS symptoms, have recently been reported. Read More

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January 2019

Comparative Evaluation of Phytochemicals, and Antidiabetic and Antioxidant Activities of Cuscuta reflexa Grown on Different Hosts in Northern Thailand.

Nat Prod Commun 2017 Jan;12(1):51-54

For the first time, total phytochemical profiles of methanol crude extracts of Cuscuta reflexa grown on three different hosts, Coccinia grandis, Ficus racemosa- and Samanea saman, that were cultivated in northern Thailand were examined, along with their antidiabetic and antioxidant activities. The highest level of total flavonoids (114.4 mg QE/ g extract) and total phenolic content (90. Read More

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January 2017

Warum brauchen Sjuglinge zusatzlich Vitamin D?.

Authors:

Kinderkrankenschwester 2016 Aug;33(10):385-387

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Children's untreated decay is positively associated with past caries experience and with current salivary loads of mutans Streptococci; negatively with self-reported maternal iron supplements during pregnancy: a multifactorial analysis.

J Public Health Dent 2018 Dec 14. Epub 2018 Dec 14.

Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia.

Objectives: This study explored the association of children's salivary characteristics, past caries experience, birth weight, and reported maternal prenatal vitamin and mineral supplementation with the dental untreated decay of the child.

Methods: This cross-sectional study, a sub-study of Griffith University Environments for Healthy Living birth cohort study, was conducted on 174 mother-child dyads. Mother's prenatal usage of vitamin and mineral supplements; child's birthweight; salivary pH, buffering capacity, and levels of salivary MS and LB were explored as risk indicators. Read More

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December 2018

Bacteriome-associated Wolbachia of the parthenogenetic termite Cavitermes tuberosus.

FEMS Microbiol Ecol 2018 Dec 14. Epub 2018 Dec 14.

Evolutionary Biology & Ecology, Université libre de Bruxelles, Avenue F.D. Roosevelt 50, CP 160/12, B-1050 Brussels, Belgium.

Wolbachia has deeply shaped the ecology and evolution of many arthropods, and interactions between the two partners are a continuum ranging from parasitism to mutualism. Non-dispersing queens of the termite Cavitermes tuberosus are parthenogenetically produced through gamete duplication, a mode of ploidy restoration generally induced by Wolbachia. These queens display a bacteriome-like structure in the anterior part of the mesenteron. Read More

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December 2018

Hepatoprotective benefits of vitamin C against perfluorooctane sulfonate-induced liver damage in mice through suppressing inflammatory reaction and ER stress.

Environ Toxicol Pharmacol 2018 Dec 5;65:60-65. Epub 2018 Dec 5.

College of Pharmacy, Guangxi Medical University, Guangxi, Nanning, 530021, PR China. Electronic address:

Our previous studies show that vitamin C (VC) plays promising hepatoprotection in mice. Intrahepatic exposure of perfluorooctane sulfonate (PFOS) can induce dose-dependent cytotoxicity. However, pharmacology-based assessment of VC on PFOS remains uninvestigated. Read More

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December 2018
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Decreased risk of renal impairment in atrial fibrillation patients receiving non-vitamin K antagonist oral anticoagulants: A pooled analysis of randomized controlled trials and real-world studies.

Thromb Res 2018 Dec 6;174:16-23. Epub 2018 Dec 6.

Department of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China.

Background: Patients with warfarin have a potential risk of warfarin-related nephropathy, which could result in the discontinuation of anticoagulation therapy. The question of whether non-vitamin K antagonist oral anticoagulants (NOACs) use is associated with increased risk of renal impairment in atrial fibrillation (AF) patients remains unanswered.

Methods: Studies were systematically searched through Medline, Embase, Cochrane Library databases, and ClinicalTrials. Read More

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December 2018
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Correlation of different cellular assays to analyze T cell-related cytokine profiles in vitamin D-supplemented patients with multiple sclerosis.

Mol Immunol 2018 Dec 11;105:198-204. Epub 2018 Dec 11.

Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, the Netherlands. Electronic address:

Different laboratory approaches have been exploited to analyze an effect of vitamin D supplements on T cell cytokine profiles in multiple sclerosis, with poorly reproducible results. We assessed the correlation between intra-cellular flowcytometry analysis of CD4 T cell-enriched CD3CD8 lymphocytes after PMA/ionomycin stimulation directly ex-vivo or after 72 h pre-stimulation with anti-CD3, and cytokine levels excreted in culture supernatants. Pre-stimulation with anti-CD3 resulted in higher proportions of cells positive for IFN-γ, IL-17 A, IL-4, IL-10 and GM-CSF (all P < 0. Read More

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December 2018

Modulation of vitamin D signaling by the pioneer factor CEBPA.

Biochim Biophys Acta Gene Regul Mech 2018 Dec 11. Epub 2018 Dec 11.

School of Medicine, Institute of Biomedicine, University of Eastern Finland, FI-70211 Kuopio, Finland. Electronic address:

The myeloid master regulator CCAAT enhancer-binding protein alpha (CEBPA) is known as a pioneer factor. In this study, we report the CEBPA cistrome of THP-1 human monocytes after stimulation with the vitamin D receptor (VDR) ligand 1α,25-dihydroxyvitamin D (1,25(OH)D) for 2, 8 and 24 h. About a third of the genomic VDR binding sites co-located with those of CEBPA. Read More

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December 2018
1 Read
6.332 Impact Factor

Vitamin B12 and folate deficiencies are not associated with nutritional or weight status in older adults.

Exp Gerontol 2018 Dec 11. Epub 2018 Dec 11.

Unit for Aging Brain and Dementia, Department of Geriatric Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.

It is not known whether undernutrition causes vitamin B12 and folate deficiencies. The present study aimed to determine whether nutritional status, measured using the Mini Nutritional Assessment (MNA) scale, and body mass index (BMI) are indicators of lower level serum vitamin B12 and folate in older adults. 1007 outpatients aged 65 years or over were included the study. Read More

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December 2018

Vitamin E - The Next 100 Years.

IUBMB Life 2018 Dec 14. Epub 2018 Dec 14.

Vascular Biology Laboratory, JM USDA-HNRCA at Tufts University, Boston, Massachusetts.

α-Tocopherol is the only tocopherol that has been shown to prevent the human deficiency disease Ataxia with Isolated Vitamin E Deficiency (AVED), and thus it is the only one that, for humans, can be called vitamin E. Vitamin E in addition to preventing AVED has documented immune boosting properties and an activity against nonalcoholic hepatosteatosis and low-grade inflammation. Epidemiological studies indicating that vitamin E could prevent cardiovascular events, neurodegenerative disease, macular degeneration, and cancer were in general not confirmed by clinical intervention studies. Read More

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December 2018

Reply to: Towards a Consensus on Vitamin D Supplementation and Bone Health.

Authors:
John F Aloia

J Bone Miner Res 2018 Dec 14. Epub 2018 Dec 14.

Bone Mineral Research Center, New York University (NYU) Winthrop Hospital, Mineola, NY, USA.

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December 2018

Vitamin K: a nutrient which plays a little-known role in glucose metabolism.

Curr Opin Clin Nutr Metab Care 2018 Dec 12. Epub 2018 Dec 12.

Sorbonne Université, Diabetes Department, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris.

Purpose Of Review: Type 2 diabetes is one of the most important public health diseases. Type 2 diabetes pathophysiology involves multiple pathways, in which micronutrients could play a role. Among them, interest has grown concerning vitamin K. Read More

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December 2018

Functional, nutritional and social factors associated with mobility limitations in the elderly: a systematic review.

Salud Publica Mex 2018 Sep-Oct;60(5):579-585

Postgraduate Program in Collective Health, Odontology Department, Federal University of Rio Grande do Norte. Natal, Brazil.

Objective: To systematically review the prevalence and incidence of mobility limitations in the elderly people and their associated factors.

Materials And Methods: Articles in the electronic literature were searched via PubMed, Scopus,,Lilacs, SciELO, PAHO, MedCarib, Repidisca, Wholis, IBCES, PEDro, Medline and Bireme (2012-2016). The instrument STROBE was used to analyze the quality of the work and the PRISMA recommendation was used to structure the review. Read More

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September 2017

Assessment of Serum Vitamin D and Irisin Levels in Obese Patients.

Clin Lab 2018 Oct;64(11)

Background: 25-hydroxyvitamin D and irisin have been found to be involved in the pathogenesis of obesity. The aim of the study is to assess the serum levels of 25-hydroxyvitamin D and irisin in obese patients and to determine the association of 25-hydroxyvitamin D and irisin levels with anthropometric parameters. Methods: The study was carried out on 300 obese patients in addition to 156 healthy age and gender matched subjects as a control group. Read More

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October 2018

Toward Prevention of Mild Cognitive Impairment in Older Adults With Depression: An Observational Study of Potentially Modifiable Risk Factors.

J Clin Psychiatry 2018 Nov 27;80(1). Epub 2018 Nov 27.

Division of Geriatric Psychiatry, Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario, Canada.

Objective: Late-life depression has been associated with increased risk of mild cognitive impairment (MCI) and dementia. Predictors of increased risk are incompletely understood. Identification of potentially modifiable risk factors could facilitate prevention of MCI and dementia. Read More

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November 2018

Relationship between serum high sensitivity C-reactive protein with angiographic severity of coronary artery disease and traditional cardiovascular risk factors.

J Cell Physiol 2018 Dec 12. Epub 2018 Dec 12.

Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, University Putra Malaysia, Malaysia.

Serum high-sensitivity C-reactive protein (hs-CRP) is predictive of coronary artery disease (CAD). The aim of this study was to examine the possible association of hs-CRP with presence and severity of CAD and traditional CAD risk factors. This case-control study was carried out on 2,346 individuals from September 2011 to May 2013. Read More

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December 2018
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Contemporary Management of Direct Oral Anticoagulants During Cardioversion and Ablation for Nonvalvular Atrial Fibrillation.

Pharmacotherapy 2018 Dec 12. Epub 2018 Dec 12.

Professor of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee.

Introduction: As overall prevalence of atrial fibrillation (AF) continues to rise, the number of patients who undergo ablation, or electrical/chemical cardioversion, to restore normal sinus rhythm continues to increase as well. As direct oral anticoagulants (DOACs) have continued to be incorporated into clinical practice for long-term anticoagulation for AF, experience with how best to manage use of DOACs during electrophysiologic procedures is evolving.

Objective: This review is intended to provide health care providers with a summary of current evidence regarding the use of DOACs during cardioversion and catheter ablation and provide key considerations for their use during such electrophysiologic procedures. Read More

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December 2018

Association of Group-specific Component Exon 11 Polymorphisms with Bronchial Asthma in Children and Adolescents.

Scand J Immunol 2018 Dec 12:e12740. Epub 2018 Dec 12.

Genetics Unit, Department of Histology and Cell Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Several studies have investigated the association of Group-specific Component (GC) gene, also known as vitamin D binding protein (VDBP), and various respiratory disorder susceptibility with conflicting results. In this sense, we aimed to investigate whether rs7041 and rs4588 variants confer susceptibility to bronchial asthma in a sample of an Egyptian population and to elucidate by in silico analysis the structural and functional impact of these variants. GC polymorphisms rs7041 and rs4588 were genotyped in 192 Egyptian children and adolescents (96 with asthma and 96 healthy controls) by TaqMan single nucleotide polymorphism genotyping assay. Read More

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December 2018

1α, 25-Dihydroxyvitamin D3 alters ectonucleotidase expression and activity in human cutaneous melanoma cells.

J Cell Biochem 2018 Dec 11. Epub 2018 Dec 11.

Department of Biochemistry and Molecular Biology, PPGBtox, CCNE, Federal University of Santa Maria, Santa Maria, RS, Brazil.

Purpose: We hypothesized that vitamin D decreases rates of adenosine formation in human cutaneous melanoma cells through the inhibition of extracellular adenosine 5'-triphosphate breakdown, thereby affecting tumor cell viability. Therefore, the objective of this study was to explore the mechanisms of action of 1α, 25-dihydroxyvitamin D3 (1,25(OH) D3) on the activity and expression of ectonucleotidases in cutaneous melanoma cells.

Methods: A human melanoma cell line, SK-Mel-28, was treated with 1 to 50 nM of the active vitamin D metabolite (1,25(OH) D3) over 24 hours, followed by determination of NTPDase1/CD39 and ecto-5'-nucleotidase/CD73 activity and expression rates of the purinergic system-related NTPDASE1, NT5E and adenosine deaminase and vitamin D receptor. Read More

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December 2018

Natural forms of vitamin E and metabolites-regulation of cancer cell death and underlying mechanisms.

Authors:
Qing Jiang

IUBMB Life 2018 Dec 11. Epub 2018 Dec 11.

Department of Nutrition Science, Purdue University, West Lafayette, Indiana, 47907, USA.

The disappointing results from large clinical studies of α-tocopherol (αT), the major form of vitamin E in tissues, for prevention of chronic diseases including cancer have cast doubt on not only αT but also other forms of vitamin E regarding their role in preventing carcinogenesis. However, basic research has shown that specific forms of vitamin E such as γ-tocopherol (γT), δ-tocopherol (δT), γ-tocotrienol (γTE) and δ-tocotrienol (δTE) can inhibit the growth and induce death of many types of cancer cells, and are capable of suppressing cancer development in preclinical cancer models. For these activities, these vitamin E forms are much stronger than αT. Read More

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December 2018

[Micronutrients in enteral nutrition formulas. Is it possible to innovate?]

Nutr Hosp 2018 Apr 3;35(Spec no2):13-17. Epub 2018 Apr 3.

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The term "micronutrients" include vitamins and trace elements. Their recommended intakes in enteral formulas has been adhered to RDI/RDA and, in addition, their content is regulated in the European Union. However, deficiencies in micronutrients has been reported in specific patient groups under enteral nutrition (EN) in the last years. Read More

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Cryptogenic stroke prevention through venous thromboembolism prevention: Potential and truth in the advent of non-vitamin K antagonist oral anticoagulants.

J Cardiol Cases 2016 Sep 16;14(3):69-70. Epub 2016 Jul 16.

Department of Medicine (Cardiology), Tokai University Graduate School of Medicine, Isehara, Japan.

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September 2016

Recurrent systemic embolism caused by descending thoracic aortic mural thrombus in a young cannabis abuser.

J Cardiol Cases 2016 Mar 10;13(3):93-95. Epub 2015 Dec 10.

Department of Cardiology, CHRU de Brest, Hôpital de la Cavale Blanche, Brest, France.

Aortic mural thrombi are a rare cause of peripheral arterial embolic events. We report the case of a young man with prior history of Buerger's disease and marijuana abuse. He presented visceral infarctions due to descending thoracic aortic mobile pedunculated thrombus with complex atherosclerosis. Read More

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A Market Basket Survey of Horticultural Fruits for Arsenic and Trace Metal Contamination in Southeast Nigeria and Potential Health Risk Implications.

J Health Pollut 2017 Sep 7;7(15):40-50. Epub 2017 Sep 7.

School of Environmental and Rural Science, University of New England, Armidale, NSW 2351, Australia.

Background: Elevated arsenic and trace metal contamination of the terrestrial food chain represents one of the most significant environmental risk exposures for human populations in developing countries. Metalloid and metal contamination in horticultural crop produce such as fruit is a public health concern in Nigeria. Local fruits are cheap sources of vitamins and minerals for the resident population and pose an important dietary threat of metal(loid) toxicity through consumption. Read More

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September 2017

Serum Retinol, Vitamin D and Zinc Levels in Under Five Children with Acute Lower Respiratory Tract Infections.

Indian J Pediatr 2018 Dec 13. Epub 2018 Dec 13.

Department of Pediatrics, Nalanda Medical College, Patna, 800013, India.

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December 2018
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Renal toxicity of heavy metals (cadmium and mercury) and their amelioration with ascorbic acid in rabbits.

Environ Sci Pollut Res Int 2018 Dec 13. Epub 2018 Dec 13.

Department of Veterinary Biomedical Sciences, PMAS Arid Agriculture University, Rawalpindi, PK-46300, Pakistan.

Cadmium and mercury are among the most toxic and dangerous environmental pollutants that may cause fatal implications. Vitamin C is an important chain-breaking antioxidant and enzyme co-factor against heavy metals. The objective of the present study was to evaluate the toxicological effects of cadmium chloride, mercuric chloride, and their co-administration on biochemical parameters of blood serum and metal bioaccumulation in kidneys and also to elucidate the protective effect of vitamin C in rabbits against these metals. Read More

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December 2018
2 Reads
2.828 Impact Factor

The Role of Vitamins and Minerals in Hair Loss: A Review.

Dermatol Ther (Heidelb) 2018 Dec 13. Epub 2018 Dec 13.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1475 NW 12th Ave. Suite 2175, Miami, FL, 33136, USA.

People commonly inquire about vitamin and mineral supplementation and diet as a means to prevent or manage dermatological diseases and, in particular, hair loss. Answering these queries is frequently challenging, given the enormous and conflicting evidence that exists on this subject. There are several reasons to suspect a role for micronutrients in non-scarring alopecia. Read More

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December 2018
2 Reads

Durian Fruits Discovered as Superior Folate Sources.

Front Nutr 2018 28;5:114. Epub 2018 Nov 28.

Chair of Analytical Food Chemistry, Technical University of Munich, Freising, Germany.

Durian () is a tropical fruit grown in Southeast Asia and highly appreciated by consumers throughout Asia. Folates are a group of vitamins and are essential nutrients for humans. Here we present the folate analysis of different durian cultivars as well as diverse durian products. Read More

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November 2018

Association between serum 25-hydroxyvitamin D, hemoglobin A1c and fasting blood glucose levels in adults with diabetes mellitus.

Biomed Rep 2018 Dec 17;9(6):523-530. Epub 2018 Oct 17.

Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan.

In the present study, the aim was to investigate the association between serum 25-hydroxyvitamin D concentration and measures of glycemic control including hemoglobin A1c (HbA1c) and fasting blood glucose (FBG) in adult patients with diabetes mellitus (DM) from the north of Jordan. Another aim was to compare serum levels of 25-hydroxyvitamin D between patients with good glycemic control and patients with uncontrolled DM. This was a cross-sectional study that included 261 participants with DM. Read More

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December 2018

Association of vitamin D receptor ApaI gene polymorphism with osteoporosis susceptibility in postmenopausal Han Chinese women in Xinjiang.

Biomed Rep 2018 Dec 3;9(6):483-490. Epub 2018 Oct 3.

Department of Pathology, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang 832000, P.R. China.

Osteoporosis is a polygenic disorder and has been demonstrated to be associated with ~30 candidate genes, the majority of which have also been implicated in the regulation of bone mineral density (BMD). Vitamin D receptor (VDR) is the candidate gene that has been most extensively studied. Certain studies have reported that the VDR single nucleotide polymorphism ApaI is associated with the risk of osteoporosis in Caucasian and African women. Read More

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December 2018

Reconstruction and analysis of carbon metabolic pathway of Ketogulonicigenium vulgare SPU B805 by genome and transcriptome.

Sci Rep 2018 Dec 13;8(1):17838. Epub 2018 Dec 13.

School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, 110016, China.

Ketogulonicigenium vulgare has been widely used in vitamin C two-step fermentation. Four K. vulgare strains (WSH-001, Y25, Hbe602 and SKV) have been completely genome-sequenced, however, less attention was paid to elucidate the reason for the differences in 2-KGA yield on genetic level. Read More

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December 2018

Highlights from the literature.

Authors:

Arch Dis Child 2019 Jan;104(1):104

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January 2019