54,096 results match your criteria Virtual Reality Biofeedback


Accuracy and Pitfalls in the Assessment of Early Gastrointestinal Lesions.

Dig Dis 2018 Dec 12:1-10. Epub 2018 Dec 12.

Clinic for Gastroenterology and Hepatology, Clinical Center of Serbia, Belgrade, Serbia.

Superficial neoplastic lesions of the digestive tract are usually asymptomatic, and often represent incidental findings on endoscopy. The Paris Classification was developed for the systematic evaluation of superficial lesions of the oesophagus, stomach and colon. The significance of this classification in clinical practice is that it allows the depth of invasion to be estimated. Read More

View Article
December 2018

Eye blinks are perceived as communicative signals in human face-to-face interaction.

PLoS One 2018 12;13(12):e0208030. Epub 2018 Dec 12.

Language and Cognition Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.

In face-to-face communication, recurring intervals of mutual gaze allow listeners to provide speakers with visual feedback (e.g. nodding). Read More

View Article
December 2018

Chasing red herrings: Can visual distracters extend the time children take to open child resistant vials?

PLoS One 2018 12;13(12):e0207738. Epub 2018 Dec 12.

School of Packaging, Michigan State University, East Lansing, MI, United States of America.

Background: Unintentional exposure to medications is a noted problem in pediatric populations despite the prevalent use of child-resistant (CR) packaging and educational campaigns informing consumers about appropriate storage.

Objective: Conduct a proof-of concept study that evaluates how package designs that engage the attention of children in meaningless ways affect opening time and number of openings.

Study Design: Non-CR vials with or without distracters were provided to 108 children (24-51 months) in pairs. Read More

View Article
December 2018

Assessing the Value of Endoscopy Simulator Modules Designed to Prepare Residents for the Fundamentals of Endoscopic Surgery Examination.

Dis Colon Rectum 2018 Nov 28. Epub 2018 Nov 28.

Background: The Fundamentals of Endoscopic Surgery examination is required for all general surgery residents. The test modules are not available for practice before the examination; however, similar modules are commercially available.

Objective: This study aims to determine which modules are most valuable for resident training and preparation for the examination by evaluating which correlates best with experience level. Read More

View Article
November 2018

Virtual Reality for Teletherapy: Avatars May Combine the Benefits of Face-to-Face Communication with the Anonymity of Online Text-Based Communication.

Cyberpsychol Behav Soc Netw 2018 Dec 12. Epub 2018 Dec 12.

School of Psychology, University of Sydney , Sydney, Australia .

Self-disclosure is an essential component of social communication that has been associated with trust, liking, and ultimately strong relationships. As technology continues to develop, so do the number of methods to create and maintain relationships. While speaking face-to-face (FtF) remains the primary way to communicate, computer-mediated communication has become more common, meaning that research into self-disclosure has expanded to new domains, including virtual reality (VR). Read More

View Article
December 2018

Nursing students' perception about humanized care: an integrative review.

Rev Bras Enferm 2018 ;71(suppl 6):2800-2807

Universidade Federal Fluminense, School of Nursing. Niterói, Rio de Janeiro, Brazil.

Objective: To analyze the productions of knowledge about the students' perception of humanized care.

Method: Study of bibliographical revision of the integrative type. The databases Pubmed, Lilacs, Cuiden and the SciELO virtual library were chosen for selection in October 2017, using the health descriptors "Students, Nursing", "Perception" and "Humanization of assistance", in the languages Portuguese, English and Spanish. Read More

View Article
January 2018

Education-service integration in the context of Brazilian medical schools: an integrative review.

Cien Saude Colet 2018 Dec;23(12):4241-4248

Escola Paulista de Medicina, Universidade Federal de São Paulo. Santos SP Brasil.

This paper aimed to characterize the historical trajectory, including the advances and challenges, of the teaching-service integration in the medical training process. In this context, through scientific studies indexed in databases, a critical review of the literature was performed from the search for works of reference until the present moment. Most of the works consulted were reference material on the topic published in scientific journals and indexed in the databases of the Virtual Health Library. Read More

View Article
December 2018

CAN VIRTUAL REALITY BE AS GOOD AS OPERATING ROOM TRAINING? EXPERIENCE FROM A RESIDENCY PROGRAM IN GENERAL SURGERY.

Arq Bras Cir Dig 2018 Dec 6;31(4):e1397. Epub 2018 Dec 6.

Department of Surgery, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Background: The increasingly intense usage of technology applied to videosurgery and the advent of robotic platforms accelerated the use of virtual models in training surgical skills.

Aim: To evaluate the performance of a general surgery department's residents in a video-simulated laparoscopic cholecystectomy in order to understand whether training with virtual reality is sufficient to provide the skills that are normally acquired in hands-on experience at the operating room.

Methods: An observational study with twenty-five first- and second-year general surgery residents. Read More

View Article
December 2018

Practice variations in salivary gland imaging and utility of virtual unenhanced dual energy CT images for the detection of major salivary gland stones.

Acta Radiol 2018 Dec 12:284185118817906. Epub 2018 Dec 12.

1 Department of Radiology, Jewish General Hospital & McGill University, Montreal, QC, Canada.

Background: There are variations in computed tomography (CT) protocols used for evaluating sialolithiasis, with some protocols including acquisitions before and after IV contrast administration. Dual-energy CT (DECT) can be used to generate virtual unenhanced (VUE) images, potentially precluding the need for an uninfused scan.

Purpose: In this study, we performed a survey in order to assess variations in the imaging approach for sialolithiasis and evaluated the accuracy of DECT VUE images for the detection of salivary stones. Read More

View Article
December 2018

Fabrication of obturator prosthesis by fusing CBCT and digital impression data.

Int J Comput Dent 2018 ;21(4):335-344

This clinical report describes a digital workflow using an intraoral digital impression and cone beam computed tomography (CBCT) volumetric data to create a three-dimensional (3D) virtual model of the dentition, defect area, and soft and hard tissue of a patient who had undergone a hemimaxillectomy. Stereolithography (SLA) 3D printing technology was used to produce a resin mold, from which an obturator prosthesis was fabricated through a conventional technique. Read More

View Article
January 2018

Editorial: Modulating Cortical Dynamics in Language, Speech and Music.

Front Integr Neurosci 2018 27;12:58. Epub 2018 Nov 27.

Otto Hahn Group "Neural Bases of Intonation in Speech and Music", Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

View Article
November 2018

User perceptions of avatar-based patient monitoring: a mixed qualitative and quantitative study.

BMC Anesthesiol 2018 Dec 11;18(1):188. Epub 2018 Dec 11.

Institute of Anesthesiology, University Hospital Zurich, Raemistrasse 100, 8091, Zurich, Switzerland.

Background: A new patient monitoring technology called Visual Patient, which transforms numerical and waveform data into a virtual model (an avatar) of the monitored patient, has been shown to improve the perception of vital signs compared to conventional patient monitoring. In order to gain a deeper understanding of the opinions of potential future users regarding the new technology, we have analyzed the answers of two large groups of anesthetists using two different study methods.

Methods: First, we carried out a qualitative analysis guided by the "consolidated criteria for reporting qualitative research" checklist. Read More

View Article
December 2018
1.333 Impact Factor

Hierarchical and programmable one-pot synthesis of oligosaccharides.

Nat Commun 2018 12 6;9(1):5202. Epub 2018 Dec 6.

Genomics Research Center, Academia Sinica, Taipei, 11529, Taiwan.

The programmable one-pot oligosaccharide synthesis method was designed to enable the rapid synthesis of a large number of oligosaccharides, using the software Optimer to search Building BLocks (BBLs) with defined relative reactivity values (RRVs) to be used sequentially in the one-pot reaction. However, there were only about 50 BBLs with measured RRVs in the original library and the method could only synthesize small oligosaccharides due to the RRV ordering requirement. Here, we increase the library to include 154 validated BBLs and more than 50,000 virtual BBLs with predicted RRVs by machine learning. Read More

View Article
December 2018

The Effectiveness of a Virtual Reality-Based Tai Chi Exercise on Cognitive and Physical Function in Older Adults with Cognitive Impairment.

Dement Geriatr Cogn Disord 2018 Dec 11;46(5-6):358-370. Epub 2018 Dec 11.

Department of Physical Therapy and Graduate Institute of Rehabilitation Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Background: Tai Chi (TC) is a Chinese mind-body exercise with proven physical and psychological benefits. A modified TC via virtual reality (VR) may be suitable for the elderly owing to the immediate guidance and feedback regarding movement accuracy. This study explored the cognitive and physical effects of a VR-based TC (VRTC) exercise program on older adults with cognitive impairment (CI). Read More

View Article
December 2018
1 Read

Safe Casting and Reliable Cusp Reconstruction Assisted by Micro-Computed Tomographic Scans of Fossil Teeth.

Anat Rec (Hoboken) 2018 Dec 8. Epub 2018 Dec 8.

Department of Anthropology, The Ohio State University, 4034 Smith Laboratory, 174 West 18th Ave., Columbus, OH 43210, USA.

Dental replicas are frequently utilized in paleoanthropological studies of perikymata and enamel hypoplasia. However, fossil teeth are often fragile and worn, causing two problems: (1) the risk of damage by removing enamel fragments when impression-making material is separated from the fossil tooth surface, and (2) the need to reconstruct worn portions of the crown to assess perikymata number, distribution, and hypoplasia timing. This study presents the advantages of μCT data of canines and lateral incisors for (1) detecting cracks along the enamel-dentine junction (EDJ) which could cause damage when casting, and (2) reliably and non-destructively reconstructing worn or broken cusps. Read More

View Article
December 2018

A multi-step virtual screening protocol for identification of novel non-acidic microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors.

ChemMedChem 2018 Dec 11. Epub 2018 Dec 11.

Gazi Universitesi Eczacilik Fakultesi, Pharmaceutical Chemistry, Tac Sokak No 3, 06580, Ankara, TURKEY.

Microsomal prostaglandin E2 synthase-1 (mPGES-1) is considered as potential therapeutic target for treatment of inflammatory diseases and certain types of cancer. In order to capture novel scaffolds for mPGES-1 inhibition, we applied a virtual screening protocol comprising molecular docking, fingerprints-based clustering with diversity-based selection, protein-ligand interactions fingerprints, and molecular dynamics (MD) simulations with Molecular Mechanic-Poisson Boltzmann Surface Area (MM-PBSA) calculation. The hits identified were carefully analyzed to ensure the selection of novel scaffolds, which make stable interactions with key residues in the mPGES-1 binding pocket and inhibit the catalytic activity of the enzyme. Read More

View Article
December 2018

The importance and adaptive value of life-history evolution for metapopulation dynamics.

J Anim Ecol 2018 Nov 22. Epub 2018 Nov 22.

Department of Biology, Research Group Phycology - Bioinformatics & Evolutionary Genomics, Ghent University, Ghent, Belgium.

The spatial configuration and size of patches influence metapopulation dynamics by altering colonisation-extinction dynamics and local density dependency. This spatial forcing as determined by the metapopulation typology then imposes strong selection pressures on life-history traits, which will in turn feed back on the ecological metapopulation dynamics. Given the relevance of metapopulation persistence for biological conservation, and the potential rescuing role of evolution, a firm understanding of the relevance of these eco-evolutionary processes is essential. Read More

View Article
November 2018
2 Reads

Virtual evaluation of selected cervical lymph nodes with three-dimensional ultrasound in thyroid cancer patients after thyroidectomy.

Head Neck 2018 Dec 9. Epub 2018 Dec 9.

Department of Medicine and Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, New York.

Background: We evaluated the usefulness of three-dimensional (3D) ultrasound of cervical lymph nodes (LN), when two-dimensional (2D) ultrasound evaluation is not sufficient to clearly evaluate lymph node characteristics, in thyroid cancer patients being followed after thyroidectomy.

Methods: Two readers retrospectively analyzed 2D and 3D images of 147 LNs; LNs were categorized as normal, reactive, suspicious, or indeterminate, and confidence level was rated. Results were compared to cytological/clinical data. Read More

View Article
December 2018

An In Silico approach to discover the best molecular modelling strategy for designing novel CDK4 inhibitors.

Chem Biol Drug Des 2018 Dec 8. Epub 2018 Dec 8.

Department of Chemistry, Sree Narayana College, Kollam, Kerala, India, 691001.

Designing of new potential specific inhibitors for CDK4 is very important in cancer therapy. The imperative features that can inhibit CDK4 were identified and refined by docking under standard precision mode, extra precision mode, extra precision mode with core-constraints and induced fit using extra precision protocol. Statistically significant correlation was observed when docking experiments in the extra precision mode carried out by applying core constraints in the ligand molecule which forms two specific hydrogen bonds with Val96 of CDK4. Read More

View Article
December 2018

Understanding Local-Field Correction Factors in the Framework of the Onsager-Böttcher Model.

Chemphyschem 2018 Dec 11. Epub 2018 Dec 11.

Université Lyon 1, ILM (UMR 5306), 10 rue Ada Byron, Bâtiment Kastler, 69622, Villeurbanne, FRANCE.

The determination of the appropriate local-field factor for quantifying the response of a molecule to an external electric field is of major importance in optical spectroscopy. Although numerous studies have dealt with the evolution of the optical properties of emitters as a function of their environment, the choice of the model used to quantify local fields is still ambiguous, and sometimes even arbitrary. In this paper, we review the Onsager-Böttcher model, which introduces the polarizability of the probe molecule as the determinant parameter for the local field factor, and we establish a simple conceptual framework encompassing all commonly used models. Read More

View Article
December 2018

Implementation of a semiautomatic method to design patient-specific instruments for corrective osteotomy of the radius.

Int J Comput Assist Radiol Surg 2018 Dec 10. Epub 2018 Dec 10.

Amsterdam UMC, Department of Biomedical Engineering and Physics, University of Amsterdam, Amsterdam Movement Sciences, 1105 AZ, Amsterdam, The Netherlands.

Purpose: 3D-printed patient-specific instruments (PSIs), such as surgical guides and implants, show great promise for accurate navigation in surgical correction of post-traumatic deformities of the distal radius. However, existing costs of computer-aided design and manufacturing process prevent everyday surgical use. In this paper, we propose an innovative semiautomatic methodology to streamline the PSIs design. Read More

View Article
December 2018

Novel surgical strategy for complicated pulmonary stenosis using haemodynamic analysis based on a virtual operation with numerical flow analysis.

Interact Cardiovasc Thorac Surg 2018 Dec 6. Epub 2018 Dec 6.

Department of Cardiovascular Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.

Objectives: A novel surgical strategy using haemodynamic analyses based on virtual operations with computational simulations has been introduced for complicated pulmonary stenosis. We evaluated the efficacy of this strategy.

Methods: Six patients were enrolled. Read More

View Article
December 2018

Digital Microscopy, Image Analysis, and Virtual Slide Repository.

ILAR J 2018 Dec 7. Epub 2018 Dec 7.

Famke Aeffner, DVM PhD DACVP, is a principal pathologist in the Comparative Biology and Safety Sciences Department at Amgen Inc. in South San Francisco, California. Hibret Adissu, DVM PhD DVSc DACVP, is an investigative pathologist in the Laboratory of Cancer Biology and Genetics, Center for Cancer Research, at the National Cancer Institute in Bethesda, Maryland. Michael C. Boyle, DVM PhD DACVP DABT, is a principal pathologist in the Comparative Biology and Safety Sciences at Amgen Inc. in Thousand Oaks, California. Robert D. Cardiff, MD PhD, is a distinguished professor of pathology (emeritus) at the Center for Comparative Medicine at the University of California in Davis, California. Erik Hagendorn is a senior scientist of informatics at AbbVie Bioresearch in Worcester, Massachusetts. Mark J. Hoenerhoff, DVM PhD DACVP, is an associate professor and veterinary pathologist at the In Vivo Animal Core, Unit for Laboratory Animal Medicine, at the University of Michigan in Ann Arbor, Michigan. Robert Klopfleisch, DVM PhD DACVP, is an associate professor at the Institute of Veterinary Pathology of the Freie Universitaet Berlin, in Berlin, Germany. Susan Newbigging, BSc MSc DVM DVSc, is a pathologist and Director of The Pathology Core at the Toronto Center of Phenogenomics in Toronto, Ontario, Canada. Dirk Schaudien, DVM PhD DACVP, is a veterinary pathologist at the Fraunhofer Institute for Toxicology and Experimental Medicine, in Hannover, Germany. Oliver Turner, BSC(Hons), BVSc MRCVS PhD DACVP DABT, is a senior pathologist in the Preclinical Safety department of Novartis Pharmaceuticals in East Hanover, New Jersey. Kristin Wilson, DVM PhD DACVP, is a pathologist at Flagship Biosciences Inc. in Westminster, Colorado.

Advancements in technology and digitization have ushered in novel ways of enhancing tissue-based research via digital microscopy and image analysis. Whole slide imaging scanners enable digitization of histology slides to be stored in virtual slide repositories and to be viewed via computers instead of microscopes. Easier and faster sharing of histologic images for teaching and consultation, improved storage and preservation of quality of stained slides, and annotation of features of interest in the digital slides are just a few of the advantages of this technology. Read More

View Article
December 2018

MapOptics: A light-weight, cross-platform visualisation tool for optical mapping alignment.

Bioinformatics 2018 Dec 7. Epub 2018 Dec 7.

The Bioinformatics Group, School of Water, Energy and Environment, Cranfield University, College Road, Bedford, UK.

Summary: Bionano optical mapping is a technology that can assist in the final stages of genome assembly by lengthening and ordering scaffolds in a draft assembly by aligning the assembly to a genomic map. However, currently, tools for visualisation are limited to use on a Windows operating system or are developed initially for visualising large-scale structural variation. MapOptics is a lightweight cross-platform tool that enables the user to visualise and interact with the alignment of Bionano optical mapping data and can be used for in depth exploration of hybrid scaffolding alignments. Read More

View Article
December 2018
1 Read

Information visualizations of symptom information for patients and providers: a systematic review.

J Am Med Inform Assoc 2018 Dec 7. Epub 2018 Dec 7.

School of Nursing, Columbia University, New York City, New York USA.

Objective: To systematically synthesize the literature on information visualizations of symptoms included as National Institute of Nursing Research common data elements and designed for use by patients and/or healthcare providers.

Methods: We searched CINAHL, Engineering Village, PsycINFO, PubMed, ACM Digital Library, and IEEE Explore Digital Library to identify peer-reviewed studies published between 2007 and 2017. We evaluated the studies using the Mixed Methods Appraisal Tool (MMAT) and a visualization quality score, and organized evaluation findings according to the Health Information Technology Usability Evaluation Model. Read More

View Article
December 2018
6 Reads

The impact of the tax on sweetened beverages: a systematic review.

Am J Clin Nutr 2018 Sep;108(3):548-563

Department of Public Health, History of Science and Gynecology, Miguel Hernández University, Spain.

Background: Obesity has a serious impact on public health. Sugar-sweetened beverages (SSBs) are implicated in the obesity epidemic. Regulation has been suggested as one approach to limit consumption. Read More

View Article
September 2018

A micro X-ray computed tomography dataset of fossil echinoderms in an ancient obrution bed: a robust method for taphonomic and palaeoecologic analyses.

Gigascience 2018 Dec 7. Epub 2018 Dec 7.

CT Scanner Facility, Central Analytical Facilities, Stellenbosch University, Stellenbosch, South Africa.

Background: Taphonomic and palaeoecologic studies of obrution beds often employ conventional methods of investigation such as physical removal and extraction of fossils from their host rock (matrix) by mechanical preparation. This often-destructive method is not suitable for studying mould fossils, which are voids left in host rocks due to dissolution of the original organism in post-depositional processes.

Findings: Micro computed tomography (µCT) scan data of 24 fossiliferous rock samples revealed thousands of Palaeozoic echinoderms, and digitally "stitching" together individually µCT scanned rock samples within 3D space allows for quantifiable taphonomic data on a fossil echinoderm-rich obrution deposit from the Devonian (Emsian) of South Africa. Read More

View Article
December 2018

Patterns of Pupillary Activity During Binocular Disparity Resolution.

Front Neurol 2018 26;9:990. Epub 2018 Nov 26.

Department of Otolaryngology, University of Miami Hospital, Miami, FL, United States.

This study examined the dynamic coordination between disconjugate, vergence eye movements, and pupil size in 52 normal subjects during binocular disparity stimulation in a virtual reality display. Eye movements and pupil area were sampled with a video-oculographic system at 100 Hz during performance of two tasks, (1) fusion of a binocular disparity step (±1.5° of visual angle in the horizontal plane) and (2) pursuit of a sinusoidally varying binocular disparity stimulus (0. Read More

View Article
November 2018

CABots and Other Neural Agents.

Front Neurorobot 2018 26;12:79. Epub 2018 Nov 26.

Department of Computer Science, Middlesex University London, United Kingdom.

The best way to develop a Turing test passing AI is to follow the human model: an embodied agent that functions over a wide range of domains, is a human cognitive model, follows human neural functioning and learns. These properties will endow the agent with the deep semantics required to pass the test. An embodied agent functioning over a wide range of domains is needed to be exposed to and learn the semantics of those domains. Read More

View Article
November 2018
1 Read

Coral disease prevalence estimation and sampling design.

PeerJ 2018 3;6:e6006. Epub 2018 Dec 3.

Instituto de Ciencias del Mar y Limnología, Universidad Nacional Autónoma de México, Puerto Morelos, Quintana Roo, México.

In the last decades diseases have changed coral communities' structure and function in reefs worldwide. Studies conducted to evaluate the effect of diseases on corals frequently use modified adaptations of sampling designs that were developed to study ecological aspects of coral reefs. Here we evaluate how efficient these sampling protocols are by generating virtual data for a coral population parameterized with mean coral density and disease prevalence estimates from the Caribbean scleractinian at the Mexican Caribbean. Read More

View Article
December 2018

Virtual Reality Analgesia for Pediatric Dental Patients.

Front Psychol 2018 23;9:2265. Epub 2018 Nov 23.

Mechanical Engineering, University of Washington, Seattle, WA, United States.

Dental procedures often elicit pain and fear in pediatric dental patients. To evaluate the feasibility and effectiveness of immersive virtual reality as an attention distraction analgesia technique for pain management in children and adolescents undergoing painful dental procedures. Using a within-subjects design, five patients (mean age 13. Read More

View Article
November 2018

The effectiveness of virtual reality training in reducing the risk of falls among elderly people.

Clin Interv Aging 2018 14;13:2329-2338. Epub 2018 Nov 14.

Department of Nursing, Faculty of Health Sciences, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland.

Background: Virtual reality (VR) training using modern game consoles is an innovative rehabilitation method for fall-prone elderly people. The aim of this study was to assess the effectiveness of VR training using the "Xbox 360 Kinect" in people over 60 years of age.

Materials And Methods: The study involved 23 people, including 19 women and 4 men (mean age 75. Read More

View Article
November 2018

Expanding the role of medical retina virtual clinics using multimodal ultra-widefield and optical coherence tomography imaging.

Clin Ophthalmol 2018 15;12:2337-2345. Epub 2018 Nov 15.

Newcastle Eye Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK,

Background: An increasingly elderly population with a corresponding increase in ophthalmic conditions has led to increased pressure on hospital eye services (HES). In this study, we evaluated the use of a medical retina virtual clinic (MRVC), which has expanded into assessing all new medical retina referrals, where the need for urgent treatment was not clear.

Methods: Retrospective analysis of all new patients who were seen in the MRVC between April 2016 and May 2018. Read More

View Article
November 2018

Validating quantum-classical programming models with tensor network simulations.

PLoS One 2018 10;13(12):e0206704. Epub 2018 Dec 10.

Quantum Computing Institute, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States of America.

The exploration of hybrid quantum-classical algorithms and programming models on noisy near-term quantum hardware has begun. As hybrid programs scale towards classical intractability, validation and benchmarking are critical to understanding the utility of the hybrid computational model. In this paper, we demonstrate a newly developed quantum circuit simulator based on tensor network theory that enables intermediate-scale verification and validation of hybrid quantum-classical computing frameworks and programming models. Read More

View Article
December 2018

[Avances recientes en dermatología comunitaria 2016-2017. Teledermatología, un modelo de enseñanza y asistencia en atención primaria a la salud].

Gac Med Mex 2018 ;154(Supp 2):S36-S40

Presidente de Dermatología Comunitaria México, Subdirección de Enseñanza e Investigación. México.

Introduction: Community dermatology (CD) is integrated by dermatologists, epidemiologists and interested people. It has 27 years of experience at the Guerrero State. Due to unsafety issues, the teaching and medical attention model had to be changed from presential to virtual trough telemedicine. Read More

View Article
January 2018

Joint Speed Discrimination and Augmentation For Prosthesis Feedback.

Sci Rep 2018 Dec 10;8(1):17752. Epub 2018 Dec 10.

Institute of Biomedical Engineering, University of New Brunswick, Fredericton, NB, Canada.

Sensory feedback is critical in fine motor control, learning, and adaptation. However, robotic prosthetic limbs currently lack the feedback segment of the communication loop between user and device. Sensory substitution feedback can close this gap, but sometimes this improvement only persists when users cannot see their prosthesis, suggesting the provided feedback is redundant with vision. Read More

View Article
December 2018

Modulating human mesenchymal stem cells using poly(n-butyl acrylate) networks in vitro with elasticity matching human arteries.

Clin Hemorheol Microcirc 2018 Dec 3. Epub 2018 Dec 3.

Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.

Non-swelling hydrophobic poly(n-butyl acrylate) network (cPnBA) is a candidate material for synthetic vascular grafts owing to its low toxicity and tailorable mechanical properties. Mesenchymal stem cells (MSCs) are an attractive cell type for accelerating endothelialization because of their superior anti-thrombosis and immune modulatory function. Further, they can differentiate into smooth muscle cells or endothelial-like cells and secret pro-angiogenic factors such as vascular endothelial growth factor (VEGF). Read More

View Article
December 2018

Global dynamics of bipedal macaques during grounded and aerial running.

J Exp Biol 2018 Dec 10;221(Pt 24). Epub 2018 Dec 10.

Department of Mechanical Engineering, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.

Macaques trained to perform bipedally use grounded running, skipping and aerial running, but avoid walking. The preference for grounded running across a wide range of speeds is substantially different from the locomotion habits observed in humans, which may be the result of differences in leg compliance. In the present study, based on kinematic and dynamic observations of three individuals crossing an experimental track, we investigated global leg properties such as leg stiffness and viscous damping during grounded and aerial running. Read More

View Article
December 2018

Overview of muographers.

Philos Trans A Math Phys Eng Sci 2018 Dec 10;377(2137). Epub 2018 Dec 10.

Earthquake Research Institute, The University of Tokyo, Tokyo 113-0032, Japan.

By observing the growth of a research community, particularly the factors of size and strength of involvement, it is possible to evaluate the vitality of a new field. The emerging technology of muography, a new visualization technique to look through gigantic objects with an elementary particle called the muon, is the focus of this study. Recently, the initial applications of muography to the study of structures such as pyramids and volcanoes have been expanding to include more commercial interests such as inspecting social infrastructures and energy and mineral resources. Read More

View Article
December 2018

Pedal and haptic estimates of slant suggest a common underlying representation.

Acta Psychol (Amst) 2018 Dec 7;192:194-199. Epub 2018 Dec 7.

Department of Psychology, The Ohio State University Mansfield, United States of America.

It is well known that people verbally exaggerate the slant of visually perceived geographical, virtual, and man-made hills. More recently it has been shown that haptic and verbal estimates of slant result in similar exaggerations, supporting the proprioception calibration hypothesis-that similar biases exist in both verbal estimates of visually perceived slant and proprioceptively perceived hand orientation. This seems to point to a common underlying representation of slant. Read More

View Article
December 2018

A two-dimensional (2D) systems biology-based discrete liver tissue model: A simulation study with implications for ultrasound elastography of liver fibrosis.

Comput Biol Med 2018 Dec 1;104:227-234. Epub 2018 Dec 1.

Department of Biomedical Engineering, Michigan Technological University, Houghton, MI, 49931, USA; Department of Mechanical Engineering and Engineering Mechanics, Michigan Technological University, Houghton, MI, 49931, USA. Electronic address:

Continuum tissue models that were often used to simulate or analyze the mechanical properties of tissues being imaged may not be biologically realistic. Our primary objective was to establish the feasibility of using systems biology to construct biologically relevant tissue models linking tissue structure, composition and architecture to the ultrasound measurements directly. The first application was designated to model fibrotic liver tissues. Read More

View Article
December 2018

Virtual reality simulator versus box-trainer to teach minimally invasive procedures: a meta-analysis.

Int J Surg 2018 Dec 6. Epub 2018 Dec 6.

General Surgery Department, University of Sao Paulo School of Medicine, Carvalho Aguiar Street, Number 255, São Paulo, SP, 05422-090, Brazil.

Background: To evaluate the effectiveness of virtual reality simulator (VRS) training compared to box-trainer training (BT) for learning outcomes in minimally invasive surgery (MIS) techniques.

Materials And Methods: A systematic review of the literature was performed using CENTRAL, MEDLINE, EMBASE, Scopus, CINAHL, LILACS. The primary outcomes were time to perform MIS and performance score in MIS. Read More

View Article
December 2018

Sonographic Characteristics of Papillary Thyroid Carcinoma with Coexistent Hashimoto's Thyroiditis: Conventional Ultrasound, Acoustic Radiation Force Impulse Imaging and Contrast-Enhanced Ultrasound.

Ultrasound Med Biol 2018 Dec 8. Epub 2018 Dec 8.

Department of Ultrasound Diagnosis, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Our objective was to provide the various sonographic characteristics of papillary thyroid carcinomas for Hashimoto's thyroiditis (HT) patients, including conventional ultrasound (US), acoustic radiation force impulse Virtual Touch imaging and quantification (ARFI-VTIQ) and contrast-enhanced ultrasound (CEUS). Sixty-nine HT patients with 85 thyroid nodules (TNs) (49 malignant and 36 benign) were enrolled in this study. We evaluated the size, shape, margin, echogenicity, presence of halo, calcification, vascularity and ARFI-VTIQ and CEUS parameters for each nodule and compared the findings with the reference standards of histopathological and/or cytologic results. Read More

View Article
December 2018
4 Reads

Measuring the greater curvature length of virtual stent graft can provide accurate prediction of stent graft position for thoracic endovascular aortic repair.

J Vasc Surg 2018 Oct 24. Epub 2018 Oct 24.

Department of Radiology, Nara Medical University, Kashihara, Japan.

Objective: The objective of this study was to assess the accuracy of predicting stent graft position for thoracic endovascular aortic repair by measuring three lengths of the virtual stent graft: smaller curvature (SC), center lumen line (CL), and greater curvature (GC).

Methods: From January 2012 to December 2016, patients treated at our institution were analyzed retrospectively. Patients who were treated with more than two devices, patients treated for aortic dissection, and cases without complete preoperative or postoperative computed tomography (CT) data were excluded. Read More

View Article
October 2018

Tryptophan 32 mediates SOD1 toxicity in a in vivo motor neuron model of ALS and is a promising target for small molecule therapeutics.

Neurobiol Dis 2018 Dec 4. Epub 2018 Dec 4.

Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada; Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, AB T6G 2M8, Canada; Department of Medical Genetics, University of Alberta, Edmonton T6G 2H7, Canada. Electronic address:

SOD1 misfolding, toxic gain of function, and spread are proposed as a pathological basis of amyotrophic lateral sclerosis (ALS), but the nature of SOD1 toxicity has been difficult to elucidate. Uniquely in SOD1 proteins from humans and other primates, and rarely in other species, a tryptophan residue at position 32 (W32) is predicted to be solvent exposed and to participate in SOD1 misfolding. We hypothesized that W32 is influential in SOD1 acquiring toxicity, as it is known to be important in template-directed misfolding. Read More

View Article
December 2018

Discovery of a natural PI3Kδ inhibitor through virtual screening and biological assay study.

Biochem Biophys Res Commun 2018 Dec 6. Epub 2018 Dec 6.

School of Traditional Chinese Medicine, Capital Medical University, Fengtai District, Beijing, 100069, PR China; Beijing Key Laboratory of Traditional Chinese Medicine Collateral Disease Theory Research, Capital Medical University, Fengtai District, Beijing, 100069, PR China. Electronic address:

Phosphoinositide-3-kinase-δ (PI3Kδ) is a key regulator in the process of IgE mediated mast cell degranulation, which directly induces allergic diseases, such as asthma. This study is aimed at discovery of natural PI3Kδ inhibitors from Chinese medicine and evaluating their anti-mast cell degranulation activity. A combined virtual screening based on 3D pharmacophore model and molecular docking was used to screen for bioactive ingredients directly targeting PI3Kδ. Read More

View Article
December 2018
1 Read

Use of virtual games for interactive learning in a pharmacy curriculum.

Curr Pharm Teach Learn 2019 Jan 9;11(1):51-57. Epub 2018 Oct 9.

Statistical Consulting, P.O. Box 3253, Newport Beach, CA 92659, United States. Electronic address:

Background And Purpose: To evaluate student pharmacists' attitudes and satisfaction toward playing educational virtual games in the classroom.

Educational Activity And Setting: Virtual games were played in the classroom setting. First year student pharmacists participated in two Mimycx quests in the Healthcare Communication and the Psychiatry/Neurology courses. Read More

View Article
January 2019

Impact of a simulated electronic health record on pharmacy students' perceptions of preparedness for clinical practice.

Curr Pharm Teach Learn 2018 Dec 12;10(12):1624-1630. Epub 2018 Sep 12.

Philadelphia College of Pharmacy at University of the Sciences, 600 South 43rd Street, Philadelphia, PA 19104, United States. Electronic address:

Background And Purpose: The growing use of electronic health records (EHRs) in clinical practice highlights the need to incorporate simulated EHRs into the curriculum of healthcare professions. The purpose of this study was to evaluate the impact of a simulated EHR on student performance and to describe students' perceptions of preparedness to use an EHR in clinical practice.

Educational Activity And Setting: A simulated EHR was introduced to third-year pharmacy students in a practice lab and case studies course series. Read More

View Article
December 2018

Exploring virtual reality as a platform for distance team-based learning.

Curr Pharm Teach Learn 2018 Oct 21;10(10):1384-1390. Epub 2018 Jul 21.

The University of Texas at Tyler, Ben and Maytee Fisch College of Pharmacy, Department of Pharmaceutical Sciences, 3900 University Boulevard, Tyler, TX 75799, United States. Electronic address:

Background And Purpose: Online distance education has become popular in pharmacy education, but it can be challenging to provide engaging experiences such as team-based learning (TBL) in this format. This study explored the utility of virtual reality (VR) as a platform to provide the engaging elements of TBL, without students needing to be physically present in the same room.

Educational Activity And Setting: Volunteers participated in a modified TBL exercise in VR, followed by a survey of the experience. Read More

View Article
October 2018

Combination of ultrasound elastography with TI-RADS in the diagnosis of small thyroid nodules (≤10 mm): A new method to increase the diagnostic performance.

Eur J Radiol 2018 Dec 28;109:33-40. Epub 2018 Oct 28.

Department of Diagnostic Ultrasound, Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, No. 164 Lan Xi Road, Shanghai 200062, China. Electronic address:

Objective: To evaluate the diagnostic performance of a new method of combined ultrasound elastography (UE) and thyroid imaging-reporting and data system (TI-RADS) in the differential diagnosis of small thyroid nodules.

Methods: Ultrasonography(US), TI-RADS, Elasticity Imaging (EI), Virtual Touch Tissue Imaging (VTI) and Virtual Touch Tissue Quantification (VTQ) features of 142 thyroid nodules (maximum diameter ≤10 mm according to conventional ultrasound measurement) confirmed by surgery or FNA were retrospectively analyzed. Different elastographic methods in small benign and malignant thyroid nodules were compared. Read More

View Article
December 2018