Vitamin A deficiency in mice alters host and gut microbial metabolism leading to altered energy homeostasis.
J Nutr Biochem 2017 Nov 5;54:28-34. Epub 2017 Nov 5.
Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, United States. Electronic address:
Vitamin A deficiency (A-) is a worldwide public health problem. To better understand how vitamin A status influences gut microbiota and host metabolism, we systematically analyzed urine, cecum, serum and liver samples from vitamin A sufficient (A+) and deficient (A-) mice using 1H NMR-based metabolomics, quantitative (q)PCR and 16S rRNA gene sequencing coupled with multivariate data analysis. The microbiota in the cecum of A- mice showed compositional as well as functional shifts compared to the microbiota from A+ mice. Read More