14,474 results match your criteria Viral Infections of the Mouth


Towards Understanding Liposome-Based siRNA Delivery Vectors: Atomic-Scale Insight into siRNA-Lipid Interactions.

Langmuir 2018 Jun 22. Epub 2018 Jun 22.

Liposome carriers for delivering small interfering RNA (siRNA) into target cells are of tremendous importance because the siRNA-based therapy offers a completely new approach for treating a wide range of diseases, including cancer and viral infections. In this paper we employ the state-of-the-art computer simulations to get an atomic-scale insight into the interactions of siRNA with zwitterionic (neutral) lipids. Our computational findings clearly demonstrate that siRNA does adsorb on the surface of a neutral lipid bilayer. Read More

View Article

Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

J Periodontol 2018 Jun;89 Suppl 1:S74-S84

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

View Article

Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

View Article

An improved, rapid competitive ELISA using a novel conserved 3B epitope for the detection of serum antibodies to foot-and-mouth disease virus.

J Vet Diagn Invest 2018 Jun 1:1040638718779641. Epub 2018 Jun 1.

U.S. Department of Homeland Security Science & Technology Directorate (Chung).

The highly contagious foot-and-mouth disease virus (FMDV) afflicts cloven-hoofed animals, resulting in significant costs because of loss of trade and recovery from disease. We developed a sensitive, specific, and rapid competitive ELISA (cELISA) to detect serum antibodies to FMDV. The cELISA utilized a monoclonal blocking antibody specific for a highly conserved FMDV nonstructural 3B epitope, a recombinant mutant FMDV 3ABC coating protein, and optimized format variables including serum incubation for 90 min at 20-25°C. Read More

View Article
June 2018
1 Read

The protective capacity of high payload FMDV A22 IRQ vaccine in sheep against direct-contact challenge with a heterologous, contemporary FMDV A strain from South East Asia.

PLoS One 2018 18;13(6):e0195302. Epub 2018 Jun 18.

Australian Animal Health Laboratory, CSIRO, Geelong, Victoria, Australia.

Foot-and-mouth disease (FMD) is an acute, highly contagious viral disease of domestic and wild cloven-hoofed animals, caused by FMD virus (FMDV). An FMD outbreak can cause major production losses and have significant implications for trade. Vaccination can assist in controlling the disease, and emergency vaccination using high antigen payload vaccines (>6 PD50/dose) is considered an important control approach in the event of an outbreak. Read More

View Article
June 2018
2 Reads

Foot-and-mouth disease virus nonstructural protein 2B interacts with cyclophilin A, modulating virus replication.

FASEB J 2018 Jun 15:fj201701351. Epub 2018 Jun 15.

State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Diseases Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.

Foot-and-mouth disease (FMD) is a highly contagious virus that affects cloven-hoofed animals. To understand better the role of nonstructural protein 2B of the causative agent FMD virus (FMDV) in the process of virus replication, we identified a porcine host protein, cyclophilin A (CypA), which interacts with FMDV 2B. The 2B-CypA interaction was confirmed by coimmunoprecipitation and GST pull-down assays. Read More

View Article

Foot-and-Mouth Disease Virus Counteracts on Internal Ribosome Entry Site Suppression by G3BP1 and Inhibits G3BP1-Mediated Stress Granule Assembly Post-Translational Mechanisms.

Front Immunol 2018 25;9:1142. Epub 2018 May 25.

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.

Foot-and-mouth disease (FMD) is a highly contagious, severe viral illness notifiable to the World Organization for Animal Health. The causative agent, FMD virus (FMDV), replicates rapidly and efficiently inhibits host translation and the innate immune response for it has developed multiple tactics to evade host defenses and takes over gene expression machinery in the host cell. Here, we report a systemic analysis of the proteome and phosphoproteome of FMDV-infected cells. Read More

View Article
May 2018
4 Reads

Comparison of Herpes Simplex Virus PCR with Culture for Virus Detection in Multisource Surface Swab Specimens from Neonates.

J Clin Microbiol 2018 Jun 6. Epub 2018 Jun 6.

Children's Hospital Colorado, Department of Pathology and Laboratory Medicine. 13123 E 16 Ave, Aurora, Colorado 80045, USA.

The American Academy of Pediatrics currently recommends herpes simplex virus (HSV) culture over PCR for testing of swabs of the conjunctivae, mouth, nasopharynx, and rectum (surface swabs) in neonates. To compare the performance and time to results of HSV PCR with HSV culture in surface swabs from neonates. Banked multisource surface samples that had previously been cultured for HSV from infants less than or equal to 30 days old collected from January 2017 to December 2017 were identified and tested retrospectively by HSV PCR. Read More

View Article
June 2018
2 Reads

Review of Seneca Valley Virus: A Call for Increased Surveillance and Research.

Front Microbiol 2018 11;9:940. Epub 2018 May 11.

State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Diseases Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.

Seneca Valley virus (SVV) has recently caused many vesicular diseases in pigs in different regions and countries. As a newly causative agent of porcine vesicular disease, SVV has evolved and spread quickly. It causes clinical signs similar to those of foot-and-mouth disease and results in significant economic losses. Read More

View Article

VP1 amino acid residue 145 of enterovirus 71 is a key residue for its receptor attachment and resistance to neutralizing antibody during cynomolgus monkey infection.

J Virol 2018 May 30. Epub 2018 May 30.

Neurovirology Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan

Enterovirus 71 (EV71) is a causative agent of hand, foot, and mouth disease and sometimes causes severe or fatal neurological complications. The amino acid at VP1-145 determines virological characteristics of EV71. Viruses with glutamic acid (E) at VP1-145 (VP1-145E) are virulent in neonatal mice and transgenic mice expressing human scavenger receptor B2, whereas those with glutamine (Q) or glycine (G) are not. Read More

View Article

The program of antiviral agents inhibits virus infection.

Arch Microbiol 2018 May 30. Epub 2018 May 30.

State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, Gansu, China.

Virus infections are the root cause of epidemics in the world. Vaccines and antiviral agents have been the two important methods to control viral diseases; in recent times, RNA-mediated therapeutics and prevention have received much attention. In this review, we provide an overview of the current information regarding the use of vaccines, antiviral agents, and RNA-mediated methods in controlling or preventing viral infections. Read More

View Article

Carotid aneurysms: unusual referrals from general dental practice.

Br Dent J 2018 May;224(10):777-778

Oral and Maxillofacial Department, Morriston Hospital.

Oral and maxillofacial surgeons carry out the diagnosis and treatment of diseases affecting the mouth, jaws, face and neck. They provide a critical referral service for dentists in general practice, with the most suspicious of these being sent as 'urgent suspected cancer', or 'USC'. According to national guidelines, such cases must be seen within 14 days. Read More

View Article

Design and Efficacy of Nanogels Formulations for Intranasal Administration.

Molecules 2018 May 23;23(6). Epub 2018 May 23.

Department of Chemistry, University of Fort Hare, Alice Campus, Eastern Cape 5700, South Africa.

Nanogels are drug delivery systems that can bypass the blood-brain barrier and deliver drugs to the desired site when administered intranasally. They have been used as a drug delivery platform for the management of brain diseases such as Alzheimer disease, migraine, schizophrenia and depression. nanogels have also been developed as vaccine carriers for the protection of bacterial infections such as influenza, meningitis, pneumonia and as veterinary vaccine carriers for the protection of animals from encephalomyelitis and mouth to foot disease. Read More

View Article

Effect of vaccination on cattle subclinically infected with foot-and-mouth disease virus in Cameroon.

Prev Vet Med 2018 Jul 5;155:1-10. Epub 2018 Apr 5.

USDA/ARS Foreign Animal Disease Research Unit, Plum Island Animal Disease Center, P.O. Box 848, Greenport, NY, USA. Electronic address:

Foot-and-mouth disease (FMD) is one of the most contagious and economically important livestock diseases worldwide. Four serotypes of FMD virus (FMDV; O, A, SAT1, SAT2) circulate in Cameroon, and a trivalent inactivated vaccine against the three most common serotypes (O, A, SAT2) was recently introduced in 2014. The objective of this study was to characterize vaccine performance in cattle under natural hyperendemic conditions in the Adamawa region of Cameroon. Read More

View Article

Acyclovir lipid nanocapsules gel for oromucosal delivery: A preclinical evidence of efficacy in the chicken pouch membrane model.

Eur J Pharm Sci 2018 May 18;121:228-235. Epub 2018 May 18.

Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt. Electronic address:

The study aimed to develop a patient-friendly acyclovir gel with improved efficacy in viral mouth infections, in response to patients' need for an intraoral acyclovir product. Acyclovir was loaded in lipid nanocapsules in gel form, and formulae were evaluated for oromucosal delivery. Lipid nanocapsules were prepared by the phase inversion method. Read More

View Article
May 2018
3 Reads

Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus.

Nat Chem 2018 Jun 14;10(6):599-606. Epub 2018 May 14.

Department of Chemistry, Imperial College London, London, UK.

Rhinoviruses (RVs) are the pathogens most often responsible for the common cold, and are a frequent cause of exacerbations in asthma, chronic obstructive pulmonary disease and cystic fibrosis. Here we report the discovery of IMP-1088, a picomolar dual inhibitor of the human N-myristoyltransferases NMT1 and NMT2, and use it to demonstrate that pharmacological inhibition of host-cell N-myristoylation rapidly and completely prevents rhinoviral replication without inducing cytotoxicity. The identification of cooperative binding between weak-binding fragments led to rapid inhibitor optimization through fragment reconstruction, structure-guided fragment linking and conformational control over linker geometry. Read More

View Article
June 2018
1 Read

Rapid detection of hand, foot and mouth disease enterovirus genotypes by multiplex PCR.

J Virol Methods 2018 08 26;258:7-12. Epub 2018 May 26.

Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Taishan Medical College, Taian, 271000, Shandong, China. Electronic address:

Hand, foot and mouth disease (HFMD) is a pediatric disease associated with infection by enterovirus (EV) genotypes. The major HFMD EV pathogens are enterovirus A71 (EVA71) and coxsackievirus A16 (CVA16); however, recently, coxsackievirus A6 (CVA6) and coxsackievirus A10 (CVA10) have also emerged. EV genotypes cannot be distinguished on clinical grounds and a new methodology for the rapid detection of the four major HFMD EV genotypes is urgently required. Read More

View Article
August 2018
2 Reads

Assessing Biosecurity Risks for the Introduction and Spread of Diseases Among Commercial Sheep Properties in New South Wales, Australia, Using Foot-and-Mouth Disease as a Case Study.

Front Vet Sci 2018 17;5:80. Epub 2018 Apr 17.

Graham Centre for Agricultural Innovation (an alliance between Charles Sturt University and NSW Department of Primary Industries), Wagga Wagga, NSW, Australia.

Sheep production systems are a major industry in Australia, with a gross value of roughly $4.66 billion; 87.3% of which is attributable to export markets. Read More

View Article

Development of gold nanoparticles biosensor for ultrasensitive diagnosis of foot and mouth disease virus.

J Nanobiotechnology 2018 May 11;16(1):48. Epub 2018 May 11.

Department of Biosciences and Technology for Food, Agriculture and Environment, University of Teramo, 64023, Teramo, Italy.

Background: Nano-PCR is a recent tool that is used in viral diseases diagnosis. The technique depends on the fundamental effects of gold nanoparticles (AuNPs) and is considered a very effective and sensitive tool in the diagnosis of different diseases including viral diseases. Although several techniques are currently available to diagnose foot and mouth disease virus (FMDV), a highly sensitive, highly specific technique is needed for specific diagnosis of the disease. Read More

View Article

Enterovirus and Parechovirus Surveillance - United States, 2014-2016.

MMWR Morb Mortal Wkly Rep 2018 May 11;67(18):515-518. Epub 2018 May 11.

Division of Viral Diseases, National Center for Immunization and Respiratory Disease, CDC.

Infections caused by enteroviruses (EV) and parechoviruses (PeV), members of the Picornaviridae family, are associated with various clinical manifestations, including hand, foot, and mouth disease; respiratory illness; myocarditis; meningitis; and sepsis; and can result in death. The genus Enterovirus includes four species of enterovirus (A-D) known to infect humans, and the genus Parechovirus includes one species (A) that infects humans. These species are further divided into types, some of which are associated with specific clinical manifestations. Read More

View Article
May 2018
1 Read

First detection of foot-and-mouth disease virus O/ME-SA/Ind2001 in China.

Transbound Emerg Dis 2018 May 9. Epub 2018 May 9.

State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Diseases Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China.

Foot-and-mouth disease (FMD) is endemic in China and is predominantly due to foot-and-mouth disease virus (FMDV) serotype O Mya-98 lineage. In recent years, FMDV O/ME-SA/Ind2001 lineage has spread from the Indian subcontinent to South-East Asia, Middle East and Africa, which may pose potential threats for future trans-regional livestock movements. In this study, we identified the appearance of FMDV O/ME-SA/Ind2001 in China; the first time that this virus lineage has been found there. Read More

View Article

study on role of σB protein in avian reovirus pathogenesis.

Oncotarget 2018 Apr 13;9(28):19569-19583. Epub 2018 Apr 13.

Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, India.

Avian reoviruses, members of genus was known to cause diseases like tenosynovitis, runting-stunting syndrome in chickens. Among eight structural proteins, the proteins of S-class are mainly associated with viral arthritis but the significance of σB protein in arthritis is not established till date. In this infection pathological condition together with infection of joints often leads to arthritis because joints consists of cartilage which forms lubricating surface between two bones, and has limited metabolic, replicative and repair capacity. Read More

View Article
April 2018
3 Reads

Central Nervous System B-cell Lymphoma in a Bald Eagle ( Haliaeetus leucocephalus).

J Avian Med Surg 2018 Mar;32(1):40-44

An adult bald eagle ( Haliaeetus leucocephalus) presented for nystagmus and an inability to fly. On physical examination, the eagle was open-mouth breathing and tachycardic at 200 beats per minute, had a wrinkled cere and sunken eyes, and was an estimated 10% dehydrated. Additionally, the eagle was extremely weak, with neurologic abnormalities including bilateral proprioceptive deficits, nystagmus, and no pupillary light reflex in the left eye. Read More

View Article
March 2018
1 Read

Managing complexity: Simplifying assumptions of foot-and-mouth disease models for swine.

Transbound Emerg Dis 2018 Apr 23. Epub 2018 Apr 23.

Department of Veterinary Population Medicine, University of Minnesota, St. Paul, MN, USA.

Compartmental models have often been used to test the effectiveness and efficiency of alternative control strategies to mitigate the spread of infectious animal diseases. A fundamental principle of epidemiological modelling is that models should start as simple as possible and become as complex as needed. The simplest version of a compartmental model assumes that the population is closed, void of births and deaths and that this closed population mixes homogeneously, meaning that each infected individual has an equal probability of coming into contact with each susceptible individual in the population. Read More

View Article

Detection of hand-foot-mouth disease and its spatial-temporal Epidemiological characteristics with GIS platform.

J Biol Regul Homeost Agents 2018 Mar-Apr;32(2):371-377

Information and Management School, Guangxi Medical University, Nanning, Guangxi, China.

The aim of this study is to investigate the main category of hand-foot-mouth (HFM) virus and analyze the distribution characteristics and susceptible population of HFM disease in China. Infants who have had HFM disease for less than 7 days were selected from the First Affiliated Hospital of Guangxi Medical University, Guangxi, China. Various specimens were collected from the infants, and EV71 and CA16 nucleic acid detections were performed using fluorescence quantitative assay. Read More

View Article

Review: Risks of disease transmission through semen in cattle.

Authors:
M D Givens

Animal 2018 Jun 18;12(s1):s165-s171. Epub 2018 Apr 18.

1College of Veterinary Medicine,Auburn University,Auburn,AL 36849-5536,USA.

The purpose of this paper is to review scientific evidence concerning pathogens that could potentially be transmitted via bovine semen. As a result of a careful analysis of the characteristics of infections that may cause transmission of disease through semen, effective control procedures can be identified that provide minimal constraint to the introduction of new bulls into herds for natural breeding and importation of valuable novel genetics through artificial insemination. The potential for transmission through bovine semen and corresponding effective control procedures are described for bovine herpesvirus 1, bovine viral diarrhea virus, bovine leukemia virus, lumpy skin disease virus, bluetongue virus, foot-and-mouth disease virus, and Schmallenberg virus. Read More

View Article
June 2018
1 Read

Enterovirus serotypes in patients with central nervous system and respiratory infections in Viet Nam 1997-2010.

Virol J 2018 04 12;15(1):69. Epub 2018 Apr 12.

Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam.

Background: Enteroviruses are the most common causative agents of human illness. Enteroviruses have been associated with regional and global epidemics, recently, including with severe disease (Enterovirus A71 and D68), and are of interest as emerging viruses. Here, we typed Enterovirus A-D (EV) from central nervous system (CNS) and respiratory infections in Viet Nam. Read More

View Article
April 2018
3 Reads

From HSV infection to erythema multiforme through autoimmune crossreactivity.

Authors:
Alberta Lucchese

Autoimmun Rev 2018 Jun 7;17(6):576-581. Epub 2018 Apr 7.

Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania 'Luigi Vanvitelli', Via de Crecchio 6, 80138 Naples, Italy. Electronic address:

Scientific and clinical data indicate that human herpes simplex virus 1 (HSV1) and, at a lesser extent, human herpes simplex virus 2 (HSV2) are factor(s) implicated in the development of erythema multiforme (EM). With a focus on oral EM, the present structured review of proteomic and epitope databases searched for the molecular basis that might link HSV1 and HSV2 infections to EM. It was found that a high number of peptides are shared between the two HSVs and human proteins related to the oral mucosa. Read More

View Article
June 2018
2 Reads

History of Foot-and-mouth disease in North African countries.

Vet Ital 2018 Mar;54(1):1-12

Ecole Superieure en Science de l'Aliment et des Industries Agroalimentaire (ESSAIA), 01 Avenue Hamidouche El-Harrach, Algiers.

Foot-and-mouth disease (FMD) is a highly infectious and contagious transboundary viral disease of domesticated and wild cloven-hoofed animals. Wide prevalence of FMD in Asia and Africa associated with huge economic losses to livestock farming and industry prompted global concern. The present review summarizes the state of the art research in epidemiology, diagnosis, and surveillance of FMD in the North African countries. Read More

View Article
March 2018
4 Reads

The life cycle of non-polio enteroviruses and how to target it.

Nat Rev Microbiol 2018 Jun;16(6):368-381

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.

The genus Enterovirus (EV) of the family Picornaviridae includes poliovirus, coxsackieviruses, echoviruses, numbered enteroviruses and rhinoviruses. These diverse viruses cause a variety of diseases, including non-specific febrile illness, hand-foot-and-mouth disease, neonatal sepsis-like disease, encephalitis, paralysis and respiratory diseases. In recent years, several non-polio enteroviruses (NPEVs) have emerged as serious public health concerns. Read More

View Article
June 2018
12 Reads

Need for speed: An optimized gridding approach for spatially explicit disease simulations.

PLoS Comput Biol 2018 04 6;14(4):e1006086. Epub 2018 Apr 6.

Department of Physics, Chemistry and Biology, Division of Theoretical Biology, Linköping University, Linköping, Sweden.

Numerical models for simulating outbreaks of infectious diseases are powerful tools for informing surveillance and control strategy decisions. However, large-scale spatially explicit models can be limited by the amount of computational resources they require, which poses a problem when multiple scenarios need to be explored to provide policy recommendations. We introduce an easily implemented method that can reduce computation time in a standard Susceptible-Exposed-Infectious-Removed (SEIR) model without introducing any further approximations or truncations. Read More

View Article

Antiviral activity of porcine interferon delta 8 against foot-and-mouth disease virus in vitro.

Int Immunopharmacol 2018 Jun 3;59:47-52. Epub 2018 Apr 3.

State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, Gansu, PR China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu Province 225009, PR China. Electronic address:

Foot-and-mouth disease (FMD) is one of the most devastating diseases affecting livestock. Since vaccines fail to provide protection until seven days post-vaccination, the application of anti-viral molecules is imperative for suppressing the spread of FMDV prior to development of an adaptive immune response. Interferons (IFNs) are effective for the host to fight FMDV infections; however, a novel type I IFNs, interferon delta (IFN-δ), has not been investigated for their antiviral effects against this virus. Read More

View Article
June 2018
1 Read

Hand, Foot, and Mouth Disease in an Adult.

N Engl J Med 2018 Apr;378(14):e20

Nagoya University Graduate School of Medicine, Nagoya, Japan

View Article
April 2018
1 Read

[Epidemiological characteristics of Coxsackie virus A16 caused hand foot and mouth disease cases in Guangdong province, 2012-2016].

Zhonghua Liu Xing Bing Xue Za Zhi 2018 Mar;39(3):342-346

Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.

To analyze the epidemiological characteristics of hand foot and mouth disease (HFMD) cases caused by Coxsackie virus A16 (Cox A16) in Guangdong province from 2012 to 2016. The data of mild HFMD cases caused by Cox A16 were collected from 8 sentinel hospitals in 8 prefecture-level cities in Guangdong to estimate Cox A16 infection status and its population and time distribution characteristics. (1) The highest estimated incidence of Cox A16 infection was in 2014 (113. Read More

View Article

Lymphocytic focus score is positively related to airway and interstitial lung diseases in primary Sjögren's syndrome.

Respir Med 2018 Apr 1;137:95-102. Epub 2018 Mar 1.

Department of Respiratory Medicine, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Objective: Although high-resolution computed tomography (HRCT) is useful for the characterization of minute morphological changes in the lungs, no study has investigated risk factors for lung involvement detected by HRCT in patients with Sjögren's syndrome with or without respiratory symptoms. The aim of the current study was to investigate risk factors for lung involvement in patients with primary Sjögren's syndrome detected by HRCT, with a particular focus on airway and interstitial lung diseases.

Methods: We performed a retrospective cohort study of patients with primary Sjögren's syndrome and investigated risk factors for lung involvement detected by HRCT. Read More

View Article
April 2018
2 Reads

Isolation, molecular characterization and sero-prevalence study of foot-and-mouth disease virus circulating in central Ethiopia.

BMC Vet Res 2018 Mar 27;14(1):110. Epub 2018 Mar 27.

National Animal Health Diagnostics and Investigation Center, P.O.Box 04, Sebeta, Ethiopia.

Background: Ethiopian livestock production and productivity is still very low due to widespread of diseases. Among the diseases, foot-and-mouth disease (FMD) is an extremely contagious and acute viral disease that causes significant economic problems in the country. A cross sectional study design was conducted from September 2015 to May 2016 to isolate and characterize FMD virus from outbreak cases; determine the sero-prevalence of antibodies against FMD virus (FMDV), and assess potential risk factors associated with sero-prevalence of the disease in selected areas of central Ethiopia. Read More

View Article
March 2018
2 Reads

An emerging and expanding clade accounts for the persistent outbreak of Coxsackievirus A6-associated hand, foot, and mouth disease in China since 2013.

Virology 2018 05 26;518:328-334. Epub 2018 Mar 26.

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Xiamen University, Xiang'an Campus of Xiamen University, South Xiang'an Rd., Xiamen, China; National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiang'an Campus of Xiamen University, South Xiang'an Rd., Xiamen, China; School of Public Health, Xiamen University, Xiang'an Campus of Xiamen University, South Xiang'an Rd., Xiamen, China. Electronic address:

Enterovirus (EV)-A71 and Coxsackievirus (CV)-A16 have historically been the major pathogens of hand, foot, and mouth disease (HMFD) in China; however, CV-A6, which had previously received little attention, became the predominant pathogen in 2013, and has remained one of the common pathogens since then. In this work, we conducted a molecular epidemiology study of CV-A6-associated HFMD in Xiamen from 2009 to 2015. The data showed CV-A6 pandemics had a certain periodicity rather than occurring randomly. Read More

View Article
May 2018
2 Reads

The phylogenetic analysis of VP1 genomic region in foot-and-mouth disease virus serotype O isolates in Sri Lanka reveals the existence of 'Srl-97', a newly named endemic lineage.

PLoS One 2018 23;13(3):e0194077. Epub 2018 Mar 23.

Postgraduate Institute of Science, University of Peradeniya, Peradeniya, Sri Lanka.

Foot and mouth disease (FMD) has devastated the cattle industry in Sri Lanka many times in the past. Despite its seriousness, limited attempts have been made to understand the disease to ameliorate its effects-current recommendation for vaccines being based solely on immunological assessments rather than on molecular identification. The general belief is that the cattle population in Sri Lanka acquired the FMD virus (FMDV) strains via introductions from India. Read More

View Article

Case 9-2018: A 55-Year-Old Man with HIV Infection and a Mass on the Right Side of the Face.

N Engl J Med 2018 Mar;378(12):1143-1152

From the Departments of Medicine (K.L.A., R.T.G.), Radiology (H.R.K.), and Pathology (A.L.), Massachusetts General Hospital, the Departments of Medicine (K.L.A., R.T.G.), Radiology (H.R.K.), and Pathology (A.L.), Harvard Medical School, and the Department of Radiology, Massachusetts Eye and Ear (H.R.K.) - all in Boston.

View Article

Rabies in the Americas: 1998-2014.

PLoS Negl Trop Dis 2018 03 20;12(3):e0006271. Epub 2018 Mar 20.

Zoonosis group, Pan American Foot-and-Mouth Disease Center (PANAFTOSA), Pan American Health Organization (PAHO/WHO), Rio de Janeiro, Brazil.

Through national efforts and regional cooperation under the umbrella of the Regional Program for the Elimination of Rabies, dog and human rabies have decreased significantly in Latin America and Caribbean (LAC) countries over the last three decades. To achieve this decline, LAC countries had to develop national plans, and consolidate capabilities such as regular mass dog vaccination, opportune post-exposure prophylaxis and sensitive surveillance. This paper presents longitudinal data for 21 LAC countries on dog vaccination, PEP and rabies surveillance collected from the biannual regional meeting for rabies directors from 1998-2014 and from the Regional Epidemiologic Surveillance System for Rabies (SIRVERA). Read More

View Article
March 2018
1 Read

A canine adenovirus type 2 vaccine vector confers protection against foot-and-mouth disease in guinea pigs.

Vaccine 2018 04 12;36(16):2193-2198. Epub 2018 Mar 12.

UMR Virologie, INRA, ANSES, École Nationale Vétérinaire d'Alfort, Maisons-Alfort, F-94700, France. Electronic address:

Vaccination is a key element in the control of foot-and-mouth disease (FMD). The majority of the antigenic sites that induce protective immune responses are localized on the FMD virus (FMDV) capsid that is formed by four virus-encoded structural proteins, VP1 to VP4. In the present study, recombinant canine adenovirus type 2 (CAV2)-based FMD vaccines, Cav-P1/3C R° and Cav-VP1 R°, respectively expressing the structural P1 precursor protein along with the non-structural 3C protein or expressing the structural VP1 protein of the FMDV strain O/FRA/1/2001, were evaluated as novel vaccines against FMD. Read More

View Article
April 2018
6 Reads

HPV Infection and Cancer.

Authors:
Jill Jin

JAMA 2018 03;319(10):1058

View Article

Primary Sjögren's Syndrome.

N Engl J Med 2018 03;378(10):931-939

From the Department of Rheumatology, Université Paris Sud, INSERM Unité 1184, Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris Sud, Le Kremlin Bicêtre, France (X.M.); and the Rosalind Russell-Ephraim P. Engleman Rheumatology Research Center, Departments of Medicine and Orofacial Sciences, University of California at San Francisco, San Francisco (L.A.C.).

View Article
March 2018
2 Reads

Activation of Stimulator of Interferon Genes (STING) and Sjögren Syndrome.

J Dent Res 2018 Mar 1:22034518760855. Epub 2018 Mar 1.

1 Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.

Sjögren syndrome (SS), a chronic autoimmune disorder causing dry mouth, adversely affects the overall oral health in patients. Activation of innate immune responses and excessive production of type I interferons (IFNs) play a critical role in the pathogenesis of this disorder. Recognition of nucleic acids by cytosolic nucleic acid sensors is a major trigger for the induction of type I IFNs. Read More

View Article
March 2018
1 Read

A pathological study of the tongues of rabid dogs in the Philippines.

Arch Virol 2018 Jun 2;163(6):1615-1621. Epub 2018 Mar 2.

Department of Veterinary Pathology, School of Veterinary Medicine, Kitasato University, 23-35-1 Higashi, Towada, Aomori, 034-8628, Japan.

During rabies virus infections, the minor salivary glands are one of the important organs for virus replication and excretion into the oral cavity. However, details of pathological findings and viral antigen distribution in the minor salivary glands remain poorly understood. In this study, we conducted pathological tests on the tongues of 71 rabid dogs in the Philippines; the minor salivary glands (von Ebner's glands, lingual glands), circumvallate papilla, autonomic ganglia, and skeletal muscles were evaluated. Read More

View Article
June 2018
2 Reads

Effects of relative humidity on childhood hand, foot, and mouth disease reinfection in Hefei, China.

Sci Total Environ 2018 Jul 7;630:820-826. Epub 2018 Mar 7.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Shushan District, Hefei, Anhui 230032, PR China. Electronic address:

Background: In recent years, hand, foot, and mouth disease (HFMD) has become a major public health issue in China, and its reinfection rate has been high. Numerous studies have examined the effects of meteorological factors involved in HFMD infection. However, no study has investigated the effects on HFMD reinfection. Read More

View Article

[Epidemiology of oral HPV infection in young healthy individuals].

Rev Chilena Infectol 2017 Dec;34(6):557-562

Centro de Investigaciones Regionales "Dr. Hideyo Noguchi" Campus de Ciencias de la Salud Unidad de Ciencias Biomédicas Inalámbrica, Universidad Autónoma de Yucatán, Mérida, Yucatán, México.

Background: HPV infection is the most common sexually transmitted viral infection, and is associated with several neoplasms.

Aim: To describe the epidemiology, natural history and risk factors associated with oral HPV infection in asymptomatic young adults.

Methods: A prospective and longitudinal study was conducted, including subjects without oral pathology, who were sampled from the oral mucosa. Read More

View Article
December 2017

Systemic antibodies administered by passive immunization prevent generalization of the infection by foot-and-mouth disease virus in cattle after oronasal challenge.

Virology 2018 05 15;518:143-151. Epub 2018 Mar 15.

Instituto de Virología, CICVyA, INTA, N Repetto y De Los Reseros s/n, Hurlingham (1686), Buenos Aires, Argentina; CONICET, Godoy Cruz 2290 (C1425FQB), Buenos Aires, Argentina. Electronic address:

The role of passively transferred sera in the protection against aerogenous foot-and-mouth disease (FMD) virus infection in cattle was evaluated using vaccine-induced immune serum preparations obtained at 7 and 26 days post-vaccination (dpv). We showed that circulating antibodies were sufficient to prevent disease generalization after oronasal infection in animals passively transferred with 26-dpv serum but not with the 7-dpv serum. Conversely, conventional FMD vaccination provided clinical protection at 7 dpv, promoting fast and robust antibody responses upon challenge and even though antibody titers were similar to those found in animals passively immunized with 7-dpv serum. Read More

View Article
May 2018
1 Read

Comprehensive virome analysis reveals the complexity and diversity of the viral spectrum in pediatric patients diagnosed with severe and mild hand-foot-and-mouth disease.

Virology 2018 05 19;518:116-125. Epub 2018 Feb 19.

Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China. Electronic address:

The management of hand-foot-and-mouth disease(HFMD) epidemic is difficult due to the frequent emergence of non-EV71 and non-CVA16 enteroviruses and some cases testing negative for HFMD-associated causative agents. To clarify the virus spectrum of mild and severe HFMD, a comprehensive virome analysis of 238 samples was performed using next-generation sequencing (NGS). The data revealed total thirteen mammalian- and plant- virus families and diverse viral populations including enteroviruses, common respiratory viruses, diarrhea-related viruses, plant viruses and anelloviruses. Read More

View Article
May 2018
7 Reads

Infantile bullous pemphigoid with "string of pearls sign".

Dermatol Online J 2017 Jul 15;23(7). Epub 2017 Jul 15.

Department of Dermatology, Centro Hospitalar do Porto, Portugal.

Bullous pemphigoid (BP) is an immune mediated bullous disease that is manifested by urticarial plaques with superimposed subepidermal blisters and significant pruritus. It is generally found in the elderly, but is rare in the pediatric population. A 5-month-old girl previously diagnosed with hand-foot-mouth disease was examined in our dermatology department owing to vesicles and bullae, initially located to the hands and feet, which progressed with new lesions. Read More

View Article
July 2017
3 Reads