15,077 results match your criteria Viral Infections of the Mouth


Cellular DNAJA3, a Novel VP1-Interacting Protein, Inhibits Foot-and-Mouth Disease Virus Replication by Inducing Lysosomal degradation of VP1 and Attenuating its Antagonistic Role on the IFN-β signaling pathway.

J Virol 2019 Apr 17. Epub 2019 Apr 17.

State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Diseases Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, Gansu, China

DnaJ Heat Shock Protein Family (Hsp40) Member A3 (DNAJA3) plays an important role in viral infections. However, the role of DNAJA3 in replication of foot-and-mouth-disease virus (FMDV) remains unknown. In this study, DNAJA3, a novel binding partner of VP1, was identified using yeast two-hybrid screening. Read More

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http://dx.doi.org/10.1128/JVI.00588-19DOI Listing

Enterovirus A71 Containing Codon-Deoptimized VP1 and High-Fidelity Polymerase as Next Generation Vaccine Candidate.

J Virol 2019 Apr 17. Epub 2019 Apr 17.

Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan

Enterovirus A71 (EV-A71) is the major pathogen which causes hand-foot-and-mouth disease (HFMD) which occasionally results in severe neurological complications. In this study, we developed four EV-A71 (rgEV-A71) strains by reverse genetics procedures as possible vaccine candidates. The four rgEV-A71 viruses contained various codon deoptimized VP1 capsid protein (VP1-CD) showed similar replication rate and antigenicity to wild-type virus, while a fifth virus, rg4643C4VP-CD, was unable to form plaques, but was still able to examined by TCID50 titers which were similar to the others, thus indicating the effect of CD on plaque formation. Read More

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http://dx.doi.org/10.1128/JVI.02308-18DOI Listing
April 2019
1 Read

Monoclonal antibodies point to Achilles' heel in picornavirus capsid.

Authors:
Mihnea Bostina

PLoS Biol 2019 Apr 17;17(4):e3000232. Epub 2019 Apr 17.

Department of Microbiology and Immunology and Otago Micro and Nano Imaging, University of Otago, Dunedin, New Zealand.

Picornaviruses are small, icosahedral, nonenveloped, positive-sense, single-stranded RNA viruses that form one of the largest and most important viral families. Numerous Picornaviridae members pose serious health or agricultural threats, causing diseases such as poliomyelitis, hepatitis A, or foot-and-mouth disease. The antigenic characterization of picornavirus capsids plays an important role in understanding the mechanism of viral neutralization and the conformational changes associated with genome release, and it can point to regions which can be targeted by small-molecule compounds to be developed as antiviral inhibitors. Read More

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http://dx.doi.org/10.1371/journal.pbio.3000232DOI Listing
April 2019
2 Reads

Study on seroprevalence and serotyping of foot and mouth disease in Chad.

Rev Sci Tech 2018 Dec;37(3):937-947

Foot and mouth disease (FMD) is a highly contagious viral disease that affects all Artiodactyla. Seven immunologically distinct serotypes of FMD virus (FMDV) exist. In Chad, although FMD is included in the list of diseases monitored by the Chadian Animal Disease Surveillance Network (REPIMAT), the epidemiological situation remains unclear. Read More

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http://doc.oie.int/dyn/portal/index.seam?page=alo&aloId=
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http://dx.doi.org/10.20506/37.3.2897DOI Listing
December 2018
2 Reads

HPV Status and Survival in Non-Oropharyngeal Squamous Cell Carcinoma of the Head and Neck.

Anticancer Res 2019 Apr;39(4):1907-1914

Department of Internal Medicine, Division of Oncology-Hematology, VA Nebraska Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, U.S.A.

Background/aim: HPV-mediated oropharyngeal squamous cell carcinoma is associated with an increased survival. The prognostic value of HPV status for other primary sites is unclear. We aimed to assess the effect of HPV status on overall survival in patients with non-oropharyngeal head and neck squamous cell carcinoma (non-OPSCC) using the National Cancer Database (NCDB). Read More

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http://dx.doi.org/10.21873/anticanres.13299DOI Listing
April 2019
1 Read

Multiplex detection of six swine viruses on an integrated centrifugal disk using loop-mediated isothermal amplification.

J Vet Diagn Invest 2019 Apr 4:1040638719841096. Epub 2019 Apr 4.

Institute of Animal Quarantine, Chinese Academy of Inspection and Quarantine, Beijing, China (Yuan, Deng, C Wang, Lv, Lin, Wu).

Advances in molecular testing and microfluidic technologies have opened new avenues for rapid detection of animal viruses. We used a centrifugal microfluidic disk (CMFD) to detect 6 important swine viruses, including foot-and-mouth disease virus, classical swine fever virus, porcine reproductive and respiratory swine virus-North American genotype, porcine circovirus 2, pseudorabies virus, and porcine parvovirus. Through integrating the loop-mediated isothermal amplification (LAMP) method and microfluidic chip technology, the CMFD could be successfully performed at 62℃ in 60 min. Read More

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http://dx.doi.org/10.1177/1040638719841096DOI Listing
April 2019
1 Read

Molecular characteristic analysis for the VP1 region of coxsackievirus A6 strains isolated in Jiujiang area, China, from 2012 to 2013.

Medicine (Baltimore) 2019 Apr;98(14):e15077

Department of Histology and Embryology, Bengbu Medical College, Bengbu, Anhui, P.R. China.

Background: Enterovirus 71 (EV-A71) and Coxsackievirus A16 (CV-A16) are the most common causative agents causing hand, foot, and mouth disease (HFMD). However, coxsackievirus A6 (CV-A6), previously largely ignored, became the predominant pathogen in China in 2012. The objective of this study is to investigate the genetic characteristics and molecular epidemiology of HFMD caused by CV-A6 to guide the diagnosis and treatment of the disease, as well as disease prevention. Read More

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http://dx.doi.org/10.1097/MD.0000000000015077DOI Listing
April 2019
2 Reads

Low topotype diversity of recent foot-and-mouth disease virus serotypes O and A from districts located along the Uganda and Tanzania border.

J Vet Sci 2019 Mar 28;20(2):e4. Epub 2019 Feb 28.

Institute of Biodiversity Animal Health and Comparative Medicine, University of Glasgow, Glasgow, G128QQ, United Kingdom.

Foot-and-mouth disease (FMD) is one of the most important livestock diseases in East Africa with outbreaks reported annually that cause severe economic losses. It is possible to control disease using vaccination, but antigenic matching of the vaccine to circulating strains is critical. To determine the relationship between foot-and-mouth disease viruses circulating in districts along the Uganda and Tanzanian border between 2016 and 2017 and currently used vaccines, phylogenetic analysis of the full VP1 virus sequences was carried out on samples collected from both sides of the border. Read More

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http://dx.doi.org/10.4142/jvs.2019.20.e4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441803PMC
March 2019
1 Read
1.164 Impact Factor

Characterization of lymphocyte subsets in peripheral blood cells of children with EV71 infection.

J Microbiol Immunol Infect 2019 Mar 14. Epub 2019 Mar 14.

Virus Laboratory, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 318 Renminzhong Road Yuexiu District, Guangzhou, 510120, China. Electronic address:

Background: Enterovirus 71 (EV71) is one of the major causative pathogens of hand, foot, and mouth disease (HFMD). Immune cells play a critical role in determining the outcomes of virus infection. We aimed to characterize the lymphocyte subsets and transcriptional levels of T lymphocytes-associated transcription factors in peripheral blood cells of children with EV71 infection. Read More

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http://dx.doi.org/10.1016/j.jmii.2019.03.001DOI Listing
March 2019
1 Read

Treatment and long-term follow-up of a cat with leishmaniosis.

Parasit Vectors 2019 Mar 26;12(1):121. Epub 2019 Mar 26.

Department of Veterinary Medicine, University of Bari, St. prov. per Casamassima km 3, Bari, Italy.

Background: Leishmania infection in cats is being increasingly reported in endemic areas. Nevertheless, only a few clinical cases have been described in cats, and even fewer have provided information on the response to treatment and a proper follow-up. Here we report a case of feline leishmaniosis not associated with any other disease or co-infection and document its response to allopurinol treatment and long-term follow-up data. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13071-019-3388-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434852PMC
March 2019
4 Reads

Identification of a conserved linear epitope using monoclonal antibody against non-structural protein 3A of foot-and-mouth disease virus with potential for differentiation between infected and vaccinated animals.

Res Vet Sci 2019 Mar 15;124:178-185. Epub 2019 Mar 15.

Division of Livestock Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, NO. 678 Haping Road Xiangfang District, Harbin 150069, PR China. Electronic address:

Foot-and-mouth disease (FMD) is a highly contagious and economically devastating viral disease of cloven-hoofed animals. Vaccination is a key element in the control of FMD among countries where the disease is enzootic. Differentiating infected from vaccinated animals in herds after immunization is an important component of effective eradication strategies. Read More

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http://dx.doi.org/10.1016/j.rvsc.2019.03.015DOI Listing

Serological and molecular epidemiology of foot-and-mouth disease viruses in agro-pastoralist livestock herds in the Kachia Grazing Reserve, Nigeria.

Transbound Emerg Dis 2019 Mar 22. Epub 2019 Mar 22.

Vesicular and Exotic Diseases Unit, Veterinary and Agrochemical Research Centre (CODA-CERVA), Brussels, Belgium.

The Kachia Grazing Reserve (KGR) is located in Kaduna state in north-western Nigeria and consists of 6 contiguous blocks housing 744 defined households (HH), all engaged in livestock keeping. It is considered as a homogenous epidemiological unit and a defined study area. In 2012, all cattle and sheep of 40 selected HH were sampled to determine sero-prevalence of antibodies to foot-and-mouth disease virus (FMDV) and of FMDV. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13182
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http://dx.doi.org/10.1111/tbed.13182DOI Listing
March 2019
4 Reads

A Novel Murine Model Expressing a Chimeric mSCARB2/hSCARB2 Receptor is Highly Susceptible to Oral Infection with Clinical Isolates of EV71.

J Virol 2019 Mar 20. Epub 2019 Mar 20.

Graduate Institute of Biomedical Science, Chang Gung University, Guishan, Taoyuan, Taiwan

EV71 infection is generally associated with hand-foot-mouth disease (HFMD), and may cause severe neurological disorders and even death. An effective murine oral infection model for studying the pathogenesis of various clinical EV71 isolates is lacking. We developed a transgenic mouse that expresses EV71 receptor, that is human scavenger receptor class B member 2 (hSCARB2), in a pattern highly similar to that of murine endogenous mSCARB2 protein. Read More

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http://dx.doi.org/10.1128/JVI.00183-19DOI Listing
March 2019
1 Read

Foot-and-mouth disease virus antagonizes NOD2-mediated antiviral effects by inhibition of NOD2 protein expression.

J Virol 2019 Mar 20. Epub 2019 Mar 20.

State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Diseases Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China

The role of nucleotide-binding oligomerization domain 2 (NOD2) in foot-and-mouth disease virus (FMDV)-infected cells remains unknown. Here, we showed that FMDV infection activated NOD2-mediated IFN-β and NF-ĸB signaling pathways. NOD2 inhibited FMDV replication in the infected cells. Read More

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http://dx.doi.org/10.1128/JVI.00124-19DOI Listing

Immunogenicity and protective efficacy of recombinant proteins consisting of multiple epitopes of foot-and-mouth disease virus fused with flagellin.

Appl Microbiol Biotechnol 2019 Apr 19;103(8):3367-3379. Epub 2019 Mar 19.

State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot and Mouth Disease Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China.

Many recent studies have shown that flagellin fused to heterologous antigens can induce significantly enhanced humoral and cellular immune responses through its adjuvant activity. Therefore, in this study, two key B cell epitopes and a truncated VP1 (ΔVP1) protein from foot-and-mouth disease virus (FMDV) were expressed as flagellin fusion proteins in different patterns. Specifically, ΔVP1 and two duplicates of two key B cell epitopes (2×B1B2) were fused separately to the C-terminus of flagellin with a universal exogenous T cell epitope to construct FT (Flagellin-Truncated VP1) and FME (Flagellin-Multiple Epitopes). Read More

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http://dx.doi.org/10.1007/s00253-019-09691-5DOI Listing

Development of live attenuated Enterovirus 71 vaccine strains that confer protection against lethal challenge in mice.

Sci Rep 2019 Mar 18;9(1):4805. Epub 2019 Mar 18.

Centre for Virus and Vaccine Research, School of Science and Technology, Sunway University, Bandar Sunway, Selangor, 47500, Malaysia.

Besides causing mild hand, foot and mouth infections, Enterovirus A71 (EV-A71) is associated with neurological complications and fatality. With concerns about rising EV-A71 virulence, there is an urgency for more effective vaccines. The live attenuated vaccine (LAV) is a more valuable vaccine as it can elicit both humoral and cellular immune responses. Read More

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http://www.nature.com/articles/s41598-019-41285-z
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http://dx.doi.org/10.1038/s41598-019-41285-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423319PMC
March 2019
5 Reads

Infection Control in Nursery Schools and Schools Using a School Absenteeism Surveillance System.

Tohoku J Exp Med 2019 03;247(3):173-178

Infectious Disease Surveillance Center, National Institute of Infectious Diseases.

Infection control in nursery schools and schools is important for community health and the health of children. In Japan, caregivers of children or students usually report the absence due to illness to their attending nurseries or schools, including symptoms and diagnosed diseases. The (Nursery) School Absenteeism Surveillance System, (N)SASSy, covers about 60% of schools and 40% of nurseries in Japan. Read More

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https://www.jstage.jst.go.jp/article/tjem/247/3/247_173/_art
Publisher Site
http://dx.doi.org/10.1620/tjem.247.173DOI Listing
March 2019
7 Reads

Thermostability of the Foot-and-Mouth Disease Virus Capsid Is Modulated by Lethal and Viability-Restoring Compensatory Amino Acid Substitutions.

J Virol 2019 Mar 13. Epub 2019 Mar 13.

Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM), Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain

Infection by viruses depends on a balance between capsid stability and dynamics. This study has investigated biologically and biotechnologically relevant aspects of the relationship in foot-and-mouth disease virus (FMDV) between capsid structure and thermostability, and between thermostability and infectivity. In the FMDV capsid a substantial number of amino acid side chains at the interfaces between pentameric subunits are charged at neutral pH. Read More

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http://dx.doi.org/10.1128/JVI.02293-18DOI Listing

Essential role of enterovirus 2A protease in counteracting stress granule formation and the induction of type I interferon.

J Virol 2019 Mar 13. Epub 2019 Mar 13.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands

Most viruses have acquired mechanisms to suppress antiviral IFN-α/β and stress responses. Enteroviruses actively counteract the induction of IFN-α/β gene transcription and stress granule (SG) formation, which are increasingly implicated as a platform for antiviral signaling, but the underlying mechanisms remain poorly understood. Both viral proteases (2A and 3C) have been implicated to suppress these responses, but these conclusions predominantly rely on ectopic overexpression of viral proteases or addition of purified viral proteases to cell lysates. Read More

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http://dx.doi.org/10.1128/JVI.00222-19DOI Listing
March 2019
6 Reads

Reverse transcriptase droplet digital PCR to identify the emerging vesicular virus Senecavirus A in biological samples.

Transbound Emerg Dis 2019 Mar 12. Epub 2019 Mar 12.

Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Senecavirus A (SVA) belonging to the family Picornaviridae, genus Senecavirus was incidentally isolated in 2002 from the PER.C6 (transformed foetal retinoblast) cell line. However, currently, this virus is associated with vesicular disease in swine and it has been reported in countries such as the United States of America, Canada, China, Thailand and Colombia. Read More

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http://dx.doi.org/10.1111/tbed.13168DOI Listing
March 2019
2 Reads

APOBEC3G is a restriction factor of EV71 and mediator of IMB-Z antiviral activity.

Antiviral Res 2019 May 9;165:23-33. Epub 2019 Mar 9.

Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, 100050, China. Electronic address:

Enterovirus 71 (EV71), a single-stranded positive-sense RNA virus, is the causative agent of hand, foot, and mouth disease (HFMD), for which no effective antiviral therapy is currently available. Apolipoprotein B messenger RNA-editing enzyme catalytic polypeptide-like 3G (APOBEC3G or A3G) is a cytidine deaminase that inhibits the replication of several viruses, such as human immunodeficiency virus-1, hepatitis B virus and hepatitis C virus. In our efforts toward understanding the antiviral spectrum and mechanism of A3G, we found that ectopic expression of A3G inhibited EV71 replication, whereas knockdown of endogenous A3G expression promoted EV71 replication. Read More

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http://dx.doi.org/10.1016/j.antiviral.2019.03.005DOI Listing
May 2019
4 Reads
3.938 Impact Factor

Antiviral activity of sophoridine against enterovirus 71 in vitro.

J Ethnopharmacol 2019 May 7;236:124-128. Epub 2019 Mar 7.

Handan Municipal Center for Disease Control and Prevention, Hebei, 056000, China. Electronic address:

Ethnopharmacological Relevance: Enterovirus 71 (EV71) has a propensity to cause hand-foot-and-mouth disease (HFMD) epidemics associated with neurological sequelae. Unfortunately, no drugs are currently available for the clinical treatment of EV71 infections. Sophoridine (SRI) is one of the most abundant alkaloids in Sophora flavescens Aiton (Leguminosae), which has been used to treat fever, throat inflammation, cancer, and other diseases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03788741183483
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http://dx.doi.org/10.1016/j.jep.2019.02.045DOI Listing
May 2019
7 Reads

Efficient expression of enterovirus 71 based on virus-like particles vaccine.

PLoS One 2019 7;14(3):e0210477. Epub 2019 Mar 7.

Division of Vaccine Research, Center for Infectious Diseases, Korea National Institutes of Health, Korea Centers for Disease Control and Prevention, Osong-eup, Cheongju, Chungcheongbuk-do, Republic of Korea.

Enterovirus (EV) 71 is the main pathogen associated with hand-foot-mouth disease (HFMD) and can lead to the disease with severe mortality in children. Since 2009, in the Republic of Korea, an outbreak of EV71 C4a infection with neurologic involvement emerged, where in HFMD involvement was identified and central nervous system complications were reported. In this study, EV71 C4a virus-like particles (VLPs) produced by recombinant technology were generated in a baculovirus expression system. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210477PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405078PMC
March 2019
5 Reads

Combined Testing of p16 Tumour-suppressor Protein and Human Papillomavirus in Patients With Oral Leukoplakia and Oral Squamous Cell Carcinoma.

Anticancer Res 2019 Mar;39(3):1293-1300

Department of Oral Medicine and Pathology, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Background: Oral leukoplakia (OL) is a potentially malignant oral mucosal disorder. A casual association between OL, oral squamous cell carcinoma (OSCC) and human papillomavirus (HPV) infection has been suggested, but no conclusive evidence has been presented. p16, a tumour-suppressor protein, is used as a surrogate marker for HPV infection. Read More

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http://dx.doi.org/10.21873/anticanres.13241DOI Listing

Surgical removal for khat inducible verruca vulgaris lesion of the oral mucosa.

Authors:
G Gazal

Niger J Clin Pract 2019 Mar;22(3):439-441

Department of Maxillofacial Surgery, College of Dentistry, Taibah University, Al Madinah Al Munawwarah, Saudi Arabia.

The harmful effects of khat chewing on the oral mucosa membrane are still uncertain. Verruca vulgaris (common warts) is a benign lesion of skin and mucous membranes and can be caused by human papillomavirus. The lesions are typically self-limited but may vary in size and number. Read More

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http://dx.doi.org/10.4103/njcp.njcp_357_18DOI Listing

Efficient fecal-oral and possible vertical, but not respiratory, transmission of emerging Chlamydia gallinacea in broilers.

Vet Microbiol 2019 Mar 24;230:90-94. Epub 2019 Jan 24.

College of Veterinary Medicine, Yangzhou University Yangzhou, China; College of Veterinary Medicine, Auburn University, Auburn, AL, USA. Electronic address:

Chlamydia gallinacea is an endemic Chlamydia agent in poultry with a worldwide distribution. The aim of this study was to investigate whether C. gallinacea can be transmitted via fecal-oral, respiratory and vertical routes. Read More

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http://dx.doi.org/10.1016/j.vetmic.2019.01.018DOI Listing
March 2019
3 Reads

Genotypic and Phenotypic Diversity of Herpes Simplex Virus 2 within the Infected Neonatal Population.

mSphere 2019 02 27;4(1). Epub 2019 Feb 27.

Department of Biochemistry and Molecular Biology, Center for Infectious Disease Dynamics, The Huck Institutes of the Life Sciences, Pennsylvania State University, State College, Pennsylvania, USA

More than 14,000 neonates are infected with herpes simplex virus (HSV) annually. Approximately half display manifestations limited to the skin, eyes, or mouth (SEM disease). The rest develop invasive infections that spread to the central nervous system (CNS disease or encephalitis) or throughout the infected neonate (disseminated disease). Read More

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http://dx.doi.org/10.1128/mSphere.00590-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393728PMC
February 2019
3 Reads

Hsp27 Responds to and Facilitates Enterovirus A71 Replication by Enhancing Viral Internal Ribosome Entry Site-Mediated Translation.

J Virol 2019 May 17;93(9). Epub 2019 Apr 17.

Department of Biomedical Sciences, City University of Hong Kong, Kowloon, Hong Kong

Enterovirus 71 (EV-A71) is a human pathogen that causes hand, foot, and mouth disease (HFMD) and fatal neurological diseases, and no effective treatment is available. Characterization of key host factors is important for understanding its pathogenesis and developing antiviral drugs. Here we report that Hsp27 is one of the most upregulated proteins in response to EV-A71 infection, as revealed by two-dimensional gel electrophoresis-based proteomics studies. Read More

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http://jvi.asm.org/lookup/doi/10.1128/JVI.02322-18
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http://dx.doi.org/10.1128/JVI.02322-18DOI Listing
May 2019
9 Reads
4.439 Impact Factor

Immunogenicity and protective efficacy of a novel foot-and-mouth disease virus empty-capsid-like particle with improved acid stability.

Vaccine 2019 Mar 23;37(14):2016-2025. Epub 2019 Feb 23.

State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Grazing Animal Diseases of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Lanzhou, Gansu, China. Electronic address:

Foot-and-mouth disease virus (FMDV) is the etiological agent of a highly contagious disease that affects cloven-hoofed animal species. The FMDV capsid is highly acid labile and viral particles lose their immunogenicity when they disassemble at mildly acidic pHs. The viral capsid of FMDV serotype O is more sensitive than those of other serotypes, making it more difficult to acquire enough empty-capsid-like particles in the acidic insect cell environment for research. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.02.032DOI Listing
March 2019
1 Read

Inherent biophysical stability of foot-and-mouth disease SAT1, SAT2 and SAT3 viruses.

Virus Res 2019 Apr 23;264:45-55. Epub 2019 Feb 23.

Vaccine and Diagnostic Development Programme, Transboundary Animal Diseases, Onderstepoort Veterinary Institute, Agricultural Research Council, Private Bag X05, Onderstepoort, 0110, South Africa; Department of Biochemistry, Genetics and Microbiology, Faculty of Agricultural and Natural Sciences, University of Pretoria, Pretoria 0002, South Africa. Electronic address:

Foot-and-mouth disease (FMD) virus (FMDV) isolates show variation in their ability to withstand an increase in temperature. The FMDV is surprisingly thermolabile, even though this virus is probably subjected to a strong extracellular selective pressure by heat in hot climate regions where FMD is prevalent. The three SAT serotypes, with their particularly low biophysical stability also only yield vaccines of low protective capacity, even with multiple booster vaccinations. Read More

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http://dx.doi.org/10.1016/j.virusres.2019.02.012DOI Listing
April 2019
2 Reads
2.324 Impact Factor

Safety of Everolimus With Reduced Calcineurin Inhibitor Exposure in De Novo Kidney Transplants: An Analysis From the Randomized TRANSFORM Study.

Transplantation 2019 Feb 19. Epub 2019 Feb 19.

Renal Medicine, Royal Prince Alfred Hospital and University of Sydney, Australia.

Background: The safety profiles of standard therapy versus everolimus with reduced-exposure calcineurin inhibitor (CNI) therapy using contemporary protocols in de novo kidney transplant recipients have not been compared in detail.

Methods: TRANSFORM was a randomized, international trial in which de novo kidney transplant patients were randomized to everolimus with reduced-exposure CNI (N=1014) or mycophenolic acid (MPA) with standard-exposure CNI (N=1012), both with induction and corticosteroids.

Results: Within the safety population (everolimus 1014, MPA 1012), adverse events with a suspected relation to study drug occurred in 62. Read More

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http://dx.doi.org/10.1097/TP.0000000000002626DOI Listing
February 2019
3 Reads
3.828 Impact Factor

Rapidly assessing the risks of infectious diseases to wildlife species.

R Soc Open Sci 2019 Jan 16;6(1):181043. Epub 2019 Jan 16.

Royal Veterinary College, Hatfield, UK.

Predicting the likelihood of rare events is increasingly demanded by risk managers. A key challenge is dealing with different types of uncertainty, including epistemic uncertainties (lack of knowledge), stochasticity (inherent randomness) and natural variation. One potentially catastrophic event which is impacted by high levels of all three of these uncertainty types is the transmission of livestock pathogens to wildlife, particularly for endangered species. Read More

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http://dx.doi.org/10.1098/rsos.181043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366200PMC
January 2019

Hand, foot, and mouth disease associated with coxsackievirus A10: more serious than it seems.

Expert Rev Anti Infect Ther 2019 Apr 6;17(4):233-242. Epub 2019 Mar 6.

a Division of Hepatitis Virus Vaccines , National Institutes for Food and Drug Control , Beijing , China.

Introduction: Hand, foot, and mouth disease (HFMD) is a common viral childhood illness, that has been a severe public health concern worldwide, particularly in the Asia-Pacific region. According to epidemiological data of HFMD during the past decade, the most prevalent causal viruses were enterovirus (EV)-A71, coxsackievirus (CV)-A16, CV-A6, and CV-A10. The public health burden of CV-A10-related diseases has been underestimated as their incidence was lower than that of EV-A71 and CV-A16 in most HFMD outbreaks. Read More

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https://www.tandfonline.com/doi/full/10.1080/14787210.2019.1
Publisher Site
http://dx.doi.org/10.1080/14787210.2019.1585242DOI Listing
April 2019
10 Reads

Molecular epidemiology of an enterovirus A71 outbreak associated with severe neurological disease, Spain, 2016.

Euro Surveill 2019 Feb;24(7)

Translational Research Network in Paediatric Infectious Diseases (RITIP), IdiPaz, Madrid, Spain.

IntroductionEnterovirus A71 (EV-A71) is an emerging pathogen that causes a wide range of disorders including severe neurological manifestations. In the past 20 years, this virus has been associated with large outbreaks of hand, foot and mouth disease with neurological complications in the Asia-Pacific region, while in Europe mainly sporadic cases have been reported. In spring 2016, however, an EV-A71 outbreak associated with severe neurological cases was reported in Catalonia and spread further to other Spanish regions. Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2019.24.7.1800089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381658PMC
February 2019
6 Reads

Emergence of foot and mouth disease virus, Lib-12 lineage of topotype VII, serotype SAT2 in Egypt, 2018.

Transbound Emerg Dis 2019 Feb 18. Epub 2019 Feb 18.

Middle East for Veterinary vaccines (MEVAC), Salhea, Egypt.

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http://dx.doi.org/10.1111/tbed.13152DOI Listing
February 2019
2 Reads

Data fitting approach more critical than exposure scenarios and treatment of censored data for quantitative microbial risk assessment.

Water Res 2019 Feb 4;154:45-53. Epub 2019 Feb 4.

Instituto de Investigaciones para la Industria Química (INIQUI), CONICET, Universidad Nacional de Salta (UNSa), Av. Bolivia 5150, Salta, 4400, Argentina; Singapore Centre for Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, 637551, Singapore; Facultad de Ingeniería, UNSa, Salta, Argentina. Electronic address:

Recreational waters are a source of many diseases caused by human viral pathogens, including norovirus genogroup II (NoV GII) and enterovirus (EV). Water samples from the Arenales river in Salta, Argentina, were concentrated by ultrafiltration and analyzed for the concentrations of NoV GII and EV by quantitative PCR. Out of 65 samples, 61 and 59 were non-detects (below the Sample Limit of Detection limit, SLOD) for EV and NoV GII, respectively. Read More

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http://dx.doi.org/10.1016/j.watres.2019.01.041DOI Listing
February 2019
1 Read

Co-infection with different serotypes of FMDV in vaccinated cattle in Southern Egypt.

Virus Genes 2019 Feb 15. Epub 2019 Feb 15.

Center of Scientific Excellence for Influenza Viruses, Water Pollution Research Department, Environmental Research Division, National Research Centre (NRC), Egypt, Dokki, Giza, 12622, Egypt.

During 2015-2016 period, an outbreak of foot-and-mouth disease virus (FMDV) was observed in cattle in four governorates of the upper of Egypt. The infection was extended to the vaccinated cattle. A total of 54 mouth swabs and serum samples were collected from vaccinated cattle for serological and virological investigation. Read More

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http://dx.doi.org/10.1007/s11262-019-01645-3DOI Listing
February 2019
3 Reads
1.837 Impact Factor

Short-term effects of extreme meteorological factors on childhood hand, foot, and mouth disease reinfection in Hefei, China: A distributed lag non-linear analysis.

Sci Total Environ 2019 Feb 28;653:839-848. Epub 2018 Oct 28.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Shushan District, Hefei, Anhui 230032, China; Central Laboratory of Preventive Medicine, School of Public Health, Anhui Medical University, 81 Meishan Road, Shushan District, Hefei, Anhui 230032, China; Laboratory for environmental Toxicology, Anhui Medical University, 81 Meishan Road, Shushan District, Hefei, Anhui 230032, China. Electronic address:

Background: Hand, foot, and mouth disease (HFMD) is a major public health issue in China with a high burden of reinfection. Previous studies presented evidence of the relationship between meteorological factors and HFMD incidence, but no study examined the effects of extreme meteorological factors on HFMD reinfection.

Methods: Daily HFMD reinfection counts and meteorological data of Hefei city were collected from 2011 to 2016. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.10.349DOI Listing
February 2019
2 Reads

Opportunities for enhanced surveillance of foot-and-mouth disease in endemic settings using milk samples.

Transbound Emerg Dis 2019 Feb 10. Epub 2019 Feb 10.

Boyd Orr Centre for Population and Ecosystem Health, Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

Under-reporting of foot-and-mouth disease (FMD) masks the true prevalence in parts of the world where the disease is endemic. Laboratory testing for the detection of FMD virus (FMDV) is usually reliant upon the collection of vesicular epithelium and fluid samples that can only be collected from acutely infected animals, and therefore animals with sub-clinical infection may not be identified. Milk is a non-invasive sample type routinely collected from dairy farms that has been utilized for surveillance of a number of other diseases. Read More

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http://dx.doi.org/10.1111/tbed.13146DOI Listing
February 2019
7 Reads

Application of a combined model with seasonal autoregressive integrated moving average and support vector regression in forecasting hand-foot-mouth disease incidence in Wuhan, China.

Medicine (Baltimore) 2019 Feb;98(6):e14195

Wuhan Centers for Disease Prevention and Control.

Hand-foot-mouth disease (HFMD) is a serious public health problem with increasing cases and substantial financial burden in China, especially in Wuhan city. Hence, there is an urgent need to construct a model to predict the incidence of HFMD that could make the prevention and control of this disease more effective.The incidence data of HFMD of Wuhan city from January 2009 to December 2016 were used to fit a combined model with seasonal autoregressive integrated moving average (SARIMA) model and support vector regression (SVR) model. Read More

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http://dx.doi.org/10.1097/MD.0000000000014195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380825PMC
February 2019
1 Read

Development of a New RT-PCR with Multiple Primers for Detecting Southern African Territories Foot-and-mouth Disease Viruses.

J Vet Res 2018 Dec 31;62(4):431-437. Epub 2018 Dec 31.

State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, Gansu, China.

Introduction: The extremely high genetic variation and the continuously emerging variants of foot-and-mouth disease virus (FMDV) of Southern African Territory (SAT) serotypes including SAT1, SAT2, and SAT3 make it necessary to develop a new RT-PCR for general use for monitoring viruses based on the updated genome information.

Material And Methods: A FMDV SAT-D8 one-step RT-PCR was established based on the 1D2A2B genes of the SAT serotype viruses with a multiplex primer set. FMDV A, O, C, and Asia 1 serotypes, other vesicular disease viruses, inactivated SAT viruses, and 125 bovine, ovine, caprine and porcine tissue samples collected from the Chinese mainland were included for evaluating the assay. Read More

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http://dx.doi.org/10.2478/jvetres-2018-0064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364153PMC
December 2018
3 Reads

The Pseudoknot Region of the 5' Untranslated Region Is a Determinant of Viral Tropism and Virulence of Foot-and-Mouth Disease Virus.

J Virol 2019 Apr 3;93(8). Epub 2019 Apr 3.

State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Diseases Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

Foot-and-mouth disease virus (FMDV) is the causative agent of foot-and-mouth disease. It is characterized by genetic instability and different antigenic properties. The nonstructural protein 3A is a primary determinant of the tropism and virulence of Cathay topotype FMDVs. Read More

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http://dx.doi.org/10.1128/JVI.02039-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450104PMC
April 2019
4 Reads

Prenatal exposure to perfluoroalkyl substances is associated with lower hand, foot and mouth disease viruses antibody response in infancy: Findings from the Guangzhou Birth Cohort Study.

Sci Total Environ 2019 May 26;663:60-67. Epub 2019 Jan 26.

Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address:

Background: Perfluoroalkyl substances (PFASs) are synthetic chemicals widely used in industry and for commercial products. Their immunomodulatory effects are a growing health concern in children. Hand, Foot and Mouth Disease (HFMD) is a common childhood viral infection, and increased incidence of which has parallel the rise in PFAS exposure in the Asia-Pacific region. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.01.325DOI Listing
May 2019
2 Reads

Letter to the editor about the classification of recently emerged foot-and-mouth disease virus O/ME-SA/Ind2001 sublineages concerning two published articles in Transboundary and Emerging Diseases.

Transbound Emerg Dis 2019 03 1;66(2):1093-1094. Epub 2019 Feb 1.

Department of Microbiology, University of Dhaka, Dhaka, Bangladesh.

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http://dx.doi.org/10.1111/tbed.13054DOI Listing
March 2019
2.944 Impact Factor

Response to comment on "First detection of foot-and-mouth disease virus O/ME-SA/Ind2001 in China".

Transbound Emerg Dis 2019 03 1;66(2):1095-1096. Epub 2019 Feb 1.

State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Diseases Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China.

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http://dx.doi.org/10.1111/tbed.13052DOI Listing
March 2019
2 Reads

Foot-and-mouth disease virus O/ME-SA/Ind 2001 lineage outbreak in vaccinated Holstein Friesian cattle in Saudi Arabia in 2016.

Vet Q 2018 12;38(1):88-98

e Department of Pathology, College of Veterinary medicine , King Faisal University , Saudi Arabia.

Background: Foot-and-mouth disease virus (FMDV) is a highly contagious viral infection of large ruminants. Despite the massive application of vaccines against FMDV, several outbreaks are still being reported in Africa and Asia.

Aim: To perform molecular characterization of FMDV in an outbreak among a cattle herd Saudi Arabia in 2016. Read More

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http://dx.doi.org/10.1080/01652176.2018.1539568DOI Listing
December 2018
1 Read
0.652 Impact Factor

Development of a multiplex TaqMan qPCR assay for simultaneous detection and differentiation of four DNA and RNA viruses from clinical samples of sheep and goats.

J Virol Methods 2019 Apr 28;266:58-64. Epub 2019 Jan 28.

College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, China. Electronic address:

Mixed infections with different pathogens are common in sheep and goats under intensive production conditions. Quick and accurate detection and differentiation of different pathogens is necessary for epidemiological surveillance, disease management and import and export controls. Multiplex TaqMan qPCR protocols were developed and subsequently evaluated as effective tools in simultaneously detecting single and mixed infections in sheep and goats. Read More

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http://dx.doi.org/10.1016/j.jviromet.2019.01.015DOI Listing
April 2019
2 Reads
1.883 Impact Factor

Ramsay Hunt syndrome with pontine lesion: A case report.

Medicine (Baltimore) 2019 Feb;98(5):e14260

Department of Neurological Function Examination.

Rationale: The coexistence of Ramsay Hunt syndrome (RHS) and varicella-zoster virus (VZV) encephalitis is rare. A patient who developed RHS after being infected with VZV, along with a pontine lesion, is reported in the present study.

Patient Concerns: A 41-year-old male patient presented with his mouth askew for 7 days, and dizziness, accompanied by hearing loss for 3 days. Read More

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http://dx.doi.org/10.1097/MD.0000000000014260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380842PMC
February 2019
9 Reads
5.723 Impact Factor

Dissecting Flavivirus Biology in Salivary Gland Cultures from Fed and Unfed (Black-Legged Tick).

MBio 2019 01 29;10(1). Epub 2019 Jan 29.

Biology of Vector-Borne Viruses Section, Laboratory of Virology, Rocky Mountain Laboratories, NIAID/NIH, Hamilton, Montana, USA.

The tick transmits a number of pathogens, including tick-borne flaviviruses (TBFVs). In the United States, confirmed human infections with the Powassan virus (POWV) TBFV have a fatality rate of ∼10% and are increasing in incidence. Tick salivary glands (SGs) serve as an organ barrier to TBFV transmission, and little is known regarding the location of TBFV infection in SGs from fed ticks. Read More

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http://dx.doi.org/10.1128/mBio.02628-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355982PMC
January 2019
5 Reads
6.786 Impact Factor

PADI-web corpus: Labeled textual data in animal health domain.

Data Brief 2019 Feb 23;22:643-646. Epub 2018 Dec 23.

TETIS, Univ. of Montpellier, AgroParisTech, Cirad, CNRS, Irstea, Montpellier, France.

Monitoring animal health worldwide, especially the early detection of outbreaks of emerging pathogens, is one of the means of preventing the introduction of infectious diseases in countries (Collier et al., 2008) [3]. In this context, we developed PADI-web, a Platform for Automated extraction of animal Disease Information from the Web (Arsevska et al. Read More

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http://dx.doi.org/10.1016/j.dib.2018.12.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327737PMC
February 2019
1 Read