Search our Database of Scientific Publications and Authors

I’m looking for a

    6368 results match your criteria Vitamin A Deficiency

    1 OF 128

    Mutation increasing β-carotene concentrations does not adversely affect concentrations of essential mineral elements in pepper fruit.
    PLoS One 2017 16;12(2):e0172180. Epub 2017 Feb 16.
    Joint FAO/IAEA Division, International Atomic Energy Agency, Vienna International Centre, Vienna, Austria.
    Vitamin and mineral deficiencies are prevalent in human populations throughout the world. Vitamin A deficiency affects hundreds of millions of pre-school age children in low income countries. Fruits of pepper (Capsicum annuum L. Read More

    Small-quantity lipid-based nutrient supplements containing different amounts of zinc along with diarrhea and malaria treatment increase iron and vitamin A status and reduce anemia prevalence, but do not affect zinc status in young Burkinabe children: a cluster-randomized trial.
    BMC Pediatr 2017 Feb 2;17(1):46. Epub 2017 Feb 2.
    Department of Nutrition, Program in International and Community Nutrition, University of California, One Shields Avenue, Davis, CA, 95616, USA.
    Background: We assessed the effects of providing a package of interventions including small-quantity lipid-based nutrient supplements (SQ-LNS) containing 0, 5 or 10 mg zinc and illness treatment to Burkinabe children from 9 to 18 months of age, on biomarkers of zinc, iron and vitamin A status at 18 months and compared with a non-intervention cohort (NIC).

    Methods: Using a two-stage cluster randomized trial design, communities were randomly assigned to the intervention cohort (IC) or NIC, and extended family compounds within the IC were randomly assigned to different treatment groups. IC children (n = 2435) were provided with 20 g SQ-LNS/d containing 0, 5 or 10 mg zinc, 6 mg of iron and 400 μg of vitamin A along with malaria and diarrhea treatment. Read More

    Subclinical inflammation influences the association between vitamin A- and iron status among schoolchildren in Ghana.
    PLoS One 2017 2;12(2):e0170747. Epub 2017 Feb 2.
    Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.
    Background And Objective: In resource-poor settings, micronutrient deficiencies such as vitamin A deficiency may co-exist with iron-deficiency. In this study we assessed the iron and vitamin A status of schoolchildren and the association between vitamin A and iron status.

    Methods: A cross-sectional design using the baseline data of a dietary intervention trial conducted among randomly selected 5-12 years old schoolchildren (n = 224) from 2 rural schools in northern Ghana. Read More

    Vitamin A in pediatrics: An update from the Nutrition Committee of the French Society of Pediatrics.
    Arch Pediatr 2017 Jan 27. Epub 2017 Jan 27.
    Institut de recherche pour le développement, 44, boulevard de Dunkerque, 13572 Marseille, France. Electronic address:
    Vitamin A (retinol) fulfills multiple functions in vision, cell growth and differentiation, embryogenesis, the maintenance of epithelial barriers and immunity. A large number of enzymes, binding proteins and receptors facilitate its intestinal absorption, hepatic storage, secretion, and distribution to target cells. In addition to the preformed retinol of animal origin, some fruits and vegetables are rich in carotenoids with provitamin A precursors such as β-carotene: 6μg of β-carotene corresponds to 1μg retinol equivalent (RE). Read More

    Marginal vitamin A deficiency facilitates Alzheimer's pathogenesis.
    Acta Neuropathol 2017 Jan 27. Epub 2017 Jan 27.
    Children's Nutrition Research Center, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base for Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
    Deposition of amyloid β protein (Aβ) to form neuritic plaques in the brain is the unique pathological hallmark of Alzheimer's disease (AD). Aβ is derived from amyloid β precursor protein (APP) by β- and γ-secretase cleavages and turned over by glia in the central nervous system (CNS). Vitamin A deficiency (VAD) has been shown to affect cognitive functions. Read More

    Socio-economic determinants of vitamin A intake in children under 5 years of age: evidence from Pakistan.
    J Hum Nutr Diet 2017 Jan 26. Epub 2017 Jan 26.
    Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
    Background: Vitamin A deficiency, which is a leading health issue worldwide, is estimated to affect approximately 190 million children globally. The most affected areas are Africa and parts of Southeast Asia.

    Methods: The present study examined the use of vitamin A supplementation and the association between socio-demographic factors and vitamin A supplementation in children aged less than 5 years from a cross-sectional demographic survey of Pakistan. Read More

    Prevalence of anaemia, deficiencies of iron and vitamin A and their determinants in rural women and young children: a cross-sectional study in Kalalé district of northern Benin.
    Public Health Nutr 2017 Jan 25:1-11. Epub 2017 Jan 25.
    1Health Promotion Sciences Department,Mel and Enid Zuckerman College of Public Health,University of Arizona,1295 N. Martin Avenue,Campus PO Box 245163,Tucson,AZ 85724,USA.
    Objective: To identify the magnitude of anaemia and deficiencies of Fe (ID) and vitamin A (VAD) and their associated factors among rural women and children.

    Design: Cross-sectional, comprising a household, health and nutrition survey and determination of Hb, biochemical (serum concentrations of ferritin, retinol, C-reactive protein and α1-acid glycoprotein) and anthropometric parameters. Multivariate logistic regression examined associations of various factors with anaemia and micronutrient deficiencies. Read More

    The interrelationship between bile acid and vitamin A homeostasis.
    Biochim Biophys Acta 2017 Jan 19;1862(5):496-512. Epub 2017 Jan 19.
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Electronic address:
    Vitamin A is a fat-soluble vitamin important for vision, reproduction, embryonic development, cell differentiation, epithelial barrier function and adequate immune responses. Efficient absorption of dietary vitamin A depends on the fat-solubilizing properties of bile acids. Bile acids are synthesized in the liver and maintained in an enterohepatic circulation. Read More

    Vitamin A deficiency suppresses fish immune function with differences in different intestinal segments: the role of transcriptional factor NF-κB and p38 mitogen-activated protein kinase signalling pathways.
    Br J Nutr 2017 Jan 18;117(1):67-82. Epub 2017 Jan 18.
    1Animal Nutrition Institute,Sichuan Agricultural University,Chengdu 611130,People's Republic of China.
    The present study investigated the effects of dietary vitamin A on immune function in the proximal intestine (PI), mid intestine (MI) and distal intestine (DI) of young grass carp (Ctenopharyngodon idella). Fish were fed graded levels of dietary vitamin A for 10 weeks, and then a challenge test using an injection of Aeromonas hydrophila was conducted for 14 d. The results showed that, compared with the optimum vitamin A level, vitamin A deficiency significantly decreased fish growth performance, increased enteritis morbidity, decreased intestinal innate humoral immune response and aggravated intestinal inflammation. Read More

    Serum levels of vitamin A, visual function and ocular surface after bariatric surgery.
    Arq Gastroenterol 2017 Jan-Mar;54(1):65-69
    Hospital de Olhos de Pernambuco (HOPE), Recife, PE, Brasil.
    Background: - Bariatric surgery is the most effective treatment for severe obesity, but the surgery increases the risk of developing nutritional deficiencies, such as vitamin A deficiency. In human metabolism, vitamin A plays a role in vision.

    Objective: - To evaluate serum vitamin A, visual function and ocular surface of patients undergoing bariatric surgery. Read More

    Vitamin profiles in two free-living passerine birds under a metal pollution gradient - A calcium supplementation experiment.
    Ecotoxicol Environ Saf 2017 Apr 9;138:242-252. Epub 2017 Jan 9.
    Department of Biology, University of Turku, 20014 Turku, Finland.
    Vitamin and carotenoid deficiency may impair development in free-living vertebrates, because of the importance of these micronutrients to growth, antioxidant defense and calcium regulation. Micronutrient and calcium insufficiency can be intensified by metal pollution which can interfere with nutrient homeostasis or indirectly reduce food availability. Furthermore, absorption of dietary heavy metals is dependent on food calcium and vitamin levels. Read More

    A rapid assessment and response approach for socially marketed nutrition commodities in Viet Nam.
    Asia Pac J Clin Nutr 2017 Jan;26(1):182-189
    National Institute for Nutrition (NIN), Ha Noi, Vietnam.
    Background: The leading cause of death in children in developing countries is protein-energy malnutrition. In Viet Nam, 25.9% of children under 5 experience stunted growth and 6. Read More

    Nutrition Status of Primary School Students in Two Rural Regions of Guinea-Bissau.
    Food Nutr Bull 2016 Jan 1:379572116679071. Epub 2016 Jan 1.
    1 Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.
    Background: The nutrition status of primary schoolchildren in Africa has received relatively little attention in comparison to that of younger children. We surveyed primary school students in Guinea-Bissau, a nation that is among the poorest in the world.

    Objective: Anthropometry and prevalence of anemia and vitamin A deficiency were assessed in schoolchildren participating in International Partnership for Human Development's school feeding program in 2 regions of Guinea-Bissau. Read More

    Limitations in vitamin A supplementation to optimise serum retinol in preschool children from two central Java districts.
    Asia Pac J Clin Nutr 2016 Dec;25(Suppl 1):S30-S35
    National Institute of Health Research and Development, Ministry of Health, Indonesia.
    Background And Objectives: Vitamin A deficiency is particularly common among children younger than 5 years. In 2011, a study conducted in West Java revealed that the prevalence of vitamin A deficiency in children aged 6-11 months, 12-23 months, and 24-59 months was 18.2%, 15. Read More

    Marginal Vitamin A Deficiency Exacerbates Memory Deficits Following Aβ1-42 Injection in Rats.
    Curr Alzheimer Res 2016 12 23. Epub 2016 Dec 23.
    Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children`s Hospital of Chongqing Medical University, Chongqing 400014, China.
    Background: Although clinical vitamin A deficiency (VAD), which is a public health problem throughout the developing world, has been well controlled, marginal vitamin A deficiency (MVAD) is far more prevalent, especially among pregnant women and preschool children in China. Increasing evidence suggests that VAD is involved in the pathogenesis of Alzheimer's disease (AD). However, whether MVAD, beginning early in life, increases the risk of developing AD has yet to be determined. Read More

    Nutrition situation in Latin America and the Caribbean: current scenario, past trends, and data gaps.
    Rev Panam Salud Publica 2016 Aug;40(2):104-113
    Micronutrient Initiative, Ottawa, Ontario, Canada.
    Objective: To determine the current nutritional status in Latin America and the Caribbean (LAC) and identify data gaps and trends in nutrition surveillance.

    Methods: A systematic Internet search was conducted to identify official sources that allowed for monitoring of LAC countries' nutritional status, including progress toward World Health Organization Global Nutrition Targets 2025. Reports from national nutrition surveillance systems and reports on nationally representative surveys were collected and collated to 1) analyze nutritional status, based on life-course anthropometric indicators and biomarkers, and 2) identify gaps in data availability and trends in nutritional deficiencies. Read More

    Relationship between deficiencies in vitamin A and E and occurrence of infectious diseases among children.
    Eur Rev Med Pharmacol Sci 2016 Dec;20(23):5009-5012
    Department of Pediatrics, Daqing Longnan Hospital, Daqing, Heilongjiang, China.
    Objective: To investigate the relationship between vitamin A deficiency (VAD), vitamin E deficiency (VED) and infectious diseases.

    Patients And Methods: We chose 684 cases of healthy children age 5 months-12 years from our hospital, measured their VA, VE from vein under the light proof condition with high-pressure liquid chromatography. Thereafter, the children who get the acute respiratory tract infection (ARI) or diarrhea two weeks later were registered. Read More

    The impact of home fortification with multiple micronutrient powder on vitamin A status in young children: A multicenter pragmatic controlled trial in Brazil.
    Matern Child Nutr 2016 Dec 7. Epub 2016 Dec 7.
    Department of Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil.
    Home fortification with multiple micronutrient powder (MNP) is effective in the prevention of anemia in young children. However, the impact on their vitamin A status remains controversial. This study aimed to evaluate the effect of MNP on vitamin A status in young Brazilian children. Read More

    A carotenogenic mini-pathway introduced into white corn does not affect development or agronomic performance.
    Sci Rep 2016 Dec 6;6:38288. Epub 2016 Dec 6.
    Crop and Forestry Sciences, School of Agrifood and Forestry Science and Engineering (ETSEA), University of Lleida-Agrotecnio Center, Lleida, Spain.
    High-carotenoid corn (Carolight®) has been developed as a vehicle to deliver pro-vitamin A in the diet and thus address vitamin A deficiency in at-risk populations in developing countries. Like any other novel crop, the performance of Carolight® must be tested in different environments to ensure that optimal yields and productivity are maintained, particularly in this case to ensure that the engineered metabolic pathway does not attract a yield penalty. Here we compared the performance of Carolight® with its near isogenic white corn inbred parental line under greenhouse and field conditions, and monitored the stability of the introduced trait. Read More

    Seasonal dynamics of human retinol status in mobile pastoralists in Chad.
    Acta Trop 2017 Feb 2;166:280-286. Epub 2016 Dec 2.
    Swiss Tropical and Public Health Institute, Socinstrasse 57, P.O. Box, CH-4002 Basel, Switzerland; University of Basel, Petersplatz 1, CH-4003 Basel, Switzerland. Electronic address:
    Vitamin A deficiency is a prevalent public health problem in Africa and South-East Asia, although national population based surveys are lacking in many countries. This study investigated seasonal variation of human retinol concentrations in Chadian mobile pastoralists to identify critical time periods for interventions addressing vitamin A deficiency. The repeated cross-sectional study design used convenience sampling during three seasons to include 327 Fulani, Gorane and Arab adult mobile pastoralists in nine camps in the Lake Chad area. Read More

    Severe anemia in Malawian children.
    Malawi Med J 2016 Sep;28(3):99-107
    Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi; College of Medicine, University of Malawi, Blantyre, Malawi; Emma Children's Hospital, the Global Child Health Group, Academic Medical Center, Amsterdam, The Netherlands; Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
    Background: Severe anemia is a major cause of sickness and death in African children, yet the causes of anemia in this population have been inadequately studied.

    Methods: We conducted a case-control study of 381 preschool children with severe anemia (hemoglobin concentration, <5.0 g per deciliter) and 757 preschool children without severe anemia in urban and rural settings in Malawi. Read More

    Vitamin A deficiency due to bi-allelic mutation of RBP4: There's more to it than meets the eye.
    Ophthalmic Genet 2016 Nov 28:1-2. Epub 2016 Nov 28.
    a University College London Institute of Ophthalmology , University College London , London , UK.
    Vitamin A deficiency is the leading cause of preventable blindness in children worldwide and results in a well-recognized ocular phenotype. Herein we describe a patient presenting to the eye clinic with a retinal dystrophy and ocular colobomata. This combination of clinical signs and consanguineous pedigree structure suggested a genetic basis for the disease, a hypothesis that was tested using whole genome sequencing. Read More

    Vitamin A deficiency and determinants of vitamin A status in Bangladeshi children and women: findings of a national survey.
    Public Health Nutr 2016 Nov 28:1-12. Epub 2016 Nov 28.
    1Nutrition and Clinical Services Division,icddr,b,68 Shaheed Tajuddin Ahmed Sharani,Mohakhali,Dhaka 1212,Bangladesh.
    Objective: Using data from the national micronutrients survey 2011-2012, the present study explored the status of subclinical vitamin A nutrition and the underlying determinants in the Bangladeshi population.

    Design: A nationwide cross-sectional study. Settings The survey covered 150 clusters; fifty in each of rural, urban and slum strata. Read More

    Improvement of anthropometric and biochemical, but not of vitamin A, status in adolescents who undergo Roux-en-Y gastric bypass: a 1-year follow up study.
    Surg Obes Relat Dis 2016 Sep 12. Epub 2016 Sep 12.
    Department of Social and Applied Nutrition, Center for Research on Micronutrients, Institute of Nutrition, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
    Background: The aim of this study was to describe anthropometric, biochemical, co-morbidity, and vitamin A nutritional status in severely obese adolescents before and 30, 180, and 365 days after Roux-en-Y gastric bypass (RYGB).

    Setting: Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

    Methods: Sixty-four adolescents (15-19 years old) with a body mass index≥40 kg/m(2) were enrolled in a prospective follow-up study. Read More

    Metabolic Regulation of Carotenoid-Enriched Golden Rice Line.
    Front Plant Sci 2016 28;7:1622. Epub 2016 Oct 28.
    Laboratory for Translational Research on Transgenic Crops, Department of Botany, University of Calcutta Kolkata, India.
    Vitamin A deficiency (VAD) is the leading cause of blindness among children and is associated with high risk of maternal mortality. In order to enhance the bioavailability of vitamin A, high carotenoid transgenic golden rice has been developed by manipulating enzymes, such as phytoene synthase (psy) and phytoene desaturase (crtI). In this study, proteome and metabolite analyses were carried out to comprehend metabolic regulation and adaptation of transgenic golden rice after the manipulation of endosperm specific carotenoid pathways. Read More

    Provitamin A Carotenoid-Biofortified Maize Consumption Increases Pupillary Responsiveness among Zambian Children in a Randomized Controlled Trial.
    J Nutr 2016 Dec 19;146(12):2551-2558. Epub 2016 Oct 19.
    Center for Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD.
    Background: Impaired dark adaptation is an early functional indicator of vitamin A deficiency that may be prevented by regular dietary intake of foods containing provitamin A carotenoids.

    Objective: We tested the impact of provitamin A carotenoid-biofortified maize consumption (∼15 μg β-carotene/g) on dark adaptation in Zambian children.

    Methods: We used a cluster-randomized trial of children aged 4-8 y (n = 1024) in Mkushi District, Zambia, and compared the regular consumption (2 meals/d, 6 d/wk for 6 mo) of biofortified orange maize (OM) to white maize (WM). Read More

    Diallel analysis of provitamin A carotenoid and dry matter content in cassava (Manihot esculenta Crantz).
    Breed Sci 2016 Sep 26;66(4):627-635. Epub 2016 Aug 26.
    Department of Plant Sciences, University of the Free State , P.O. Box 339, Bloemfontein 9300 , South Africa.
    Global efforts are underway to biofortify cassava (Manihot esculenta Crantz) with provitamin A carotenoids to help combat dietary vitamin A deficiency afflicting the health of more than 500 million resource-poor people in Sub-Saharan Africa. To further the biofortification initiative in Uganda, a 6×6 diallel analysis was conducted to estimate combining ability of six provitamin A clones and gene actions controlling total carotenoid content (TCC), dry matter content (DMC) in cassava roots and other relevant traits. Fifteen F1 families generated from the diallel crosses were evaluated in two environments using a randomized complete block design. Read More

    Effect of Traditional and Extrusion Nixtamalization on Carotenoid Retention in Tortillas Made from Provitamin A Biofortified Maize (Zea mays L.).
    J Agric Food Chem 2016 Nov 31;64(44):8289-8295. Epub 2016 Oct 31.
    Global Maize Program, International Maize and Wheat Improvement Center (CIMMYT), CIMMYT Research Station , Kilometer 45 Carretera Mexico-Veracruz, El Batan, Texcoco, CP 56237, Estado de México, Mexico.
    Provitamin A (proVA) enhanced maize was developed to help alleviate vitamin A deficiency in maize-consuming populations. Nixtamalization (lime-cooking process) is the most commonly used maize-preparation method in Mexico and Central America. In this study, the effect of traditional nixtamalization (TN) and nixtamalized extrusion (NE) on proVA retention was evaluated. Read More

    Serum Retinol Levels in Pregnant Adolescents and Their Relationship with Habitual Food Intake, Infection and Obstetric, Nutritional and Socioeconomic Variables.
    Nutrients 2016 Oct 25;8(11). Epub 2016 Oct 25.
    Department of Clinical Pathology, Faculty of Medical Sciences of the State University of Campinas, Campinas 13083887, São Paulo, Brazil.
    Globally, vitamin A deficiency (VAD) affects about 19.1 million pregnant women. Its occurrence is classically associated with inadequate food intake and may also be associated with socioeconomic factors and the presence of infection. Read More

    The DnaJ-like zinc finger domain protein ORANGE localizes to the nucleus in etiolated cotyledons of Arabidopsis thaliana.
    Protoplasma 2016 Nov 3;253(6):1599-1604. Epub 2015 Dec 3.
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210023, China.
    Vitamin A deficiency (VAD) is a worldwide health problem. Overexpression of the DnaJ-like zinc finger domain protein ORANGE (OR) is a novel strategy for the biofortification of pro-vitamin A carotenoids in different staple crops to alleviate VAD. In plants, OR triggers the differentiation from non-pigmented plastids into carotenoid-accumulating plastids. Read More

    [Serum level of vitamin A in children with pneumonia aged less than 3 years].
    Zhongguo Dang Dai Er Ke Za Zhi 2016 Oct;18(10):980-983
    Department of Pneumology, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.
    Objective: To investigate the association of the serum level of vitamin A (VA) with the severity of pneumonia and recurrent respiratory infection (RRI) within one year after treatment in children with pneumonia, and to provide a basis for serum VA level used as an index for judgment of the condition of pneumonia and prediction of the risk of recurrent respiratory infection.

    Methods: A total of 88 children with pneumonia aged less than 3 years were enrolled as study subjects. Serum VA level was measured on admission, and the development of RRI was followed up by telephone within 1 year after discharge. Read More

    Golden bananas in the field: elevated fruit pro-vitamin A from the expression of a single banana transgene.
    Plant Biotechnol J 2016 Oct 13. Epub 2016 Oct 13.
    Centre for Tropical Crops and Biocommodities, Queensland University of Technology, Brisbane, Qld, Australia.
    Vitamin A deficiency remains one of the world's major public health problems despite food fortification and supplements strategies. Biofortification of staple crops with enhanced levels of pro-vitamin A (PVA) offers a sustainable alternative strategy to both food fortification and supplementation. As a proof of concept, PVA-biofortified transgenic Cavendish bananas were generated and field trialed in Australia with the aim of achieving a target level of 20 μg/g of dry weight (dw) β-carotene equivalent (β-CE) in the fruit. Read More

    Vitamin A deficiency impacts the structural segregation of gut microbiota in children with persistent diarrhea.
    J Clin Biochem Nutr 2016 Sep 6;59(2):113-121. Epub 2016 Aug 6.
    Children's Nutrition Research Center, Children's Hospital of Chongqing Medical University, Zhongshan Second Road of Yuzhong District, Chongqing 400014, China; Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Zhongshan Second Road of Yuzhong District, Chongqing 400014, China.
    To investigate whether gut microbiota is associated with vitamin A nutritional levels in children with persistent diarrhea, a total of 59 pediatric patients with persistent diarrhea aged 1-12 months were selected from the Department of Gastroenterology at the Children's Hospital of Chongqing Medical University, China. Subjects were hospitalized and divided into VA-deficient (n = 30) and VA-normal (n = 29) groups according to their venous serum retinol levels. Fecal samples from all 59 subjects were collected immediately after admission and analyzed by Illumina MiSeq for 16S rRNA genes to characterize the overall microbiota of the samples. Read More

    Planning and Budgeting for Nutrition Programs in Tanzania: Lessons Learned From the National Vitamin A Supplementation Program.
    Int J Health Policy Manag 2016 May 3;5(10):583-588. Epub 2016 May 3.
    Helen Keller International, Dar es Salaam, Tanzania.
    Background: Micronutrient deficiency in Tanzania is a significant public health problem, with vitamin A deficiency (VAD) affecting 34% of children aged 6 to 59 months. Since 2007, development partners have worked closely to advocate for the inclusion of twice-yearly vitamin A supplementation and deworming (VASD) activities with budgets at the subnational level, where funding and implementation occur. As part of the advocacy work, a VASD planning and budgeting tool (PBT) was developed and is used by district officials to justify allocation of funds. Read More

    Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age.
    Cochrane Database Syst Rev 2016 Sep 28;9:CD007480. Epub 2016 Sep 28.
    Department of Pediatrics, D. Brent Polk Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University School of Medicine, Nashville, TN, USA, 37212.
    Background: Vitamin A deficiency is a significant public health problem in low- and middle-income countries. Vitamin A supplementation provided to infants less than six months of age is one of the strategies to improve the nutrition of infants at high risk of vitamin A deficiency and thus potentially reduce their mortality and morbidity.

    Objectives: To evaluate the effect of synthetic vitamin A supplementation in infants one to six months of age in low- and middle-income countries, irrespective of maternal antenatal or postnatal vitamin A supplementation status, on mortality, morbidity and adverse effects. Read More

    Effect of routine prenatal supplementation on vitamin concentrations in maternal serum and breast milk.
    Nutrition 2017 Jan 26;33:261-265. Epub 2016 Jul 26.
    Postgraduate Program in Biochemistry and Molecular Biology, Federal University of Rio Grande do Norte, Natal, Brazil.
    Objective: The aim of the present study was to assess the effect of multivitamin supplements and their different vitamin A sources on retinol concentrations in serum and colostrum milk of postpartum women.

    Methods: This was a retrospective cross-sectional study composed of healthy postpartum women attending two Brazilian private maternity wards (N = 100). According to the type of multivitamin taken during pregnancy, the women were assigned to one of four groups: control group (CG; n = 25), formulation 1 (F1; n = 25), formulation 2 (F2; n = 25), and formulation 3 (F3; n = 25). Read More

    Lower Plasma Levels of Antioxidant Vitamins in Patients with Metabolic Syndrome: A Case Control Study.
    Adv Clin Exp Med 2016 Jul-Aug;25(4):689-700
    Department of Internal and Infectious Diseases, Medical University of Lodz, Poland.
    Background: Metabolic syndrome (MS) is a coexistence of metabolic risk factors affecting the development of cardiovascular diseases. Reactive oxygen species, which are excessively produced in MS, participate in its pathogenesis. Vitamins A, C and E are an important part of the non-enzymatic antioxidative barrier in humans. Read More

    Micronutrient supplementation adherence and influence on the prevalences of anemia and iron, zinc and vitamin A deficiencies in preemies with a corrected age of six months.
    Clinics (Sao Paulo) 2016 Aug;71(8):440-8
    Universidade Federal de Viçosa (UFV), Departamento de Nutrição e Saúde, Viçosa/MG, Brazil.
    Objective: To analyze adherence to the recommended iron, zinc and multivitamin supplementation guidelines for preemies, the factors associated with this adherence, and the influence of adherence on the occurrence of anemia and iron, zinc and vitamin A deficiencies.

    Methods: This prospective cohort study followed 58 preemies born in 2014 until they reached six months corrected age. The preemies were followed at a referral secondary health service and represented 63. Read More

    Elevated vitamin E content improves all-trans β-carotene accumulation and stability in biofortified sorghum.
    Proc Natl Acad Sci U S A 2016 Sep 12;113(39):11040-5. Epub 2016 Sep 12.
    DuPont Pioneer, Johnston, IA 50131;
    Micronutrient deficiencies are common in locales where people must rely upon sorghum as their staple diet. Sorghum grain is seriously deficient in provitamin A (β-carotene) and in the bioavailability of iron and zinc. Biofortification is a process to improve crops for one or more micronutrient deficiencies. Read More

    Prevalence and factors associated with anthropometric failure, vitamin A and iron deficiency among adolescents in a Nigerian urban community.
    Afr Health Sci 2016 Jun;16(2):389-98
    University of Nigeria, Nsukka.
    Background: Under nutrition is a problem of severe magnitude in low income countries like Nigeria. Adolescent school children might also be vulnerable. The dearth of data hinders planning of school health and nutrition programmes for school children. Read More

    Effects of Donor Vitamin A Deficiency and Pharmacologic Modulation of Donor T Cell Retinoic Acid Pathway on the Severity of Experimental Graft-versus-Host Disease.
    Biol Blood Marrow Transplant 2016 Dec 3;22(12):2141-2148. Epub 2016 Sep 3.
    Division of Hematology & Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin; Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin. Electronic address:
    Graft-versus-host disease (GVHD) is the major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). A combination of genetic and nongenetic factors dictates the incidence and severity of GVHD. Recent studies have identified the potential role of the retinoic acid (RA)/retinoic acid receptor (RAR) pathway in the pathogenesis of GVHD. Read More

    Routine vitamin A supplementation for the prevention of blindness due to measles infection in children.
    Cochrane Database Syst Rev 2016 Aug 31(8):CD007719. Epub 2016 Aug 31.
    The Nordic Cochrane Centre, Righospitalet, Bledgamsvej 9, 7811, Copenhagen, Denmark, 2100.
    Background: Reduced vitamin A concentration increases the risk of blindness in children infected with the measles virus. Promoting vitamin A supplementation in children with measles contributes to the control of blindness in children, which is a high priority within the World Health Organization (WHO) VISION 2020 The Right to Sight Program.

    Objectives: To assess the efficacy of vitamin A in preventing blindness in children with measles without prior clinical features of vitamin A deficiency. Read More

    Maternal vitamin A deficiency during pregnancy affects vascularized islet development.
    J Nutr Biochem 2016 Oct 4;36:51-59. Epub 2016 Aug 4.
    Genomics Research Center, Academia Sinica, Nankang, Taipei 115, Taiwan; Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University, Taipei 112, Taiwan. Electronic address:
    Vitamin A deficiency is known to affect 20 million pregnant women worldwide. However, the prenatal effects of maternal vitamin A deficiency on pancreas development have not been clearly determined. The present study examined how maternal vitamin A deficiency affects fetal islet development. Read More

    Low-quality scientific evidence for the continuation of universal Vitamin A supplementation among under 5 children in India.
    Indian J Public Health 2016 Jul-Sep;60(3):176-80
    Research Scientist, Department of Human Nutrition, All India Institute of Medical Sciences, New Delhi, India.
    Vitamin A supplementation (VAS) is presently being undertaken in India among under 5 (U5) children for two possible benefits (i) to prevent nutritional blindness due to Vitamin A deficiency (VAD) and (ii) to reduce U5 mortality. The existing scientific evidence suggests that nutritional blindness due to VAD has been virtually eliminated and also the difference between U5 mortality rate and infant mortality rate is very low for VAS to have any meaningful impact. On the contrary, scientific evidence indicates that there could be side effects of the administration of mega dose of Vitamin A (MDVA). Read More

    Relationship between vitamin A deficiency and the thyroid axis in clinically stable patients with liver cirrhosis related to hepatitis C virus.
    Appl Physiol Nutr Metab 2016 Sep 24;41(9):985-91. Epub 2016 Aug 24.
    c Clinical Pathology Department, Faculty of Medicine, Mansoura University, Egypt.
    Vitamin A deficiency (VAD) and altered thyroid function are commonly encountered in patients with liver cirrhosis. The link between vitamin A metabolism and thyroid function has been previously identified. The aim of this study was to explore the association between VAD and the thyroid axis in clinically stable patients with cirrhosis related to hepatitis C virus (HCV). Read More

    Vitamin A deficiency modulates iron metabolism independent of hemojuvelin (Hfe2) and bone morphogenetic protein 6 (Bmp6) transcript levels.
    Genes Nutr 2016 17;11. Epub 2016 Mar 17.
    Postgraduate Program in Human Nutrition, Faculty of Health Sciences, University of Brasília, Campus Universitário Darcy Ribeiro, POBox 70910-900, Brasília, DF Brazil ; Instituto de Ciências Biológicas, Departamento de Biologia Celular, Laboratório de Bioquímica da Nutrição, Universidade de Brasília, Campus Universitário Darcy Ribeiro, Bloco J, 1 Andar. Asa Norte, Brasília, Distrito Federal CEP: 70910-900 Brasil.
    Background: Considering that vitamin A deficiency modulates hepcidin expression and consequently affects iron metabolism, we evaluated the effect of vitamin A deficiency in the expression of genes involved in the hemojuvelin (HJV)-bone morphogenetic protein 6 (BMP6)-small mothers against decapentaplegic protein (SMAD) signaling pathway.

    Methods: Male Wistar rats were treated: control AIN-93G diet (CT), vitamin A-deficient diet (VAD), iron-deficient diet (FeD), vitamin A- and iron-deficient diet (VAFeD), or 12 mg all-trans retinoic acid (atRA)/kg diet.

    Results: Vitamin A deficiency (VAD) increased hepatic Bmp6 and Hfe2 mRNA levels and down-regulated hepatic Hamp, Smad7, Rarα, and intestinal Fpn1 mRNA levels compared with the control. Read More

    Vitamin A Deficiency Promotes Inflammation by Induction of Type 2 Cytokines in Experimental Ovalbumin-Induced Asthma Murine Model.
    Inflammation 2016 Oct;39(5):1798-804
    Department of Immunology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Avenue, Changchun, 130021, People's Republic of China.
    Vitamin A (VA) deficiency is one of the most common malnutrition conditions. Recent reports showed that VA plays an important role in the immune balance; lack of VA could result in enhanced type 2 immune response characterized by increased type 2 cytokine production and type 2 innate lymphoid cell infiltration and activation. Type 2 immune response plays protective role in anti-infection but plays pathological role in asthmatic disease. Read More

    The effect of enhanced carotenoid content of transgenic maize grain on fungal colonization and mycotoxin content.
    Mycotoxin Res 2016 Nov 13;32(4):221-228. Epub 2016 Aug 13.
    Food Technology Department, University of Lleida, UTPV-XaRTA, Agrotecnio Center, Av. Rovira Roure 191, 25198, Lleida, Spain.
    Novel strategies that address vitamin A deficiency have been developed, such as high-carotenoid maize, a biofortified transgenic maize line rich in carotenoids generated by genetic transformation. The South African white maize inbred (M37W), which is devoid of carotenoids, was engineered to accumulate high levels of β-carotene (provitamin A), lutein, and zeaxanthin. Maize seeds contaminated with fumonisins and other mycotoxins pose a serious threat to both humans and livestock. Read More

    Plasma Retinol Kinetics and β-Carotene Bioefficacy Are Quantified by Model-Based Compartmental Analysis in Healthy Young Adults with Low Vitamin A Stores.
    J Nutr 2016 Oct 10;146(10):2129-2136. Epub 2016 Aug 10.
    Human Nutrition Research Centre and
    Background: Model-based compartmental analysis of data on plasma retinol kinetics after administration of labeled retinol provides unique information about whole-body vitamin A metabolism. If labeled β-carotene is coadministered, its bioefficacy relative to the retinol reference dose can also be estimated.

    Objectives: The objectives were to model plasma retinol kinetics after administration of labeled preformed vitamin A and provitamin A β-carotene and to determine relative β-carotene bioefficacy. Read More

    1 OF 128