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    13875 results match your criteria Viral Infections of the Mouth

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    A colorimetric and electrochemical immunosensor for point-of-care detection of enterovirus 71.
    Biosens Bioelectron 2017 Jul 14;99:186-192. Epub 2017 Jul 14.
    Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, PR China.
    Point-of-care detection of human enterovirus 71 (EV71), the major pathogen that causes hand, foot, and mouth disease (HFMD) among children, is urgently needed for early diagnosis and control of related epidemics. A colorimetric and electrochemical immunosensor for point-of-care detection of EV71 has been developed based on dual-labeled magnetic nanobeads amplification. The dual-labeled magnetic nanobeads (DL-MBs) are fabricated by simultaneous immobilization of EV71 monoclonal antibody (mAb) and horseradish peroxidase (HRP) on magnetic nanobeads. Read More

    Human enteroviruses associated with and without diarrhea in Thailand between 2010 and 2016.
    PLoS One 2017 27;12(7):e0182078. Epub 2017 Jul 27.
    Center of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
    Non-bacterial acute gastroenteritis (AGE) associated with virus infection affects individuals living in developing countries, especially children. To investigate whether shedding of certain human enterovirus (EV) is more frequently detected in the stool of individuals with AGE of unknown etiology than individuals without AGE symptoms, we tested fecal samples collected from 2,692 individuals with diarrhea between January 2010 and December 2016. Samples were tested for rotavirus, norovirus, and EV by reverse-transcription polymerase chain reaction (RT-PCR) and adenovirus by PCR. Read More

    Post-medication Stevens-Johnson syndrome in a girl hospitalized for a norovirus and rotavirus infection.
    Rom J Morphol Embryol 2017 ;58(2):681-683
    Department of Pediatrics, "Vasile Goldis" Western University of Arad, Romania;
    Stevens-Johnson syndrome (SJS) is a cutaneous mucosal disorder characterized by extended necrosis and detachment of the epidermis affecting <10% of the body surface, caused by drugs or infections. The authors report a case of a girl with Depakine resistant epilepsy, who develops a SJS in the third week of introducing lamotrigine. The girl also presents an acute diarrheal disease with double viral etiology - rotavirus and norovirus. Read More

    Perspectives about Pandemic Influenza and Its Prophylactic Measures among Final Year Pharmacy Students in Karachi, Pakistan.
    J Pharm Bioallied Sci 2017 Apr-Jun;9(2):144-151
    Department of Pharmacy Practice, International Islamic University Malaysia, Pahang, Malaysia.
    Aims: In flu pandemics, pharmacy students' knowledge, attitudes, and practices are critical to save patients life. The objective of study was to determine the knowledge of and attitude toward the pandemic influenza among the pharmacy students of Karachi, Pakistan.

    Settings And Designs: The cross-sectional study was conducted from September to December 2014 by adopting a prevalidated questionnaire distributed to senior pharmacy students (final year) in seven private and public sector universities of Karachi. Read More

    Development of real-time and lateral flow dipstick recombinase polymerase amplification assays for rapid detection of goatpox virus and sheeppox virus.
    Virol J 2017 Jul 17;14(1):131. Epub 2017 Jul 17.
    State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Xujiaping 1, Lanzhou, Gansu, 730046, China.
    Background: Goatpox virus (GTPV) and sheeppox virus (SPPV), which belong to the Capripoxvirus (CaPV), are economically important pathogens of small ruminants. Therefore, a sensitive, specific and rapid diagnostic assay for detection of GTPV and SPPV is necessary to accurately and promptly control these diseases.

    Methods: Recombinase polymerase amplification (RPA) assays combined with a real-time fluorescent detection (real-time RPA assay) and lateral flow dipstick (RPA LFD assay) were developed targeting the CaPV G-protein-coupled chemokine receptor (GPCR) gene, respectively. Read More

    Emergence and whole-genome sequence of Senecavirus A in Colombia.
    Transbound Emerg Dis 2017 Jul 16. Epub 2017 Jul 16.
    Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, MN, USA.
    In 2015 and 2016, Senecavirus A (SVA) emerged as an infectious disease in Brazil, China and the United States (US). In a Colombian commercial swine farm, vesicles on the snout and coronary bands were reported and tested negative for foot-and-mouth disease virus (FMDv), but positive for SVA. The whole-genome phylogenetic analysis indicates the Colombian strain clusters with the strains from the United States, not with the recent SVA strains from Brazil. Read More

    Identification of a conformational neutralizing epitope on the VP1 protein of type A foot-and-mouth disease virus.
    Res Vet Sci 2017 Jul 8;115:374-381. Epub 2017 Jul 8.
    Division of Livestock Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, NO. 678 Haping Road Xiangfang District, Harbin 150069, PR China.
    Foot-and-mouth disease (FMD) caused by foot-and-mouth disease virus (FMDV), is a highly contagious infectious disease that affects domestic and wild cloven-hoofed animals worldwide. In recent years, outbreaks of serotype A FMD have occurred in many countries. High-affinity neutralizing antibodies against a conserved epitope could provide protective immunity against diverse subtypes of FMDV serotype A and protect against future pandemics. Read More

    dsRNA Binding Domain of PKR Is Proteolytically Released by Enterovirus A71 to Facilitate Viral Replication.
    Front Cell Infect Microbiol 2017 28;7:284. Epub 2017 Jun 28.
    Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung UniversityTaoyuan, Taiwan.
    Enterovirus 71 (EV-A71) causes hand, foot and mouth disease in young children and infants, but can also cause severe neurological complications or even death. The double-stranded RNA (dsRNA)-dependent protein kinase R (PKR), an interferon-induced antiviral protein, phosphorylates the regulatory α-subunit of the eukaryotic translation initiation factor 2 in response to viral infection, thereby blocking the translation of cellular and viral mRNA and promoting apoptosis. The cleavage of PKR after infection with poliovirus, a prototype enterovirus, has been reported by others, but the underlying mechanism of this cleavage and its role in viral replication remain unclear. Read More

    Modulation of Host miRNAs Transcriptome in Lung and Spleen of Peste des Petits Ruminants Virus Infected Sheep and Goats.
    Front Microbiol 2017 26;8:1146. Epub 2017 Jun 26.
    Computational Biology and Genomics Facility Lab, Division of Veterinary Biotechnology, Indian Council of Agricultural Research-Indian Veterinary Research Institute, BareillyIndia.
    Peste des petits ruminants (PPR) is one of the highly contagious viral disease, characterized by fever, sore mouth, conjunctivitis, gastroenteritis, and pneumonia, primarily affecting sheep and goats. Reports suggested variable host response in goats and sheep and this host response vis-a-vis the expression of microRNAs (miRNAs) has not been investigated. Here, miRNAs were sequenced and proteomics data were generated to identify the role of differentially expressed miRNA (DEmiRNA) in PPR virus (PPRV) infected lung and spleen tissues of sheep and goats. Read More

    Experimental co-infection of infectious bronchitis and low pathogenic avian influenza H9N2 viruses in commercial broiler chickens.
    Res Vet Sci 2017 Jun 30;115:356-362. Epub 2017 Jun 30.
    Department of Poultry Diseases, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef 62511, Egypt.
    In this study, commercial broilers were experimentally infected with single (classical IBV, variant IBV or AIV-H9N2) or mixed AIV-H9N2 with classical, variant or vaccine strains of IBV. Birds were monitored for clinical and pathological outcomes and virus shedding for 10days post infection (DPI). Clinical signs were limited to the respiratory tract in all challenged groups and varied from mild to moderate mouth breathing to severe respiratory signs with snorting sound and extended head. Read More

    Diagnosis and treatment of herpes simplex 1 virus infection in pregnancy.
    Obstet Med 2017 Jun 1;10(2):58-60. Epub 2017 Feb 1.
    Department of Obstetrics and Gynaecology, Royal Gwent Hospital, Newport, UK.
    A nulliparous woman presented at 21 weeks' gestation with a 72-h history of a rash on her left arm. Initially isolated to the forearm, it had quickly spread, becoming multiple itchy fluid-filled blisters. Blood tests showed mild neutrophilia and raised CRP. Read More

    Foot-and-mouth disease virus induces lysosomal degradation of host protein kinase PKR by 3C proteinase to facilitate virus replication.
    Virology 2017 Sep 26;509:222-231. Epub 2017 Jun 26.
    State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Diseases Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, PR China. Electronic address:
    The interferon-induced double-strand RNA activated protein kinase (PKR) plays important roles in host defense against viral infection. Here we demonstrate the significant antiviral role of PKR against foot-and-mouth disease virus (FMDV) and report that FMDV infection inhibits PKR expression and activation in porcine kidney (PK-15) cells. The viral nonstructural protein 3C proteinase (3C(pro)) is identified to be responsible for this inhibition. Read More

    Molecular Mechanisms of Foot-and-Mouth Disease Virus Targeting the Host Antiviral Response.
    Front Cell Infect Microbiol 2017 13;7:252. Epub 2017 Jun 13.
    Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas-UAM)Madrid, Spain.
    Foot-and-mouth disease virus (FMDV) is the causative agent of an acute vesicular disease affecting pigs, cattle and other domestic, and wild animals worldwide. The aim of the host interferon (IFN) response is to limit viral replication and spread. Detection of the viral genome and products by specialized cellular sensors initiates a signaling cascade that leads to a rapid antiviral response involving the secretion of type I- and type III-IFNs and other antiviral cytokines with antiproliferative and immunomodulatory functions. Read More

    Phylogeography of coxsackievirus A16 reveals global transmission pathways and recent emergence and spread of a recombinant genogroup.
    J Virol 2017 Jun 28. Epub 2017 Jun 28.
    Université Clermont Auvergne, CNRS, LMGE, F-63000 Clermont-Ferrand, France
    Coxsackievirus A16 (CV-A16; Picornaviridae) is an enterovirus (EV) type associated with hand-foot-and-mouth disease (HFMD) in children. To investigate the spatial spread of CV-A16, we used viral sequence data sampled during a prospective sentinel surveillance of HFMD in France (2010--2014) and phylogenetic reconstruction. A dataset of 168 VP1 sequences was assembled with 416 publicly available sequences of various geographic origins. Read More

    [Clinical stages and outcomes of severe cases on hand, foot and mouth disease].
    Zhonghua Liu Xing Bing Xue Za Zhi 2017 May;38(5):651-655
    Institute of Infectious Disease, Sichuan Provincial Center for Disease Control and Prevention, Chengdu 610041, China.
    Objective: To understand the characteristics and relation of clinical stage and outcome of severe cases on hand, foot and mouth disease (HFMD) and to establish the evaluation method for understanding severity of this disease. Methods: According to factors as geographical location, economic and epidemic levels, five provinces (Henan, Shandong, Yunnan, Zhejiang and Sichuan provinces) were selected. Reported severe cases of HFMD from the National Notifiable Diseases Reporting System were selected randomly in the five provinces. Read More

    Differential replication of Foot-and-mouth disease viruses in mice determine lethality.
    Virology 2017 Sep 23;509:195-204. Epub 2017 Jun 23.
    Instituto de Biotecnología, Instituto Nacional de Tecnología Agropecuaria (INTA), De los Reseros y N. Repetto s/n, (1686) Hurlingham, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina. Electronic address:
    Adult C57BL/6J mice have been used to study Foot-and-mouth disease virus (FMDV) biology. In this work, two variants of an FMDV A/Arg/01 strain exhibiting differential pathogenicity in adult mice were identified and characterized: a non-lethal virus (A01NL) caused mild signs of disease, whereas a lethal virus (A01L) caused death within 24-48h independently of the dose used. Both viruses caused a systemic infection with pathological changes in the exocrine pancreas. Read More

    T135I substitution in the nonstructural protein 2C enhances foot-and-mouth disease virus replication.
    Virus Genes 2017 Jun 20. Epub 2017 Jun 20.
    Division of Livestock Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No. 678 Haping Road, Xiangfang District, Harbin, 150069, People's Republic of China.
    The foot-and-mouth disease virus (FMDV) nonstructural protein 3A plays an important role in viral replication, virulence, and host range. It has been shown that deletions of 10 or 19-20 amino acids in the C-terminal half of 3A attenuate serotype O and C FMDVs, which replicate poorly in bovine cells but normally in porcine-derived cells, and the C-terminal half of 3A is not essential for serotype Asia1 FMDV replication in BHK-21 cells. In this study, we constructed a 3A deletion FMDV mutant based on a serotype O FMDV, the wild-type virus O/YS/CHA/05, with a 60-amino acid deletion in the 3A protein sequence, between residues 84 and 143. Read More

    Immunogenicity of T7 bacteriophage nanoparticles displaying G-H loop of foot-and-mouth disease virus (FMDV).
    Vet Microbiol 2017 Jun 4;205:46-52. Epub 2017 May 4.
    National Research Center of Engineering and Technology for Veterinary Biologicals, Jiangsu Academy of Agricultural Science, Nanjing 210014, Jiangsu Province, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, Jiangsu Province, China. Electronic address:
    Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals that causes severe economic losses worldwide. The G-H loop of the FMDV VP1 structural protein is the major neutralizing antigenic site. However, a fully protective G-H loop peptide vaccine requires the addition of promiscuous Th sites from a source outside VP1. Read More

    Management of viral oral ulcers in children using Chinese herbal medicine: A report of two cases.
    Complement Ther Med 2017 Jun 12;32:61-65. Epub 2017 Apr 12.
    Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address:
    Objective: Viral oral ulcers are common presentations in pediatric clinics. Although self-limiting, painful ulcerative lesions and inflamed mucosa can decrease oral intake and lead to dehydration. Despite the widespread use of Chinese herbal medicine (CHM) for pediatric upper respiratory disease in Taiwan, there is little evidence for its effectiveness as an antipyretic or in aiding ulcer healing for children with viral oral ulcers. Read More

    Inter-laboratory validation of foot-and-mouth disease diagnostic capability in Germany.
    Vet Microbiol 2017 May 2;203:62-67. Epub 2017 Mar 2.
    Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Südufer 10, 17493 Greifswald-Insel Riems, Germany.
    Germany has been free from foot-and-mouth disease virus (FMDV) without vaccination since 1992, but diagnostic capability at regional laboratories is maintained for FMDV exclusion in suspect cases and as surge capacity for outbreak preparedness. A proficiency test was initiated in 2015 to evaluate the diagnostic performance of 20 regional veterinary laboratories. A panel of two identical samples of FMDV genome for real-time reverse transcription polymerase chain reaction (RT-PCR), four lyophilized bovine sera for antibody detection and eight samples of inactivated vaccine antigen for analysis with a lateral-flow device (LFD) were tested with the systems routinely used at the participating institutions. Read More

    Breast Milk Is a Potential Vehicle for Human Papillomavirus Transmission to Oral Mucosa of the Spouse.
    Pediatr Infect Dis J 2017 Jul;36(7):627-630
    From the *Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland; †Department of Oral Pathology and Radiology, University of Turku, Turku, Finland; ‡Department of Obstetrics and Gynecology, Turku University Hospital, University of Turku, Turku, Finland; §Department of Clinical Research, Biohit Oyj, Helsinki, Finland; and ¶Department of Pathology, Turku University Hospital, Turku, Finland.
    Background: Human papillomavirus (HPV) DNA has been detected in breast milk, but its origin has remained obscure. The aim of the study was to analyze the prevalence and persistence of HPV in breast milk in the Finnish Family HPV cohort study. The association of breast milk HPV positivity with the family members' oral HPV status was evaluated. Read More

    Chemiluminescence Immunoassay for the Detection of Antibodies against the 2C and 3ABC Nonstructural Proteins Induced by Infecting Pigs with Foot-and-Mouth Disease Virus.
    Clin Vaccine Immunol 2017 Aug 4;24(8). Epub 2017 Aug 4.
    State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Diseases Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, People's Republic of China
    The potential diagnostic value of chemiluminescence immunoassays (CLIAs) has been accepted in recent years, although their use for foot-and-mouth disease (FMD) diagnostics has not been reported. Full-length 3ABC and 2C proteins were expressed in bacteria and purified by affinity chromatography to develop a rapid and accurate approach to distinguish pigs infected with foot-and-mouth disease virus (FMDV) from vaccinated pigs. The recombinant proteins were then used as antigens to develop two CLIAs for the detection of antibodies against nonstructural viral proteins. Read More

    Oral Candida spp carriage and periodontal diseases in HIV-infected patients in Ribeirão Preto, Brazil.
    Rev Inst Med Trop Sao Paulo 2017 Jun 1;59:e29. Epub 2017 Jun 1.
    Universidade de São Paulo, Faculdade de Odontologia de Ribeirão Preto, Departamento de Morfologia, Fisiologia e Patologia Básica, Ribeirão Preto, São Paulo, Brazil.
    The majority of HIV-infected patients develop Candida spp-associated clinical oral lesions. Studies have shown that asymptomatic oral colonization of Candida spp may lead to oral lesions or become a source of disseminated infections. The aim of this study was to verify the effects of periodontal conditions on Candida spp prevalence and Candida spp carriage in the oral cavity of HIV-infected patients compared to non-infected patients. Read More

    Mosquito co-infection with Zika and chikungunya virus allows simultaneous transmission without affecting vector competence of Aedes aegypti.
    PLoS Negl Trop Dis 2017 Jun 1;11(6):e0005654. Epub 2017 Jun 1.
    Laboratory of Virology, Wageningen University & Research, Wageningen, The Netherlands.
    Background: Zika virus (ZIKV) and chikungunya virus (CHIKV) are highly pathogenic arthropod-borne viruses that are currently a serious health burden in the Americas, and elsewhere in the world. ZIKV and CHIKV co-circulate in the same geographical regions and are mainly transmitted by Aedes aegypti mosquitoes. There is a growing number of case reports of ZIKV and CHIKV co-infections in humans, but it is uncertain whether co-infection occurs via single or multiple mosquito bites. Read More

    A Synonymous Mutation at Bovine Alpha Vitronectin Domain of Integrin Host Receptor (ITGAV) Gene Effect the Susceptibility of Foot-and-Mouth Disease in Crossbred Cattle.
    Adv Exp Med Biol 2017 Jun 1. Epub 2017 Jun 1.
    Molecular Genetics Laboratory, ICAR-Central Institute for Research on Cattle, Meerut, 250 001, Uttar Pradesh, India.
    Integrins are one of the major biologically active proteins responsible for Foot-and-mouth disease virus (FMDV)- host interaction. Out of various heterodimeric integrins discovered, αVβ6 heterodimer serves as the chief receptor for FMDV host tropism. Earlier studies reported that, SNPs at beta 6 subunit (ITGB6) were associated with the occurrence of the diseases in cattle. Read More

    Rapid Engineering of Foot-and-Mouth Disease Vaccine and Challenge Viruses.
    J Virol 2017 Aug 27;91(16). Epub 2017 Jul 27.
    Animal and Plant Quarantine Agency, Gimcheon City, Gyeongsangbuk-do, Republic of Korea
    There are seven antigenically distinct serotypes of foot-and-mouth disease virus (FMDV), each of which has intratypic variants. In the present study, we have developed methods to efficiently generate promising vaccines against seven serotypes or subtypes. The capsid-encoding gene (P1) of the vaccine strain O1/Manisa/Turkey/69 was replaced with the amplified or synthetic genes from the O, A, Asia1, C, SAT1, SAT2, and SAT3 serotypes. Read More

    Emergence of novel Seneca Valley virus strains in China, 2017.
    Transbound Emerg Dis 2017 Aug 23;64(4):1024-1029. Epub 2017 May 23.
    State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Diseases Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
    Since early 2017, several outbreaks of Seneca Valley virus (SVV) infection have re-emerged in China. We report the identification of novel SVV KS15-01-like strains showing a notable distinction with previous Chinese SVV strains. The determined SVV strains are currently causing new outbreaks in two provinces in China where no SVV infection has been reported previously, implying the increased epidemic regions and potential threat to local pig breeds of SVV in China. Read More

    wMel limits zika and chikungunya virus infection in a Singapore Wolbachia-introgressed Ae. aegypti strain, wMel-Sg.
    PLoS Negl Trop Dis 2017 May 19;11(5):e0005496. Epub 2017 May 19.
    School of Biological Sciences, Monash University, Melbourne, Australia.
    Background: Zika (ZIKV) and Chikungunya (CHIKV) viruses are emerging Aedes-borne viruses that are spreading outside their known geographic range and causing wide-scale epidemics. It has been reported that these viruses can be transmitted efficiently by Ae. aegypti. Read More

    Dynamic Interaction of Enterovirus 71 and Dendritic Cells in Infected Neonatal Rhesus Macaques.
    Front Cell Infect Microbiol 2017 10;7:171. Epub 2017 May 10.
    Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical CollegeKunming, China.
    Enterovirus 71 (EV71) is one of the main pathogens responsible for hand, foot, and mouth disease (HFMD). Infection with EV71 can lead to severe clinical disease via extensive infections of either the respiratory or alimentary tracts in children. Based on the previous pathological study of EV71 infections in neonatal rhesus macaques, our work using this animal model and an EV71 chimera that expresses enhanced green fluorescent protein (EGFP-EV71) primarily explored where EV71 localizes and proliferates, and the subsequent initiation of the pathological process. Read More

    [Update on congenital and neonatal herpes infections: infection due to cytomegalovirus and herpes simplex].
    Rev Neurol 2017 May;64(s03):S29-S33
    Hospital Universitario La Paz, Madrid, Espana.
    Newborn infants are a population which is especially susceptible to viral infections that frequently affect the central nervous system. Herpes infections can be transmitted to the foetus and to the newborn infant, and give rise to severe clinical conditions with long-term sensory and cognitive deficits. Two thirds of newborn infants with encephalitis due to herpes simplex virus and half of the children with symptomatic congenital infection by cytomegalovirus develop sequelae, which results in high community health costs in the long term. Read More

    Attenuation of Foot-and-Mouth Disease Virus by Engineered Viral Polymerase Fidelity.
    J Virol 2017 Aug 12;91(15). Epub 2017 Jul 12.
    Plum Island Animal Disease Center, North Atlantic Area, Agricultural Research Service, U.S. Department of Agriculture, Greenport, New York, USA
    Foot-and-mouth disease virus (FMDV) RNA-dependent RNA polymerase (RdRp) (3D(pol)) catalyzes viral RNA synthesis. Its characteristic low fidelity and absence of proofreading activity allow FMDV to rapidly mutate and adapt to dynamic environments. In this study, we used the structure of FMDV 3D(pol) in combination with previously reported results from similar picornaviral polymerases to design point mutations that would alter replication fidelity. Read More

    Ebola exposure, illness experience, and Ebola antibody prevalence in international responders to the West African Ebola epidemic 2014-2016: A cross-sectional study.
    PLoS Med 2017 May 16;14(5):e1002300. Epub 2017 May 16.
    Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, United Kingdom.
    Background: Healthcare and other front-line workers are at particular risk of infection with Ebola virus (EBOV). Despite the large-scale deployment of international responders, few cases of Ebola virus disease have been diagnosed in this group. Since asymptomatic or pauci-symptomatic infection has been described, it is plausible that infections have occurred in healthcare workers but have escaped being diagnosed. Read More

    Increased expression of CD38 and HLADR in HIV-infected patients with oral lesion.
    J Med Virol 2017 Oct 15;89(10):1782-1787. Epub 2017 Jun 15.
    School of Medicine, Federal University of Bahia, Salvador, Bahia, Brazil.
    Persistent immune actiation is associated with innadequate immune recovery in HIV-patients. This study assessed the relationship between frequency of expression of cell activation markers (CD38 and HLADR) and presence of oral lesions in HIV-1 infected patients. Fifty-seven HIV-infected persons, undergoing antiretroviral treatment, were divided into three groups, according to the number of CD4(+) T cells and CD4(+) /CD8(+) ratio: adequate, partial, and inadequate immune restauration. Read More

    Transcriptomic analysis of porcine PBMCs in response to FMDV infection.
    Acta Trop 2017 Sep 8;173:69-75. Epub 2017 May 8.
    State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province 730046, People's Republic of China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu Province 225009, People's Republic of China. Electronic address:
    Foot-and-mouth disease (FMD) is a significant zoonotic infectious disease. It has an important economic impact throughout the world. As well, it is a considerable threat to food security. Read More

    A Naturally Occurring Recombinant Enterovirus Expresses a Torovirus Deubiquitinase.
    J Virol 2017 Jul 26;91(14). Epub 2017 Jun 26.
    Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA
    Enteroviruses (EVs) are implicated in a wide range of diseases in humans and animals. In this study, a novel enterovirus (enterovirus species G [EVG]) (EVG 08/NC_USA/2015) was isolated from a diagnostic sample from a neonatal pig diarrhea case and identified by using metagenomics and complete genome sequencing. The viral genome shares 75. Read More

    Valine/isoleucine variants drive selective pressure in the VP1 sequence of EV-A71 enteroviruses.
    BMC Infect Dis 2017 May 8;17(1):333. Epub 2017 May 8.
    Cirad, UMR 17, Intertryp, TA-A17/G, Campus International de Baillarguet, 34398, Montpellier Cedex 5, France.
    Background: In 2011-2012, Northern Vietnam experienced its first large scale hand foot and mouth disease (HFMD) epidemic. In 2011, a major HFMD epidemic was also reported in South Vietnam with fatal cases. This 2011-2012 outbreak was the first one to occur in North Vietnam providing grounds to study the etiology, origin and dynamic of the disease. Read More

    [Observation on intestinal viral shedding time of hand, foot and mouth disease induced by coxsackievirus A6].
    Zhonghua Er Ke Za Zhi 2017 May;55(5):369-372
    Department of Infectious Diseases, Hangzhou Children's Hospital, Hangzhou 310014, China.
    Objective: To observe the intestinal viral shedding time in patients with hand, food and mouth disease (HFMD) induced by coxsackievirus A6 (CA6). Method: Throat swab specimens and stool specimens of HFMD children were collected from those admitted to Hangzhou Children's Hospital between May and October 2015, while fluorescence quantitative PCR was used to detect the viral load.Eeighteen cases of HFMD children were followed up, who were confirmed as CA6 infection via laboratory tests. Read More

    Neonatal Herpes Simplex Viral Infections and Acyclovir: An Update.
    J Pediatr Pharmacol Ther 2017 Mar-Apr;22(2):88-93
    Neonatal herpes simplex virus (HSV) infections have high morbidity and mortality rates. Optimization of treatment and prevention strategies are imperative to improve the care and outcomes of neonates infected with HSV. Management of HSV includes reducing neonatal transmission, treating acute infections, and limiting adverse neurodevelopmental outcomes and future cutaneous outbreaks after acute infections. Read More

    [Health related quality of life on severe hand, foot and mouth disease patients].
    Zhonghua Liu Xing Bing Xue Za Zhi 2017 Apr;38(4):462-466
    Division of Infectious Disease, Key Laboratory of Surveillance and Early Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
    Objective: To evaluate the health related quality of life (HRQoL) for severe hand, foot and mouth disease (HFMD) patients with different complications. Methods: A national telephone interview under the EQ-5D proxy2 questionnaire (EQ-SD and EQ-VAS), was conducted to obtain the HRQoL of lab-confirmed severe HFMD patients, aged between six months and five-year-olds from the national communicable disease surveillance system from January 1, 2012 to December 31, 2013. Results: A total of 685 severe HFMD cases were included in the study. Read More

    Tim-3-expressing macrophages are functionally suppressed and expanded in oral squamous cell carcinoma due to virus-induced Gal-9 expression.
    Tumour Biol 2017 May;39(5):1010428317701651
    Department of Stomatology, The Third Hospital of Hebei Medical University, Shijiazhuang, P.R. China.
    Oropharyngeal head and neck squamous cell carcinoma is a common malignant tumor in the oral cavity. High-risk human papillomavirus 16 infection is a major cause of oropharyngeal head and neck squamous cell carcinoma development. Strong antitumor immune responses, especially CD8(+) T cell responses, are thought to be essential to effective cancer treatment and are associated with better prognosis in oropharyngeal head and neck squamous cell carcinoma. Read More

    Laboratory validation of two real-time RT-PCR methods with 5'-tailed primers for an enhanced detection of foot-and-mouth disease virus.
    J Virol Methods 2017 Aug 27;246:90-94. Epub 2017 Apr 27.
    Service for Vesicular and Exotic Diseases, OD Viral Diseases, CODA-CERVA, Groeselenberg 99, 1180 Brussels, Belgium.
    The 3D and 5UTR real-time RT-PCR assays (RT-qPCR) from Callahan et al. (2002) and Reid et al. (2002) are commonly used reference methods for the detection of foot-and-mouth disease virus (FMDV). Read More

    [Oral lesions associated with human immunodeficiency virus disease in adult patients, a clinical perspective].
    Rev Chilena Infectol 2016 Oct;33(Suppl 1):27-35
    Departamento de Cirugía y Traumatología Máxilo-facial, Facultad de Odontología, Universidad de Chile, Santiago, Chile,
    Among the clinical manifestations which may occur in HIV/AIDS patients, oral lesions are relevant because there are easily accessible and usually the diagnosis is made through clinical features. Some oral manifestations are strongly related with HIV/AIDS patients indicating infection and progression to AIDS and also allow monitoring the success or failure of using antiretroviral therapy. The massive introduction of antiretroviral therapy has changed the morbidity and mortality, frequency, type of clinical manifestation and the timing of the classic opportunistic complications. Read More

    [Burkitt's lymphoma of the oral cavity: about a case].
    Pan Afr Med J 2017 3;26:63. Epub 2017 Feb 3.
    Service d'Odontologie Chirurgicale, Centre de Consultations et de Traitements Dentaire de Casablanca, Faculté de Médecine Dentaire de Casablanca, Maroc.
    Burkitt's lymphoma (LB) is a type of malignant non-Hodgkin's lymphoma originating from malignant B-cell transformation and proliferation. Positive confirmation is based on biopsy of the tumor mass or bone marrow aspiration revealing the presence of tumor cells. We here report the case of a young man, about twenty years old, addressed for post tooth extraction gingival swellings evolving for 1 month. Read More

    Interferon-free therapy with sofosbuvir plus ribavirin for successful treatment of genotype 2 hepatitis C virus with lichen planus: a case report.
    Clin J Gastroenterol 2017 Jun 26;10(3):270-273. Epub 2017 Apr 26.
    Division of Gastroenterology and Hepatology, Hokkaido University Hospital, Sapporo, Japan.
    Hepatitis C virus (HCV) infection remains the main cause of liver disease and can lead to chronic hepatitis, cirrhosis, and hepatocellular carcinoma. HCV may also develop extrahepatic manifestations in the skin, eyes, joints, kidneys, nervous system, and immune system. In fact, several studies reported that up to 70% of HCV patients experienced extrahepatic manifestations. Read More

    Alteration of serum high-mobility group protein 1 (HMGB1) levels in children with enterovirus 71-induced hand, foot, and mouth disease.
    Medicine (Baltimore) 2017 Apr;96(17):e6764
    Department of Childhood Infectious Diseases, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
    Hand, foot, and mouth disease (HFMD) is a common pediatric disease caused by enterovirus infection. It typically presents as a fever along with flat, discolored spots and bumps on the hands, feet, and mouth. Compared with other viruses, enterovirus 71 (EV71)-induced HFMD is more prone to cause severe complications in children, such as brainstem encephalitis, cardiopulmonary disorders, and even death. Read More

    Association of the OAS3 rs1859330 G/A genetic polymorphism with severity of enterovirus-71 infection in Chinese Han children.
    Arch Virol 2017 Aug 25;162(8):2305-2313. Epub 2017 Apr 25.
    Department of Pediatrics, The Affiliated Hospital of Qingdao University, No. 59, Haier Road, Qingdao, 266000, China.
    The 2'5'-oligoadenylate synthetase (OAS) is an interferon (IFN)-induced protein that plays an important role in the antiviral action of IFN, with OAS3 being one of the four OAS classes (OAS1, OAS2, OAS3, OASL). The effect of OAS on several infectious viral diseases has been reported; however, a study of the effect of OAS3 on enterovirus 71 (EV71) is lacking. The purpose of this study was to evaluate the association of the OAS3 rs1859330 G/A genetic polymorphism with susceptibility and severity of EV71 infection. Read More

    Evaluation of immune responses of stabilised SAT2 antigens of foot-and-mouth disease in cattle.
    Vaccine 2017 Apr 18. Epub 2017 Apr 18.
    Transboundary Animal Diseases Programme, Onderstepoort Veterinary Institute, Agricultural Research Council, Private Bag X05, Onderstepoort 0110, South Africa; Department of Microbiology and Plant Pathology, Faculty of Agricultural and Natural Sciences, University of Pretoria, Pretoria 0002, South Africa. Electronic address:
    Foot-and-mouth disease (FMD) vaccines with improved stability and less reliant on a cold-chain are needed to improve the longevity of immune responses elicited in animals. This is especially so for serotypes O and SAT2 which are unstable in mildly acidic pH conditions or at elevated temperatures leading to dissociation of the capsid (146S particle) and loss of immunogenicity. Previously, stabilised SAT2 viruses were generated by reverse genetic approaches and assessed in vitro and in vivo with a guinea pig trial. Read More

    Quality of life in survivors of oropharyngeal cancer: A systematic review and meta-analysis of 1366 patients.
    Eur J Cancer 2017 Jun 18;78:91-102. Epub 2017 Apr 18.
    Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, University Hospital Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark. Electronic address:
    Human papillomavirus (HPV)-associated oropharyngeal cancer (OPC) is rapidly increasing in incidence and has a favourable prognosis compared with HPV-negative disease. Current combined therapies include significant risks of morbidity for the growing group of survivors. This systematic review and meta-analysis investigates how treatment affects quality of life (QoL) in survivors of oropharyngeal cancer. Read More

    Dengue virus replicates and accumulates in Aedes aegypti salivary glands.
    Virology 2017 Jul 18;507:75-81. Epub 2017 Apr 18.
    Insect-Virus Interactions Group, Department of Genomes and Genetics, Institut Pasteur, 75015 Paris, France; Centre National de la Recherche Scientifique, Unité de Recherche Associée 3012, 75015 Paris, France. Electronic address:
    Dengue virus (DENV) is an RNA virus transmitted among humans by mosquito vectors, mainly Aedes aegypti. DENV transmission requires viral dissemination from the mosquito midgut to the salivary glands. During this process the virus undergoes several population bottlenecks, which are stochastic reductions in population size that restrict intra-host viral genetic diversity and limit the efficiency of natural selection. Read More

    Development of Isothermal Recombinase Polymerase Amplification Assay for Rapid Detection of Porcine Circovirus Type 2.
    Biomed Res Int 2017 23;2017:8403642. Epub 2017 Mar 23.
    State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 1, Lanzhou, Gansu 730046, China.
    Porcine circovirus virus type II (PCV2) is the etiology of postweaning multisystemic wasting syndrome (PMWS), porcine dermatitis, nephropathy syndrome (PDNS), and necrotizing pneumonia. Rapid diagnosis tool for detection of PCV2 plays an important role in the disease control and eradication program. Recombinase polymerase amplification (RPA) assays using a real-time fluorescent detection (PCV2 real-time RPA assay) and RPA combined with lateral flow dipstick (PCV2 RPA LFD assay) were developed targeting the PCV2 ORF2 gene. Read More

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